Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PARVB Gene

protein-coding   GIFtS: 60
GCID: GC22P044395

Parvin, Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Parvin, Beta1 2
affixin1 2
CGI-562
beta-parvin2
Affixin3

External Ids:    HGNC: 146531   Entrez Gene: 297802   Ensembl: ENSG000001886777   OMIM: 6081215   UniProtKB: Q9HBI13   

Export aliases for PARVB gene to outside databases

Previous GC identifers: GC22P041036 GC22P042653 GC22P042678 GC22P042545 GC22P042719 GC22P027349


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PARVB Gene:
This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton
organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology
domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit
the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of
this gene results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for PARVB Gene: 
PARVB (parvin, beta) is a protein-coding gene. Diseases associated with PARVB include eaf, and renal agenesis, and among its related super-pathways are Focal Adhesion and Cell-cell junction organization. GO annotations related to this gene include actin binding. An important paralog of this gene is PARVA.

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1
Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42
and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin
cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or
maintenance of cell polarity, and cell migration

Gene Wiki entry for PARVB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PARVB gene promoter:
         STAT1   AML1a   MyoD   POU3F2   YY1   PPAR-gamma1   c-Rel   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PARVB promoter sequence
   Search SABiosciences Chromatin IP Primers for PARVB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARVB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2-q13.33   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13.2-q13.33

PARVB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARVB gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P044395:  view genomic region     (about GC identifiers)

Start:
44,395,091 bp from pter      End:
44,565,106 bp from pter
Size:
170,016 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1 (See protein sequence)
Recommended Name: Beta-parvin  
Size: 364 amino acids; 41714 Da
Subunit: Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril,
sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells.
Colocalizes with F-actin at the tips of lamellipodia
Sequence caution: Sequence=AAD34051.1; Type=Frameshift; Positions=4, 14, 48, 58, 155, 162, 171, 327, 331, 344;
Sequence=BG743702; Type=Frameshift; Positions=136, 232, 237;
3 PDB 3D structures from and Proteopedia for PARVB:
4EDL (3D)        4EDM (3D)        4EDN (3D)    
Secondary accessions: B0QYM8 B0QYN1 B2R9X6 Q5TGJ5 Q86X93 Q96PN1 Q9NSP7 Q9UGT3 Q9Y368 Q9Y3L6
Q9Y3L7
Alternative splicing: 3 isoforms:  Q9HBI1-1   Q9HBI1-2   Q9HBI1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PARVB: NX_Q9HBI1

Explore proteomics data for PARVB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HBI1

  • PARVB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PARVB Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001003828.1  NP_001230314.1  NP_001230315.1  NP_037459.2  

    ENSEMBL proteins: 
     ENSP00000384515   ENSP00000342492   ENSP00000385331   ENSP00000393758   ENSP00000384353  
    Reactome Protein details: Q9HBI1
    Human Recombinant Protein Products for PARVB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PARVB
    OriGene Protein Over-expression Lysate for PARVB
    OriGene MassSpec for PARVB 
    OriGene Custom Protein Services for PARVB
    GenScript Custom Purified and Recombinant Proteins Services for PARVB
    Novus Biologicals PARVB Protein
    Novus Biologicals PARVB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IDA--
    GO:0030018Z disc IEA--

    PARVB for ontologies           About GeneDecksing



    PARVB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARVB
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PARVB
    OriGene Custom Antibody Services for PARVB
    GenScript Custom Superior Antibodies Services for PARVB
    Novus Biologicals PARVB Antibodies
    Abcam antibodies for PARVB
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for PARVB
    LSBio Antibodies in human, mouse, rat for PARVB 

    Assay Products for PARVB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PARVB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PARVB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PARV: Parvins

    1 InterPro protein domain:
     IPR001715 CH-domain

    Graphical View of Domain Structure for InterPro Entry Q9HBI1

    ProtoNet protein and cluster: Q9HBI1

    1 Blocks protein domain: IPB001715 Calponin-like actin-binding

    UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1
    Similarity: Belongs to the parvin family
    Similarity: Contains 2 CH (calponin-homology) domains


    PARVB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARVB_HUMAN, Q9HBI1
    Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42
    and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin
    cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or
    maintenance of cell polarity, and cell migration

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI18325335
         
    PARVB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PARVB:
     Decreased focal adhesion (FA)  

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Parvb):
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  normal 
     other  skeleton 

    PARVB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Parvbtm1Ref for PARVB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PARVB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PARVB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARVB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARVB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARVB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PARVB
    SwitchGear 3'UTR luciferase reporter plasmidPARVB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PARVB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARVB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PARVB
    Sirion Biotech Customized adenovirus for overexpression of PARVB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PARVB (see all 12)
    OriGene ORF clones in mouse, rat for PARVB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PARVB (NM_001003828)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARVB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARVB
    Sirion Biotech Customized lentivirus for stable overexpression of PARVB 
                         Customized lentivirus expression plasmids for stable overexpression of PARVB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PARVB
    Search LifeMap BioReagents cell lines for PARVB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARVB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PARVB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    2Cell-cell junction organization
    Cell junction organization0.69
    Cell-Cell communication0.64
    3Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components0.44
    Cell-extracellular matrix interactions0.44
    4Rho Family GTPases
    ILK Signaling0.49
    5Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PARVB
        Cytoskeleton remodeling Integrin outside-in signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PARVB
        ILK Signaling

    1 GeneGo (Thomson Reuters) Pathway for PARVB
        Cytoskeleton remodeling Integrin outside-in signaling

    1 BioSystems Pathway for PARVB
        Focal Adhesion

    4        Reactome Pathways for PARVB
        Cell-extracellular matrix interactions
    Cell junction organization
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Cell-Cell communication


    1         Kegg Pathway  (Kegg details for PARVB):
        Focal adhesion


    PARVB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PARVB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/802 Interacting proteins for PARVB (Q9HBI12, 3 ENSP000003845154) via UniProtKB, MINT, STRING, and/or I2D (see all 802)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134182, 3, ENSP000002994214MINT-7945693 I2D: score=5 STRING: ENSP00000299421
    CDC5LQ994592, ENSP000003605324MINT-7947479 MINT-7945693 STRING: ENSP00000360532
    ACTBP607092, ENSP000003499604MINT-7947479 MINT-7945693 STRING: ENSP00000349960
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ARHGEF6Q150523, ENSP000002506174I2D: score=3 STRING: ENSP00000250617
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0030031cell projection assembly IMP15005707
    GO:0030032lamellipodium assembly IMP18325335
    GO:0031532actin cytoskeleton reorganization IMP15005707
    GO:0034329cell junction assembly TAS--

    PARVB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PARVB

    Search CenterWatch for drugs/clinical trials and news about PARVB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PARVB gene (4 alternative transcripts): 
    NM_001003828.2  NM_001243385.1  NM_001243386.1  NM_013327.4  

    Unigene Cluster for PARVB:

    Parvin, beta
    Hs.475074  [show with all ESTs]
    Unigene Representative Sequence: NM_001003828
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406477(uc003bem.3) ENST00000338758(uc003ben.3 uc010gzn.3)
    ENST00000402876 ENST00000444029 ENST00000404989(uc003beo.3) ENST00000477795
    ENST00000495824 ENST00000484345 ENST00000477438
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARVB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PARVB
    SwitchGear 3'UTR luciferase reporter plasmidPARVB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PARVB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARVB
    Clone
    Products:
         
    OriGene clones in human, mouse for PARVB (see all 12)
    OriGene ORF clones in mouse, rat for PARVB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PARVB (NM_001003828)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARVB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARVB
    Sirion Biotech Customized lentivirus for stable overexpression of PARVB 
                         Customized lentivirus expression plasmids for stable overexpression of PARVB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PARVB
    OriGene qSTAR qPCR primer pairs in human, mouse for PARVB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PARVB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARVB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARVB

    Additional mRNA sequence: 

    AB048276.1 AF151814.1 AF237769.1 AF303887.1 AK308443.1 AK309987.1 AK313957.1 AL159142.1 
    BC017461.1 BC039811.1 BC046103.1 

    18 DOTS entries:

    DT.100029807  DT.315883  DT.100697693  DT.100827379  DT.120654157  DT.100827373  DT.100827378  DT.100757355 
    DT.100827374  DT.120654233  DT.100827381  DT.100842957  DT.40230653  DT.95201055  DT.92034580  DT.95201057 
    DT.99949385  DT.99949403 

    24/285 AceView cDNA sequences (see all 285):

    H55198 CA308417 BX349799 BM661478 BU782820 CR597010 BM696204 CD370206 
    CR606501 AI754438 BQ268871 CR622750 BU784589 BQ023391 BM694470 CA950511 
    CR621262 BM510734 BU786315 CR620643 CD515533 BM353793 BQ269137 CR619856 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARVB expression in normal human tissues (normalized intensities)      PARVB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTCCCAG
    PARVB Expression
    About this image


    PARVB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Medulla Oblongata
             ganglion/cranial/facial VII   
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             monocyte-derived dendritic cells   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   

    See PARVB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PARVB

    SOURCE GeneReport for Unigene cluster: Hs.475074

    UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1
    Tissue specificity: Expressed predominantly in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including PARVB: 
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PARVB
    OriGene qSTAR qPCR primer pairs in human, mouse for PARVB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PARVB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARVB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARVB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARVB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PARVB gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Parvb1 , 5 parvin, beta1, 5 85.9(n)1
    92.31(a)1
      15 (39.78 cM)5
    1707361  NM_133167.31  NP_573395.11 
     842320435 
    chicken
    (Gallus gallus)
    Aves PARVB1 parvin, beta 79.58(n)
    91.21(a)
      418235  XM_416459.2  XP_416459.2 
    lizard
    (Anolis carolinensis)
    Reptilia PARVB6
    parvin, beta
    83(a)
    1 ↔ 1
    5(85783533-85845808)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.292742 Xenopus laevis, Similar to parvin, beta, clone IMAGE5542473, more 76.73(n)    BC045011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd02e012 wufd02e01 76.25(n)   325686  BC059481.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG325281 CG32528 64.33(n)
    59.94(a)
      32990  NM_134508.2  NP_608352.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pat-61 , 3 Protein PAT-61 46(a)3
    52.51(n)1
    49.72(a)1
      IV(262009-264224)3
    1768481  NM_067490.41  NP_499891.11 


    ENSEMBL Gene Tree for PARVB (if available)
    TreeFam Gene Tree for PARVB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PARVB gene
    PARVA2  PARVG2  
    3 SIMAP similar genes for PARVB using alignment to 3 protein entries:     PARVB_HUMAN (see all proteins):
    PARVA    TUBA1C    PARVG

    PARVB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4570 SNPs in PARVB are shown (see all 4570)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60066071,2
    C,F,H--44393093(+) GGATCT/CGCCCG 1 -- us2k110Minor allele frequency- C:0.13NS EA NA CSA WA 778
    rs1471871811,2
    --44393240(+) GGAGTA/GCGGGA 1 -- us2k10--------
    rs60064741,2
    C,F,A,H--44393241(+) GAGTGC/TGGGAC 1 -- us2k112Minor allele frequency- T:0.48NS EA WA NA CSA 749
    rs752885391,2
    C,F--44393355(+) ATTGAA/GAAAGT 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs60066081,2
    F,A,H--44393419(+) CATGCA/TTTACT 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1406461291,2
    C--44393473(+) CTTTCA/CGTCCT 1 -- us2k10--------
    rs81419501,2
    C,F,A,H--44393476(+) TCAGTC/TCTCCC 1 -- us2k112Minor allele frequency- T:0.03NS EA NA 1658
    rs1853020851,2
    --44393699(+) AGGCCA/GAGGTG 1 -- us2k10--------
    rs1428820731,2
    --44393760(+) AAACCC/TCACTT 1 -- us2k10--------
    rs1899425771,2
    --44393801(+) GGTGAC/GAGATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARVB (44395091 - 44565106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for PARVB (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724345CNV Deletion23290073
    esv2672411CNV Deletion23128226
    esv2724342CNV Deletion23290073
    esv2676055CNV Deletion23128226
    esv2724344CNV Deletion23290073
    esv2724340CNV Deletion23290073
    esv1973166CNV Deletion18987734
    esv2724334CNV Deletion23290073
    esv2724341CNV Deletion23290073
    esv2724338CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PARVB
    DNA2.0 Custom Variant and Variant Library Synthesis for PARVB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608121    OMIM disorders: --

    8 diseases for PARVB:    About MalaCards
    eaf    renal agenesis    chondrosarcoma    fatty liver disease
    dilated cardiomyopathy    liver disease    alcoholism    breast cancer


    PARVB for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PARVB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16314921 (1)

    Genetic Association Database (GAD): PARVB
    Human Genome Epidemiology (HuGE) Navigator: PARVB (1 document)

    Export disorders for PARVB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARVB gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with PARVB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PubMed id 11171322)1, 2, 3, 9 Olski T.M....Korenbaum E. (2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. (PubMed id 15835269)1, 2, 9 Matsuda C.... Hayashi Y.K. (2005)
    4. Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. (PubMed id 15284246)1, 2, 9 Zhang Y....Wu C. (2004)
    5. Affixin activates Rac1 via betaPIX in C2C12 myoblast. (PubMed id 18325335)1, 2, 9 Matsuda C....Hayashi Y.K. (2008)
    6. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. (PubMed id 11402068)1, 2, 9 Yamaji S.... Ishigatsubo Y. (2001)
    7. Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. (PubMed id 15159419)1, 2, 9 Yamaji S....Ishigatsubo Y. (2004)
    8. The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. (PubMed id 15005707)1, 2, 9 Mishima W....Ishigatsubo Y. (2004)
    9. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. (PubMed id 11722847)1, 2, 9 Korenbaum E.... Noegel A.A. (2001)
    10. Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. (PubMed id 22869380)1, 2 Stiegler A.L....Boggon T.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29780 HGNC: 14653 AceView: PARVB Ensembl:ENSG00000188677 euGenes: HUgn29780
    ECgene: PARVB Kegg: 29780 H-InvDB: PARVB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PARVB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PARVB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PARVB gene:
    Search GeneIP for patents involving PARVB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PARVB
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PARVB   OriGene RNAi products in human, mouse, rat for PARVB  
     OriGene qPCR primer pairs and template standards for PARVB   OriGene Protein Over-expression Lysate for PARVB  
     OriGene MassSpec something-or-other for PARVB   OriGene clones in human, mouse for PARVB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PARVB   OriGene Purified Protein for PARVB  
     OriGene ORF clones in mouse, rat for PARVB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PARVB   OriGene Custom Protein Services for PARVB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PARVB
     QIAGEN SeqTarget long-range PCR primers for resequencing PARVB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARVB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARVB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARVB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARVB
     GenScript Custom Purified and Recombinant Proteins Services for PARVB GenScript cDNA clones with any tag delivered in your preferred vector for PARVB
     GenScript Custom Assay Services for PARVB GenScript Custom Superior Antibodies Services for PARVB
     GenScript Custom overexpressing Cell Line Services for PARVB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PARVB promoter
     Search Chromatin IP Primers for PARVB
     RT2 qPCR Primer Assay in human, mouse, rat PARVB
     GNC Network for PARVB
     SABiosciences PCR Arrays including human, mouse, rat PARVB
     Search Tocris compounds for PARVB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PARVB antibodies
     PARVB proteins
     PARVB lysates
     Antibodies for PARVB
     See all of Abcam's Antibodies, Kits and Proteins for PARVB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PARVB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARVB
     SwitchGear 3'UTR luciferase reporter plasmids for PARVB
     SwitchGear Promoter luciferase reporter plasmids for PARVB
     Search ThermoFisher Antibodies for PARVB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARVB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PARVB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PARVB
    Customized:
     lentivirus for stable overexpression of PARVB
     lentivirus expression plasmids for stable overexpression of PARVB
     adenovirus for overexpression of PARVB
     LSBio Antibodies in human, mouse, rat for PARVB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PARVB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4