Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PARP6 Gene

Aliases for PARP6 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 6 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 17 3 4
  • EC 2.4.2.30 4 61
  • ARTD17 3 4
  • PARP-6 3 4
  • Poly [ADP-Ribose] Polymerase 6 3
  • PARP-6-B1 3
  • PARP-6-C 3
  • PART17 3

External Ids for PARP6 Gene

Previous GeneCards Identifiers for PARP6 Gene

  • GC15M070320
  • GC15M072533
  • GC15M049364

Summaries for PARP6 Gene

GeneCards Summary for PARP6 Gene

PARP6 (Poly(ADP-Ribose) Polymerase Family Member 6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP8.

Tocris Summary for PARP6 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP6 Gene

Genomics for PARP6 Gene

Regulatory Elements for PARP6 Gene

Enhancers for PARP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F072236 1.3 Ensembl ENCODE 18.5 +35.5 35452 2.7 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF121 KLF7 FOS ZNF263 SP3 PARP6 ARIH1 GRAMD2 LOC105370887 LOC105370888 PKM
GH15F072194 1.3 Ensembl ENCODE 15.5 +73.5 73480 9.6 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 ENSG00000261187 PARP6 BBS4 PKM LOC105370888 ARIH1 ENSG00000260672 RPL17P39 MYO9A HEXA
GH15F072179 1.1 Ensembl ENCODE 14.5 +92.8 92814 2.0 YBX3 HDGF ATF1 YBX1 RAD21 RARA ZNF335 ZNF766 FOS SMARCA5 PARP6 PKM ENSG00000260037 HEXA GRAMD2 ENSG00000260173
GH15F072181 1.4 Ensembl ENCODE 10.1 +89.7 89683 3.4 MLX CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC ENSG00000261187 BBS4 RPL17P39 TMEM202 HEXA ARIH1 PKM PARP6 LOC105370887 GRAMD2
GH15F072218 0.8 Ensembl ENCODE 15.9 +53.0 53022 3.2 ZNF362 POLR2A WRNIP1 WT1 PRDM1 ZBTB1 PARP6 GRAMD2 MYO9A PKM
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP6 on UCSC Golden Path with GeneCards custom track

Promoters for PARP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022032 499 1801 HDGF CREB3L1 WRNIP1 SIN3A ZNF2 ZNF143 DEK ZNF263 SP3 REST

Genomic Location for PARP6 Gene

Chromosome:
15
Start:
72,241,181 bp from pter
End:
72,272,999 bp from pter
Size:
31,819 bases
Orientation:
Minus strand

Genomic View for PARP6 Gene

Genes around PARP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP6 Gene

Proteins for PARP6 Gene

  • Protein details for PARP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NL67-PARP6_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 6
    Protein Accession:
    Q2NL67
    Secondary Accessions:
    • Q9H7C5
    • Q9H9X6
    • Q9HAF3
    • Q9NPS6
    • Q9UFG4

    Protein attributes for PARP6 Gene

    Size:
    630 amino acids
    Molecular mass:
    71115 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB59261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP6 Gene

Selected DME Specific Peptides for PARP6 Gene

Q2NL67:
  • DHVCTRFFFVYEDGQVGDANINTQ
  • GSTFAFHGSHIENWHSILRNGLV
  • IFEPYPSVVDP
  • SIREMTQ
  • HQFLLLSSPPAKE
  • SSISFGYSGM
  • LNEYCVVCDE
  • DPLAHPLLQW
  • CIALCEVITS
  • YLEIKKQMDK
  • ISSNRSHIVKLP

Post-translational modifications for PARP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP6 Gene

Gene Families for PARP6 Gene

Protein Domains for PARP6 Gene

Suggested Antigen Peptide Sequences for PARP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q2NL67

UniProtKB/Swiss-Prot:

PARP6_HUMAN :
  • Contains 1 PARP catalytic domain.
Domain:
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP6: view

Function for PARP6 Gene

Molecular function for PARP6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP6 Gene

Gene Ontology (GO) - Molecular Function for PARP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP6: view
genes like me logo Genes that share phenotypes with PARP6: view

Animal Model Products

miRNA for PARP6 Gene

miRTarBase miRNAs that target PARP6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP6 Gene

Localization for PARP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP6 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PARP6 Gene

Pathways & Interactions for PARP6 Gene

genes like me logo Genes that share pathways with PARP6: view

Gene Ontology (GO) - Biological Process for PARP6 Gene

None

No data available for SIGNOR curated interactions for PARP6 Gene

Drugs & Compounds for PARP6 Gene

(11) Drugs for PARP6 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 902,906
AG-14361 Pharma Potent PARP1 inhibitor 0
Iniparib (BSI-201) Pharma PARP1 inhibitor,intravenously adminsitered 0
INO-1001 Pharma Potent PARP inhibitor 0
ME0328 Pharma PARP inhibitor,potent and selective 0

(1) Additional Compounds for PARP6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP6 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3

(5) ApexBio Compounds for PARP6 Gene

Compound Action Cas Number
AG-14361 Potent PARP1 inhibitor 328543-09-5
Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered 160003-66-7
INO-1001 Potent PARP inhibitor 3544-24-9
ME0328 PARP inhibitor,potent and selective 1445251-22-8
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
genes like me logo Genes that share compounds with PARP6: view

Transcripts for PARP6 Gene

Unigene Clusters for PARP6 Gene

Poly (ADP-ribose) polymerase family, member 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - -
SP15:
SP16: - -
SP17: - -
SP18:
SP19:

ExUns: 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ·
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - - - - - - - - - - - - - - - -
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PARP6 Gene

GeneLoc Exon Structure for
PARP6
ECgene alternative splicing isoforms for
PARP6

Expression for PARP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP6 Gene



NURSA nuclear receptor signaling pathways regulating expression of PARP6 Gene:

PARP6

SOURCE GeneReport for Unigene cluster for PARP6 Gene:

Hs.270244
genes like me logo Genes that share expression patterns with PARP6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PARP6 Gene

Orthologs for PARP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP6 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PARP6 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP6 34 35
  • 96.61 (n)
chimpanzee
(Pan troglodytes)
Mammalia PARP6 34 35
  • 95.88 (n)
mouse
(Mus musculus)
Mammalia Parp6 34 16 35
  • 94.81 (n)
rat
(Rattus norvegicus)
Mammalia Parp6 34
  • 94.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PARP6 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARP6 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP6 34 35
  • 84.03 (n)
lizard
(Anolis carolinensis)
Reptilia PARP6 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp6 34
  • 77.18 (n)
Str.11258 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17912 34
zebrafish
(Danio rerio)
Actinopterygii PARP6 (3 of 4) 35
  • 96 (a)
OneToMany
PARP6 (4 of 4) 35
  • 80 (a)
OneToMany
parp6a 35
  • 80 (a)
OneToMany
parp6b 35
  • 80 (a)
OneToMany
LOC100329514 34
  • 73.5 (n)
Dr.15239 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6240 34
Species where no ortholog for PARP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP6 Gene

ENSEMBL:
Gene Tree for PARP6 (if available)
TreeFam:
Gene Tree for PARP6 (if available)

Paralogs for PARP6 Gene

Paralogs for PARP6 Gene

genes like me logo Genes that share paralogs with PARP6: view

Variants for PARP6 Gene

Sequence variations from dbSNP and Humsavar for PARP6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000281 -- 72,261,081(+) TAATA(C/T)TGACT intron-variant
rs1035744 -- 72,274,274(-) GGATG(A/G)GAGAG upstream-variant-2KB
rs1044132 -- 72,241,410(-) TCCAT(C/T)TGCCC nc-transcript-variant, utr-variant-3-prime
rs1044144 -- 72,241,320(-) TGTAA(A/G)AGGTG nc-transcript-variant, utr-variant-3-prime
rs1044151 -- 72,241,274(-) ACATT(C/T)GGATG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PARP6 Gene

Variant ID Type Subtype PubMed ID
nsv1601 CNV deletion 18451855

Variation tolerance for PARP6 Gene

Residual Variation Intolerance Score: 8.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP6 Gene

Disorders for PARP6 Gene

Relevant External Links for PARP6

Genetic Association Database (GAD)
PARP6
Human Genome Epidemiology (HuGE) Navigator
PARP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP6

No disorders were found for PARP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP6 Gene

Publications for PARP6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3 64

Products for PARP6 Gene

Sources for PARP6 Gene

Content
Loading form....