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Aliases for PARP10 Gene

Aliases for PARP10 Gene

  • Poly (ADP-Ribose) Polymerase Family, Member 10 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 10 3 4
  • PARP-10 3 4
  • ARTD10 3 4
  • EC 2.4.2.30 4

External Ids for PARP10 Gene

Previous GeneCards Identifiers for PARP10 Gene

  • GC08M145123
  • GC08M145051
  • GC08M140305

Summaries for PARP10 Gene

Entrez Gene Summary for PARP10 Gene

  • Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PARP10 Gene

PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and K63-linked polyubiquitin binding. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP10 Gene

  • May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.

Tocris Summary for PARP10 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP10 Gene

Genomics for PARP10 Gene

Regulatory Elements for PARP10 Gene

Transcription factor binding sites by QIAGEN in the PARP10 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PARP10 Gene

Chromosome:
8
Start:
143,977,152 bp from pter
End:
144,012,772 bp from pter
Size:
35,621 bases
Orientation:
Minus strand

Genomic View for PARP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP10 Gene

Proteins for PARP10 Gene

  • Protein details for PARP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GL7-PAR10_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 10
    Protein Accession:
    Q53GL7
    Secondary Accessions:
    • Q8N2I0
    • Q8WV05
    • Q96CH7
    • Q96K72

    Protein attributes for PARP10 Gene

    Size:
    1025 amino acids
    Molecular mass:
    109998 Da
    Quaternary structure:
    • Interacts with MYC.
    SequenceCaution:
    • Sequence=BAC11498.1; Type=Frameshift; Positions=965; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP10 Gene

neXtProt entry for PARP10 Gene

Proteomics data for PARP10 Gene at MOPED

Post-translational modifications for PARP10 Gene

  • Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.
  • Ubiquitination at Lys 426, Lys 436, Lys 814, Lys 916, and Lys 941
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PARP10 Gene

Domains & Families for PARP10 Gene

Gene Families for PARP10 Gene

Protein Domains for PARP10 Gene

Suggested Antigen Peptide Sequences for PARP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q53GL7

UniProtKB/Swiss-Prot:

PAR10_HUMAN :
  • Contains 1 PARP catalytic domain.
Domain:
  • Contains 1 PARP catalytic domain.
genes like me logo Genes that share domains with PARP10: view

Function for PARP10 Gene

Molecular function for PARP10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.

Enzyme Numbers (IUBMB) for PARP10 Gene

Gene Ontology (GO) - Molecular Function for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003950 NAD+ ADP-ribosyltransferase activity IMP 23575687
GO:0005515 protein binding IPI 15674325
GO:0070530 K63-linked polyubiquitin binding IMP 23575687
genes like me logo Genes that share ontologies with PARP10: view
genes like me logo Genes that share phenotypes with PARP10: view

Animal Models for PARP10 Gene

MGI Knock Outs for PARP10:

Animal Model Products

miRNA for PARP10 Gene

miRTarBase miRNAs that target PARP10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PARP10

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PARP10 Gene

Localization for PARP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP10 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP10 Gene COMPARTMENTS Subcellular localization image for PARP10 gene
Compartment Confidence
nucleus 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15674325
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 15674325
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with PARP10: view

Pathways & Interactions for PARP10 Gene

SuperPathways for PARP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IMP 23575687
GO:0008152 metabolic process --
GO:0010629 negative regulation of gene expression IMP 23575687
GO:0010847 regulation of chromatin assembly IDA 15674325
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 23575687
genes like me logo Genes that share ontologies with PARP10: view

No data available for Pathways by source and SIGNOR curated interactions for PARP10 Gene

Drugs & Compounds for PARP10 Gene

(8) Drugs for PARP10 Gene - From: HMDB, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
INO-1001 Experimental Pharma Inhibition, Inhibitor Potent PARP inhibitor 0
Nicotinamide Experimental Nutra 332,340
NU1025 Experimental Pharma Potent PARP inhibitor 0
AG-14361 Pharma Potent PARP1 inhibitor 0
Iniparib (BSI-201) Pharma PARP1 inhibitor,intravenously adminsitered 0

(4) Additional Compounds for PARP10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9
4-HQN
491-36-1
DR 2313
284028-90-6
PJ 34 hydrochloride
344458-15-7
genes like me logo Genes that share compounds with PARP10: view

Transcripts for PARP10 Gene

Unigene Clusters for PARP10 Gene

Poly (ADP-ribose) polymerase family, member 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PARP10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^
SP1: - - - -
SP2:
SP3:
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9:
SP10: - - - - - - - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

ExUns: 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for PARP10 Gene

GeneLoc Exon Structure for
PARP10
ECgene alternative splicing isoforms for
PARP10

Expression for PARP10 Gene

mRNA expression in normal human tissues for PARP10 Gene

Protein differential expression in normal tissues from HIPED for PARP10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.1) and CD8 Tcells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP10 Gene



SOURCE GeneReport for Unigene cluster for PARP10 Gene Hs.348609

mRNA Expression by UniProt/SwissProt for PARP10 Gene

Q53GL7-PAR10_HUMAN
Tissue specificity: Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
genes like me logo Genes that share expression patterns with PARP10: view

Protein tissue co-expression partners for PARP10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PARP10 Gene

Orthologs for PARP10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARP10 35
  • 77.75 (n)
  • 71.07 (a)
PARP10 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp10 35
  • 73.85 (n)
  • 68.56 (a)
Parp10 16
Parp10 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102548778 35
  • 73.52 (n)
  • 68.02 (a)
oppossum
(Monodelphis domestica)
Mammalia PARP10 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP10 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494418 35
  • 49.29 (n)
  • 39.7 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7657 35
zebrafish
(Danio rerio)
Actinopterygii PARP10 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for PARP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP10 Gene

ENSEMBL:
Gene Tree for PARP10 (if available)
TreeFam:
Gene Tree for PARP10 (if available)

Paralogs for PARP10 Gene

Paralogs for PARP10 Gene

genes like me logo Genes that share paralogs with PARP10: view

Variants for PARP10 Gene

Sequence variations from dbSNP and Humsavar for PARP10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs13248036 -- 143,981,469(+) aggtg(A/G)tggtg intron-variant
rs13248629 -- 143,981,666(+) aggtg(A/G)tggtg intron-variant
rs13249289 -- 143,981,906(+) aggtg(A/G)tggtg intron-variant
rs13254242 -- 143,981,435(+) tggtg(A/G)tgatg intron-variant
rs13254491 -- 143,981,475(+) tggtg(A/G)tgatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP10 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
dgv7943n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv906n27 CNV Loss 19166990
nsv470249 CNV Loss 18288195
dgv7947n71 CNV Loss 21882294
dgv7948n71 CNV Loss 21882294
dgv7949n71 CNV Loss 21882294
dgv7950n71 CNV Loss 21882294
dgv7951n71 CNV Gain+Loss 21882294
nsv891787 CNV Gain+Loss 21882294
nsv515809 CNV Gain+Loss 19592680
nsv470250 CNV Gain 18288195
nsv6445 CNV Insertion 18451855
nsv891804 CNV Loss 21882294
esv2738046 CNV Deletion 23290073
esv2738047 CNV Deletion 23290073
esv2738048 CNV Deletion 23290073
esv1340913 CNV Deletion 17803354
esv2738049 CNV Deletion 23290073

Variation tolerance for PARP10 Gene

Residual Variation Intolerance Score: 79.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.29; 85.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP10 Gene

HapMap Linkage Disequilibrium report
PARP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP10 Gene

Disorders for PARP10 Gene

Relevant External Links for PARP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP10
genes like me logo Genes that share disorders with PARP10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP10 Gene

Publications for PARP10 Gene

  1. Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. (PMID: 17430191) de la Lastra C.A. … SA!nchez-Fidalgo S. (Curr. Pharm. Des. 2007) 23 67
  2. CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10). (PMID: 16455663) Chou H.Y. … Lee S.C. (J. Biol. Chem. 2006) 23 67
  3. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 67
  4. Function and regulation of the mono-ADP-ribosyltransferase ARTD10. (PMID: 24878761) Kaufmann M. … LA1scher B. (Curr. Top. Microbiol. Immunol. 2015) 67
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 67

Products for PARP10 Gene

Sources for PARP10 Gene

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