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Aliases for PARP15 Gene

Aliases for PARP15 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 15 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 7 3 4
  • B-Aggressive Lymphoma Protein 3 3 4
  • EC 4 56
  • PARP-15 3 4
  • ARTD7 3 4
  • BAL3 3 4
  • Poly [ADP-Ribose] Polymerase 15 3
  • B-Aggressive Lymphoma 3 3
  • PART7 3

External Ids for PARP15 Gene

Previous GeneCards Identifiers for PARP15 Gene

  • GC03P123817
  • GC03P122296
  • GC03P119669

Summaries for PARP15 Gene

Entrez Gene Summary for PARP15 Gene

  • PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]

GeneCards Summary for PARP15 Gene

PARP15 (Poly(ADP-Ribose) Polymerase Family Member 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP15 Gene

  • Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477).

Tocris Summary for PARP15 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Additional gene information for PARP15 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP15 Gene

Genomics for PARP15 Gene

GeneHancer (GH) Regulatory Elements for PARP15 Gene

Promoters and enhancers for PARP15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I122575 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570.1 0.0 -8 4.4 HDGF PKNOX1 SMAD1 RB1 BMI1 BATF KLF5 IRF4 ZNF143 ATF7 PARP15 GOLGB1 SEC22A LOC102723582 PARP14 DIRC2 PARP9 DTX3L HSPBAP1 CD86
GH03I122572 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.7 -4.1 -4058 1.3 PKNOX1 FOXA2 MLX ARID4B IRF4 YY1 GLIS2 ZNF143 ATF7 FOS PARP14 ENSG00000273454 PARP15 DTX3L PARP9
GH03I122609 Enhancer 1 Ensembl ENCODE 8.6 +32.8 32829 1.2 PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 SCRT2 ZNF143 ATF7 ETV6 PARP15 PIR41127 LOC100421636
GH03I122589 Enhancer 1 ENCODE dbSUPER 0.4 +11.9 11935 0.2 BACH1 EBF1 BMI1 BATF IRF4 ZNF316 NFATC1 ATF7 NFE2 MAFK PARP14 LOC100421636 PARP15
GH03I122616 Enhancer 0.7 ENCODE 0.3 +39.7 39653 0.7 PKNOX1 SMAD1 RB1 EBF1 BMI1 BATF KLF5 ZNF207 ZNF143 ATF7 PIR41127 PARP15 EIF4BP8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PARP15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PARP15 gene promoter:

Genomic Locations for PARP15 Gene

Genomic Locations for PARP15 Gene
61,594 bases
Plus strand

Genomic View for PARP15 Gene

Genes around PARP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP15 Gene

Proteins for PARP15 Gene

  • Protein details for PARP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly [ADP-ribose] polymerase 15
    Protein Accession:
    Secondary Accessions:
    • J3KR47
    • Q8N1K3

    Protein attributes for PARP15 Gene

    678 amino acids
    Molecular mass:
    74576 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAY64451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP15 Gene

    Alternative splice isoforms for PARP15 Gene


neXtProt entry for PARP15 Gene

Selected DME Specific Peptides for PARP15 Gene


Post-translational modifications for PARP15 Gene

No Post-translational modifications

Domains & Families for PARP15 Gene

Gene Families for PARP15 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PARP15 Gene

Suggested Antigen Peptide Sequences for PARP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP15: view

No data available for UniProtKB/Swiss-Prot for PARP15 Gene

Function for PARP15 Gene

Molecular function for PARP15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477).

Enzyme Numbers (IUBMB) for PARP15 Gene

Phenotypes From GWAS Catalog for PARP15 Gene

Gene Ontology (GO) - Molecular Function for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IMP 16061477
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IMP 16061477
GO:0005515 protein binding IPI 23473667
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP15: view

Phenotypes for PARP15 Gene

genes like me logo Genes that share phenotypes with PARP15: view

Animal Model Products

CRISPR Products

miRNA for PARP15 Gene

miRTarBase miRNAs that target PARP15

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP15 Gene

Localization for PARP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP15 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP15 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC 16061477
genes like me logo Genes that share ontologies with PARP15: view

Pathways & Interactions for PARP15 Gene

SuperPathways for PARP15 Gene

No Data Available

Interacting Proteins for PARP15 Gene

Gene Ontology (GO) - Biological Process for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 16061477
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0070212 protein poly-ADP-ribosylation IMP 16061477
genes like me logo Genes that share ontologies with PARP15: view

No data available for Pathways by source and SIGNOR curated interactions for PARP15 Gene

Drugs & Compounds for PARP15 Gene

(7) Drugs for PARP15 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Nutra 942,946
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Experimental Pharma Target 0
NAD Pharma Full agonist, Agonist 0

(1) Additional Compounds for PARP15 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for PARP15 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP15: view

Transcripts for PARP15 Gene

Unigene Clusters for PARP15 Gene

Poly (ADP-ribose) polymerase family, member 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP15 Gene

No ASD Table

Relevant External Links for PARP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP15 Gene

This gene is overexpressed in Spleen (x11.6), Small Intestine - Terminal Ileum (x6.9), and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for PARP15 Gene

This gene is overexpressed in Adipocyte (54.1) and Blymphocyte (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARP15 Gene

Protein tissue co-expression partners for PARP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP15 Gene:


SOURCE GeneReport for Unigene cluster for PARP15 Gene:


Evidence on tissue expression from TISSUES for PARP15 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with PARP15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP15 Gene

Orthologs for PARP15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PARP15 33 34
  • 99.21 (n)
(Canis familiaris)
Mammalia PARP15 33 34
  • 78.18 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 18 (a)
-- 34
  • 16 (a)
(Gallus gallus)
Aves -- 34
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
-- 34
  • 16 (a)
(Danio rerio)
Actinopterygii CABZ01031892.1 34
  • 15 (a)
si:ch211-219a4.3 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for PARP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP15 Gene

Gene Tree for PARP15 (if available)
Gene Tree for PARP15 (if available)

Paralogs for PARP15 Gene

Paralogs for PARP15 Gene

(2) SIMAP similar genes for PARP15 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARP15: view

Variants for PARP15 Gene

Sequence variations from dbSNP and Humsavar for PARP15 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000004831 -- 122,622,714(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000028196 -- 122,609,045(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000044232 -- 122,627,809(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000049615 -- 122,634,780(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000101516 -- 122,635,107(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for PARP15 Gene

Variant ID Type Subtype PubMed ID
esv2512026 CNV deletion 19546169
nsv829705 CNV loss 17160897
nsv967054 CNV duplication 23825009

Variation tolerance for PARP15 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.03; 92.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP15 Gene

Disorders for PARP15 Gene

Additional Disease Information for PARP15

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PARP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP15 Gene

Publications for PARP15 Gene

  1. Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein. (PMID: 25635049) Karlberg T … Schüler H (The Journal of biological chemistry 2015) 3 4 58
  2. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. (PMID: 23473667) Forst AH … Lüscher B (Structure (London, England : 1993) 2013) 3 4 58
  3. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium … Sullivan PF (Molecular psychiatry 2013) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PMID: 16061477) Aguiar RC … Shipp MA (The Journal of biological chemistry 2005) 3 4 58

Products for PARP15 Gene

Sources for PARP15 Gene

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