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Aliases for PAWR Gene

Aliases for PAWR Gene

  • Pro-Apoptotic WT1 Regulator 2 3
  • PRKC, Apoptosis, WT1, Regulator 2 3 5
  • Prostate Apoptosis Response 4 Protein 3 4
  • Prostate Apoptosis Response-4 2 3
  • PAR-4 3 4
  • PAR4 3 4
  • Prostate Apoptosis Response Protein PAR-4 3
  • Prostate Apoptosis Response Protein 4 3
  • Transcriptional Repressor PAR4 3
  • WT1-Interacting Protein 3

External Ids for PAWR Gene

Previous GeneCards Identifiers for PAWR Gene

  • GC12M079960
  • GC12M080349
  • GC12M078488
  • GC12M077042

Summaries for PAWR Gene

Entrez Gene Summary for PAWR Gene

  • The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAWR Gene

PAWR (Pro-Apoptotic WT1 Regulator) is a Protein Coding gene. Diseases associated with PAWR include Prostate Cancer and Wilms Tumor Susceptibility-5. Among its related pathways are NF-kappaB Signaling and Ceramide signaling pathway. GO annotations related to this gene include enzyme binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for PAWR Gene

  • Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Gene Wiki entry for PAWR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAWR Gene

Genomics for PAWR Gene

Regulatory Elements for PAWR Gene

Enhancers for PAWR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAWR on UCSC Golden Path with GeneCards custom track

Promoters for PAWR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAWR on UCSC Golden Path with GeneCards custom track

Genomic Location for PAWR Gene

Chromosome:
12
Start:
79,574,979 bp from pter
End:
79,691,097 bp from pter
Size:
116,119 bases
Orientation:
Minus strand

Genomic View for PAWR Gene

Genes around PAWR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAWR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAWR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAWR Gene

Proteins for PAWR Gene

  • Protein details for PAWR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ0-PAWR_HUMAN
    Recommended name:
    PRKC apoptosis WT1 regulator protein
    Protein Accession:
    Q96IZ0
    Secondary Accessions:
    • O75796
    • Q6FHY9
    • Q8N700

    Protein attributes for PAWR Gene

    Size:
    340 amino acids
    Molecular mass:
    36568 Da
    Quaternary structure:
    • Interacts with WT1, via the C-terminal region. Homooligomer. Interacts also with a wide variety of proteins, such as atypical PKCs, p62, DAPK3 kinase and THAP1. Interacts with actin, AATF, BACE1, SPSB1, SPSB2 AND SPSB4. Component of a ternary complex composed of SQSTM1 and PRKCZ.

    Three dimensional structures from OCA and Proteopedia for PAWR Gene

neXtProt entry for PAWR Gene

Proteomics data for PAWR Gene at MOPED

Post-translational modifications for PAWR Gene

  • Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
  • Ubiquitination at Lys 333
  • Modification sites at PhosphoSitePlus

Other Protein References for PAWR Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAWR (PAR-4)

No data available for DME Specific Peptides for PAWR Gene

Domains & Families for PAWR Gene

Protein Domains for PAWR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAWR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IZ0

UniProtKB/Swiss-Prot:

PAWR_HUMAN :
  • The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
Domain:
  • The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
  • The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity).
genes like me logo Genes that share domains with PAWR: view

No data available for Gene Families for PAWR Gene

Function for PAWR Gene

Molecular function for PAWR Gene

GENATLAS Biochemistry:
PKC apoptosis WT1 regulator,prostate apoptosis reponse par-4,widely expressed
UniProtKB/Swiss-Prot Function:
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
UniProtKB/Swiss-Prot Induction:
By apoptosis.

Gene Ontology (GO) - Molecular Function for PAWR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0008157 protein phosphatase 1 binding IEA --
genes like me logo Genes that share ontologies with PAWR: view
genes like me logo Genes that share phenotypes with PAWR: view

Animal Models for PAWR Gene

MGI Knock Outs for PAWR:

Animal Model Products

miRNA for PAWR Gene

miRTarBase miRNAs that target PAWR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAWR Gene

Localization for PAWR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAWR Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAWR Gene COMPARTMENTS Subcellular localization image for PAWR gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PAWR Gene

Pathways & Interactions for PAWR Gene

genes like me logo Genes that share pathways with PAWR: view

Pathways by source for PAWR Gene

Gene Ontology (GO) - Biological Process for PAWR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8943350
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA,ISS --
GO:0009611 response to wounding IEA --
GO:0030889 negative regulation of B cell proliferation IEA --
genes like me logo Genes that share ontologies with PAWR: view

No data available for SIGNOR curated interactions for PAWR Gene

Drugs & Compounds for PAWR Gene

(5) Drugs for PAWR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for PAWR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAWR: view

Transcripts for PAWR Gene

Unigene Clusters for PAWR Gene

PRKC, apoptosis, WT1, regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAWR Gene

No ASD Table

Relevant External Links for PAWR Gene

GeneLoc Exon Structure for
PAWR
ECgene alternative splicing isoforms for
PAWR

Expression for PAWR Gene

mRNA expression in normal human tissues for PAWR Gene

Protein differential expression in normal tissues from HIPED for PAWR Gene

This gene is overexpressed in Amniocyte (13.5), Bone marrow stromal cell (13.0), and Prostate (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAWR Gene



SOURCE GeneReport for Unigene cluster for PAWR Gene Hs.643130

mRNA Expression by UniProt/SwissProt for PAWR Gene

Q96IZ0-PAWR_HUMAN
Tissue specificity: Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
genes like me logo Genes that share expression patterns with PAWR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PAWR Gene

Orthologs for PAWR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAWR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAWR 35
  • 87.04 (n)
  • 88.1 (a)
PAWR 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAWR 35
  • 90.78 (n)
  • 92.91 (a)
PAWR 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pawr 35
  • 80.62 (n)
  • 76.81 (a)
Pawr 16
Pawr 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAWR 35
  • 99.41 (n)
  • 98.82 (a)
PAWR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pawr 35
  • 79.25 (n)
  • 76.13 (a)
oppossum
(Monodelphis domestica)
Mammalia PAWR 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAWR 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAWR 35
  • 74.51 (n)
  • 70.59 (a)
PAWR 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAWR 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pawr 35
  • 67.16 (n)
  • 68.14 (a)
zebrafish
(Danio rerio)
Actinopterygii pawr 35
  • 59.26 (n)
  • 62.78 (a)
pawr 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3107 35
Species with no ortholog for PAWR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAWR Gene

ENSEMBL:
Gene Tree for PAWR (if available)
TreeFam:
Gene Tree for PAWR (if available)

Paralogs for PAWR Gene

genes like me logo Genes that share paralogs with PAWR: view

No data available for Paralogs for PAWR Gene

Variants for PAWR Gene

Sequence variations from dbSNP and Humsavar for PAWR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs8176804 - 79,690,120(-) ccccc(C/T)gggAG nc-transcript-variant, reference, missense
rs8176805 - 79,690,012(-) CGCGC(C/G)GGCCG nc-transcript-variant, reference, missense
VAR_022467 -
rs8176870 - 79,621,119(-) GAATG(A/C)AGCTG reference, missense
rs2030899 -- 79,650,147(+) AATTT(C/G)CATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAWR Gene

Variant ID Type Subtype PubMed ID
esv271515 CNV Insertion 20981092

Variation tolerance for PAWR Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAWR Gene

Human Gene Mutation Database (HGMD)
PAWR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAWR Gene

Disorders for PAWR Gene

MalaCards: The human disease database

(3) MalaCards diseases for PAWR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
wilms tumor susceptibility-5
  • wilms tumor
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search PAWR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAWR

Genetic Association Database (GAD)
PAWR
Human Genome Epidemiology (HuGE) Navigator
PAWR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAWR
genes like me logo Genes that share disorders with PAWR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAWR Gene

Publications for PAWR Gene

  1. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. (PMID: 8943350) Johnstone R.W. … Shi Y. (Mol. Cell. Biol. 1996) 2 3 4 23 67
  2. Mapping of the human PAWR (par-4) gene to chromosome 12q21. (PMID: 9790775) Johnstone R.W. … Shi Y. (Genomics 1998) 2 3 23
  3. Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells. (PMID: 20127709) Lee T.J. … Kwon T.K. (J. Cell. Biochem. 2010) 3 23
  4. The Ras effector RASSF2 controls the PAR-4 tumor suppressor. (PMID: 20368356) Donninger H. … Clark G.J. (Mol. Cell. Biol. 2010) 3 23
  5. Down-regulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer. (PMID: 20514395) Nagai M.A. … Soares F.A. (Int. J. Oncol. 2010) 3 23

Products for PAWR Gene

Sources for PAWR Gene

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