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Aliases for PARP15 Gene

Aliases for PARP15 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 15 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 7 3 4
  • B-Aggressive Lymphoma Protein 3 3 4
  • EC 2.4.2.30 4 61
  • PARP-15 3 4
  • ARTD7 3 4
  • BAL3 3 4
  • Poly [ADP-Ribose] Polymerase 15 3
  • B-Aggressive Lymphoma 3 3
  • PART7 3

External Ids for PARP15 Gene

Previous GeneCards Identifiers for PARP15 Gene

  • GC03P123817
  • GC03P122296
  • GC03P119669

Summaries for PARP15 Gene

Entrez Gene Summary for PARP15 Gene

  • PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]

GeneCards Summary for PARP15 Gene

PARP15 (Poly(ADP-Ribose) Polymerase Family Member 15) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP15 Gene

  • Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477).

Tocris Summary for PARP15 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP15 Gene

Genomics for PARP15 Gene

Regulatory Elements for PARP15 Gene

Enhancers for PARP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G122575 1.4 FANTOM5 ENCODE dbSUPER 20 0.0 -9 4.4 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 ZBTB40 EGR1 ZNF143 RELB PARP15 LOC102723582 PARP14 DIRC2 PARP9 DTX3L HSPBAP1 CD86
GH03G122572 1.5 Ensembl ENCODE dbSUPER 10.6 -4.1 -4058 1.3 PKNOX1 MLX WRNIP1 ARID4B YY1 GLIS2 ZNF143 FOS SP5 TSHZ1 PARP14 PARP15 ENSG00000273454 PARP9
GH03G122609 1.1 Ensembl ENCODE 8.6 +32.8 32830 1.2 PKNOX1 TBL1XR1 BMI1 ZBTB40 RARA CBX5 SCRT2 ZNF143 RELB ETV6 PARP15 PIR41127 LOC100421636
GH03G122589 1.1 ENCODE dbSUPER 0.4 +11.9 11935 0.2 BACH1 BMI1 EBF1 ZNF316 ARID3A EED NFE2 RELB IKZF2 CREM PARP14 LOC100421636 PARP15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP15 on UCSC Golden Path with GeneCards custom track

Promoters for PARP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157342 546 801 BCOR HDGF TBP CTCF BACH1 POLR2A EED IKZF2 EZH2 L3MBTL2

Genomic Location for PARP15 Gene

Chromosome:
3
Start:
122,577,454 bp from pter
End:
122,639,047 bp from pter
Size:
61,594 bases
Orientation:
Plus strand

Genomic View for PARP15 Gene

Genes around PARP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP15 Gene

Proteins for PARP15 Gene

  • Protein details for PARP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q460N3-PAR15_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 15
    Protein Accession:
    Q460N3
    Secondary Accessions:
    • J3KR47
    • Q8N1K3

    Protein attributes for PARP15 Gene

    Size:
    678 amino acids
    Molecular mass:
    74576 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAY64451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP15 Gene

    Alternative splice isoforms for PARP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP15 Gene

Selected DME Specific Peptides for PARP15 Gene

Q460N3:
  • GKGTYFA
  • KIERIQN
  • PAIGTGN

Post-translational modifications for PARP15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PARP15 Gene

Gene Families for PARP15 Gene

Protein Domains for PARP15 Gene

Suggested Antigen Peptide Sequences for PARP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP15: view

No data available for UniProtKB/Swiss-Prot for PARP15 Gene

Function for PARP15 Gene

Molecular function for PARP15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477).

Enzyme Numbers (IUBMB) for PARP15 Gene

Gene Ontology (GO) - Molecular Function for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IMP 16061477
GO:0003950 NAD+ ADP-ribosyltransferase activity IMP 16061477
GO:0005515 protein binding IPI 23473667
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP15: view

Phenotypes for PARP15 Gene

genes like me logo Genes that share phenotypes with PARP15: view

Animal Model Products

CRISPR Products

miRNA for PARP15 Gene

miRTarBase miRNAs that target PARP15

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP15 Gene

Localization for PARP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP15 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC 16061477
genes like me logo Genes that share ontologies with PARP15: view

Pathways & Interactions for PARP15 Gene

SuperPathways for PARP15 Gene

No Data Available

Interacting Proteins for PARP15 Gene

Gene Ontology (GO) - Biological Process for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 16061477
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0070212 protein poly-ADP-ribosylation IMP 16061477
genes like me logo Genes that share ontologies with PARP15: view

No data available for Pathways by source and SIGNOR curated interactions for PARP15 Gene

Drugs & Compounds for PARP15 Gene

(7) Drugs for PARP15 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 919,923
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Experimental Pharma Target 0
NAD Pharma Full agonist, Agonist 0
BYK 204165 Pharma PARP-1 inhibitor,potent and selective, Selective PARP-1 inhibitor 0
EB 47 Pharma Potent PARP-1 inhibitor 0

(1) Additional Compounds for PARP15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP15 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3
genes like me logo Genes that share compounds with PARP15: view

Transcripts for PARP15 Gene

Unigene Clusters for PARP15 Gene

Poly (ADP-ribose) polymerase family, member 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP15 Gene

No ASD Table

Relevant External Links for PARP15 Gene

GeneLoc Exon Structure for
PARP15
ECgene alternative splicing isoforms for
PARP15

Expression for PARP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP15 Gene

This gene is overexpressed in Spleen (x11.6), Small Intestine - Terminal Ileum (x6.9), and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for PARP15 Gene

This gene is overexpressed in Adipocyte (54.1) and Blymphocyte (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARP15 Gene



Protein tissue co-expression partners for PARP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP15 Gene:

PARP15

SOURCE GeneReport for Unigene cluster for PARP15 Gene:

Hs.120250

Evidence on tissue expression from TISSUES for PARP15 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with PARP15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP15 Gene

Orthologs for PARP15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP15 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia PARP15 34 35
  • 78.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 18 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01031892.1 35
  • 15 (a)
ManyToMany
si:ch211-219a4.3 35
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for PARP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP15 Gene

ENSEMBL:
Gene Tree for PARP15 (if available)
TreeFam:
Gene Tree for PARP15 (if available)

Paralogs for PARP15 Gene

Paralogs for PARP15 Gene

(2) SIMAP similar genes for PARP15 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARP15: view

Variants for PARP15 Gene

Sequence variations from dbSNP and Humsavar for PARP15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000004831 -- 122,622,714(+) AACGC(G/T)TTCCT intron-variant
rs1000028196 -- 122,609,045(+) CACTA(C/T)ACCCA intron-variant, upstream-variant-2KB
rs1000044232 -- 122,627,809(+) GCATT(C/G)TCCTT intron-variant
rs1000049615 -- 122,634,780(+) ATATA(C/G)CAACA intron-variant
rs1000101516 -- 122,635,107(+) ATAAT(A/G)AGAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PARP15 Gene

Variant ID Type Subtype PubMed ID
esv2512026 CNV deletion 19546169
nsv829705 CNV loss 17160897
nsv967054 CNV duplication 23825009

Variation tolerance for PARP15 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.03; 92.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP15 Gene

Disorders for PARP15 Gene

Relevant External Links for PARP15

Genetic Association Database (GAD)
PARP15
Human Genome Epidemiology (HuGE) Navigator
PARP15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP15

No disorders were found for PARP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP15 Gene

Publications for PARP15 Gene

  1. Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein. (PMID: 25635049) Karlberg T. … SchA1ler H. (J. Biol. Chem. 2015) 3 4 64
  2. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3 46 64
  3. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. (PMID: 23473667) Forst A.H. … Luscher B. (Structure 2013) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PMID: 16061477) Aguiar R.C.T. … Shipp M.A. (J. Biol. Chem. 2005) 3 4 64

Products for PARP15 Gene

Sources for PARP15 Gene

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