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Aliases for PARP9 Gene

Aliases for PARP9 Gene

  • Poly (ADP-Ribose) Polymerase Family, Member 9 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 9 3 4
  • B Aggressive Lymphoma Protein 3 4
  • PARP-9 3 4
  • ARTD9 3 4
  • BAL1 3 4
  • BAL 3 4
  • Poly (ADP-Ribose) Polymerase 9 3
  • EC 2.4.2.30 4
  • MGC:7868 3

External Ids for PARP9 Gene

Previous GeneCards Identifiers for PARP9 Gene

  • GC03M123729
  • GC03M122246
  • GC03M119620

Summaries for PARP9 Gene

GeneCards Summary for PARP9 Gene

PARP9 (Poly (ADP-Ribose) Polymerase Family, Member 9) is a Protein Coding gene. Diseases associated with PARP9 include b-cell lymphomas and diffuse large b-cell lymphoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and all-trans-Retinoic Acid Mediated Apoptosis. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP9 Gene

  • In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.

Tocris Summary for PARP9 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP9 Gene

Genomics for PARP9 Gene

Regulatory Elements for PARP9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PARP9 Gene

Chromosome:
3
Start:
122,527,910 bp from pter
End:
122,564,676 bp from pter
Size:
36,767 bases
Orientation:
Minus strand

Genomic View for PARP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP9 Gene

Proteins for PARP9 Gene

  • Protein details for PARP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXQ6-PARP9_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 9
    Protein Accession:
    Q8IXQ6
    Secondary Accessions:
    • A8KA94
    • B2R8S9
    • E9PFM7
    • Q8TCP3
    • Q9BZL8
    • Q9BZL9

    Protein attributes for PARP9 Gene

    Size:
    854 amino acids
    Molecular mass:
    96343 Da
    Quaternary structure:
    • Interacts with DTX3L. Interacts with PARP1 (when poly-ADP-ribosylated).

    Three dimensional structures from OCA and Proteopedia for PARP9 Gene

    Alternative splice isoforms for PARP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP9 Gene

Proteomics data for PARP9 Gene at MOPED

Post-translational modifications for PARP9 Gene

  • Ubiquitination at Lys 477, Lys 632, and Lys 740
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PARP9 Gene

Domains & Families for PARP9 Gene

Gene Families for PARP9 Gene

Protein Domains for PARP9 Gene

Suggested Antigen Peptide Sequences for PARP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXQ6

UniProtKB/Swiss-Prot:

PARP9_HUMAN :
  • The domain macro 2 is required for recruitment to DNA damage sites.
Domain:
  • The domain macro 2 is required for recruitment to DNA damage sites.
  • Contains 2 Macro domains.
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP9: view

Function for PARP9 Gene

Molecular function for PARP9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFN-gamma in B-cell lymphoma cell lines.

Enzyme Numbers (IUBMB) for PARP9 Gene

Gene Ontology (GO) - Molecular Function for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA 23230272
GO:0005515 protein binding IPI 16809771
genes like me logo Genes that share ontologies with PARP9: view
genes like me logo Genes that share phenotypes with PARP9: view

Animal Model Products

miRNA for PARP9 Gene

miRTarBase miRNAs that target PARP9

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PARP9 Gene

Localization for PARP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP9 Gene

Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP9 Gene COMPARTMENTS Subcellular localization image for PARP9 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 11110709
GO:0005737 cytoplasm IDA 16809771
GO:0005829 cytosol IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PARP9: view

Pathways & Interactions for PARP9 Gene

genes like me logo Genes that share pathways with PARP9: view

Gene Ontology (GO) - Biological Process for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IMP 23230272
GO:0008152 metabolic process --
GO:0016477 cell migration TAS 11110709
GO:0060330 regulation of response to interferon-gamma IDA 16809771
genes like me logo Genes that share ontologies with PARP9: view

No data available for SIGNOR curated interactions for PARP9 Gene

Drugs & Compounds for PARP9 Gene

(3) Drugs for PARP9 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 332,340
NU1025 Experimental Pharma Potent PARP inhibitor 0
NAD Pharma Agonist, Activator 0

(4) Additional Compounds for PARP9 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7
genes like me logo Genes that share compounds with PARP9: view

Transcripts for PARP9 Gene

Unigene Clusters for PARP9 Gene

Poly (ADP-ribose) polymerase family, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for PARP9 Gene

GeneLoc Exon Structure for
PARP9
ECgene alternative splicing isoforms for
PARP9

Expression for PARP9 Gene

mRNA expression in normal human tissues for PARP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP9 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for PARP9 Gene

This gene is overexpressed in Lymph node (20.6), Spleen (6.9), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP9 Gene



SOURCE GeneReport for Unigene cluster for PARP9 Gene Hs.518200

mRNA Expression by UniProt/SwissProt for PARP9 Gene

Q8IXQ6-PARP9_HUMAN
Tissue specificity: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells.
genes like me logo Genes that share expression patterns with PARP9: view

Protein tissue co-expression partners for PARP9 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PARP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARP9 35
  • 79.07 (n)
  • 65.76 (a)
PARP9 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP9 35
  • 78.28 (n)
  • 66.99 (a)
PARP9 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp9 35
  • 74.19 (n)
  • 62.82 (a)
Parp9 16
Parp9 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARP9 35
  • 99.35 (n)
  • 98.66 (a)
PARP9 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp9 35
  • 73.18 (n)
  • 61.79 (a)
oppossum
(Monodelphis domestica)
Mammalia PARP9 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP9 35
  • 51.99 (n)
  • 40.83 (a)
PARP9 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP9 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp9 35
  • 47.11 (n)
  • 38.47 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-219a4.6 35
  • 50.02 (n)
  • 38.81 (a)
PARP9 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for PARP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP9 Gene

ENSEMBL:
Gene Tree for PARP9 (if available)
TreeFam:
Gene Tree for PARP9 (if available)

Paralogs for PARP9 Gene

Paralogs for PARP9 Gene

(2) SIMAP similar genes for PARP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PARP9: view

Variants for PARP9 Gene

Sequence variations from dbSNP and Humsavar for PARP9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1500530 -- 122,556,625(+) agtag(G/T)ttatt intron-variant
rs1979853 -- 122,550,533(-) ATTCA(C/T)TCAGC intron-variant
rs2133851 -- 122,556,949(+) gtagc(C/T)agggc intron-variant
rs2270859 -- 122,536,861(-) AAAAG(C/T)TCACC intron-variant
rs3052711 -- 122,557,324(+) ATGAG(-/TGGAG)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP9 Gene

Variant ID Type Subtype PubMed ID
nsv877391 CNV Gain 21882294

Variation tolerance for PARP9 Gene

Residual Variation Intolerance Score: 45.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP9 Gene

HapMap Linkage Disequilibrium report
PARP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP9 Gene

Disorders for PARP9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PARP9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphomas
  • b-cell lymphoma
diffuse large b-cell lymphoma
  • large b cell diffuse lymphoma
- elite association
Search PARP9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PARP9_HUMAN
  • Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.

Relevant External Links for PARP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP9
genes like me logo Genes that share disorders with PARP9: view

No data available for Genatlas for PARP9 Gene

Publications for PARP9 Gene

  1. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q. … Shipp M.A. (Mol. Cell 2009) 23 67
  2. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. (PMID: 16809771) Juszczynski P. … Shipp M.A. (Mol. Cell. Biol. 2006) 23 67
  3. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PMID: 16061477) Aguiar R.C.T. … Shipp M.A. (J. Biol. Chem. 2005) 23 67
  4. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. (PMID: 11110709) Aguiar R.C.T. … Shipp M.A. (Blood 2000) 2 67
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 67

Products for PARP9 Gene

Sources for PARP9 Gene

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