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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PATL1 Gene

protein-coding   GIFtS: 50
GCID: GC11M059404

Protein Associated With Topoisomerase II Homolog 1 (Yeast)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Associated With Topoisomerase II Homolog 1 (Yeast)1 2
Protein PAT1 Homolog B2 3
Pat1b2 3
hPat1b2 3
PAT1-Like Protein 12 3
Protein PAT1 Homolog 12

External Ids:    HGNC: 267211   Entrez Gene: 2199882   Ensembl: ENSG000001668897   OMIM: 6146605   UniProtKB: Q86TB93   

Export aliases for PATL1 gene to outside databases

Previous GC identifers: GC11M059161 GC11M055751


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PATL1 Gene: 
PATL1 (protein associated with topoisomerase II homolog 1 (yeast)) is a protein-coding gene. Diseases associated with PATL1 include hepatitis c, and hepatitis, and among its related super-pathways are Deadenylation-dependent mRNA decay and Metabolism of RNA. GO annotations related to this gene include RNA binding and poly(G) RNA binding. An important paralog of this gene is PATL2.

UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9
Function: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation
of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for
cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and
replication of hepatitis C virus (HCV)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PATL1 gene promoter:
         HFH-3   Max1   HOXA9   HOXA9B   POU3F1   Arnt   Meis-1b   FOXI1   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPATL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PATL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PATL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

PATL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PATL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M059404:  view genomic region     (about GC identifiers)

Start:
59,404,189 bp from pter      End:
59,436,511 bp from pter
Size:
32,323 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9 (See protein sequence)
Recommended Name: Protein PAT1 homolog 1  
Size: 770 amino acids; 86850 Da
Subunit: Interacts (via region A) with DDX6/RCK. Interacts (via region H and region C) with LSM1 and LSM4.
Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1. Interacts with the CCR4-NOT complex. Interacts
with the Lsm-containing SMN-Sm protein complex
Subcellular location: Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly
cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing
speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus
Sequence caution: Sequence=CAD89916.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for PATL1:
2XEQ (3D)        2XER (3D)        2XES (3D)    
Secondary accessions: B3KXT9 Q2TA86 Q6P166 Q8N9M6 Q8NI63
Alternative splicing: 4 isoforms:  Q86TB9-1   Q86TB9-2   Q86TB9-3   Q86TB9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PATL1: NX_Q86TB9

Explore proteomics data for PATL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TB9

  • PATL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PATL1 Protein Expression
    REFSEQ proteins: NP_689929.2  
    ENSEMBL proteins: 
     ENSP00000300146  
    Reactome Protein details: Q86TB9
    Human Recombinant Protein Products for PATL1: 
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    Novus Biologicals PATL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PATL1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005829cytosol TAS--
    GO:0016605PML body IEA--
    GO:0016607nuclear speck IEA--
    GO:0030014colocalizes with CCR4-NOT complex IDA--

    PATL1 for ontologies           About GeneDecksing



    PATL1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019167 Topo_II-assoc_PAT1

    Graphical View of Domain Structure for InterPro Entry Q86TB9

    ProtoNet protein and cluster: Q86TB9

    UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9
    Domain: The region A, also named N-term, mediates the interaction with DDX6/RCK and is required for cytoplasmic
    mRNA processing body assembly
    Domain: The region C, also named Pat-C, is required for RNA-binding and mediates the binding with the
    Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix,
    exposing conserved and basic residues on one side of the domain
    Similarity: Belongs to the PAT1 family


    PATL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PATL1_HUMAN, Q86TB9
    Function: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation
    of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for
    cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and
    replication of hepatitis C virus (HCV)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA--
    GO:0005515protein binding IPI--
    GO:0008266poly(U) RNA binding IDA--
    GO:0034046poly(G) RNA binding IDA--
         
    PATL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PATL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PATL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PATL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PATL1 

    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PATL1 (see all 36):
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    SwitchGear 3'UTR luciferase reporter plasmidPATL1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PATL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    mRNA Decay by 5' to 3' Exoribonuclease0.31
    RNA degradation0.49
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for PATL1
        Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression
    mRNA Decay by 5' to 3' Exoribonuclease


    1         Kegg Pathway  (Kegg details for PATL1):
        RNA degradation


    PATL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PATL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for PATL1 (Q86TB93 ENSP000003001464) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC5O004713I2D: score=4 
    KBTBD7Q8WVZ93I2D: score=1 
    DCP2ENSP000003737154STRING: ENSP00000373715
    DDX6ENSP000002640184STRING: ENSP00000264018
    EDC3ENSP000003205034STRING: ENSP00000320503
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IDA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    PATL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PATL1

    Search CenterWatch for drugs/clinical trials and news about PATL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PATL1 gene: 
    NM_152716.2  

    Unigene Cluster for PATL1:

    Protein associated with topoisomerase II homolog 1 (yeast)
    Hs.591960  [show with all ESTs]
    Unigene Representative Sequence: NM_152716
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300146(uc001noe.4 uc009yms.1) ENST00000531919
    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PATL1 (see all 36):
    hsa-miR-136 hsa-miR-300 hsa-miR-298 hsa-miR-3613-3p hsa-miR-34b hsa-miR-3163 hsa-miR-381 hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidPATL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PATL1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PATL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATL1
    Sirion Biotech Customized lentivirus for stable overexpression of PATL1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PATL1

    Additional mRNA sequence: 

    AB065087.1 AK094193.1 AK127649.1 AK127943.1 AK293213.1 AL831992.2 BC023255.1 BC048309.1 
    BC065264.1 BC109038.1 BC109039.1 BC111047.1 

    4 DOTS entries:

    DT.212302  DT.100779306  DT.99982546  DT.95276145 

    24/216 AceView cDNA sequences (see all 216):

    AA609954 AI332623 AW468519 BC048309 BF433898 AA765123 BM929899 BM830062 
    AI352401 BE644676 AA911919 BQ937699 AA911920 AI500253 AA406642 CR610274 
    AI302415 AI989624 AK094193 BE466679 AI560964 BX491397 AB065087 AA633160 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PATL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19
    SP1:                                                                                                  -                                             
    SP2:                                            -                                                     -                 -     -                     
    SP3:                                                                                                                                                


    ECgene alternative splicing isoforms for PATL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PATL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTCCTAC
    PATL1 Expression
    About this image


    See PATL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PATL1

    SOURCE GeneReport for Unigene cluster: Hs.591960

    UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PATL1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Patl11 , 5 protein associated with topoisomerase II homolog 1 more1, 5 92.68(n)1
    96.49(a)1
      19 (8.57 cM)5
    2259291  NM_172635.31  NP_766223.21 
     119123995 
    chicken
    (Gallus gallus)
    Aves PATL16
    protein associated with topoisomerase II homolog 1...
    80(a)
    1 ↔ 1
    5(496793-500742)
    lizard
    (Anolis carolinensis)
    Reptilia PATL16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    1(90978972-90993875)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66302 Xenopus laevis transcribed sequence with weak similarity more 75.57(n)    BU911618.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11d042 wufa11d04 80.39(n)   334986  CD592579.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Patr-11 Protein associated with topo II related - 1 42.96(n)
    31.96(a)
      42058  NM_142335.2  NP_650592.1 


    ENSEMBL Gene Tree for PATL1 (if available)
    TreeFam Gene Tree for PATL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PATL1 gene
    PATL22  
    1 SIMAP similar gene for PATL1 using alignment to 1 protein entry:     PATL1_HUMAN:
    PATL2

    PATL1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PATL1
    PGOHUM00000234314 PGOHUM00000236775


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/653 SNPs in PATL1 are shown (see all 653)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869174651,2
    --59403699(+) CTTGAA/GCATTT 1 -- int10--------
    rs605995291,2
    --59403748(+) TAAATA/TCACTA 1 -- int10--------
    rs1918144231,2
    --59403751(+) ATTCAC/TTATAA 1 -- int10--------
    rs1510094661,2
    C--59403796(+) GATGAA/GTTTTG 1 -- int10--------
    rs1409051841,2
    C--59404135(+) ATATGC/TTAGAA 1 -- int10--------
    rs112300301,2
    C,H--59404138(+) TGCTAG/AAAACA 1 -- int16Minor allele frequency- A:0.00NS EA NA 420
    rs764788831,2
    C--59404387(+) ACAACG/AGTAGA 1 -- ut313Minor allele frequency- A:0.10NA EA 242
    rs1501281531,2
    C--59404430(+) GGTGGA/GGCCTG 1 -- ut310--------
    rs1386015681,2
    --59404525(+) GTGCAA/TAATGT 1 -- ut310--------
    rs1842916641,2
    --59404581(+) ACATTA/CGAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PATL1 (59404189 - 59436511 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PATL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2469731CNV Insertion19546169
    nsv832172CNV Loss17160897
    nsv819971CNV Loss19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614660    OMIM disorders: --

    2 diseases for PATL1:    About MalaCards
    hepatitis c    hepatitis


    PATL1 for disorders           About GeneDecksing


    Export disorders for PATL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PATL1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with PATL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of PatL1, a human homolog to yeast P body component Pat1. (PubMed id 17936923)1, 2, 3 Scheller N.... Diez J. (2007)
    2. RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor. (PubMed id 22090346)1, 2 Marnef A.... Standart N. (2012)
    3. The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique. (PubMed id 20852261)1, 2 Totaro A....Achsel T. (2011)
    4. The C-terminal alpha-alpha superhelix of Pat is requi red for mRNA decapping in metazoa. (PubMed id 20543818)1, 2 Braun J.E....Izaurralde E. (2010)
    5. Distinct functions of maternal and somatic Pat1 prote in paralogs. (PubMed id 20826699)1, 2 Marnef A....Standart N. (2010)
    6. Human Pat1b connects deadenylation with mRNA decappin g and controls the assembly of processing bodies. (PubMed id 20584987)1, 2 Ozgur S....Stoecklin G. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Identification of the P-body component PATL1 as a nove l ALG-2-interacting protein by in silico and far-Western screening of proline-ri ch proteins. (PubMed id 22437941)1 Osugi K....Maki M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219988 HGNC: 26721 AceView: FLJ36874 Ensembl:ENSG00000166889 euGenes: HUgn219988
    ECgene: PATL1 Kegg: 219988 H-InvDB: PATL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PATL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PATL1 gene:
    Search GeneIP for patents involving PATL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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