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Aliases for PBLD Gene

Aliases for PBLD Gene

  • Phenazine Biosynthesis Like Protein Domain Containing 2 3
  • Phenazine Biosynthesis-Like Protein Domain Containing 2 3 5
  • MAWD-Binding Protein 3 4
  • MAWDBP 3 4
  • MAWBP 3 4
  • Unknown Protein 32 From 2D-Page Of Liver Tissue 4
  • Epididymis Secretory Protein Li 306 3
  • MAWD Binding Protein 2
  • EC 5.1.-.- 4
  • HEL-S-306 3

External Ids for PBLD Gene

Previous GeneCards Identifiers for PBLD Gene

  • GC10M069713
  • GC10M070042
  • GC10M064042

Summaries for PBLD Gene

GeneCards Summary for PBLD Gene

PBLD (Phenazine Biosynthesis Like Protein Domain Containing) is a Protein Coding gene. GO annotations related to this gene include isomerase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBLD Gene

Genomics for PBLD Gene

Regulatory Elements for PBLD Gene

Enhancers for PBLD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PBLD on UCSC Golden Path with GeneCards custom track

Genomic Location for PBLD Gene

68,282,660 bp from pter
68,333,049 bp from pter
50,390 bases
Minus strand

Genomic View for PBLD Gene

Genes around PBLD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBLD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBLD Gene

Proteins for PBLD Gene

  • Protein details for PBLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phenazine biosynthesis-like domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A8MZJ3
    • C9JIM0
    • Q9HCC2

    Protein attributes for PBLD Gene

    288 amino acids
    Molecular mass:
    31785 Da
    Quaternary structure:
    • Interacts with UNRIP/MAWD.
    • Sequence=BAB55285.1; Type=Frameshift; Positions=232; Evidence={ECO:0000305};

    Alternative splice isoforms for PBLD Gene


neXtProt entry for PBLD Gene

Proteomics data for PBLD Gene at MOPED

Post-translational modifications for PBLD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBLD Gene

No data available for DME Specific Peptides for PBLD Gene

Domains & Families for PBLD Gene

Protein Domains for PBLD Gene

Suggested Antigen Peptide Sequences for PBLD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PhzF family.
  • Belongs to the PhzF family.
genes like me logo Genes that share domains with PBLD: view

No data available for Gene Families for PBLD Gene

Function for PBLD Gene

Enzyme Numbers (IUBMB) for PBLD Gene

Gene Ontology (GO) - Molecular Function for PBLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PBLD: view

Phenotypes for PBLD Gene

GenomeRNAi human phenotypes for PBLD:
genes like me logo Genes that share phenotypes with PBLD: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PBLD Gene

Localization for PBLD Gene

Subcellular locations from

Jensen Localization Image for PBLD Gene COMPARTMENTS Subcellular localization image for PBLD gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PBLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17929853
genes like me logo Genes that share ontologies with PBLD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PBLD Gene

Pathways & Interactions for PBLD Gene

SuperPathways for PBLD Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009058 biosynthetic process IEA --
GO:0010633 negative regulation of epithelial cell migration IMP 23687415
GO:0060392 negative regulation of SMAD protein import into nucleus IGI 23687415
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IMP 23687415
genes like me logo Genes that share ontologies with PBLD: view

No data available for Pathways by source and SIGNOR curated interactions for PBLD Gene

Drugs & Compounds for PBLD Gene

No Compound Related Data Available

Transcripts for PBLD Gene

Unigene Clusters for PBLD Gene

Phenazine biosynthesis-like protein domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PBLD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - -

Relevant External Links for PBLD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PBLD Gene

mRNA expression in normal human tissues for PBLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PBLD Gene

This gene is overexpressed in Liver (x15.1) and Kidney - Cortex (x6.4).

Protein differential expression in normal tissues from HIPED for PBLD Gene

This gene is overexpressed in Kidney (15.2), Liver, secretome (14.0), Liver (10.5), Fetal Liver (9.0), and Fetal gut (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PBLD Gene

SOURCE GeneReport for Unigene cluster for PBLD Gene Hs.198158

genes like me logo Genes that share expression patterns with PBLD: view

Protein tissue co-expression partners for PBLD Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PBLD Gene

Orthologs for PBLD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PBLD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PBLD 35
  • 86.46 (n)
  • 87.5 (a)
  • 88 (a)
(Canis familiaris)
Mammalia PBLD 35
  • 88.43 (n)
  • 90.62 (a)
  • 83 (a)
(Mus musculus)
Mammalia Pbld1 35
  • 80.32 (n)
  • 83.68 (a)
Pbld1 16
Pbld1 36
  • 84 (a)
Pbld2 36
  • 81 (a)
(Pan troglodytes)
Mammalia PBLD 35
  • 99.54 (n)
  • 98.96 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pbld1 35
  • 80.56 (n)
  • 84.03 (a)
(Monodelphis domestica)
Mammalia PBLD 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia PBLD 36
  • 77 (a)
(Gallus gallus)
Aves PBLD 35
  • 71.08 (n)
  • 72.82 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
-- 36
  • 70 (a)
(Danio rerio)
Actinopterygii zgc:112210 35
  • 61.03 (n)
  • 56.69 (a)
PBLD (1 of 2) 36
  • 56 (a)
PBLD (2 of 2) 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9410 35
(Caenorhabditis elegans)
Secernentea CELE_T04A11.2 35
  • 51.35 (n)
  • 43.11 (a)
R02D1.2 36
  • 35 (a)
T04A11.1 36
  • 36 (a)
T04A11.2 36
  • 38 (a)
T04A11.4 36
  • 36 (a)
T04A11.5 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YHI9 36
  • 27 (a)
YHI9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02860 35
  • 48.54 (n)
  • 44.49 (a)
(Oryza sativa)
Liliopsida Os01g0266500 35
  • 48.63 (n)
  • 45.52 (a)
Species with no ortholog for PBLD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PBLD Gene

Gene Tree for PBLD (if available)
Gene Tree for PBLD (if available)

Paralogs for PBLD Gene Pseudogenes for PBLD Gene

genes like me logo Genes that share paralogs with PBLD: view

No data available for Paralogs for PBLD Gene

Variants for PBLD Gene

Sequence variations from dbSNP and Humsavar for PBLD Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12359690 - 68,306,796(+) CCCAC(A/G)AAATG reference, missense
rs4142048 - 68,284,274(-) TTCCC(A/G)CCGAG reference, missense
VAR_072403 -
rs1807347 -- 68,283,964(-) TTCGA(C/T)ACCAG downstream-variant-500B, utr-variant-3-prime
rs1867568 -- 68,328,868(-) AAACC(A/G)CTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBLD Gene

Variant ID Type Subtype PubMed ID
nsv437125 CNV Loss 16327808
nsv517615 CNV Loss 19592680
esv2738017 CNV Deletion 23290073
dgv150e199 CNV Deletion 23128226
dgv158n67 CNV Loss 20364138

Variation tolerance for PBLD Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PBLD Gene

Disorders for PBLD Gene

Relevant External Links for PBLD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PBLD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PBLD Gene

Publications for PBLD Gene

  1. Cloning and sequencing of a novel human gene which encodes a putative hydroxylase. (PMID: 11355021) Iriyama C. … Hamaguchi M. (J. Hum. Genet. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for PBLD Gene

Sources for PBLD Gene