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Aliases for PARVA Gene

Aliases for PARVA Gene

  • Parvin Alpha 2 3 5
  • Calponin-Like Integrin-Linked Kinase-Binding Protein 3 4
  • Matrix-Remodeling-Associated Protein 2 3 4
  • Actopaxin 3 4
  • CH-ILKBP 3 4
  • MXRA2 3 4
  • Matrix-Remodelling Associated 2 2
  • Parvin, Alpha 3

External Ids for PARVA Gene

Previous HGNC Symbols for PARVA Gene

  • MXRA2

Previous GeneCards Identifiers for PARVA Gene

  • GC11P013670
  • GC11P013148
  • GC11P012438
  • GC11P012363
  • GC11P012355
  • GC11P012075

Summaries for PARVA Gene

Entrez Gene Summary for PARVA Gene

  • This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

GeneCards Summary for PARVA Gene

PARVA (Parvin Alpha) is a Protein Coding gene. Diseases associated with PARVA include adiaspiromycosis and breast giant fibroadenoma. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include actin binding. An important paralog of this gene is PARVB.

UniProtKB/Swiss-Prot for PARVA Gene

  • Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.

Gene Wiki entry for PARVA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARVA Gene

Genomics for PARVA Gene

Regulatory Elements for PARVA Gene

Promoters for PARVA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARVA on UCSC Golden Path with GeneCards custom track

Genomic Location for PARVA Gene

Chromosome:
11
Start:
12,376,441 bp from pter
End:
12,535,356 bp from pter
Size:
158,916 bases
Orientation:
Plus strand

Genomic View for PARVA Gene

Genes around PARVA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARVA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARVA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARVA Gene

Proteins for PARVA Gene

  • Protein details for PARVA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVD7-PARVA_HUMAN
    Recommended name:
    Alpha-parvin
    Protein Accession:
    Q9NVD7
    Secondary Accessions:
    • Q96C85
    • Q9HA48

    Protein attributes for PARVA Gene

    Size:
    372 amino acids
    Molecular mass:
    42244 Da
    Quaternary structure:
    • Interacts with TGFB1I1 (By similarity). Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with ARHGAP31. Interacts with the actin cytoskeleton.

    Three dimensional structures from OCA and Proteopedia for PARVA Gene

    Alternative splice isoforms for PARVA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARVA Gene

Proteomics data for PARVA Gene at MOPED

Post-translational modifications for PARVA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARVA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PARVA (PARVA)

No data available for DME Specific Peptides for PARVA Gene

Domains & Families for PARVA Gene

Gene Families for PARVA Gene

Protein Domains for PARVA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PARVA Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVD7

UniProtKB/Swiss-Prot:

PARVA_HUMAN :
  • Contains 2 CH (calponin-homology) domains.
  • Belongs to the parvin family.
Domain:
  • Contains 2 CH (calponin-homology) domains.
Family:
  • Belongs to the parvin family.
genes like me logo Genes that share domains with PARVA: view

Function for PARVA Gene

Molecular function for PARVA Gene

UniProtKB/Swiss-Prot Function:
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.
genes like me logo Genes that share phenotypes with PARVA: view

Animal Models for PARVA Gene

MGI Knock Outs for PARVA:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARVA Gene

Localization for PARVA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARVA Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARVA Gene COMPARTMENTS Subcellular localization image for PARVA gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 4
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PARVA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with PARVA: view

Pathways & Interactions for PARVA Gene

genes like me logo Genes that share pathways with PARVA: view

Gene Ontology (GO) - Biological Process for PARVA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003148 outflow tract septum morphogenesis IEA,ISS --
GO:0007155 cell adhesion IEA --
GO:0034446 substrate adhesion-dependent cell spreading IEA,IMP 11331308
GO:0060271 cilium morphogenesis IMP 20393563
GO:0070252 actin-mediated cell contraction IEA,ISS --
genes like me logo Genes that share ontologies with PARVA: view

No data available for SIGNOR curated interactions for PARVA Gene

Drugs & Compounds for PARVA Gene

(2) Drugs for PARVA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PARVA: view

Transcripts for PARVA Gene

Unigene Clusters for PARVA Gene

Parvin, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARVA Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - -
SP3:
SP4: - - - - - - -
SP5: - -
SP6: - - -
SP7: - - - - - -
SP8: -

Relevant External Links for PARVA Gene

GeneLoc Exon Structure for
PARVA
ECgene alternative splicing isoforms for
PARVA

Expression for PARVA Gene

mRNA expression in normal human tissues for PARVA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARVA Gene

This gene is overexpressed in Urinary Bladder (8.9), Seminal vesicle (8.8), Cardia (7.3), and Uterus (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARVA Gene



SOURCE GeneReport for Unigene cluster for PARVA Gene Hs.432914

mRNA Expression by UniProt/SwissProt for PARVA Gene

Q9NVD7-PARVA_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
genes like me logo Genes that share expression patterns with PARVA: view

Protein tissue co-expression partners for PARVA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PARVA Gene

Orthologs for PARVA Gene

This gene was present in the common ancestor of animals.

Orthologs for PARVA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARVA 36
  • 100 (a)
OneToOne
PARVA 35
  • 99.49 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PARVA 35
  • 93.88 (n)
  • 98.45 (a)
PARVA 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARVA 36
  • 96 (a)
OneToOne
PARVA 35
  • 92.72 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Parva 36
  • 98 (a)
OneToOne
Parva 16
Parva 35
  • 90.23 (n)
  • 98.39 (a)
oppossum
(Monodelphis domestica)
Mammalia PARVA 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARVA 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parva 35
  • 90.5 (n)
  • 98.66 (a)
chicken
(Gallus gallus)
Aves PARVA 35
  • 81.18 (n)
  • 97.31 (a)
PARVA 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARVA 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parva 35
  • 81.39 (n)
  • 94.16 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.703 35
zebrafish
(Danio rerio)
Actinopterygii parvaa 36
  • 91 (a)
OneToMany
parvab 36
  • 90 (a)
OneToMany
parvab 36
  • 90 (a)
OneToMany
parvaa 35
  • 78.49 (n)
  • 90.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32528 36
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pat-6 35
  • 53.97 (n)
  • 51.79 (a)
pat-6 37
  • 46 (a)
pat-6 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for PARVA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARVA Gene

ENSEMBL:
Gene Tree for PARVA (if available)
TreeFam:
Gene Tree for PARVA (if available)

Paralogs for PARVA Gene

Paralogs for PARVA Gene

(2) SIMAP similar genes for PARVA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PARVA: view

Variants for PARVA Gene

Sequence variations from dbSNP and Humsavar for PARVA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs16936 -- 12,445,234(+) GCTAA(C/G)TATAC intron-variant
rs7644 -- 12,530,297(+) TAGAA(C/T)CTGGA utr-variant-3-prime
rs7718 -- 12,528,214(+) ACCAG(C/G)TTAGG utr-variant-3-prime
rs867298 -- 12,516,363(+) TGTGC(A/G)TCTGA intron-variant
rs868992 -- 12,459,804(-) CTGCT(A/T)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARVA Gene

Variant ID Type Subtype PubMed ID
esv2624026 CNV Deletion 19546169
esv2411772 CNV Deletion 18987734
esv2670255 CNV Deletion 23128226
esv26204 CNV Loss 19812545
nsv896995 CNV Gain 21882294
nsv524625 CNV Loss 19592680
nsv519326 CNV Loss 19592680

Variation tolerance for PARVA Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARVA Gene

HapMap Linkage Disequilibrium report
PARVA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARVA Gene

Disorders for PARVA Gene

MalaCards: The human disease database

(4) MalaCards diseases for PARVA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adiaspiromycosis
breast giant fibroadenoma
  • giant fibroadenoma
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
lynch syndrome
  • coca 1
- elite association - COSMIC cancer census association via MalaCards
Search PARVA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PARVA

Genetic Association Database (GAD)
PARVA
Human Genome Epidemiology (HuGE) Navigator
PARVA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARVA
genes like me logo Genes that share disorders with PARVA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARVA Gene

Publications for PARVA Gene

  1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PMID: 11171322) Olski T.M. … Korenbaum E. (J. Cell Sci. 2001) 2 3 4 23 67
  2. Integrin-linked kinase: a multi-functional regulator modulating extracellular pressure-stimulated cancer cell adhesion through focal adhesion kinase and AKT. (PMID: 19633364) Wang S. … Basson M.D. (Cell. Oncol. 2009) 3 23
  3. The pseudoactive site of ILK is essential for its binding to alpha- parvin and localization to focal adhesions. (PMID: 20005845) Fukuda K. … Qin J. (Mol. Cell 2009) 3 23
  4. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. (PMID: 18508764) Wang X. … Qin J. (J. Biol. Chem. 2008) 3 23
  5. Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance. (PMID: 18722108) Papachristou D.J. … Papavassiliou A.G. (Eur. J. Cancer 2008) 3 23

Products for PARVA Gene

Sources for PARVA Gene

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