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Aliases for PARP9 Gene

Aliases for PARP9 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 9 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 9 3 4
  • B Aggressive Lymphoma Protein 3 4
  • PARP-9 3 4
  • ARTD9 3 4
  • BAL1 3 4
  • BAL 3 4
  • Poly (ADP-Ribose) Polymerase 9 3
  • Poly [ADP-Ribose] Polymerase 9 3
  • EC 2.4.2.30 4
  • MGC:7868 3

External Ids for PARP9 Gene

Previous GeneCards Identifiers for PARP9 Gene

  • GC03M123729
  • GC03M122246
  • GC03M119620

Summaries for PARP9 Gene

GeneCards Summary for PARP9 Gene

PARP9 (Poly(ADP-Ribose) Polymerase Family Member 9) is a Protein Coding gene. Diseases associated with PARP9 include B-Cell Lymphomas and Lymphoma. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP9 Gene

  • In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.

Tocris Summary for PARP9 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Additional gene information for PARP9 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP9 Gene

Genomics for PARP9 Gene

Regulatory Elements for PARP9 Gene

Enhancers for PARP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H122678 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -116.6 -116622 5 HDGF SIN3A ZNF2 YY1 GLIS2 ZNF143 ZNF207 ATF7 RUNX3 YY2 PARP14 DTX3L PARP9 HSPBAP1 DIRC2 LINC02035 CSTA KPNA1
GH03H122073 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +487.2 487247 7 HDGF PKNOX1 FOXA2 TBL1XR1 SIN3A BMI1 BATF RFX5 ZNF143 ATF7 CD86 ENSG00000202388 DTX3L PARP9 CCDC58 FAM162A IQCB1 EAF2 CSTA HCLS1
GH03H122773 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -209.5 -209465 1 CTCF PKNOX1 FOSL1 EED ATF7 IKZF2 SMARCA5 ZNF687 HLF NR2F1 PARP14 HSPBAP1 DTX3L PARP9 DIRC2 CSTA KPNA1
GH03H122766 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -203.6 -203646 3 POLR2A DIRC2 HSPBAP1 PARP14 PARP9 DTX3L LINC02035 CSTA KPNA1
GH03H122099 1.3 FANTOM5 ENCODE dbSUPER 9.4 +464.4 464384 2 CTCF ZNF687 RFX1 CHD4 RFX5 EED CREB1 IKZF2 CREM PARP9 DTX3L CD86 HCLS1 CSTA EAF2 ILDR1 CASR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP9 on UCSC Golden Path with GeneCards custom track

Promoters for PARP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157339 376 1801 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ZNF143 KLF7 ATF7 SP3

Genomic Location for PARP9 Gene

Chromosome:
3
Start:
122,527,910 bp from pter
End:
122,564,676 bp from pter
Size:
36,767 bases
Orientation:
Minus strand

Genomic View for PARP9 Gene

Genes around PARP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP9 Gene

Proteins for PARP9 Gene

  • Protein details for PARP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXQ6-PARP9_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 9
    Protein Accession:
    Q8IXQ6
    Secondary Accessions:
    • A8KA94
    • B2R8S9
    • E9PFM7
    • Q8TCP3
    • Q9BZL8
    • Q9BZL9

    Protein attributes for PARP9 Gene

    Size:
    854 amino acids
    Molecular mass:
    96343 Da
    Quaternary structure:
    • Interacts with DTX3L. Interacts with PARP1 (when poly-ADP-ribosylated).

    Three dimensional structures from OCA and Proteopedia for PARP9 Gene

    Alternative splice isoforms for PARP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP9 Gene

Post-translational modifications for PARP9 Gene

  • Ubiquitination at Lys477, posLast=632632, and posLast=740740
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PARP9 Gene

Domains & Families for PARP9 Gene

Gene Families for PARP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PARP9 Gene

Suggested Antigen Peptide Sequences for PARP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXQ6

UniProtKB/Swiss-Prot:

PARP9_HUMAN :
  • The domain macro 2 is required for recruitment to DNA damage sites.
Domain:
  • The domain macro 2 is required for recruitment to DNA damage sites.
genes like me logo Genes that share domains with PARP9: view

Function for PARP9 Gene

Molecular function for PARP9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFN-gamma in B-cell lymphoma cell lines.

Enzyme Numbers (IUBMB) for PARP9 Gene

Phenotypes From GWAS Catalog for PARP9 Gene

Gene Ontology (GO) - Molecular Function for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IMP 16061477
GO:0003950 NAD+ ADP-ribosyltransferase activity TAS --
GO:0004857 enzyme inhibitor activity IDA 27796300
GO:0005515 protein binding IPI 16809771
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PARP9: view
genes like me logo Genes that share phenotypes with PARP9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PARP9

CRISPR Products

miRNA for PARP9 Gene

miRTarBase miRNAs that target PARP9

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP9 Gene

Localization for PARP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP9 Gene

Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP9 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 11110709
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 16809771
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PARP9: view

Pathways & Interactions for PARP9 Gene

genes like me logo Genes that share pathways with PARP9: view

Pathways by source for PARP9 Gene

Gene Ontology (GO) - Biological Process for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 16061477
GO:0002230 positive regulation of defense response to virus by host IGI 26479788
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IMP 23230272
GO:0006471 protein ADP-ribosylation IDA 28525742
genes like me logo Genes that share ontologies with PARP9: view

No data available for SIGNOR curated interactions for PARP9 Gene

Drugs & Compounds for PARP9 Gene

(6) Drugs for PARP9 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 937,941
NAD Pharma Full agonist, Agonist 0
BYK 204165 Pharma PARP-1 inhibitor,potent and selective, Selective PARP-1 inhibitor 0
EB 47 Pharma Potent PARP-1 inhibitor 0
JW 55 Pharma PARP domain inhibitor, Tankyrase inhibitor 0

(1) Additional Compounds for PARP9 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP9 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3
genes like me logo Genes that share compounds with PARP9: view

Transcripts for PARP9 Gene

Unigene Clusters for PARP9 Gene

Poly (ADP-ribose) polymerase family, member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for PARP9 Gene

GeneLoc Exon Structure for
PARP9
ECgene alternative splicing isoforms for
PARP9

Expression for PARP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP9 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for PARP9 Gene

This gene is overexpressed in Lymph node (20.6), Spleen (6.9), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP9 Gene



Protein tissue co-expression partners for PARP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP9 Gene:

PARP9

SOURCE GeneReport for Unigene cluster for PARP9 Gene:

Hs.518200

mRNA Expression by UniProt/SwissProt for PARP9 Gene:

Q8IXQ6-PARP9_HUMAN
Tissue specificity: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells.

Evidence on tissue expression from TISSUES for PARP9 Gene

  • Blood(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PARP9: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP9 Gene

Orthologs for PARP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP9 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia PARP9 33 34
  • 79.07 (n)
dog
(Canis familiaris)
Mammalia PARP9 33 34
  • 78.28 (n)
mouse
(Mus musculus)
Mammalia Parp9 33 16 34
  • 74.19 (n)
rat
(Rattus norvegicus)
Mammalia Parp9 33
  • 73.18 (n)
oppossum
(Monodelphis domestica)
Mammalia PARP9 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP9 33 34
  • 51.99 (n)
lizard
(Anolis carolinensis)
Reptilia PARP9 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp9 33
  • 47.11 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-219a4.6 33
  • 50.02 (n)
PARP9 34
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
Species where no ortholog for PARP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP9 Gene

ENSEMBL:
Gene Tree for PARP9 (if available)
TreeFam:
Gene Tree for PARP9 (if available)

Paralogs for PARP9 Gene

Paralogs for PARP9 Gene

(2) SIMAP similar genes for PARP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PARP9: view

Variants for PARP9 Gene

Sequence variations from dbSNP and Humsavar for PARP9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000243574 -- 122,553,978(+) TCACC(A/G)CTACC intron-variant
rs1000276319 -- 122,546,731(+) ACTGA(A/T)AGATG intron-variant
rs1000333995 -- 122,540,166(+) AATGT(A/G)TACTT intron-variant
rs1000449412 -- 122,547,203(+) GATTC(G/T)CCTGC intron-variant
rs1000565528 -- 122,542,157(+) CATTA(C/T)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP9 Gene

Variant ID Type Subtype PubMed ID
esv2763295 CNV loss 21179565

Variation tolerance for PARP9 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP9 Gene

Disorders for PARP9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PARP9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphomas
  • b-cell lymphoma
lymphoma
  • lymphoid cancer
diffuse large b-cell lymphoma
  • dlbcl
- elite association - COSMIC cancer census association via MalaCards
Search PARP9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PARP9_HUMAN
  • Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors (PubMed:11110709). {ECO:0000269 PubMed:11110709}.

Relevant External Links for PARP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP9
genes like me logo Genes that share disorders with PARP9: view

No data available for Genatlas for PARP9 Gene

Publications for PARP9 Gene

  1. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. (PMID: 16809771) Juszczynski P … Shipp MA (Molecular and cellular biology 2006) 3 4 22 60
  2. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. (PMID: 11110709) Aguiar RC … Shipp MA (Blood 2000) 2 3 4 60
  3. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. (PMID: 23230272) Yan Q … Shipp MA (Molecular and cellular biology 2013) 3 4 60
  4. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PMID: 16061477) Aguiar RC … Shipp MA (The Journal of biological chemistry 2005) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for PARP9 Gene

  • Addgene plasmids for PARP9

Sources for PARP9 Gene

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