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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PATZ1 Gene

protein-coding GIFtS: 53
GCID: GC22M031721

POZ (BTB) and AT hook containing zinc finger 1

(Previous name: zinc finger protein 278 )
(Previous symbol: ZNF278)

Explore 20 diseases affiliated with
PATZ1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
POZ (BTB) And AT Hook Containing Zinc Finger 1¹ ²		Protein Kinase A RI Subunit Alpha-Associated Protein² ³
PATZ¹ ² ³ ⁵		Zinc Finger And BTB Domain-Containing Protein 19² ³
ZNF278¹ ² ³ ⁵		Zinc Finger Sarcoma Gene Protein² ³
Zinc Finger Protein 278¹ ² ³		BTB/POZ Domain Zinc Finger Transcription Factor² ³
RIAZ¹ ² ³		BTB-POZ Domain Zinc Finger Transcription Factor²
ZBTB19¹ ² ³		MAZ-Related Factor²
ZSG¹ ² ³		POZ-, AT Hook-, And Zinc Finger-Containing Protein 1²
MAZR¹ ² ⁵		POZ-AT Hook-Zinc Finger Protein²
DJ400N23¹

External Ids:	HGNC: 13071¹	Entrez Gene: 23598²	Ensembl: ENSG00000100105⁷	OMIM: 605165⁵	UniProtKB: Q9HBE1³

Export aliases for PATZ1 gene to outside databases

Previous GC identifers: GC22M030051 GC22M014683

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PATZ1:

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding

structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to

function as a site for protein-protein interaction and is required for transcriptional repression, and the

zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription

factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS

by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of

chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the

transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an

intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for

this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1

Function: Transcriptional repressor

Gene Wiki entry for PATZ1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PATZ1 gene promoter:
E2F-4 E2F-3a STAT5B E2F-5 Pax-2a E2F-2 c-Ets-1 E2F E2F-1 CP2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PATZ1 promoter sequence

Search SABiosciences Chromatin IP Primers for PATZ1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PATZ1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

PATZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PATZ1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M031721: view genomic region (about GC identifiers)

Start:	31,721,790 bp from pter	End:	31,742,249 bp from pter
Size:	20,460 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1 (See protein sequence)

Recommended Name: POZ-, AT hook-, and zinc finger-containing protein 1

Size: 687 amino acids; 74060 Da

Subcellular location: Nucleus

Sequence caution: Sequence=CAB51404.1; Type=Erroneous initiation;

5 PDB 3D structures from and Proteopedia for PATZ1:

2EPP (3D)

2EPQ (3D)

2EPR (3D)

2EPS (3D)

2YT9 (3D)

Secondary accessions: Q9HBE2 Q9HBE3 Q9P1A9 Q9UDU0 Q9Y529

Alternative splicing: 4 isoforms: Q9HBE1-1 Q9HBE1-2 Q9HBE1-3 Q9HBE1-4

Explore the universe of human proteins at neXtProt for PATZ1: NX_Q9HBE1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBE1

PATZ1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_055138.2 NP_114439.1 NP_114440.1 NP_114441.1

ENSEMBL proteins:

ENSP00000266269 ENSP00000384173 ENSP00000337520 ENSP00000215919

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PATZ1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	10713105

PATZ1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PATZ1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PATZ1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR017956 AT_hook_DNA-bd_motif

IPR000637 HMGI/Y_DNA-bd_CS

IPR000210 BTB/POZ-like

IPR015880 Znf_C2H2-like

IPR011333 BTB/POZ_fold

Graphical View of Domain Structure for InterPro Entry Q9HBE1

ProtoNet protein and cluster: Q9HBE1

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB000515 Binding-protein-dependent transport systems inner membrane component

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 1 A.T hook DNA-binding domain

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 7 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1

Function: Transcriptional repressor

		10/305 SABiosciences Target genes for PATZ1 (see all 305):
		ABCD1 ABHD14A ABHD14B ABHD8 ABTB2 ACACB ACADS ACAT2 ACP2 ADAMTS7

miRNA Products:		OriGene 3'-UTR Clone (see all 4): PATZ1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PATZ1
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PATZ1 (see all 36):
		hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-134 hsa-miR-138-2* hsa-miR-374c hsa-miR-1276 hsa-miR-3622b-3p hsa-miR-3908

		SwitchGear 3'UTR luciferase reporter plasmid: PATZ1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PATZ1 (see all 7) OriGene shRNA RFP: PATZ1 OriGene siRNA: PATZ1
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector (see all 4): PATZ1 (NM_032050)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATZ1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PATZ1
		Search LifeMap BioReagents cell lines for PATZ1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATZ1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	10949935
GO:0003682	chromatin binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--

PATZ1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PATZ1:

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for PATZ1: Patz1^tm1.1Welm Patz1^tm1Pchi
10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Patz1):

cardiovascular system	cellular	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	immune system	mortality/aging	nervous system	reproductive system

PATZ1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Coregulation of Androgen receptor activity

Coregulation of Androgen receptor activity

1.00

Androgen receptor signaling pathway

Androgen receptor signaling pathway

1.00

2 BioSystems Pathways for PATZ1

	Androgen receptor signaling pathway
	Coregulation of Androgen receptor activity

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PATZ1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/10 Interacting proteins for PATZ1 (Q9HBE1^{2, 3} ENSP00000266269⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BACH1	O14867³, ENSP00000286800⁴	I2D: score=2 STRING: ENSP00000286800
MITF	O75030³, ENSP00000295600⁴	I2D: score=2 STRING: ENSP00000295600
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822
RNF4	P78317³, ENSP00000315212⁴	I2D: score=4 STRING: ENSP00000315212
BACH2	Q9BYV9³, ENSP00000257749⁴	I2D: score=2 STRING: ENSP00000257749

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	10713105
GO:0007283	spermatogenesis	IEA	--
GO:0008584	male gonad development	IEA	--
GO:0010468	regulation of gene expression	--	--

PATZ1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PATZ1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PATZ1
2 Novoseek chemical compound relationships for PATZ1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	70.4	36	8449497 (3), 1740334 (2), 18401526 (2), 1981055 (1) (see all 28)
oligonucleotide	23	1	11426589 (1)

Search CenterWatch for drugs/clinical trials and news about PATZ1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PATZ1 gene (4 alternative transcripts):

NM_014323.2 NM_032050.1 NM_032051.1 NM_032052.1

Unigene Cluster for PATZ1:

POZ (BTB) and AT hook containing zinc finger 1

Hs.731398 [show with all ESTs]

Unigene Representative Sequence: NM_014323

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000266269(uc003akp.3 uc003akq.3 uc003akr.3) ENST00000405309

ENST00000351933 ENST00000494109 ENST00000215919(uc003aks.3) ENST00000465287

miRNA Products:		OriGene 3'-UTR Clone (see all 4): PATZ1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PATZ1
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PATZ1 (see all 36):
		hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-134 hsa-miR-138-2* hsa-miR-374c hsa-miR-1276 hsa-miR-3622b-3p hsa-miR-3908

		SwitchGear 3'UTR luciferase reporter plasmid: PATZ1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PATZ1 (see all 7) OriGene shRNA RFP: PATZ1 OriGene siRNA: PATZ1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PATZ1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PATZ1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PATZ1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): PATZ1 (NM_032050)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PATZ1
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PATZ1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PATZ1

Additional cDNA sequence:

AB208787.1 AF119256.1 AF254082.1 AF254083.1 AF254084.1 AF254085.1 AK123441.2 AK291803.1

AL096880.1 AY028384.1 BC021091.1 BC051357.1 CR456613.1

17 DOTS entries:

DT.95165161 DT.100045491 DT.414917 DT.95165152 DT.100782125 DT.101975865 DT.315464 DT.100782130

DT.100687990 DT.100687977 DT.120645552 DT.100696715 DT.102827125 DT.87045977 DT.91672730 DT.95165164

DT.95246274

24/255 AceView cDNA sequences (see all 255):

BM463508 AA953192 BQ687356 BE744394 AI270634 BM729200 AW474585 BU527414

BQ212121 AF254083 AA449718 Z41074 BX409606 AI587571 BM682121 AA287388

AI807017 BM669782 AA813199 AI684278 BE277017 AW083549 BQ574722 AF254084

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PATZ1 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b
SP1:					-		-		-				-		-		-		-
SP2:					-		-		-				-		-		-		-				-
SP3:					-		-		-				-		-		-		-				-		-
SP4:									-				-		-		-		-				-
SP5:					-		-		-				-

ECgene alternative splicing isoforms for PATZ1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PATZ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGCAAGCC

About this image

PATZ1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PATZ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PATZ1

SOURCE GeneReport for Unigene cluster: Hs.731398

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for PATZ1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PATZ1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATZ1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PATZ1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	PATZ1¹	POZ (BTB) and AT hook containing zinc finger 1	81.84(n) 90.9(a)	416963 XM_415256.3 XP_415256.3
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10346²	Transcribed sequence with moderate similarity to protein more	75.15(n)	BX703836.1
zebrafish (Danio rerio)	Actinopterygii	patz1¹	POZ (BTB) and AT hook containing zinc finger 1	63.15(n) 66.67(a)	560290 XM_683687.4 XP_688779.2

ENSEMBL Gene Tree for PATZ1 (if available)
TreeFam Gene Tree for PATZ1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PATZ1 gene

MAZ² VEZF1²

3 SIMAP similar genes for PATZ1 using alignment to 1 protein entry: PATZ1_HUMAN:

ZNF ZNF323 ZNF137P

PATZ1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3788429^1,2	H	--	14685402(+)	`AGCCAA/GTCCTT`	1	--	us2k¹		5		EA NS	1892
rs3788430^1,2	C,H	--	14685652(+)	`ATGCCG/AGGAAG`	1	--	us2k¹ trp³		2		NS EA	300
rs74388335^1,2		--	14686049(+)	`GCAGGG/CCTCTT`	1	--	us2k¹		1		NA	120
rs131207^1,2	C,	--	14686562(+)	`CCCCC-/AACTCC`	1	--	us2k¹		3		NA CSA	10
rs16989519^1,2	C,F,H,	--	14687004(+)	`AGGAAC/TGCCTC`	1	--	nc-transcript-variant		19		NA NS EA WA	2354
rs10567475^1,2	C	--	14687870(+)	`CAGATAAAG/- AAATA`	1	--	ds500¹		1		NA	2
rs5997956^1,2	C,	--	14688059(+)	`CAGAGC/TGAGAC`	1	--	ds500¹		2		NA	4
rs9609261^1,2	C,F,A,H,	--	14704622(+)	`TCTGCA/CCCCGG`	1	--	nc-transcript-variant		11		NS EA NA	1236
rs12160114^1,2		--	14704868(+)	`AAGCCC/TGGAGC`	1	--	nc-transcript-variant		0	--	--	--	--
rs116333934^1,2	C,F,	--	14705003(+)	`TTGTCT/CTCCCA`	1	--	nc-transcript-variant		1		WA	118

HapMap Linkage Disequilibrium report for PATZ1 (31721790 - 31742249 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PATZ1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PATZ1 for disorders About GeneDecksing

OMIM gene information: 605165 OMIM disorders: --

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1

Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation

t(1;22)(p36.1;q12) with EWSR1

20 diseases for PATZ1: About MalaCards

sarcoma soft tissue sarcoma x inactivation lupus erythematosus

b-cell lymphomas systemic lupus erythematosus hearing loss lupus nephritis

nephritis colon carcinoma azoospermia prostate cancer

breast cancer hepatocellular carcinoma prostatitis carcinoma

prostate carcinoma colorectal cancer leukemia neuronitis

5 Novoseek disease relationships for PATZ1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	35.6	1	16115938 (1)
lupus erythematosus systemic	4.9	1	10228048 (1)
prostate cancer	3.73	2	18455330 (1), 11839683 (1)
breast cancer	0	1	10395066 (1)
tumors	0	1	11198926 (1)

Human Genome Epidemiology (HuGE) Navigator: PATZ1 (1 document)

Export disorders for PATZ1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PATZ1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with PATZ1)

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The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I....O'Brien K.P. (1999)
A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. (PubMed id 10713105)^{1, 2, 9} Fedele M....Chiatiotti L. (2000)
Zinc finger protein 278, a potential oncogene in human colorectal cancer. (PubMed id 18401526)^{1, 3, 9} Tian X....Fang J. (2008)
PATZ1 gene has a critical role in the spermatogenesis and testicular tumours. (PubMed id 18241078)^{1, 3} Fedele M....Chieffi P. (2008)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel zinc finger gene is fused to EWS in small round cell tumor. (PubMed id 10949935)^{1, 2} Mastrangelo T.... Sozzi G. (2000)
PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. (PubMed id 11719514)^{1, 9} Pero R....Chiariotti L. (2002)
Interaction of the regulatory subunit of the cAMP-dep endent protein kinase with PATZ1 (ZNF278). (PubMed id 20026299)^{1, 9} Yang W.L....Chin K.V. (2010)
POZ-, AT-hook-, and zinc finger-containing protein (PA TZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for i ts negative autoregulation. (PubMed id 22493480)¹ Pero R....Fedele M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23598	HGNC: 13071	AceView: ZNF278	Ensembl:ENSG00000100105	euGenes: HUgn23598
ECgene: PATZ1	H-InvDB: PATZ1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PATZ1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PATZ1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PATZ1 gene:
Search GeneIP for patents involving PATZ1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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POZ (BTB) and AT hook containing zinc finger 1

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