Aliases for PARP10 Gene
External Ids for PARP10 Gene
Previous GeneCards Identifiers for PARP10 Gene
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PARP10 Gene
PARP10 (Poly(ADP-Ribose) Polymerase Family Member 10) is a Protein Coding gene. Diseases associated with PARP10 include Arts Syndrome. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include nucleotide binding and K63-linked polyubiquitin binding. An important paralog of this gene is PARP14.
UniProtKB/Swiss-Prot for PARP10 Gene
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.