Aliases for PAWR Gene
External Ids for PAWR Gene
Previous GeneCards Identifiers for PAWR Gene
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for PAWR Gene
PAWR (Pro-Apoptotic WT1 Regulator) is a Protein Coding gene. Diseases associated with PAWR include Prostate Cancer and Wilms Tumor Susceptibility-5. Among its related pathways are NF-kappaB Signaling and Ceramide signaling pathway. GO annotations related to this gene include enzyme binding and transcription corepressor activity.
UniProtKB/Swiss-Prot for PAWR Gene
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.