Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PATL1 Gene

protein-coding   GIFtS: 50
GCID: GC11M059404

protein associated with topoisomerase II homolog 1 (yeast)

 Explore 2 diseases affiliated with
PATL1 via our new
 Human Malady Compendium 
Biological research products
for PATL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Protein Associated With Topoisomerase II Homolog 1 (Yeast)1 2     PAT1-Like Protein 12 3
Pat1b1 2 3     FLJ368741
Protein PAT1 Homolog B2 3     Protein PAT1 Homolog 12
HPat1b1     

External Ids:    HGNC: 267211   Entrez Gene: 2199882   Ensembl: ENSG000001668897   OMIM: 6146605   UniProtKB: Q86TB93   

Export aliases for PATL1 gene to outside databases

Previous GC identifers: GC11M059161 GC11M055751


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9
Function: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of
mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA
processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus
(HCV)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PATL1 gene promoter:
         HFH-3   Max1   HOXA9   HOXA9B   POU3F1   Arnt   Meis-1b   FOXI1   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPATL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PATL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PATL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

PATL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PATL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M059404:  view genomic region     (about GC identifiers)

Start:
59,404,189 bp from pter      End:
59,436,511 bp from pter
Size:
32,323 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9 (See protein sequence)
Recommended Name: Protein PAT1 homolog 1  
Size: 770 amino acids; 86850 Da
Subunit: Interacts (via region A) with DDX6/RCK. Interacts (via region H and region C) with LSM1 and LSM4. Interacts
(via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1. Interacts with the CCR4-NOT complex. Interacts with the
Lsm-containing SMN-Sm protein complex
Subcellular location: Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic.
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization
to nuclear foci and speckles requires active transcription. Excluded from the nucleolus
Sequence caution: Sequence=CAD89916.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for PATL1:
2XEQ (3D)        2XER (3D)        2XES (3D)    
Secondary accessions: B3KXT9 Q2TA86 Q6P166 Q8N9M6 Q8NI63
Alternative splicing: 4 isoforms:  Q86TB9-1   Q86TB9-2   Q86TB9-3   Q86TB9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PATL1: NX_Q86TB9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86TB9

  • PATL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689929.2  
    ENSEMBL proteins: 
     ENSP00000300146  
    Reactome Protein details: Q86TB9
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PATL1
    OriGene Custom Protein Services for PATL1 
    GenScript Custom Purified and Recombinant Proteins Services for PATL1
    Novus Biologicals PATL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PATL1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005829cytosol TAS--
    GO:0016605PML body IEA--
    GO:0016607nuclear speck IEA--
    GO:0030014colocalizes with CCR4-NOT complex IDA--


    PATL1 for ontologies           About GeneDecksing



    PATL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PATL1 
    GenScript Custom Superior Antibodies Services for PATL1
    Novus Biologicals PATL1 Antibody
    Search for Antibodies for PATL1 at Abcam  
    Uscn Antibodies for PATL1
    ThermoFisher Antibody for PATL1

    Assay Products for PATL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PATL1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PATL1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PATL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019167 Topo_II-assoc_PAT1

    Graphical View of Domain Structure for InterPro Entry Q86TB9

    ProtoNet protein and cluster: Q86TB9

    UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9
    Domain: The region A, also named N-term, mediates the interaction with DDX6/RCK and is required for cytoplasmic mRNA
    processing body assembly
    Domain: The region C, also named Pat-C, is required for RNA-binding and mediates the binding with the Lsm-containing
    SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and
    basic residues on one side of the domain
    Similarity: Belongs to the PAT1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9
    Function: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of
    mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA
    processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus
    (HCV)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PATL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PATL1
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PATL1 (see all 36):
    hsa-miR-136 hsa-miR-300 hsa-miR-298 hsa-miR-3613-3p hsa-miR-34b hsa-miR-3163 hsa-miR-381 hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidPATL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PATL1 (see all 3)
    OriGene siRNA: PATL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PATL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PATL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PATL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PATL1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PATL1 (NM_152716)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PATL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PATL1
    Search LifeMap BioReagents cell lines for PATL1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATL1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA--
    GO:0005515protein binding IPI--
    GO:0008266poly(U) RNA binding IDA--
    GO:0034046poly(G) RNA binding IDA--


    PATL1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay1.00
    mRNA Decay by 5' to 3' Exoribonuclease0.31
    RNA degradation0.50
    2Metabolism of mRNA
    Metabolism of mRNA1.00
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for PATL1
        Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression
    mRNA Decay by 5' to 3' Exoribonuclease


    1         Kegg Pathway  (Kegg details for PATL1):
        RNA degradation


    PATL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PATL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for PATL1 (Q86TB93 ENSP000003001464) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC5O004713I2D: score=4 
    KBTBD7Q8WVZ93I2D: score=1 
    DCP2ENSP000003737154STRING: ENSP00000373715
    DDX6ENSP000002640184STRING: ENSP00000264018
    EDC3ENSP000003205034STRING: ENSP00000320503
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IDA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--


    PATL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PATL1
    Search CenterWatch for drugs/clinical trials and news about PATL1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PATL1 gene: 
    NM_152716.2  

    Unigene Cluster for PATL1:

    Protein associated with topoisomerase II homolog 1 (yeast)
    Hs.591960  [show with all ESTs]
    Unigene Representative Sequence: NM_152716
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300146(uc001noe.4 uc009yms.1) ENST00000531919 ENST00000529605(uc010rkw.2)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PATL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PATL1
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PATL1 (see all 36):
    hsa-miR-136 hsa-miR-300 hsa-miR-298 hsa-miR-3613-3p hsa-miR-34b hsa-miR-3163 hsa-miR-381 hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidPATL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PATL1 (see all 3)
    OriGene siRNA: PATL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PATL1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PATL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PATL1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PATL1 (NM_152716)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PATL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATL1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PATL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PATL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PATL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PATL1

    Additional cDNA sequence: 

    AB065087.1 AK094193.1 AK127649.1 AK127943.1 AK293213.1 AL831992.2 BC023255.1 BC048309.1 
    BC065264.1 BC109038.1 BC109039.1 BC111047.1 

    4 DOTS entries:

    DT.212302  DT.100779306  DT.99982546  DT.95276145 

    24/216 AceView cDNA sequences (see all 216):

    BQ424500 AI565227 AA227960 BE644676 AA862001 AA843533 BQ440594 AI692780 
    CA421807 AI352401 NM_152716 BM742405 BC023255 BC065264 AA179756 AK127943 
    AA765123 AB065087 AA911920 BM830062 AI479234 AA707195 AI989624 AI473781 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PATL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19
    SP1:                                                                                                  -                                             
    SP2:                                            -                                                     -                 -     -                     
    SP3:                                                                                                                                                


    ECgene alternative splicing isoforms for PATL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PATL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTTCCTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PATL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PATL1

    SOURCE GeneReport for Unigene cluster: Hs.591960

    UniProtKB/Swiss-Prot: PATL1_HUMAN, Q86TB9
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PATL1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PATL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PATL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PATL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PATL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PATL1 gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia PATL16
    --
    80(a)
    1 ↔ 1
    1(90978972-90993875)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66302 Xenopus laevis transcribed sequence with weak similarity more 75.57(n)    BU911618.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11d042 wufa11d04 80.39(n)   334986  CD592579.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Patr-11 Protein associated with topo II related - 1 42.96(n)
    31.96(a)
      42058  NM_142335.2  NP_650592.1 


    ENSEMBL Gene Tree for PATL1 (if available)
    TreeFam Gene Tree for PATL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PATL1 gene
    PATL22  
    1 SIMAP similar gene for PATL1 using alignment to 1 protein entry:     PATL1_HUMAN:
    PATL2

    PATL1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PATL1
    PGOHUM00000234314 PGOHUM00000236775


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/495 NCBI SNPs in PATL1 are shown (see all 495    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869174651,2
    --59403699(+) CTTGAA/GCATTT 1 -- int10--------
    rs605995291,2
    --59403748(+) TAAATA/TCACTA 1 -- int10--------
    rs1918144231,2
    --59403751(+) ATTCAC/TTATAA 1 -- int10--------
    rs1510094661,2
    --59403796(+) GATGAA/GTTTTG 1 -- int10--------
    rs1409051841,2
    --59404135(+) ATATGC/TTAGAA 1 -- int10--------
    rs112300301,2
    C,H--59404138(+) TGCTAG/AAAACA 1 -- int16Minor allele frequency- A:0.00NS EA NA 420
    rs764788831,2
    C,--59404387(+) ACAACG/AGTAGA 1 -- ut313Minor allele frequency- A:0.10NA EA 242
    rs1501281531,2
    --59404430(+) GGTGGA/GGCCTG 1 -- ut310--------
    rs1386015681,2
    --59404525(+) GTGCAA/TAATGT 1 -- ut310--------
    rs1842916641,2
    --59404581(+) ACATTA/CGAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PATL1 (59404189 - 59436511 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for PATL1
         4 CNVs: 4746 85808 58530 101231

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PATL1
    DNA2.0 Custom Variant and Variant Library Synthesis for PATL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PATL1 for disorders           About GeneDecksing

    OMIM gene information: 614660    OMIM disorders: --

    2 diseases for PATL1:    About MalaCards
    hepatitis c    hepatitis


    Export disorders for PATL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PATL1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with PATL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of PatL1, a human homolog to yeast P body component Pat1. (PubMed id 17936923)1, 2, 3 Scheller N.... Diez J. (2007)
    2. RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor. (PubMed id 22090346)1, 2 Marnef A.... Standart N. (2012)
    3. The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique. (PubMed id 20852261)1, 2 Totaro A....Achsel T. (2011)
    4. The C-terminal alpha-alpha superhelix of Pat is requi red for mRNA decapping in metazoa. (PubMed id 20543818)1, 2 Braun J.E....Izaurralde E. (2010)
    5. Distinct functions of maternal and somatic Pat1 prote in paralogs. (PubMed id 20826699)1, 2 Marnef A....Standart N. (2010)
    6. Human Pat1b connects deadenylation with mRNA decappin g and controls the assembly of processing bodies. (PubMed id 20584987)1, 2 Ozgur S....Stoecklin G. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219988 HGNC: 26721 AceView: FLJ36874 Ensembl:ENSG00000166889 euGenes: HUgn219988
    ECgene: PATL1 Kegg: 219988 H-InvDB: PATL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PATL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PATL1 gene:
    Search GeneIP for patents involving PATL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PATL1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PATL1  
     OriGene Protein Over-expression Lysate for PATL1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PATL1   OriGene 3'-UTR Clone for PATL1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PATL1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PATL1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PATL1   OriGene Custom Protein Services for PATL1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PATL1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PATL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PATL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PATL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PATL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PATL1
     GenScript Custom Purified and Recombinant Proteins Services for PATL1 GenScript cDNA clones with any tag delivered in your preferred vector for PATL1
     GenScript Custom Assay Services for PATL1 GenScript Custom Superior Antibodies Services for PATL1
     GenScript Custom overexpressing Cell Line Services for PATL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PATL1 promoter
     Search Chromatin IP Primers for PATL1
     RT2 qPCR Primer Assay in human, mouse, rat PATL1
     Search GNC Networks for PATL1
     SABiosciences Custom PCR Arrays for PATL1
     Search Tocris compounds for PATL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PATL1 antibodies
     PATL1 lysates
     Search for Antibodies for PATL1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PATL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PATL1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PATL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PATL1
     SwitchGear 3'UTR luciferase reporter plasmids for PATL1
     SwitchGear Promoter luciferase reporter plasmids for PATL1
     ThermoFisher Antibody for PATL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PATL1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PATL1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4