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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PATZ1 Gene

protein-coding   GIFtS: 57
GCID: GC22M031721

POZ (BTB) And AT Hook Containing Zinc Finger 1

(Previous name: zinc finger protein 278)
(Previous symbol: ZNF278)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
POZ (BTB) And AT Hook Containing Zinc Finger 11 2     ZSG2 3
ZNF2781 2 3 5     BTB/POZ Domain Zinc Finger Transcription Factor2 3
Zinc Finger Protein 2781 2 3     MAZR2 5
PATZ2 3 5     BTB-POZ Domain Zinc Finger Transcription Factor2
Protein Kinase A RI Subunit Alpha-Associated Protein2 3     dJ400N232
Zinc Finger And BTB Domain-Containing Protein 192 3     MAZ-Related Factor2
Zinc Finger Sarcoma Gene Protein2 3     POZ-, AT Hook-, And Zinc Finger-Containing Protein 12
RIAZ2 3     POZ-AT Hook-Zinc Finger Protein2
ZBTB192 3     

External Ids:    HGNC: 130711   Entrez Gene: 235982   Ensembl: ENSG000001001057   OMIM: 6051655   UniProtKB: Q9HBE13   

Export aliases for PATZ1 gene to outside databases

Previous GC identifers: GC22M030051 GC22M014683


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PATZ1 Gene:
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding
structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is
thought to function as a site for protein-protein interaction and is required for transcriptional repression, and
the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a
transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this
gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated
(t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating
a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein.
This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced
transcript variants are described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PATZ1 Gene: 
PATZ1 (POZ (BTB) and AT hook containing zinc finger 1) is a protein-coding gene. Diseases associated with PATZ1 include sarcoma, and soft tissue sarcoma. GO annotations related to this gene include chromatin binding and DNA binding. An important paralog of this gene is MAZ.

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
Function: Transcriptional repressor

Gene Wiki entry for PATZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PATZ1 gene promoter:
         E2F-4   E2F-3a   STAT5B   E2F-5   Pax-2a   E2F-2   c-Ets-1   E2F   E2F-1   CP2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPATZ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PATZ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PATZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

PATZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PATZ1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M031721:  view genomic region     (about GC identifiers)

Start:
31,721,790 bp from pter      End:
31,742,249 bp from pter
Size:
20,460 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1 (See protein sequence)
Recommended Name: POZ-, AT hook-, and zinc finger-containing protein 1  
Size: 687 amino acids; 74060 Da
Subcellular location: Nucleus
Sequence caution: Sequence=CAB51404.1; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for PATZ1:
2EPP (3D)        2EPQ (3D)        2EPR (3D)        2EPS (3D)        2YT9 (3D)    
Secondary accessions: Q9HBE2 Q9HBE3 Q9P1A9 Q9UDU0 Q9Y529
Alternative splicing: 4 isoforms:  Q9HBE1-1   Q9HBE1-2   Q9HBE1-3   Q9HBE1-4   

Explore the universe of human proteins at neXtProt for PATZ1: NX_Q9HBE1

Explore proteomics data for PATZ1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HBE1

  • PATZ1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PATZ1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_055138.2  NP_114439.1  NP_114440.1  NP_114441.1  

    ENSEMBL proteins: 
     ENSP00000266269   ENSP00000384173   ENSP00000337520   ENSP00000215919  

    Human Recombinant Protein Products for PATZ1: 
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    Novus Biologicals PATZ1 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for PATZ1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10713105

    PATZ1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/8 InterPro protein domains (see all 8):
     IPR017956 AT_hook_DNA-bd_motif
     IPR000637 HMGI/Y_DNA-bd_CS
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold

    Graphical View of Domain Structure for InterPro Entry Q9HBE1

    ProtoNet protein and cluster: Q9HBE1

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB000515 Binding-protein-dependent transport systems inner membrane component


    UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 7 C2H2-type zinc fingers


    PATZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PATZ1_HUMAN, Q9HBE1
    Function: Transcriptional repressor

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10949935
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    PATZ1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PATZ1:
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Patz1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  immune system  mortality/aging  nervous system  reproductive system 

    PATZ1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PATZ1: Patz1tm1.1Welm Patz1tm1Pchi

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PATZ1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PATZ1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PATZ1 

    10/302 SABiosciences Target genes for PATZ1 (see all 302):
    ABCD1 ABHD14A ABHD14B ABHD8 ABTB2 ACACB ACADS ACAT2 ACP2 ADAMTS7

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPATZ1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATZ1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PATZ1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity
    2Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    2 BioSystems Pathways for PATZ1
        Androgen receptor signaling pathway
    Coregulation of Androgen receptor activity


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PATZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/10 Interacting proteins for PATZ1 (Q9HBE12, 3 ENSP000002662694) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BACH1O148673, ENSP000002868004I2D: score=2 STRING: ENSP00000286800
    MITFO750303, ENSP000002956004I2D: score=2 STRING: ENSP00000295600
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    RNF4P783173, ENSP000003152124I2D: score=4 STRING: ENSP00000315212
    BACH2Q9BYV93, ENSP000002577494I2D: score=2 STRING: ENSP00000257749
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS10713105
    GO:0007283spermatogenesis IEA--
    GO:0008584male gonad development IEA--
    GO:0010468regulation of gene expression ----

    PATZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PATZ1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PATZ1

    2 Novoseek inferred chemical compound relationships for PATZ1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 70.4 36 8449497 (3), 1740334 (2), 18401526 (2), 1981055 (1) (see all 28)
    oligonucleotide 23 1 11426589 (1)

    Search CenterWatch for drugs/clinical trials and news about PATZ1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PATZ1 gene (4 alternative transcripts): 
    NM_014323.2  NM_032050.1  NM_032051.1  NM_032052.1  

    Unigene Cluster for PATZ1:

    POZ (BTB) and AT hook containing zinc finger 1
    Hs.731398  [show with all ESTs]
    Unigene Representative Sequence: NM_014323
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266269(uc003akp.3 uc003akq.3 uc003akr.3) ENST00000405309
    ENST00000351933 ENST00000494109 ENST00000465287 ENST00000215919(uc003aks.3)

    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PATZ1 (see all 36):
    hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-134 hsa-miR-138-2* hsa-miR-374c hsa-miR-1276 hsa-miR-3622b-3p hsa-miR-3908
    SwitchGear 3'UTR luciferase reporter plasmidPATZ1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB208787.1 AF119256.1 AF254082.1 AF254083.1 AF254084.1 AF254085.1 AK123441.2 AK291803.1 
    AL096880.1 AY028384.1 BC021091.1 BC051357.1 CR456613.1 

    17 DOTS entries:

    DT.95165161  DT.100045491  DT.414917  DT.95165152  DT.100782125  DT.101975865  DT.315464  DT.100782130 
    DT.100687990  DT.100687977  DT.120645552  DT.100696715  DT.102827125  DT.87045977  DT.91672730  DT.95165164 
    DT.95246274 

    24/255 AceView cDNA sequences (see all 255):

    BQ953327 BM463508 R75606 CR456613 AF254085 AW083549 BC021091 AF242522 
    BM693885 CB114052 BQ687356 BX108066 BU631086 AF254083 AI587571 BM670946 
    AF254084 BF530716 BM698876 NM_014323 AI807017 AI291756 BQ636113 NM_032052 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PATZ1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:              -     -     -           -     -     -     -                                 
    SP2:              -     -     -           -     -     -     -           -                     
    SP3:              -     -     -           -     -     -     -           -     -               
    SP4:                          -           -     -     -     -           -                     
    SP5:              -     -     -           -                                                   


    ECgene alternative splicing isoforms for PATZ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PATZ1 expression in normal human tissues (normalized intensities)      PATZ1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCAAGCC
    PATZ1 Expression
    About this image


    PATZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Eye (Sensory Organs)
             Retina

    See PATZ1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PATZ1

    SOURCE GeneReport for Unigene cluster: Hs.731398

    UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PATZ1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Patz11 , 5 POZ (BTB) and AT hook containing zinc finger 11, 5 90.8(n)1
    98.91(a)1
      11 (2.30 cM)5
    562181  NM_019574.31  NP_062520.11 
     32888745 
    chicken
    (Gallus gallus)
    Aves PATZ11 POZ (BTB) and AT hook containing zinc finger 1 81.84(n)
    90.9(a)
      416963  XM_415256.3  XP_415256.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    9(a)
    possible ortholog
    AAWZ02037404(2979-12230)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.103462 Transcribed sequence with moderate similarity to protein more 75.15(n)    BX703836.1 
    zebrafish
    (Danio rerio)
    Actinopterygii patz11 POZ (BTB) and AT hook containing zinc finger 1 63.15(n)
    66.67(a)
      560290  XM_683687.4  XP_688779.2 


    ENSEMBL Gene Tree for PATZ1 (if available)
    TreeFam Gene Tree for PATZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PATZ1 gene
    MAZ2  VEZF12  
    2 SIMAP similar genes for PATZ1 using alignment to 1 protein entry:     PATZ1_HUMAN:
    ZNF    ZNF323

    PATZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 SNPs in PATZ1 are shown (see all 302)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57535611,2
    C--31721347(+) TCTATA/GAGCCT 3 -- ds50013Minor allele frequency- G:0.25CSA WA EA 240
    rs1508875541,2
    --31721419(+) TGTCAC/TTGTCC 3 -- ds50010--------
    rs1393998851,2
    C--31721530(+) CCACCA/GTATCT 3 -- ds50010--------
    rs744008611,2
    C--31721646(+) CTACCC/TGTCAA 3 -- ds50010--------
    rs412825671,2
    F--31721871(+) CATGTG/AACACA 3 -- ut311Minor allele frequency- A:0.01NA 120
    rs1443997101,2
    --31722083(+) ACTGCA/GGTTTA 3 -- ut310--------
    rs738813711,2
    C--31722160(+) ATAACA/CATAAT 3 -- ut312Minor allele frequency- C:0.07WA 120
    rs59943881,2
    --31722188(+) TAAAAC/TCCAAC 3 -- ut310--------
    rs57492551,2
    C,F,A,H--31722193(+) CCCAAC/TAGCAT 3 -- ut3116Minor allele frequency- T:0.20EA NS NA CSA WA 1996
    rs1926450351,2
    --31722197(+) ACAGCA/GTGTTG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PATZ1 (31721790 - 31742249 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PATZ1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834176CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PATZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for PATZ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605165    OMIM disorders: --

    UniProtKB/Swiss-Prot: PATZ1_HUMAN, Q9HBE1
  • Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation
    t(1;22)(p36.1;q12) with EWSR1

  • 16 diseases for PATZ1:    About MalaCards
    sarcoma    soft tissue sarcoma    lupus nephritis    nephritis
    azoospermia    lupus erythematosus    systemic lupus erythematosus    b-cell lymphomas
    prostate cancer    prostatitis    hepatocellular carcinoma    colorectal cancer
    breast cancer    endotheliitis    leukemia    neuronitis


    PATZ1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for PATZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 35.6 1 16115938 (1)
    lupus erythematosus systemic 4.9 1 10228048 (1)
    prostate cancer 3.73 2 18455330 (1), 11839683 (1)
    breast cancer 0 1 10395066 (1)
    tumors 0 1 11198926 (1)

    Genetic Association Database (GAD): PATZ1
    Human Genome Epidemiology (HuGE) Navigator: PATZ1 (1 document)

    Export disorders for PATZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PATZ1 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with PATZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. (PubMed id 10713105)1, 2, 9 Fedele M....Chiatiotti L. (2000)
    3. Zinc finger protein 278, a potential oncogene in human colorectal cancer. (PubMed id 18401526)1, 3, 9 Tian X....Fang J. (2008)
    4. [Association of single nucleotide polymorphisms of PA TZ1 gene with azoospermia]. (PubMed id 20677143)1, 4 Huang J.X. and A Z.C. (2010)
    5. PATZ1 gene has a critical role in the spermatogenesis and testicular tumours. (PubMed id 18241078)1, 3 Fedele M....Chieffi P. (2008)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A novel zinc finger gene is fused to EWS in small round cell tumor. (PubMed id 10949935)1, 2 Mastrangelo T.... Sozzi G. (2000)
    9. PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. (PubMed id 11719514)1, 9 Pero R....Chiariotti L. (2002)
    10. Interaction of the regulatory subunit of the cAMP-dep endent protein kinase with PATZ1 (ZNF278). (PubMed id 20026299)1, 9 Yang W.L....Chin K.V. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23598 HGNC: 13071 AceView: ZNF278 Ensembl:ENSG00000100105 euGenes: HUgn23598
    ECgene: PATZ1 H-InvDB: PATZ1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PATZ1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PATZ1 gene:
    Search GeneIP for patents involving PATZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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