Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PARP2 Gene

Aliases for PARP2 Gene

  • Poly(ADP-Ribose) Polymerase 2 2 3 5
  • ADP-Ribosyltransferase (NAD+; Poly(ADP-Ribose) Polymerase)-Like 2 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 2 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 2 2 3
  • NAD(+) ADP-Ribosyltransferase 2 3 4
  • Poly[ADP-Ribose] Synthase 2 3 4
  • EC 2.4.2.30 4 61
  • PADPRT-2 3 4
  • ADPRTL2 3 4
  • ADPRT-2 3 4
  • HPARP-2 3 4
  • ADPRT2 3 4
  • PARP-2 3 4
  • ARTD2 3 4
  • Poly (ADP-Ribosyl) Transferase-Like 2 3
  • Poly [ADP-Ribose] Polymerase 2 3
  • Poly[ADP-Ribose] Synthetase 2 3
  • ADPRTL3 3

External Ids for PARP2 Gene

Previous HGNC Symbols for PARP2 Gene

  • ADPRTL2

Previous GeneCards Identifiers for PARP2 Gene

  • GC14P019881
  • GC14P020811
  • GC14P000933

Summaries for PARP2 Gene

Entrez Gene Summary for PARP2 Gene

  • This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARP2 Gene

PARP2 (Poly(ADP-Ribose) Polymerase 2) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP1.

UniProtKB/Swiss-Prot for PARP2 Gene

  • Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Tocris Summary for PARP2 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP2 Gene

Genomics for PARP2 Gene

Regulatory Elements for PARP2 Gene

Enhancers for PARP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020341 0.6 ENCODE 24.5 -0.4 -379 3.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 APEX1 TEP1 PARP2 TMEM55B ENSG00000258768 ENSG00000222489 ENSG00000258515 METTL17 RPPH1 CCNB1IP1
GH14F020679 1.2 FANTOM5 Ensembl ENCODE 21.4 +341.0 340951 9.8 CREB3L1 MLX ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC PPARGC1A SUPT16H METTL3 CHD8 ENSG00000258515 ENSG00000258768 PARP2 TMEM55B RNASE4 TEP1 OSGEP
GH14F020459 0.5 ENCODE 20 +117.9 117882 3.8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 PARP2 SUPT16H ENSG00000258768 ENSG00000258515 CHD8 OSGEP TMEM55B RNA5SP382 TEP1 TTC5
GH14F020652 1.1 Ensembl ENCODE 13.5 +309.7 309719 1.0 TBP ATF1 CBX3 SREBF2 INSM2 ZNF76 KLF17 DEAF1 SIN3A ZBTB40 METTL3 PARP2 CHD8 SUPT16H TMEM55B APEX1 ANG TOX4 TEP1 ENSG00000258515
GH14F020609 0.2 ENCODE 13.5 +266.3 266268 1.8 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 CHD8 SUPT16H METTL3 PARP2 TMEM55B APEX1 TOX4 TEP1 ENSG00000258515 ENSG00000258768
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PARP2 on UCSC Golden Path with GeneCards custom track

Promoters for PARP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001455819 -382 2801 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for PARP2 Gene

Chromosome:
14
Start:
20,343,582 bp from pter
End:
20,357,910 bp from pter
Size:
14,329 bases
Orientation:
Plus strand

Genomic View for PARP2 Gene

Genes around PARP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP2 Gene

Proteins for PARP2 Gene

  • Protein details for PARP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGN5-PARP2_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 2
    Protein Accession:
    Q9UGN5
    Secondary Accessions:
    • Q8TEU4
    • Q9NUV2
    • Q9UMR4
    • Q9Y6C8

    Protein attributes for PARP2 Gene

    Size:
    583 amino acids
    Molecular mass:
    66206 Da
    Quaternary structure:
    • Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1 (PubMed:20092359). Interacts weakly (via the PARP catalytic domain) with HPF1 (PubMed:27067600).
    SequenceCaution:
    • Sequence=AAD29857.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL77437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB41505.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP2 Gene

    Alternative splice isoforms for PARP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP2 Gene

Selected DME Specific Peptides for PARP2 Gene

Q9UGN5:
  • GKGIYFA
  • LLWHGSR
  • YNEYIVY
  • LLSEVALG

Post-translational modifications for PARP2 Gene

Domains & Families for PARP2 Gene

Gene Families for PARP2 Gene

Suggested Antigen Peptide Sequences for PARP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGN5

UniProtKB/Swiss-Prot:

PARP2_HUMAN :
  • Contains 1 PARP alpha-helical domain.
Domain:
  • Contains 1 PARP alpha-helical domain.
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP2: view

Function for PARP2 Gene

Molecular function for PARP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Enzyme Numbers (IUBMB) for PARP2 Gene

Gene Ontology (GO) - Molecular Function for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003910 DNA ligase (ATP) activity IBA --
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0005515 protein binding IPI 21812934
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PARP2: view
genes like me logo Genes that share phenotypes with PARP2: view

Animal Models for PARP2 Gene

MGI Knock Outs for PARP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PARP2

miRNA for PARP2 Gene

miRTarBase miRNAs that target PARP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP2 Gene

Localization for PARP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP2 Gene COMPARTMENTS Subcellular localization image for PARP2 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 15615785
GO:0005730 nucleolus IDA 15615785
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PARP2: view

Pathways & Interactions for PARP2 Gene

genes like me logo Genes that share pathways with PARP2: view

Pathways by source for PARP2 Gene

2 KEGG pathways for PARP2 Gene
1 GeneGo (Thomson Reuters) pathway for PARP2 Gene

Gene Ontology (GO) - Biological Process for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006273 lagging strand elongation IBA --
GO:0006281 DNA repair TAS 7260241
GO:0006284 base-excision repair IEA --
GO:0006471 protein ADP-ribosylation IEA --
GO:0051103 DNA ligation involved in DNA repair IBA --
genes like me logo Genes that share ontologies with PARP2: view

No data available for SIGNOR curated interactions for PARP2 Gene

Drugs & Compounds for PARP2 Gene

(39) Drugs for PARP2 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olaparib Approved Pharma inhibitor, Biomarker, other, Target PARP inhibitor, PARP Inhibitors, Other, Poly(ADPRIBOSE) polymerase (PARP) inhibitors 126
Rucaparib Approved, Investigational Pharma inhibitor, Biomarker, other PARP inhibitor, PARP Inhibitors, Other 14
Lynparza Approved December 2014 Pharma 0
Nicotinamide Approved Nutra 902,906
NU1025 Experimental Pharma PARP inhibitor,potent and novel 0

(5) Additional Compounds for PARP2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP2 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3

(22) ApexBio Compounds for PARP2 Gene

Compound Action Cas Number
4-HQN PARP inhibitor 491-36-1
A-966492 PARP-1/-2 inhibitor, highly potent 934162-61-5
ABT-888 (Veliparib) Potent PARP inhibitor 912444-00-9
AZD2461 Novel PARP inhibitor 1174043-16-3
BMN 673 Potent PARP inhibitor 1207456-01-6
BYK 49187 Potent PARP-1/PARP-2 inhibitor 163120-31-8
DR 2313 PARP inhibitor 284028-90-6
INO-1001 Potent PARP inhibitor 3544-24-9
JW 55 PARP domain inhibitor 664993-53-7
ME0328 PARP inhibitor,potent and selective 1445251-22-8
MK-4827 PARP-1/-2 inhibitor,potent and selective 1038915-60-4
MK-4827 hydrochloride PARP1/PARP2 inhibitor 1038915-64-8
MK-4827 Racemate 1038915-75-1
MK-4827 tosylate PARP1/PARP2 inhibitor 1038915-73-9
NU 1025 PARP inhibitor,potent and novel 90417-38-2
Olaparib (AZD2281, Ku-0059436) Potent PARP1/PARP2 inhibitor 763113-22-0
PJ34 hydrochloride PARP inhibitor,potent and cell-permeable 344458-15-7
Rucaparib (AG-014699,PF-01367338) Potent PARP inhibitor 459868-92-9
Rucaparib (free base) Potent PARP inhibitor 283173-50-2
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
Veliparib dihydrochloride PARP-1/PARP-2 inhibitor 912445-05-7
WIKI4 Inhibitor of Wnt/ß-Catenin signaling and tankyrase 838818-26-1
genes like me logo Genes that share compounds with PARP2: view

Drug Products

Transcripts for PARP2 Gene

Unigene Clusters for PARP2 Gene

Poly (ADP-ribose) polymerase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PARP2 Gene

GeneLoc Exon Structure for
PARP2
ECgene alternative splicing isoforms for
PARP2

Expression for PARP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP2 Gene

Protein differential expression in normal tissues from HIPED for PARP2 Gene

This gene is overexpressed in Lung (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP2 Gene



Protein tissue co-expression partners for PARP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP2 Gene:

PARP2

SOURCE GeneReport for Unigene cluster for PARP2 Gene:

Hs.409412

mRNA Expression by UniProt/SwissProt for PARP2 Gene:

Q9UGN5-PARP2_HUMAN
Tissue specificity: Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.
genes like me logo Genes that share expression patterns with PARP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PARP2 Gene

Orthologs for PARP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PARP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP2 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia PARP2 34 35
  • 89.97 (n)
dog
(Canis familiaris)
Mammalia PARP2 34 35
  • 87.38 (n)
mouse
(Mus musculus)
Mammalia Parp2 34 16 35
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Parp2 34
  • 86.12 (n)
oppossum
(Monodelphis domestica)
Mammalia PARP2 35
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp2 34
  • 65.41 (n)
zebrafish
(Danio rerio)
Actinopterygii parp2 34 35
  • 62.55 (n)
-- 34
worm
(Caenorhabditis elegans)
Secernentea pme-2 35
  • 26 (a)
OneToMany
pme-5 35
  • 5 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PP 34
  • 51.99 (n)
rice
(Oryza sativa)
Liliopsida Os01g0351100 34
  • 52.53 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.8751 34
wheat
(Triticum aestivum)
Liliopsida Ta.3786 34
corn
(Zea mays)
Liliopsida Zm.164 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
CSA.5817 35
  • 27 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14032 34
Species where no ortholog for PARP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PARP2 Gene

ENSEMBL:
Gene Tree for PARP2 (if available)
TreeFam:
Gene Tree for PARP2 (if available)

Paralogs for PARP2 Gene

Paralogs for PARP2 Gene

(2) SIMAP similar genes for PARP2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PARP2 Gene

genes like me logo Genes that share paralogs with PARP2: view

Variants for PARP2 Gene

Sequence variations from dbSNP and Humsavar for PARP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10131757 -- 20,351,191(+) AAAAt(A/T)ttttt intron-variant
rs10134548 -- 20,347,324(+) cacca(C/T)gcctt intron-variant
rs10151004 -- 20,353,535(+) actgc(A/G)gctgg intron-variant
rs10625250 -- 20,351,749(+) CGGTG(-/GCTC)ATGCC intron-variant
rs10625811 -- 20,357,162(+) GGAGT(-/TTCAC)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP2 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545
nsv1042025 CNV loss 25217958

Variation tolerance for PARP2 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP2 Gene

Human Gene Mutation Database (HGMD)
PARP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP2 Gene

Disorders for PARP2 Gene

Relevant External Links for PARP2

Genetic Association Database (GAD)
PARP2
Human Genome Epidemiology (HuGE) Navigator
PARP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP2

No disorders were found for PARP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP2 Gene

Publications for PARP2 Gene

  1. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. (PMID: 10329013) Johansson M. (Genomics 1999) 2 3 4 22 64
  2. LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest. (PMID: 19806447) Sakugawa N. … Sengoku K. (J. Assist. Reprod. Genet. 2009) 3 22 46 64
  3. Toward specific functions of poly(ADP-ribose) polymerase-2. (PMID: 18353725) YAclamos J. … Dantzer F. (Trends Mol Med 2008) 2 3 22 64
  4. PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. (PMID: 10364231) Ame J.-C. … de Murcia G.M. (J. Biol. Chem. 1999) 3 4 22 64
  5. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. (PMID: 27067600) Gibbs-Seymour I. … Ahel I. (Mol. Cell 2016) 3 4 64

Products for PARP2 Gene

Sources for PARP2 Gene

Content
Loading form....