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Aliases for PARP6 Gene

Aliases for PARP6 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 6 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 17 3 4
  • EC 2.4.2.30 4 63
  • ARTD17 3 4
  • PARP-6 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 6 3
  • PARP-6-B1 3
  • PARP-6-C 3
  • PART17 3

External Ids for PARP6 Gene

Previous GeneCards Identifiers for PARP6 Gene

  • GC15M070320
  • GC15M072533
  • GC15M049364

Summaries for PARP6 Gene

GeneCards Summary for PARP6 Gene

PARP6 (Poly(ADP-Ribose) Polymerase Family Member 6) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP8.

Tocris Summary for PARP6 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP6 Gene

Genomics for PARP6 Gene

Regulatory Elements for PARP6 Gene

Promoters for PARP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PARP6 Gene

Chromosome:
15
Start:
72,241,181 bp from pter
End:
72,272,999 bp from pter
Size:
31,819 bases
Orientation:
Minus strand

Genomic View for PARP6 Gene

Genes around PARP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP6 Gene

Proteins for PARP6 Gene

  • Protein details for PARP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NL67-PARP6_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 6
    Protein Accession:
    Q2NL67
    Secondary Accessions:
    • Q9H7C5
    • Q9H9X6
    • Q9HAF3
    • Q9NPS6
    • Q9UFG4

    Protein attributes for PARP6 Gene

    Size:
    630 amino acids
    Molecular mass:
    71115 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB59261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP6 Gene

Proteomics data for PARP6 Gene at MOPED

Post-translational modifications for PARP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP6 Gene

Gene Families for PARP6 Gene

Protein Domains for PARP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q2NL67

UniProtKB/Swiss-Prot:

PARP6_HUMAN :
  • Contains 1 PARP catalytic domain.
Domain:
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP6: view

Function for PARP6 Gene

Molecular function for PARP6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP6 Gene

genes like me logo Genes that share phenotypes with PARP6: view

Animal Model Products

miRNA for PARP6 Gene

miRTarBase miRNAs that target PARP6

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP6 Gene

Localization for PARP6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP6 Gene COMPARTMENTS Subcellular localization image for PARP6 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PARP6 Gene

Pathways & Interactions for PARP6 Gene

SuperPathways for PARP6 Gene

No Data Available

Interacting Proteins for PARP6 Gene

Gene Ontology (GO) - Biological Process for PARP6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PARP6 Gene

Drugs & Compounds for PARP6 Gene

(8) Drugs for PARP6 Gene - From: HMDB, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
INO-1001 Experimental Pharma Inhibition, Inhibitor Potent PARP inhibitor 0
Nicotinamide Experimental Nutra 353,361
NU1025 Experimental Pharma Potent PARP inhibitor 0
AG-14361 Pharma Potent PARP1 inhibitor 0
Iniparib (BSI-201) Pharma PARP1 inhibitor,intravenously adminsitered 0

(4) Additional Compounds for PARP6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7
genes like me logo Genes that share compounds with PARP6: view

Transcripts for PARP6 Gene

Unigene Clusters for PARP6 Gene

Poly (ADP-ribose) polymerase family, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - -
SP15:
SP16: - -
SP17: - -
SP18:
SP19:

ExUns: 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ·
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - - - - - - - - - - - - - - - -
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PARP6 Gene

GeneLoc Exon Structure for
PARP6
ECgene alternative splicing isoforms for
PARP6

Expression for PARP6 Gene

mRNA expression in normal human tissues for PARP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP6 Gene



SOURCE GeneReport for Unigene cluster for PARP6 Gene Hs.270244

genes like me logo Genes that share expression patterns with PARP6: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PARP6 Gene

Orthologs for PARP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP6 35
  • 95.88 (n)
  • 94.7 (a)
PARP6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARP6 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP6 36
  • 84 (a)
OneToOne
PARP6 35
  • 96.61 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Parp6 36
  • 99 (a)
OneToOne
Parp6 35
  • 94.81 (n)
  • 99.68 (a)
Parp6 16
oppossum
(Monodelphis domestica)
Mammalia PARP6 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP6 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp6 35
  • 94.23 (n)
  • 99.21 (a)
chicken
(Gallus gallus)
Aves PARP6 36
  • 73 (a)
OneToOne
PARP6 35
  • 84.03 (n)
  • 95.15 (a)
lizard
(Anolis carolinensis)
Reptilia PARP6 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17912 35
tropical clawed frog
(Silurana tropicalis)
Amphibia parp6 35
  • 77.18 (n)
  • 88.34 (a)
Str.11258 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6240 35
zebrafish
(Danio rerio)
Actinopterygii PARP6 (3 of 4) 36
  • 96 (a)
OneToMany
PARP6 (4 of 4) 36
  • 80 (a)
OneToMany
parp6a 36
  • 80 (a)
OneToMany
parp6b 36
  • 80 (a)
OneToMany
Dr.15239 35
LOC100329514 35
  • 73.5 (n)
  • 79.51 (a)
Species with no ortholog for PARP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP6 Gene

ENSEMBL:
Gene Tree for PARP6 (if available)
TreeFam:
Gene Tree for PARP6 (if available)

Paralogs for PARP6 Gene

Paralogs for PARP6 Gene

genes like me logo Genes that share paralogs with PARP6: view

Variants for PARP6 Gene

Sequence variations from dbSNP and Humsavar for PARP6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs713048 -- 72,250,743(+) TGACT(A/G)GTTGA intron-variant
rs714808 -- 72,251,055(+) TTAAC(C/T)CCACA intron-variant
rs1044132 -- 72,241,410(-) TCCAT(C/T)TGCCC nc-transcript-variant, utr-variant-3-prime
rs1044144 -- 72,241,320(-) TGTAA(A/G)AGGTG nc-transcript-variant, utr-variant-3-prime
rs1044151 -- 72,241,274(-) ACATT(C/T)GGATG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PARP6 Gene

Variant ID Type Subtype PubMed ID
nsv1601 CNV Loss 18451855

Variation tolerance for PARP6 Gene

Residual Variation Intolerance Score: 8.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP6 Gene

HapMap Linkage Disequilibrium report
PARP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP6 Gene

Disorders for PARP6 Gene

Relevant External Links for PARP6

Genetic Association Database (GAD)
PARP6
Human Genome Epidemiology (HuGE) Navigator
PARP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP6

No disorders were found for PARP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP6 Gene

Publications for PARP6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3
  3. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3
  4. PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development. (PMID: 23042038) Tuncel H. … Shimamoto F. (Int. J. Oncol. 2012) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PARP6 Gene

Sources for PARP6 Gene

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