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Aliases for PARP16 Gene

Aliases for PARP16 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 16 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 15 3 4
  • Poly [ADP-Ribose] Polymerase 16 3 4
  • C15orf30 3 4
  • PARP-16 3 4
  • ARTD15 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 16 3
  • Chromosome 15 Open Reading Frame 30 2
  • EC 2.4.2.30 4
  • PART15 3

External Ids for PARP16 Gene

Previous HGNC Symbols for PARP16 Gene

  • C15orf30

Previous GeneCards Identifiers for PARP16 Gene

  • GC15M063337
  • GC15M065550
  • GC15M042375

Summaries for PARP16 Gene

GeneCards Summary for PARP16 Gene

PARP16 (Poly(ADP-Ribose) Polymerase Family Member 16) is a Protein Coding gene. GO annotations related to this gene include kinase binding and protein serine/threonine kinase activator activity.

UniProtKB/Swiss-Prot for PARP16 Gene

  • Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

Tocris Summary for PARP16 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP16 Gene

Genomics for PARP16 Gene

Regulatory Elements for PARP16 Gene

Promoters for PARP16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARP16 on UCSC Golden Path with GeneCards custom track

Genomic Location for PARP16 Gene

Chromosome:
15
Start:
65,234,460 bp from pter
End:
65,300,618 bp from pter
Size:
66,159 bases
Orientation:
Minus strand

Genomic View for PARP16 Gene

Genes around PARP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP16 Gene

Proteins for PARP16 Gene

  • Protein details for PARP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Y8-PAR16_HUMAN
    Recommended name:
    Mono [ADP-ribose] polymerase PARP16
    Protein Accession:
    Q8N5Y8
    Secondary Accessions:
    • Q6PK64
    • Q9NX03

    Protein attributes for PARP16 Gene

    Size:
    322 amino acids
    Molecular mass:
    36383 Da
    Quaternary structure:
    • Interacts with KPNB1.

    Three dimensional structures from OCA and Proteopedia for PARP16 Gene

    Alternative splice isoforms for PARP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP16 Gene

Proteomics data for PARP16 Gene at MOPED

Post-translational modifications for PARP16 Gene

Other Protein References for PARP16 Gene

No data available for DME Specific Peptides for PARP16 Gene

Domains & Families for PARP16 Gene

Gene Families for PARP16 Gene

Protein Domains for PARP16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5Y8

UniProtKB/Swiss-Prot:

PAR16_HUMAN :
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
Domain:
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
  • Contains 1 PARP alpha-helical domain.
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP16: view

Function for PARP16 Gene

Molecular function for PARP16 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=290 uM for NAD (at 37 degrees Celsius) {ECO:0000269 PubMed:22701565}; Vmax=0.7 pmol/h/ug enzyme (at 37 degrees Celsius) {ECO:0000269 PubMed:22701565};
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

Enzyme Numbers (IUBMB) for PARP16 Gene

Gene Ontology (GO) - Molecular Function for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IMP 22701565
GO:0043539 protein serine/threonine kinase activator activity IMP 23103912
genes like me logo Genes that share ontologies with PARP16: view
genes like me logo Genes that share phenotypes with PARP16: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP16 Gene

Localization for PARP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP16 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP16 Gene COMPARTMENTS Subcellular localization image for PARP16 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with PARP16: view

Pathways & Interactions for PARP16 Gene

SuperPathways for PARP16 Gene

No Data Available

Interacting Proteins for PARP16 Gene

Gene Ontology (GO) - Biological Process for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IMP 22701565
GO:0008152 metabolic process IEA --
GO:0060548 negative regulation of cell death IMP 23103912
genes like me logo Genes that share ontologies with PARP16: view

No data available for Pathways by source and SIGNOR curated interactions for PARP16 Gene

Drugs & Compounds for PARP16 Gene

(3) Drugs for PARP16 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 353,361
NU1025 Experimental Pharma Potent PARP inhibitor 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for PARP16 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7
genes like me logo Genes that share compounds with PARP16: view

Transcripts for PARP16 Gene

Unigene Clusters for PARP16 Gene

Poly (ADP-ribose) polymerase family, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6:
SP7: - - - - - - -

Relevant External Links for PARP16 Gene

GeneLoc Exon Structure for
PARP16
ECgene alternative splicing isoforms for
PARP16

Expression for PARP16 Gene

mRNA expression in normal human tissues for PARP16 Gene

Protein differential expression in normal tissues from HIPED for PARP16 Gene

This gene is overexpressed in Fetal ovary (16.0), Fetal testis (12.0), Ovary (9.5), Blymphocyte (8.6), Prostate (6.9), and CD4 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP16 Gene



SOURCE GeneReport for Unigene cluster for PARP16 Gene Hs.30634

genes like me logo Genes that share expression patterns with PARP16: view

Protein tissue co-expression partners for PARP16 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PARP16 Gene

Orthologs for PARP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for PARP16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP16 36
  • 100 (a)
OneToOne
PARP16 35
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PARP16 36
  • 82 (a)
OneToOne
PARP16 35
  • 90.89 (n)
  • 92.55 (a)
dog
(Canis familiaris)
Mammalia PARP16 35
  • 90.37 (n)
  • 92.24 (a)
PARP16 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp16 16
Parp16 36
  • 81 (a)
OneToOne
Parp16 35
  • 87.27 (n)
  • 90.37 (a)
oppossum
(Monodelphis domestica)
Mammalia PARP16 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP16 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp16 35
  • 85.61 (n)
  • 89.13 (a)
chicken
(Gallus gallus)
Aves PARP16 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP16 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp16 35
  • 64.19 (n)
  • 65.37 (a)
zebrafish
(Danio rerio)
Actinopterygii parp16 36
  • 58 (a)
OneToOne
Dr.12643 35
parp16 35
  • 63.54 (n)
  • 63.12 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007419 35
  • 47.77 (n)
  • 37.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.87 36
  • 40 (a)
OneToOne
Species with no ortholog for PARP16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP16 Gene

ENSEMBL:
Gene Tree for PARP16 (if available)
TreeFam:
Gene Tree for PARP16 (if available)

Paralogs for PARP16 Gene

No data available for Paralogs for PARP16 Gene

Variants for PARP16 Gene

Sequence variations from dbSNP and Humsavar for PARP16 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs17852901 - 65,259,538(+) GCTCG(A/G)AGCCC nc-transcript-variant, reference, missense
rs894494 -- 65,264,104(-) CCCCA(A/G)TACAA intron-variant
rs504766 -- 65,270,437(-) GCAGA(A/G)CTCAA intron-variant
rs920688 -- 65,255,261(+) TCCTG(C/T)GCTAA intron-variant
rs1561890 -- 65,247,069(-) AGGCT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP16 Gene

Variant ID Type Subtype PubMed ID
nsv904309 CNV Loss 21882294
nsv457182 CNV Loss 19166990
dgv2398n71 CNV Loss 21882294

Variation tolerance for PARP16 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP16 Gene

HapMap Linkage Disequilibrium report
PARP16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP16 Gene

Disorders for PARP16 Gene

Relevant External Links for PARP16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP16

No disorders were found for PARP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP16 Gene

Publications for PARP16 Gene

  1. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP- ribosyltransferase that interacts with, and modifies karyopherin- beta1. (PMID: 22701565) Di Paola S. … Di Girolamo M. (PLoS ONE 2012) 3 4 67
  2. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-I^1 mono-ADP-ribosylation by ARTD15. (PMID: 25037261) Di Girolamo M. (Curr. Top. Microbiol. Immunol. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PARP16 Gene

Sources for PARP16 Gene

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