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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PARP12 Gene

protein-coding   GIFtS: 56
GCID: GC07M139723

Poly (ADP-Ribose) Polymerase Family, Member 12

(Previous name: zinc finger CCCH-type domain containing 1)
(Previous symbol: ZC3HDC1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Poly (ADP-Ribose) Polymerase Family, Member 121 2     MSTP1092
ZC3HDC11 2 3 5     ZC3H12
Zinc Finger CCCH Domain-Containing Protein 12 3     Poly [ADP-Ribose] Polymerase 122
ARTD122 3     Zinc Finger CCCH Type Domain Containing 12
ADP-Ribosyltransferase Diphtheria Toxin-Like 122 3     EC 2.4.2.303
Zinc Finger CCCH-Type Domain Containing 11     PARP-123
MST1092     FLJ226935

External Ids:    HGNC: 219191   Entrez Gene: 647612   Ensembl: ENSG000000593787   OMIM: 6124815   UniProtKB: Q9H0J93   

Export aliases for PARP12 gene to outside databases

Previous GC identifers: GC07M139177 GC07M139370 GC07M134017


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PARP12 Gene: 
PARP12 (poly (ADP-ribose) polymerase family, member 12) is a protein-coding gene. Diseases associated with PARP12 include diphtheria. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and nucleic acid binding. An important paralog of this gene is PARP15.

summary for PARP12 Gene:
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the
addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to
glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain
polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,
stroke and cardiovascular disease.

Gene Wiki entry for PARP12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PARP12 gene promoter:
         RP58   AP-4   POU2F1   E2F   E2F-1   POU2F1a   Zic1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PARP12 promoter sequence
   Search SABiosciences Chromatin IP Primers for PARP12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PARP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARP12 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M139723:  view genomic region     (about GC identifiers)

Start:
139,723,544 bp from pter      End:
139,763,521 bp from pter
Size:
39,978 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 139,052,388-139,092,369     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAR12_HUMAN, Q9H0J9 (See protein sequence)
Recommended Name: Poly [ADP-ribose] polymerase 12  
Size: 701 amino acids; 79064 Da
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for PARP12:
2PQF (3D)    
Secondary accessions: Q9H610 Q9NP36 Q9NTI3

Explore the universe of human proteins at neXtProt for PARP12: NX_Q9H0J9

Explore proteomics data for PARP12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus (PARP12)
  • View neXtProt modification sites for NX_Q9H0J9

  • PARP12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PARP12 Protein Expression
    REFSEQ proteins: NP_073587.1  
    ENSEMBL proteins: 
     ENSP00000263549   ENSP00000417730   ENSP00000417606   ENSP00000418105   ENSP00000418640  

    Human Recombinant Protein Products for PARP12: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PARP12
    GenScript Custom Purified and Recombinant Proteins Services for PARP12
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PARP12 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    PARP12 for ontologies           About GeneDecksing



    PARP12 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for PARP12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PARP: Poly (ADP-ribose) polymerases
    ZC3H: Zinc fingers, CCCH-type domain containing

    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR004170 WWE-dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H0J9

    ProtoNet protein and cluster: Q9H0J9

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: PAR12_HUMAN, Q9H0J9
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 2 WWE domains


    PARP12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR12_HUMAN, Q9H0J9
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    PARP12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PARP12:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PARP12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PARP12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARP12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARP12 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARP12
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PARP12:
    hsa-miR-3163 hsa-miR-587 hsa-miR-199a-5p hsa-miR-3658 hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidPARP12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PARP12
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PARP12

    Clone
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    GenScript: all cDNA clones in your preferred vector: PARP12 (NM_022750)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP12
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                         Customized lentivirus expression plasmids for stable overexpression of PARP12 

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    Search LifeMap BioReagents cell lines for PARP12
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PARP12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for PARP12 (Q9H0J93 ENSP000002635494) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    MLH1P406923I2D: score=1 
    CBX2ENSP000003087504STRING: ENSP00000308750
    HDAC2ENSP000003813314STRING: ENSP00000381331
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PARP12:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PARP12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    1 HMDB Compound for PARP12    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    Search CenterWatch for drugs/clinical trials and news about PARP12 / PAR12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PARP12 gene: 
    NM_022750.2  

    Unigene Cluster for PARP12:

    Poly (ADP-ribose) polymerase family, member 12
    Hs.12646  [show with all ESTs]
    Unigene Representative Sequence: BC081541
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263549(uc003vvl.1 uc010lnf.1) ENST00000473341 ENST00000488726
    ENST00000489809 ENST00000491598 ENST00000484111 ENST00000496624 ENST00000489383
    ENST00000466597 ENST00000470515 ENST00000493262 ENST00000467638
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARP12
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PARP12:
    hsa-miR-3163 hsa-miR-587 hsa-miR-199a-5p hsa-miR-3658 hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidPARP12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PARP12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PARP12
    Clone
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    OriGene clones in human, mouse for PARP12 (see all 5)
    OriGene ORF clones in mouse, rat for PARP12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARP12 (NM_022750)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP12
    Sirion Biotech Customized lentivirus for stable overexpression of PARP12 
                         Customized lentivirus expression plasmids for stable overexpression of PARP12 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PARP12
    OriGene qSTAR qPCR primer pairs in human, mouse for PARP12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PARP12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARP12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARP12

    Additional mRNA sequence: 

    AF173884.1 AK026346.1 AL136766.1 AL137255.1 BC044660.1 BC081541.1 

    15 DOTS entries:

    DT.100819927  DT.100819928  DT.114897  DT.101982550  DT.65285853  DT.91805316  DT.75136025  DT.91767054 
    DT.91994453  DT.97858931  DT.100819930  DT.95372098  DT.95372100  DT.121043103  DT.97804361 

    24/151 AceView cDNA sequences (see all 151):

    CA439292 BE503242 BM461734 CA308105 AI383960 BC081541 BQ439056 BU632968 
    AI342235 BE858326 BX107920 T80116 CD364524 AI126027 AI273746 AA330816 
    AA242843 AI953340 CR617533 CR602813 BQ016968 AI695480 BU526662 AL557946 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PARP12 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
    SP1:                    -     -                                               -           -     -                                   -               
    SP2:                                                  -     -     -           -           -     -                 -     -           -               
    SP3:              -     -     -     -     -     -     -                       -           -     -                                                   
    SP4:                                                  -     -     -     -     -           -     -                 -     -                           
    SP5:                                                                          -                                                                     


    ECgene alternative splicing isoforms for PARP12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARP12 expression in normal human tissues (normalized intensities)      PARP12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACAAAAGA
    PARP12 Expression
    About this image


    PARP12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See PARP12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PARP12

    SOURCE GeneReport for Unigene cluster: Hs.12646
        SABiosciences Custom PCR Arrays for PARP12
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARP12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PARP12 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Parp121 , 5 poly (ADP-ribose) polymerase family, member 121, 5 82.88(n)1
    81.31(a)1
      6 (17.85 cM)5
    2437711  NM_172893.31  NP_766481.21 
     390864105 
    chicken
    (Gallus gallus)
    Aves PARP121 poly (ADP-ribose) polymerase family, member 12 62.42(n)
    57.06(a)
      418100  XM_416333.3  XP_416333.3 
    lizard
    (Anolis carolinensis)
    Reptilia PARP126
    poly (ADP-ribose) polymerase family, member 12
    54(a)
    1 ↔ 1
    5(17158052-17180931)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124142 Xenopus laevis transcribed sequence with weak similarity more 75.96(n)    BJ086228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii parp12a1 poly (ADP-ribose) polymerase family, member 12a 54.37(n)
    48.24(a)
      567195  NM_001082852.1  NP_001076321.1 


    ENSEMBL Gene Tree for PARP12 (if available)
    TreeFam Gene Tree for PARP12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PARP12 gene
    PARP152  PARP92  PARP112  PARP102  PARP142  ZC3HAV12  TIPARP2  
    4 SIMAP similar genes for PARP12 using alignment to 5 protein entries:     PAR12_HUMAN (see all proteins):
    ZC3HDC1    TIPARP    PARP15    ZC3HAV1L

    PARP12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/977 SNPs in PARP12 are shown (see all 977)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818547031,2
    --139723066(+) GGGGAC/GGGGCT 1 -- int10--------
    rs1865397891,2
    --139723073(+) GGCTCA/CAGCAA 1 -- int10--------
    rs1485183211,2
    --139723094(+) CTGAAC/TCTTCA 1 -- int10--------
    rs1475771131,2
    C--139723154(+) ATCAG-/CTCTGTC 1 -- int10--------
    rs1898053581,2
    --139723359(+) GAAGCA/TGGAGG 1 -- int10--------
    rs22699971,2
    C,F,A,H--139723400(-) GCAGAC/TGTTTA 1 -- int133Minor allele frequency- T:0.42NS EA NA WA CSA 3202
    rs1418834351,2
    --139723593(+) CATGTA/GTGGCA 1 -- ut310--------
    rs1830304531,2
    --139723594(+) ATGTGC/TGGCAC 1 -- ut310--------
    rs10447181,2
    C,F,A,H--139723596(-) TTGTGC/TCACAC 1 -- ut31 ese322Minor allele frequency- T:0.05NA NS EA WA 2454
    rs1460993581,2
    --139723659(+) GCTTAG/TGAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PARP12 (139723544 - 139763521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PARP12:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    esv2735240CNV Deletion23290073
    esv2735237CNV Deletion23290073
    esv2735241CNV Deletion23290073
    esv2735238CNV Deletion23290073
    nsv824318CNV Loss20364138
    nsv889246CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612481    OMIM disorders: --

    2 diseases for PARP12:    About MalaCards
    diphtheria    


    PARP12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PARP12
    Human Genome Epidemiology (HuGE) Navigator: PARP12 (1 document)

    Export disorders for PARP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARP12 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with PARP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PubMed id 12851707)1, 3, 9 Katoh M. and Katoh M. (2003)
    3. Candidate gene polymorphisms for ischemic stroke. (PubMed id 19729601)1, 4 Matarin M....Meschia J.F. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1 Vandamme J.... Angrand P.O. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64761 HGNC: 21919 AceView: ZC3HDC1 Ensembl:ENSG00000059378 euGenes: HUgn64761
    ECgene: PARP12 H-InvDB: PARP12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PARP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PARP12 gene:
    Search GeneIP for patents involving PARP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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