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Aliases for PARP16 Gene

Aliases for PARP16 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 16 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 15 3 4
  • Poly [ADP-Ribose] Polymerase 16 3 4
  • C15orf30 3 4
  • PARP-16 3 4
  • ARTD15 3 4
  • Chromosome 15 Open Reading Frame 30 2
  • Mono [ADP-Ribose] Polymerase PARP16 3
  • EC 2.4.2.30 4
  • PART15 3

External Ids for PARP16 Gene

Previous HGNC Symbols for PARP16 Gene

  • C15orf30

Previous GeneCards Identifiers for PARP16 Gene

  • GC15M063337
  • GC15M065550
  • GC15M042375

Summaries for PARP16 Gene

GeneCards Summary for PARP16 Gene

PARP16 (Poly(ADP-Ribose) Polymerase Family Member 16) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include kinase binding and protein serine/threonine kinase activator activity.

UniProtKB/Swiss-Prot for PARP16 Gene

  • Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

Tocris Summary for PARP16 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP16 Gene

Genomics for PARP16 Gene

Regulatory Elements for PARP16 Gene

Enhancers for PARP16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F065257 0.9 ENCODE 24.6 +41.9 41869 3.5 PKNOX1 FEZF1 CHAMP1 GATA2 SCRT2 ZNF362 CEBPB ZEB2 KLF16 SMARCA4 PARP16 IGDCC3 RNU6-686P CILP ENSG00000206903 RNU5A-1 CLPX RNU5B-1 MIR1272
GH15F065303 1.6 FANTOM5 ENCODE 13.3 -3.9 -3854 2.2 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 CILP ZNF609 TRIP4 IGDCC3 PARP16 CLPX MTFMT HACD3 RBPMS2 SPG21
GH15F065295 1.5 FANTOM5 ENCODE 13.8 +3.3 3252 4.1 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF609 MTFMT TRIP4 ENSG00000264937 PARP16 ENSG00000259635 SLC24A1 HACD3 SPG21 CILP
GH15F065274 1.1 Ensembl ENCODE 16.4 +24.9 24927 1.4 HDAC1 THRB ZNF366 SCRT2 FOS NCOA1 ZEB2 SMARCA4 IKZF1 SP7 PARP16 RNU5B-1 RNU6-686P CILP CLPX IGDCC3 ENSG00000206903
GH15F065285 1.1 ENCODE 15.6 +13.9 13850 2.8 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 FOS PARP16 SLC24A1 ENSG00000206903 GC15P066982
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP16 on UCSC Golden Path with GeneCards custom track

Promoters for PARP16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000650825 418 801 ELF3 TBP ARID4B ZSCAN9 SLC30A9 GATA4 CREM MIXL1 THAP11 SMAD5

Genomic Location for PARP16 Gene

Chromosome:
15
Start:
65,234,460 bp from pter
End:
65,300,618 bp from pter
Size:
66,159 bases
Orientation:
Minus strand

Genomic View for PARP16 Gene

Genes around PARP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP16 Gene

Proteins for PARP16 Gene

  • Protein details for PARP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Y8-PAR16_HUMAN
    Recommended name:
    Mono [ADP-ribose] polymerase PARP16
    Protein Accession:
    Q8N5Y8
    Secondary Accessions:
    • Q6PK64
    • Q9NX03

    Protein attributes for PARP16 Gene

    Size:
    322 amino acids
    Molecular mass:
    36383 Da
    Quaternary structure:
    • Interacts with KPNB1.

    Three dimensional structures from OCA and Proteopedia for PARP16 Gene

    Alternative splice isoforms for PARP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP16 Gene

Post-translational modifications for PARP16 Gene

No data available for DME Specific Peptides for PARP16 Gene

Domains & Families for PARP16 Gene

Gene Families for PARP16 Gene

Protein Domains for PARP16 Gene

Suggested Antigen Peptide Sequences for PARP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5Y8

UniProtKB/Swiss-Prot:

PAR16_HUMAN :
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
Domain:
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
  • Contains 1 PARP alpha-helical domain.
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP16: view

Function for PARP16 Gene

Molecular function for PARP16 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=290 uM for NAD (at 37 degrees Celsius) {ECO:0000269 PubMed:22701565}; Vmax=0.7 pmol/h/ug enzyme (at 37 degrees Celsius) {ECO:0000269 PubMed:22701565};
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

Enzyme Numbers (IUBMB) for PARP16 Gene

Gene Ontology (GO) - Molecular Function for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IMP 22701565
GO:0005515 protein binding IPI 22701565
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0019900 kinase binding IPI 23103912
genes like me logo Genes that share ontologies with PARP16: view
genes like me logo Genes that share phenotypes with PARP16: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP16 Gene

Localization for PARP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP16 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP16 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 22701565
GO:0005783 endoplasmic reticulum IMP 23103912
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PARP16: view

Pathways & Interactions for PARP16 Gene

genes like me logo Genes that share pathways with PARP16: view

Pathways by source for PARP16 Gene

Interacting Proteins for PARP16 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261888%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000282570%0d%0a9606.ENSP00000249396%0d%0a9606.ENSP00000430432%0d%0a
Selected Interacting proteins: ENSP00000261888 Q8N5Y8-PAR16_HUMAN for PARP16 Gene via STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IMP 22701565
GO:0006986 response to unfolded protein IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response IMP 23103912
GO:0030968 endoplasmic reticulum unfolded protein response IMP 23103912
GO:0060548 negative regulation of cell death IMP 23103912
genes like me logo Genes that share ontologies with PARP16: view

No data available for SIGNOR curated interactions for PARP16 Gene

Drugs & Compounds for PARP16 Gene

(6) Drugs for PARP16 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 902,906
NAD Pharma Full agonist, Agonist 0
BYK 204165 Pharma PARP-1 inhibitor,potent and selective, Selective PARP-1 inhibitor 0
EB 47 Pharma Potent PARP-1 inhibitor 0
JW 55 Pharma PARP domain inhibitor, Tankyrase inhibitor 0

(1) Additional Compounds for PARP16 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP16 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3
genes like me logo Genes that share compounds with PARP16: view

Transcripts for PARP16 Gene

Unigene Clusters for PARP16 Gene

Poly (ADP-ribose) polymerase family, member 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6:
SP7: - - - - - - -

Relevant External Links for PARP16 Gene

GeneLoc Exon Structure for
PARP16
ECgene alternative splicing isoforms for
PARP16

Expression for PARP16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP16 Gene

Protein differential expression in normal tissues from HIPED for PARP16 Gene

This gene is overexpressed in Fetal ovary (16.0), Fetal testis (12.0), Ovary (9.5), Blymphocyte (8.6), Prostate (6.9), and CD4 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP16 Gene



Protein tissue co-expression partners for PARP16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP16 Gene:

PARP16

SOURCE GeneReport for Unigene cluster for PARP16 Gene:

Hs.30634
genes like me logo Genes that share expression patterns with PARP16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PARP16 Gene

Orthologs for PARP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for PARP16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP16 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia PARP16 34 35
  • 90.89 (n)
dog
(Canis familiaris)
Mammalia PARP16 34 35
  • 90.37 (n)
mouse
(Mus musculus)
Mammalia Parp16 34 16 35
  • 87.27 (n)
rat
(Rattus norvegicus)
Mammalia Parp16 34
  • 85.61 (n)
oppossum
(Monodelphis domestica)
Mammalia PARP16 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP16 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP16 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP16 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp16 34
  • 64.19 (n)
zebrafish
(Danio rerio)
Actinopterygii parp16 34 35
  • 63.54 (n)
Dr.12643 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007419 34
  • 47.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.87 35
  • 40 (a)
OneToOne
Species where no ortholog for PARP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP16 Gene

ENSEMBL:
Gene Tree for PARP16 (if available)
TreeFam:
Gene Tree for PARP16 (if available)

Paralogs for PARP16 Gene

No data available for Paralogs for PARP16 Gene

Variants for PARP16 Gene

Sequence variations from dbSNP and Humsavar for PARP16 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083571 -- 65,276,572(+) TGTTG(C/T)CCAGG intron-variant
rs10083573 -- 65,276,745(+) ggagg(C/T)tgagg intron-variant
rs10467935 -- 65,268,739(+) GCCCC(C/T)TAGTC intron-variant
rs10467936 -- 65,268,817(+) tggca(C/T)gatct intron-variant
rs1057254 -- 65,286,695(-) AGTTC(C/T)TTTAT nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PARP16 Gene

Variant ID Type Subtype PubMed ID
nsv457182 CNV loss 19166990
nsv476908 CNV novel sequence insertion 20440878
nsv569705 CNV loss 21841781

Variation tolerance for PARP16 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP16 Gene

Disorders for PARP16 Gene

Relevant External Links for PARP16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP16

No disorders were found for PARP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP16 Gene

Publications for PARP16 Gene

  1. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP- ribosyltransferase that interacts with, and modifies karyopherin- beta1. (PMID: 22701565) Di Paola S. … Di Girolamo M. (PLoS ONE 2012) 3 4 64
  2. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK-and IRE1alpha-mediated unfolded protein response. (PMID: 23103912) Jwa M. … Chang P. (Nat. Cell Biol. 2012) 3 4 64
  3. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PARP16 Gene

Sources for PARP16 Gene

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