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PAX4 Gene

protein-coding GIFtS: 66

GC07M127037

paired box 4
(Previous name: paired box gene 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KPD ^², ⁵
MGC129960 ^²
MODY9 ^², ⁵

Descriptions
paired box 4 ^²
paired box gene 4 ^¹, ²
paired domain gene 4 ^²

External Ids
HGNC: 8618¹
Entrez Gene: 5078²
UniProtKB: O43316³
Ensembl: ENSG00000106331⁷

Search outside databases for aliases for PAX4 gene

Previous GC identifers: GC07M125728 GC07M126791 GC07M126804 GC07M126844

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAX4:

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene

family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These

genes play critical roles during fetal development and cancer growth. The paired box 4 gene is

involved in pancreatic islet development and mouse studies have demonstrated a role for this gene

in differentiation of insulin-producing beta cells. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAX4_HUMAN, O43316

Function: Plays an important role in the differentiation and development of pancreatic islet beta

cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and

somatostatin promoters. Competes with PAX6 for this same promoter binding site. The Pax4v isoform

appears to be a dominant negative form antagonizing PAX4 transcriptional activity

Gene Wiki entry for PAX4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAX4 gene

Entrez Gene cytogenetic band: 7q32 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q32.1

PAX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M127037: (about GC identifiers)

Start:	127,037,582 bp from pter
End:	127,043,218 bp from pter
Size:	5,637 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 126,633,785-126,639,226

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAX4_HUMAN, O43316 (See protein sequence)

Recommended Name: Paired box protein Pax-4

Size: 350 amino acids; 37833 Da

Subcellular location: Nucleus

Sequence caution: Sequence=AC073934; Type=Miscellaneous discrepancy; Note=According to the human

genome assembly there is a stop codon in position 349;

Secondary accessions: O95161 Q6B0H0

Alternative splicing: 3 isoforms: O43316-1 O43316-2 O43316-4

REFSEQ proteins: NP_006184.2

ENSEMBL proteins:

ENSP00000368014 ENSP00000339906 ENSP00000344297

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PAX4)
	Human Recombinant Proteins from Abnova (PAX4)

OriGene Purified Recombinant Human Protein: PAX4

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for PAX4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PAX4
	R&D Systems Antibodies for PAX4
	Antibodies from Abcam (PAX4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAX4)
	Novus Biologicals Antibody for PAX4

Assays for PAX4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O43316

ProtoNet protein and cluster: O43316

1 Blocks protein family: IPB001523 Paired box protein

UniProtKB/Swiss-Prot: PAX4_HUMAN, O43316

Similarity: Belongs to the paired homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 paired domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAX4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAX4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006193

Applied Biosystems Silencer® siRNAs for PAX4

Sigma-Aldrich siRNA for PAX4

Sigma-Aldrich shRNA for PAX4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006193
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006193
untagged cDNA clone in CMV expression vector: NM_006193

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006193

UniProtKB/Swiss-Prot: PAX4_HUMAN, O43316

Function: Plays an important role in the differentiation and development of pancreatic islet beta

cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and

somatostatin promoters. Competes with PAX6 for this same promoter binding site. The Pax4v isoform

appears to be a dominant negative form antagonizing PAX4 transcriptional activity

Genatlas biochemistry entry for PAX4:

paired box (DNA binding) containing protein 4,with homeo domain,predominantly expressed in placenta

and skeletal muscle,also expressed in heart and pancreas,essential for differentiation of

insulin-producing beta-cells

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pax4):

digestive/alimentary

endocrine/exocrine gland

growth/size

lethality-postnatal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PAX4

5/10 Interacting proteins for PAX4 (ENSP00000368014³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INS	ENSP00000370731³	STRING (score=.983)
NEUROG3	ENSP00000242462³	STRING (score=.972)
GCG	ENSP00000364647³	STRING (score=.971)
INHBE	ENSP00000266646³	STRING (score=.949)
SLC2A2	ENSP00000323568³	STRING (score=.887)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0009887	organ morphogenesis	TAS	9480859
GO:0030154	cell differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAX4
1 Novoseek chemical compound relationship for PAX4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	39.06	8	17003335 (2), 17989064 (2), 12200761 (1), 11825903 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAX4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAX4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006193

Sigma-Aldrich siRNA for PAX4

Sigma-Aldrich shRNA for PAX4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006193

REFSEQ mRNAs for PAX4 gene:

NM_006193.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006193

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006193
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006193
                                 untagged cDNA clone in CMV expression vector: NM_006193

Additional cDNA sequence:

AB008913.1 AF043978.1 BC074761.2 BC107149.2 BC107150.1 DQ442656.1

1 DOTS entry:

DT.91748890

5 AceView cDNA sequences:

AB008913 NM_006193 AF043978 BC074761 BV198517

highest scoring ESTs for PAX4:

AB008913 AF043978 BC074761 NM_006193 BC107149 BC107150 DQ442656

Unigene Cluster for PAX4:

Paired box 4

Hs.129706

Unigene Representative Sequence: AF043978

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PAX4

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10
SP1:							-												-
SP2:							-												-				-
SP3:

About this scheme

ECgene alternative splicing isoforms for PAX4

3 Ensembl transcripts including schematic representations:

ENST00000378740 ENST00000341640 ENST00000338516

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAX4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAX4

¹ / ² / ³

6 probe-sets matching PAX4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31740_s_at²^{, 3}	U95-A	1	1.00	1.00	0.45	1.49	AB008913	1.00	1.00	1.00	1
31741_at²^{, 3}	U95-A	1	1.00	1.00	0.71	0.55	AF043978	1.00	1.00	1.00	1
207867_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006193	0.60	1.00	0.82	1
211176_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB008913	1.00	1.00	1.00	1
207867_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211176_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PAX4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CATCCCCAAA

SOURCE GeneReport for Unigene cluster: Hs.129706
Expression variation in blood from EXPOLDB for PAX4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAX4 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAX4¹	--	paired box 4	90.2(n) 89.02(a)	482268 XM_539387.2 XP_539387.2
chimpanzee (Pan troglodytes)	PAX4¹	--	paired box 4	99.42(n) 99.42(a)	472503 XM_001151306.1 XP_001151306.1
rat (Rattus norvegicus)	Pax4¹	--	paired box 4	82.21(n) 78.83(a)	83630 NM_031799.1 NP_113987.1
mouse (Mus musculus)	Pax4^{1, 5}	6 (9.00 cM)⁵	paired box gene 4^{1, 5}	81.39(n)¹ 78.53(a)¹	18506¹ NM_011038.1¹ NP_035168.1¹ AB008912⁵ AB010557⁵ (see all 17)

About this table Species with no ortholog for PAX4

ENSEMBL Gene Tree for PAX4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PAX4 gene

PAX7² PAX3² PAX6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/70 NCBI SNPs in PAX4 are shown (see all 70 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs712703^1,2	A,C,F,H,O	127044734(-)	`TTCTGA/GTGAGG`	1	--	ng3¹		12	EA NA EU WA	2272
	rs712700^1,2	A,C,F,H,O	127038143(-)	`ACACTG/AGCCTT`	1	--	ut3¹ ese³		8	MN EU EA NA	1535
	rs327516^1,2	A,C,F,H	127043031(+)	`CATACG/CCGCCA`	1	--	ng3¹		4	EU EA WA	412
	rs327512^1,2	A,C,F,H	127044487(+)	`CACCAA/GTGAAA`	1	--	ng3¹		4	EU EA WA	392
	rs327515^1,2	C,F,H	127043513(-)	`TTCAAG/TAAAGA`	1	--	ng3¹ tfbs³		15	EA NA NS EU WA	728
	rs712701^1,2	C,F,H	127038424(-)	`CTGTCC/ACCTGG`	1	P/H	mis¹ ese³		9	EU EA WA NA	912
	rs2233578^1,2	C,F,H	127041787(-)	`GCACAC/TGGCTC`	1	R/W	mis¹ ese³		12	NA EU EA WA	1048
	rs2233580^1,2	C,F,H	127040786(-)	`GGCCCA/GTGGAA`	1	R/H	mis¹ ese³		12	EU EA WA NA	1052
--	rs712699^1,2	A,C,F	127037833(+)	`ATAATA/GTCAgt`	1	--	ut3¹ ese³		3	NA	138
	rs327511^1,2	A,C,F	127044497(+)	`ACAAAG/TAATTA`	1	--	ng3¹		1	EA	1474

About this table

HapMap Linkage Disequilibrium images for PAX4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 167413 disorders: 612225 125853 612227

UniProtKB/Swiss-Prot: PAX4_HUMAN, O43316

Defects in PAX4 are a cause of noninsulin-dependent diabetes mellitus (NIDDM)

[MIM:125853]; also known as diabetes mellitus type 2 or maturity-onset diabetes. NIDDM is

characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin

resistance

Genetic variations in PAX4 are associated with susceptibility to insulin-dependent

diabetes mellitus (IDDM) [MIM:222100]. IDDM normally starts in childhood or adolescence and is

caused by the body's own immune system which destroys the insulin-producing beta cells in the

pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced

osmotic diuresis

Genetic variations in PAX4 are associated with susceptibility to ketosis-prone diabetes

mellitus (KPD) [MIM:612227]. KPD belongs to a rare subgroup of type 2 diabetes with severe insulin

deficiency, mostly observed in subjects of sub-Saharan African ancestry, such as west Africans,

Caribbeans and African-Americans. Its phenotype is distinct from the common type 2 and type 1

diabetes. It is characterized by a fulminant initial insulin dependence, without the immunological

markers observed in classical type 1 diabetes, followed by a subsequent clinical course which

varies from non-insulin treated type 2 diabetes to insulin-dependent idiopathic type 1 diabetes. A

severe dysfunction of the insulin-producing beta-cells is attested to by the observation that 25%

of the subjects are insulin dependent at diabetes onset, whereas the remaining 75% will develop

permanent insulin dependence within 10 years

Defects in PAX4 are the cause of maturity-onset diabetes of the young type 9 (MODY9)

[MIM:612225]. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal

dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin

secretion

8 Novoseek disease relationships for PAX4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
insulinoma	62.04	12	11263967 (5), 17260022 (4), 9480859 (1), 18234907 (1) (see all 5)
diabetes mellitus insulin-dependent	48.46	6	16132946 (1), 17633464 (1), 16132953 (1), 16132962 (1) (see all 6)
niddm	31.83	5	16423628 (3), 10967107 (1), 17426099 (1)
glucose intolerance	29.09	1	17003335 (1)
hyperglycemia	26.54	1	17989064 (1)
hyperinsulinemia	18.89	1	16988001 (1)
tumors	0.00	2	18949370 (2)
insulin resistance	0.00	3	12200761 (1), 12386964 (1)

About this table

Human Gene Mutation Database: PAX4
Genetic Association Database: PAX4
Human Genome Epidemiology Navigator: PAX4 (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/76 PubMed articles for PAX4 gene (see all 76 ):

Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. (PubMed id 15834548)^{1, 3, 4, 6} Biason-Lauber A....Schoenle E.J. (2005)
PAX4 gene variations predispose to ketosis-prone diabetes. (PubMed id 15509590)^{1, 3, 4, 6} Mauvais-Jarvis F....Vaisse C. (2004)
A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese. (PubMed id 11723072)^{1, 3, 4, 6} Shimajiri Y....Nanjo K. (2001)
Expression of dominant negative form of PAX4 in human insulinoma. (PubMed id 11263967)^{1, 3, 4} Miyamoto T....Hashizume K. (2001)
PAX4 mutations in Thais with maturity onset diabetes of the young. (PubMed id 17426099)^{1, 3, 4} Plengvidhya N....Banchuin N. (2007)
Lack of association of PAX4 gene with type 1 diabetes in the Finnish and Hungarian populations. (PubMed id 16123375)^{1, 3, 6} Hermann R....Ilonen J. (2005)
PAX4 mutation (R121W) as a prodiabetic variant in Okinawans. (PubMed id 12604352)^{1, 3, 6} Shimajiri Y....Takasu N. (2003)
Molecular cloning of mouse paired-box-containing gene (Pax-4) from an islet beta cell line and deduced sequence of human Pax-4. (PubMed id 9439631)^{1, 3, 4} Matsushita T....Itakura M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Isolation and characterization of the human PAX4 gene. (PubMed id 9753306)^{3, 4} Tao T.... Permutt M.A. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5078	HGNC: 8618	AceView: PAX4	Ensembl:ENSG00000106331	euGenes: HUgn5078
ECgene: PAX4	H-InvDB: PAX4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PAX4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PAX4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PAX4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAX4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAX4		Antibodies for PAX4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAX4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PAX4)
	Antibodies (PAX4)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (PAX4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for PAX4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PAX4

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PAX4 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for PAX4

Summaries
for PAX4

Genomic Location
for PAX4

Proteins
for PAX4

Protein Domains/
Families
for PAX4

Gene Function
for PAX4

Pathways & Interactions
for PAX4

Drugs & Compounds
for PAX4

Transcripts
for PAX4

Expression
for PAX4

Orthologs
for PAX4

Paralogs
for PAX4

SNPs/Variants
for PAX4

Disorders & Mutations
for PAX4

Medical News
for PAX4

Publications
for PAX4

Search for PAX4

Genome Databases showing PAX4

Other Databases showing PAX4

Specialized Databases showing PAX4

Licensable Technologies
for PAX4

Services
for PAX4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAX4 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor PAX4

Summariesfor PAX4

Genomic Locationfor PAX4

Proteinsfor PAX4

Protein Domains/Familiesfor PAX4

Gene Functionfor PAX4

Pathways & Interactionsfor PAX4

Drugs & Compoundsfor PAX4

Transcriptsfor PAX4

Expression for PAX4

Orthologsfor PAX4

Paralogsfor PAX4

SNPs/Variantsfor PAX4

Disorders & Mutationsfor PAX4

Medical Newsfor PAX4

Publicationsfor PAX4

Search for PAX4

Genome Databases showing PAX4

Other Databases showing PAX4

Specialized Databases showing PAX4

Licensable Technologiesfor PAX4

Servicesfor PAX4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAX4

Summaries
for PAX4

Genomic Location
for PAX4

Proteins
for PAX4

Protein Domains/
Families
for PAX4

Gene Function
for PAX4

Pathways & Interactions
for PAX4

Drugs & Compounds
for PAX4

Transcripts
for PAX4

Expression
for PAX4

Orthologs
for PAX4

Paralogs
for PAX4

SNPs/Variants
for PAX4

Disorders & Mutations
for PAX4

Medical News
for PAX4

Publications
for PAX4

Licensable Technologies
for PAX4

Services
for PAX4