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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PARS2 Gene

protein-coding   GIFtS: 60
GCID: GC01M055222

Prolyl-TRNA Synthetase 2, Mitochondrial (Putative)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prolyl-TRNA Synthetase 2, Mitochondrial (Putative)1 2     Probable Proline--TRNA Ligase, Mitochondrial2
EC 6.1.1.153 8     Proline TRNA Ligase 2, Mitochondrial (Putative)2
Mitochondrial (Putative)1     Proline--TRNA Ligase2
Proline TRNA Ligase 21     ProRS3
MT-PRORS2     Prolyl-TRNA Synthetase3
proRS2     

External Ids:    HGNC: 305631   Entrez Gene: 259732   Ensembl: ENSG000001623967   OMIM: 6120365   UniProtKB: Q7L3T83   

Export aliases for PARS2 gene to outside databases

Previous GC identifers: GC01M054935 GC01M054995 GC01M053336


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PARS2 Gene: 
PARS2 (prolyl-tRNA synthetase 2, mitochondrial (putative)) is a protein-coding gene. Diseases associated with PARS2 include pneumonia, and tuberculosis, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include proline-tRNA ligase activity and ATP binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PARS2 gene promoter:
         GR   GR-beta   SREBP-1c   Lmo2   Tal-1beta   SREBP-1b   AREB6   SREBP-1a   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PARS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.2   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.2

PARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M055222:  view genomic region     (about GC identifiers)

Start:
55,222,571 bp from pter      End:
55,230,226 bp from pter
Size:
7,656 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYPM_HUMAN, Q7L3T8 (See protein sequence)
Recommended Name: Probable proline--tRNA ligase, mitochondrial precursor  
Size: 475 amino acids; 53263 Da
Subcellular location: Mitochondrion matrix (Potential)
Sequence caution: Sequence=BAB15178.1; Type=Erroneous initiation;
Secondary accessions: A8K0W4 Q9H6S5 Q9UFT1

Explore the universe of human proteins at neXtProt for PARS2: NX_Q7L3T8

Explore proteomics data for PARS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L3T8

  • 4/5 DME Specific Peptides for PARS2 (Q7L3T8) (see all 5)
     EVLLDDR  LGPTHEE  RPRFGLLR  GLLRGREF 

    PARS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PARS2 Protein Expression
    REFSEQ proteins: NP_689481.2  
    ENSEMBL proteins: 
     ENSP00000360327  
    Reactome Protein details: Q7L3T8
    Human Recombinant Protein Products for PARS2: 
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    OriGene Protein Over-expression Lysate for PARS2
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for PARS2
    Novus Biologicals PARS2 Protein
    Novus Biologicals PARS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PARS2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix IEA--

    PARS2 for ontologies           About GeneDecksing



    PARS2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for PARS2 
    Cloud-Clone Corp. CLIAs for PARS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS2: Aminoacyl tRNA synthetases / Class II

    5 InterPro protein domains:
     IPR002314 aa-tRNA-synt_IIb_cons-dom
     IPR004500 Pro-tRNA-synth_IIa_bac-type
     IPR006195 aa-tRNA-synth_II
     IPR004154 Anticodon-bd
     IPR002316 Pro-tRNA-ligase_IIa

    Graphical View of Domain Structure for InterPro Entry Q7L3T8

    ProtoNet protein and cluster: Q7L3T8

    2 Blocks protein domains:
    IPB002316 Prolyl-tRNA synthetase signature
    IPB004154 Anticodon binding domain


    UniProtKB/Swiss-Prot: SYPM_HUMAN, Q7L3T8
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family


    PARS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYPM_HUMAN, Q7L3T8
    Catalytic activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)

         Enzyme Number (IUBMB): EC 6.1.1.151 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004827proline-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    PARS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PARS2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PARS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PARS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARS2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARS2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PARS2:
    hsa-miR-4264 hsa-miR-516b hsa-miR-185 hsa-miR-4306
    SwitchGear 3'UTR luciferase reporter plasmidPARS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PARS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARS2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PARS2

    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARS2
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                         Customized lentivirus expression plasmids for stable overexpression of PARS2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PARS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.54
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for PARS2
        tRNA Aminoacylation
    Gene Expression
    Mitochondrial tRNA aminoacylation


    1         Kegg Pathway  (Kegg details for PARS2):
        Aminoacyl-tRNA biosynthesis


    PARS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/268 Interacting proteins for PARS2 (Q7L3T82, 3 ENSP000003603274) via UniProtKB, MINT, STRING, and/or I2D (see all 268)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    PRKAA2P546463, ENSP000003602904I2D: score=3 STRING: ENSP00000360290
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    ALDH18A1P548862, ENSP000003602684MINT-8079030 STRING: ENSP00000360268
    HSPD1P108092, ENSP000003400194MINT-8079030 STRING: ENSP00000340019
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006433prolyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    PARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PARS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PARS2 (SYPM)

    5 HMDB Compounds for PARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for PARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for PARS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(pro) 94.3 11 9478190 (3), 11112540 (2), 9622512 (1)
    aminoacyl-trna 86.7 2 12438642 (1), 16843487 (1)
    trna 76.6 12 11342535 (4), 18180290 (1), 11112540 (1), 18310681 (1) (see all 5)
    anticodon 72.8 6 11342535 (2), 9478190 (1)
    proline 56.6 1 9622512 (1)

    Search CenterWatch for drugs/clinical trials and news about PARS2 / SYPM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PARS2 gene: 
    NM_152268.3  

    Unigene Cluster for PARS2:

    Prolyl-tRNA synthetase 2, mitochondrial (putative)
    Hs.380169  [show with all ESTs]
    Unigene Representative Sequence: NM_152268
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371279(uc001cxy.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARS2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PARS2:
    hsa-miR-4264 hsa-miR-516b hsa-miR-185 hsa-miR-4306
    SwitchGear 3'UTR luciferase reporter plasmidPARS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PARS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARS2
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    OriGene clones in human, mouse for PARS2 (see all 8)
    OriGene ORF clones in mouse, rat for PARS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARS2 (NM_152268)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARS2
    Sirion Biotech Customized lentivirus for stable overexpression of PARS2 
                         Customized lentivirus expression plasmids for stable overexpression of PARS2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PARS2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARS2

    Additional mRNA sequence: 

    AK025585.1 AK289679.1 AL117473.1 BC007956.2 BC011758.2 

    1 DOTS entry:

    DT.112977 

    24/62 AceView cDNA sequences (see all 62):

    AK025585 NM_152268 CB242529 BC007956 BM451210 AL117473 BM997509 BQ883270 
    BC011758 AW409848 BM682402 AI240535 BQ935346 CB306752 AI074384 BQ931648 
    CR603986 AI760089 BX401825 BE269729 BE888055 AW005812 BG469980 BM450984 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGTGTGT
    PARS2 Expression
    About this image


    See PARS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PARS2

    SOURCE GeneReport for Unigene cluster: Hs.380169
        SABiosciences Custom PCR Arrays for PARS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PARS2 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pars21 , 5 prolyl-tRNA synthetase (mitochondrial)(putative)1, 5 83.16(n)1
    81.89(a)1
      4 (49.67 cM)5
    2305771  NM_001083887.11  NP_001077356.11 
     1066510695 
    chicken
    (Gallus gallus)
    Aves PARS21 prolyl-tRNA synthetase 2, mitochondrial (putative) 68.35(n)
    66.67(a)
      424659  XM_422493.1  XP_422493.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARS26
    Uncharacterized protein
    64(a)
    1 ↔ 1
    4(104460292-104461710)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044273.12   -- 73.69(n)    BC044273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM861624.12   -- 73.47(n)    BM861624.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-pro1 Prolyl-tRNA synthetase 52.45(n)
    46.13(a)
      38331  NM_139480.2  NP_647737.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pars-21 Protein PARS-2 48.33(n)
    42.12(a)
      173117  NM_001047224.2  NP_001040689.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AIM10(YER087W)4
    AIM101
    Protein with similarity to tRNA synthetases; non-tagged more4
    Aim10p1
    47.57(n)1
    40.05(a)1
      5(330576-332306)4
    8568201, 4  NP_011010.11, 4 


    ENSEMBL Gene Tree for PARS2 (if available)
    TreeFam Gene Tree for PARS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/263 SNPs in PARS2 are shown (see all 263)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922488951,2
    --55222074(+) CTTTTC/TAGGAG 1 -- int10--------
    rs27648221,2
    C,F,A,H--55222080(+) AGGAGG/ATGCTG 1 -- int127Minor allele frequency- A:0.26NS EA NA WA CSA 2526
    rs1156307601,2
    F--55222103(+) GTCTTC/TACAGA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1834456171,2
    --55222112(+) GATTCC/TTGTCA 1 -- int10--------
    rs27648231,2
    C,F,A,H--55222130(+) ACATGT/CAGAGA 1 -- int113Minor allele frequency- C:0.29NA WA CSA EA 378
    rs752490211,2
    --55222150(+) GCCAAC/GGATGG 1 -- int10--------
    rs1388624491,2
    C--55222318(+) CCAGCA/TCTTAA 1 -- int10--------
    rs353663951,2
    C,F--55222401(+) TGCCCC/TGATAC 1 -- int16Minor allele frequency- T:0.31NA WA EA 364
    rs1438949701,2
    --55222409(+) TACTT-/GGGGGA 1 -- int10--------
    rs19256591,2
    C,F,A,H--55222466(-) ACCCAC/TCCCTA 1 -- int124Minor allele frequency- T:0.26NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for PARS2 (55222571 - 55230226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PARS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871008CNV Loss21882294
    nsv817614CNV Gain22305530
    nsv461561CNV Gain19166990
    nsv461594CNV Gain19166990
    dgv229n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612036    OMIM disorders: --

    2 diseases for PARS2:    About MalaCards
    pneumonia    tuberculosis


    PARS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PARS2
    Human Genome Epidemiology (HuGE) Navigator: PARS2 (1 document)

    Export disorders for PARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARS2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with PARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 3 Bonnefond L....Sissler M. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. ATP-directed capture of bioactive herbal-based medicin e on human tRNA synthetase. (PubMed id 23263184)1 Zhou H....Schimmel P. (2013)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25973 HGNC: 30563 AceView: DKFZp727A071 Ensembl:ENSG00000162396 euGenes: HUgn25973
    ECgene: PARS2 Kegg: 25973 H-InvDB: PARS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PARS2 gene:
    Search GeneIP for patents involving PARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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