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Aliases for PASK Gene

Aliases for PASK Gene

  • PAS Domain Containing Serine/Threonine Kinase 2 3 5
  • PASKIN 3 4
  • Per-Arnt-Sim (PAS) Domain Kinase 3
  • EC 2.7.11.1 4
  • PAS-Kinase 4
  • KIAA0135 4
  • STK37 3
  • HPASK 4

External Ids for PASK Gene

Previous GeneCards Identifiers for PASK Gene

  • GC02P239351
  • GC02P240214
  • GC02M242065
  • GC02M242366
  • GC02M241765
  • GC02M233801
  • GC02M242045

Summaries for PASK Gene

Entrez Gene Summary for PASK Gene

  • This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for PASK Gene

PASK (PAS Domain Containing Serine/Threonine Kinase) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PIM1.

UniProtKB/Swiss-Prot for PASK Gene

  • Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

Gene Wiki entry for PASK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PASK Gene

Genomics for PASK Gene

Regulatory Elements for PASK Gene

Promoters for PASK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PASK on UCSC Golden Path with GeneCards custom track

Genomic Location for PASK Gene

Chromosome:
2
Start:
241,106,099 bp from pter
End:
241,150,364 bp from pter
Size:
44,266 bases
Orientation:
Minus strand

Genomic View for PASK Gene

Genes around PASK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PASK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PASK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PASK Gene

Proteins for PASK Gene

  • Protein details for PASK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RG2-PASK_HUMAN
    Recommended name:
    PAS domain-containing serine/threonine-protein kinase
    Protein Accession:
    Q96RG2
    Secondary Accessions:
    • G5E9F1
    • Q05BE4
    • Q68DY3
    • Q6GSJ5
    • Q86XH6
    • Q99763
    • Q9UFR7

    Protein attributes for PASK Gene

    Size:
    1323 amino acids
    Molecular mass:
    142929 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09484.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PASK Gene

    Alternative splice isoforms for PASK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PASK Gene

Proteomics data for PASK Gene at MOPED

Post-translational modifications for PASK Gene

  • Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PASK (PASK)

No data available for DME Specific Peptides for PASK Gene

Domains & Families for PASK Gene

Gene Families for PASK Gene

Graphical View of Domain Structure for InterPro Entry

Q96RG2

UniProtKB/Swiss-Prot:

PASK_HUMAN :
  • The protein kinase domain mediates binding to phosphatidylinositol.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain mediates binding to phosphatidylinositol.
  • Contains 2 PAS (PER-ARNT-SIM) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PASK: view

Function for PASK Gene

Molecular function for PASK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

Enzyme Numbers (IUBMB) for PASK Gene

Gene Ontology (GO) - Molecular Function for PASK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PASK: view
genes like me logo Genes that share phenotypes with PASK: view

Animal Models for PASK Gene

MGI Knock Outs for PASK:

Animal Model Products

  • Taconic Biosciences Mouse Models for PASK

miRNA for PASK Gene

miRTarBase miRNAs that target PASK

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PASK Gene

Localization for PASK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PASK Gene

Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PASK Gene COMPARTMENTS Subcellular localization image for PASK gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for PASK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17595531
genes like me logo Genes that share ontologies with PASK: view

Pathways & Interactions for PASK Gene

SuperPathways for PASK Gene

No Data Available

SIGNOR curated interactions for PASK Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PASK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 16275910
GO:0043576 regulation of respiratory gaseous exchange ISS --
GO:0045727 positive regulation of translation TAS 17595531
genes like me logo Genes that share ontologies with PASK: view

No data available for Pathways by source for PASK Gene

Drugs & Compounds for PASK Gene

(2) Drugs for PASK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for PASK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PASK: view

Transcripts for PASK Gene

mRNA/cDNA for PASK Gene

(16) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PASK Gene

PAS domain containing serine/threonine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PASK Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ·
SP1: - - - - - -
SP2:
SP3: - - - - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11: -
SP12: -
SP13:
SP14:

ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PASK Gene

GeneLoc Exon Structure for
PASK
ECgene alternative splicing isoforms for
PASK

Expression for PASK Gene

mRNA expression in normal human tissues for PASK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PASK Gene

This gene is overexpressed in Testis (43.3), Retina (10.2), and Ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PASK Gene



SOURCE GeneReport for Unigene cluster for PASK Gene Hs.397891

mRNA Expression by UniProt/SwissProt for PASK Gene

Q96RG2-PASK_HUMAN
Tissue specificity: Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).
genes like me logo Genes that share expression patterns with PASK: view

Protein tissue co-expression partners for PASK Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PASK Gene

Orthologs for PASK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PASK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PASK 35
  • 98.95 (n)
  • 98.42 (a)
PASK 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PASK 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PASK 36
  • 63 (a)
OneToOne
PASK 35
  • 76.39 (n)
  • 69.89 (a)
mouse
(Mus musculus)
Mammalia Pask 36
  • 69 (a)
OneToOne
Pask 16
Pask 35
  • 76.92 (n)
  • 73.02 (a)
oppossum
(Monodelphis domestica)
Mammalia PASK 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PASK 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pask 35
  • 75.59 (n)
  • 71.46 (a)
chicken
(Gallus gallus)
Aves PASK 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PASK 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32341 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4074 35
zebrafish
(Danio rerio)
Actinopterygii pask 36
  • 33 (a)
OneToOne
wufb69h07 35
fruit fly
(Drosophila melanogaster)
Insecta Pask 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prk-1 36
  • 17 (a)
OneToMany
prk-2 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSK1 36
  • 17 (a)
OneToMany
PSK2 36
  • 19 (a)
OneToMany
PSK1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8570 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9130 36
  • 39 (a)
OneToOne
Species with no ortholog for PASK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PASK Gene

ENSEMBL:
Gene Tree for PASK (if available)
TreeFam:
Gene Tree for PASK (if available)

Paralogs for PASK Gene

Paralogs for PASK Gene

genes like me logo Genes that share paralogs with PASK: view

Variants for PASK Gene

Sequence variations from dbSNP and Humsavar for PASK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1470414 - 241,138,081(-) GCACC(A/G)TCACG intron-variant, nc-transcript-variant, reference, missense
rs2240543 - 241,127,374(+) TCCCC(A/G)AGGCA nc-transcript-variant, reference, missense
rs6727226 - 241,126,835(+) CGACA(C/T)AGGAG nc-transcript-variant, reference, missense
rs2005771 - 241,126,741(+) CCAGG(C/T)CCCCA nc-transcript-variant, reference, missense
VAR_028297 -

Structural Variations from Database of Genomic Variants (DGV) for PASK Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
esv2721976 CNV Deletion 23290073
esv1931784 CNV Deletion 18987734
nsv214964 CNV Loss 16902084
esv2721977 CNV Deletion 23290073
esv2721978 CNV Deletion 23290073
dgv687e201 CNV Deletion 23290073
esv2667460 CNV Deletion 23128226
esv2721981 CNV Deletion 23290073
esv2721982 CNV Deletion 23290073
esv2721983 CNV Deletion 23290073
esv2721985 CNV Deletion 23290073

Variation tolerance for PASK Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.96; 91.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PASK Gene

HapMap Linkage Disequilibrium report
PASK
Human Gene Mutation Database (HGMD)
PASK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PASK Gene

Disorders for PASK Gene

Relevant External Links for PASK

Genetic Association Database (GAD)
PASK
Human Genome Epidemiology (HuGE) Navigator
PASK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PASK

No disorders were found for PASK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PASK Gene

Publications for PASK Gene

  1. PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. (PMID: 11459942) Rutter J. … McKnight S.L. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 67
  2. Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. (PMID: 15148392) da Silva Xavier G. … Rutter G.A. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 23
  3. Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. (PMID: 11688972) Hofer T. … Wenger R.H. (Biochem. Biophys. Res. Commun. 2001) 2 3 23
  4. Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. (PMID: 17595531) Eckhardt K. … Wenger R.H. (Cell. Physiol. Biochem. 2007) 3 23
  5. Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. (PMID: 12377121) Amezcua C.A. … Gardner K.H. (Structure 2002) 3 23

Products for PASK Gene

Sources for PASK Gene

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