Aliases for PARP14 Gene
External Ids for PARP14 Gene
Previous GeneCards Identifiers for PARP14 Gene
Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PARP14 Gene
PARP14 (Poly (ADP-Ribose) Polymerase Family, Member 14) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and IL4-mediated signaling events. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP11.
UniProtKB/Swiss-Prot for PARP14 Gene
Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes, stroke and cardiovascular disease.