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Aliases for PARP15 Gene

Aliases for PARP15 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 15 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 7 3 4
  • B-Aggressive Lymphoma Protein 3 3 4
  • EC 2.4.2.30 4 63
  • PARP-15 3 4
  • ARTD7 3 4
  • BAL3 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 15 3
  • B-Aggressive Lymphoma 3 3
  • PART7 3

External Ids for PARP15 Gene

Previous GeneCards Identifiers for PARP15 Gene

  • GC03P123817
  • GC03P122296
  • GC03P119669

Summaries for PARP15 Gene

Entrez Gene Summary for PARP15 Gene

  • PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]

GeneCards Summary for PARP15 Gene

PARP15 (Poly(ADP-Ribose) Polymerase Family Member 15) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP15 Gene

  • Transcriptional repressor. Has ADP-ribosyltransferase activity.

Tocris Summary for PARP15 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP15 Gene

Genomics for PARP15 Gene

Regulatory Elements for PARP15 Gene

Promoters for PARP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARP15 on UCSC Golden Path with GeneCards custom track

Genomic Location for PARP15 Gene

Chromosome:
3
Start:
122,577,454 bp from pter
End:
122,639,047 bp from pter
Size:
61,594 bases
Orientation:
Plus strand

Genomic View for PARP15 Gene

Genes around PARP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP15 Gene

Proteins for PARP15 Gene

  • Protein details for PARP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q460N3-PAR15_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 15
    Protein Accession:
    Q460N3
    Secondary Accessions:
    • J3KR47
    • Q8N1K3

    Protein attributes for PARP15 Gene

    Size:
    678 amino acids
    Molecular mass:
    74576 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAY64451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP15 Gene

    Alternative splice isoforms for PARP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP15 Gene

Proteomics data for PARP15 Gene at MOPED

Selected DME Specific Peptides for PARP15 Gene

Post-translational modifications for PARP15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARP15 Gene

Domains & Families for PARP15 Gene

Gene Families for PARP15 Gene

Protein Domains for PARP15 Gene

Suggested Antigen Peptide Sequences for PARP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q460N3

UniProtKB/Swiss-Prot:

PAR15_HUMAN :
  • Contains 2 Macro domains.
Domain:
  • Contains 2 Macro domains.
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP15: view

Function for PARP15 Gene

Molecular function for PARP15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Has ADP-ribosyltransferase activity.

Enzyme Numbers (IUBMB) for PARP15 Gene

Phenotypes for PARP15 Gene

genes like me logo Genes that share phenotypes with PARP15: view

Animal Model Products

CRISPR Products

miRNA for PARP15 Gene

miRTarBase miRNAs that target PARP15

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP15 Gene

Localization for PARP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP15 Gene COMPARTMENTS Subcellular localization image for PARP15 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PARP15 Gene

Pathways & Interactions for PARP15 Gene

SuperPathways for PARP15 Gene

No Data Available

Interacting Proteins for PARP15 Gene

Gene Ontology (GO) - Biological Process for PARP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PARP15: view

No data available for Pathways by source and SIGNOR curated interactions for PARP15 Gene

Drugs & Compounds for PARP15 Gene

(4) Drugs for PARP15 Gene - From: HMDB, Tocris, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Experimental Pharma Target 0
Nicotinamide Experimental Nutra 353,361
NU1025 Experimental Pharma Potent PARP inhibitor 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for PARP15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP15 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
DR 2313 PARP-1 and PARP-2 inhibitor 284028-90-6
NU 1025 Potent PARP inhibitor 90417-38-2
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
genes like me logo Genes that share compounds with PARP15: view

Transcripts for PARP15 Gene

Unigene Clusters for PARP15 Gene

Poly (ADP-ribose) polymerase family, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP15 Gene

No ASD Table

Relevant External Links for PARP15 Gene

GeneLoc Exon Structure for
PARP15
ECgene alternative splicing isoforms for
PARP15

Expression for PARP15 Gene

mRNA expression in normal human tissues for PARP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP15 Gene

This gene is overexpressed in Spleen (x11.6), Small Intestine - Terminal Ileum (x6.9), and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for PARP15 Gene

This gene is overexpressed in Adipocyte (54.1) and Blymphocyte (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARP15 Gene



SOURCE GeneReport for Unigene cluster for PARP15 Gene Hs.120250

genes like me logo Genes that share expression patterns with PARP15: view

Protein tissue co-expression partners for PARP15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PARP15 Gene

Orthologs for PARP15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP15 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PARP15 35
  • 78.18 (n)
  • 69.08 (a)
PARP15 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARP15 35
  • 99.21 (n)
  • 98.97 (a)
PARP15 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 16 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01031892.1 36
  • 15 (a)
ManyToMany
si:ch211-219a4.3 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for PARP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP15 Gene

ENSEMBL:
Gene Tree for PARP15 (if available)
TreeFam:
Gene Tree for PARP15 (if available)

Paralogs for PARP15 Gene

Paralogs for PARP15 Gene

(2) SIMAP similar genes for PARP15 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARP15: view

Variants for PARP15 Gene

Sequence variations from dbSNP and Humsavar for PARP15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6793271 - 122,619,790(+) GTCAA(A/G)AGCTA reference, missense
rs12489170 - 122,635,945(+) CAAAG(A/G)GACGT reference, missense
rs34383355 - 122,632,208(-) TATTG(C/T)GTAGG reference, missense
rs963582 -- 122,577,969(-) CCCTA(A/G)AAGAG intron-variant
rs1143339 -- 122,638,785(-) TTCTG(C/T)ACAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PARP15 Gene

Variant ID Type Subtype PubMed ID
nsv877391 CNV Gain 21882294
nsv829705 CNV Loss 17160897
esv2512026 CNV Deletion 19546169

Variation tolerance for PARP15 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.03; 92.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP15 Gene

HapMap Linkage Disequilibrium report
PARP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP15 Gene

Disorders for PARP15 Gene

Relevant External Links for PARP15

Genetic Association Database (GAD)
PARP15
Human Genome Epidemiology (HuGE) Navigator
PARP15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP15

No disorders were found for PARP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP15 Gene

Publications for PARP15 Gene

  1. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3 48 67
  2. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3
  3. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for PARP15 Gene

Sources for PARP15 Gene

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