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Aliases for PARP14 Gene

Aliases for PARP14 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 14 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 8 3 4
  • B Aggressive Lymphoma Protein 2 3 4
  • EC 2.4.2.30 4 58
  • PARP-14 3 4
  • ARTD8 3 4
  • BAL2 3 4
  • Poly [ADP-Ribose] Polymerase 14 3
  • B-Aggressive Lymphoma 2 3
  • Collaborator Of STAT6 3
  • KIAA1268 4
  • PART8 3

External Ids for PARP14 Gene

Previous GeneCards Identifiers for PARP14 Gene

  • GC03P123897
  • GC03P122399
  • GC03P119772

Summaries for PARP14 Gene

Entrez Gene Summary for PARP14 Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

GeneCards Summary for PARP14 Gene

PARP14 (Poly(ADP-Ribose) Polymerase Family Member 14) is a Protein Coding gene. Among its related pathways are Metabolism and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP15.

UniProtKB/Swiss-Prot for PARP14 Gene

  • Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.

Tocris Summary for PARP14 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Additional gene information for PARP14 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP14 Gene

Genomics for PARP14 Gene

Regulatory Elements for PARP14 Gene

Enhancers for PARP14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H122678 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.3 +0.7 680 5 HDGF SIN3A ZNF2 YY1 GLIS2 ZNF143 ZNF207 ATF7 RUNX3 YY2 PARP14 DTX3L PARP9 HSPBAP1 DIRC2 LINC02035 CSTA KPNA1
GH03H122766 1.3 FANTOM5 Ensembl ENCODE dbSUPER 31.1 +87.7 87704 3 POLR2A DIRC2 HSPBAP1 PARP14 PARP9 DTX3L LINC02035 CSTA KPNA1
GH03H122773 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +93.5 93523 1 CTCF PKNOX1 FOSL1 EED ATF7 IKZF2 SMARCA5 ZNF687 HLF NR2F1 PARP14 HSPBAP1 DTX3L PARP9 DIRC2 CSTA KPNA1
GH03H122770 0.9 FANTOM5 Ensembl dbSUPER 22.6 +90.0 90039 0 PARP14 DIRC2 HSPBAP1 PARP9 DTX3L CSTA KPNA1
GH03H122792 1.4 ENCODE dbSUPER 13.7 +113.8 113808 3 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF143 ZNF207 FOS ENSG00000273454 PARP14 IQCB1 SEC22A LOC102723582 LINC02035 HSPBAP1 DIRC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP14 on UCSC Golden Path with GeneCards custom track

Promoters for PARP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000305844 482 1801 SIN3A YY1 GLIS2 RUNX3 JUNB REST KAT8 SMARCA4 GLIS1 STAT3
ENSR00000157351 -1118 201 TBP HDGF SIN3A BATF ZNF2 ZSCAN9 RAD21 GLIS2 ZNF143 ZNF207

Genomic Location for PARP14 Gene

Chromosome:
3
Start:
122,680,618 bp from pter
End:
122,730,840 bp from pter
Size:
50,223 bases
Orientation:
Plus strand

Genomic View for PARP14 Gene

Genes around PARP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP14 Gene

Proteins for PARP14 Gene

  • Protein details for PARP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q460N5-PAR14_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 14
    Protein Accession:
    Q460N5
    Secondary Accessions:
    • B4E2H0
    • Q460N4
    • Q8J027
    • Q9H9X9
    • Q9NV60
    • Q9ULF2

    Protein attributes for PARP14 Gene

    Size:
    1801 amino acids
    Molecular mass:
    202800 Da
    Quaternary structure:
    • Interacts with STAT6 (By similarity). Interacts with PARP10 (PubMed:23473667).
    SequenceCaution:
    • Sequence=AAY64449.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14089.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DB237115; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP14 Gene

    Alternative splice isoforms for PARP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP14 Gene

Selected DME Specific Peptides for PARP14 Gene

Q460N5:
  • GKGTYFA
  • KIERIQN
  • PAIGTGN

Post-translational modifications for PARP14 Gene

  • Ubiquitination at posLast=300300, posLast=518518, posLast=640640, posLast=747747, posLast=773773, Lys924, Lys939, posLast=967967, posLast=11221122, posLast=12011201, Lys1319, posLast=14351435, posLast=15081508, and Lys1589
  • Modification sites at PhosphoSitePlus

Other Protein References for PARP14 Gene

Domains & Families for PARP14 Gene

Gene Families for PARP14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PARP14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP14: view

No data available for UniProtKB/Swiss-Prot for PARP14 Gene

Function for PARP14 Gene

Molecular function for PARP14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.

Enzyme Numbers (IUBMB) for PARP14 Gene

Phenotypes From GWAS Catalog for PARP14 Gene

Gene Ontology (GO) - Molecular Function for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IDA 27796300
GO:0005515 protein binding IPI 23473667
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP14: view
genes like me logo Genes that share phenotypes with PARP14: view

Animal Model Products

CRISPR Products

miRNA for PARP14 Gene

miRTarBase miRNAs that target PARP14

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARP14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP14 Gene

Localization for PARP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP14 Gene

Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP14 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 27796300
GO:0005829 cytosol IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PARP14: view

Pathways & Interactions for PARP14 Gene

genes like me logo Genes that share pathways with PARP14: view

Gene Ontology (GO) - Biological Process for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006471 protein ADP-ribosylation IDA 27796300
GO:0010629 negative regulation of gene expression IMP 27796300
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP 27796300
genes like me logo Genes that share ontologies with PARP14: view

No data available for SIGNOR curated interactions for PARP14 Gene

Drugs & Compounds for PARP14 Gene

(6) Drugs for PARP14 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 937,941
NAD Pharma Full agonist, Agonist 0
BYK 204165 Pharma PARP-1 inhibitor,potent and selective, Selective PARP-1 inhibitor 0
EB 47 Pharma Potent PARP-1 inhibitor 0
JW 55 Pharma PARP domain inhibitor, Tankyrase inhibitor 0

(1) Additional Compounds for PARP14 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP14 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3
genes like me logo Genes that share compounds with PARP14: view

Transcripts for PARP14 Gene

Unigene Clusters for PARP14 Gene

Poly (ADP-ribose) polymerase family, member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARP14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PARP14 Gene

No ASD Table

Relevant External Links for PARP14 Gene

GeneLoc Exon Structure for
PARP14
ECgene alternative splicing isoforms for
PARP14

Expression for PARP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP14 Gene

Protein differential expression in normal tissues from HIPED for PARP14 Gene

This gene is overexpressed in Lymph node (17.5), Lavage (12.8), Peripheral blood mononuclear cells (9.5), and Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP14 Gene



Protein tissue co-expression partners for PARP14 Gene

NURSA nuclear receptor signaling pathways regulating expression of PARP14 Gene:

PARP14

SOURCE GeneReport for Unigene cluster for PARP14 Gene:

Hs.518203

Evidence on tissue expression from TISSUES for PARP14 Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Lung(2.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PARP14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP14 Gene

Orthologs for PARP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP14 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia PARP14 33 34
  • 81.11 (n)
dog
(Canis familiaris)
Mammalia PARP14 33 34
  • 78.62 (n)
rat
(Rattus norvegicus)
Mammalia Parp14 33
  • 73.78 (n)
mouse
(Mus musculus)
Mammalia Parp14 33 16 34
  • 73.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PARP14 33
  • 56.65 (n)
-- 34
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732564 33
  • 51.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19831 33
zebrafish
(Danio rerio)
Actinopterygii parp14 33
  • 49.63 (n)
CABZ01031892.1 34
  • 34 (a)
ManyToMany
si:ch211-219a4.3 34
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToMany
Species where no ortholog for PARP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP14 Gene

ENSEMBL:
Gene Tree for PARP14 (if available)
TreeFam:
Gene Tree for PARP14 (if available)

Paralogs for PARP14 Gene

Paralogs for PARP14 Gene

(1) SIMAP similar genes for PARP14 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PARP14 Gene

genes like me logo Genes that share paralogs with PARP14: view

Variants for PARP14 Gene

Sequence variations from dbSNP and Humsavar for PARP14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs863223384 Benign 122,700,009(+) AGCAG(A/T)CTACT nc-transcript-variant, reference, missense
rs863223385 Benign 122,700,637(+) TCTGG(A/C)CAAAG nc-transcript-variant, reference, missense
rs1000007837 -- 122,703,196(+) TAGCC(C/T)GATTA intron-variant
rs1000069467 -- 122,693,558(+) ATAGG(C/G)CCAGG intron-variant
rs1000314909 -- 122,713,167(+) ATCAA(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP14 Gene

Variant ID Type Subtype PubMed ID
esv3304363 CNV mobile element insertion 20981092
esv3309593 CNV mobile element insertion 20981092
esv3370677 CNV insertion 20981092
nsv829705 CNV loss 17160897

Variation tolerance for PARP14 Gene

Residual Variation Intolerance Score: 3.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP14 Gene

Disorders for PARP14 Gene

Relevant External Links for PARP14

Genetic Association Database (GAD)
PARP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP14

No disorders were found for PARP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP14 Gene

Publications for PARP14 Gene

  1. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. (PMID: 23473667) Forst AH … Lüscher B (Structure (London, England : 1993) 2013) 3 4 60
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 4 60
  3. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PMID: 16061477) Aguiar RC … Shipp MA (The Journal of biological chemistry 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3 60

Products for PARP14 Gene

Sources for PARP14 Gene

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