Aliases for PARP9 Gene
External Ids for PARP9 Gene
Previous GeneCards Identifiers for PARP9 Gene
GeneCards Summary for PARP9 Gene
PARP9 (Poly (ADP-Ribose) Polymerase Family, Member 9) is a Protein Coding gene. Diseases associated with PARP9 include b-cell lymphomas and diffuse large b-cell lymphoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and all-trans-Retinoic Acid Mediated Apoptosis. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.
UniProtKB/Swiss-Prot for PARP9 Gene
In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.