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Aliases for PBOV1 Gene

Aliases for PBOV1 Gene

  • Prostate And Breast Cancer Overexpressed 1 2 3
  • UROC28 3 4
  • UC28 3 4
  • Protein UROC28 4
  • DJ171N11.2 3

External Ids for PBOV1 Gene

Previous GeneCards Identifiers for PBOV1 Gene

  • GC06M138472
  • GC06M138517
  • GC06M138578

Summaries for PBOV1 Gene

Entrez Gene Summary for PBOV1 Gene

  • This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. [provided by RefSeq, Aug 2011]

GeneCards Summary for PBOV1 Gene

PBOV1 (Prostate And Breast Cancer Overexpressed 1) is a Protein Coding gene. Diseases associated with PBOV1 include breast cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBOV1 Gene

Genomics for PBOV1 Gene

Regulatory Elements for PBOV1 Gene

Genomic Location for PBOV1 Gene

Chromosome:
6
Start:
138,215,986 bp from pter
End:
138,218,491 bp from pter
Size:
2,506 bases
Orientation:
Minus strand

Genomic View for PBOV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PBOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBOV1 Gene

Proteins for PBOV1 Gene

  • Protein details for PBOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY1-PBOV1_HUMAN
    Recommended name:
    Prostate and breast cancer overexpressed gene 1 protein
    Protein Accession:
    Q9GZY1

    Protein attributes for PBOV1 Gene

    Size:
    135 amino acids
    Molecular mass:
    15722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PBOV1 Gene

Proteomics data for PBOV1 Gene at MOPED

Post-translational modifications for PBOV1 Gene

No Post-translational modifications

Other Protein References for PBOV1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBOV1 Gene

Domains & Families for PBOV1 Gene

Protein Domains for PBOV1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PBOV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PBOV1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PBOV1 Gene

Function for PBOV1 Gene

Phenotypes for PBOV1 Gene

genes like me logo Genes that share phenotypes with PBOV1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PBOV1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for PBOV1 Gene

Localization for PBOV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBOV1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBOV1 Gene COMPARTMENTS Subcellular localization image for PBOV1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PBOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PBOV1: view

Pathways & Interactions for PBOV1 Gene

SuperPathways for PBOV1 Gene

No Data Available

Interacting Proteins for PBOV1 Gene

Gene Ontology (GO) - Biological Process for PBOV1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PBOV1 Gene

Drugs & Compounds for PBOV1 Gene

No Compound Related Data Available

Transcripts for PBOV1 Gene

mRNA/cDNA for PBOV1 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PBOV1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PBOV1 Gene

No ASD Table

Relevant External Links for PBOV1 Gene

GeneLoc Exon Structure for
PBOV1
ECgene alternative splicing isoforms for
PBOV1

Expression for PBOV1 Gene

mRNA expression in normal human tissues for PBOV1 Gene

mRNA differential expression in normal tissues according to GTEx for PBOV1 Gene

This gene is overexpressed in Brain - Cerebellum (x10.4) and Brain - Cerebellar Hemisphere (x5.3).

SOURCE GeneReport for Unigene cluster for PBOV1 Gene Hs.302016

mRNA Expression by UniProt/SwissProt for PBOV1 Gene

Q9GZY1-PBOV1_HUMAN
Tissue specificity: Expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary, and peripheral blood leukocytes. Up-regulated expression in prostate, breast, and bladder cancer, but not in lung and colon cancer.
genes like me logo Genes that share expression patterns with PBOV1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PBOV1 Gene

Orthologs for PBOV1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PBOV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBOV1 35
  • 99.75 (n)
  • 100 (a)
Species with no ortholog for PBOV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PBOV1 Gene

ENSEMBL:
Gene Tree for PBOV1 (if available)
TreeFam:
Gene Tree for PBOV1 (if available)

Paralogs for PBOV1 Gene

No data available for Paralogs for PBOV1 Gene

Variants for PBOV1 Gene

Sequence variations from dbSNP and Humsavar for PBOV1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_059707 -

Variation tolerance for PBOV1 Gene

Residual Variation Intolerance Score: 77.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBOV1 Gene

HapMap Linkage Disequilibrium report
PBOV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PBOV1 Gene

Disorders for PBOV1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PBOV1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association
Search PBOV1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PBOV1

Genetic Association Database (GAD)
PBOV1
Human Genome Epidemiology (HuGE) Navigator
PBOV1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PBOV1
genes like me logo Genes that share disorders with PBOV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PBOV1 Gene

Publications for PBOV1 Gene

  1. Enhanced expression of the UROC28 gene in human breast cancer: relationship to ERBB2 gene expression. (PMID: 12553037) Kamagata C. … Watanabe N. (Anticancer Res. 2002) 2 23 67
  2. Cloning and characterization of UROC28, a novel gene overexpressed in prostate, breast, and bladder cancers. (PMID: 11156405) An G. … Veltri R.W. (Cancer Res. 2000) 2 67
  3. PBOV1 is a human de novo gene with tumor-specific expression that is associated with a positive clinical outcome of cancer. (PMID: 23418531) Samusik N. … Kozlov A.P. (PLoS ONE 2013) 67
  4. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou M.A. … Kyriacou K. (Breast Cancer Res. Treat. 2010) 67
  5. Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. (PMID: 17656261) Doak S.H. … Parry J.M. (Cancer Genet. Cytogenet. 2007) 67

Products for PBOV1 Gene

Sources for PBOV1 Gene

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