Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PARP10 Gene

Aliases for PARP10 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 10 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 10 3 4
  • ARTD10 3 4
  • Poly [ADP-Ribose] Polymerase 10 3
  • EC 2.4.2.30 4
  • PARP-10 4

External Ids for PARP10 Gene

Previous GeneCards Identifiers for PARP10 Gene

  • GC08M145123
  • GC08M145051
  • GC08M140305

Summaries for PARP10 Gene

Entrez Gene Summary for PARP10 Gene

  • Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PARP10 Gene

PARP10 (Poly(ADP-Ribose) Polymerase Family Member 10) is a Protein Coding gene. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include nucleotide binding and K63-linked polyubiquitin binding. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for PARP10 Gene

  • May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.

Tocris Summary for PARP10 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP10 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP10 Gene

Genomics for PARP10 Gene

Regulatory Elements for PARP10 Gene

Enhancers for PARP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G143968 1.7 Ensembl ENCODE dbSUPER 12 +38.5 38533 11.0 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D PLEC MAF1 WDR97 MIR661 PARP10 SPATC1 EXOSC4 ENSG00000255224 GPAA1 CYC1
GH08G143964 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +46.6 46625 3.6 PKNOX1 FOXA2 SIN3A CEBPG ZBTB7B HIC1 CTBP1 GATA3 RCOR1 HCFC1 PLEC PARP10 SPATC1 EXOSC4 ENSG00000255224 EPPK1 PUF60 C8orf82 C8orf31 EEF1D
GH08G144073 1.6 FANTOM5 Ensembl ENCODE 11.9 -61.6 -61625 1.2 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 KLF13 ZNF491 ZNF592 WDR97 ZNF251 SPATC1 CYC1 MAF1 SHARPIN PARP10 ZNF623 ZNF250 GRINA
GH08G144455 1.4 Ensembl ENCODE 12 -443.7 -443675 1.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 SIN3A ZNF2 ZNF251 ZNF623 ZNF250 ZNF34 LRRC14 ZNF517 GPAA1 VPS28 TMED10P1 ENSG00000255164
GH08G144062 1.4 FANTOM5 ENCODE dbSUPER 11.9 -50.7 -50730 2.3 ELF3 CTCF TFAP4 ZNF792 SAP130 ARID4B MAX RAD21 YY1 HIC1 WDR97 ENSG00000255224 SPATC1 CYC1 SHARPIN MAF1 PARP10 PLEC OPLAH MIR6846
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PARP10 gene promoter:

Genomic Location for PARP10 Gene

Chromosome:
8
Start:
143,977,152 bp from pter
End:
144,012,772 bp from pter
Size:
35,621 bases
Orientation:
Minus strand

Genomic View for PARP10 Gene

Genes around PARP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP10 Gene

Proteins for PARP10 Gene

  • Protein details for PARP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GL7-PAR10_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 10
    Protein Accession:
    Q53GL7
    Secondary Accessions:
    • Q8N2I0
    • Q8WV05
    • Q96CH7
    • Q96K72

    Protein attributes for PARP10 Gene

    Size:
    1025 amino acids
    Molecular mass:
    109998 Da
    Quaternary structure:
    • Interacts with MYC (PubMed:15674325). Interacts with PARP14 (PubMed:23473667).
    SequenceCaution:
    • Sequence=BAC11498.1; Type=Frameshift; Positions=965; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP10 Gene

neXtProt entry for PARP10 Gene

Post-translational modifications for PARP10 Gene

  • Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.
  • Ubiquitination at Lys426, Lys436, Lys814, posLast=916916, and Lys941
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PARP10 Gene

Domains & Families for PARP10 Gene

Gene Families for PARP10 Gene

Suggested Antigen Peptide Sequences for PARP10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP10: view

No data available for UniProtKB/Swiss-Prot for PARP10 Gene

Function for PARP10 Gene

Molecular function for PARP10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.

Enzyme Numbers (IUBMB) for PARP10 Gene

Gene Ontology (GO) - Molecular Function for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,TAS --
GO:0005515 protein binding IPI 15674325
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP10: view
genes like me logo Genes that share phenotypes with PARP10: view

Animal Models for PARP10 Gene

MGI Knock Outs for PARP10:

Animal Model Products

CRISPR Products

miRNA for PARP10 Gene

miRTarBase miRNAs that target PARP10

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP10 Gene

Localization for PARP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP10 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP10 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15674325
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA,IEA 15674325
GO:0005829 cytosol IDA,TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with PARP10: view

Pathways & Interactions for PARP10 Gene

genes like me logo Genes that share pathways with PARP10: view

Gene Ontology (GO) - Biological Process for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IMP 23575687
GO:0010629 negative regulation of gene expression IMP 23575687
GO:0010847 regulation of chromatin assembly IDA 15674325
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 23575687
GO:0033159 negative regulation of protein import into nucleus, translocation IMP 23575687
genes like me logo Genes that share ontologies with PARP10: view

No data available for SIGNOR curated interactions for PARP10 Gene

Drugs & Compounds for PARP10 Gene

(11) Drugs for PARP10 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 919,923
AG-14361 Pharma Potent PARP1 inhibitor 0
Iniparib (BSI-201) Pharma PARP1 inhibitor,intravenously adminsitered 0
INO-1001 Pharma Potent PARP inhibitor 0
ME0328 Pharma PARP inhibitor,potent and selective 0

(1) Additional Compounds for PARP10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP10 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3

(5) ApexBio Compounds for PARP10 Gene

Compound Action Cas Number
AG-14361 Potent PARP1 inhibitor 328543-09-5
Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered 160003-66-7
INO-1001 Potent PARP inhibitor 3544-24-9
ME0328 PARP inhibitor,potent and selective 1445251-22-8
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
genes like me logo Genes that share compounds with PARP10: view

Drug Products

Transcripts for PARP10 Gene

Unigene Clusters for PARP10 Gene

Poly (ADP-ribose) polymerase family, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^
SP1: - - - -
SP2:
SP3:
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9:
SP10: - - - - - - - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

ExUns: 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for PARP10 Gene

GeneLoc Exon Structure for
PARP10
ECgene alternative splicing isoforms for
PARP10

Expression for PARP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP10 Gene

Protein differential expression in normal tissues from HIPED for PARP10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.1) and CD8 Tcells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP10 Gene



Protein tissue co-expression partners for PARP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP10 Gene:

PARP10

SOURCE GeneReport for Unigene cluster for PARP10 Gene:

Hs.348609

mRNA Expression by UniProt/SwissProt for PARP10 Gene:

Q53GL7-PAR10_HUMAN
Tissue specificity: Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.

Evidence on tissue expression from TISSUES for PARP10 Gene

  • Skin(4.3)
  • Nervous system(4.3)
  • Kidney(4.2)
  • Liver(4.2)
  • Thyroid gland(4.2)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with PARP10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP10 Gene

Orthologs for PARP10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARP10 34 35
  • 77.75 (n)
mouse
(Mus musculus)
Mammalia Parp10 34 16 35
  • 73.85 (n)
rat
(Rattus norvegicus)
Mammalia LOC102548778 34
  • 73.52 (n)
oppossum
(Monodelphis domestica)
Mammalia PARP10 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP10 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494418 34
  • 49.29 (n)
zebrafish
(Danio rerio)
Actinopterygii PARP10 35
  • 22 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7657 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for PARP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP10 Gene

ENSEMBL:
Gene Tree for PARP10 (if available)
TreeFam:
Gene Tree for PARP10 (if available)

Paralogs for PARP10 Gene

Paralogs for PARP10 Gene

genes like me logo Genes that share paralogs with PARP10: view

Variants for PARP10 Gene

Sequence variations from dbSNP and Humsavar for PARP10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000881324 -- 143,979,100(+) CCCGA(A/G)TAGCT intron-variant
rs1000954880 -- 143,984,394(+) GAAAC(C/T)CCTCA nc-transcript-variant, reference, missense
rs1000974009 -- 143,978,829(+) AGGGA(A/G)GACGC intron-variant
rs1001610286 -- 143,986,771(+) AGTCA(C/T)TGCCC upstream-variant-2KB
rs1001763387 -- 143,987,022(+) CAGCT(G/T)TCTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PARP10 Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv12432n54 CNV loss 21841781
dgv12433n54 CNV gain 21841781
dgv906n27 CNV loss 19166990
esv1340913 CNV deletion 17803354
esv2738046 CNV deletion 23290073
esv2738047 CNV deletion 23290073
esv2738048 CNV deletion 23290073
esv2738049 CNV deletion 23290073
nsv1077076 CNV deletion 25765185
nsv1130887 CNV deletion 24896259
nsv1149362 CNV deletion 26484159
nsv1161815 CNV deletion 26073780
nsv470249 CNV loss 18288195
nsv470250 CNV gain 18288195
nsv472207 CNV novel sequence insertion 20440878
nsv472334 CNV novel sequence insertion 20440878
nsv475079 CNV novel sequence insertion 20440878
nsv475842 CNV novel sequence insertion 20440878
nsv476239 CNV novel sequence insertion 20440878
nsv479131 CNV novel sequence insertion 20440878
nsv479966 CNV novel sequence insertion 20440878
nsv480849 CNV novel sequence insertion 20440878
nsv481087 CNV novel sequence insertion 20440878
nsv481469 CNV novel sequence insertion 20440878
nsv515809 CNV gain+loss 19592680
nsv612906 CNV loss 21841781
nsv612907 CNV gain+loss 21841781
nsv612914 CNV loss 21841781
nsv6445 CNV insertion 18451855
nsv950015 CNV deletion 24416366

Variation tolerance for PARP10 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.29; 85.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP10 Gene

Human Gene Mutation Database (HGMD)
PARP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP10 Gene

Disorders for PARP10 Gene

Relevant External Links for PARP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP10

No disorders were found for PARP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP10 Gene

Publications for PARP10 Gene

  1. CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10). (PMID: 16455663) Chou H.Y. … Lee S.C. (J. Biol. Chem. 2006) 3 4 22 64
  2. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. (PMID: 23473667) Forst A.H. … Luscher B. (Structure 2013) 3 4 64
  3. PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. (PMID: 15674325) Yu M. … Luescher B. (Oncogene 2005) 3 4 64
  4. The PARP superfamily. (PMID: 15273990) AmAc J.C. … de Murcia G. (Bioessays 2004) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PARP10 Gene

Sources for PARP10 Gene

Content
Loading form....