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Aliases for PARP2 Gene

Aliases for PARP2 Gene

  • Poly (ADP-Ribose) Polymerase 2 2 3
  • ADP-Ribosyltransferase (NAD+; Poly(ADP-Ribose) Polymerase)-Like 2 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 2 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 2 2 3
  • NAD(+) ADP-Ribosyltransferase 2 3 4
  • Poly[ADP-Ribose] Synthase 2 3 4
  • EC 2.4.2.30 4 63
  • PADPRT-2 3 4
  • ADPRTL2 3 4
  • ADPRT-2 3 4
  • HPARP-2 3 4
  • ADPRT2 3 4
  • PARP-2 3 4
  • ARTD2 3 4
  • Poly (ADP-Ribosyl) Transferase-Like 2 3
  • Poly[ADP-Ribose] Synthetase 2 3
  • ADPRTL3 3

External Ids for PARP2 Gene

Previous HGNC Symbols for PARP2 Gene

  • ADPRTL2

Previous GeneCards Identifiers for PARP2 Gene

  • GC14P019881
  • GC14P020811
  • GC14P000933

Summaries for PARP2 Gene

Entrez Gene Summary for PARP2 Gene

  • This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARP2 Gene

PARP2 (Poly (ADP-Ribose) Polymerase 2) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and NAD metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP3.

UniProtKB/Swiss-Prot for PARP2 Gene

  • Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks

Tocris Summary for PARP2 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP2 Gene

Genomics for PARP2 Gene

Regulatory Elements for PARP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PARP2 Gene

Chromosome:
14
Start:
20,343,582 bp from pter
End:
20,357,910 bp from pter
Size:
14,329 bases
Orientation:
Plus strand

Genomic View for PARP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP2 Gene

Proteins for PARP2 Gene

  • Protein details for PARP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGN5-PARP2_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 2
    Protein Accession:
    Q9UGN5
    Secondary Accessions:
    • Q8TEU4
    • Q9NUV2
    • Q9UMR4
    • Q9Y6C8

    Protein attributes for PARP2 Gene

    Size:
    583 amino acids
    Molecular mass:
    66206 Da
    Quaternary structure:
    • Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1.
    SequenceCaution:
    • Sequence=AAD29857.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL77437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB41505.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP2 Gene

    Alternative splice isoforms for PARP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP2 Gene

Proteomics data for PARP2 Gene at MOPED

Selected DME Specific Peptides for PARP2 Gene

Post-translational modifications for PARP2 Gene

Other Protein References for PARP2 Gene

Antibody Products

Domains & Families for PARP2 Gene

Gene Families for PARP2 Gene

Suggested Antigen Peptide Sequences for PARP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGN5

UniProtKB/Swiss-Prot:

PARP2_HUMAN :
  • Contains 1 PARP alpha-helical domain.
Domain:
  • Contains 1 PARP alpha-helical domain.
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP2: view

Function for PARP2 Gene

Molecular function for PARP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks

Enzyme Numbers (IUBMB) for PARP2 Gene

Gene Ontology (GO) - Molecular Function for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003950 NAD+ ADP-ribosyltransferase activity IBA --
GO:0005515 protein binding IPI 21812934
genes like me logo Genes that share ontologies with PARP2: view
genes like me logo Genes that share phenotypes with PARP2: view

Animal Models for PARP2 Gene

MGI Knock Outs for PARP2:

Animal Model Products

miRNA for PARP2 Gene

miRTarBase miRNAs that target PARP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PARP2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PARP2 Gene

Localization for PARP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP2 Gene COMPARTMENTS Subcellular localization image for PARP2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 15615785
GO:0005730 nucleolus IDA 15615785
genes like me logo Genes that share ontologies with PARP2: view

Pathways & Interactions for PARP2 Gene

genes like me logo Genes that share pathways with PARP2: view

Pathways by source for PARP2 Gene

1 KEGG pathway for PARP2 Gene
1 GeneGo (Thomson Reuters) pathway for PARP2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS 7260241
GO:0006284 base-excision repair IEA --
GO:0006471 protein ADP-ribosylation IEA --
GO:0097191 extrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with PARP2: view

No data available for SIGNOR curated interactions for PARP2 Gene

Drugs & Compounds for PARP2 Gene

(23) Drugs for PARP2 Gene - From: DGIdb, HMDB, Tocris, ApexBio, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olaparib Approved Pharma inhibitor, Biomarker, other, Target PARP inhibitor, PARP Inhibitors, Other, Poly(ADPRIBOSE) polymerase (PARP) inhibitors 0
Lynparza Approved December 2014 Pharma 0
(2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium Experimental Pharma Target 0
Nicotinamide Experimental Nutra 332,340
NU1025 Experimental Pharma Potent PARP inhibitor 0

(9) Additional Compounds for PARP2 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7
adpribose
genes like me logo Genes that share compounds with PARP2: view

Drug Products

Transcripts for PARP2 Gene

Unigene Clusters for PARP2 Gene

Poly (ADP-ribose) polymerase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PARP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PARP2 Gene

GeneLoc Exon Structure for
PARP2
ECgene alternative splicing isoforms for
PARP2

Expression for PARP2 Gene

mRNA expression in normal human tissues for PARP2 Gene

Protein differential expression in normal tissues from HIPED for PARP2 Gene

This gene is overexpressed in Lung (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP2 Gene



SOURCE GeneReport for Unigene cluster for PARP2 Gene Hs.409412

mRNA Expression by UniProt/SwissProt for PARP2 Gene

Q9UGN5-PARP2_HUMAN
Tissue specificity: Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus
genes like me logo Genes that share expression patterns with PARP2: view

Protein tissue co-expression partners for PARP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PARP2 Gene

Orthologs for PARP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PARP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARP2 35
  • 89.97 (n)
  • 90.8 (a)
PARP2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP2 35
  • 87.38 (n)
  • 88.2 (a)
PARP2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp2 35
  • 86.67 (n)
  • 88.07 (a)
Parp2 16
Parp2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARP2 35
  • 99.66 (n)
  • 100 (a)
PARP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp2 35
  • 86.12 (n)
  • 86.97 (a)
oppossum
(Monodelphis domestica)
Mammalia PARP2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp2 35
  • 65.41 (n)
  • 69.18 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
parp2 35
  • 62.55 (n)
  • 63.11 (a)
parp2 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pme-2 36
  • 26 (a)
OneToMany
pme-5 36
  • 5 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PP 35
  • 51.99 (n)
  • 47.55 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.8751 35
rice
(Oryza sativa)
Liliopsida Os01g0351100 35
  • 52.53 (n)
  • 45.36 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3786 35
corn
(Zea mays)
Liliopsida Zm.164 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14032 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
CSA.5817 36
  • 27 (a)
OneToMany
Species with no ortholog for PARP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PARP2 Gene

ENSEMBL:
Gene Tree for PARP2 (if available)
TreeFam:
Gene Tree for PARP2 (if available)

Paralogs for PARP2 Gene

Paralogs for PARP2 Gene

(2) SIMAP similar genes for PARP2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PARP2 Gene

genes like me logo Genes that share paralogs with PARP2: view

Variants for PARP2 Gene

Sequence variations from dbSNP and Humsavar for PARP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2700 -- 20,357,806(-) TTTAA(G/T)ATCAA utr-variant-3-prime, downstream-variant-500B, nc-transcript-variant
rs878156 -- 20,356,700(+) TGAAA(C/T)TGAAC intron-variant
rs878157 -- 20,356,854(+) AATTC(C/T)TAAAG intron-variant
rs1128782 -- 20,357,408(+) TAGGT(C/T)AGTGT reference, stop-gained, intron-variant, utr-variant-3-prime, nc-transcript-variant
rs1713411 -- 20,354,336(-) ATGAG(A/C)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP2 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Variation tolerance for PARP2 Gene

Residual Variation Intolerance Score: 81.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP2 Gene

HapMap Linkage Disequilibrium report
PARP2
Human Gene Mutation Database (HGMD)
PARP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP2 Gene

Disorders for PARP2 Gene

Relevant External Links for PARP2

Genetic Association Database (GAD)
PARP2
Human Genome Epidemiology (HuGE) Navigator
PARP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP2
genes like me logo Genes that share disorders with PARP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP2 Gene

Publications for PARP2 Gene

  1. Toward specific functions of poly(ADP-ribose) polymerase-2. (PMID: 18353725) YAclamos J. … Dantzer F. (Trends Mol Med 2008) 2 23 67
  2. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. (PMID: 10329013) Johansson M. (Genomics 1999) 2 23 67
  3. Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice. (PMID: 20154718) NicolA!s L. … Yelamos J. (Oncogene 2010) 23 67
  4. Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry. (PMID: 20388209) Isabelle M. … Poirier G.G. (Proteome Sci 2010) 23 67
  5. PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. (PMID: 20064938) Loseva O. … Helleday T. (J. Biol. Chem. 2010) 23 67

Products for PARP2 Gene

Sources for PARP2 Gene

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