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Aliases for PARP8 Gene

Aliases for PARP8 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 8 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 16 3 4
  • EC 2.4.2.30 4 61
  • ARTD16 3 4
  • Poly [ADP-Ribose] Polymerase 8 3
  • PART16 3
  • PARP-8 4

External Ids for PARP8 Gene

Previous GeneCards Identifiers for PARP8 Gene

  • GC05P049998
  • GC05P046926
  • GC05P049961

Summaries for PARP8 Gene

GeneCards Summary for PARP8 Gene

PARP8 (Poly(ADP-Ribose) Polymerase Family Member 8) is a Protein Coding gene. Among its related pathways are NAD metabolism and Mesodermal Commitment Pathway. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.

Tocris Summary for PARP8 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP8 Gene

Genomics for PARP8 Gene

Regulatory Elements for PARP8 Gene

Enhancers for PARP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G050664 1 ENCODE 34.9 +1.5 1537 5.2 HDGF SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF416 ZNF207 ZNF263 YY2 PARP8 ENSG00000249405
GH05G050742 0.9 Ensembl ENCODE 33.5 +79.0 79005 4.2 GFI1B ZNF10 FEZF1 ZNF121 ZSCAN21 PRDM6 IKZF1 BCL6B RELB IKZF2 PARP8 ENSG00000249405
GH05G050653 0.8 Ensembl ENCODE 35 -11.6 -11638 0.7 RAD51 USF1 BHLHE40 TARDBP TRIM22 MAX MYC PARP8 ENSG00000271752 LOC202319
GH05G050594 0.7 Ensembl ENCODE 39.3 -70.5 -70511 1.1 JUND FOS PARP8 ENSG00000271455 GC05M050468
GH05G050589 0.6 ENCODE 36.8 -73.5 -73527 4.9 PKNOX1 GATA3 MTA2 SCRT2 MLLT1 TBX21 TCF7L2 PARP8 EMB ENSG00000271455 GC05M050468
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP8 on UCSC Golden Path with GeneCards custom track

Promoters for PARP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180307 1601 3001 HDGF SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF416 ZNF207 ZNF263 YY2

Genomic Location for PARP8 Gene

Chromosome:
5
Start:
50,665,899 bp from pter
End:
50,846,522 bp from pter
Size:
180,624 bases
Orientation:
Plus strand

Genomic View for PARP8 Gene

Genes around PARP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP8 Gene

Proteins for PARP8 Gene

  • Protein details for PARP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3A8-PARP8_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 8
    Protein Accession:
    Q8N3A8
    Secondary Accessions:
    • Q3KRB7
    • Q6DHZ1
    • Q9H754

    Protein attributes for PARP8 Gene

    Size:
    854 amino acids
    Molecular mass:
    95871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI05790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP8 Gene

Selected DME Specific Peptides for PARP8 Gene

Q8N3A8:
  • DHVCTRFFFVYEDGQVGDANINTQ
  • GSTFAFHGSHIENWHSILRNGLV
  • IFEPYPSVVDP
  • SIREMTQ
  • HQFLLLSSPPAKE
  • SSISFGYSGM
  • LNEYCVVCDE
  • DPLAHPLLQW
  • CIALCEVITS
  • YLEIKKQMDK
  • ISSNRSHIVKLP

Post-translational modifications for PARP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP8 Gene

Gene Families for PARP8 Gene

Protein Domains for PARP8 Gene

Suggested Antigen Peptide Sequences for PARP8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP8: view

No data available for UniProtKB/Swiss-Prot for PARP8 Gene

Function for PARP8 Gene

Molecular function for PARP8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP8 Gene

Gene Ontology (GO) - Molecular Function for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP8: view
genes like me logo Genes that share phenotypes with PARP8: view

Animal Models for PARP8 Gene

MGI Knock Outs for PARP8:

Animal Model Products

CRISPR Products

miRNA for PARP8 Gene

miRTarBase miRNAs that target PARP8

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP8 Gene

Localization for PARP8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP8 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with PARP8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PARP8 Gene

Pathways & Interactions for PARP8 Gene

genes like me logo Genes that share pathways with PARP8: view

Interacting Proteins for PARP8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281631%0d%0a9606.ENSP00000320176%0d%0a
Selected Interacting proteins: Q8N3A8-PARP8_HUMAN ENSP00000281631 for PARP8 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PARP8 Gene

None

No data available for SIGNOR curated interactions for PARP8 Gene

Drugs & Compounds for PARP8 Gene

(6) Drugs for PARP8 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 919,923
NAD Pharma Full agonist, Agonist 0
BYK 204165 Pharma PARP-1 inhibitor,potent and selective, Selective PARP-1 inhibitor 0
EB 47 Pharma Potent PARP-1 inhibitor 0
JW 55 Pharma PARP domain inhibitor, Tankyrase inhibitor 0

(1) Additional Compounds for PARP8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP8 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3
genes like me logo Genes that share compounds with PARP8: view

Transcripts for PARP8 Gene

Unigene Clusters for PARP8 Gene

Poly (ADP-ribose) polymerase family, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for PARP8 Gene

GeneLoc Exon Structure for
PARP8
ECgene alternative splicing isoforms for
PARP8

Expression for PARP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP8 Gene

This gene is overexpressed in Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for PARP8 Gene

This gene is overexpressed in Monocytes (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARP8 Gene



Protein tissue co-expression partners for PARP8 Gene

NURSA nuclear receptor signaling pathways regulating expression of PARP8 Gene:

PARP8

SOURCE GeneReport for Unigene cluster for PARP8 Gene:

Hs.369581

Evidence on tissue expression from TISSUES for PARP8 Gene

  • Intestine(4.3)
  • Muscle(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with PARP8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP8 Gene

Orthologs for PARP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP8 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia PARP8 34 35
  • 93.17 (n)
dog
(Canis familiaris)
Mammalia PARP8 35 34
  • 92.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARP8 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP8 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp8 34 16 35
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Parp8 34
  • 89.14 (n)
chicken
(Gallus gallus)
Aves PARP8 34 35
  • 85.19 (n)
lizard
(Anolis carolinensis)
Reptilia PARP8 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp8 34
  • 82.96 (n)
zebrafish
(Danio rerio)
Actinopterygii parp8 34 35
  • 74.37 (n)
Dr.25837 34
Species where no ortholog for PARP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP8 Gene

ENSEMBL:
Gene Tree for PARP8 (if available)
TreeFam:
Gene Tree for PARP8 (if available)

Paralogs for PARP8 Gene

Paralogs for PARP8 Gene

Pseudogenes.org Pseudogenes for PARP8 Gene

genes like me logo Genes that share paralogs with PARP8: view

Variants for PARP8 Gene

Sequence variations from dbSNP and Humsavar for PARP8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_035853 A colorectal cancer sample
rs1000052886 -- 50,688,972(+) TTTGT(A/G)CCAGA intron-variant
rs1000083098 -- 50,743,579(+) AGTGT(A/G)TCTGG intron-variant
rs1000083524 -- 50,688,675(+) AAGTA(A/T)TTATG intron-variant
rs1000094818 -- 50,784,044(+) TAAAA(A/C)ATCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP8 Gene

Variant ID Type Subtype PubMed ID
dgv5665n100 CNV gain 25217958
dgv702n27 CNV loss 19166990
dgv9773n54 CNV loss 21841781
dgv9774n54 CNV loss 21841781
esv21955 CNV gain 19812545
esv2759342 CNV gain 17122850
esv3605029 CNV gain 21293372
esv3894187 CNV loss 25118596
nsv1114682 CNV deletion 24896259
nsv1133599 CNV deletion 24896259
nsv462163 CNV loss 19166990
nsv462164 CNV loss 19166990
nsv471838 CNV novel sequence insertion 20440878
nsv507252 OTHER sequence alteration 20534489
nsv521214 CNV loss 19592680
nsv523212 CNV gain 19592680
nsv598108 CNV gain 21841781
nsv598115 CNV loss 21841781
nsv598116 CNV gain 21841781
nsv818352 CNV loss 17921354
nsv819124 CNV loss 19587683
nsv950692 CNV duplication 24416366
nsv965013 CNV duplication 23825009
nsv968172 CNV duplication 23825009
nsv968910 CNV duplication 23825009
nsv980791 CNV duplication 23825009

Variation tolerance for PARP8 Gene

Residual Variation Intolerance Score: 6.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP8 Gene

Human Gene Mutation Database (HGMD)
PARP8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP8 Gene

Disorders for PARP8 Gene

Relevant External Links for PARP8

Genetic Association Database (GAD)
PARP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP8

No disorders were found for PARP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP8 Gene

Publications for PARP8 Gene

  1. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genetics of callous-unemotional behavior in children. (PMID: 23874384) Viding E. … Plomin R. (PLoS ONE 2013) 3 64
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3 64

Products for PARP8 Gene

Sources for PARP8 Gene

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