Aliases for PARP1 Gene
- Poly (ADP-Ribose) Polymerase 1 2 3
- ADPRT 3 4 6
- PPOL 3 4 6
- ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase) 2 3
- ADP-Ribosyltransferase Diphtheria Toxin-Like 1 3 4
- Poly (ADP-Ribose) Polymerase Family, Member 1 2 3
- NAD(+) ADP-Ribosyltransferase 1 3 4
- Poly[ADP-Ribose] Synthase 1 3 4
- EC 18.104.22.168 4 63
- ADPRT 1 3 4
- PARP-1 3 4
External Ids for PARP1 Gene
Previous HGNC Symbols for PARP1 Gene
Previous GeneCards Identifiers for PARP1 Gene
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARP1 Gene
PARP1 (Poly (ADP-Ribose) Polymerase 1) is a Protein Coding gene. Diseases associated with PARP1 include diphtheria and hemorrhagic cystitis. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include identical protein binding and protein N-terminus binding. An important paralog of this gene is PARP3.
UniProtKB/Swiss-Prot for PARP1 Gene
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain polymers. PARP-1, one of 5 confirmed PARPs, is the most abundant and highly expressed enzyme. PARP1 detects and relocates to single strand breaks or nicks in chromosomal DNA. PARP-1 is thought to play an important role in the initiation of the DNA repair pathway, although high levels of activation are also associated with increased apoptosis in response to genotoxic stress. In addition, PARP-1 may also operate downstream of the Raf-MEK-ERK pathway through direct interaction with ERK2 in the nucleus in a mechanism DNA damage. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes, stroke and cardiovascular disease.