Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PARPBP Gene

Aliases for PARPBP Gene

  • PARP1 Binding Protein 2 3 5
  • PARP-1 Binding Protein 2 4
  • C12orf48 3 4
  • PARI 3 4
  • Chromosome 12 Open Reading Frame 48 2
  • PCNA-Interacting Partner 3
  • PARP1-Binding Protein 4
  • AROM 3

External Ids for PARPBP Gene

Previous HGNC Symbols for PARPBP Gene

  • C12orf48

Previous GeneCards Identifiers for PARPBP Gene

  • GC12P102514

Summaries for PARPBP Gene

GeneCards Summary for PARPBP Gene

PARPBP (PARP1 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PARPBP Gene

  • Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

Additional gene information for PARPBP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARPBP Gene

Genomics for PARPBP Gene

GeneHancer (GH) Regulatory Elements for PARPBP Gene

Promoters and enhancers for PARPBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I102118 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.5 +0.4 366 3.3 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B CBX5 NUP37 PARPBP WASHC3 ENSG00000257222 PMCH HELLPAR
GH12I102119 Promoter 0.5 EPDnew 550.8 -1.5 -1549 0.1 NUP37 PARPBP ENSG00000257222
GH12I101875 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 9.8 -242.8 -242823 4.5 HDGF ARNT ARID4B SIN3A DMAP1 POLR2B ZNF207 ZNF143 ZNF263 SP3 DRAM1 ENSG00000257222 CHPT1 UTP20 PARPBP GNPTAB PIR46358
GH12I102060 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.8 -58.5 -58496 2.1 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 WASHC3 ENSG00000257222 UTP20 NUP37 PARPBP NENFP2
GH12I102415 Enhancer 0.8 dbSUPER 4.4 +296.3 296279 1.6 FOXA2 RAD21 RARA YY1 RXRA CEBPB NFYC REST PPARG NR2F2 WASHC3 IGF1 PARPBP GC12M102404 GC12M102374 LINC02456
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PARPBP on UCSC Golden Path with GeneCards custom track

Genomic Locations for PARPBP Gene

Genomic Locations for PARPBP Gene
chr12:102,120,171-102,197,520
(GRCh38/hg38)
Size:
77,350 bases
Orientation:
Plus strand
chr12:102,513,956-102,591,298
(GRCh37/hg19)

Genomic View for PARPBP Gene

Genes around PARPBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARPBP Gene

Proteins for PARPBP Gene

  • Protein details for PARPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS1-PARI_HUMAN
    Recommended name:
    PCNA-interacting partner
    Protein Accession:
    Q9NWS1
    Secondary Accessions:
    • B4E0Y0
    • Q05C00
    • Q499L8
    • Q4FZA0
    • Q4KMW7
    • Q6NSC6
    • Q6PJA1
    • Q86W36

    Protein attributes for PARPBP Gene

    Size:
    579 amino acids
    Molecular mass:
    65054 Da
    Quaternary structure:
    • Interacts with RAD51 and PCNA. Interacts with PARP1.
    SequenceCaution:
    • Sequence=AAH18903.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH30962.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH50696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70270.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARPBP Gene

neXtProt entry for PARPBP Gene

Post-translational modifications for PARPBP Gene

No Post-translational modifications

No data available for DME Specific Peptides for PARPBP Gene

Domains & Families for PARPBP Gene

Gene Families for PARPBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PARPBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARPBP Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWS1

UniProtKB/Swiss-Prot:

PARI_HUMAN :
  • Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.
  • Belongs to the PARI family.
Domain:
  • Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.
Family:
  • Belongs to the PARI family.
genes like me logo Genes that share domains with PARPBP: view

Function for PARPBP Gene

Molecular function for PARPBP Gene

UniProtKB/Swiss-Prot Function:
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

Phenotypes From GWAS Catalog for PARPBP Gene

Gene Ontology (GO) - Molecular Function for PARPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22153967
genes like me logo Genes that share ontologies with PARPBP: view
genes like me logo Genes that share phenotypes with PARPBP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PARPBP Gene

Localization for PARPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARPBP Gene

Cytoplasm. Nucleus. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARPBP gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 22153967
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PARPBP: view

Pathways & Interactions for PARPBP Gene

SuperPathways for PARPBP Gene

No Data Available

Interacting Proteins for PARPBP Gene

Gene Ontology (GO) - Biological Process for PARPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:2000042 negative regulation of double-strand break repair via homologous recombination IMP 22153967
genes like me logo Genes that share ontologies with PARPBP: view

No data available for Pathways by source and SIGNOR curated interactions for PARPBP Gene

Drugs & Compounds for PARPBP Gene

No Compound Related Data Available

Transcripts for PARPBP Gene

Unigene Clusters for PARPBP Gene

PARP1 binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARPBP Gene

No ASD Table

Relevant External Links for PARPBP Gene

GeneLoc Exon Structure for
PARPBP
ECgene alternative splicing isoforms for
PARPBP

Expression for PARPBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARPBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARPBP Gene

This gene is overexpressed in Ovary (29.5), Testis (20.7), Prostate (8.7), and Fetal heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARPBP Gene



Protein tissue co-expression partners for PARPBP Gene

NURSA nuclear receptor signaling pathways regulating expression of PARPBP Gene:

PARPBP

SOURCE GeneReport for Unigene cluster for PARPBP Gene:

Hs.330663

mRNA Expression by UniProt/SwissProt for PARPBP Gene:

Q9NWS1-PARI_HUMAN
Tissue specificity: Restricted to testis. Overexpressed in multiple cancer cells.

Evidence on tissue expression from TISSUES for PARPBP Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with PARPBP: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARPBP Gene

Orthologs for PARPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARPBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARPBP 33 34
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia PARPBP 33 34
  • 89.29 (n)
dog
(Canis familiaris)
Mammalia PARPBP 33 34
  • 88.41 (n)
mouse
(Mus musculus)
Mammalia Parpbp 33 16 34
  • 78.96 (n)
rat
(Rattus norvegicus)
Mammalia Parpbp 33
  • 76.26 (n)
oppossum
(Monodelphis domestica)
Mammalia PARPBP 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARPBP 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF48 33
  • 66.49 (n)
PARPBP 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARPBP 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parpbp 33
  • 61.16 (n)
zebrafish
(Danio rerio)
Actinopterygii parpbp 33 34
  • 51.53 (n)
Species where no ortholog for PARPBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARPBP Gene

ENSEMBL:
Gene Tree for PARPBP (if available)
TreeFam:
Gene Tree for PARPBP (if available)

Paralogs for PARPBP Gene

No data available for Paralogs for PARPBP Gene

Variants for PARPBP Gene

Sequence variations from dbSNP and Humsavar for PARPBP Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000003553 -- 102,144,365(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000033222 -- 102,185,716(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000056660 -- 102,189,414(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000169838 -- 102,130,211(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000226041 -- 102,172,526(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PARPBP Gene

Variant ID Type Subtype PubMed ID
esv3306658 CNV mobile element insertion 20981092
esv3309681 CNV mobile element insertion 20981092
esv3358325 CNV insertion 20981092
esv3382474 CNV insertion 20981092
nsv455702 CNV loss 19166990
nsv560032 CNV loss 21841781
nsv560033 CNV loss 21841781

Variation tolerance for PARPBP Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARPBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARPBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARPBP Gene

Disorders for PARPBP Gene

Additional Disease Information for PARPBP

No disorders were found for PARPBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARPBP Gene

Publications for PARPBP Gene

  1. C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. (PMID: 20931645) Piao L … Nakamura Y (Genes, chromosomes & cancer 2011) 2 3 4 58
  2. Inhibition of homologous recombination by the PCNA-interacting protein PARI. (PMID: 22153967) Moldovan GL … D'Andrea AD (Molecular cell 2012) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. (PMID: 28894029) Mochizuki AL … Chuma S (Molecular and cellular biology 2017) 3 58

Products for PARPBP Gene

Sources for PARPBP Gene

Content
Loading form....