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Aliases for PARVG Gene

Aliases for PARVG Gene

  • Parvin Gamma 2 3 5
  • Gamma-Parvin 3

External Ids for PARVG Gene

Previous GeneCards Identifiers for PARVG Gene

  • GC22P041194
  • GC22P042827
  • GC22P042835
  • GC22P042901
  • GC22P044568
  • GC22P027520

Summaries for PARVG Gene

Entrez Gene Summary for PARVG Gene

  • Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM, Aug 2004]

GeneCards Summary for PARVG Gene

PARVG (Parvin Gamma) is a Protein Coding gene. Among its related pathways are Focal Adhesion. GO annotations related to this gene include actin binding. An important paralog of this gene is PARVB.

UniProtKB/Swiss-Prot for PARVG Gene

  • Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.

Gene Wiki entry for PARVG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARVG Gene

Genomics for PARVG Gene

Regulatory Elements for PARVG Gene

Enhancers for PARVG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G044145 1.3 Ensembl ENCODE dbSUPER 8.7 -22.7 -22689 4.7 ESRRA NFIB SUZ12 TEAD4 ZMYM3 MAX RBBP5 ZIC2 ETS1 ZNF664 ENSG00000220702 PARVG TRU-TCA2-1 ENSG00000280434
GH22G044171 1.1 Ensembl ENCODE 7.5 +2.8 2846 3.1 HDGF PKNOX1 WRNIP1 RAD21 EGR1 RELB IKZF2 CREM EGR2 ZNF654 PARVG SAMM50 ENSG00000279933
GH22G044179 0.9 ENCODE 8.1 +11.5 11511 3.7 HDGF TBP PKNOX1 NFXL1 ZBTB40 RFX5 ZNF366 SCRT2 ZNF143 ZNF207 ENSG00000273243 PARVG SAMM50 ENSG00000279933
GH22G044550 1.3 FANTOM5 Ensembl ENCODE 4.3 +381.2 381213 2.0 TBP ZNF263 ZBED1 BHLHE40 CEBPB JUNB CEBPG NR2F2 ZFHX2 CEBPA RTL6 ENSG00000220702 KIAA1644 PARVG LOC105373059 GC22M044550
GH22G044129 0.9 Ensembl dbSUPER 5.6 -40.5 -40526 0.6 MAFG CEBPB REST ZKSCAN1 JUND RBAK FOS NFE2 EMSY PARVG ENSG00000280434 GC22P044108
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARVG on UCSC Golden Path with GeneCards custom track

Genomic Location for PARVG Gene

44,170,227 bp from pter
44,219,533 bp from pter
49,307 bases
Plus strand

Genomic View for PARVG Gene

Genes around PARVG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARVG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARVG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARVG Gene

Proteins for PARVG Gene

  • Protein details for PARVG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DDW5
    • E7EVM6
    • Q9BQX5
    • Q9NSG1

    Protein attributes for PARVG Gene

    331 amino acids
    Molecular mass:
    37485 Da
    Quaternary structure:
    • Interacts with integrin-linked protein kinase and actin.

    Alternative splice isoforms for PARVG Gene


neXtProt entry for PARVG Gene

Post-translational modifications for PARVG Gene

  • Ubiquitination at Lys213
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PARVG Gene

Domains & Families for PARVG Gene

Gene Families for PARVG Gene

Protein Domains for PARVG Gene

Suggested Antigen Peptide Sequences for PARVG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the parvin family.
  • Belongs to the parvin family.
genes like me logo Genes that share domains with PARVG: view

Function for PARVG Gene

Molecular function for PARVG Gene

UniProtKB/Swiss-Prot Function:
Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.

Gene Ontology (GO) - Molecular Function for PARVG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 11171322
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PARVG: view
genes like me logo Genes that share phenotypes with PARVG: view

Animal Models for PARVG Gene

MGI Knock Outs for PARVG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARVG Gene

Localization for PARVG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARVG Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Constituent of focal adhesions. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARVG gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PARVG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton TAS 11171322
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PARVG: view

Pathways & Interactions for PARVG Gene

SuperPathways for PARVG Gene

SuperPathway Contained pathways
1 Focal Adhesion
genes like me logo Genes that share pathways with PARVG: view

Pathways by source for PARVG Gene

1 KEGG pathway for PARVG Gene

Gene Ontology (GO) - Biological Process for PARVG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion TAS 11171322
GO:0031532 actin cytoskeleton reorganization IEA --
genes like me logo Genes that share ontologies with PARVG: view

No data available for SIGNOR curated interactions for PARVG Gene

Drugs & Compounds for PARVG Gene

No Compound Related Data Available

Transcripts for PARVG Gene

Unigene Clusters for PARVG Gene

Parvin, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARVG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b

Relevant External Links for PARVG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARVG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARVG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARVG Gene

This gene is overexpressed in Whole Blood (x16.8) and Spleen (x7.5).

Protein differential expression in normal tissues from HIPED for PARVG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.8), Monocytes (10.0), Spleen (8.0), NK cells (7.3), and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARVG Gene

Protein tissue co-expression partners for PARVG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARVG Gene:


SOURCE GeneReport for Unigene cluster for PARVG Gene:


mRNA Expression by UniProt/SwissProt for PARVG Gene:

Tissue specificity: Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues.

Evidence on tissue expression from TISSUES for PARVG Gene

  • Nervous system(4.5)
  • Spleen(4.4)
  • Lung(4.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with PARVG: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PARVG Gene

Orthologs for PARVG Gene

This gene was present in the common ancestor of animals.

Orthologs for PARVG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PARVG 34 35
  • 98.79 (n)
(Bos Taurus)
Mammalia PARVG 34
  • 84.79 (n)
MGC148449 35
  • 81 (a)
(Canis familiaris)
Mammalia PARVG 34 35
  • 84.39 (n)
(Mus musculus)
Mammalia Parvg 34 16 35
  • 81.87 (n)
(Rattus norvegicus)
Mammalia Parvg 34
  • 81.31 (n)
(Monodelphis domestica)
Mammalia PARVG 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PARVG 35
  • 59 (a)
(Gallus gallus)
Aves PARVG 34 35
  • 60.92 (n)
(Anolis carolinensis)
Reptilia PARVG 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia parvg 34
  • 64.61 (n)
(Danio rerio)
Actinopterygii parvg 34 35
  • 61.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32528 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea pat-6 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
Species where no ortholog for PARVG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARVG Gene

Gene Tree for PARVG (if available)
Gene Tree for PARVG (if available)

Paralogs for PARVG Gene

Paralogs for PARVG Gene

(2) SIMAP similar genes for PARVG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARVG: view

Variants for PARVG Gene

Sequence variations from dbSNP and Humsavar for PARVG Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000000265 -- 44,205,008(+) AGCCC(A/G)CTTTG intron-variant
rs1000066302 -- 44,171,451(+) GATCA(G/T)GCCAC upstream-variant-2KB, utr-variant-5-prime
rs1000102608 -- 44,187,951(+) CACAG(A/G)TAGGC intron-variant
rs1000145977 -- 44,169,660(+) GTCTC(A/C/T)CCTCT downstream-variant-500B, upstream-variant-2KB
rs1000191469 -- 44,190,727(+) ATTGC(C/T)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARVG Gene

Variant ID Type Subtype PubMed ID
nsv1059584 CNV gain 25217958
nsv508740 CNV insertion 20534489
nsv510518 OTHER sequence alteration 20534489
nsv9915 CNV loss 18304495

Variation tolerance for PARVG Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARVG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARVG Gene

Disorders for PARVG Gene

Relevant External Links for PARVG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PARVG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARVG Gene

Publications for PARVG Gene

  1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PMID: 11171322) Olski T.M. … Korenbaum E. (J. Cell Sci. 2001) 2 3 4 22 64
  2. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. (PMID: 11722847) Korenbaum E. … Noegel A.A. (Gene 2001) 3 4 22 64
  3. The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction. (PMID: 16517730) Yoshimi R. … Ishigatsubo Y. (J. Immunol. 2006) 3 22 64
  4. No evidence of INI1hSNF5 (SMARCB1) and PARVG point mutations in oligodendroglial neoplasms. (PMID: 15993274) Alonso M.E. … Rey J.A. (Cancer Genet. Cytogenet. 2005) 3 22 64
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64

Products for PARVG Gene

Sources for PARVG Gene

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