Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PATZ1 Gene

protein-coding   GIFtS: 55
GCID: GC22M031721

POZ (BTB) And AT Hook Containing Zinc Finger 1

(Previous name: zinc finger protein 278)
(Previous symbol: ZNF278)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
POZ (BTB) And AT Hook Containing Zinc Finger 11 2     ZSG2 3
ZNF2781 2 3 5     BTB/POZ Domain Zinc Finger Transcription Factor2 3
Zinc Finger Protein 2781 2 3     MAZR2 5
PATZ2 3 5     BTB-POZ Domain Zinc Finger Transcription Factor2
Protein Kinase A RI Subunit Alpha-Associated Protein2 3     dJ400N232
Zinc Finger And BTB Domain-Containing Protein 192 3     MAZ-Related Factor2
Zinc Finger Sarcoma Gene Protein2 3     POZ-, AT Hook-, And Zinc Finger-Containing Protein 12
RIAZ2 3     POZ-AT Hook-Zinc Finger Protein2
ZBTB192 3     

External Ids:    HGNC: 130711   Entrez Gene: 235982   Ensembl: ENSG000001001057   OMIM: 6051655   UniProtKB: Q9HBE13   

Export aliases for PATZ1 gene to outside databases

Previous GC identifers: GC22M030051 GC22M014683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PATZ1 Gene:
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding
structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is
thought to function as a site for protein-protein interaction and is required for transcriptional repression, and
the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a
transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this
gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated
(t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating
a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein.
This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced
transcript variants are described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PATZ1 Gene:
PATZ1 (POZ (BTB) and AT hook containing zinc finger 1) is a protein-coding gene. Diseases associated with PATZ1 include sarcoma, and soft tissue sarcoma. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MAZ.

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
Function: Transcriptional repressor

Gene Wiki entry for PATZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the PATZ1 gene promoter:
         E2F-4   E2F-3a   STAT5B   E2F-5   Pax-2a   E2F-2   c-Ets-1   E2F   E2F-1   CP2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPATZ1 promoter sequence
   Search Chromatin IP Primers for PATZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PATZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

PATZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PATZ1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M031721:  view genomic region     (about GC identifiers)

Start:
31,721,790 bp from pter      End:
31,742,249 bp from pter
Size:
20,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1 (See protein sequence)
Recommended Name: POZ-, AT hook-, and zinc finger-containing protein 1  
Size: 687 amino acids; 74060 Da
Sequence caution: Sequence=CAB51404.1; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for PATZ1:
2EPP (3D)        2EPQ (3D)        2EPR (3D)        2EPS (3D)        2YT9 (3D)    
Secondary accessions: Q9HBE2 Q9HBE3 Q9P1A9 Q9UDU0 Q9Y529
Alternative splicing: 4 isoforms:  Q9HBE1-1   Q9HBE1-2   Q9HBE1-3   Q9HBE1-4   

Explore the universe of human proteins at neXtProt for PATZ1: NX_Q9HBE1

Explore proteomics data for PATZ1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys272
  • Modification sites at PhosphoSitePlus

  • See PATZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_055138.2  NP_114439.1  NP_114440.1  NP_114441.1  

    ENSEMBL proteins: 
     ENSP00000266269   ENSP00000384173   ENSP00000337520   ENSP00000215919  

    PATZ1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PATZ1
    OriGene Protein Over-expression Lysate for PATZ1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PATZ1
    GenScript Custom Purified and Recombinant Proteins Services for PATZ1
    Novus Biologicals PATZ1 Proteins
    Novus Biologicals PATZ1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PATZ1

    PATZ1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PATZ1
    OriGene Custom Antibody Services for PATZ1
    Novus Biologicals PATZ1 Antibodies
    Abcam antibodies for PATZ1
    Cloud-Clone Corp. Antibodies for PATZ1
    ThermoFisher Antibody for PATZ1
    LSBio Antibodies in human, mouse, rat for PATZ1

    PATZ1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PATZ1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PATZ1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PATZ1
    Cloud-Clone Corp. CLIAs for PATZ1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 8):
     IPR017956 AT_hook_DNA-bd_motif
     IPR000637 HMGI/Y_DNA-bd_CS
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold

    Graphical View of Domain Structure for InterPro Entry Q9HBE1

    ProtoNet protein and cluster: Q9HBE1

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB000515 Binding-protein-dependent transport systems inner membrane component


    UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 7 C2H2-type zinc fingers


    PATZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PATZ1_HUMAN, Q9HBE1
    Function: Transcriptional repressor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10949935
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    PATZ1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PATZ1:
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Patz1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  immune system  mortality/aging  nervous system  reproductive system 

    PATZ1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PATZ1: Patz1tm1.1Welm Patz1tm1Pchi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PATZ1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PATZ1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PATZ1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PATZ1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for PATZ1 (see all 298):
    ABCD1,  ABHD14A,  ABHD14B,  ABHD8,  ABTB2,  ACACB,  ACADS,  ACAT2,  ACP2,  ADAMTS7

    miRNA
    Products:
        
    miRTarBase miRNAs that target PATZ1:
    hsa-mir-100-5p (MIRT048585)

    Block miRNA regulation of human, mouse, rat PATZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PATZ1 (see all 36):
    hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-134 hsa-miR-138-2* hsa-miR-374c hsa-miR-1276 hsa-miR-3622b-3p hsa-miR-3908
    SwitchGear 3'UTR luciferase reporter plasmidPATZ1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PATZ1
    Predesigned siRNA for gene silencing in human, mouse, rat PATZ1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PATZ1

    Clone
    Products:
         
    OriGene clones in human, mouse for PATZ1 (see all 22)
    OriGene ORF clones in mouse, rat for PATZ1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PATZ1 (NM_032050)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PATZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATZ1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PATZ1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PATZ1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATZ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PATZ1_HUMAN, Q9HBE1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10713105

    PATZ1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PATZ1 About    
    See pathways by source

    SuperPathContained pathways About
    1Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity
    2Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    2 BioSystems Pathways for PATZ1
        Androgen receptor signaling pathway
    Coregulation of Androgen receptor activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PATZ1
    Interactions:

        GeneGlobe Interaction Network for PATZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PATZ1 (Q9HBE12, 3 ENSP000002662694) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BACH1O148673, ENSP000002868004I2D: score=2 STRING: ENSP00000286800
    MITFO750303, ENSP000002956004I2D: score=2 STRING: ENSP00000295600
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    RNF4P783173, ENSP000003152124I2D: score=4 STRING: ENSP00000315212
    BACH2Q9BYV93, ENSP000002577494I2D: score=2 STRING: ENSP00000257749
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS10713105
    GO:0007283spermatogenesis IEA--
    GO:0008584male gonad development IEA--
    GO:0010468regulation of gene expression ----

    PATZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PATZ1

    2 Novoseek inferred chemical compound relationships for PATZ1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 70.4 36 8449497 (3), 1740334 (2), 18401526 (2), 1981055 (1) (see all 28)
    oligonucleotide 23 1 11426589 (1)



    PATZ1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PATZ1 gene (4 alternative transcripts): 
    NM_014323.2  NM_032050.1  NM_032051.1  NM_032052.1  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266269(uc003akp.3 uc003akq.3 uc003akr.3) ENST00000405309
    ENST00000351933 ENST00000494109 ENST00000465287 ENST00000215919(uc003aks.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PATZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PATZ1 (see all 36):
    hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-134 hsa-miR-138-2* hsa-miR-374c hsa-miR-1276 hsa-miR-3622b-3p hsa-miR-3908
    SwitchGear 3'UTR luciferase reporter plasmidPATZ1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PATZ1
    Predesigned siRNA for gene silencing in human, mouse, rat PATZ1
    Clone
    Products:
         
    OriGene clones in human, mouse for PATZ1 (see all 22)
    OriGene ORF clones in mouse, rat for PATZ1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PATZ1 (NM_032050)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PATZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATZ1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PATZ1
    OriGene qSTAR qPCR primer pairs in human, mouse for PATZ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PATZ1
      QuantiTect SYBR Green Assays in human, mouse, rat PATZ1
      QuantiFast Probe-based Assays in human, mouse, rat PATZ1

    Selected AceView cDNA sequences (see all 255):

    BM670946 BF436695 Z41074 NM_032050 BM463508 BQ212121 AV728997 AA928586 
    BQ223974 BM976210 BM669662 AA235073 BM729200 BC051357 AA449718 BM669782 
    AF254082 AI270634 AI342861 BE277017 AA953192 BQ687356 AK123441 BQ002067 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PATZ1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:              -     -     -           -     -     -     -                                 
    SP2:              -     -     -           -     -     -     -           -                     
    SP3:              -     -     -           -     -     -     -           -     -               
    SP4:                          -           -     -     -     -           -                     
    SP5:              -     -     -           -                                                   


    ECgene alternative splicing isoforms for PATZ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PATZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCAAGCC
    PATZ1 Expression
    About this image


    PATZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    PATZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PATZ1 Protein Expression

    UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for PATZ1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PATZ1
    OriGene qSTAR qPCR primer pairs in human, mouse for PATZ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PATZ1
    QuantiTect SYBR Green Assays in human, mouse, rat PATZ1
    QuantiFast Probe-based Assays in human, mouse, rat PATZ1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PATZ1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Patz11 , 5 POZ (BTB) and AT hook containing zinc finger 11, 5 90.8(n)1
    98.91(a)1
      11 (2.30 cM)5
    562181  NM_019574.31  NP_062520.11 
     32888745 
    chicken
    (Gallus gallus)
    Aves PATZ11 POZ (BTB) and AT hook containing zinc finger 1 81.18(n)
    90.18(a)
      416963  XM_004934371.1  XP_004934428.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    10(a)
    many ↔ many
    AAWZ02037404(2979-12230)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.103462 Transcribed sequence with moderate similarity to protein more 75.15(n)    BX703836.1 
    zebrafish
    (Danio rerio)
    Actinopterygii patz11 POZ (BTB) and AT hook containing zinc finger 1 62.2(n)
    65.91(a)
      560290  XM_683687.5  XP_688779.3 


    ENSEMBL Gene Tree for PATZ1 (if available)
    TreeFam Gene Tree for PATZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PATZ1 gene
    MAZ2  VEZF12  
    2 SIMAP similar genes for PATZ1 using alignment to 1 protein entry:     PATZ1_HUMAN:
    ZNF    ZNF323

    PATZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PATZ1 (see all 302)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57535611,2
    C--31721347(+) TCTATA/GAGCCT 3 -- ds50013Minor allele frequency- G:0.25CSA WA EA 240
    rs1508875541,2
    --31721419(+) TGTCAC/TTGTCC 3 -- ds50010--------
    rs1393998851,2
    C--31721530(+) CCACCA/GTATCT 3 -- ds50010--------
    rs744008611,2
    C--31721646(+) CTACCC/TGTCAA 3 -- ds50010--------
    rs412825671,2
    F--31721871(+) CATGTG/AACACA 3 -- ut311Minor allele frequency- A:0.01NA 120
    rs1443997101,2
    --31722083(+) ACTGCA/GGTTTA 3 -- ut310--------
    rs738813711,2
    C--31722160(+) ATAACA/CATAAT 3 -- ut312Minor allele frequency- C:0.07WA 120
    rs59943881,2
    --31722188(+) TAAAAC/TCCAAC 3 -- ut310--------
    rs57492551,2
    C,F,A,H--31722193(+) CCCAAC/TAGCAT 3 -- ut3116Minor allele frequency- T:0.20EA NS NA CSA WA 1996
    rs1926450351,2
    --31722197(+) ACAGCA/GTGTTG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PATZ1 (31721790 - 31742249 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PATZ1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834176CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PATZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for PATZ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605165    OMIM disorders: --

    UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
  • Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation
    t(1;22)(p36.1;q12) with EWSR1

  • 20 diseases for PATZ1:    
    About MalaCards
    sarcoma    soft tissue sarcoma    lupus nephritis    brain cancer
    nephritis    azoospermia    lupus erythematosus    systemic lupus erythematosus
    b-cell lymphomas    prostate cancer    prostatitis    hepatocellular carcinoma
    breast cancer    colorectal cancer    endotheliitis    multiple myeloma
    myeloma    cerebritis    neuronitis    leukemia


    PATZ1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for PATZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 35.6 1 16115938 (1)
    lupus erythematosus systemic 4.9 1 10228048 (1)
    prostate cancer 3.73 2 18455330 (1), 11839683 (1)
    breast cancer 0 1 10395066 (1)
    tumors 0 1 11198926 (1)

    Genetic Association Database (GAD): PATZ1
    Human Genome Epidemiology (HuGE) Navigator: PATZ1 (1 document)

    Export disorders for PATZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PATZ1 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with PATZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. (PubMed id 10713105)1, 2, 9 Fedele M....Chiatiotti L. (J. Biol. Chem. 2000)
    3. Zinc finger protein 278, a potential oncogene in human colorectal cancer. (PubMed id 18401526)1, 3, 9 Tian X....Fang J. (Acta Biochim. Biophys. Sin. (Shanghai) 2008)
    4. [Association of single nucleotide polymorphisms of PATZ1 gene with azoospermia]. (PubMed id 20677143)1, 4 Huang J.X. and A Z.C. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2010)
    5. PATZ1 gene has a critical role in the spermatogenesis and testicular tumours. (PubMed id 18241078)1, 3 Fedele M....Chieffi P. (J. Pathol. 2008)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A novel zinc finger gene is fused to EWS in small round cell tumor. (PubMed id 10949935)1, 2 Mastrangelo T.... Sozzi G. (Oncogene 2000)
    9. PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. (PubMed id 11719514)1, 9 Pero R....Chiariotti L. (J. Biol. Chem. 2002)
    10. Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278). (PubMed id 20026299)1, 9 Yang W.L....Chin K.V. (Biochem. Biophys. Res. Commun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23598 HGNC: 13071 AceView: ZNF278 Ensembl:ENSG00000100105 euGenes: HUgn23598
    ECgene: PATZ1 H-InvDB: PATZ1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PATZ1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PATZ1 gene:
    Search GeneIP for patents involving PATZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PATZ1   OriGene RNAi products in human, mouse, rat for PATZ1  
     OriGene qPCR primer pairs and template standards for PATZ1   OriGene Protein Over-expression Lysate for PATZ1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PATZ1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PATZ1   OriGene Purified Protein for PATZ1  
     OriGene ORF clones in mouse, rat for PATZ1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PATZ1   OriGene Custom Protein Services for PATZ1  

     
     
     Block miRNA regulation of human, mouse, rat PATZ1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PATZ1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PATZ1 Predesigned siRNA for gene silencing in human, mouse, rat PATZ1
     QuantiFast Probe-based Assays in human, mouse, rat PATZ1 QuantiTect SYBR Green Assays in human, mouse, rat PATZ1
     Custom PCR Arrays for PATZ1 Search Chromatin IP Primers for PATZ1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PATZ1  GeneGlobe Interaction Network for PATZ1
     Regulatory tfbs in PATZ1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PATZ1 GenScript cDNA clones with any tag delivered in your preferred vector for PATZ1
     GenScript Custom Assay Services for PATZ1 GenScript Custom overexpressing Cell Line Services for PATZ1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PATZ1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PATZ1 antibodies
     PATZ1 proteins
     PATZ1 lysates
     Antibodies for PATZ1
     See all of Abcam's Antibodies, Kits and Proteins for PATZ1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PATZ1
     Antibodies for PATZ1
     ELISAs for PATZ1
     CLIAs for PATZ1



     Browse ESI BIO Cell Lines and PureStem Progenitors for PATZ1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATZ1
     SwitchGear 3'UTR luciferase reporter plasmids for PATZ1
     SwitchGear Promoter luciferase reporter plasmids for PATZ1
     ThermoFisher Antibody for PATZ1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATZ1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PATZ1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PATZ1
     LSBio Antibodies in human, mouse, rat for PATZ1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PATZ1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4