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PARVB Gene

protein-coding   GIFtS: 60
GCID: GC22P044395

Parvin, Beta

  See PARVB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Parvin, Beta1 2
affixin1 2
CGI-562
beta-parvin2
Affixin3

External Ids:    HGNC: 146531   Entrez Gene: 297802   Ensembl: ENSG000001886777   OMIM: 6081215   UniProtKB: Q9HBI13   

Export aliases for PARVB gene to outside databases

Previous GC identifers: GC22P041036 GC22P042653 GC22P042678 GC22P042545 GC22P042719 GC22P027349


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PARVB Gene:
This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton
organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology
domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit
the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of
this gene results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for PARVB Gene:
PARVB (parvin, beta) is a protein-coding gene. Diseases associated with PARVB include coronary restenosis. GO annotations related to this gene include actin binding. An important paralog of this gene is PARVA.

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1
Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42
and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin
cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or
maintenance of cell polarity, and cell migration

Gene Wiki entry for PARVB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARVB gene promoter:
         STAT1   AML1a   MyoD   POU3F2   YY1   PPAR-gamma1   c-Rel   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PARVB promoter sequence
   Search Chromatin IP Primers for PARVB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARVB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2-q13.33   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13.2-q13.33

PARVB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARVB gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P044395:  view genomic region     (about GC identifiers)

Start:
44,395,091 bp from pter      End:
44,568,829 bp from pter
Size:
173,739 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1 (See protein sequence)
Recommended Name: Beta-parvin  
Size: 364 amino acids; 41714 Da
Subunit: Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin
Sequence caution: Sequence=AAD34051.1; Type=Frameshift; Positions=4, 14, 48, 58, 155, 162, 171, 327, 331, 344;
Sequence=BG743702; Type=Frameshift; Positions=136, 232, 237;
3 PDB 3D structures from and Proteopedia for PARVB:
4EDL (3D)        4EDM (3D)        4EDN (3D)    
Secondary accessions: B0QYM8 B0QYN1 B2R9X6 Q5TGJ5 Q86X93 Q96PN1 Q9NSP7 Q9UGT3 Q9Y368 Q9Y3L6
Q9Y3L7
Alternative splicing: 3 isoforms:  Q9HBI1-1   Q9HBI1-2   Q9HBI1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PARVB: NX_Q9HBI1

Explore proteomics data for PARVB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PARVB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001003828.1  NP_001230314.1  NP_001230315.1  NP_037459.2  

    ENSEMBL proteins: 
     ENSP00000384515   ENSP00000342492   ENSP00000393758   ENSP00000384353  
    Reactome Protein details: Q9HBI1

    PARVB Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARV: Parvins

    2 InterPro protein domains:
     IPR028433 Parvin
     IPR001715 CH-domain

    Graphical View of Domain Structure for InterPro Entry Q9HBI1

    ProtoNet protein and cluster: Q9HBI1

    1 Blocks protein domain: IPB001715 Calponin-like actin-binding

    UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1
    Similarity: Belongs to the parvin family
    Similarity: Contains 2 CH (calponin-homology) domains


    Find genes that share domains with PARVB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARVB_HUMAN, Q9HBI1
    Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42
    and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin
    cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or
    maintenance of cell polarity, and cell migration

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI18325335
         
    Find genes that share ontologies with PARVB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PARVB:
     Decreased focal adhesion (FA)  

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Parvb):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  normal 
     other  skeleton 

    Find genes that share phenotypes with PARVB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Parvbtm1Ref for PARVB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARVB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARVB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARVB

    miRNA
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    hsa-let-7b-5p (MIRT032339)

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    SwitchGear 3'UTR luciferase reporter plasmidPARVB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PARVB

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PARVB_HUMAN, Q9HBI1: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
    Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril,
    sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells.
    Colocalizes with F-actin at the tips of lamellipodia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    nucleus2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IDA--
    GO:0030018Z disc IEA--

    Find genes that share ontologies with PARVB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARVB About    
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    2Cell junction organization
    Cell junction organization0.70
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components0.00
    Cell-Cell communication0.64
    Cell-extracellular matrix interactions0.00
    3ERK Signaling
    ILK Signaling0.49
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside in signaling0.37


    Find genes that share SuperPaths with PARVB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PARVB
        ILK Signaling

    1 GeneGo (Thomson Reuters) Pathway for PARVB
        Cytoskeleton remodeling Integrin outside-in signaling

    1 BioSystems Pathway for PARVB
        Focal Adhesion

    2 Reactome Pathways for PARVB
        Cell-extracellular matrix interactions
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


    1 Kegg Pathway  (Kegg details for PARVB):
        Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Array including PARVB: 
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PARVB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARVB (Q9HBI11, 2, 3 ENSP000003845154) via UniProtKB, MINT, STRING, and/or I2D (see all 810)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    Arhgef7Q9ES281, 2EBI-1047679,EBI-642580 MINT-6178962 MINT-6178760 MINT-6178832 MINT-6179002 MINT-6179212 MINT-6179203 MINT-6178983 MINT-6178812 MINT-6179021 MINT-6178859
    ILKQ134182, 3, ENSP000002994214MINT-7945693 I2D: score=5 STRING: ENSP00000299421
    CDC5LQ994592, ENSP000003605324MINT-7947479 MINT-7945693 STRING: ENSP00000360532
    FERMT1Q9BQL62, ENSP000002172894MINT-7945693 MINT-7947479 STRING: ENSP00000217289
    ACTBP607092, ENSP000003499604MINT-7947479 MINT-7945693 STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0030031cell projection assembly IMP15005707
    GO:0030032lamellipodium assembly IMP18325335
    GO:0031532actin cytoskeleton reorganization IMP15005707
    GO:0034329cell junction assembly TAS--

    Find genes that share ontologies with PARVB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PARVB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PARVB gene (4 alternative transcripts): 
    NM_001003828.2  NM_001243385.1  NM_001243386.1  NM_013327.4  

    Unigene Cluster for PARVB:

    Parvin, beta
    Hs.475074  [show with all ESTs]
    Unigene Representative Sequence: NM_001003828
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406477(uc003bem.3) ENST00000338758(uc003ben.3 uc010gzn.3)
    ENST00000402876 ENST00000444029 ENST00000404989(uc003beo.3) ENST00000477795
    ENST00000495824 ENST00000484345 ENST00000477438
    miRNA
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    Additional mRNA sequence: 

    AB048276.1 AF151814.1 AF237769.1 AF303887.1 AK308443.1 AK309987.1 AK313957.1 AL159142.1 
    BC017461.1 BC039811.1 BC046103.1 

    18 DOTS entries:

    DT.100029807  DT.315883  DT.100697693  DT.100827379  DT.100827373  DT.100827378  DT.120654157  DT.100757355 
    DT.100827374  DT.120654233  DT.100827381  DT.100842957  DT.40230653  DT.95201055  DT.92034580  DT.95201057 
    DT.99949385  DT.99949403 

    Selected AceView cDNA sequences (see all 285):

    BQ023391 CR621262 CR620083 BU782820 CR620643 CR619856 BM696204 BM916999 
    CR604955 BM661478 BU740475 BQ269137 CA952786 BQ185188 NM_001003828 BU785686 
    H55609 BX331636 CA308417 F25335 CR622038 BM694470 H55198 BM353793 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARVB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTCCCAG
    PARVB Expression
    About this image


    PARVB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Brain (Nervous System)
             Medulla Oblongata
    PARVB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARVB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475074

    UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1
    Tissue specificity: Expressed predominantly in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including PARVB: 
              Focal Adhesions in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat PARVB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARVB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PARVB gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Parvb1 , 5 parvin, beta1, 5 85.81(n)1
    92.86(a)1
      15 (39.78 cM)5
    1707361  NM_133167.31  NP_573395.11 
     842320435 
    chicken
    (Gallus gallus)
    Aves PARVB1 parvin, beta 79.52(n)
    91.43(a)
      418235  XM_416459.3  XP_416459.2 
    lizard
    (Anolis carolinensis)
    Reptilia PARVB6
    parvin, beta
    83(a)
    1 ↔ 1
    5(85783533-85845808)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.292742 Xenopus laevis, Similar to parvin, beta, clone IMAGE5542473, more 76.73(n)    BC045011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd02e012 wufd02e01 76.25(n)   325686  BC059481.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta parvin1 parvin 65.03(n)
    60.4(a)
      32990  NM_134508.2  NP_608352.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pat-63   -- 46(a)   IV(262009-264224)   --


    ENSEMBL Gene Tree for PARVB (if available)
    TreeFam Gene Tree for PARVB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARVB gene
    PARVA2  PARVG2  
    3 SIMAP similar genes for PARVB using alignment to 2 protein entries:     PARVB_HUMAN (see all proteins):
    PARVA    TUBA1C    PARVG

    Find genes that share paralogs with PARVB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARVB (see all 4570)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60066071,2
    C,F,H--44393093(+) GGATCT/CGCCCG 1 -- us2k110Minor allele frequency- C:0.13NS EA NA CSA WA 778
    rs1471871811,2
    --44393240(+) GGAGTA/GCGGGA 1 -- us2k10--------
    rs60064741,2
    C,F,A,H--44393241(+) GAGTGC/TGGGAC 1 -- us2k112Minor allele frequency- T:0.48NS EA WA NA CSA 749
    rs752885391,2
    C,F--44393355(+) ATTGAA/GAAAGT 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs60066081,2
    F,A,H--44393419(+) CATGCA/TTTACT 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1406461291,2
    C--44393473(+) CTTTCA/CGTCCT 1 -- us2k10--------
    rs81419501,2
    C,F,A,H--44393476(+) TCAGTC/TCTCCC 1 -- us2k112Minor allele frequency- T:0.03NS EA NA 1658
    rs1853020851,2
    --44393699(+) AGGCCA/GAGGTG 1 -- us2k10--------
    rs1428820731,2
    --44393760(+) AAACCC/TCACTT 1 -- us2k10--------
    rs1899425771,2
    --44393801(+) GGTGAC/GAGATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARVB (44395091 - 44568829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PARVB (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724345CNV Deletion23290073
    esv2672411CNV Deletion23128226
    esv2724342CNV Deletion23290073
    esv2676055CNV Deletion23128226
    esv2724344CNV Deletion23290073
    esv2724340CNV Deletion23290073
    esv1973166CNV Deletion18987734
    esv2724334CNV Deletion23290073
    esv2724341CNV Deletion23290073
    esv2724338CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608121    OMIM disorders: --

    1 disease for PARVB:    
    About MalaCards
    coronary restenosis


    Find genes that share disorders with PARVB           About GenesLikeMe

    1 Novoseek inferred disease relationship for PARVB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16314921 (1)

    Genetic Association Database (GAD): PARVB
    Human Genome Epidemiology (HuGE) Navigator: PARVB (1 document)

    Export disorders for PARVB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PARVB gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with PARVB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PubMed id 11171322)1, 2, 3, 9 Olski T.M.... Korenbaum E. (J. Cell Sci. 2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. (PubMed id 15835269)1, 2, 9 Matsuda C.... Hayashi Y.K. (J. Neuropathol. Exp. Neurol. 2005)
    4. Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. (PubMed id 15284246)1, 2, 9 Zhang Y.... Wu C. (J. Biol. Chem. 2004)
    5. Affixin activates Rac1 via betaPIX in C2C12 myoblast. (PubMed id 18325335)1, 2, 9 Matsuda C.... Hayashi Y.K. (FEBS Lett. 2008)
    6. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. (PubMed id 11402068)1, 2, 9 Yamaji S.... Ishigatsubo Y. (J. Cell Biol. 2001)
    7. Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. (PubMed id 15159419)1, 2, 9 Yamaji S....Ishigatsubo Y. (J. Cell Biol. 2004)
    8. The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. (PubMed id 15005707)1, 2, 9 Mishima W.... Ishigatsubo Y. (Genes Cells 2004)
    9. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. (PubMed id 11722847)1, 2, 9 Korenbaum E.... Noegel A.A. (Gene 2001)
    10. Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. (PubMed id 22869380)1, 2 Stiegler A.L....Boggon T.J. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 29780 HGNC: 14653 AceView: PARVB Ensembl:ENSG00000188677 euGenes: HUgn29780
    ECgene: PARVB Kegg: 29780 H-InvDB: PARVB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PARVB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PARVB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PARVB gene:
    Search GeneIP for patents involving PARVB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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