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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PARP4 Gene

protein-coding   GIFtS: 63
GCID: GC13M024995

poly (ADP-ribose) polymerase family, member 4

(Previous name: ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like...)
(Previous symbol: ADPRTL1)
 Explore 4 diseases affiliated with
PARP4 via our new
 Human Malady Compendium 
Biological research products
for PARP4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Poly (ADP-Ribose) Polymerase Family, Member 41 2     ADP-Ribosyltransferase Diphtheria Toxin-Like 42 3
ADPRTL11 2 3 5     PARP-Related/IalphaI-Related H5/Proline-Rich2 3
VPARP1 2 3 5     KIAA01773 5
VAULT31 2     I-Alpha-I-Related1
VWA5C1 2     PARP-Related1
ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 11 2     H5 Proline-Rich2
P1931     Poly [ADP-Ribose] Polymerase 42
Vault Poly(ADP-Ribose) Polymerase2 3     Poly(ADP-Ribose) Synthetase2
193 KDa Vault Protein2 3     Poly(ADP-Ribosyl)Transferase-Like 12
ARTD42 3     Vault Protein, 193-KDa2
PARP-42 3     Von Willebrand Factor A Domain Containing 5C2
PARPL2 3     EC 2.4.2.303
PH5P2 3     

External Ids:    HGNC: 2711   Entrez Gene: 1432   Ensembl: ENSG000001026997   OMIM: 6075195   UniProtKB: Q9UKK33   

Export aliases for PARP4 gene to outside databases

Previous GC identifers: GC13M023893 GC13M005807


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PARP4:
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation
reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks
an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase.
Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors
such as protein-protein interaction mediated by the extensive carboxyl terminus. (provided by RefSeq, Jul 2008)

summary for PARP4:
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the
addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to
glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain
polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,
stroke and cardiovascular disease.

Gene Wiki entry for PARP4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PARP4 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   E47   STAT2   Hand1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PARP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q11

PARP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARP4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M024995:  view genomic region     (about GC identifiers)

Start:
24,995,064 bp from pter      End:
25,086,948 bp from pter
Size:
91,885 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PARP4_HUMAN, Q9UKK3 (See protein sequence)
Recommended Name: Poly [ADP-ribose] polymerase 4  
Size: 1724 amino acids; 192595 Da
Subunit: Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs
(vRNAs). Binds to MVP. Associates with TEP1
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Also found in the nucleus, associated
with mitotic spindles
Sequence caution: Sequence=BAA11494.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O75903 Q14682 Q5QNZ9 Q9H1M6

Explore the universe of human proteins at neXtProt for PARP4: NX_Q9UKK3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKK3

  • PARP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006428.2  
    ENSEMBL proteins: 
     ENSP00000371419  

    Human Recombinant Protein Products: 
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    Novus Biologicals PARP4 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PARP4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10644454
    GO:0005737cytoplasm IDA--
    GO:0005876spindle microtubule IDA10477748
    GO:0030529ribonucleoprotein complex NAS11479319


    PARP4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PARP4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR004102 Poly(ADP-ribose)pol_reg_dom
     IPR013694 VIT
     IPR012317 Poly(ADP-ribose)pol_cat_dom
     IPR001357 BRCT_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9UKK3

    ProtoNet protein and cluster: Q9UKK3

    2 Blocks protein families:
    IPB001357 BRCT domain
    IPB002035 Von Willebrand factor type A domain signature


    UniProtKB/Swiss-Prot: PARP4_HUMAN, Q9UKK3
    Similarity: Contains 1 BRCT domain
    Similarity: Contains 1 PARP alpha-helical domain
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PARP4_HUMAN, Q9UKK3
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

    Enzyme Number (IUBMB): EC 2.4.2.301

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPARP4 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10100603
    GO:0003950NAD+ ADP-ribosyltransferase activity NAS10644454
    GO:0005515protein binding IPI--
    GO:0019899enzyme binding IDA15169895


    PARP4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PARP4:
     Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-out Parp4tm1Leah for PARP4
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Parp4):
     normal 

    PARP4 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    NAD metabolism1.00
    NAD metabolism1.00
    2Resolution of Abasic Sites (AP sites)
    Base excision repair0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PARP4
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for PARP4
        NAD metabolism


    1         Kegg Pathway  (Kegg details for PARP4):
        Base excision repair


    PARP4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PARP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/593 Interacting proteins for PARP4 (Q9UKK31, 2, 3 ENSP000003714194) via UniProtKB, MINT, STRING, and/or I2D (see all 593)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MVPQ147642, 3, ENSP000003499774MINT-7945693 I2D: score=3 STRING: ENSP00000349977
    TUBGCP3Q96CW52, ENSP000002619654MINT-7945693 STRING: ENSP00000261965
    TBL1XR1Q9BZK72, ENSP000004055744MINT-7945693 STRING: ENSP00000405574
    TUBG1P232582, ENSP000002514134MINT-7945693 STRING: ENSP00000251413
    AURKAO149652, ENSP000002169114MINT-7945693 STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair NAS12101391
    GO:0006464cellular protein modification process IDA10477748
    GO:0006471protein ADP-ribosylation NAS10644454
    GO:0006810transport NAS11855821
    GO:0006954inflammatory response IMP12123754


    PARP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PARP4 for compounds           About GeneDecksing

    EMD Millipore small molecules for PARP4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PARP4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DR 2313Potent PARP inhibitor[284028-90-6]
    3-AminobenzamidePARP inhibitor[3544-24-9]
    4-HQNPARP inhibitor[491-36-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    3 HMDB Compounds for PARP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    1 Novoseek chemical compound relationship for PARP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 79.7 4 18759128 (1), 17593814 (1), 11085454 (1), 16563451 (1)

    Search CenterWatch for drugs/clinical trials and news about PARP4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PARP4 gene: 
    NM_006437.3  

    Unigene Cluster for PARP4:

    Poly (ADP-ribose) polymerase family, member 4
    Hs.117825  [show with all ESTs]
    Unigene Representative Sequence: AF158255
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381989(uc001upl.3 uc010tdc.2) ENST00000484989 ENST00000480576


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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARP4
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    Additional cDNA sequence: 

    AF057160.1 AF158255.1 AK304399.1 BC017815.1 D79999.2 

    11 DOTS entries:

    DT.418112  DT.86855576  DT.100649013  DT.120791206  DT.430685  DT.86857326  DT.99927889  DT.101977075 
    DT.418114  DT.95343971  DT.95349193 

    24/230 AceView cDNA sequences (see all 230):

    AI804459 AA243734 AW008359 AI309233 CA311113 AA127973 BE162965 BX436890 
    BM974971 BU617902 CA430941 CA308288 AA346555 T27112 AA412040 AI589305 
    BQ001340 AI357240 BM667043 AI537652 BE646392 BM680238 AW135431 CD370468 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTCTATGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PARP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PARP4

    SOURCE GeneReport for Unigene cluster: Hs.117825

    UniProtKB/Swiss-Prot: PARP4_HUMAN, Q9UKK3
    Tissue specificity: Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung,
    liver, skeletal muscle, spleen, leukocytes and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including PARP4: 
              Cancer Drug Targets in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PARP4 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PARP41 poly (ADP-ribose) polymerase family, member 4 64.81(n)
    58.83(a)
      418958  NM_001171164.1  NP_001164635.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARP46
    --
    43(a)
    1 ↔ 1
    3(186938918-186997559)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-174k18.11 si:dkey-174k18.1 51.03(n)
    42.81(a)
      558045  XM_001921875.2  XP_001921910.2 


    ENSEMBL Gene Tree for PARP4 (if available)
    TreeFam Gene Tree for PARP4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PARP4 gene
    VWA5B12  VWA5A2  VWA5B22  

    PARP4 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for PARP4
    PGOHUM00000248509 PGOHUM00000248542 PGOHUM00000246200 PGOHUM00000233887


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2387 NCBI SNPs in PARP4 are shown (see all 2387    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812315301,2
    --24994644(+) CTGCAG/TTGAGG 1 -- ds50010--------
    rs128734611,2
    --24994668(+) ccacaA/C/Ttccag 1 -- ds50012NA 4
    rs1391258361,2
    --24994702(+) CTCTAA/CAACAA 1 -- ds50010--------
    rs95112441,2
    --24994726(+) ggcacA/Cgtggc 1 -- ds50010--------
    rs1128687021,2
    --24994763(+) GAGGCC/TGAGGC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs95112451,2
    C,H,--24994886(+) CCTAGC/TTACTC 1 -- ds50016Minor allele frequency- T:0.00NA WA CSA 11
    rs120211551,2
    C,--24994956(+) ATCACG/ATCATT 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs2011650441,2
    --24995023(+) AAAAA-/ATACATA 1 -- ds50010--------
    rs95112461,2
    C,F--24995024(+) AAAAAA/TACATA 1 -- ds50015Minor allele frequency- T:0.20NA WA CSA 10
    rs1468896431,2
    --24995055(+) GAGACA/CCAGAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PARP4 (24995064 - 25086948 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PARP4
         2 CNVs: 3006 8748

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PARP4 for disorders           About GeneDecksing

    OMIM gene information: 607519    OMIM disorders: --

    4 diseases for PARP4:    About MalaCards
    diphtheria    breast cancer    pulmonary disease    osteosarcoma

    3 Novoseek disease relationships for PARP4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 17.6 2 17593814 (2)
    breast cancer 5.93 1 17593814 (1)
    tumors 0 3 10706131 (1), 16204055 (1)

    Human Genome Epidemiology (HuGE) Navigator: PARP4 (7 documents)

    Export disorders for PARP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARP4 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with PARP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene (ADPRTL1) encoding a potential poly(ADP-ribosyl)transferase protein. (PubMed id 10644454)1, 2, 3, 9 Still I.H.... Cowell J.K. (1999)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    3. Vaults and telomerase share a common subunit, TEP1. (PubMed id 10551828)1, 2 Kickhoefer V.A....Rome L.H. (1999)
    4. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? (PubMed id 10100603)1, 2 Jean L....Salier J.P. (1999)
    5. The 193 kDa vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. (PubMed id 10477748)1, 2 Kickhoefer V.A.... Rome L.H. (1999)
    6. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (1996)
    7. Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. (PubMed id 15169895)1, 9 Liu Y....Harrington L. (2004)
    8. Up-regulation of vaults may be necessary but not sufficient for multidrug resistance. (PubMed id 11291045)1, 9 Siva A.C....Rome L.H. (2001)
    9. Multiple human vault RNAs. Expression and association with the vault complex. (PubMed id 11479319)1, 9 van Zon A....Wiemer E.A. (2001)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143 HGNC: 271 AceView: PARP4 Ensembl:ENSG00000102699 euGenes: HUgn143
    ECgene: PARP4 Kegg: 143 H-InvDB: PARP4

    (According to HUGE)
    About This Section
    HUGE: KIAA0177

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PARP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PARP4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PARP4 gene:
    Search GeneIP for patents involving PARP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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