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Aliases for PARP14 Gene

Aliases for PARP14 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 14 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 8 3 4
  • B Aggressive Lymphoma Protein 2 3 4
  • EC 2.4.2.30 4 63
  • PARP-14 3 4
  • ARTD8 3 4
  • BAL2 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 14 3
  • B-Aggressive Lymphoma 2 3
  • Collaborator Of STAT6 3
  • KIAA1268 4
  • PART8 3

External Ids for PARP14 Gene

Previous GeneCards Identifiers for PARP14 Gene

  • GC03P123897
  • GC03P122399
  • GC03P119772

Summaries for PARP14 Gene

Entrez Gene Summary for PARP14 Gene

  • Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PARP14 Gene

PARP14 (Poly(ADP-Ribose) Polymerase Family Member 14) is a Protein Coding gene. Among its related pathways are IL4-mediated signaling events and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP11.

UniProtKB/Swiss-Prot for PARP14 Gene

  • Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.

Tocris Summary for PARP14 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP14 Gene

Genomics for PARP14 Gene

Regulatory Elements for PARP14 Gene

Promoters for PARP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARP14 on UCSC Golden Path with GeneCards custom track

Genomic Location for PARP14 Gene

Chromosome:
3
Start:
122,680,618 bp from pter
End:
122,730,840 bp from pter
Size:
50,223 bases
Orientation:
Plus strand

Genomic View for PARP14 Gene

Genes around PARP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP14 Gene

Proteins for PARP14 Gene

  • Protein details for PARP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q460N5-PAR14_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 14
    Protein Accession:
    Q460N5
    Secondary Accessions:
    • B4E2H0
    • Q460N4
    • Q8J027
    • Q9H9X9
    • Q9NV60
    • Q9ULF2

    Protein attributes for PARP14 Gene

    Size:
    1801 amino acids
    Molecular mass:
    202800 Da
    Quaternary structure:
    • Interacts with STAT6.
    SequenceCaution:
    • Sequence=AAY64449.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14089.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DB237115; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP14 Gene

    Alternative splice isoforms for PARP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP14 Gene

Proteomics data for PARP14 Gene at MOPED

Selected DME Specific Peptides for PARP14 Gene

Post-translational modifications for PARP14 Gene

  • Ubiquitination at Lys 300, Lys 518, Lys 640, Lys 747, Lys 773, Lys 924, Lys 939, Lys 967, Lys 1122, Lys 1201, Lys 1319, Lys 1435, Lys 1508, and Lys 1589
  • Modification sites at PhosphoSitePlus

Other Protein References for PARP14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PARP14 Gene

Gene Families for PARP14 Gene

Protein Domains for PARP14 Gene

Suggested Antigen Peptide Sequences for PARP14 Gene

Graphical View of Domain Structure for InterPro Entry

Q460N5

UniProtKB/Swiss-Prot:

PAR14_HUMAN :
  • Contains 3 Macro domains.
Domain:
  • Contains 3 Macro domains.
  • Contains 1 PARP catalytic domain.
  • Contains 1 WWE domain.
genes like me logo Genes that share domains with PARP14: view

Function for PARP14 Gene

Molecular function for PARP14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.

Enzyme Numbers (IUBMB) for PARP14 Gene

genes like me logo Genes that share phenotypes with PARP14: view

Animal Model Products

miRNA for PARP14 Gene

miRTarBase miRNAs that target PARP14

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP14 Gene

Localization for PARP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP14 Gene

Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP14 Gene COMPARTMENTS Subcellular localization image for PARP14 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PARP14: view

Pathways & Interactions for PARP14 Gene

genes like me logo Genes that share pathways with PARP14: view

Pathways by source for PARP14 Gene

Gene Ontology (GO) - Biological Process for PARP14 Gene

None

No data available for SIGNOR curated interactions for PARP14 Gene

Drugs & Compounds for PARP14 Gene

(3) Drugs for PARP14 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 353,361
NU1025 Experimental Pharma Potent PARP inhibitor 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for PARP14 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7
genes like me logo Genes that share compounds with PARP14: view

Transcripts for PARP14 Gene

Unigene Clusters for PARP14 Gene

Poly (ADP-ribose) polymerase family, member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP14 Gene

No ASD Table

Relevant External Links for PARP14 Gene

GeneLoc Exon Structure for
PARP14
ECgene alternative splicing isoforms for
PARP14

Expression for PARP14 Gene

mRNA expression in normal human tissues for PARP14 Gene

Protein differential expression in normal tissues from HIPED for PARP14 Gene

This gene is overexpressed in Lymph node (17.5), Lavage (12.8), Peripheral blood mononuclear cells (9.5), and Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP14 Gene



SOURCE GeneReport for Unigene cluster for PARP14 Gene Hs.518203

genes like me logo Genes that share expression patterns with PARP14: view

Protein tissue co-expression partners for PARP14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PARP14 Gene

Orthologs for PARP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP14 36
  • 99 (a)
OneToOne
PARP14 35
  • 99.35 (n)
  • 98.83 (a)
cow
(Bos Taurus)
Mammalia PARP14 36
  • 71 (a)
OneToOne
PARP14 35
  • 81.11 (n)
  • 70.94 (a)
dog
(Canis familiaris)
Mammalia PARP14 35
  • 78.62 (n)
  • 68.83 (a)
PARP14 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp14 16
Parp14 35
  • 73.74 (n)
  • 64.15 (a)
Parp14 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Parp14 35
  • 73.78 (n)
  • 63.98 (a)
chicken
(Gallus gallus)
Aves PARP14 35
  • 56.65 (n)
  • 44.82 (a)
-- 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.19831 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732564 35
  • 51.56 (n)
  • 40.87 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01031892.1 36
  • 34 (a)
ManyToMany
si:ch211-219a4.3 36
  • 33 (a)
ManyToMany
parp14 35
  • 49.63 (n)
  • 37.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for PARP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP14 Gene

ENSEMBL:
Gene Tree for PARP14 (if available)
TreeFam:
Gene Tree for PARP14 (if available)

Paralogs for PARP14 Gene

Paralogs for PARP14 Gene

(1) SIMAP similar genes for PARP14 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PARP14 Gene

genes like me logo Genes that share paralogs with PARP14: view

Variants for PARP14 Gene

Sequence variations from dbSNP and Humsavar for PARP14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs812046 -- 122,697,578(+) GCAGA(C/T)GGTAG intron-variant
rs930123 -- 122,714,715(+) AGAGA(A/G)TGGAA intron-variant
rs1256199 -- 122,693,111(+) ATGGA(C/T)gaact intron-variant
rs1256200 -- 122,694,054(+) gggca(C/T)agaga intron-variant
rs1262253 -- 122,685,710(+) tcacc(A/T)tattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP14 Gene

Variant ID Type Subtype PubMed ID
nsv877391 CNV Gain 21882294
nsv829705 CNV Loss 17160897
esv273865 CNV Insertion 20981092
esv268642 CNV Insertion 20981092

Variation tolerance for PARP14 Gene

Residual Variation Intolerance Score: 3.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP14 Gene

HapMap Linkage Disequilibrium report
PARP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP14 Gene

Disorders for PARP14 Gene

Relevant External Links for PARP14

Genetic Association Database (GAD)
PARP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP14

No disorders were found for PARP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP14 Gene

Publications for PARP14 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 4 67
  2. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3
  3. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  4. A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress. (PMID: 25753673) Nicolae C.M. … Moldovan G.L. (Nucleic Acids Res. 2015) 3
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3

Products for PARP14 Gene

Sources for PARP14 Gene

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