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Aliases for PARPBP Gene

Aliases for PARPBP Gene

  • PARP1 Binding Protein 2 3 5
  • PARP-1 Binding Protein 2 4
  • C12orf48 3 4
  • PARI 3 4
  • Chromosome 12 Open Reading Frame 48 2
  • PCNA-Interacting Partner 3
  • PARP1-Binding Protein 4
  • AROM 3

External Ids for PARPBP Gene

Previous HGNC Symbols for PARPBP Gene

  • C12orf48

Previous GeneCards Identifiers for PARPBP Gene

  • GC12P102514

Summaries for PARPBP Gene

GeneCards Summary for PARPBP Gene

PARPBP (PARP1 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PARPBP Gene

  • Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARPBP Gene

Genomics for PARPBP Gene

Regulatory Elements for PARPBP Gene

Enhancers for PARPBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G102118 1.1 ENCODE 10.4 +0.4 366 3.3 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF207 WASHC3 PMCH PARPBP ENSG00000257222 HELLPAR
GH12G102060 1.1 ENCODE 4.8 -58.5 -58497 2.1 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 WASHC3 UTP20 NUP37 ENSG00000257222 ST13P22 PARPBP NENFP2
GH12G102415 0.9 dbSUPER 4.3 +296.3 296280 1.6 RAD21 RARA YY1 CEBPB NFYC PPARG NR2F2 CEBPA ETV4 NR2C1 WASHC3 IGF1 PARPBP GC12M102404 GC12M102374
GH12G101234 0.5 dbSUPER 4.4 -884.2 -884160 2.7 CTCF RNF2 ZNF24 SLC5A8 PARPBP RPS6P19 UTP20
GH12G102182 0.5 ENCODE 0.2 +62.7 62666 1.4 GATA2 JUN FOS HELLPAR PARPBP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARPBP on UCSC Golden Path with GeneCards custom track

Promoters for PARPBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056353 129 2201 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CBX5 ZNF143 FOS

Genomic Location for PARPBP Gene

Chromosome:
12
Start:
102,120,171 bp from pter
End:
102,197,520 bp from pter
Size:
77,350 bases
Orientation:
Plus strand

Genomic View for PARPBP Gene

Genes around PARPBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARPBP Gene

Proteins for PARPBP Gene

  • Protein details for PARPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS1-PARI_HUMAN
    Recommended name:
    PCNA-interacting partner
    Protein Accession:
    Q9NWS1
    Secondary Accessions:
    • B4E0Y0
    • Q05C00
    • Q499L8
    • Q4FZA0
    • Q4KMW7
    • Q6NSC6
    • Q6PJA1
    • Q86W36

    Protein attributes for PARPBP Gene

    Size:
    579 amino acids
    Molecular mass:
    65054 Da
    Quaternary structure:
    • Interacts with RAD51 and PCNA. Interacts with PARP1.
    SequenceCaution:
    • Sequence=AAH18903.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH30962.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH50696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70270.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARPBP Gene

neXtProt entry for PARPBP Gene

Post-translational modifications for PARPBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PARPBP Gene

Domains & Families for PARPBP Gene

Protein Domains for PARPBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARPBP Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWS1

UniProtKB/Swiss-Prot:

PARI_HUMAN :
  • Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.
  • Belongs to the PARI family.
Domain:
  • Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.
Family:
  • Belongs to the PARI family.
genes like me logo Genes that share domains with PARPBP: view

No data available for Gene Families for PARPBP Gene

Function for PARPBP Gene

Molecular function for PARPBP Gene

UniProtKB/Swiss-Prot Function:
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

Gene Ontology (GO) - Molecular Function for PARPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22153967
genes like me logo Genes that share ontologies with PARPBP: view
genes like me logo Genes that share phenotypes with PARPBP: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PARPBP Gene

Localization for PARPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARPBP Gene

Cytoplasm. Nucleus. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARPBP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PARPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 22153967
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PARPBP: view

Pathways & Interactions for PARPBP Gene

SuperPathways for PARPBP Gene

No Data Available

Interacting Proteins for PARPBP Gene

Gene Ontology (GO) - Biological Process for PARPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:2000042 negative regulation of double-strand break repair via homologous recombination IMP 22153967
genes like me logo Genes that share ontologies with PARPBP: view

No data available for Pathways by source and SIGNOR curated interactions for PARPBP Gene

Drugs & Compounds for PARPBP Gene

No Compound Related Data Available

Transcripts for PARPBP Gene

Unigene Clusters for PARPBP Gene

PARP1 binding protein:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARPBP Gene

No ASD Table

Relevant External Links for PARPBP Gene

GeneLoc Exon Structure for
PARPBP
ECgene alternative splicing isoforms for
PARPBP

Expression for PARPBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARPBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARPBP Gene

This gene is overexpressed in Ovary (29.5), Testis (20.7), Prostate (8.7), and Fetal heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARPBP Gene



Protein tissue co-expression partners for PARPBP Gene

NURSA nuclear receptor signaling pathways regulating expression of PARPBP Gene:

PARPBP

SOURCE GeneReport for Unigene cluster for PARPBP Gene:

Hs.330663

mRNA Expression by UniProt/SwissProt for PARPBP Gene:

Q9NWS1-PARI_HUMAN
Tissue specificity: Restricted to testis. Overexpressed in multiple cancer cells.

Evidence on tissue expression from TISSUES for PARPBP Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with PARPBP: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARPBP Gene

Orthologs for PARPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARPBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARPBP 34 35
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia PARPBP 34 35
  • 89.29 (n)
dog
(Canis familiaris)
Mammalia PARPBP 34 35
  • 88.41 (n)
mouse
(Mus musculus)
Mammalia Parpbp 34 16 35
  • 78.96 (n)
rat
(Rattus norvegicus)
Mammalia Parpbp 34
  • 76.26 (n)
oppossum
(Monodelphis domestica)
Mammalia PARPBP 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARPBP 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF48 34
  • 66.49 (n)
PARPBP 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARPBP 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parpbp 34
  • 61.16 (n)
zebrafish
(Danio rerio)
Actinopterygii parpbp 34 35
  • 51.53 (n)
Species where no ortholog for PARPBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARPBP Gene

ENSEMBL:
Gene Tree for PARPBP (if available)
TreeFam:
Gene Tree for PARPBP (if available)

Paralogs for PARPBP Gene

No data available for Paralogs for PARPBP Gene

Variants for PARPBP Gene

Sequence variations from dbSNP and Humsavar for PARPBP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000003553 -- 102,144,365(+) ATTTT(A/G)AACTT intron-variant
rs1000033222 -- 102,185,716(+) TACAG(C/T)GGCGT intron-variant
rs1000056660 -- 102,189,414(+) AGGTC(C/T)TAGTC intron-variant
rs1000169838 -- 102,130,211(+) CCGGA(C/T)CTCTT intron-variant
rs1000226041 -- 102,172,526(+) AATGG(C/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARPBP Gene

Variant ID Type Subtype PubMed ID
esv3306658 CNV mobile element insertion 20981092
esv3309681 CNV mobile element insertion 20981092
esv3358325 CNV insertion 20981092
esv3382474 CNV insertion 20981092
nsv455702 CNV loss 19166990
nsv560032 CNV loss 21841781
nsv560033 CNV loss 21841781

Variation tolerance for PARPBP Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARPBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARPBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARPBP Gene

Disorders for PARPBP Gene

Relevant External Links for PARPBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARPBP

No disorders were found for PARPBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARPBP Gene

Publications for PARPBP Gene

  1. C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. (PMID: 20931645) Piao L. … Nakamura Y. (Genes Chromosomes Cancer 2011) 2 3 4 64
  2. Inhibition of homologous recombination by the PCNA-interacting protein PARI. (PMID: 22153967) Moldovan G.L. … D'Andrea A.D. (Mol. Cell 2012) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis. (PMID: 26792895) Burkovics P. … Krejci L. (Nucleic Acids Res. 2016) 3 64

Products for PARPBP Gene

Sources for PARPBP Gene

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