PASD1 Gene
protein-coding GIFtS: 45
GCID: GC0XP150732
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PAS domain containing 1
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Aliases
for PASD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PAS Domain Containing 11 2 | | CT631 2 3 | | Cancer/Testis Antigen 632 3 | | OXTES12 | | PAS Domain-Containing Protein 12 | | OX-TES-13 |
Export aliases for PASD1 gene to outside databasesPrevious GC identifers: GC0XP150402 GC0XP150482 GC0XP139588 |
Summaries
for PASD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PASD1:
This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associatedantigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potentialimmunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-celllymphoma. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: PASD1_HUMAN, Q8IV76Function: May function as a transcription factor
Gene Wiki entry for PASD1
|
Genomic Views
for PASD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PASD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PASD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PASD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28PASD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP150732: view genomic region
(about GC identifiers)
Start:
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150,732,007 bp from pter |
End:
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150,845,211 bp from pter |
Size:
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113,205 bases |
Orientation:
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plus strand |
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Proteins
for PASD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PASD1_HUMAN, Q8IV76 (See
protein sequence)Recommended Name: PAS domain-containing protein 1 Size: 773 amino acids; 87428 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q3MNE0 Q69HD7 Q8N7X9Alternative splicing: 2 isoforms: Q8IV76-1 Q8IV76-2 (Due to intron retention)Explore the universe of human proteins at neXtProt for PASD1: NX_Q8IV76
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IV76
PASD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775764.2
ENSEMBL proteins: ENSP00000359382
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
PASD1 for ontologies About GeneDecksing
PASD1 Antibody Products:
Assay Products for PASD1: |
Protein
Domains /
Families
for PASD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PASD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IV76ProtoNet protein and cluster: Q8IV76 UniProtKB/Swiss-Prot: PASD1_HUMAN, Q8IV76Similarity: Contains 1 PAS (PER-ARNT-SIM) domain |
Function
for PASD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PASD1_HUMAN, Q8IV76Function: May function as a transcription factor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PASD1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PASD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: PASD1 (NM_173493) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PASD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PASD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PASD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004871 | signal transducer activity |
IEA | -- |
PASD1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PASD1:
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Pathways & Interactions
for PASD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PASD1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PASD1 (ENSP000003593824) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for PASD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PASD1
Search CenterWatch for drugs/clinical trials and news about PASD1
|
Transcripts
for PASD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PASD1 gene: NM_173493.2 Unigene Cluster for PASD1: PAS domain containing 1 Hs.160594 [show with all ESTs]Unigene Representative Sequence: NM_1734932 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370357(uc004fev.4) ENST00000464219
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PASD1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PASD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PASD1 (NM_173493) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PASD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PASD1 |
Additional cDNA sequence: AK097552.1 AY623425.1 BC040301.1 2 DOTS entries: DT.100019667 DT.91958553 8 AceView cDNA sequences: BU622220 AA675906 AA909926 AI432364 AI425097 CA417836 CA430026 AW268858
GeneLoc Exon Structure
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Expression
for PASD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PASD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTACCACA
About this image
See PASD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PASD1
SOURCE GeneReport for Unigene cluster: Hs.160594
UniProtKB/Swiss-Prot: PASD1_HUMAN, Q8IV76Tissue specificity: Testis-specific. Found in histologically normal tissues from patients with uterus, lung and smallintestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived celllines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in celllines derived from non-germinal center DLBCL
SABiosciences Custom PCR Arrays for PASD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PASD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PASD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PASD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PASD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PASD1 |
Orthologs
for PASD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for PASD1 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gm11415 |
predicted gene 1141 |
-- |
|
X (37.14 cM) 71928816 |
ENSEMBL Gene Tree for PASD1 (if available)
TreeFam Gene Tree for PASD1 (if available) |
Paralogs
for PASD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PASD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PASD1 (150732007 - 150845211 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PASD1
1 CNV: 22856
Locus Specific Mutation Databases (LSDB): PASD1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PASD1 |
|
Disorders
/ Diseases
for PASD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PASD1 for disorders About GeneDecksing
7  diseases for PASD1: About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas small intestine cancer basal cell carcinoma
multiple myeloma myeloma carcinoma
1 disease from the University of Copenhagen DISEASES database for PASD1:Diffuse large B-cell lymphoma Export disorders for PASD1 gene to outside databases
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Publications
for PASD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PASD1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with PASD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. (PubMed id 15162151)1, 2, 3 Liggins A.P....Banham A.H. (2004)
- Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)1, 2 Guinn B.-A.... Mufti G.J. (2005)
- Serologic detection of diffuse large B-cell lymphoma-associated antigens. (PubMed id 15122589)1, 3 Liggins A.P....Banham A.H. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Elevated expression levels of testis-specific genes T EX101 and SPATA19 in basal cell carcinoma and their correlation with clinical a nd pathological features. (PubMed id 19886887)1 Ghafouri-Fard S....Modarressi M.H. (2010)
- DNA vaccines to target the cancer testis antigen PASD 1 in human multiple myeloma. (PubMed id 20861911)1 Joseph-Pietras D....Sahota S.S. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Cytolytic T-cell response to the PASD1 cancer testis antigen in patients with diffuse large B-cell lymphoma. (PubMed id 19552722)1 Ait-Tahar K....Pulford K. (2009)
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External Searches for PASD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PASD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PASD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PASD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PASD1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PASD1 gene:
Search GeneIP for patents involving PASD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PASD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PASD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PASD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PASD1 | | | OriGene Protein Over-expression Lysate for PASD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PASD1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PASD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PASD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PASD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PASD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PASD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PASD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PASD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PASD1 |
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 | | | PASD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PASD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for PASD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PASD1 |
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