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Aliases for PATJ Gene

Aliases for PATJ Gene

  • PATJ, Crumbs Cell Polarity Complex Component 2 3
  • Inactivation-No-Afterpotential D-Like 2 3
  • Protein Associated To Tight Junctions 3 4
  • InaD-Like (Drosophila) 2 5
  • HINADL 3 4
  • INADL 3 5
  • Inactivation No After-Potential D-Like Protein 3
  • PALS1-Associated Tight Junction Protein 3
  • Pals1-Associated Tight Junction Protein 4
  • Channel-Interacting PDZ Domain Protein 3
  • Pals1-Associated Tight Junction 2
  • PDZ Domain Protein 3
  • Inadl Protein 4
  • InaD-Like 3
  • Cipp 3

External Ids for PATJ Gene

Previous HGNC Symbols for PATJ Gene

  • INADL

Summaries for PATJ Gene

Entrez Gene Summary for PATJ Gene

  • This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for PATJ Gene

PATJ (PATJ, Crumbs Cell Polarity Complex Component) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Hippo signaling pathway. An important paralog of this gene is PDZD2.

UniProtKB/Swiss-Prot for PATJ Gene

  • Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).

Gene Wiki entry for PATJ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PATJ Gene

Genomics for PATJ Gene

Regulatory Elements for PATJ Gene

Promoters for PATJ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PATJ on UCSC Golden Path with GeneCards custom track

Genomic Location for PATJ Gene

Chromosome:
1
Start:
61,742,477 bp from pter
End:
62,178,675 bp from pter
Size:
436,199 bases
Orientation:
Plus strand

Genomic View for PATJ Gene

Genes around PATJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PATJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PATJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PATJ Gene

Proteins for PATJ Gene

  • Protein details for PATJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI35-INADL_HUMAN
    Recommended name:
    InaD-like protein
    Protein Accession:
    Q8NI35
    Secondary Accessions:
    • O15249
    • O43742
    • O60833
    • Q5VUA5
    • Q5VUA6
    • Q5VUA7
    • Q5VUA8
    • Q5VUA9
    • Q5VUB0
    • Q8WU78
    • Q9H3N9

    Protein attributes for PATJ Gene

    Size:
    1801 amino acids
    Molecular mass:
    196368 Da
    Quaternary structure:
    • Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, MPP7, HTR2A and SLC6A4 (By similarity). Forms a ternary complex with MPP5, CRB1 and CRB3. Interacts with TJP3/ZO-3 and CLDN1/claudin-1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Directly interacts with HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif). Interacts (via C-terminus) with ARHGEF18 (PubMed:22006950).
    SequenceCaution:
    • Sequence=CAH70416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22258.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PATJ Gene

    Alternative splice isoforms for PATJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PATJ Gene

Proteomics data for PATJ Gene at MOPED

Post-translational modifications for PATJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PATJ Gene

Domains & Families for PATJ Gene

Gene Families for PATJ Gene

Protein Domains for PATJ Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PATJ Gene

Graphical View of Domain Structure for InterPro Entry

Q8NI35

UniProtKB/Swiss-Prot:

INADL_HUMAN :
  • The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions.
Domain:
  • The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions.
  • The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization.
  • Contains 1 L27 domain.
  • Contains 10 PDZ (DHR) domains.
genes like me logo Genes that share domains with PATJ: view

Function for PATJ Gene

Molecular function for PATJ Gene

UniProtKB/Swiss-Prot Function:
Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).
genes like me logo Genes that share phenotypes with PATJ: view

Animal Model Products

miRNA for PATJ Gene

miRTarBase miRNAs that target PATJ

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PATJ Gene

Localization for PATJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PATJ Gene

Cell junction, tight junction. Apical cell membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells (PubMed:22006950). Also found at the apical plasma membrane. {ECO:0000250 UniProtKB:Q63ZW7, ECO:0000269 PubMed:22006950}.

Gene Ontology (GO) - Cellular Components for PATJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016324 apical plasma membrane IEA --
GO:0043234 protein complex IEA --
GO:0045177 apical part of cell IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PATJ: view

No data available for Subcellular locations from COMPARTMENTS for PATJ Gene

Pathways & Interactions for PATJ Gene

genes like me logo Genes that share pathways with PATJ: view

Pathways by source for PATJ Gene

Gene Ontology (GO) - Biological Process for PATJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with PATJ: view

No data available for SIGNOR curated interactions for PATJ Gene

Drugs & Compounds for PATJ Gene

(5) Drugs for PATJ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PATJ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PATJ: view

Transcripts for PATJ Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PATJ Gene

No ASD Table

Relevant External Links for PATJ Gene

GeneLoc Exon Structure for
PATJ
ECgene alternative splicing isoforms for
PATJ

Expression for PATJ Gene

mRNA Expression by UniProt/SwissProt for PATJ Gene

Q8NI35-INADL_HUMAN
Tissue specificity: Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PATJ Gene

Orthologs for PATJ Gene

This gene was present in the common ancestor of animals.

Orthologs for PATJ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INADL 35
  • 88.44 (n)
  • 87.44 (a)
INADL 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inadl 16
Inadl 35
  • 81.87 (n)
  • 81.2 (a)
Inadl 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inadl 35
  • 81.82 (n)
  • 81.2 (a)
chimpanzee
(Pan troglodytes)
Mammalia INADL 35
  • 99.37 (n)
  • 99.16 (a)
INADL 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INADL 35
  • 89.98 (n)
  • 88.57 (a)
INADL 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INADL 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INADL 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves INADL 36
  • 66 (a)
OneToOne
INADL 35
  • 70.03 (n)
  • 68.35 (a)
lizard
(Anolis carolinensis)
Reptilia INADL 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inadl 35
  • 64.71 (n)
  • 62.03 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.20603 35
inadl 36
  • 48 (a)
OneToOne
inadl 35
  • 58.86 (n)
  • 59.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1952 35
fruit fly
(Drosophila melanogaster)
Insecta Patj 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mpz-1 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
CSA.5918 36
  • 30 (a)
OneToMany
Species with no ortholog for PATJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PATJ Gene

ENSEMBL:
Gene Tree for PATJ (if available)
TreeFam:
Gene Tree for PATJ (if available)

Paralogs for PATJ Gene

Paralogs for PATJ Gene

genes like me logo Genes that share paralogs with PATJ: view

Variants for PATJ Gene

Sequence variations from dbSNP and Humsavar for PATJ Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1363 -- 62,052,250(-) AAACC(C/T)GAAAG intron-variant
rs2938 -- 61,865,716(+) GGAAA(C/T)AGACT intron-variant
rs505903 -- 61,781,086(+) ATTGC(C/T)CTAGG intron-variant
rs525523 -- 61,777,477(-) atctc(A/G)gctca intron-variant
rs525526 -- 61,777,472(-) ggctc(A/G)aagca intron-variant

Variation tolerance for PATJ Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.16; 96.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PATJ Gene

HapMap Linkage Disequilibrium report
PATJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PATJ Gene

Disorders for PATJ Gene

Relevant External Links for PATJ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PATJ

No disorders were found for PATJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PATJ Gene

Publications for PATJ Gene

  1. Molecular characterization of a novel PDZ domain protein with homology to INAD from Drosophila melanogaster. (PMID: 9280290) Philipp S. … Flockerzi V. (FEBS Lett. 1997) 2 3 4 23 67
  2. Channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics. (PMID: 19138174) Alpi E. … Dente L. (Biochem. J. 2009) 3 23
  3. PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6. (PMID: 17287269) Storrs C.H. … Silverstein S.J. (J. Virol. 2007) 3 23
  4. The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. (PMID: 11872753) Anzai N. … Lingueglia E. (J. Biol. Chem. 2002) 3 23
  5. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. (PMID: 11927608) Roh M.H. … Margolis B. (J. Cell Biol. 2002) 3 23

Products for PATJ Gene

Sources for PATJ Gene

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