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PBK Gene

protein-coding   GIFtS: 61
GCID: GC08M027724

PDZ Binding Kinase

  See PBK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PDZ Binding Kinase1 2     MAPKK-Like Protein Kinase2 3
T-LAK Cell-Originated Protein Kinase1 2 3     HEL1642
Cancer/Testis Antigen 841 2 3     Epididymis Luminal Protein 1642
TOPK2 3 5     Lymphokine-Activated Killer T-Cell-Originated Protein Kinase2
Spermatogenesis-Related Protein Kinase2 3     Serine/Threonine Protein Kinase2
CT842 3     EC 2.7.12.23
Nori-32 3     PDZ-Binding Kinase3
SPK2 3     

External Ids:    HGNC: 182821   Entrez Gene: 558722   Ensembl: ENSG000001680787   OMIM: 6112105   UniProtKB: Q96KB53   

Export aliases for PBK gene to outside databases

Previous GC identifer: GC08M026212


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PBK Gene:
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase
kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The
encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a
suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in
tumorigenesis. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for PBK Gene:
PBK (PDZ binding kinase) is a protein-coding gene. Diseases associated with PBK include corneal edema, and plexiform neurofibroma. GO annotations related to this gene include protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot: TOPK_HUMAN, Q96KB5
Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the
activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and
attenuation of G2/M checkpoint during doxorubicin-induced DNA damage

Gene Wiki entry for PBK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PBK gene promoter:
         PPAR-gamma1   AML1a   AP-1   ATF-2   CUTL1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPBK promoter sequence
   Search Chromatin IP Primers for PBK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PBK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21.2

PBK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PBK gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M027724:  view genomic region     (about GC identifiers)

Start:
27,667,137 bp from pter      End:
27,695,612 bp from pter
Size:
28,476 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TOPK_HUMAN, Q96KB5 (See protein sequence)
Recommended Name: Lymphokine-activated killer T-cell-originated protein kinase  
Size: 322 amino acids; 36085 Da
Subunit: Interacts with DLG1 and TP53
Secondary accessions: D3DST2 Q9NPD9 Q9NYL7 Q9NZK6

Explore the universe of human proteins at neXtProt for PBK: NX_Q96KB5

Explore proteomics data for PBK at MOPED

Post-translational modifications: 

  • Phosphorylated; in a cell-cycle dependent manner at mitosis1
  • Ubiquitination2 at Lys90, Lys132
  • Modification sites at PhosphoSitePlus

  • See PBK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265874.1  NP_060962.2  

    ENSEMBL proteins: 
     ENSP00000301905   ENSP00000428489   ENSP00000428438   ENSP00000427892  

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    antibodies-online peptides for PBK

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PDZ binding kinase
    TOPK family

    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96KB5

    ProtoNet protein and cluster: Q96KB5

    UniProtKB/Swiss-Prot: TOPK_HUMAN, Q96KB5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PBK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOPK_HUMAN, Q96KB5
    Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the
    activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and
    attenuation of G2/M checkpoint during doxorubicin-induced DNA damage
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation (By similarity)

         Enzyme Number (IUBMB): EC 2.7.12.21

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS10779557
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10779557
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PBK           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PBK:
     Decreased focal adhesion (FA)   Increased G1 DNA content  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pbk):
     immune system  integument 

    Find genes that share phenotypes with PBK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pbktm1Zgdo for PBK

       genOway: Develop your customized and physiologically relevant rodent model for PBK

    miRNA
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    miRTarBase miRNAs that target PBK:
    hsa-mir-373-3p (MIRT004449)

    Block miRNA regulation of human, mouse, rat PBK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PBK (see all 20):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidPBK 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with PBK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PBK About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32


    Find genes that share SuperPaths with PBK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PBK
        Cell Cycle / Checkpoint Control
    DNA Damage



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PBK
    Interactions:

        Search GeneGlobe Interaction Network for PBK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for PBK (Q96KB51, 2, 3 ENSP000003019054) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129592, 3, ENSP000003457314MINT-1792398 MINT-1792484 MINT-1792509 MINT-72801 MINT-72803 MINT-72835 MINT-72834 I2D: score=3 STRING: ENSP00000345731
    TRIM37O949722, 3, ENSP000002622944MINT-68244 I2D: score=5 STRING: ENSP00000262294
    TP53P046371, 3, ENSP000002693054EBI-536853,EBI-366083 I2D: score=3 STRING: ENSP00000269305
    MBPP026862, 3, ENSP000003482734MINT-1792581 I2D: score=1 STRING: ENSP00000348273
    GPS2Q132272, 3MINT-65224 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis NAS10779557

    Find genes that share ontologies with PBK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PBK (TOPK)

    2 HMDB Compounds for PBK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PBK gene (2 alternative transcripts): 
    NM_001278945.1  NM_018492.3  

    Unigene Cluster for PBK:

    PDZ binding kinase
    Hs.104741  [show with all ESTs]
    Unigene Representative Sequence: NM_018492
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301905(uc003xgi.3 uc011lap.2) ENST00000522944 ENST00000524266
    ENST00000521226
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PBK (see all 20):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidPBK 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB027249.1 AB027250.1 AF189722.1 AF237709.1 AK027291.1 AK301836.1 BC015191.1 

    6 DOTS entries:

    DT.441425  DT.100028663  DT.121483606  DT.95359350  DT.97854753  DT.95151126 

    Selected AceView cDNA sequences (see all 169):

    CB143138 AA737663 AI276896 BM788435 AU279451 W25389 AA651780 BU616852 
    CA425608 CB959725 AA405512 BC015191 CR602995 AI287319 AA830977 AA768652 
    CR623970 AI278471 AI393315 NM_018492 BX281040 BU928327 BU616941 AW269502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PBK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGACTTAAA
    PBK Expression
    About this image


    PBK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Pre-Sertoli Cells Testis Cord
             Testis Interstitium
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    PBK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PBK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104741

    UniProtKB/Swiss-Prot: TOPK_HUMAN, Q96KB5
    Tissue specificity: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell
    layer of seminiferous tubules

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PBK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pbk1 , 5 PDZ binding kinase1, 5 87.19(n)1
    88.44(a)1
      14 (34.36 cM)5
    520331  NM_023209.21  NP_075698.11 
     658058375 
    chicken
    (Gallus gallus)
    Aves PBK1 PDZ binding kinase 71.37(n)
    75(a)
      422003  NM_001277999.1  NP_001264928.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    69(a)
    56(a)
    many → 1
    many → 1
    GL344167.1(27430-41103)
    1(207553855-207555593)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851440.12   -- 76.34(n)    BX851440.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pbk1 PDZ binding kinase 66.03(n)
    67.41(a)
      360218  NM_001002387.1  NP_001002387.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81731 CG8173 52.14(n)
    46.15(a)
      32753  NM_133011.2  NP_573239.1 


    ENSEMBL Gene Tree for PBK (if available)
    TreeFam Gene Tree for PBK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PBK (see all 848)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415232891,2
    C--27666794(+) TGCAAA/GTTAAT 1 -- ds50010--------
    rs101054201,2
    C,F,H--27666843(+) GCCTTC/TAGTGA 1 -- ds500120Minor allele frequency- T:0.24NS EA NA WA CSA 2346
    rs170578881,2
    C,F--27667006(+) TGGCTT/CACAGA 1 -- ds500111Minor allele frequency- C:0.20NA WA CSA EA 510
    rs100950511,2
    C,F,A--27667035(+) CTTTAT/CAGATT 1 -- ds500111Minor allele frequency- C:0.20NA WA CSA EA 508
    rs574488741,2
    C--27667139(+) CACCTTCT/-GGTAC 1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs1457542661,2
    C--27667185(+) GAGTTC/TTATTG 1 -- ut310--------
    rs100920961,2
    C,F--27667209(+) GGGAAA/GTGCTT 1 -- ut312Minor allele frequency- G:0.08WA 120
    rs1494493931,2
    C--27667281(+) AACCA-/AAGAAGAT 1 -- cds10--------
    rs605768791,2
    C--27667282(+) AAAGA-/AA    
       G
    /AGA
    TCTGA
    2 -- cds10--------
    rs1862762471,2
    --27667308(+) GATCAA/GGACAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PBK (27667137 - 27695612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PBK (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4741CNV Deletion18987735
    esv2736802CNV Deletion23290073
    esv2736801CNV Deletion23290073
    esv2668206CNV Deletion23128226
    esv2736800CNV Deletion23290073
    nsv824582CNV Loss20364138
    nsv524133CNV Loss19592680
    nsv398258CNV Loss16902084
    nsv890700CNV Loss21882294
    esv23502CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611210    OMIM disorders: --

    2 diseases for PBK:    
    About MalaCards
    corneal edema    plexiform neurofibroma

    2 diseases from the University of Copenhagen DISEASES database for PBK:
    Corneal edema     Keratopathy

    Find genes that share disorders with PBK           About GenesLikeMe

    3 Novoseek inferred disease relationships for PBK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hematologic malignancies 39.6 2 14757441 (1), 16171862 (1)
    tumors 0 2 10781613 (1), 19945431 (1)
    cancer 0 2 19945431 (4), 19954816 (1), 19900192 (1)

    Genetic Association Database (GAD): PBK
    Human Genome Epidemiology (HuGE) Navigator: PBK (3 documents)

    Export disorders for PBK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PBK gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with PBK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. (PubMed id 10781613)1, 2, 3, 9 Abe Y.... Ueda N. (J. Biol. Chem. 2000)
    2. Characterization of PDZ-binding kinase, a mitotic kinase. (PubMed id 10779557)1, 2, 3, 9 Gaudet S.... Lue R.A. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    3. PDZ-binding kinase participates in spermatogenesis. (PubMed id 11378444)1, 2, 9 Zhao S.... Mao Y. (Int. J. Biochem. Cell Biol. 2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    6. Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. (PubMed id 17482142)1, 2 Nandi A.K.... Rapoport A.P. (Biochem. Biophys. Res. Commun. 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Critical roles of T-LAK cell-originated protein kinase in cytokinesis. (PubMed id 19900192)1, 9 Park J.H....Katagiri T. (Cancer Sci. 2010)
    10. Characterization of a MAPKK-like protein kinase TOPK. (PubMed id 15541388)1, 9 Matsumoto S....Gyo K. (Biochem. Biophys. Res. Commun. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55872 HGNC: 18282 AceView: TOPK Ensembl:ENSG00000168078 euGenes: HUgn55872
    ECgene: PBK H-InvDB: PBK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PBK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PBK gene:
    Search GeneIP for patents involving PBK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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