Aliases for PBRM1 Gene
External Ids for PBRM1 Gene
Previous GeneCards Identifiers for PBRM1 Gene
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
GeneCards Summary for PBRM1 Gene
PBRM1 (Polybromo 1) is a Protein Coding gene. Diseases associated with PBRM1 include clear cell papillary renal cell carcinoma and clear cell renal cell carcinoma. Among its related pathways are Chromatin organization and RNA Polymerase I Promoter Opening. GO annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot for PBRM1 Gene
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.