PARS2 Gene
protein-coding GIFtS: 55
GCID: GC01M055222
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|
prolyl-tRNA synthetase 2, mitochondrial (putative)
| |
Aliases
for PARS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Prolyl-TRNA Synthetase 2, Mitochondrial (Putative)1 2 | | Probable Proline--TRNA Ligase, Mitochondrial2 | | EC 6.1.1.153 8 | | Proline TRNA Ligase 2, Mitochondrial (Putative)2 | | DKFZp727A0711 | | Proline--TRNA Ligase2 | | MT-PRORS2 | | ProRS3 | | ProRS3 | | Prolyl-TRNA Synthetase3 |
Export aliases for PARS2 gene to outside databasesPrevious GC identifers: GC01M054935 GC01M054995 GC01M053336 |
Summaries
for PARS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PARS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PARS2 gene promoter:
GR GR-beta SREBP-1c Lmo2 Tal-1beta SREBP-1b AREB6 SREBP-1a GR-alpha ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PARS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.2 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.2PARS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M055222: view genomic region
(about GC identifiers)
Start:
|
55,222,571 bp from pter |
End:
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55,230,226 bp from pter |
Size:
|
7,656 bases |
Orientation:
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minus strand |
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Proteins
for PARS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYPM_HUMAN, Q7L3T8 (See
protein sequence)Recommended Name: Probable proline--tRNA ligase, mitochondrial precursor Size: 475 amino acids; 53263 Da
Subcellular location: Mitochondrion matrix (Potential)
Sequence caution: Sequence=BAB15178.1; Type=Erroneous initiation;
Secondary accessions: A8K0W4 Q9H6S5 Q9UFT1Explore the universe of human proteins at neXtProt for PARS2: NX_Q7L3T8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L3T8
4/5 DME Specific Peptides for PARS2 (Q7L3T8) (see all 5)
PARS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689481.2
ENSEMBL proteins: ENSP00000360327 Reactome Protein details: Q7L3T8
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005759 | mitochondrial matrix |
IEA | -- |
PARS2 for ontologies About GeneDecksing
PARS2 Antibody Products:
Assay Products for PARS2: |
Protein
Domains /
Families
for PARS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PARS2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L3T8ProtoNet protein and cluster: Q7L3T8 2 Blocks protein families: IPB002316 Prolyl-tRNA synthetase signature IPB004154 Anticodon binding domain
UniProtKB/Swiss-Prot: SYPM_HUMAN, Q7L3T8Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family |
Function
for PARS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SYPM_HUMAN, Q7L3T8Catalytic activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)Enzyme Number (IUBMB): EC 6.1.1.151 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PARS2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PARS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PARS2 (NM_152268) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PARS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARS2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004827 | proline-tRNA ligase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
PARS2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PARS2:
|
Pathways & Interactions
for PARS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | tRNA Aminoacylation | | | 2 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for PARS2
1 
Kegg Pathway (Kegg details for PARS2):
PARS2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PARS2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/254 Interacting proteins for PARS2 (Q7L3T82, 3 ENSP000003603274) via UniProtKB, MINT, STRING, and/or I2D (see all 254)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006418 | tRNA aminoacylation for protein translation |
TAS | -- | | GO:0006433 | prolyl-tRNA aminoacylation |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- |
PARS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PARS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PARS2 for compounds About GeneDecksing
 Browse Tocris compounds for PARS2
5 HMDB Compounds for PARS2 About this table
1 DrugBank Compound for PARS2 About this table
5 Novoseek chemical compound relationships for PARS2 gene About this table
Search CenterWatch for drugs/clinical trials and news about PARS2 / SYPM
|
Transcripts
for PARS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PARS2 gene: NM_152268.3 Unigene Cluster for PARS2: Prolyl-tRNA synthetase 2, mitochondrial (putative) Hs.380169 [show with all ESTs]Unigene Representative Sequence: NM_1522681 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000371279(uc001cxy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PARS2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PARS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PARS2 (NM_152268) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PARS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARS2 |
Additional cDNA sequence: AK025585.1 AK289679.1 AL117473.1 BC007956.2 BC011758.2 1 DOTS entry: DT.112977 24/62 AceView cDNA sequences (see all 62): AI760089 BQ883270 CB242529 AL117473 NM_152268 BC011758 BM682402 BM997509 AI240535 AW409848 BC007956 AI074384 AK025585 BM451210 BQ935346 BQ931648 CB306752 CR603986 BF342423 BQ923564 BM450984 BU680535 BG469980 BX110932
GeneLoc Exon Structure
|
Expression
for PARS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PARS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGGTGTGT
About this image
See PARS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PARS2
SOURCE GeneReport for Unigene cluster: Hs.380169
SABiosciences Custom PCR Arrays for PARS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PARS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PARS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARS2 |
Orthologs
for PARS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for PARS2 gene from 10/38 species (see all 38) About this table
ENSEMBL Gene Tree for PARS2 (if available)
TreeFam Gene Tree for PARS2 (if available) |
Paralogs
for PARS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PARS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PARS2 (55222571 - 55230226 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PARS2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PARS2 |
|
Disorders
/ Diseases
for PARS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PARS2 for disorders About GeneDecksing
OMIM gene information: 612036
OMIM disorders: --
4  diseases for PARS2: About MalaCardspneumonia tuberculosis malaria mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: PARS2 (1 document)
Export disorders for PARS2 gene to outside databases
|
Publications
for PARS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PARS2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with PARS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 3 Bonnefond L....Sissler M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for PARS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PARS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PARS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PARS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PARS2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PARS2 gene:
Search GeneIP for patents involving PARS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PARS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PARS2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PARS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PARS2 | | | OriGene Protein Over-expression Lysate for PARS2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PARS2 | | OriGene 3'-UTR Clone for PARS2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PARS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PARS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PARS2 | | OriGene Custom Protein Services for PARS2 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PARS2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PARS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARS2 |
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 |  |  |  | |
| | | | Search Tocris compounds for PARS2 |
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 | | | PARS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARS2 |
|  |  |  | | | | Search ThermoFisher Antibodies for PARS2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARS2 |
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