External Ids for PARVB Gene
This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for PARVB Gene
PARVB (Parvin, Beta) is a Protein Coding gene. Diseases associated with PARVB include coronary restenosis. Among its related pathways are ERK Signaling and Focal adhesion. GO annotations related to this gene include actin binding. An important paralog of this gene is PARVA.
UniProtKB/Swiss-Prot for PARVB Gene
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.