Aliases for PARP8 Gene
External Ids for PARP8 Gene
Previous GeneCards Identifiers for PARP8 Gene
GeneCards Summary for PARP8 Gene
PARP8 (Poly (ADP-Ribose) Polymerase Family, Member 8) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes, stroke and cardiovascular disease.