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Aliases for PARVB Gene

Aliases for PARVB Gene

  • Parvin, Beta 2 3
  • Affixin 2 3 4
  • Beta-Parvin 3
  • CGI-56 3

External Ids for PARVB Gene

Summaries for PARVB Gene

Entrez Gene Summary for PARVB Gene

  • This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for PARVB Gene

PARVB (Parvin, Beta) is a Protein Coding gene. Diseases associated with PARVB include coronary restenosis. Among its related pathways are ERK Signaling and Focal adhesion. GO annotations related to this gene include actin binding. An important paralog of this gene is PARVA.

UniProtKB/Swiss-Prot for PARVB Gene

  • Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.

Gene Wiki entry for PARVB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARVB Gene

Genomics for PARVB Gene

Genomic Location for PARVB Gene

Start:
43,999,211 bp from pter
End:
44,172,949 bp from pter
Size:
173,739 bases
Orientation:
Plus strand

Genomic View for PARVB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARVB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARVB Gene

Regulatory Elements for PARVB Gene

Proteins for PARVB Gene

  • Protein details for PARVB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBI1-PARVB_HUMAN
    Recommended name:
    Beta-parvin
    Protein Accession:
    Q9HBI1
    Secondary Accessions:
    • B0QYM8
    • B0QYN1
    • B2R9X6
    • Q5TGJ5
    • Q86X93
    • Q96PN1
    • Q9NSP7
    • Q9UGT3
    • Q9Y368
    • Q9Y3L6
    • Q9Y3L7

    Protein attributes for PARVB Gene

    Size:
    364 amino acids
    Molecular mass:
    41714 Da
    Quaternary structure:
    • Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin.
    SequenceCaution:
    • Sequence=AAD34051.1; Type=Frameshift; Positions=4, 14, 48, 58, 155, 162, 171, 327, 331, 344; Evidence={ECO:0000305}; Sequence=BG743702; Type=Frameshift; Positions=136, 232, 237; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARVB Gene

    Alternative splice isoforms for PARVB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARVB Gene

Proteomics data for PARVB Gene at MOPED

Post-translational modifications for PARVB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARVB Gene

No data available for DME Specific Peptides for PARVB Gene

Domains for PARVB Gene

Gene Families for PARVB Gene

HGNC:

Protein Domains for PARVB Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PARVB_HUMAN
Domain:
  • Contains 2 CH (calponin-homology) domains.:
    • Q9HBI1
Family:
  • Belongs to the parvin family.:
    • Q9HBI1
genes like me logo Genes that share domains with PARVB: view

Function for PARVB Gene

Molecular function for PARVB Gene

UniProtKB/Swiss-Prot Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.

Gene Ontology (GO) - Molecular Function for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 18325335
genes like me logo Genes that share ontologies with PARVB: view
genes like me logo Genes that share phenotypes with PARVB: view

Animal Models for PARVB Gene

MGI Knock Outs for PARVB:

miRNA for PARVB Gene

miRTarBase miRNAs that target PARVB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PARVB Gene

Localization for PARVB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARVB Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARVB Gene COMPARTMENTS Subcellular localization image for PARVB gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 22869380
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with PARVB: view

Pathways for PARVB Gene

genes like me logo Genes that share pathways with PARVB: view

Pathways by source for PARVB Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for PARVB Gene
1 Qiagen pathway for PARVB Gene
1 BioSystems pathway for PARVB Gene

Gene Ontology (GO) - Biological Process for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0030031 cell projection assembly IMP 15005707
GO:0030032 lamellipodium assembly IMP 18325335
GO:0031532 actin cytoskeleton reorganization IMP 15005707
GO:0034329 cell junction assembly TAS --
genes like me logo Genes that share ontologies with PARVB: view

Transcripts for PARVB Gene

Unigene Clusters for PARVB Gene

Parvin, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARVB Gene

No ASD Table

Relevant External Links for PARVB Gene

GeneLoc Exon Structure for
PARVB
ECgene alternative splicing isoforms for
PARVB

Expression for PARVB Gene

mRNA expression in normal human tissues for PARVB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARVB Gene

This gene is overexpressed in Muscle - Skeletal (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PARVB Gene

SOURCE GeneReport for Unigene cluster for PARVB Gene Hs.475074

mRNA Expression by UniProt/SwissProt for PARVB Gene

Q9HBI1-PARVB_HUMAN
Tissue specificity: Expressed predominantly in heart and skeletal muscle.
genes like me logo Genes that share expressions with PARVB: view

Orthologs for PARVB Gene

This gene was present in the common ancestor of animals.

Orthologs for PARVB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARVB 36
  • 99.18 (n)
  • 98.9 (a)
PARVB 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARVB 36
  • 87.09 (n)
  • 90.66 (a)
PARVB 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARVB 36
  • 88.69 (n)
  • 92.73 (a)
mouse
(Mus musculus)
Mammalia Parvb 36
  • 85.81 (n)
  • 92.86 (a)
Parvb 16
Parvb 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARVB 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parvb 36
  • 86.38 (n)
  • 92.57 (a)
chicken
(Gallus gallus)
Aves PARVB 36
  • 79.52 (n)
  • 91.43 (a)
PARVB 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARVB 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29274 36
tropical clawed frog
(Silurana tropicalis)
Amphibia parvb 36
  • 78.1 (n)
  • 86.86 (a)
Str.5959 36
zebrafish
(Danio rerio)
Actinopterygii parvb 36
  • 71.63 (n)
  • 77.08 (a)
parvb 37
  • 70 (a)
OneToOne
wufd02e01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002356 36
  • 64.05 (n)
  • 62.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32528 37
  • 54 (a)
OneToMany
parvin 36
  • 65.03 (n)
  • 60.4 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-6 37
  • 44 (a)
OneToMany
pat-6 38
  • 46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3317 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 59 (a)
OneToMany
Species with no ortholog for PARVB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARVB Gene

ENSEMBL:
Gene Tree for PARVB (if available)
TreeFam:
Gene Tree for PARVB (if available)

Paralogs for PARVB Gene

Paralogs for PARVB Gene

Selected SIMAP similar genes for PARVB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PARVB: view

Variants for PARVB Gene

Sequence variations from dbSNP and Humsavar for PARVB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs79470 -- 44,159,072(+) GAGAG(A/C)GAGCG intron-variant
rs79471 -- 44,159,148(+) ACCAG(A/G)TGCCT intron-variant
rs79472 -- 44,160,221(+) CTGTC(C/G)AGTGG intron-variant
rs130307 -- 44,066,072(+) AAAAG(C/G)TGCTA intron-variant
rs130308 -- 44,066,660(+) cgacc(A/C)ctcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARVB Gene

Variant ID Type Subtype PubMed ID
nsv834219 CNV Gain 17160897
nsv459895 CNV Gain 19166990
nsv471206 CNV Gain 18288195
esv2676055 CNV Deletion 23128226
esv991955 CNV Insertion 20482838
esv2724331 CNV Deletion 23290073
nsv915266 CNV Loss 21882294
esv2724332 CNV Deletion 23290073
esv2670736 CNV Deletion 23128226
nsv510809 CNV Loss 20534489
esv2724333 CNV Deletion 23290073
esv2005538 CNV Deletion 18987734
nsv820857 CNV Deletion 20802225
esv2724334 CNV Deletion 23290073
esv22732 CNV Gain 19812545
esv1420958 CNV Insertion 17803354
esv2356466 CNV Deletion 18987734
esv1973166 CNV Deletion 18987734
esv2724335 CNV Deletion 23290073
esv2724336 CNV Deletion 23290073
esv2724337 CNV Deletion 23290073
esv2724338 CNV Deletion 23290073
nsv915267 CNV Loss 21882294
esv2724340 CNV Deletion 23290073
esv2724341 CNV Deletion 23290073
nsv508740 CNV Insertion 20534489
nsv915268 CNV Loss 21882294
esv2724342 CNV Deletion 23290073
esv2724343 CNV Deletion 23290073
esv2724344 CNV Deletion 23290073
esv2724345 CNV Deletion 23290073
esv2672411 CNV Deletion 23128226
esv2660969 CNV Deletion 23128226
esv27983 CNV Loss 19812545

Relevant External Links for PARVB Gene

HapMap Linkage Disequilibrium report
PARVB

Disorders for PARVB Gene

(1) MalaCards Diseases for PARVB Gene

Search for PARVB Gene in MalaCards »

(1) Novoseek inferred disease relationships for PARVB Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for PARVB

Genetic Association Database (GAD)
PARVB
Human Genome Epidemiology (HuGE) Navigator
PARVB
genes like me logo Genes that share disorders with PARVB: view

No data available for UniProtKB/Swiss-Prot for PARVB Gene

Publications for PARVB Gene

  1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PMID: 11171322) Olski T.M. … Korenbaum E. (J. Cell Sci. 2001) 2 3 4 23
  2. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. (PMID: 11402068) Yamaji S. … Ishigatsubo Y. (J. Cell Biol. 2001) 3 4 23
  3. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. (PMID: 11722847) Korenbaum E. … Noegel A.A. (Gene 2001) 3 4 23
  4. The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. (PMID: 15005707) Mishima W. … Ishigatsubo Y. (Genes Cells 2004) 3 4 23
  5. Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. (PMID: 15159419) Yamaji S. … Ishigatsubo Y. (J. Cell Biol. 2004) 3 4 23

Products for PARVB Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PARVB
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PARVB
    • Block miRNA regulation of PARVB using miScript Target Protectors

    Sources for PARVB Gene

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