Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PARVB Gene

protein-coding GIFtS: 60
GCID: GC22P044395

parvin, beta

Explore 7 diseases affiliated with
PARVB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Parvin, Beta¹ ²
CGI-56¹ ²
Affixin³
Beta-Parvin¹
Affixin³

External Ids:	HGNC: 14653¹	Entrez Gene: 29780²	Ensembl: ENSG00000188677⁷	OMIM: 608121⁵	UniProtKB: Q9HBI1³

Export aliases for PARVB gene to outside databases

Previous GC identifers: GC22P041036 GC22P042653 GC22P042678 GC22P042545 GC22P042719 GC22P027349

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PARVB:

This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton

organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology

domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the

activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this

gene results in multiple transcript variants. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1

Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and

RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and

formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell

polarity, and cell migration

Gene Wiki entry for PARVB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PARVB gene promoter:
STAT1 AML1a MyoD POU3F2 YY1 PPAR-gamma1 c-Rel ARP-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PARVB promoter sequence

Search SABiosciences Chromatin IP Primers for PARVB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARVB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2-q13.33 Ensembl cytogenetic band: 22q13.31 HGNC cytogenetic band: 22q13.2-q13.33

PARVB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARVB gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P044395: view genomic region (about GC identifiers)

Start:	44,395,091 bp from pter	End:	44,565,106 bp from pter
Size:	170,016 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1 (See protein sequence)

Recommended Name: Beta-parvin

Size: 364 amino acids; 41714 Da

Subunit: Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin

Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril,

sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes

with F-actin at the tips of lamellipodia

Sequence caution: Sequence=AAD34051.1; Type=Frameshift; Positions=4, 14, 48, 58, 155, 162, 171, 327, 331, 344;

Sequence=BG743702; Type=Frameshift; Positions=136, 232, 237;

3 PDB 3D structures from and Proteopedia for PARVB:

4EDL (3D)

4EDM (3D)

4EDN (3D)

Secondary accessions: B0QYM8 B0QYN1 B2R9X6 Q5TGJ5 Q86X93 Q96PN1 Q9NSP7 Q9UGT3 Q9Y368 Q9Y3L6 Q9Y3L7

Alternative splicing: 3 isoforms: Q9HBI1-1 Q9HBI1-2 Q9HBI1-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PARVB: NX_Q9HBI1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBI1

PARVB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001003828.1 NP_001230314.1 NP_001230315.1 NP_037459.2

ENSEMBL proteins:

ENSP00000384515 ENSP00000342492 ENSP00000385331 ENSP00000393758 ENSP00000384353

Reactome Protein details: Q9HBI1
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PARVB OriGene Protein Over-expression Lysate: PARVB OriGene Custom Protein Services for PARVB
	GenScript Custom Purified and Recombinant Proteins Services for PARVB
	Novus Biologicals PARVB Protein Novus Biologicals PARVB Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005925	focal adhesion	IDA	--
GO:0030018	Z disc	IEA	--

PARVB for ontologies About GeneDecksing

PARVB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PARVB
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 4): PARVB OriGene Custom Antibody Services for PARVB
	GenScript Custom Superior Antibodies Services for PARVB
	Novus Biologicals PARVB Antibodies
	Abcam antibodies for PARVB
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for PARVB

Assay Products for PARVB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PARVB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PARVB for domains About GeneDecksing

1 InterPro domain/family:

IPR001715 CH-domain

Graphical View of Domain Structure for InterPro Entry Q9HBI1

ProtoNet protein and cluster: Q9HBI1

1 Blocks protein family: IPB001715 Calponin-like actin-binding

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1

Similarity: Belongs to the parvin family

Similarity: Contains 2 CH (calponin-homology) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1

Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and

RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and

formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell

polarity, and cell migration

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PARVB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARVB
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PARVB
		SwitchGear 3'UTR luciferase reporter plasmid: PARVB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PARVB (see all 7) OriGene shRNA RFP: PARVB OriGene siRNA: PARVB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARVB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PARVB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PARVB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PARVB (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PARVB (NM_001003828)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARVB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARVB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PARVB
		Search LifeMap BioReagents cell lines for PARVB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARVB

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

PARVB for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PARVB:

Decreased focal adhesion (FA)

Animal Models:
Mouse knock-out Parvb^tm1Ref for PARVB
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Parvb):

growth/size	hematopoietic system	homeostasis/metabolism	immune system	normal
other	skeleton

PARVB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

1.00

Cell-extracellular matrix interactions

0.44

Focal Adhesion

Focal Adhesion

1.00

Focal adhesion

0.66

Cell-cell junction organization

Cell junction organization

0.69

Cell-Cell communication

0.45

Cell adhesion_Integrin-mediated cell adhesion and migration

Cytoskeleton remodeling Integrin outside-in signaling

0.37

Cytoskeleton remodeling_Integrin outside-in signaling

0.37

Rho Family GTPases

ILK Signaling

0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PARVB

Cytoskeleton remodeling Integrin outside-in signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PARVB

ILK Signaling

1 GeneGo (Thomson Reuters) Pathway for PARVB

Cytoskeleton remodeling Integrin outside-in signaling

1 BioSystems Pathway for PARVB

Focal Adhesion

4 Reactome Pathways for PARVB

	Cell-extracellular matrix interactions
	Cell junction organization
	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
	Cell-Cell communication

1 Kegg Pathway (Kegg details for PARVB):

Focal adhesion

PARVB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PARVB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/765 Interacting proteins for PARVB (Q9HBI1^{2, 3} ENSP00000384515⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 765)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ILK	Q13418²^,³, ENSP00000299421⁴	MINT-7945693 I2D: score=5 STRING: ENSP00000299421
CDC5L	Q99459², ENSP00000360532⁴	MINT-7947479 MINT-7945693 STRING: ENSP00000360532
ACTB	P60709², ENSP00000349960⁴	MINT-7947479 MINT-7945693 STRING: ENSP00000349960
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531
ARHGEF6	Q15052³, ENSP00000250617⁴	I2D: score=3 STRING: ENSP00000250617

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0030031	cell projection assembly	IMP	15005707
GO:0030032	lamellipodium assembly	IMP	18325335
GO:0031532	actin cytoskeleton reorganization	IMP	15005707
GO:0034329	cell junction assembly	TAS	--

PARVB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PARVB
Search CenterWatch for drugs/clinical trials and news about PARVB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PARVB gene (4 alternative transcripts):

NM_001003828.2 NM_001243385.1 NM_001243386.1 NM_013327.4

Unigene Cluster for PARVB:

Parvin, beta

Hs.475074 [show with all ESTs]

Unigene Representative Sequence: NM_001003828

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000406477(uc003bem.3) ENST00000338758(uc003ben.3 uc010gzn.3)

ENST00000402876 ENST00000444029 ENST00000404989(uc003beo.3) ENST00000477795

ENST00000495824 ENST00000484345 ENST00000477438

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PARVB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARVB
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PARVB
		SwitchGear 3'UTR luciferase reporter plasmid: PARVB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PARVB (see all 7) OriGene shRNA RFP: PARVB OriGene siRNA: PARVB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARVB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PARVB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PARVB (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PARVB (NM_001003828)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARVB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARVB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PARVB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PARVB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARVB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARVB

Additional cDNA sequence:

AB048276.1 AF151814.1 AF237769.1 AF303887.1 AK308443.1 AK309987.1 AK313957.1 AL159142.1

BC017461.1 BC039811.1 BC046103.1

18 DOTS entries:

DT.100029807 DT.315883 DT.100697693 DT.100827379 DT.120654157 DT.100827373 DT.100827378 DT.100757355

DT.100827374 DT.120654233 DT.100827381 DT.100842957 DT.40230653 DT.95201055 DT.92034580 DT.95201057

DT.99949385 DT.99949403

24/285 AceView cDNA sequences (see all 285):

H55609 AI754438 CA308417 BU789585 BU782820 T30762 AL159142 BU754397

CR622038 CR622750 BM661478 CR620643 CD370206 BU786315 CR626839 BM510734

AB048276 BQ023391 BM696204 CR597010 H55198 F35741 BX331636 BX349799

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PARVB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTTCCCAG

About this image

PARVB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Brain

Eye

Limb

Liver

Diencephalic Roof Plate

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PARVB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PARVB

SOURCE GeneReport for Unigene cluster: Hs.475074

UniProtKB/Swiss-Prot: PARVB_HUMAN, Q9HBI1

Tissue specificity: Expressed predominantly in heart and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including PARVB:

Focal Adhesions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PARVB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PARVB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARVB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARVB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARVB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PARVB gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PARVB¹	parvin, beta	79.58(n) 91.21(a)		418235 XM_416459.2 XP_416459.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	94(a) 78(a)	1 ↔ many 1 ↔ many	5(85785009-85795592) 5(85799236-85811408)
African clawed frog (Xenopus laevis)	Amphibia	Xl.29274²	Xenopus laevis, Similar to parvin, beta, clone IMAGE5542473, more	76.73(n)		BC045011.1
zebrafish (Danio rerio)	Actinopterygii	wufd02e01²	wufd02e01	76.25(n)		325686 BC059481.1
fruit fly (Drosophila melanogaster)	Insecta	CG32528¹	CG32528	64.33(n) 59.94(a)		32990 NM_134508.2 NP_608352.2
worm (Caenorhabditis elegans)	Secernentea	pat-6^{1 , 3}	Protein PAT-6¹	46(a)³ 52.51(n)¹ 49.72(a)¹		IV(262009-264224)³ 176848¹ NM_067490.4¹ NP_499891.1¹

ENSEMBL Gene Tree for PARVB (if available)
TreeFam Gene Tree for PARVB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PARVB gene

PARVA² PARVG²

3 SIMAP similar genes for PARVB using alignment to 3 protein entries: PARVB_HUMAN (see all proteins):

PARVA TUBA1C PARVG

PARVB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6006607^1,2	C,F,H,	--	44393093(+)	`GGATCT/CGCCCG`	1	--	us2k¹		10		NS EA NA CSA WA	778
rs147187181^1,2		--	44393240(+)	`GGAGTA/GCGGGA`	1	--	us2k¹		0	--	--	--	--
rs6006474^1,2	C,F,A,H,	--	44393241(+)	`GAGTGC/TGGGAC`	1	--	us2k¹		12		NS EA WA NA CSA	749
rs75288539^1,2	F,	--	44393355(+)	`ATTGAA/GAAAGT`	1	--	us2k¹		1		WA	118
rs6006608^1,2	A,H,	--	44393419(+)	`CATGCA/TTTACT`	1	--	us2k¹		4		NS EA	420
rs140646129^1,2		--	44393473(+)	`CTTTCA/CGTCCT`	1	--	us2k¹		0	--	--	--	--
rs8141950^1,2	C,F,A,H,	--	44393476(+)	`TCAGTC/TCTCCC`	1	--	us2k¹		12		NS EA NA	1658
rs185302085^1,2		--	44393699(+)	`AGGCCA/GAGGTG`	1	--	us2k¹		0	--	--	--	--
rs142882073^1,2		--	44393760(+)	`AAACCC/TCACTT`	1	--	us2k¹		0	--	--	--	--
rs189942577^1,2		--	44393801(+)	`GGTGAC/GAGATG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PARVB (44395091 - 44565106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PARVB
3 CNVs: 44074 44073 73835
3 Indels: 40506 67899 46234

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PARVB

DNA2.0 Custom Variant and Variant Library Synthesis for PARVB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PARVB for disorders           About GeneDecksing

OMIM gene information: 608121    OMIM disorders: --

7 diseases for PARVB:    About MalaCards

renal agenesis dilated cardiomyopathy eaf cardiomyopathy

chondrosarcoma breast cancer carcinoma

1 Novoseek disease relationship for PARVB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	16314921 (1)

Human Genome Epidemiology (HuGE) Navigator: PARVB (1 document)

Export disorders for PARVB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PARVB gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with PARVB)

Utopia: connect your pdf to the dynamic
world of online information

Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PubMed id 11171322)^{1, 2, 3, 9} Olski T.M....Korenbaum E. (2001)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.H....Lin W. (2000)
Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. (PubMed id 15835269)^{1, 2, 9} Matsuda C.... Hayashi Y.K. (2005)
Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. (PubMed id 15284246)^{1, 2, 9} Zhang Y....Wu C. (2004)
Affixin activates Rac1 via betaPIX in C2C12 myoblast. (PubMed id 18325335)^{1, 2, 9} Matsuda C....Hayashi Y.K. (2008)
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. (PubMed id 11402068)^{1, 2, 9} Yamaji S.... Ishigatsubo Y. (2001)
Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. (PubMed id 15159419)^{1, 2, 9} Yamaji S....Ishigatsubo Y. (2004)
The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. (PubMed id 15005707)^{1, 2, 9} Mishima W....Ishigatsubo Y. (2004)
Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. (PubMed id 11722847)^{1, 2, 9} Korenbaum E.... Noegel A.A. (2001)
Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. (PubMed id 22869380)^{1, 2} Stiegler A.L....Boggon T.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29780	HGNC: 14653	AceView: PARVB	Ensembl:ENSG00000188677	euGenes: HUgn29780
ECgene: PARVB	Kegg: 29780	H-InvDB: PARVB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PARVB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PARVB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PARVB gene:
Search GeneIP for patents involving PARVB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of PARVB
	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for PARVB		OriGene shRNA RFP for PARVB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PARVB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PARVB
	OriGene Protein Over-expression Lysate for PARVB		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PARVB		OriGene 3'-UTR Clone for PARVB
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PARVB		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PARVB
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for PARVB		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PARVB		OriGene Custom Protein Services for PARVB
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PARVB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PARVB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARVB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARVB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARVB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARVB

	GenScript Custom Purified and Recombinant Proteins Services for PARVB		GenScript cDNA clones with any tag delivered in your preferred vector for PARVB
	GenScript Custom Assay Services for PARVB		GenScript Custom Superior Antibodies Services for PARVB
	GenScript Custom overexpressing Cell Line Services for PARVB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PARVB promoter
	Search Chromatin IP Primers for PARVB
	RT² qPCR Primer Assay in human, mouse, rat PARVB
	GNC Network for PARVB
	SABiosciences PCR Arrays including human, mouse, rat PARVB

Search Tocris compounds for PARVB

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PARVB antibodies
	PARVB proteins
	PARVB lysates

	Antibodies for PARVB
	See all of Abcam's Antibodies, Kits and Proteins for PARVB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for PARVB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARVB

	SwitchGear 3'UTR luciferase reporter plasmids for PARVB
	SwitchGear Promoter luciferase reporter plasmids for PARVB

Search ThermoFisher Antibodies for PARVB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARVB

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PARVB gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

PARVB Gene

parvin, beta

Aliases
for PARVB gene

Summaries
for PARVB gene

Genomic Views
for PARVB gene

Proteins
for PARVB gene

Protein Domains /
Families
for PARVB gene

Function
for PARVB gene

Pathways & Interactions
for PARVB gene

Drugs & Compounds
for PARVB gene

Transcripts
for PARVB gene

Expression
for PARVB gene

Orthologs
for PARVB gene

Paralogs
for PARVB gene

Genomic Variants
for PARVB gene

Disorders / Diseases
for PARVB gene

Publications
for PARVB gene

External Searches for PARVB gene

Genome Databases showing PARVB gene

Other Databases showing PARVB gene

Specialized Databases showing PARVB gene

Intellectual Property
for PARVB gene

Products
for PARVB gene

View Random Gene

Advanced Search

Export list of displayed genes

PARVB Gene

parvin, beta

Aliasesfor PARVB gene

Summariesfor PARVB gene

Genomic Viewsfor PARVB gene

Proteinsfor PARVB gene

Protein Domains /Familiesfor PARVB gene

Functionfor PARVB gene

Pathways & Interactionsfor PARVB gene

Drugs & Compoundsfor PARVB gene

Transcriptsfor PARVB gene

Expression for PARVB gene

Orthologsfor PARVB gene

Paralogsfor PARVB gene

Genomic Variantsfor PARVB gene

Disorders / Diseasesfor PARVB gene

Publicationsfor PARVB gene

External Searches for PARVB gene

Genome Databases showing PARVB gene

Other Databases showing PARVB gene

Specialized Databases showing PARVB gene

Intellectual Propertyfor PARVB gene

Productsfor PARVB gene

View Random Gene

Aliases
for PARVB gene

Summaries
for PARVB gene

Genomic Views
for PARVB gene

Proteins
for PARVB gene

Protein Domains /
Families
for PARVB gene

Function
for PARVB gene

Pathways & Interactions
for PARVB gene

Drugs & Compounds
for PARVB gene

Transcripts
for PARVB gene

Expression
for PARVB gene

Orthologs
for PARVB gene

Paralogs
for PARVB gene

Genomic Variants
for PARVB gene

Disorders / Diseases
for PARVB gene

Publications
for PARVB gene

Intellectual Property
for PARVB gene

Products
for PARVB gene