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Aliases for PARP8 Gene

Aliases for PARP8 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 8 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 16 3 4
  • EC 2.4.2.30 4 63
  • ARTD16 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 8 3
  • PART16 3
  • PARP-8 4

External Ids for PARP8 Gene

Previous GeneCards Identifiers for PARP8 Gene

  • GC05P049998
  • GC05P046926
  • GC05P049961

Summaries for PARP8 Gene

GeneCards Summary for PARP8 Gene

PARP8 (Poly(ADP-Ribose) Polymerase Family Member 8) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.

Tocris Summary for PARP8 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP8 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP8 Gene

Genomics for PARP8 Gene

Regulatory Elements for PARP8 Gene

Enhancers for PARP8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PARP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for PARP8 Gene

Chromosome:
5
Start:
50,665,899 bp from pter
End:
50,846,522 bp from pter
Size:
180,624 bases
Orientation:
Plus strand

Genomic View for PARP8 Gene

Genes around PARP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP8 Gene

Proteins for PARP8 Gene

  • Protein details for PARP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3A8-PARP8_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 8
    Protein Accession:
    Q8N3A8
    Secondary Accessions:
    • Q3KRB7
    • Q6DHZ1
    • Q9H754

    Protein attributes for PARP8 Gene

    Size:
    854 amino acids
    Molecular mass:
    95871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI05790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP8 Gene

Proteomics data for PARP8 Gene at MOPED

Post-translational modifications for PARP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP8 Gene

Gene Families for PARP8 Gene

Protein Domains for PARP8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARP8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3A8

UniProtKB/Swiss-Prot:

PARP8_HUMAN :
  • Contains 1 PARP catalytic domain.
Domain:
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP8: view

Function for PARP8 Gene

Molecular function for PARP8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP8 Gene

genes like me logo Genes that share phenotypes with PARP8: view

Animal Models for PARP8 Gene

MGI Knock Outs for PARP8:

Animal Model Products

miRNA for PARP8 Gene

miRTarBase miRNAs that target PARP8

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP8 Gene

Localization for PARP8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP8 Gene COMPARTMENTS Subcellular localization image for PARP8 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PARP8 Gene

Pathways & Interactions for PARP8 Gene

SuperPathways for PARP8 Gene

No Data Available

Interacting Proteins for PARP8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281631%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000300161%0d%0a
Selected Interacting proteins: ENSP00000281631 for PARP8 Gene via STRING

Gene Ontology (GO) - Biological Process for PARP8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PARP8 Gene

Drugs & Compounds for PARP8 Gene

(3) Drugs for PARP8 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 850,854
NU1025 Experimental Pharma Potent PARP inhibitor 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for PARP8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP8 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
DR 2313 PARP-1 and PARP-2 inhibitor 284028-90-6
NU 1025 Potent PARP inhibitor 90417-38-2
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
genes like me logo Genes that share compounds with PARP8: view

Transcripts for PARP8 Gene

Unigene Clusters for PARP8 Gene

Poly (ADP-ribose) polymerase family, member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for PARP8 Gene

GeneLoc Exon Structure for
PARP8
ECgene alternative splicing isoforms for
PARP8

Expression for PARP8 Gene

mRNA expression in normal human tissues for PARP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP8 Gene

This gene is overexpressed in Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for PARP8 Gene

This gene is overexpressed in Monocytes (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARP8 Gene



SOURCE GeneReport for Unigene cluster for PARP8 Gene Hs.369581

genes like me logo Genes that share expression patterns with PARP8: view

Protein tissue co-expression partners for PARP8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PARP8 Gene

Orthologs for PARP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARP8 35
  • 93.17 (n)
  • 97.42 (a)
PARP8 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP8 35
  • 92.78 (n)
  • 97.54 (a)
PARP8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp8 35
  • 89.24 (n)
  • 96.36 (a)
Parp8 16
Parp8 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARP8 35
  • 99.68 (n)
  • 99.64 (a)
PARP8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp8 35
  • 89.14 (n)
  • 96.77 (a)
oppossum
(Monodelphis domestica)
Mammalia PARP8 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP8 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP8 35
  • 85.19 (n)
  • 93.2 (a)
PARP8 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP8 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp8 35
  • 82.96 (n)
  • 91.05 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.25837 35
parp8 35
  • 74.37 (n)
  • 81.6 (a)
parp8 36
  • 72 (a)
OneToOne
Species with no ortholog for PARP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP8 Gene

ENSEMBL:
Gene Tree for PARP8 (if available)
TreeFam:
Gene Tree for PARP8 (if available)

Paralogs for PARP8 Gene

Paralogs for PARP8 Gene

Pseudogenes.org Pseudogenes for PARP8 Gene

genes like me logo Genes that share paralogs with PARP8: view

Variants for PARP8 Gene

Sequence variations from dbSNP and Humsavar for PARP8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_035853 A colorectal cancer sample
rs26062 -- 50,824,637(+) CTTTA(C/G)GGACA intron-variant
rs26065 -- 50,791,382(+) TTCAC(A/G)GTCAC intron-variant
rs26066 -- 50,800,128(+) ttgta(A/G)ttttc intron-variant
rs26067 -- 50,793,817(+) TAAAA(A/G)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP8 Gene

Variant ID Type Subtype PubMed ID
nsv523212 CNV Gain 19592680
dgv1798e1 CNV Complex 17122850
esv21955 CNV Gain 19812545
nsv818352 CNV Loss 17921354
nsv521214 CNV Loss 19592680
dgv702n27 CNV Loss 19166990
nsv819124 CNV Loss 19587683
nsv462163 CNV Loss 19166990
nsv462164 CNV Loss 19166990
nsv507252 CNV Insertion 20534489

Variation tolerance for PARP8 Gene

Residual Variation Intolerance Score: 6.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP8 Gene

HapMap Linkage Disequilibrium report
PARP8
Human Gene Mutation Database (HGMD)
PARP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP8 Gene

Disorders for PARP8 Gene

Relevant External Links for PARP8

Genetic Association Database (GAD)
PARP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP8

No disorders were found for PARP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP8 Gene

Publications for PARP8 Gene

  1. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3 67
  2. Genetics of callous-unemotional behavior in children. (PMID: 23874384) Viding E. … Plomin R. (PLoS ONE 2013) 3
  3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  4. Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. (PMID: 22685421) Fan Q. … Saw S.M. (PLoS Genet. 2012) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for PARP8 Gene

Sources for PARP8 Gene

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