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PARP8 Gene

protein-coding   GIFtS: 50
GCID: GC05P049961

Poly (ADP-Ribose) Polymerase Family, Member 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly (ADP-Ribose) Polymerase Family, Member 81 2     pART162
ARTD162 3     Poly [ADP-Ribose] Polymerase 82
ADP-Ribosyltransferase Diphtheria Toxin-Like 162 3     PARP-83
EC 2.4.2.303 8     

External Ids:    HGNC: 261241   Entrez Gene: 796682   Ensembl: ENSG000001518837   UniProtKB: Q8N3A83   

Export aliases for PARP8 gene to outside databases

Previous GC identifers: GC05P049998 GC05P046926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PARP8 Gene:
PARP8 (poly (ADP-ribose) polymerase family, member 8) is a protein-coding gene. Diseases associated with PARP8 include diphtheria, and root resorption. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.

summary for PARP8 Gene:
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the
addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to
glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain
polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,
stroke and cardiovascular disease.

Gene Wiki entry for PARP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARP8 gene promoter:
         HEN1   AREB6   FOXJ2 (long isoform)   Zic1   FOXO1a   FOXJ2   Evi-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARP8 promoter sequence
   Search Chromatin IP Primers for PARP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.1   Ensembl cytogenetic band:  5q11.1   HGNC cytogenetic band: 5q11.2

PARP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARP8 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P049961:  view genomic region     (about GC identifiers)

Start:
49,961,733 bp from pter      End:
50,142,356 bp from pter
Size:
180,624 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PARP8_HUMAN, Q8N3A8 (See protein sequence)
Recommended Name: Poly [ADP-ribose] polymerase 8  
Size: 854 amino acids; 95871 Da
Sequence caution: Sequence=AAI05790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q3KRB7 Q6DHZ1 Q9H754
Alternative splicing: 2 isoforms:  Q8N3A8-1   Q8N3A8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PARP8: NX_Q8N3A8

Explore proteomics data for PARP8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PARP8 (Q8N3A8) (see all 11)
     SIREMTQ  SSISFGYSGM  LNEYCVVCDE  DPLAHPLLQW 


    See PARP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171526.1  NP_001171527.1  NP_078891.2  

    ENSEMBL proteins: 
     ENSP00000422217   ENSP00000422183   ENSP00000421503   ENSP00000422288   ENSP00000426243  
     ENSP00000423133   ENSP00000281631   ENSP00000422355   ENSP00000427138   ENSP00000426679  
     ENSP00000424814   ENSP00000421708   ENSP00000424916   ENSP00000424485   ENSP00000423946  
     ENSP00000440851   ENSP00000439022  

    PARP8 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for PARP8
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PARP8
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    Novus Biologicals PARP8 Protein
    Novus Biologicals PARP8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PARP8

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    LSBio Antibodies in human, mouse, rat for PARP8

    PARP8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PARP8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PARP8
    Cloud-Clone Corp. CLIAs for PARP8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARP: Poly (ADP-ribose) polymerases

    1 InterPro protein domain:
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8N3A8

    ProtoNet protein and cluster: Q8N3A8

    UniProtKB/Swiss-Prot: PARP8_HUMAN, Q8N3A8
    Similarity: Contains 1 PARP catalytic domain


    PARP8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARP8_HUMAN, Q8N3A8
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

         Enzyme Number (IUBMB): EC 2.4.2.301 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
         
    PARP8 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Parp8 (no phenotypes)

    PARP8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Parp8tm1(KOMP)Wtsi for PARP8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARP8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARP8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARP8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARP8

    miRNA
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    Block miRNA regulation of human, mouse, rat PARP8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARP8 (see all 143):
    hsa-miR-26a-2* hsa-miR-3074-3p hsa-miR-519a hsa-miR-376a* hsa-miR-92b hsa-miR-490-5p hsa-miR-520b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidPARP8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PARP8
    Predesigned siRNA for gene silencing in human, mouse, rat PARP8

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PARP8

    Clone
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    OriGene clones in human, mouse for PARP8 (see all 17)
    OriGene ORF clones in mouse, rat for PARP8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PARP8 (NM_024615)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP8

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PARP8
    Browse ESI BIO Cell Lines and PureStem Progenitors for PARP8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    PARP8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PARP8
    Interactions:

        Search GeneGlobe Interaction Network for PARP8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for PARP8 (see all 19)     About this table
    CompoundAction CAS #
    4-HQNInhibitor of PARP[491-36-1]
    A-966492novel and potent inhibitor of PARP1 and PARP2[934162-61-5]
    ABT-888 (Veliparib)potent inhibitor of PARP1 and PARP2[912444-00-9]
    AG-14361potent inhibitor of PARP1[328543-09-5]
    AZD2461novel PARP inhibitor[1174043-16-3]
    BMN 673potent and selective inhibitor of PARP1,PARP2[1207456-01-6]
    BYK 204165Potent and selective PARP1 inhibitor[1104546-89-5]
    BYK 49187PARP-1 and PARP-2 inhibitor[163120-31-8]
    DR 2313competitive inhibitor of PARP1 and PARP2[284028-90-6]
    EB 47potent inhibitor of PARP-1[1190332-25-2]

    Compounds for PARP8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    1 HMDB Compound for PARP8    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PARP8 gene (3 alternative transcripts): 
    NM_001178055.1  NM_001178056.1  NM_024615.3  

    Unigene Cluster for PARP8:

    Poly (ADP-ribose) polymerase family, member 8
    Hs.369581  [show with all ESTs]
    Unigene Representative Sequence: NM_001178055
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000503790 ENST00000505697 ENST00000511363 ENST00000507812 ENST00000503888
    ENST00000510303 ENST00000502524 ENST00000515175 ENST00000513414 ENST00000510040
    ENST00000281631(uc003joo.3 uc003jop.3) ENST00000513738 ENST00000503665
    ENST00000503707 ENST00000514067 ENST00000503046 ENST00000503193 ENST00000515166

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PARP8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARP8 (see all 143):
    hsa-miR-26a-2* hsa-miR-3074-3p hsa-miR-519a hsa-miR-376a* hsa-miR-92b hsa-miR-490-5p hsa-miR-520b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidPARP8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PARP8
    Predesigned siRNA for gene silencing in human, mouse, rat PARP8
    Clone
    Products:
         
    OriGene clones in human, mouse for PARP8 (see all 17)
    OriGene ORF clones in mouse, rat for PARP8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PARP8 (NM_024615)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP8
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PARP8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARP8
      QuantiTect SYBR Green Assays in human, mouse, rat PARP8
      QuantiFast Probe-based Assays in human, mouse, rat PARP8

    Additional mRNA sequence: 

    AK024961.1 AK225188.1 AK289369.1 AK298680.1 AK314466.1 AL834477.1 BC037386.1 BC058033.1 
    BC075801.1 BC105789.1 

    13 DOTS entries:

    DT.112097  DT.40117588  DT.120877005  DT.306470  DT.95336399  DT.304722  DT.100826921  DT.40210965 
    DT.306469  DT.120877033  DT.40196229  DT.95106701  DT.95191873 

    Selected AceView cDNA sequences (see all 91):

    AI201016 AA977676 AA039596 AK024961 NM_024615 AA039597 AI016244 BQ421166 
    AI168822 AA826433 AA910504 AV713749 AA743485 AW131872 R81034 C01605 
    BC075801 CB070410 BP871383 AL834477 BU785518 AA367044 R80933 AA039956 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PARP8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:              -                                         -                                                           -                                       
    SP2:                                -     -                 -                                                           -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
    SP1:              -               
    SP2:                              
    SP3:              -               
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PARP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCGAAAGC
    PARP8 Expression
    About this image


    PARP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Thyroid (Endocrine System)
    PARP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARP8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369581
        Custom PCR Arrays for PARP8
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PARP8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARP8
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    QuantiFast Probe-based Assays in human, mouse, rat PARP8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PARP8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Parp81 , 5 poly (ADP-ribose) polymerase family, member 81, 5 89.24(n)1
    96.36(a)1
      13 (65.32 cM)5
    525521  NM_001081009.11  NP_001074478.11 
     1168548245 
    chicken
    (Gallus gallus)
    Aves PARP81 poly (ADP-ribose) polymerase family, member 8 85.19(n)
    93.2(a)
      427198  XM_424786.4  XP_424786.3 
    lizard
    (Anolis carolinensis)
    Reptilia PARP86
    poly (ADP-ribose) polymerase family, member 8
    91(a)
    1 ↔ 1
    2(4704871-4902456)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia parp81 poly (ADP-ribose) polymerase family, member 8 82.96(n)
    91.05(a)
      100490473  XM_002933029.2  XP_002933075.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.258372 Transcribed sequence with weak similarity to protein more 78.03(n)    CD604769.1 


    ENSEMBL Gene Tree for PARP8 (if available)
    TreeFam Gene Tree for PARP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARP8 gene
    PARP62  
    3 SIMAP similar genes for PARP8 using alignment to 15 protein entries:     PARP8_HUMAN (see all proteins):
    PARP6    PARP-6    CNOT2

    PARP8 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for PARP8
    PGOHUM00000251074 PGOHUM00000251078 PGOHUM00000251083 PGOHUM00000251133


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARP8 (see all 3546)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358534
    A colorectal cancer sample4--see VAR_0358532 S A mis40--------
    rs1473441971,2
    Cuntested150091131(+) AGTGCC/TCCCAA 6 A syn11Minor allele frequency- T:0.00NA 4550
    rs1118718651,2
    C,F--49959733(+) TTGGCG/AGGGCG 1 -- us2k12Minor allele frequency- A:0.09CSA WA 120
    rs1421804541,2
    --49959735(+) GGCGGC/GGCGGT 1 -- us2k10--------
    rs1839578361,2
    --49959766(+) TGTACA/GTATTT 1 -- us2k10--------
    rs1883583221,2
    --49959829(+) TCTTGC/TAGTCC 1 -- us2k10--------
    rs1917170891,2
    --49959962(+) TTAGAA/TCAGTT 1 -- us2k10--------
    rs1843062301,2
    --49960127(+) ACAGGC/TAAAAA 1 -- us2k10--------
    rs1892461351,2
    C--49960211(+) TAGAGA/TCTATC 1 -- us2k10--------
    rs1421880301,2
    --49960325(+) CTCTTA/GTGTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARP8 (49961733 - 50142356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for PARP8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507252CNV Insertion20534489
    nsv818352CNV Loss17921354
    nsv462164CNV Loss19166990
    dgv702n27CNV Loss19166990
    nsv521214CNV Loss19592680
    nsv462163CNV Loss19166990
    nsv819124CNV Loss19587683
    nsv523212CNV Gain19592680
    esv21955CNV Gain19812545
    dgv1798e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    5 diseases for PARP8:    
    About MalaCards
    diphtheria    root resorption    myopia    breast and colorectal cancer
    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for PARP8:
    Root resorption

    PARP8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PARP8

    Export disorders for PARP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PARP8 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with PARP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The PARP superfamily. (PubMed id 15273990)1, 3 AmAc J.C....de Murcia G. (Bioessays 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    5. Genetics of callous-unemotional behavior in children. (PubMed id 23874384)1 Viding E....Plomin R. (PLoS ONE 2013)
    6. Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. (PubMed id 22685421)1 Fan Q....Saw S.M. (PLoS Genet. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (Trends Biochem. Sci. 2010)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79668 HGNC: 26124 AceView: PARP8 Ensembl:ENSG00000151883 euGenes: HUgn79668
    ECgene: PARP8 H-InvDB: PARP8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PARP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PARP8 gene:
    Search GeneIP for patents involving PARP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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