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Aliases for PARP8 Gene

Aliases for PARP8 Gene

  • Poly (ADP-Ribose) Polymerase Family, Member 8 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 16 3 4
  • EC 2.4.2.30 4 64
  • ARTD16 3 4
  • Poly [ADP-Ribose] Polymerase 8 3
  • PART16 3
  • PARP-8 4

External Ids for PARP8 Gene

Summaries for PARP8 Gene

GeneCards Summary for PARP8 Gene

PARP8 (Poly (ADP-Ribose) Polymerase Family, Member 8) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.

Tocris Summary for PARP8 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes, stroke and cardiovascular disease.

Gene Wiki entry for PARP8 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP8 Gene

Genomics for PARP8 Gene

Genomic Location for PARP8 Gene

Start:
50,665,899 bp from pter
End:
50,846,522 bp from pter
Size:
180,624 bases
Orientation:
Plus strand

Genomic View for PARP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP8 Gene

Regulatory Elements for PARP8 Gene

Proteins for PARP8 Gene

  • Protein details for PARP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3A8-PARP8_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 8
    Protein Accession:
    Q8N3A8
    Secondary Accessions:
    • Q3KRB7
    • Q6DHZ1
    • Q9H754

    Protein attributes for PARP8 Gene

    Size:
    854 amino acids
    Molecular mass:
    95871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI05790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP8 Gene

Proteomics data for PARP8 Gene at MOPED

Post-translational modifications for PARP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PARP8 Gene

Gene Families for PARP8 Gene

HGNC:
  • PARP :Poly (ADP-ribose) polymerases

Protein Domains for PARP8 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PARP8_HUMAN
Domain:
  • Contains 1 PARP catalytic domain.:
    • Q8N3A8
genes like me logo Genes that share domains with PARP8: view

Function for PARP8 Gene

Molecular function for PARP8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP8 Gene

Gene Ontology (GO) - Molecular Function for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
genes like me logo Genes that share ontologies with PARP8: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PARP8 Gene

Localization for PARP8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP8 Gene COMPARTMENTS Subcellular localization image for PARP8 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with PARP8: view

Pathways for PARP8 Gene

SuperPathways for PARP8 Gene

No Data Available

Interacting Proteins for PARP8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281631%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000300161%0d%0a
Selected Interacting proteins: ENSP00000281631 for PARP8 Gene via STRING

Gene Ontology (GO) - Biological Process for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PARP8: view

No data available for Pathways by source for PARP8 Gene

Compounds for PARP8 Gene

(19) ApexBio Compounds for PARP8 Gene

Compound Action Cas Number
4-HQN Inhibitor of PARP [491-36-1]
A-966492 novel and potent inhibitor of PARP1 and PARP2 [934162-61-5]
ABT-888 (Veliparib) potent inhibitor of PARP1 and PARP2 [912444-00-9]
AG-14361 potent inhibitor of PARP1 [328543-09-5]
AZD2461 novel PARP inhibitor [1174043-16-3]
BMN 673 potent and selective inhibitor of PARP1,PARP2 [1207456-01-6]
BYK 204165 Potent and selective PARP1 inhibitor [1104546-89-5]
BYK 49187 PARP-1 and PARP-2 inhibitor [163120-31-8]
DR 2313 competitive inhibitor of PARP1 and PARP2 [284028-90-6]
EB 47 potent inhibitor of PARP-1 [1190332-25-2]
Iniparib (BSI-201) inhibitor of PARP1 [160003-66-7]
INO-1001 potent inhibitor of PARP [3544-24-9]
ME0328 potent and selective PARP inhibitor [1445251-22-8]
MK-4827 potent, selective inhibitor of PARP 1 and PARP 2 [1038915-60-4]
NU 1025 Novel, potent inhibitor of PARPK [90417-38-2]
Olaparib (AZD2281, Ku-0059436) potent inhibitor of PARP1and PARP2 [763113-22-0]
PJ34 novel potent specific inhibitor of PARP-l/2. [344458-19-1]
Rucaparib (AG-014699,PF-01367338) inhibitor of PARP1 [459868-92-9]
UPF 1069 selective inhibitor of PARP2 [1048371-03-4]

(5) Tocris Compounds for PARP8 Gene

Compound Action Cas Number
JW 55 Tankyrase inhibitor; inhibits canonical Wnt signaling [664993-53-7]
NU 1025 Potent PARP inhibitor [90417-38-2]
PJ 34 hydrochloride Potent PARP inhibitor [344458-15-7]
WIKI4 Tankyrase inhibitor; inhibits Wnt signaling [838818-26-1]
XAV 939 Tankyrase inhibitor; inhibits Wnt signaling [284028-89-3]

(1) HMDB Compounds for PARP8 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with PARP8: view

Transcripts for PARP8 Gene

Unigene Clusters for PARP8 Gene

Poly (ADP-ribose) polymerase family, member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for PARP8 Gene

GeneLoc Exon Structure for
PARP8
ECgene alternative splicing isoforms for
PARP8

Expression for PARP8 Gene

mRNA expression in normal human tissues for PARP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP8 Gene

This gene is overexpressed in Whole Blood (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PARP8 Gene

SOURCE GeneReport for Unigene cluster for PARP8 Gene Hs.369581

genes like me logo Genes that share expressions with PARP8: view

Orthologs for PARP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP8 36
  • 99.68 (n)
  • 99.64 (a)
PARP8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARP8 36
  • 93.17 (n)
  • 97.42 (a)
PARP8 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP8 36
  • 92.78 (n)
  • 97.54 (a)
PARP8 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp8 36
  • 89.24 (n)
  • 96.36 (a)
Parp8 16
Parp8 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARP8 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP8 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp8 36
  • 89.14 (n)
  • 96.77 (a)
chicken
(Gallus gallus)
Aves PARP8 36
  • 85.19 (n)
  • 93.2 (a)
PARP8 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP8 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp8 36
  • 82.96 (n)
  • 91.05 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.25837 36
parp8 36
  • 74.37 (n)
  • 81.6 (a)
parp8 37
  • 72 (a)
OneToOne
Species with no ortholog for PARP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP8 Gene

ENSEMBL:
Gene Tree for PARP8 (if available)
TreeFam:
Gene Tree for PARP8 (if available)

Paralogs for PARP8 Gene

Paralogs for PARP8 Gene

Pseudogenes.org Pseudogenes for PARP8 Gene

genes like me logo Genes that share paralogs with PARP8: view

Variants for PARP8 Gene

Sequence variations from dbSNP and Humsavar for PARP8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26062 -- 50,824,637(+) CTTTA(C/G)GGACA intron-variant
rs26065 -- 50,791,382(+) TTCAC(A/G)GTCAC intron-variant
rs26066 -- 50,800,128(+) ttgta(A/G)ttttc intron-variant
rs26067 -- 50,793,817(+) TAAAA(A/G)TTGAT intron-variant
rs26068 -- 50,782,165(+) CTATC(C/T)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP8 Gene

Variant ID Type Subtype PubMed ID
nsv523212 CNV Gain 19592680
dgv1798e1 CNV Complex 17122850
esv21955 CNV Gain 19812545
nsv818352 CNV Loss 17921354
nsv521214 CNV Loss 19592680
dgv702n27 CNV Loss 19166990
nsv819124 CNV Loss 19587683
nsv462163 CNV Loss 19166990
nsv462164 CNV Loss 19166990
nsv507252 CNV Insertion 20534489

Relevant External Links for PARP8 Gene

HapMap Linkage Disequilibrium report
PARP8
Human Gene Mutation Database (HGMD)
PARP8

Disorders for PARP8 Gene

(1) University of Copenhagen DISEASES for PARP8 Gene

Relevant External Links for PARP8

Genetic Association Database (GAD)
PARP8
genes like me logo Genes that share disorders with PARP8: view

No data available for UniProtKB/Swiss-Prot for PARP8 Gene

Publications for PARP8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for PARP8 Gene

Sources for PARP8 Gene

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