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Aliases for PARP6 Gene

Aliases for PARP6 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 6 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 17 3 4
  • EC 2.4.2.30 4 58
  • ARTD17 3 4
  • PARP-6 3 4
  • Poly [ADP-Ribose] Polymerase 6 3
  • PARP-6-B1 3
  • PARP-6-C 3
  • PART17 3

External Ids for PARP6 Gene

Previous GeneCards Identifiers for PARP6 Gene

  • GC15M070320
  • GC15M072533
  • GC15M049364

Summaries for PARP6 Gene

GeneCards Summary for PARP6 Gene

PARP6 (Poly(ADP-Ribose) Polymerase Family Member 6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP8.

Tocris Summary for PARP6 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Additional gene information for PARP6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP6 Gene

Genomics for PARP6 Gene

Regulatory Elements for PARP6 Gene

Enhancers for PARP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H072471 1.4 ENCODE dbSUPER 31.7 -201.0 -200963 5 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ENSG00000261187 ARIH1 TMEM202-AS1 PARP6 HEXA BBS4 MYO9A ENSG00000260672 LOC105370887 CELF6
GH15H072781 2 FANTOM5 Ensembl ENCODE dbSUPER 21 -511.7 -511679 5 MLX ZFP64 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF610 GLIS1 ENSG00000261187 MYO9A ARIH1 BBS4 PARP6 TMEM202 LOC105370890 ENSG00000260672 CELF6 ADPGK
GH15H072116 1.4 Ensembl ENCODE 28.8 +154.8 154764 3 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF416 ZNF143 ENSG00000261187 CELF6 PARP6 MYO9A RPL17P39 BBS4 ARIH1 TMEM202-AS1 ENSG00000260672 HEXA
GH15H072194 1.5 Ensembl ENCODE dbSUPER 25.9 +73.5 73480 9 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 GLIS2 ZNF207 ZNF143 RUNX3 PARP6 ENSG00000261187 CELF6 PKM TMEM202-AS1 ARIH1 ENSG00000260672 RPL17P39 LOC105370887 ENSG00000260534
GH15H072181 1.5 Ensembl ENCODE dbSUPER 20.9 +89.7 89683 3 FOXA2 ZNF133 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZNF121 GLIS2 ZNF143 PARP6 ENSG00000261187 TMEM202 BBS4 RPL17P39 PKM ARIH1 MYO9A HEXA GRAMD2A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP6 on UCSC Golden Path with GeneCards custom track

Promoters for PARP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079026 499 1401 HDGF ARNT SIN3A ZNF2 ZBTB7B YY1 ZNF143 DEK SP3 REST

Genomic Location for PARP6 Gene

Chromosome:
15
Start:
72,241,181 bp from pter
End:
72,272,999 bp from pter
Size:
31,819 bases
Orientation:
Minus strand

Genomic View for PARP6 Gene

Genes around PARP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP6 Gene

Proteins for PARP6 Gene

  • Protein details for PARP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NL67-PARP6_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 6
    Protein Accession:
    Q2NL67
    Secondary Accessions:
    • Q9H7C5
    • Q9H9X6
    • Q9HAF3
    • Q9NPS6
    • Q9UFG4

    Protein attributes for PARP6 Gene

    Size:
    630 amino acids
    Molecular mass:
    71115 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB59261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP6 Gene

Selected DME Specific Peptides for PARP6 Gene

Q2NL67:
  • DHVCTRFFFVYEDGQVGDANINTQ
  • GSTFAFHGSHIENWHSILRNGLV
  • IFEPYPSVVDP
  • SIREMTQ
  • HQFLLLSSPPAKE
  • SSISFGYSGM
  • LNEYCVVCDE
  • DPLAHPLLQW
  • CIALCEVITS
  • YLEIKKQMDK
  • ISSNRSHIVKLP

Post-translational modifications for PARP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP6 Gene

Gene Families for PARP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP6 Gene

Suggested Antigen Peptide Sequences for PARP6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP6: view

No data available for UniProtKB/Swiss-Prot for PARP6 Gene

Function for PARP6 Gene

Molecular function for PARP6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP6 Gene

Phenotypes From GWAS Catalog for PARP6 Gene

Gene Ontology (GO) - Molecular Function for PARP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP6: view
genes like me logo Genes that share phenotypes with PARP6: view

Animal Model Products

CRISPR Products

miRNA for PARP6 Gene

miRTarBase miRNAs that target PARP6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARP6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP6 Gene

Localization for PARP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP6 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PARP6 Gene

Pathways & Interactions for PARP6 Gene

genes like me logo Genes that share pathways with PARP6: view

Gene Ontology (GO) - Biological Process for PARP6 Gene

None

No data available for SIGNOR curated interactions for PARP6 Gene

Drugs & Compounds for PARP6 Gene

(11) Drugs for PARP6 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 937,941
AG-14361 Pharma Potent PARP1 inhibitor 0
Iniparib (BSI-201) Pharma PARP1 inhibitor,intravenously adminsitered 0
INO-1001 Pharma Potent PARP inhibitor 0
ME0328 Pharma PARP inhibitor,potent and selective 0

(1) Additional Compounds for PARP6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP6 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3

(5) ApexBio Compounds for PARP6 Gene

Compound Action Cas Number
AG-14361 Potent PARP1 inhibitor 328543-09-5
Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered 160003-66-7
INO-1001 Potent PARP inhibitor 3544-24-9
ME0328 PARP inhibitor,potent and selective 1445251-22-8
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
genes like me logo Genes that share compounds with PARP6: view

Drug Products

Transcripts for PARP6 Gene

Unigene Clusters for PARP6 Gene

Poly (ADP-ribose) polymerase family, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARP6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PARP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - -
SP15:
SP16: - -
SP17: - -
SP18:
SP19:

ExUns: 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ·
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - - - - - - - - - - - - - - - -
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PARP6 Gene

GeneLoc Exon Structure for
PARP6
ECgene alternative splicing isoforms for
PARP6

Expression for PARP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP6 Gene



NURSA nuclear receptor signaling pathways regulating expression of PARP6 Gene:

PARP6

SOURCE GeneReport for Unigene cluster for PARP6 Gene:

Hs.270244

Evidence on tissue expression from TISSUES for PARP6 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with PARP6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP6 Gene

Orthologs for PARP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP6 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PARP6 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP6 33 34
  • 96.61 (n)
chimpanzee
(Pan troglodytes)
Mammalia PARP6 33 34
  • 95.88 (n)
mouse
(Mus musculus)
Mammalia Parp6 33 16 34
  • 94.81 (n)
rat
(Rattus norvegicus)
Mammalia Parp6 33
  • 94.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PARP6 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARP6 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP6 33 34
  • 84.03 (n)
lizard
(Anolis carolinensis)
Reptilia PARP6 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp6 33
  • 77.18 (n)
Str.11258 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17912 33
zebrafish
(Danio rerio)
Actinopterygii PARP6 (3 of 4) 34
  • 96 (a)
OneToMany
PARP6 (4 of 4) 34
  • 80 (a)
OneToMany
parp6a 34
  • 80 (a)
OneToMany
parp6b 34
  • 80 (a)
OneToMany
LOC100329514 33
  • 73.5 (n)
Dr.15239 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6240 33
Species where no ortholog for PARP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP6 Gene

ENSEMBL:
Gene Tree for PARP6 (if available)
TreeFam:
Gene Tree for PARP6 (if available)

Paralogs for PARP6 Gene

Paralogs for PARP6 Gene

genes like me logo Genes that share paralogs with PARP6: view

Variants for PARP6 Gene

Sequence variations from dbSNP and Humsavar for PARP6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000060414 -- 72,271,504(+) ATCAC(A/C)AACAC intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000182470 -- 72,244,705(+) TGGAA(C/T)ATTTG intron-variant
rs1000228961 -- 72,258,976(+) GGCAT(A/G)TTTAT intron-variant
rs1000281 -- 72,261,081(+) TAATA(C/T)TGACT intron-variant
rs1000486002 -- 72,254,087(+) GAAGA(G/T)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP6 Gene

Variant ID Type Subtype PubMed ID
nsv1601 CNV deletion 18451855

Variation tolerance for PARP6 Gene

Residual Variation Intolerance Score: 8.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP6 Gene

Disorders for PARP6 Gene

Relevant External Links for PARP6

Genetic Association Database (GAD)
PARP6
Human Genome Epidemiology (HuGE) Navigator
PARP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP6

No disorders were found for PARP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP6 Gene

Publications for PARP6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3 60
  5. Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells. (PMID: 28260087) Wang H … Zhu X (Oncology reports 2017) 3 60

Products for PARP6 Gene

Sources for PARP6 Gene

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