Aliases for PATJ Gene
External Ids for PATJ Gene
Previous HGNC Symbols for PATJ Gene
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for PATJ Gene
PATJ (PATJ, Crumbs Cell Polarity Complex Component) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Hippo signaling pathway. An important paralog of this gene is PDZD2.
UniProtKB/Swiss-Prot for PATJ Gene
Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).