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Aliases for PARP15 Gene

Aliases for PARP15 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 15 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 7 3 4
  • B-Aggressive Lymphoma Protein 3 3 4
  • EC 4 61
  • PARP-15 3 4
  • ARTD7 3 4
  • BAL3 3 4
  • Poly [ADP-Ribose] Polymerase 15 3
  • B-Aggressive Lymphoma 3 3
  • PART7 3

External Ids for PARP15 Gene

Previous GeneCards Identifiers for PARP15 Gene

  • GC03P123817
  • GC03P122296
  • GC03P119669

Summaries for PARP15 Gene

Entrez Gene Summary for PARP15 Gene

  • PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]

GeneCards Summary for PARP15 Gene

PARP15 (Poly(ADP-Ribose) Polymerase Family Member 15) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP15 Gene

  • Transcriptional repressor. Has ADP-ribosyltransferase activity.

Tocris Summary for PARP15 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP15 Gene

Genomics for PARP15 Gene

Regulatory Elements for PARP15 Gene

Enhancers for PARP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F122572 0.9 Ensembl ENCODE 10.6 -4.1 -4058 1.3 PKNOX1 MLX WRNIP1 ARID4B YY1 GLIS2 ZNF143 FOS SP5 TSHZ1 PARP14 PARP15 ENSG00000273454 PARP9
GH03F122609 1 Ensembl ENCODE 8.6 +32.8 32830 1.2 PKNOX1 TBL1XR1 BMI1 ZBTB40 RARA CBX5 SCRT2 ZNF143 ETV6 FOS PARP15 PIR41127 LOC100421636
GH03F122589 0.6 ENCODE 0.4 +11.9 11935 0.2 BMI1 EBF1 ZNF316 EED NFE2 CREM MAFK NFE2L2 MTA2 TRIM22 PARP14 LOC100421636 PARP15
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PARP15 on UCSC Golden Path with GeneCards custom track

Promoters for PARP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PARP15 Gene

122,577,454 bp from pter
122,639,047 bp from pter
61,594 bases
Plus strand

Genomic View for PARP15 Gene

Genes around PARP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP15 Gene

Proteins for PARP15 Gene

  • Protein details for PARP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly [ADP-ribose] polymerase 15
    Protein Accession:
    Secondary Accessions:
    • J3KR47
    • Q8N1K3

    Protein attributes for PARP15 Gene

    678 amino acids
    Molecular mass:
    74576 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAY64451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP15 Gene

    Alternative splice isoforms for PARP15 Gene


neXtProt entry for PARP15 Gene

Selected DME Specific Peptides for PARP15 Gene


Post-translational modifications for PARP15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP15 Gene

Gene Families for PARP15 Gene

Protein Domains for PARP15 Gene

Suggested Antigen Peptide Sequences for PARP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Macro domains.
  • Contains 2 Macro domains.
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP15: view

Function for PARP15 Gene

Molecular function for PARP15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Has ADP-ribosyltransferase activity.

Enzyme Numbers (IUBMB) for PARP15 Gene

Gene Ontology (GO) - Molecular Function for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP15: view

Phenotypes for PARP15 Gene

genes like me logo Genes that share phenotypes with PARP15: view

Animal Model Products

miRNA for PARP15 Gene

miRTarBase miRNAs that target PARP15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP15 Gene

Localization for PARP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP15 Gene

Subcellular locations from

Jensen Localization Image for PARP15 Gene COMPARTMENTS Subcellular localization image for PARP15 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PARP15: view

Pathways & Interactions for PARP15 Gene

SuperPathways for PARP15 Gene

No Data Available

Interacting Proteins for PARP15 Gene

Selected Interacting proteins: Q460N3-PAR15_HUMAN for PARP15 Gene via IID

Gene Ontology (GO) - Biological Process for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PARP15: view

No data available for Pathways by source and SIGNOR curated interactions for PARP15 Gene

Drugs & Compounds for PARP15 Gene

(7) Drugs for PARP15 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 902,906
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Experimental Pharma Target 0
NAD Pharma Full agonist, Agonist 0
BYK 204165 Pharma PARP-1 inhibitor,potent and selective, Selective PARP-1 inhibitor 0
EB 47 Pharma Potent PARP-1 inhibitor 0

(1) Additional Compounds for PARP15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride

(5) Tocris Compounds for PARP15 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3
genes like me logo Genes that share compounds with PARP15: view

Transcripts for PARP15 Gene

Unigene Clusters for PARP15 Gene

Poly (ADP-ribose) polymerase family, member 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP15 Gene

No ASD Table

Relevant External Links for PARP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP15 Gene

This gene is overexpressed in Spleen (x11.6), Small Intestine - Terminal Ileum (x6.9), and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for PARP15 Gene

This gene is overexpressed in Adipocyte (54.1) and Blymphocyte (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARP15 Gene

Protein tissue co-expression partners for PARP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP15 Gene:


SOURCE GeneReport for Unigene cluster for PARP15 Gene:

genes like me logo Genes that share expression patterns with PARP15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PARP15 Gene

Orthologs for PARP15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PARP15 34 35
  • 99.21 (n)
(Canis familiaris)
Mammalia PARP15 34 35
  • 78.18 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 18 (a)
-- 35
  • 16 (a)
(Gallus gallus)
Aves -- 35
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
-- 35
  • 16 (a)
(Danio rerio)
Actinopterygii CABZ01031892.1 35
  • 15 (a)
si:ch211-219a4.3 35
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
Species where no ortholog for PARP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP15 Gene

Gene Tree for PARP15 (if available)
Gene Tree for PARP15 (if available)

Paralogs for PARP15 Gene

Paralogs for PARP15 Gene

(2) SIMAP similar genes for PARP15 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARP15: view

Variants for PARP15 Gene

Sequence variations from dbSNP and Humsavar for PARP15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1045089 -- 122,574,362(+) TTAAA(C/T)GGTTC upstream-variant-2KB, utr-variant-3-prime
rs10511411 -- 122,630,292(-) CTCCA(A/G)CTTCT intron-variant
rs10511412 -- 122,630,268(-) GACTT(C/T)GGCTA intron-variant
rs10511413 -- 122,630,140(-) CATGA(C/T)AACTA intron-variant
rs10602517 -- 122,584,629(+) AGTAC(-/AATG)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP15 Gene

Variant ID Type Subtype PubMed ID
esv2512026 CNV deletion 19546169
nsv829705 CNV loss 17160897
nsv967054 CNV duplication 23825009

Variation tolerance for PARP15 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.03; 92.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP15 Gene

Disorders for PARP15 Gene

Relevant External Links for PARP15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PARP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP15 Gene

Publications for PARP15 Gene

  1. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3 46 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PMID: 16061477) Aguiar R.C.T. … Shipp M.A. (J. Biol. Chem. 2005) 3 4 64
  4. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PARP15 Gene

Sources for PARP15 Gene

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