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Aliases for PBOV1 Gene

Aliases for PBOV1 Gene

  • Prostate And Breast Cancer Overexpressed 1 2 3 5
  • UROC28 3 4
  • UC28 3 4
  • Prostate And Breast Cancer Overexpressed Gene 1 Protein 3
  • Protein UROC28 4
  • DJ171N11.2 3

External Ids for PBOV1 Gene

Previous GeneCards Identifiers for PBOV1 Gene

  • GC06M138472
  • GC06M138517
  • GC06M138578

Summaries for PBOV1 Gene

Entrez Gene Summary for PBOV1 Gene

  • This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. [provided by RefSeq, Aug 2011]

GeneCards Summary for PBOV1 Gene

PBOV1 (Prostate And Breast Cancer Overexpressed 1) is a Protein Coding gene.

Additional gene information for PBOV1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBOV1 Gene

Genomics for PBOV1 Gene

Regulatory Elements for PBOV1 Gene

Enhancers for PBOV1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H138257 1.1 ENCODE dbSUPER 10.9 -40.0 -40041 2.2 ELF3 FOXA2 MLX ARID4B DMAP1 RARA CREM MIXL1 MIER2 PPARG PBOV1 ARFGEF3 GC06P138340
GH06H138194 0.7 ENCODE dbSUPER 11.1 +23.9 23873 0.6 ZNF362 POLR2A ATF2 PBOV1 ARFGEF3
GH06H138297 0.7 ENCODE 10.4 -79.8 -79782 1 TFAP4 FOXA2 SAP130 NFYC CEBPG ZNF644 THRB TEAD3 JUND CEBPA PERP PBOV1 GC06P138340
GH06H138267 0.6 dbSUPER 11.2 -50.2 -50168 1.6 SOX5 TAF1 REST YY1 TEAD3 ZGPAT HNF1A HNF4A BCL6 PRDM1 PBOV1 GC06P138340
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PBOV1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PBOV1 Gene

Genomic Locations for PBOV1 Gene
2,506 bases
Minus strand

Genomic View for PBOV1 Gene

Genes around PBOV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBOV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBOV1 Gene

Proteins for PBOV1 Gene

  • Protein details for PBOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prostate and breast cancer overexpressed gene 1 protein
    Protein Accession:

    Protein attributes for PBOV1 Gene

    135 amino acids
    Molecular mass:
    15722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PBOV1 Gene

Post-translational modifications for PBOV1 Gene

No Post-translational modifications

Other Protein References for PBOV1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBOV1 Gene

Domains & Families for PBOV1 Gene

Gene Families for PBOV1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PBOV1 Gene


Suggested Antigen Peptide Sequences for PBOV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PBOV1: view

No data available for UniProtKB/Swiss-Prot for PBOV1 Gene

Function for PBOV1 Gene

genes like me logo Genes that share phenotypes with PBOV1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PBOV1 Gene

Localization for PBOV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBOV1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PBOV1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PBOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PBOV1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PBOV1 Gene

Pathways & Interactions for PBOV1 Gene

SuperPathways for PBOV1 Gene

No Data Available

Interacting Proteins for PBOV1 Gene

Gene Ontology (GO) - Biological Process for PBOV1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PBOV1 Gene

Drugs & Compounds for PBOV1 Gene

No Compound Related Data Available

Transcripts for PBOV1 Gene

mRNA/cDNA for PBOV1 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PBOV1 Gene

No ASD Table

Relevant External Links for PBOV1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PBOV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PBOV1 Gene

mRNA differential expression in normal tissues according to GTEx for PBOV1 Gene

This gene is overexpressed in Brain - Cerebellum (x10.4) and Brain - Cerebellar Hemisphere (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of PBOV1 Gene:


SOURCE GeneReport for Unigene cluster for PBOV1 Gene:


mRNA Expression by UniProt/SwissProt for PBOV1 Gene:

Tissue specificity: Expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary, and peripheral blood leukocytes. Up-regulated expression in prostate, breast, and bladder cancer, but not in lung and colon cancer.
genes like me logo Genes that share expression patterns with PBOV1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PBOV1 Gene

Orthologs for PBOV1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PBOV1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PBOV1 33
  • 99.75 (n)
Species where no ortholog for PBOV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PBOV1 Gene

Gene Tree for PBOV1 (if available)
Gene Tree for PBOV1 (if available)

Paralogs for PBOV1 Gene

No data available for Paralogs for PBOV1 Gene

Variants for PBOV1 Gene

Sequence variations from dbSNP and Humsavar for PBOV1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001295795 -- 138,217,649(+) CTAGC(A/G)GAGCA intron-variant, utr-variant-3-prime
rs1002749961 -- 138,215,896(+) AGAGA(A/G)AGAGA intron-variant, downstream-variant-500B
rs1004831125 -- 138,219,654(+) GAGAG(G/T)GAAAG intron-variant, upstream-variant-2KB
rs1004881953 -- 138,219,308(+) ATAGT(A/G)GACGA intron-variant, upstream-variant-2KB
rs1005700290 -- 138,216,558(+) AAGTT(C/T)CTTCA intron-variant, utr-variant-3-prime

Variation tolerance for PBOV1 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBOV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PBOV1 Gene

Disorders for PBOV1 Gene

Relevant External Links for PBOV1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PBOV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PBOV1 Gene

Publications for PBOV1 Gene

  1. Enhanced expression of the UROC28 gene in human breast cancer: relationship to ERBB2 gene expression. (PMID: 12553037) Kamagata C … Watanabe N (Anticancer research 2002) 2 3 22 60
  2. Cloning and characterization of UROC28, a novel gene overexpressed in prostate, breast, and bladder cancers. (PMID: 11156405) An G … Veltri RW (Cancer research 2000) 2 3 4 60
  3. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou MA … Kyriacou K (Breast cancer research and treatment 2010) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60

Products for PBOV1 Gene

Sources for PBOV1 Gene

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