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Aliases for PARPBP Gene

Aliases for PARPBP Gene

  • PARP1 Binding Protein 2 3 5
  • PARP-1 Binding Protein 2 4
  • C12orf48 3 4
  • PARI 3 4
  • Chromosome 12 Open Reading Frame 48 2
  • PARP1-Binding Protein 4
  • AROM 3

External Ids for PARPBP Gene

Previous HGNC Symbols for PARPBP Gene

  • C12orf48

Previous GeneCards Identifiers for PARPBP Gene

  • GC12P102514

Summaries for PARPBP Gene

GeneCards Summary for PARPBP Gene

PARPBP (PARP1 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PARPBP Gene

  • Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARPBP Gene

Genomics for PARPBP Gene

Regulatory Elements for PARPBP Gene

Enhancers for PARPBP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PARPBP on UCSC Golden Path with GeneCards custom track

Promoters for PARPBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARPBP on UCSC Golden Path with GeneCards custom track

Genomic Location for PARPBP Gene

Chromosome:
12
Start:
102,120,171 bp from pter
End:
102,197,520 bp from pter
Size:
77,350 bases
Orientation:
Plus strand

Genomic View for PARPBP Gene

Genes around PARPBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARPBP Gene

Proteins for PARPBP Gene

  • Protein details for PARPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS1-PARI_HUMAN
    Recommended name:
    PCNA-interacting partner
    Protein Accession:
    Q9NWS1
    Secondary Accessions:
    • B4E0Y0
    • Q05C00
    • Q499L8
    • Q4FZA0
    • Q4KMW7
    • Q6NSC6
    • Q6PJA1
    • Q86W36

    Protein attributes for PARPBP Gene

    Size:
    579 amino acids
    Molecular mass:
    65054 Da
    Quaternary structure:
    • Interacts with RAD51 and PCNA. Interacts with PARP1.
    SequenceCaution:
    • Sequence=AAH18903.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH30962.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH50696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70270.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARPBP Gene

neXtProt entry for PARPBP Gene

Proteomics data for PARPBP Gene at MOPED

Post-translational modifications for PARPBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PARPBP Gene

Domains & Families for PARPBP Gene

Protein Domains for PARPBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARPBP Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWS1

UniProtKB/Swiss-Prot:

PARI_HUMAN :
  • Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.
  • Belongs to the PARI family.
Domain:
  • Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.
Family:
  • Belongs to the PARI family.
genes like me logo Genes that share domains with PARPBP: view

No data available for Gene Families for PARPBP Gene

Function for PARPBP Gene

Molecular function for PARPBP Gene

UniProtKB/Swiss-Prot Function:
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.
genes like me logo Genes that share phenotypes with PARPBP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PARPBP Gene

Localization for PARPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARPBP Gene

Cytoplasm. Nucleus. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARPBP Gene COMPARTMENTS Subcellular localization image for PARPBP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PARPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PARPBP: view

Pathways & Interactions for PARPBP Gene

SuperPathways for PARPBP Gene

No Data Available

Interacting Proteins for PARPBP Gene

Gene Ontology (GO) - Biological Process for PARPBP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PARPBP Gene

Drugs & Compounds for PARPBP Gene

No Compound Related Data Available

Transcripts for PARPBP Gene

Unigene Clusters for PARPBP Gene

PARP1 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARPBP Gene

No ASD Table

Relevant External Links for PARPBP Gene

GeneLoc Exon Structure for
PARPBP
ECgene alternative splicing isoforms for
PARPBP

Expression for PARPBP Gene

mRNA expression in normal human tissues for PARPBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARPBP Gene

This gene is overexpressed in Ovary (29.5), Testis (20.7), Prostate (8.7), and Fetal heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARPBP Gene



SOURCE GeneReport for Unigene cluster for PARPBP Gene Hs.330663

mRNA Expression by UniProt/SwissProt for PARPBP Gene

Q9NWS1-PARI_HUMAN
Tissue specificity: Restricted to testis. Overexpressed in multiple cancer cells.
genes like me logo Genes that share expression patterns with PARPBP: view

Protein tissue co-expression partners for PARPBP Gene

Primer Products

No data available for mRNA differential expression in normal tissues for PARPBP Gene

Orthologs for PARPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARPBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARPBP 35
  • 89.29 (n)
  • 84.63 (a)
PARPBP 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARPBP 35
  • 88.41 (n)
  • 82.53 (a)
PARPBP 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parpbp 35
  • 78.96 (n)
  • 70.28 (a)
Parpbp 16
Parpbp 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARPBP 35
  • 98.96 (n)
  • 98.62 (a)
PARPBP 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parpbp 35
  • 76.26 (n)
  • 66.94 (a)
oppossum
(Monodelphis domestica)
Mammalia PARPBP 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARPBP 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF48 35
  • 66.49 (n)
  • 55.77 (a)
PARPBP 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARPBP 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parpbp 35
  • 61.16 (n)
  • 53.86 (a)
zebrafish
(Danio rerio)
Actinopterygii parpbp 35
  • 51.53 (n)
  • 43.45 (a)
parpbp 36
  • 40 (a)
OneToOne
Species with no ortholog for PARPBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARPBP Gene

ENSEMBL:
Gene Tree for PARPBP (if available)
TreeFam:
Gene Tree for PARPBP (if available)

Paralogs for PARPBP Gene

No data available for Paralogs for PARPBP Gene

Variants for PARPBP Gene

Sequence variations from dbSNP and Humsavar for PARPBP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12227879 - 102,182,562(+) CACAG(A/G)TGAAT intron-variant, reference, missense
rs1980002 -- 102,181,882(-) AAAAT(A/C)TAATC intron-variant
rs2002134 -- 102,143,297(+) AGGAT(A/T)TAATC intron-variant
rs2036771 -- 102,124,026(-) TTCTC(C/T)GCCAT intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs2036772 -- 102,123,975(-) AGAGT(A/G)GTTCT intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Variation tolerance for PARPBP Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PARPBP Gene

Disorders for PARPBP Gene

Relevant External Links for PARPBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARPBP

No disorders were found for PARPBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARPBP Gene

Publications for PARPBP Gene

  1. C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. (PMID: 20931645) Piao L. … Nakamura Y. (Genes Chromosomes Cancer 2011) 2 3 4 67
  2. PARI overexpression promotes genomic instability and pancreatic tumorigenesis. (PMID: 23436799) O'Connor K.W. … Moldovan G.L. (Cancer Res. 2013) 3
  3. Meta-analysis of the cell cycle related C12orf48. (PMID: 24396997) Varisli L. (Biocell 2013) 3
  4. Inhibition of homologous recombination by the PCNA-interacting protein PARI. (PMID: 22153967) Moldovan G.L. … D'Andrea A.D. (Mol. Cell 2012) 3
  5. GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases. (PMID: 23039964) van Dam S. … de MagalhALes J.P. (BMC Genomics 2012) 3

Products for PARPBP Gene

Sources for PARPBP Gene

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