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PARP14 Gene

protein-coding   GIFtS: 56
GCID: GC03P122399

Poly (ADP-Ribose) Polymerase Family, Member 14

  Search for PARP14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly (ADP-Ribose) Polymerase Family, Member 141 2     EC 2.4.2.303 8
B Aggressive Lymphoma Protein 22 3     KIAA12683 5
ARTD82 3     B-Aggressive Lymphoma 22
BAL22 3     Collaborator Of STAT62
PARP-142 3     pART82
ADP-Ribosyltransferase Diphtheria Toxin-Like 82 3     Poly [ADP-Ribose] Polymerase 142

External Ids:    HGNC: 292321   Entrez Gene: 546252   Ensembl: ENSG000001731937   OMIM: 6100285   UniProtKB: Q460N53   

Export aliases for PARP14 gene to outside databases

Previous GC identifers: GC03P123897 GC03P119772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PARP14 Gene:
Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other
nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the
superfamily of enzymes that perform this modification (Ame et al., 2004 (PubMed 15273990)).(supplied by OMIM, Mar
2008)

GeneCards Summary for PARP14 Gene:
PARP14 (poly (ADP-ribose) polymerase family, member 14) is a protein-coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP15.

UniProtKB/Swiss-Prot: PAR14_HUMAN, Q460N5
Function: Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity

summary for PARP14 Gene:
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the
addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to
glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain
polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,
stroke and cardiovascular disease.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARP14 gene promoter:
         CUTL1   IRF-1   LCR-F1   GATA-1   Meis-1b   c-Ets-1   GATA-2   c-Myb   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARP14 promoter sequence
   Search Chromatin IP Primers for PARP14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21

PARP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARP14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P122399:  view genomic region     (about GC identifiers)

Start:
122,399,465 bp from pter      End:
122,449,687 bp from pter
Size:
50,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAR14_HUMAN, Q460N5 (See protein sequence)
Recommended Name: Poly [ADP-ribose] polymerase 14  
Size: 1801 amino acids; 202800 Da
Subunit: Interacts with STAT6 (By similarity)
Sequence caution: Sequence=AAY64449.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAY64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14089.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=DB237115; Type=Frameshift;
Positions=48;
Selected PDB 3D structures from and Proteopedia for PARP14 (see all 12):
3GOY (3D)        3Q6Z (3D)        3Q71 (3D)        3SE2 (3D)        3SMI (3D)        3SMJ (3D)    
Secondary accessions: B4E2H0 Q460N4 Q8J027 Q9H9X9 Q9NV60 Q9ULF2
Alternative splicing: 5 isoforms:  Q460N5-6   Q460N5-1   Q460N5-3   Q460N5-4   Q460N5-5   

Explore the universe of human proteins at neXtProt for PARP14: NX_Q460N5

Explore proteomics data for PARP14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys300, Lys518, Lys640, Lys747, Lys773, Lys924, Lys939, Lys967, Lys1122, Lys1201,
                                 Lys1319, Lys1435, Lys1508, Lys1589
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PARP14 (Q460N5)
     KIERIQN  PAIGTGN  GKGTYFA 


    See PARP14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060024.2  
    ENSEMBL proteins: 
     ENSP00000418194   ENSP00000418535   ENSP00000420649  

    PARP14 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PARP14

     
    Search eBioscience for Proteins for PARP14 

    PARP14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals PARP14 Antibodies
    Abcam antibodies for PARP14
    Cloud-Clone Corp. Antibodies for PARP14
    Search ThermoFisher Antibodies for PARP14
    LSBio Antibodies in human, mouse, rat for PARP14

    PARP14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PARP14
    Cloud-Clone Corp. CLIAs for PARP14
    Search eBioscience for ELISAs for PARP14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARP: Poly (ADP-ribose) polymerases

    3 InterPro protein domains:
     IPR004170 WWE-dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom
     IPR002589 Macro_dom

    Graphical View of Domain Structure for InterPro Entry Q460N5

    ProtoNet protein and cluster: Q460N5

    1 Blocks protein domain: IPB002589 Protein of unknown function Appr-1

    UniProtKB/Swiss-Prot: PAR14_HUMAN, Q460N5
    Similarity: Contains 3 Macro domains
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 WWE domain


    Find genes that share domains with PARP14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR14_HUMAN, Q460N5
    Function: Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

         Enzyme Number (IUBMB): EC 2.4.2.301 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PARP14           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PARP14:
     Cell division defect  Increased 8N DNA content  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARP14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARP14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARP14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARP14

    miRNA
    Products:
        
    miRTarBase miRNAs that target PARP14:
    hsa-mir-124-3p (MIRT022904)

    Block miRNA regulation of human, mouse, rat PARP14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARP14 (see all 9):
    hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-26b* hsa-miR-513c hsa-miR-125b hsa-miR-493* hsa-miR-514b-5p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidPARP14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PARP14
    Predesigned siRNA for gene silencing in human, mouse, rat PARP14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PARP14

    Clone
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    OriGene clones in human, mouse for PARP14 (see all 6)
    OriGene ORF clones in mouse, rat for PARP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARP14 (NM_017554)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP14

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PARP14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAR14_HUMAN, Q460N5: Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor
    proportion is detected in the cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----

    Find genes that share ontologies with PARP14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARP14 About    
    See pathways by source

    SuperPathContained pathways About
    1IL4-mediated signaling events
    IL4-mediated signaling events

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PARP14
        UVA-Induced MAPK Signaling
    Cellular Apoptosis Pathway
    Granzyme Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    1 BioSystems Pathway for PARP14
        IL4-mediated signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PARP14
    Interactions:

        Search GeneGlobe Interaction Network for PARP14

    5 Interacting proteins for PARP14 (Q460N53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPIP067443I2D: score=4 
    STAT6P422263I2D: score=2 
    FCER2P067343I2D: score=1 
    HDAC2Q927693I2D: score=1 
    HDAC3O153793I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with PARP14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PARP14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    1 HMDB Compound for PARP14    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PARP14 gene: 
    NM_017554.2  

    Unigene Cluster for PARP14:

    Poly (ADP-ribose) polymerase family, member 14
    Hs.518203  [show with all ESTs]
    Unigene Representative Sequence: BX648758
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474629(uc003efq.4 uc003efr.3) ENST00000494811 ENST00000483611
    ENST00000460683(uc021xdc.1 uc010hrk.3 uc003efs.1) ENST00000474669
    ENST00000475640
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PARP14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARP14 (see all 9):
    hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-26b* hsa-miR-513c hsa-miR-125b hsa-miR-493* hsa-miR-514b-5p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidPARP14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PARP14
    Predesigned siRNA for gene silencing in human, mouse, rat PARP14
    Clone
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    OriGene clones in human, mouse for PARP14 (see all 6)
    OriGene ORF clones in mouse, rat for PARP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARP14 (NM_017554)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP14
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PARP14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARP14
      QuantiTect SYBR Green Assays in human, mouse, rat PARP14
      QuantiFast Probe-based Assays in human, mouse, rat PARP14

    Additional mRNA sequence: 

    AB033094.1 AF026945.1 AK001770.1 AK022542.1 AK026003.1 AK027260.1 AK098816.1 AK304269.1 
    AY134858.1 BC032804.1 BC039604.1 BX648758.1 DQ063584.1 DQ063585.1 

    16 DOTS entries:

    DT.453057  DT.99992949  DT.95375170  DT.40132446  DT.100827822  DT.91792245  DT.91806635  DT.100649895 
    DT.100805958  DT.91705357  DT.95311151  DT.97772189  DT.120848381  DT.100734111  DT.205113  DT.40237278 

    Selected AceView cDNA sequences (see all 279):

    AA831239 N91697 AA456808 AB033094 AU133531 CA435587 BU679716 AI024459 
    AI373439 BQ421554 N58209 AW009526 AY134858 AW173354 AA250736 BF771187 
    AW664143 H04272 C01459 BU674913 AI611712 CA418912 CK903670 BG231805 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCCTTGTT
    PARP14 Expression
    About this image


    PARP14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PARP14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARP14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518203
        Custom PCR Arrays for PARP14
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PARP14 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Parp141 , 5 poly (ADP-ribose) polymerase family, member 141, 5 73.74(n)1
    64.15(a)1
      16 (25.43 cM)5
    5472531  NM_001039530.31  NP_001034619.21 
     358328745 
    chicken
    (Gallus gallus)
    Aves PARP141 poly (ADP-ribose) polymerase family, member 14 56.65(n)
    44.82(a)
      424266  XM_422113.4  XP_422113.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    49(a)
    42(a)
    many ↔ many
    many ↔ many
    1(77462137-77475312)
    1(77512205-77554564)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.198312 Xenopus laevis cDNA clone IMAGE4968464, partial cds 72.96(n)    BC059325.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570555282   -- 70.64(n)    57055528 


    ENSEMBL Gene Tree for PARP14 (if available)
    TreeFam Gene Tree for PARP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARP14 gene
    PARP152  PARP92  PARP112  PARP102  PARP122  TIPARP2  ZC3HAV12  
    1 SIMAP similar gene for PARP14 using alignment to 5 protein entries:     PAR14_HUMAN (see all proteins):
    PARP15

    Find genes that share paralogs with PARP14           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PARP14
    PGOHUM00000238155


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARP14 (see all 1063)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22800701,2
    C,F,H--122397717(-) AGTTAT/CTTTTG 1 -- us2k199Minor allele frequency- C:0.08EA NS WA NA PA EU CA CSA 7782
    rs756824601,2
    F--122397870(+) CGGTGG/TTAAGA 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs7901091,2
    C,F,O,H--122397886(-) AATTAT/GCGACA 1 -- us2k135Minor allele frequency- G:0.37EA NA NS WA 5004
    rs1882322041,2
    --122398087(+) AAGTCC/TGGCTG 1 -- us2k10--------
    rs1809835191,2
    --122398209(+) CTGTTA/TAGGAT 1 -- us2k10--------
    rs130615981,2
    C,F--122398366(+) GTTACG/CCTCTC 1 -- us2k16Minor allele frequency- C:0.13NA WA EA 246
    rs7968891,2
    C,F,O,H--122398461(-) TGCTGG/AGGAGC 1 -- us2k111Minor allele frequency- A:0.47NA WA CSA EA 374
    rs15120481,2
    C,F,A,H--122398478(-) AGAAGT/CGTCTG 1 -- us2k121Minor allele frequency- C:0.10NS EA NA WA 2562
    rs15120471,2
    C,F,A--122398524(-) GGGGCG/AGGGGG 1 -- us2k15Minor allele frequency- A:0.20WA CSA NA EA 362
    rs1861620401,2
    --122398527(+) CCCGCC/TCCCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARP14 (122399465 - 122449687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PARP14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268642CNV Insertion20981092
    esv273865CNV Insertion20981092
    nsv829705CNV Loss17160897
    nsv877391CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610028    OMIM disorders: --


    Find genes that share disorders with PARP14           About GenesLikeMe

    Genetic Association Database (GAD): PARP14

    Export disorders for PARP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PARP14 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PARP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1, 2 Kimura K.... Sugano S. (Genome Res. 2006)
    2. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PubMed id 16061477)1, 2 Aguiar R.C.T.... Shipp M.A. (J. Biol. Chem. 2005)
    3. The PARP superfamily. (PubMed id 15273990)1, 3 AmAc J.C....de Murcia G. (Bioessays 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    6. Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma. (PubMed id 23045269)1 Barbarulo A....Bubici C. (Oncogene 2013)
    7. Regulation of NF-I_B signalling by the mono-ADP-ribosyltransferase ARTD10. (PubMed id 23575687)1 Verheugd P....LA1scher B. (Nat Commun 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Frameshift mutations of poly(adenosine diphosphate-ribose) polymerase genes in gastric and colorectal cancers with microsatellite instability. (PubMed id 21333322)1 Kim M.S....Lee S.H. (Hum. Pathol. 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54625 HGNC: 29232 AceView: PARP14 Ensembl:ENSG00000173193 euGenes: HUgn54625
    ECgene: PARP14 H-InvDB: PARP14

    (According to HUGE)
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    HUGE: KIAA1268

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PARP14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PARP14 gene:
    Search GeneIP for patents involving PARP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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