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Aliases for PBK Gene

Aliases for PBK Gene

  • PDZ Binding Kinase 2 3
  • T-LAK Cell-Originated Protein Kinase 2 3 4
  • Cancer/Testis Antigen 84 2 3 4
  • TOPK 3 4 6
  • Spermatogenesis-Related Protein Kinase 3 4
  • MAPKK-Like Protein Kinase 3 4
  • Nori-3 3 4
  • CT84 3 4
  • SPK 3 4
  • Lymphokine-Activated Killer T-Cell-Originated Protein Kinase 3
  • Serine/Threonine Protein Kinase 3
  • Epididymis Luminal Protein 164 3
  • PDZ-Binding Kinase 4
  • EC 2.7.12.2 4
  • HEL164 3

External Ids for PBK Gene

Summaries for PBK Gene

Entrez Gene Summary for PBK Gene

  • This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PBK Gene

PBK (PDZ Binding Kinase) is a Protein Coding gene. Diseases associated with PBK include corneal edema and plexiform neurofibroma. Among its related pathways are Cell Cycle / Checkpoint Control and Cell Cycle / Checkpoint Control. GO annotations related to this gene include protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for PBK Gene

  • Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Gene Wiki entry for PBK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBK Gene

Genomics for PBK Gene

Genomic Location for PBK Gene

Start:
27,809,620 bp from pter
End:
27,838,095 bp from pter
Size:
28,476 bases
Orientation:
Minus strand

Genomic View for PBK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PBK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBK Gene

Regulatory Elements for PBK Gene

Proteins for PBK Gene

  • Protein details for PBK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KB5-TOPK_HUMAN
    Recommended name:
    Lymphokine-activated killer T-cell-originated protein kinase
    Protein Accession:
    Q96KB5
    Secondary Accessions:
    • B4DX68
    • D3DST2
    • Q9NPD9
    • Q9NYL7
    • Q9NZK6

    Protein attributes for PBK Gene

    Size:
    322 amino acids
    Molecular mass:
    36085 Da
    Quaternary structure:
    • Interacts with DLG1 and TP53.

    Alternative splice isoforms for PBK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PBK Gene

Proteomics data for PBK Gene at MOPED

Post-translational modifications for PBK Gene

  • Phosphorylated; in a cell-cycle dependent manner at mitosis.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys90 and Lys132

Other Protein References for PBK Gene

No data available for DME Specific Peptides for PBK Gene

Domains for PBK Gene

Gene Families for PBK Gene

Protein Domains for PBK Gene

UniProtKB/Swiss-Prot:

TOPK_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q96KB5
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.:
    • Q96KB5
genes like me logo Genes that share domains with PBK: view

Function for PBK Gene

Molecular function for PBK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation.
UniProtKB/Swiss-Prot Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Enzyme Numbers (IUBMB) for PBK Gene

Gene Ontology (GO) - Molecular Function for PBK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS 10779557
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10779557
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PBK: view
genes like me logo Genes that share phenotypes with PBK: view

Animal Models for PBK Gene

MGI Knock Outs for PBK:

miRNA for PBK Gene

miRTarBase miRNAs that target PBK

No data available for Transcription Factor Targeting and HOMER Transcription for PBK Gene

Localization for PBK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBK Gene COMPARTMENTS Subcellular localization image for PBK gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PBK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PBK: view

Pathways for PBK Gene

genes like me logo Genes that share pathways with PBK: view

Pathways by source for PBK Gene

2 Cell Signaling Technology pathways for PBK Gene

Gene Ontology (GO) - Biological Process for PBK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007067 mitotic nuclear division NAS 10779557
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0032873 negative regulation of stress-activated MAPK cascade IEA --
genes like me logo Genes that share ontologies with PBK: view

Compounds for PBK Gene

(2) HMDB Compounds for PBK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with PBK: view

Transcripts for PBK Gene

Unigene Clusters for PBK Gene

PDZ binding kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PBK Gene

No ASD Table

Relevant External Links for PBK Gene

GeneLoc Exon Structure for
PBK
ECgene alternative splicing isoforms for
PBK

Expression for PBK Gene

mRNA expression in normal human tissues for PBK Gene

mRNA differential expression in normal tissues according to GTEx for PBK Gene

This gene is overexpressed in Testis (17.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PBK Gene

SOURCE GeneReport for Unigene cluster for PBK Gene Hs.104741

mRNA Expression by UniProt/SwissProt for PBK Gene

Q96KB5-TOPK_HUMAN
Tissue specificity: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
genes like me logo Genes that share expressions with PBK: view

Orthologs for PBK Gene

This gene was present in the common ancestor of animals.

Orthologs for PBK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBK 36
  • 99.38 (n)
  • 99.07 (a)
PBK 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 81 (a)
OneToMany
PBK 36
  • 91.3 (n)
  • 89.44 (a)
PBK 37
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 94 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
PBK 36
  • 92.96 (n)
  • 94.1 (a)
mouse
(Mus musculus)
Mammalia Pbk 36
  • 87.19 (n)
  • 88.44 (a)
Pbk 16
Pbk 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PBK 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pbk 36
  • 88.16 (n)
  • 90.97 (a)
chicken
(Gallus gallus)
Aves PBK 36
  • 71.37 (n)
  • 75 (a)
PBK 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 56 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pbk 36
  • 66.67 (n)
  • 70.31 (a)
Str.5851 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11180 36
zebrafish
(Danio rerio)
Actinopterygii pbk 36
  • 66.03 (n)
  • 67.41 (a)
pbk 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8173 36
  • 52.14 (n)
  • 46.15 (a)
CG8173 37
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.54 37
  • 45 (a)
OneToOne
Species with no ortholog for PBK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PBK Gene

ENSEMBL:
Gene Tree for PBK (if available)
TreeFam:
Gene Tree for PBK (if available)

Paralogs for PBK Gene

No data available for Paralogs for PBK Gene

Variants for PBK Gene

Sequence variations from dbSNP and Humsavar for PBK Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs482754 -- 27,829,287(-) ctcta(G/T)ctcat intron-variant
rs493170 -- 27,833,504(+) AACTC(C/T)GTCTC intron-variant
rs493234 -- 27,833,526(+) aaaGC(A/C)TATAA intron-variant
rs500529 -- 27,833,482(-) gccca(A/C/G)gctgg intron-variant
rs506737 -- 27,832,622(-) AATTT(A/C)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBK Gene

Variant ID Type Subtype PubMed ID
nsv890699 CNV Gain 21882294
nsv524133 CNV Loss 19592680
nsv519636 CNV Gain 19592680
nsv890700 CNV Loss 21882294
esv2736800 CNV Deletion 23290073
esv4741 CNV Deletion 18987735
esv2736801 CNV Deletion 23290073
esv2668206 CNV Deletion 23128226
nsv398258 CNV Loss 16902084
esv23502 CNV Loss 19812545
esv2736802 CNV Deletion 23290073
nsv824582 CNV Loss 20364138

Relevant External Links for PBK Gene

HapMap Linkage Disequilibrium report
PBK

Disorders for PBK Gene

(2) University of Copenhagen DISEASES for PBK Gene

(3) Novoseek inferred disease relationships for PBK Gene

Disease -log(P) Hits PubMed IDs
hematologic malignancies 39.6 2
tumors 0 2
cancer 0 6

Relevant External Links for PBK

Genetic Association Database (GAD)
PBK
Human Genome Epidemiology (HuGE) Navigator
PBK
genes like me logo Genes that share disorders with PBK: view

No data available for UniProtKB/Swiss-Prot for PBK Gene

Publications for PBK Gene

  1. Characterization of PDZ-binding kinase, a mitotic kinase. (PMID: 10779557) Gaudet S. … Lue R.A. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23
  2. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. (PMID: 10781613) Abe Y. … Ueda N. (J. Biol. Chem. 2000) 2 3 4 23
  3. PDZ-binding kinase participates in spermatogenesis. (PMID: 11378444) Zhao S. … Mao Y. (Int. J. Biochem. Cell Biol. 2001) 3 4 23
  4. Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. (PMID: 14757441) Nandi A. … Rapoport A.P. (Blood Cells Mol. Dis. 2004) 3 23
  5. Characterization of a MAPKK-like protein kinase TOPK. (PMID: 15541388) Matsumoto S. … Gyo K. (Biochem. Biophys. Res. Commun. 2004) 3 23

Products for PBK Gene

  • Addgene plasmids for PBK

Sources for PBK Gene

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