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PASK Gene

protein-coding   GIFtS: 65
GCID: GC02M242045

PAS Domain Containing Serine/Threonine Kinase

  See PASK-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PAS Domain Containing Serine/Threonine Kinase1 2     Per-Arnt-Sim (PAS) Domain Kinase2
PASKIN2 3     EC 2.7.11.13
KIAA01353 5     PAS-kinase3
STK372     hPASK3
PAS Domain-Containing Serine/Threonine-Protein Kinase2     

External Ids:    HGNC: 172701   Entrez Gene: 231782   Ensembl: ENSG000001156877   OMIM: 6075055   UniProtKB: Q96RG23   

Export aliases for PASK gene to outside databases

Previous GC identifers: GC02P239351 GC02P240214 GC02M242065 GC02M242366 GC02M241765 GC02M233801


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PASK Gene:
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this
gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression.
Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for PASK Gene:
PASK (PAS domain containing serine/threonine kinase) is a protein-coding gene. Diseases associated with PASK include glanders. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol binding. An important paralog of this gene is PIM2.

UniProtKB/Swiss-Prot: PASK_HUMAN, Q96RG2
Function: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates
EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose,
nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates
glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved
in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha
cells; however such data require additional evidences. May play a role in regulation of protein translation by
phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory
regulation

Gene Wiki entry for PASK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PASK gene promoter:
         NF-1/L   NF-1   Pax-5   AML1a   CUTL1   AREB6   Egr-2   c-Myb   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPASK promoter sequence
   Search Chromatin IP Primers for PASK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PASK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

PASK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PASK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M242045:  view genomic region     (about GC identifiers)

Start:
242,045,514 bp from pter      End:
242,089,679 bp from pter
Size:
44,166 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PASK_HUMAN, Q96RG2 (See protein sequence)
Recommended Name: PAS domain-containing serine/threonine-protein kinase  
Size: 1323 amino acids; 142929 Da
Sequence caution: Sequence=BAA09484.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for PASK:
1LL8 (3D)        3DLS (3D)    
Secondary accessions: G5E9F1 Q05BE4 Q68DY3 Q6GSJ5 Q86XH6 Q99763 Q9UFR7
Alternative splicing: 3 isoforms:  Q96RG2-1   Q96RG2-2   Q96RG2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PASK: NX_Q96RG2

Explore proteomics data for PASK at MOPED

Post-translational modifications: 

  • Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PASK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001239048.1  NP_001239049.1  NP_001239051.1  NP_001239053.1  NP_055963.2  

    ENSEMBL proteins: 
     ENSP00000234040   ENSP00000384016   ENSP00000351475   ENSP00000384438   ENSP00000408506  
     ENSP00000395672   ENSP00000400734   ENSP00000397922   ENSP00000441374   ENSP00000443083  

    PASK Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PAS domain containing serine/threonine kinase
    PASK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96RG2

    ProtoNet protein and cluster: Q96RG2

    2 Blocks protein domains:
    IPB000014 PAS domain
    IPB013767 PAS fold


    UniProtKB/Swiss-Prot: PASK_HUMAN, Q96RG2
    Domain: The protein kinase domain mediates binding to phosphatidylinositol
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PASK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PASK_HUMAN, Q96RG2
    Function: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates
    EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose,
    nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates
    glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved
    in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha
    cells; however such data require additional evidences. May play a role in regulation of protein translation by
    phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory
    regulation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand
    desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165
    (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report,
    autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation
    is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon
    phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited
    upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate)

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA16275910
    GO:0004713protein tyrosine kinase activity ----
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI16275910
         
    Find genes that share ontologies with PASK           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PASK:
     Decreased substrate adherent c  High actin ratio cells  Increased cell death HMECs cel 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pask):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  liver/biliary system 
     muscle  nervous system  reproductive system  respiratory system 

    Find genes that share phenotypes with PASK           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PASK
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    miRNA
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    hsa-mir-215-5p (MIRT024926), hsa-mir-192-5p (MIRT026483)

    Block miRNA regulation of human, mouse, rat PASK using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PASK:
    hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidPASK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PASK

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PASK_HUMAN, Q96RG2: Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece
    of sperm tails
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus4
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17595531
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with PASK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PASK About    
    See pathways by source

    SuperPathContained pathways About
    1Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with PASK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PASK
        Glucose / Energy Metabolism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PASK
    Interactions:

        GeneGlobe Interaction Network for PASK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PASK (Q96RG21, 2, 3 ENSP000002340404) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHKBQ931001, 2, 3, ENSP000003135044EBI-1042651,EBI-740559 MINT-8145434 MINT-8148568 I2D: score=1 STRING: ENSP00000313504
    EIF4ENIF1Q9NRA82, 3, ENSP000003281034MINT-8145410 I2D: score=1 STRING: ENSP00000328103
    FGAP026712, 3, ENSP000003063614MINT-8149008 I2D: score=1 STRING: ENSP00000306361
    FXNQ165952, 3, ENSP000003664824MINT-8145353 I2D: score=1 STRING: ENSP00000366482
    HSPB1P047922, 3, ENSP000002485534MINT-8148722 I2D: score=1 STRING: ENSP00000248553
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006468protein phosphorylation IDA16275910
    GO:0007165signal transduction ----
    GO:0043576regulation of respiratory gaseous exchange ISS--
    GO:0045719negative regulation of glycogen biosynthetic process IDA16275910

    Find genes that share ontologies with PASK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PASK

    2 HMDB Compounds for PASK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 Novoseek inferred chemical compound relationships for PASK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 23.8 5 9761740 (2)
    oxygen 14.7 4 15148392 (1), 11688972 (1), 15936961 (1)
    glucose 2.39 8 15148392 (3), 17052199 (1)



    Find genes that share compounds with PASK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PASK gene (5 alternative transcripts): 
    NM_001252119.1  NM_001252120.1  NM_001252122.1  NM_001252124.1  NM_015148.3  

    Unigene Cluster for PASK:

    PAS domain containing serine/threonine kinase
    Hs.397891  [show with all ESTs]
    Unigene Representative Sequence: NM_001252124
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234040(uc010zol.2 uc010zom.2 uc002wao.2 uc010fzl.2 uc010zon.2)
    ENST00000472072 ENST00000405260(uc021vzf.1) ENST00000358649 ENST00000489256
    ENST00000475666 ENST00000403638(uc002waq.3) ENST00000493544(uc002wap.3)
    ENST00000459710 ENST00000437780 ENST00000433589 ENST00000415234 ENST00000485940
    ENST00000452907 ENST00000544142 ENST00000539818
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    hsa-miR-129-3p hsa-miR-129*
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PASK
      QuantiFast Probe-based Assays in human, mouse, rat PASK

    Additional mRNA sequence: 

    AF387103.1 AK026769.1 AK056516.1 AK296945.1 AK302417.1 AK302561.1 BC020054.1 BC043495.1 
    BC050565.1 BC063585.1 CR749231.1 D50925.2 U79240.1 

    10 DOTS entries:

    DT.211779  DT.405306  DT.95331006  DT.97792854  DT.100754303  DT.100846196  DT.40116856  DT.95286285 
    DT.95316064  DT.75102265 

    2 AceView cDNA sequences:

    AL117400 AW512692 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PASK (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ·
    SP1:              -     -           -                             -                                               -     -                                       
    SP2:                                                                                                                                                            
    SP3:              -     -           -     -     -     -     -     -                                                                                             
    SP4:                                                                                                                                                            
    SP5:              -     -     -     -     -     -     -     -     -                                                                                             

    ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:                                                                                    
    SP2:                    -                       -     -                                 
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for PASK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PASK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGTCCAG
    PASK Expression
    About this image


    PASK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             T-Cytotoxic Cells Peripheral Blood
    PASK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PASK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.397891

    UniProtKB/Swiss-Prot: PASK_HUMAN, Q96RG2
    Tissue specificity: Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced
    expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein
    level)

        Custom PCR Arrays for PASK
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PASK gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pask1 , 5 PAS domain containing serine/threonine kinase1, 5 76.92(n)1
    73.02(a)1
      1 (47.24 cM)5
    2692241  NM_080850.21  NP_543126.21 
     933087705 
    chicken
    (Gallus gallus)
    Aves PASK6
    PAS domain containing serine/threonine kinase
    41(a)
    1 ↔ 1
    9(4409466-4428357)
    lizard
    (Anolis carolinensis)
    Reptilia PASK6
    PAS domain containing serine/threonine kinase
    48(a)
    1 ↔ 1
    3(30099366-30128193)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.323412 Xenopus laevis transcribed sequence with weak similarity more 76.32(n)    BJ631511.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb69h072 wufb69h07 72.78(n)   322674  AI544962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pask6
    PAS kinase
    31(a)
    1 ↔ 1
    2R(19876240-19879573)
    worm
    (Caenorhabditis elegans)
    Secernentea prk-26
    prk-16
    Protein PRK-2 (prk-2) mRNA, complete cds
    Protein PRK-1, isoform b (prk-1) mRNA, complete cd...
    23(a)
    17(a)
    1 ↔ many
    1 ↔ many
    III(3363228-3370209) WBGene00004183
    III(6990171-7002311) WBGene00004182
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSK1(YAL017W)4 One of two (see also PSK2) PAS domain containing S/T more   --   1(120225-124295) 851216  NP_009385.1 


    ENSEMBL Gene Tree for PASK (if available)
    TreeFam Gene Tree for PASK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PASK gene
    PIM22  PIM12  PIM32  
    Selected SIMAP similar genes for PASK using alignment to 7 protein entries:     PASK_HUMAN (see all proteins) (see all similar genes):
    KIAA0135    NUAK1    MARK3    MARK4    HUNK    BRSK2
    PRKAA1    BRAF    RPS6KA1    STK25    ULK1    CAMK1
    KIN27    MARK2    PHKG1    CHEK1    DAPK1    NEK9

    Find genes that share paralogs with PASK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PASK (see all 1403)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409864
    A metastatic melanoma sample4--see VAR_0409862 E K mis40--------
    rs1112920971,2
    C,F--242045123(+) CAGCTC/TGGAGG 4 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1425012191,2
    C--242045135(+) ATACA-/GGGCTGGAGCCCCTCAC
    ACAGACCAGAGGTGGGGGCT
    GGGCC
    4 -- ds50010--------
    rs1817600791,2
    --242045194(+) ATGTGA/GACAGA 4 -- ds50010--------
    rs1481094581,2
    --242045239(+) CTGCTA/GGCAGT 4 -- ds50010--------
    rs1129433261,2
    C,F--242045512(+) GTCAGG/AATAAC 4 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1506371291,2
    C--242045560(+) TGAGG-/AAATA 
            
    AATTA
    4 -- ut310--------
    rs32751,2
    C,F,H--242045589(+) CCATTT/GGACTA 4 -- ut3111Minor allele frequency- G:0.01MN NS EA NA 1654
    rs168432771,2
    C,F,H--242045631(+) TCAGAT/CGAGCA 4 -- ut3119Minor allele frequency- C:0.08NA NS EA WA 1864
    rs1844709301,2
    --242045649(+) AGTCAA/GAGGAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for PASK (242045514 - 242089679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PASK (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721981CNV Deletion23290073
    esv2721977CNV Deletion23290073
    esv2667460CNV Deletion23128226
    esv2721983CNV Deletion23290073
    esv2721982CNV Deletion23290073
    esv2721976CNV Deletion23290073
    esv1931784CNV Deletion18987734
    esv2721978CNV Deletion23290073
    esv2721985CNV Deletion23290073
    dgv687e201CNV Deletion23290073

    Human Gene Mutation Database (HGMD): PASK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PASK
    DNA2.0 Custom Variant and Variant Library Synthesis for PASK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607505    OMIM disorders: --

    1 disease for PASK:    
    About MalaCards
    glanders

    1 disease from the University of Copenhagen DISEASES database for PASK:
    Glanders

    Find genes that share disorders with PASK           About GenesLikeMe

    Genetic Association Database (GAD): PASK
    Human Genome Epidemiology (HuGE) Navigator: PASK (14 documents)

    Export disorders for PASK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PASK gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with PASK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. (PubMed id 11459942)1, 2, 3 Rutter J.... McKnight S.L. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. (PubMed id 15148392)1, 3, 9 da Silva Xavier G....Rutter G.A. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. (PubMed id 17595531)1, 2, 9 Eckhardt K.... Wenger R.H. (Cell. Physiol. Biochem. 2007)
    4. Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. (PubMed id 11688972)1, 3, 9 Hofer T....Wenger R.H. (Biochem. Biophys. Res. Commun. 2001)
    5. Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. (PubMed id 12377121)1, 2, 9 Amezcua C.A.... Gardner K.H. (Structure 2002)
    6. Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. (PubMed id 21181396)1, 2 da Silva Xavier G.... Rutter G.A. (Diabetologia 2011)
    7. Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. (PubMed id 20943661)1, 2 Kikani C.K.... Rutter J. (J. Biol. Chem. 2010)
    8. Control of mammalian glycogen synthase by PAS kinase. (PubMed id 16275910)1, 2 Wilson W.A....Rutter J. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23178 HGNC: 17270 AceView: PASK Ensembl:ENSG00000115687 euGenes: HUgn23178
    ECgene: PASK H-InvDB: PASK

    (According to HUGE)
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    HUGE: KIAA0135

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PASK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PASK gene:
    Search GeneIP for patents involving PASK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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