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Aliases for PARP3 Gene

Aliases for PARP3 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 3 2 3 5
  • ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 3 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 3 3 4
  • NAD(+) ADP-Ribosyltransferase 3 3 4
  • Poly(ADP-Ribose) Synthetase-3 2 3
  • NAD+ ADP-Ribosyltransferase 3 2 3
  • Poly[ADP-Ribose] Synthase 3 3 4
  • PADPRT-3 3 4
  • ADPRTL3 3 4
  • ADPRT-3 3 4
  • ADPRT3 3 4
  • ARTD3 3 4
  • IRT1 3 4
  • ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 2 3
  • Poly [ADP-Ribose] Polymerase 3 3
  • Poly(ADP-Ribose) Polymerase 3 2
  • Poly[ADP-Ribose] Synthetase 3 3
  • EC 2.4.2.30 4
  • ADPRTL2 3
  • HPARP-3 4
  • PARP-3 4

External Ids for PARP3 Gene

Previous HGNC Symbols for PARP3 Gene

  • ADPRTL3

Summaries for PARP3 Gene

Entrez Gene Summary for PARP3 Gene

  • The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARP3 Gene

PARP3 (Poly(ADP-Ribose) Polymerase Family Member 3) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP2.

UniProtKB/Swiss-Prot for PARP3 Gene

  • Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Tocris Summary for PARP3 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP3 Gene

Additional gene information for PARP3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP3 Gene

Genomics for PARP3 Gene

Regulatory Elements for PARP3 Gene

Enhancers for PARP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H051980 1.4 ENCODE dbSUPER 7.6 +41.9 41918 6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 GPR62 PARP3 RPL29 ABHD14B
GH03H051940 1.1 ENCODE 9.6 +0.0 25 3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ABHD14A PARP3 RPL29 ENSG00000280422
GH03H051973 1.3 Ensembl ENCODE 7.6 +32.9 32854 3 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5 ZHX2 PARP3 NT5DC2 ABHD14A-ACY1 ACY1
GH03H051966 1.1 ENCODE dbSUPER 8.2 +25.7 25664 3 HDGF RB1 ARID4B TCF12 EGR1 SCRT2 EGR2 PAF1 ELF1 ZNF398 PARP3 ABHD14A GC03P051963
GH03H052215 1.4 Ensembl ENCODE dbSUPER 5.1 +276.0 276042 5 TBP HDGF PKNOX1 RB1 ARID4B ZNF2 RAD21 RARA YY1 SCRT2 GLYCTK PPM1M WDR82 MIR135A1 GLYCTK-AS1 DUSP7 TWF2 PARP3 SERBP1P3 ENSG00000280003
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP3 on UCSC Golden Path with GeneCards custom track

Promoters for PARP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152454 -387 1401 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207

Genomic Location for PARP3 Gene

Chromosome:
3
Start:
51,942,287 bp from pter
End:
51,948,867 bp from pter
Size:
6,581 bases
Orientation:
Plus strand

Genomic View for PARP3 Gene

Genes around PARP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP3 Gene

Proteins for PARP3 Gene

  • Protein details for PARP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F1-PARP3_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 3
    Protein Accession:
    Q9Y6F1
    Secondary Accessions:
    • Q8NER9
    • Q96CG2
    • Q9UG81

    Protein attributes for PARP3 Gene

    Size:
    533 amino acids
    Molecular mass:
    60070 Da
    Quaternary structure:
    • Interacts with PRKDC and PARP1. Interacts with XRCC5; the interaction is dependent on nucleic acids. Interacts with XRCC6; the interaction is dependent on nucleic acids. Interacts with EZH2, HDAC1, HDAC2, SUZ12, YY1, LRIG3 and LIG4.

    Three dimensional structures from OCA and Proteopedia for PARP3 Gene

    Alternative splice isoforms for PARP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP3 Gene

Post-translational modifications for PARP3 Gene

No data available for DME Specific Peptides for PARP3 Gene

Domains & Families for PARP3 Gene

Gene Families for PARP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PARP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6F1

UniProtKB/Swiss-Prot:

PARP3_HUMAN :
  • According to PubMed:10329013, the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.
Domain:
  • According to PubMed:10329013, the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.
genes like me logo Genes that share domains with PARP3: view

Function for PARP3 Gene

Molecular function for PARP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Enzyme Numbers (IUBMB) for PARP3 Gene

Gene Ontology (GO) - Molecular Function for PARP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 10338144
GO:0003910 DNA ligase (ATP) activity IBA --
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA,IEA 21211721
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP3: view
genes like me logo Genes that share phenotypes with PARP3: view

Animal Models for PARP3 Gene

MGI Knock Outs for PARP3:

Animal Model Products

CRISPR Products

miRNA for PARP3 Gene

miRTarBase miRNAs that target PARP3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP3 Gene

Localization for PARP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP3 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with PARP3: view

Pathways & Interactions for PARP3 Gene

genes like me logo Genes that share pathways with PARP3: view

Pathways by source for PARP3 Gene

1 Sino Biological pathway for PARP3 Gene
3 KEGG pathways for PARP3 Gene
1 GeneGo (Thomson Reuters) pathway for PARP3 Gene

Gene Ontology (GO) - Biological Process for PARP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IMP 21270334
GO:0006273 lagging strand elongation IBA --
GO:0006281 DNA repair TAS 7260241
GO:0006302 double-strand break repair IMP,IEA 21211721
GO:0006471 protein ADP-ribosylation IEA,IDA 21270334
genes like me logo Genes that share ontologies with PARP3: view

No data available for SIGNOR curated interactions for PARP3 Gene

Drugs & Compounds for PARP3 Gene

(15) Drugs for PARP3 Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rucaparib Approved, Investigational Pharma Target, antagonist PARP inhibitor, PARP Inhibitors, Other 16
Olaparib Approved Pharma Target, inhibitor PARP inhibitor, PARP Inhibitors, Other, Poly(ADPRIBOSE) polymerase (PARP) inhibitors 151
Lynparza Approved December 2014 Pharma 0
Nicotinamide Approved Nutra 937,941
2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one Experimental Pharma Target 0

(2) Additional Compounds for PARP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP3 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3

(2) ApexBio Compounds for PARP3 Gene

Compound Action Cas Number
NU 1025 PARP inhibitor,potent and novel 90417-38-2
PJ34 hydrochloride PARP inhibitor,potent and cell-permeable 344458-15-7
genes like me logo Genes that share compounds with PARP3: view

Drug Products

Transcripts for PARP3 Gene

Unigene Clusters for PARP3 Gene

Poly (ADP-ribose) polymerase family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PARP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for PARP3 Gene

GeneLoc Exon Structure for
PARP3
ECgene alternative splicing isoforms for
PARP3

Expression for PARP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP3 Gene

Protein differential expression in normal tissues from HIPED for PARP3 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARP3 Gene



Protein tissue co-expression partners for PARP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PARP3 Gene:

PARP3

SOURCE GeneReport for Unigene cluster for PARP3 Gene:

Hs.271742

mRNA Expression by UniProt/SwissProt for PARP3 Gene:

Q9Y6F1-PARP3_HUMAN
Tissue specificity: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

Evidence on tissue expression from TISSUES for PARP3 Gene

  • Kidney(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PARP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP3 Gene

Orthologs for PARP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PARP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP3 33 34
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia PARP3 33 34
  • 86.13 (n)
cow
(Bos Taurus)
Mammalia PARP3 33 34
  • 82.87 (n)
mouse
(Mus musculus)
Mammalia Parp3 33 16 34
  • 82.42 (n)
rat
(Rattus norvegicus)
Mammalia Parp3 33
  • 81.88 (n)
oppossum
(Monodelphis domestica)
Mammalia PARP3 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP3 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP3 33 34
  • 68.26 (n)
lizard
(Anolis carolinensis)
Reptilia PARP3 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp3 33
  • 64.11 (n)
Str.15161 33
zebrafish
(Danio rerio)
Actinopterygii parp3 33 34
  • 59.82 (n)
zgc66157 33
worm
(Caenorhabditis elegans)
Secernentea Y75B7B.2 34
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 9 (a)
OneToOne
Species where no ortholog for PARP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARP3 Gene

ENSEMBL:
Gene Tree for PARP3 (if available)
TreeFam:
Gene Tree for PARP3 (if available)

Paralogs for PARP3 Gene

Paralogs for PARP3 Gene

(1) SIMAP similar genes for PARP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PARP3: view

Variants for PARP3 Gene

Sequence variations from dbSNP and Humsavar for PARP3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000590171 -- 51,948,607(+) TAGTC(A/C)CCATG utr-variant-3-prime
rs1001031386 -- 51,940,491(+) ATCTA(C/T)ATGCA intron-variant, upstream-variant-2KB
rs1001420596 -- 51,945,679(+) TATCA(A/G)TGGGC intron-variant
rs1001556641 -- 51,943,264(+) CTGTG(C/T)TGGCC intron-variant, upstream-variant-2KB
rs1001632740 -- 51,948,810(+) CAGCA(G/T)AATGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PARP3 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv508922 CNV insertion 20534489
nsv520211 CNV gain 19592680
nsv590280 CNV loss 21841781
nsv954857 CNV deletion 24416366

Variation tolerance for PARP3 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP3 Gene

Disorders for PARP3 Gene

Relevant External Links for PARP3

Genetic Association Database (GAD)
PARP3
Human Genome Epidemiology (HuGE) Navigator
PARP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP3

No disorders were found for PARP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP3 Gene

Publications for PARP3 Gene

  1. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. (PMID: 10329013) Johansson M (Genomics 1999) 2 3 4 22 60
  2. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression. (PMID: 12640039) Augustin A … De Murcia G (Journal of cell science 2003) 3 4 22 60
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Genetic variation in the base excision repair pathway and bladder cancer risk. (PMID: 17203305) Figueroa JD … García-Closas M (Human genetics 2007) 3 45 60

Products for PARP3 Gene

Sources for PARP3 Gene

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