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Aliases for PARP8 Gene

Aliases for PARP8 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 8 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 16 3 4
  • EC 4 58
  • ARTD16 3 4
  • Poly [ADP-Ribose] Polymerase 8 3
  • PART16 3
  • PARP-8 4

External Ids for PARP8 Gene

Previous GeneCards Identifiers for PARP8 Gene

  • GC05P049998
  • GC05P046926
  • GC05P049961

Summaries for PARP8 Gene

GeneCards Summary for PARP8 Gene

PARP8 (Poly(ADP-Ribose) Polymerase Family Member 8) is a Protein Coding gene. Among its related pathways are Metabolism and Mesodermal Commitment Pathway. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.

Tocris Summary for PARP8 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP8 Gene

Additional gene information for PARP8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP8 Gene

Genomics for PARP8 Gene

Regulatory Elements for PARP8 Gene

Enhancers for PARP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H050664 1 ENCODE 34.9 +1.5 1537 5.2 HDGF SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF416 ZNF207 ATF7 RUNX3 PARP8 ENSG00000249405
GH05H050653 0.9 Ensembl ENCODE 35 -11.6 -11638 0.7 ZNF687 TRIM22 MAX ELF1 POLR2A TARDBP IKZF2 MYC PARP8 ENSG00000271752 LOC202319
GH05H050742 0.9 Ensembl ENCODE 33.5 +79.0 79005 4.2 GFI1B ZNF10 FEZF1 ZSCAN21 ZNF121 PRDM6 IKZF1 BCL6B IKZF2 PRDM1 PARP8 ENSG00000249405
GH05H050594 0.7 Ensembl ENCODE 39.3 -70.5 -70511 1.1 JUND FOS PARP8 ENSG00000271455 GC05M050468
GH05H050710 1.1 Ensembl ENCODE 18.7 +46.0 45978 3.5 PKNOX1 TAF1 SIN3A MAX RAD21 RELA YY1 GATA3 POLR2A ZNF547 PARP8 ENSG00000249405
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP8 on UCSC Golden Path with GeneCards custom track

Promoters for PARP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180307 1601 3001 HDGF SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF416 ZNF207 ATF7 RUNX3

Genomic Locations for PARP8 Gene

Genomic Locations for PARP8 Gene
180,624 bases
Plus strand

Genomic View for PARP8 Gene

Genes around PARP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP8 Gene

Proteins for PARP8 Gene

  • Protein details for PARP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly [ADP-ribose] polymerase 8
    Protein Accession:
    Secondary Accessions:
    • Q3KRB7
    • Q6DHZ1
    • Q9H754

    Protein attributes for PARP8 Gene

    854 amino acids
    Molecular mass:
    95871 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI05790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP8 Gene


neXtProt entry for PARP8 Gene

Selected DME Specific Peptides for PARP8 Gene


Post-translational modifications for PARP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP8 Gene

Gene Families for PARP8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP8 Gene

Suggested Antigen Peptide Sequences for PARP8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP8: view

No data available for UniProtKB/Swiss-Prot for PARP8 Gene

Function for PARP8 Gene

Molecular function for PARP8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP8 Gene

Phenotypes From GWAS Catalog for PARP8 Gene

Gene Ontology (GO) - Molecular Function for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP8: view
genes like me logo Genes that share phenotypes with PARP8: view

Animal Models for PARP8 Gene

MGI Knock Outs for PARP8:

Animal Model Products

CRISPR Products

miRNA for PARP8 Gene

miRTarBase miRNAs that target PARP8

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP8 Gene

Localization for PARP8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP8 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with PARP8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PARP8 Gene

Pathways & Interactions for PARP8 Gene

genes like me logo Genes that share pathways with PARP8: view

Interacting Proteins for PARP8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8N3A8-PARP8_HUMAN ENSP00000281631 for PARP8 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PARP8 Gene


No data available for SIGNOR curated interactions for PARP8 Gene

Drugs & Compounds for PARP8 Gene

(6) Drugs for PARP8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 937,941
NAD Pharma Full agonist, Agonist 0

(1) Additional Compounds for PARP8 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for PARP8 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP8: view

Transcripts for PARP8 Gene

Unigene Clusters for PARP8 Gene

Poly (ADP-ribose) polymerase family, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - - -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP3: -

Relevant External Links for PARP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP8 Gene

This gene is overexpressed in Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for PARP8 Gene

This gene is overexpressed in Monocytes (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARP8 Gene

Protein tissue co-expression partners for PARP8 Gene

NURSA nuclear receptor signaling pathways regulating expression of PARP8 Gene:


SOURCE GeneReport for Unigene cluster for PARP8 Gene:


Evidence on tissue expression from TISSUES for PARP8 Gene

  • Intestine(4.3)
  • Muscle(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with PARP8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP8 Gene

Orthologs for PARP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PARP8 33 34
  • 99.68 (n)
(Bos Taurus)
Mammalia PARP8 33 34
  • 93.17 (n)
(Canis familiaris)
Mammalia PARP8 33 34
  • 92.78 (n)
(Monodelphis domestica)
Mammalia PARP8 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia PARP8 34
  • 91 (a)
(Mus musculus)
Mammalia Parp8 33 16 34
  • 89.24 (n)
(Rattus norvegicus)
Mammalia Parp8 33
  • 89.14 (n)
(Gallus gallus)
Aves PARP8 33 34
  • 85.19 (n)
(Anolis carolinensis)
Reptilia PARP8 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia parp8 33
  • 82.96 (n)
(Danio rerio)
Actinopterygii parp8 33 34
  • 74.37 (n)
Dr.25837 33
Species where no ortholog for PARP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP8 Gene

Gene Tree for PARP8 (if available)
Gene Tree for PARP8 (if available)

Paralogs for PARP8 Gene

Paralogs for PARP8 Gene Pseudogenes for PARP8 Gene

genes like me logo Genes that share paralogs with PARP8: view

Variants for PARP8 Gene

Sequence variations from dbSNP and Humsavar for PARP8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_035853 A colorectal cancer sample
rs1000052886 -- 50,688,972(+) TTTGT(A/G)CCAGA intron-variant
rs1000083098 -- 50,743,579(+) AGTGT(A/G)TCTGG intron-variant
rs1000083524 -- 50,688,675(+) AAGTA(A/T)TTATG intron-variant
rs1000094818 -- 50,784,044(+) TAAAA(A/C)ATCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP8 Gene

Variant ID Type Subtype PubMed ID
nsv980791 CNV duplication 23825009
nsv968910 CNV duplication 23825009
nsv968172 CNV duplication 23825009
nsv965013 CNV duplication 23825009
nsv950692 CNV duplication 24416366
nsv819124 CNV loss 19587683
nsv818352 CNV loss 17921354
nsv598116 CNV gain 21841781
nsv598115 CNV loss 21841781
nsv598108 CNV gain 21841781
nsv523212 CNV gain 19592680
nsv521214 CNV loss 19592680
nsv507252 OTHER sequence alteration 20534489
nsv471838 CNV novel sequence insertion 20440878
nsv462164 CNV loss 19166990
nsv462163 CNV loss 19166990
nsv1133599 CNV deletion 24896259
nsv1114682 CNV deletion 24896259
esv3894187 CNV loss 25118596
esv3605029 CNV gain 21293372
esv2759342 CNV gain 17122850
esv21955 CNV gain 19812545
dgv9774n54 CNV loss 21841781
dgv9773n54 CNV loss 21841781
dgv702n27 CNV loss 19166990
dgv5665n100 CNV gain 25217958

Variation tolerance for PARP8 Gene

Residual Variation Intolerance Score: 6.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP8 Gene

Disorders for PARP8 Gene

Relevant External Links for PARP8

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PARP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP8 Gene

Publications for PARP8 Gene

  1. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens AL … Gingras AC (Science signaling 2013) 3 60
  5. Genetics of callous-unemotional behavior in children. (PMID: 23874384) Viding E … Plomin R (PloS one 2013) 3 60

Products for PARP8 Gene

Sources for PARP8 Gene

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