Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PARP12 Gene

protein-coding   GIFtS: 58
GCID: GC07M139723

Poly (ADP-Ribose) Polymerase Family, Member 12

(Previous name: zinc finger CCCH-type domain containing 1)
(Previous symbol: ZC3HDC1)
  Search for PARP12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Poly (ADP-Ribose) Polymerase Family, Member 121 2     MSTP1092
ZC3HDC11 2 3 5     ZC3H12
Zinc Finger CCCH Domain-Containing Protein 12 3     Poly [ADP-Ribose] Polymerase 122
ARTD122 3     Zinc Finger CCCH Type Domain Containing 12
ADP-Ribosyltransferase Diphtheria Toxin-Like 122 3     EC 2.4.2.303
Zinc Finger CCCH-Type Domain Containing 11     PARP-123
MST1092     FLJ226935

External Ids:    HGNC: 219191   Entrez Gene: 647612   Ensembl: ENSG000000593787   OMIM: 6124815   UniProtKB: Q9H0J93   

Export aliases for PARP12 gene to outside databases

Previous GC identifers: GC07M139177 GC07M139370 GC07M134017


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PARP12 Gene:
PARP12 (poly (ADP-ribose) polymerase family, member 12) is a protein-coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP15.

summary for PARP12 Gene:
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the
addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to
glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain
polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,
stroke and cardiovascular disease.

Gene Wiki entry for PARP12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARP12 gene promoter:
         RP58   AP-4   POU2F1   E2F   E2F-1   POU2F1a   Zic1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PARP12 promoter sequence
   Search Chromatin IP Primers for PARP12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PARP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARP12 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M139723:  view genomic region     (about GC identifiers)

Start:
139,723,544 bp from pter      End:
139,763,521 bp from pter
Size:
39,978 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 139,052,388-139,092,369     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PAR12_HUMAN, Q9H0J9 (See protein sequence)
Recommended Name: Poly [ADP-ribose] polymerase 12  
Size: 701 amino acids; 79064 Da
1 PDB 3D structure from and Proteopedia for PARP12:
2PQF (3D)    
Secondary accessions: Q9H610 Q9NP36 Q9NTI3

Explore the universe of human proteins at neXtProt for PARP12: NX_Q9H0J9

Explore proteomics data for PARP12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys256, Lys308, Lys477
  • Modification sites at PhosphoSitePlus (PARP12)

  • See PARP12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073587.1  
    ENSEMBL proteins: 
     ENSP00000263549   ENSP00000417730   ENSP00000417606   ENSP00000418105   ENSP00000418640  

    PARP12 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PARP12
    GenScript Custom Purified and Recombinant Proteins Services for PARP12
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PARP12

     
    Search eBioscience for Proteins for PARP12 

    PARP12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PARP12
    Novus Biologicals PARP12 Antibodies
    Abcam antibodies for PARP12
    Cloud-Clone Corp. Antibodies for PARP12
    ThermoFisher Antibodies for PARP12
    LSBio Antibodies in human, mouse, rat for PARP12

    PARP12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PARP12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PARP12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PARP12
    Cloud-Clone Corp. CLIAs for PARP12
    Search eBioscience for ELISAs for PARP12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PARP: Poly (ADP-ribose) polymerases
    ZC3H: Zinc fingers, CCCH-type domain containing

    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR004170 WWE-dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H0J9

    ProtoNet protein and cluster: Q9H0J9

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: PAR12_HUMAN, Q9H0J9
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 2 WWE domains


    Find genes that share domains with PARP12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR12_HUMAN, Q9H0J9
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PARP12           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PARP12:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Parp12 (no phenotypes)

    Find genes that share phenotypes with PARP12           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARP12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARP12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARP12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARP12

    miRNA
    Products:
        
    miRTarBase miRNAs that target PARP12:
    hsa-mir-98-5p (MIRT027561)

    Block miRNA regulation of human, mouse, rat PARP12 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PARP12:
    hsa-miR-3163 hsa-miR-587 hsa-miR-199a-5p hsa-miR-3658 hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidPARP12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PARP12
    Predesigned siRNA for gene silencing in human, mouse, rat PARP12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PARP12

    Clone
    Products:
         
    OriGene clones in human, mouse for PARP12 (see all 6)
    OriGene ORF clones in mouse, rat for PARP12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARP12 (NM_022750)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP12

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PARP12
    Browse ESI BIO Cell Lines and PureStem Progenitors for PARP12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PAR12_HUMAN, Q9H0J9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with PARP12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PARP12
    Interactions:

        Search GeneGlobe Interaction Network for PARP12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for PARP12 (Q9H0J93 ENSP000002635494) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    MLH1P406923I2D: score=1 
    CBX2ENSP000003087504STRING: ENSP00000308750
    HDAC2ENSP000003813314STRING: ENSP00000381331
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PARP12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    1 HMDB Compound for PARP12    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PARP12 gene: 
    NM_022750.2  

    Unigene Cluster for PARP12:

    Poly (ADP-ribose) polymerase family, member 12
    Hs.12646  [show with all ESTs]
    Unigene Representative Sequence: BC081541
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263549(uc003vvl.1 uc010lnf.1) ENST00000473341 ENST00000488726
    ENST00000489809 ENST00000491598 ENST00000484111 ENST00000496624 ENST00000489383
    ENST00000466597 ENST00000470515 ENST00000493262 ENST00000467638
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PARP12 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PARP12:
    hsa-miR-3163 hsa-miR-587 hsa-miR-199a-5p hsa-miR-3658 hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidPARP12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PARP12
    Predesigned siRNA for gene silencing in human, mouse, rat PARP12
    Clone
    Products:
         
    OriGene clones in human, mouse for PARP12 (see all 6)
    OriGene ORF clones in mouse, rat for PARP12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARP12 (NM_022750)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP12
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PARP12
    OriGene qSTAR qPCR primer pairs in human, mouse for PARP12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARP12
      QuantiTect SYBR Green Assays in human, mouse, rat PARP12
      QuantiFast Probe-based Assays in human, mouse, rat PARP12

    Additional mRNA sequence: 

    AF173884.1 AK026346.1 AL136766.1 AL137255.1 BC044660.1 BC081541.1 

    15 DOTS entries:

    DT.100819927  DT.100819928  DT.114897  DT.101982550  DT.65285853  DT.91805316  DT.75136025  DT.91767054 
    DT.91994453  DT.97858931  DT.100819930  DT.95372098  DT.95372100  DT.121043103  DT.97804361 

    Selected AceView cDNA sequences (see all 151):

    CD742716 AL557946 BQ016968 BX107920 NM_022750 AA804802 CA439292 CA308105 
    AL137255 BQ439056 AA242843 CD364524 BQ425387 AI953622 BE858326 AI342235 
    AI273746 T80116 CR617533 BC081541 AI383960 CR602813 BU526662 AI126027 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PARP12 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
    SP1:                    -     -                                               -           -     -                                   -               
    SP2:                                                  -     -     -           -           -     -                 -     -           -               
    SP3:              -     -     -     -     -     -     -                       -           -     -                                                   
    SP4:                                                  -     -     -     -     -           -     -                 -     -                           
    SP5:                                                                          -                                                                     


    ECgene alternative splicing isoforms for PARP12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PARP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACAAAAGA
    PARP12 Expression
    About this image


    PARP12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
    PARP12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARP12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12646
        Custom PCR Arrays for PARP12
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PARP12
    OriGene qSTAR qPCR primer pairs in human, mouse for PARP12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARP12
    QuantiTect SYBR Green Assays in human, mouse, rat PARP12
    QuantiFast Probe-based Assays in human, mouse, rat PARP12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PARP12 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Parp121 , 5 poly (ADP-ribose) polymerase family, member 121, 5 82.88(n)1
    81.31(a)1
      6 (17.85 cM)5
    2437711  NM_172893.31  NP_766481.21 
     390864105 
    chicken
    (Gallus gallus)
    Aves PARP121 poly (ADP-ribose) polymerase family, member 12 61.96(n)
    56.44(a)
      418100  XM_416333.4  XP_416333.4 
    lizard
    (Anolis carolinensis)
    Reptilia PARP126
    poly (ADP-ribose) polymerase family, member 12
    55(a)
    1 ↔ 1
    5(17158052-17180931)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124142 Xenopus laevis transcribed sequence with weak similarity more 75.96(n)    BJ086228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii parp12a1 poly (ADP-ribose) polymerase family, member 12a 55.61(n)
    50.17(a)
      567195  NM_001082852.1  NP_001076321.1 


    ENSEMBL Gene Tree for PARP12 (if available)
    TreeFam Gene Tree for PARP12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PARP12 gene
    PARP152  PARP92  PARP112  PARP102  PARP142  TIPARP2  ZC3HAV12  
    4 SIMAP similar genes for PARP12 using alignment to 5 protein entries:     PAR12_HUMAN (see all proteins):
    ZC3HDC1    TIPARP    PARP15    ZC3HAV1L

    Find genes that share paralogs with PARP12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PARP12 (see all 977)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818547031,2
    --139723066(+) GGGGAC/GGGGCT 1 -- int10--------
    rs1865397891,2
    --139723073(+) GGCTCA/CAGCAA 1 -- int10--------
    rs1485183211,2
    --139723094(+) CTGAAC/TCTTCA 1 -- int10--------
    rs1475771131,2
    C--139723154(+) ATCAG-/CTCTGTC 1 -- int10--------
    rs1898053581,2
    --139723359(+) GAAGCA/TGGAGG 1 -- int10--------
    rs22699971,2
    C,F,A,H--139723400(-) GCAGAC/TGTTTA 1 -- int133Minor allele frequency- T:0.42NS EA NA WA CSA 3202
    rs1418834351,2
    --139723593(+) CATGTA/GTGGCA 1 -- ut310--------
    rs1830304531,2
    --139723594(+) ATGTGC/TGGCAC 1 -- ut310--------
    rs10447181,2
    C,F,A,H--139723596(-) TTGTGC/TCACAC 1 -- ut31 ese322Minor allele frequency- T:0.05NA NS EA WA 2454
    rs1460993581,2
    --139723659(+) GCTTAG/TGAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PARP12 (139723544 - 139763521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PARP12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    esv2735240CNV Deletion23290073
    esv2735237CNV Deletion23290073
    esv2735241CNV Deletion23290073
    esv2735238CNV Deletion23290073
    nsv824318CNV Loss20364138
    nsv889246CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PARP12
    DNA2.0 Custom Variant and Variant Library Synthesis for PARP12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612481    OMIM disorders: --


    Find genes that share disorders with PARP12           About GenesLikeMe

    Genetic Association Database (GAD): PARP12
    Human Genome Epidemiology (HuGE) Navigator: PARP12 (1 document)

    Export disorders for PARP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PARP12 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with PARP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PubMed id 12851707)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    3. Candidate gene polymorphisms for ischemic stroke. (PubMed id 19729601)1, 4 Matarin M....Meschia J.F. ( a journal of cerebral circulation 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64761 HGNC: 21919 AceView: ZC3HDC1 Ensembl:ENSG00000059378 euGenes: HUgn64761
    ECgene: PARP12 H-InvDB: PARP12

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PARP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PARP12 gene:
    Search GeneIP for patents involving PARP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PARP12  
     OriGene qPCR primer pairs and template standards for PARP12   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PARP12  
     OriGene qSTAR qPCR primer pairs in human, mouse for PARP12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PARP12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PARP12   OriGene Custom Protein Services for PARP12  

     
     
     Block miRNA regulation of human, mouse, rat PARP12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PARP12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARP12 Predesigned siRNA for gene silencing in human, mouse, rat PARP12
     QuantiFast Probe-based Assays in human, mouse, rat PARP12 QuantiTect SYBR Green Assays in human, mouse, rat PARP12
     Custom PCR Arrays for PARP12 Search Chromatin IP Primers for PARP12
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARP12  Search GeneGlobe Interaction Network for PARP12
     Regulatory tfbs in PARP12 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PARP12 GenScript cDNA clones with any tag delivered in your preferred vector for PARP12
     GenScript Custom Assay Services for PARP12 GenScript Custom overexpressing Cell Line Services for PARP12
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PARP12
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PARP12 antibodies
     Antibodies for PARP12
     See all of Abcam's Antibodies, Kits and Proteins for PARP12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PARP12
     Antibodies for PARP12
     ELISAs for PARP12
     CLIAs for PARP12



     Browse ESI BIO Cell Lines and PureStem Progenitors for PARP12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP12
     SwitchGear 3'UTR luciferase reporter plasmids for PARP12
     SwitchGear Promoter luciferase reporter plasmids for PARP12
     ThermoFisher Antibodies for PARP12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP12
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARP12
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARP12
     LSBio Antibodies in human, mouse, rat for PARP12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PARP12
      Search eBioscience for proteins for PARP12
      Search eBioscience for elisas for PARP12
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PARP12 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4