Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PBX1 Gene

protein-coding   GIFtS: 67
GCID: GC01P164524

Pre-B-Cell Leukemia Homeobox 1

(Previous name: pre-B-cell leukemia transcription factor 1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pre-B-Cell Leukemia Homeobox 11 2
Pre-B-Cell Leukemia Transcription Factor 11 2
Homeobox Protein PBX12 3
Homeobox Protein PRL2 3
PRL3

External Ids:    HGNC: 86321   Entrez Gene: 50872   Ensembl: ENSG000001856307   OMIM: 1763105   UniProtKB: P404243   

Export aliases for PBX1 gene to outside databases

Previous GC identifers: GC01P162163 GC01P160179 GC01P161224 GC01P161716 GC01P161260 GC01P162795 GC01P135774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PBX1 Gene:
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in
mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal
patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is
associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding
domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively
activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for PBX1 Gene: 
PBX1 (pre-B-cell leukemia homeobox 1) is a protein-coding gene. Diseases associated with PBX1 include acute lymphoblastic leukemia, and lymphoblastic leukemia, and among its related super-pathways are PKA activation in glucagon signalling. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PBX3.

UniProtKB/Swiss-Prot: PBX1_HUMAN, P40424
Function: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1.
Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis
and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex
in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds
to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A
element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a
transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is
required for spleen development through a mechanism that involves CDKN2B repression (By similarity)

Gene Wiki entry for PBX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PBX1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPBX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PBX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PBX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

PBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PBX1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P164524:  view genomic region     (about GC identifiers)

Start:
164,524,821 bp from pter      End:
164,868,533 bp from pter
Size:
343,713 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PBX1_HUMAN, P40424 (See protein sequence)
Recommended Name: Pre-B-cell leukemia transcription factor 1  
Size: 430 amino acids; 46626 Da
Subunit: Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms
heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with
PBXIP1 and TLX1. Isoform PBX1a interacts with MEIS2 isoform 4, SP1, SP3 and KLF4. Isoform PBX1b is part of a
PDX1:PBX1b:MEIS2b complex; PBX1b recruits Meis2B to the complex
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAA36764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for PBX1:
1B72 (3D)        1PUF (3D)    
Secondary accessions: B4DSC1 F5H4U9 Q5T488
Alternative splicing: 3 isoforms:  P40424-1   P40424-2   P40424-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PBX1: NX_P40424

Explore proteomics data for PBX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40424

  • PBX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PBX1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001191890.1  NP_001191892.1  NP_002576.1  

    ENSEMBL proteins: 
     ENSP00000473998   ENSP00000341455   ENSP00000405890   ENSP00000453188   ENSP00000356872  
     ENSP00000452804   ENSP00000452727   ENSP00000453163   ENSP00000453331   ENSP00000453262  
     ENSP00000439943   ENSP00000384856   ENSP00000440869  

    Human Recombinant Protein Products for PBX1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PBX1
    OriGene Protein Over-expression Lysate for PBX1
    OriGene MassSpec for PBX1 
    OriGene Custom Protein Services for PBX1
    GenScript Custom Purified and Recombinant Proteins Services for PBX1
    Novus Biologicals PBX1 Protein
    Novus Biologicals PBX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PBX1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA18973687

    PBX1 for ontologies           About GeneDecksing



    PBX1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PBX1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PBX1 
    OriGene Antibodies for PBX1
    OriGene Custom Antibody Services for PBX1
    GenScript Custom Superior Antibodies Services for PBX1
    Novus Biologicals PBX1 Antibodies
    Abcam antibodies for PBX1
    Cloud-Clone Corp. Antibodies for PBX1 
    ThermoFisher Antibodies for PBX1
    LSBio Antibodies in human, mouse, rat for PBX1 

    Assay Products for PBX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PBX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PBX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PBX1 
    Cloud-Clone Corp. CLIAs for PBX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TALE: Homeoboxes / TALE class

    4 InterPro protein domains:
     IPR005542 PBX
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P40424

    ProtoNet protein and cluster: P40424

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB005542 PBX domain


    UniProtKB/Swiss-Prot: PBX1_HUMAN, P40424
    Similarity: Belongs to the TALE/PBX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    PBX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PBX1_HUMAN, P40424
    Function: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1.
    Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis
    and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex
    in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds
    to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A
    element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a
    transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is
    required for spleen development through a mechanism that involves CDKN2B repression (By similarity)

         Genatlas biochemistry entry for PBX1:
    transcription factor,with an atypical homeo domain,homologous to mouse Meis1 (myeloid ecotropic viral integration
    site 1),expressed in most tissues,fetal and adult,binding DNA cooperatively with the heterodimer E2A/myogenic
    transcription factors,involved in pre-B cell leukemia and in acute myelogenous leukemia

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding IDA10052460
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10500199
    GO:0005515protein binding IPI10052460
    GO:0008134transcription factor binding IPI15684392
         
    PBX1 for ontologies           About GeneDecksing


    Phenotypes:
         15/22 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Pbx1) (see all 22):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    PBX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PBX1: Pbx1tm2.1Mlc Pbx1tm1.2Koss Pbx1tm1.1Febe Pbx1tm1Mlc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PBX1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PBX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PBX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PBX1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PBX1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate PBX1 (see all 109):
    hsa-miR-3130-5p hsa-miR-3607-3p hsa-miR-3152-3p hsa-miR-607 hsa-miR-300 hsa-miR-342-3p hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPBX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PBX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PBX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PBX1
    Sirion Biotech Customized adenovirus for overexpression of PBX1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PBX1 (see all 7)
    OriGene ORF clones in mouse, rat for PBX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PBX1 (NM_002585)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PBX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX1
    Sirion Biotech Customized lentivirus for stable overexpression of PBX1 
                         Customized lentivirus expression plasmids for stable overexpression of PBX1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PBX1
    Search LifeMap BioReagents cell lines for PBX1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PBX1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PKA activation in glucagon signalling
    Development Role of Activin A in cell differentiation and proliferation0.33
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    5Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PBX1
        Development Role of Activin A in cell differentiation and proliferation
    Transcription factors in neurogenesis


    1 Cell Signaling Technology (CST) Pathway for PBX1
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for PBX1
        Development Role of Activin A in cell differentiation and proliferation

    2 BioSystems Pathways for PBX1
        SIDS Susceptibility Pathways
    Glucocorticoid receptor regulatory network


    1         Kegg Pathway  (Kegg details for PBX1):
        Transcriptional misregulation in cancer


    PBX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PBX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for PBX1 (P404241, 2, 3 ENSP000004058904) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237344P404252, 3, ENSP000003971774MINT-50161 I2D: score=2 STRING: ENSP00000397177
    PBX2P404252, 3, ENSP000003641904MINT-50161 I2D: score=2 STRING: ENSP00000364190
    ENSG00000206315P404252, 3MINT-50161 I2D: score=2 
    ENSG00000224952P404252, 3MINT-50161 I2D: score=2 
    ENSG00000225987P404252, 3MINT-50161 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001655urogenital system development ----
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006694steroid biosynthetic process IEA--

    PBX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PBX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PBX1

    1 HMDB Compound for PBX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10/24 Novoseek inferred chemical compound relationships for PBX1 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hexarelin 85.1 29 11888836 (4), 11081154 (3), 9186817 (3), 11022186 (2) (see all 10)
    ghrp 75.2 2 2108187 (1), 9435437 (1)
    acth 58.6 32 11888836 (6), 9186817 (4), 11022186 (3), 10195374 (3) (see all 16)
    17-hydroxyprogesterone 50.7 5 11591421 (1), 14967374 (1), 17980364 (1), 10762292 (1) (see all 5)
    testosterone 43.7 19 16637071 (2), 7925123 (1), 15498182 (1), 7584521 (1) (see all 14)
    androstenedione 42 4 11591421 (1), 16650418 (1), 15516780 (1), 16460870 (1)
    glucose 35.4 28 8961128 (4), 9364253 (3), 15642799 (2), 17889857 (2) (see all 17)
    dehydroepiandrosterone sulfate 27.5 1 10594527 (1)
    metoclopramide 18.9 2 15642799 (1), 1815118 (1)
    tyrosine 16.7 4 8137766 (1), 10353695 (1), 9322918 (1), 11443173 (1)

    Search CenterWatch for drugs/clinical trials and news about PBX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PBX1 gene (3 alternative transcripts): 
    NM_001204961.1  NM_001204963.1  NM_002585.3  

    Unigene Cluster for PBX1:

    Pre-B-cell leukemia homeobox 1
    Hs.557097  [show with all ESTs]
    Unigene Representative Sequence: CR749446
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000467023 ENST00000485769 ENST00000340699 ENST00000420696(uc001gct.3 uc010pku.2 uc001gcs.3 uc010pkv.2)
    ENST00000498497 ENST00000559240 ENST00000367897 ENST00000605467 ENST00000559578
    ENST00000560469 ENST00000496120 ENST00000468104 ENST00000560641 ENST00000474046(uc001gcu.1)
    ENST00000482110 ENST00000558796 ENST00000558837 ENST00000559560
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PBX1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate PBX1 (see all 109):
    hsa-miR-3130-5p hsa-miR-3607-3p hsa-miR-3152-3p hsa-miR-607 hsa-miR-300 hsa-miR-342-3p hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPBX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PBX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PBX1
    Clone
    Products:
         
    OriGene clones in human, mouse for PBX1 (see all 7)
    OriGene ORF clones in mouse, rat for PBX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PBX1 (NM_002585)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PBX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX1
    Sirion Biotech Customized lentivirus for stable overexpression of PBX1 
                         Customized lentivirus expression plasmids for stable overexpression of PBX1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PBX1
    OriGene qSTAR qPCR primer pairs in human, mouse for PBX1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PBX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PBX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PBX1

    Additional mRNA sequence: 

    AK022520.1 AK022962.1 AK291415.1 AK299673.1 AK301540.1 AL049381.1 BC044624.1 BC101578.1 
    BC143435.1 BC143451.1 BT006705.1 BX538333.1 BX647313.1 CR749446.1 M31170.1 M86546.1 

    23 DOTS entries:

    DT.75124419  DT.95374674  DT.121457852  DT.209510  DT.100746154  DT.92027649  DT.95374673  DT.452633 
    DT.95150785  DT.100821728  DT.121457863  DT.100821729  DT.121643110  DT.100647181  DT.95374667  DT.121457803 
    DT.91918528  DT.92045099  DT.92059751  DT.92441618  DT.121060466  DT.121457891  DT.40254496 

    24/350 AceView cDNA sequences (see all 350):

    BE669859 BQ641658 CK904753 AL049381 CA396001 AA324597 AW135367 BM927093 
    AI638672 AW134773 BX955508 R17459 BU158509 AA083882 BM474583 AI417182 
    AA243108 AW166465 AI889898 BE503195 AA033676 T31436 BM702326 AI889907 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PBX1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                                                          -                                 
    SP2:                                                                          -     -                           
    SP3:        -                 -                                                                                 
    SP4:                                                                                                            
    SP5:                          -                                                                                 


    ECgene alternative splicing isoforms for PBX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PBX1 expression in normal human tissues (normalized intensities)      PBX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAAGAAG
    PBX1 Expression
    About this image


    PBX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Osteochondro Mesenchymal Cells Thoracic Rib
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Osteochondro Mesenchymal Cells Thoracic Rib
     
     Pancreas (Endocrine System)    fully expand to see all 6 entries
             Duct Cells Pancreatic Ducts
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Limb Bud Mesenchyme Cells Limb Bud

    See PBX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PBX1

    SOURCE GeneReport for Unigene cluster: Hs.557097

    UniProtKB/Swiss-Prot: PBX1_HUMAN, P40424
    Tissue specificity: Expressed in all tissues except in cells of the B and T lineage

        SABiosciences Expression via Pathway-Focused PCR Array including PBX1: 
              Notch Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PBX1
    OriGene qSTAR qPCR primer pairs in human, mouse for PBX1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PBX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PBX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PBX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PBX1 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pbx11 , 5 pre B cell leukemia homeobox 11, 5 95.66(n)1
    100(a)1
      1 (75.95 cM)5
    185141  NM_183355.21  NP_899198.11 
     1681535275 
    chicken
    (Gallus gallus)
    Aves PBX11 pre-B-cell leukemia homeobox 1 89.15(n)
    98.37(a)
      395505  NM_204746.1  NP_990077.1 
    lizard
    (Anolis carolinensis)
    Reptilia PBX16
    pre-B-cell leukemia homeobox 1
    95(a)
    1 ↔ 1
    GL343405.1(648257-873799)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.95632 Xenopus laevis pre-B-cell leukemia transcription factor more 85.14(n)    AF480430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pbx1a2 pre-B-cell leukemia transcription factor 1a 80.4(n)   58138  AJ245962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta exd1 , 3 brain development specific RNA
    polymerase II transcription more3
    extradenticle1
    80(a)3
    66.76(n)1
    76.32(a)1
      14A53
    325671  NM_078636.41  NP_523360.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-201 , 3 Protein CEH-201 64(a)
    (best of 2)3
    60.34(n)1
    64.48(a)1
      III(7051642-7053281)3
    35655451  NM_001027384.21  NP_001022555.11 


    ENSEMBL Gene Tree for PBX1 (if available)
    TreeFam Gene Tree for PBX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PBX1 gene
    PBX32  PBX42  PBX22  
    8 SIMAP similar genes for PBX1 using alignment to 11 protein entries:     PBX1_HUMAN (see all proteins):
    DKFZp686B09108    E2A/PBX1 fusion    PBX3    PBX2    PBX4    PKNOX1
    TGIF1    WUGSC

    PBX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5754 SNPs in PBX1 are shown (see all 5754)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669277171,2
    C--135775883(+) TTCTT-/CCCCCC 3 -- int10--------
    rs2016566041,2
    C--135775883(+) TTCTTC/TCCCCC 3 -- int10--------
    rs1447590081,2
    C--135806852(+) GCTTA-/AGAGAGT 3 -- int10--------
    rs1998518031,2
    C--135808983(+) ATAATA/TAATAG 3 -- int10--------
    rs746050911,2
    C--135808987(+) ATAAA-/GTAA  
            
    TAGCC
    3 -- int10--------
    rs1134846141,2
    C--135818035(+) GATTG-/A/AA  
            
    AAAAA
    3 -- int11CSA 2
    rs121239051,2
    A--135819274(+) tttttA/Ttagag 3 -- int1 trp30--------
    rs715834151,2
    C--135833607(+) ATCAC-/GGCG  
      
    /GGCGG
    GGGGG
    3 -- int11NA 2
    rs719291901,2
    C--135833607(+) AATCA-/CGGCGGGG 3 -- int10--------
    rs1388767151,2
    C--135845143(+) CTTGC-/CAATT 
            
    CTTTG
    3 -- int10--------

    HapMap Linkage Disequilibrium report for PBX1 (164524821 - 164774821 bp, first 250kb of PBX1)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PBX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678037CNV Deletion23128226
    esv2719017CNV Deletion23290073
    esv2719029CNV Deletion23290073
    esv268123CNV Insertion20981092
    nsv831792CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PBX1
    DNA2.0 Custom Variant and Variant Library Synthesis for PBX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176310    OMIM disorders: --

    UniProtKB/Swiss-Prot: PBX1_HUMAN, P40424
  • Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia
    (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. TCF3-PBX1 transforms cells by constitutively activating
    transcription of genes regulated by PBX1 or by other members of the PBX protein family

  • 20/50 diseases for PBX1 (see all 50):    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    combined pituitary hormone deficiency    pituitary hypoplasia
    t-cell leukemia    leukemia    familial prostate cancer    acromegaly
    hypopituitarism    prolactinoma    short stature    growth hormone deficiency
    multiple endocrine neoplasia    pituitary adenoma    pituitary tumors    insulinoma
    acute lymphocytic leukemia    cushing's syndrome    polycystic ovary syndrome    hyperparathyroidism

    1 disease from the University of Copenhagen DISEASES database for PBX1:
    Leukemia

    PBX1 for disorders           About GeneDecksing

    10/29 Novoseek inferred disease relationships for PBX1 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia pre-b-cell 94 12 8093327 (1), 9310317 (1), 1682799 (1), 15522959 (1) (see all 10)
    pituitary adenoma 60.2 5 11298082 (1), 16505278 (1), 15497657 (1), 11167934 (1) (see all 5)
    tsh deficiency 60.1 1 11549695 (1)
    lymphoblastic leukemia acute 57.3 9 12415113 (2), 1671560 (1), 1818313 (1), 8255105 (1) (see all 8)
    prolactinoma 55.7 4 11298082 (1), 18281148 (1), 1982864 (1), 7758228 (1)
    acromegaly 53.8 3 18281148 (1), 14713276 (1), 1982864 (1)
    leukemogenesis 50.6 4 19767769 (1), 9366523 (1), 12700034 (1)
    b-all 50 1 15801954 (1)
    leukemia 49.2 12 11369863 (1), 8327485 (1), 9010234 (1), 14764605 (1) (see all 12)
    pituitary tumors 48.4 1 9167954 (1)

    Genatlas disease: PBX1
    acute leukemia preB cell,with translocation t(1;19)(q23;p13.3) (see TCF3),upregulating the granulocyte
    colony-stimulating factor receptor (CSF3R)

    Genetic Association Database (GAD): PBX1
    Human Genome Epidemiology (HuGE) Navigator: PBX1 (9 documents)
    Tumor Gene Database (TGDB): PBX1

    Export disorders for PBX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PBX1 gene, integrated from 9 sources (see all 248):
    (articles sorted by number of sources associating them with PBX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians. (PubMed id 11267683)1, 2, 4 Thameem F.... Prochazka M. (2001)
    2. The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. (PubMed id 1671560)1, 2, 9 Hunger S.P....Cleary M.L. (1991)
    3. Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia. (PubMed id 8327485)1, 2, 9 van Dijk M.A.... Murre C. (1993)
    4. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. (PubMed id 10052460)1, 2, 9 Piper D.E.... Wolberger C. (1999)
    5. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PubMed id 1682799)1, 2, 9 Monica K.... Cleary M.L. (1991)
    6. Evaluation of sequence variants in the pre-B cell leukemia transcription factor 1 gene: a positional and functional candidate for type 2 diabetes and impaired insulin secretion. (PubMed id 16140554)1, 4, 9 Wang H....Elbein S.C. (2005)
    7. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. (PubMed id 7910944)1, 2, 9 Lu Q.... Kamps M.P. (1994)
    8. Cooperative transcriptional activation by Klf4, Meis2 , and Pbx1. (PubMed id 21746878)1, 2 Bjerke G.A....Wotton D. (2011)
    9. MEIS proteins as partners of the TLX1/HOX11 oncoprote in. (PubMed id 19559479)1, 2 Milech N....Watt P.M. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5087 HGNC: 8632 AceView: PBX1 Ensembl:ENSG00000185630 euGenes: HUgn5087
    ECgene: PBX1 Kegg: 5087 H-InvDB: PBX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PBX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PBX1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PBX1 gene:
    Search GeneIP for patents involving PBX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PBX1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PBX1   OriGene RNAi products in human, mouse, rat for PBX1  
     OriGene qPCR primer pairs and template standards for PBX1   OriGene Protein Over-expression Lysate for PBX1  
     OriGene MassSpec something-or-other for PBX1   OriGene clones in human, mouse for PBX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PBX1   OriGene Purified Protein for PBX1  
     OriGene ORF clones in mouse, rat for PBX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PBX1   OriGene Custom Protein Services for PBX1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PBX1
     QIAGEN SeqTarget long-range PCR primers for resequencing PBX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PBX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PBX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PBX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PBX1
     GenScript Custom Purified and Recombinant Proteins Services for PBX1 GenScript cDNA clones with any tag delivered in your preferred vector for PBX1
     GenScript Custom Assay Services for PBX1 GenScript Custom Superior Antibodies Services for PBX1
     GenScript Custom overexpressing Cell Line Services for PBX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PBX1 

     Regulatory tfbs in PBX1 promoter
     Search Chromatin IP Primers for PBX1
     RT2 qPCR Primer Assay in human, mouse, rat PBX1
     GNC Network for PBX1
     SABiosciences PCR Arrays including human, mouse, rat PBX1
     Search Tocris compounds for PBX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PBX1 antibodies
     PBX1 proteins
     PBX1 lysates
     Antibodies for PBX1
     See all of Abcam's Antibodies, Kits and Proteins for PBX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PBX1
     Antibodies for PBX1
     ELISAs for PBX1
     CLIAs for PBX1
     Search LifeMap BioReagents cell lines for PBX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX1
     SwitchGear 3'UTR luciferase reporter plasmids for PBX1
     SwitchGear Promoter luciferase reporter plasmids for PBX1
     ThermoFisher Antibodies for PBX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PBX1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PBX1
    Customized:
     lentivirus for stable overexpression of PBX1
     lentivirus expression plasmids for stable overexpression of PBX1
     adenovirus for overexpression of PBX1
     LSBio Antibodies in human, mouse, rat for PBX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PBX1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4