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PARP1 Gene

protein-coding   GIFtS: 73
GCID: GC01M226548

Poly (ADP-Ribose) Polymerase 1

(Previous names: ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase),...)
(Previous symbols: PPOL, ADPRT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly (ADP-Ribose) Polymerase 11 2     EC 2.4.2.303 8
ADPRT1 2 3 5     PARP2 5
PPOL1 2 3 5     ADPRT12
ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)1 2     ADP-Ribosyltransferase NAD(+)2
Poly (ADP-Ribose) Polymerase Family, Member 11 2     pADPRT-12
Poly[ADP-Ribose] Synthase 12 3     Poly [ADP-Ribose] Polymerase 12
ARTD12 3     poly(ADP-ribosyl)transferase2
PARP-12 3     Poly(ADP-Ribose) Polymerase2
ADP-Ribosyltransferase Diphtheria Toxin-Like 12 3     Poly(ADP-Ribose) Synthetase2
ADPRT 12 3     EC 2.4.28
NAD(+) ADP-Ribosyltransferase 12 3     

External Ids:    HGNC: 2701   Entrez Gene: 1422   Ensembl: ENSG000001437997   OMIM: 1738705   UniProtKB: P098743   

Export aliases for PARP1 gene to outside databases

Previous GC identifers: GC01M222855 GC01M224615 GC01M197065 GC01M224102


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PARP1 Gene:
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear
proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of
various important cellular processes such as differentiation, proliferation, and tumor transformation and also in
the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme
may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PARP1 Gene:
PARP1 (poly (ADP-ribose) polymerase 1) is a protein-coding gene. Diseases associated with PARP1 include diphtheria, and tetraploidy. GO annotations related to this gene include protein N-terminus binding and identical protein binding. An important paralog of this gene is PARP2.

UniProtKB/Swiss-Prot: PARP1_HUMAN, P09874
Function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a
limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification
follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation
of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the
transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a
complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to
directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for
PARP9 and DTX3L recruitement to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes
the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites

summary for PARP1 Gene:
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the
addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to
glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain
polymers. PARP-1, one of 5 confirmed PARPs, is the most abundant and highly expressed enzyme. PARP1 detects
and relocates to single strand breaks or nicks in chromosomal DNA. PARP-1 is thought to play an important
role in the initiation of the DNA repair pathway, although high levels of activation are also associated
with increased apoptosis in response to genotoxic stress. In addition, PARP-1 may also operate downstream of
the Raf-MEK-ERK pathway through direct interaction with ERK2 in the nucleus in a mechanism DNA damage. PARP
inhibitors are being developed for use in a number of pathologies including cancer, diabetes, stroke and
cardiovascular disease.

Gene Wiki entry for PARP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARP1 gene promoter:
         Sp1   AP-2alpha isoform 3   AP-1   ATF-2   AP-2alpha isoform 2   C/EBPalpha   c-Jun   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARP1 promoter sequence
   Search Chromatin IP Primers for PARP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41-q42   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q41-q42

PARP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M226548:  view genomic region     (about GC identifiers)

Start:
226,548,392 bp from pter      End:
226,595,801 bp from pter
Size:
47,410 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PARP1_HUMAN, P09874 (See protein sequence)
Recommended Name: Poly [ADP-ribose] polymerase 1  
Size: 1014 amino acids; 113084 Da
Subunit: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3.
Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL,
PARP1 and SWAP70. Interacts with TIAM2 (By similarity). Interacts (when poly-ADP-ribosylated) with CHD1L.
Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the
control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK. Interacts with RNF146. Interacts
with ZNF423. Interacts with SNAI1 (via zinc fingers); the interaction requires SNAI1 to be poly-ADP-ribosylated
and non-phosphorylated (active) by GSK3B. Interacts (when poly-ADP-ribosylated) with PARP9
Miscellaneous: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the
enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine
moiety, building up a polymer with an average chain length of 20-30 units
Selected PDB 3D structures from and Proteopedia for PARP1 (see all 27):
1UK0 (3D)        1UK1 (3D)        1WOK (3D)        2COK (3D)        2CR9 (3D)        2CS2 (3D)    
Secondary accessions: B1ANJ4 Q8IUZ9

Explore the universe of human proteins at neXtProt for PARP1: NX_P09874

Explore proteomics data for PARP1 at MOPED

Post-translational modifications: 

  • Phosphorylated by PRKDC and TXK1
  • Poly-ADP-ribosylated by PARP2. Poly-ADP-ribosylation mediates the recruitment of CHD1L to DNA damage sites1
  • S-nitrosylated, leading to inhibit transcription regulation activity (By similarity)1
  • Ubiquitination2 at Lys97, Lys108, Lys119, Lys165, Lys239, Lys269, Lys320, Lys337, Lys394, Lys400,
                                 Lys528, Lys548, Lys551, Lys564, Lys579, Lys600, Lys637
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PARP1 (P09874) (see all 37)
     MIEKLGG  YNEYIVY  YVKNTHA  KTDIKVV 


    See PARP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001609.2  
    ENSEMBL proteins: 
     ENSP00000355759   ENSP00000355757   ENSP00000355755   ENSP00000355756  
    Reactome Protein details: P09874

    PARP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for PARP1
    OriGene Purified Protein for PARP1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for PARP1
    OriGene Custom Protein Services for PARP1
    GenScript Custom Purified and Recombinant Proteins Services for PARP1
    Novus Biologicals PARP1 Proteins
    Sino Biological Recombinant Protein for PARP1
    Sino Biological Cell Lysate for PARP1
    ProSpec Recombinant Protein for PARP1
    Browse Proteins at Cloud-Clone Corp.

    PARP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARP1
    R&D Systems Antibodies for PARP1 (PARP)
    Cell Signaling Technology (CST) Antibodies for PARP1 
    OriGene Antibodies for PARP1
    OriGene Custom Antibody Services for PARP1
    Novus Biologicals PARP1 Antibodies
    Abcam antibodies for PARP1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PARP1
    LSBio Antibodies in human, mouse, rat for PARP1

    PARP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PARP1
    R&D Systems Apoptosis Detection Kits & Reagents for PARP1 (PARP)         (see all)
    GenScript Custom Assay Services for PARP1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PARP1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARP: Poly (ADP-ribose) polymerases

    Selected InterPro protein domains (see all 7):
     IPR012982 PADR1
     IPR008288 NAD_ADPRT
     IPR004102 Poly(ADP-ribose)pol_reg_dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom
     IPR001510 Znf_PARP

    Graphical View of Domain Structure for InterPro Entry P09874

    ProtoNet protein and cluster: P09874

    5 Blocks protein domains:
    IPB001357 BRCT domain
    IPB001510 Zn-finger
    IPB004102 Poly(ADP-ribose) polymerase
    IPB008893 WGR
    IPB012982 PADR1


    UniProtKB/Swiss-Prot: PARP1_HUMAN, P09874
    Similarity: Contains 1 BRCT domain
    Similarity: Contains 1 PARP alpha-helical domain
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 2 PARP-type zinc fingers


    PARP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARP1_HUMAN, P09874
    Function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a
    limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification
    follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation
    of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the
    transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a
    complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to
    directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for
    PARP9 and DTX3L recruitement to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes
    the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

         Enzyme Numbers (IUBMB): EC 2.4.2.301 2 EC 2.4.22

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003950NAD+ ADP-ribosyltransferase activity TAS--
    GO:0005515protein binding IPI11248244
    GO:0008134transcription factor binding IPI19303849
    GO:0008270zinc ion binding IEA--
         
    PARP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PARP1:
     G0/1 arrest  Increased G1 DNA content 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Parp1):
     cellular  embryogenesis  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     no phenotypic analysis  renal/urinary system  reproductive system 

    PARP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PARP1: Parp1tm1Jmdm Parp1tm1Hsmm Parp1tm1Zqw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PARP1:
    hsa-mir-1301-3p (MIRT036020), hsa-mir-375 (MIRT019791), hsa-mir-615-3p (MIRT039741), hsa-mir-125b-5p (MIRT046091), hsa-mir-339-5p (MIRT042808), hsa-mir-1225-3p (MIRT036540), hsa-mir-149-5p (MIRT045417), hsa-mir-128-3p (MIRT045879), hsa-mir-21-5p (MIRT030724), hsa-mir-193b-3p (MIRT041220), hsa-mir-484 (MIRT041920), hsa-mir-874-3p (MIRT037766), hsa-mir-93-3p (MIRT038771), hsa-mir-30b-5p (MIRT046137), hsa-mir-223-3p (MIRT052650)

    Block miRNA regulation of human, mouse, rat PARP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARP1 (see all 9):
    hsa-miR-548o hsa-miR-551b* hsa-miR-7 hsa-miR-500a hsa-miR-223 hsa-miR-1323 hsa-miR-3143 hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidPARP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PARP1
    Predesigned siRNA for gene silencing in human, mouse, rat PARP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PARP1

    Clone
    Products:
         
    OriGene clones in human, mouse for PARP1 (see all 6)
    OriGene ORF clones in mouse, rat for PARP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARP1 (NM_001618)
    Sino Biological Human cDNA Clone for PARP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PARP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PARP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PARP1_HUMAN, P09874: Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion3
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    plasma membrane2
    endosome1
    golgi apparatus1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope IDA9518481
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA19303849
    GO:0005730nucleolus IDA16107709

    PARP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARP1 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    2Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Signaling by GPCR
    Signal Transduction0.58
    5Resolution of Abasic Sites (AP sites)
    Base excision repair0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PARP1 (see all 11)
        Caspase Cascade
    Granzyme Pathway
    TRAIL Pathway
    Fas Signaling
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for PARP1
        Apoptosis and Autophagy

    3 GeneGo (Thomson Reuters) Pathways for PARP1
        NAD metabolism
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    4 BioSystems Pathways for PARP1
        FAS pathway and Stress induction of HSP regulation
    Corticotropin-releasing hormone
    Caspase cascade in apoptosis
    Notch-mediated HES/HEY network

    1 Sino Biological Pathway for PARP1
        Death Receptor Signaling

    1 Reactome Pathway for PARP1
        Downregulation of SMAD2/3:SMAD4 transcriptional activity


    2 Kegg Pathways  (Kegg details for PARP1):
        Base excision repair
    NF-kappa B signaling pathway


    PARP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARP1 (see all 11): 
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Diabetes in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cancer Drug Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PARP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARP1 (P098741, 2, 3 ENSP000003557594) via UniProtKB, MINT, STRING, and/or I2D (see all 899)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4CP628053, ENSP000003670344I2D: score=3 STRING: ENSP00000367034
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000723telomere maintenance IEA--
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair TAS17396150
    GO:0006284base-excision repair IEA--

    PARP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PARP1
    Selected ApexBio Compounds for PARP1 (see all 19)     About this table
    CompoundAction CAS #
    4-HQNInhibitor of PARP[491-36-1]
    A-966492novel and potent inhibitor of PARP1 and PARP2[934162-61-5]
    ABT-888 (Veliparib)potent inhibitor of PARP1 and PARP2[912444-00-9]
    AG-14361potent inhibitor of PARP1[328543-09-5]
    AZD2461novel PARP inhibitor[1174043-16-3]
    BMN 673potent and selective inhibitor of PARP1,PARP2[1207456-01-6]
    BYK 204165Potent and selective PARP1 inhibitor[1104546-89-5]
    BYK 49187PARP-1 and PARP-2 inhibitor[163120-31-8]
    DR 2313competitive inhibitor of PARP1 and PARP2[284028-90-6]
    EB 47potent inhibitor of PARP-1[1190332-25-2]

    Compounds for PARP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    3 HMDB Compounds for PARP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--

    Selected DrugBank Compounds for PARP1 (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide-- --target--17139284 17016423 10592235
    2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone-- --target--17139284 17016423 10592235
    3,4-Dihydro-5-Methyl-Isoquinolinone-- --target--17139284 17016423 10592235
    3-Methoxybenzamide-- --target--17139284 17016423 10592235
    Carba-Nicotinamide-Adenine-Dinucleotide-- --target--17139284 17016423 10592235
    (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium-- --target--10592235
    2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide-- --target--10592235
    5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE-- --target--10592235
    6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE-- --target--10592235
    NU1025-- 90417-38-2target--10592235

    Selected Novoseek inferred chemical compound relationships for PARP1 gene (see all 134)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 97 638 16391829 (3), 8657188 (3), 7578422 (3), 11185961 (3) (see all 99)
    3-aminobenzamide 90.1 212 19699512 (3), 17444865 (2), 11996891 (2), 17217379 (2) (see all 99)
    nad+ 85.2 289 14769338 (5), 20181594 (4), 18239155 (4), 14594650 (4) (see all 99)
    nu1025 83.2 30 11139322 (5), 20067769 (4), 9823965 (2), 19401788 (2) (see all 14)
    polyadenosine diphosphate ribose 82.1 29 18440520 (2), 12854754 (1), 14645003 (1), 15388586 (1) (see all 25)
    1,5-isoquinolinediol 80.2 26 9041562 (1), 15855340 (1), 15604259 (1), 17187679 (1) (see all 11)
    nicotinamide 76.2 93 18600553 (3), 16021911 (3), 12519385 (2), 19127863 (2) (see all 58)
    6 (5h)-phenanthridinone 75.5 14 11062748 (2), 12519385 (1), 9453543 (1), 10746948 (1) (see all 9)
    sp 600125 72.7 11 14724571 (1), 16151469 (1), 16923120 (1), 19248828 (1) (see all 8)
    4-amino-1,8-naphthalimide 66.1 11 18695944 (1), 15729291 (1), 9972795 (1), 16546970 (1) (see all 6)



    PARP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for PARP1 gene: 
    NM_001618.3  

    Unigene Cluster for PARP1:

    Poly (ADP-ribose) polymerase 1
    Hs.177766  [show with all ESTs]
    Unigene Representative Sequence: NM_001618
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366794(uc001hqd.4) ENST00000490921 ENST00000463968 ENST00000491816
    ENST00000468608 ENST00000498787 ENST00000469663 ENST00000366792 ENST00000366790
    ENST00000366791
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PARP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARP1 (see all 9):
    hsa-miR-548o hsa-miR-551b* hsa-miR-7 hsa-miR-500a hsa-miR-223 hsa-miR-1323 hsa-miR-3143 hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidPARP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PARP1
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    OriGene ORF clones in mouse, rat for PARP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PARP1 (NM_001618)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PARP1
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      QuantiTect SYBR Green Assays in human, mouse, rat PARP1
      QuantiFast Probe-based Assays in human, mouse, rat PARP1

    Additional mRNA sequence: 

    AF401218.1 AK125650.1 AK225654.1 AK303340.1 AK312339.1 BC008660.1 BC014206.2 BC018620.1 
    BC021045.1 BC037545.1 J03473.1 M17081.1 M18112.1 M32721.1 

    Selected DOTS entries (see all 30):

    DT.100031860  DT.92459767  DT.95162798  DT.319999  DT.101966196  DT.121396081  DT.100039042  DT.99930369 
    DT.95162803  DT.100769656  DT.120774472  DT.121396123  DT.95257379  DT.87078950  DT.95162805  DT.95280602 
    DT.100638345  DT.100708068  DT.100774247  DT.100807045  DT.100844538  DT.120769781  DT.121396064  DT.121396074 

    Selected AceView cDNA sequences (see all 742):

    BQ430662 BU192831 AF401218 BG655856 BQ574995 BE349151 BU687688 CA848335 
    BG120331 BQ946216 AA418746 CA868005 BI093436 BM474368 BM670536 BM722314 
    CK822010 BF513424 BU732115 BM971342 BG163336 BM474022 BQ882633 CA425412 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PARP1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
    SP1:                          -     -                                                                                         -                                 
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            
    SP4:              -           -     -                                                                                                                           
    SP5:                          -                                                                                                                                 

    ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b
    SP1:                          -                                 
    SP2:  -                       -                                 
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PARP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTCTTG
    PARP1 Expression
    About this image


    PARP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PARP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.177766
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARP1 (see all 11): 
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Diabetes in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cancer Drug Targets in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PARP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PARP1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Parp11 , 5 poly (ADP-ribose) polymerase family, member 11, 5 86.48(n)1
    92.2(a)1
      1 (84.44 cM)5
    115451  NM_007415.21  NP_031441.21 
     1805689755 
    chicken
    (Gallus gallus)
    Aves PARP11 poly (ADP-ribose) polymerase 1 75.17(n)
    79.54(a)
      396199  NM_205263.1  NP_990594.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARP16
    poly (ADP-ribose) polymerase 1
    77(a)
    1 ↔ 1
    1(251418195-251468113)
    African clawed frog
    (Xenopus laevis)
    Amphibia PARP2 NAD(+) ADP-ribosyltransferase 77.05(n)    D14667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii parp11 poly (ADP-ribose) polymerase family, member 1 69.45(n)
    72.14(a)
      560788  NM_001044942.1  NP_001038407.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Parp1 Poly-(ADP-ribose) polymerase 49.48(n)
    43.8(a)
      3355109  NM_001110982.2  NP_001104452.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pme-11 pme-1 48.15(n)
    41.13(a)
      266823  NM_058671.7  NP_491072.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PARP11 PARP1 50.21(n)
    42.25(a)
      817690  NM_179834.1  NP_850165.1 
    rice
    (Oryza sativa)
    Liliopsida Os.319002 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.35(n)    AK103479.1 


    ENSEMBL Gene Tree for PARP1 (if available)
    TreeFam Gene Tree for PARP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARP1 gene
    PARP22  PARP32  
    2 SIMAP similar genes for PARP1 using alignment to 5 protein entries:     PARP1_HUMAN (see all proteins):
    PARP2    LIG3

    PARP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PARP1
    PGOHUM00000248684


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARP1 (see all 1298)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358524
    A breast cancer sample4--see VAR_0358522 E V mis40--------
    rs1159246071,2
    C,F--226548011(+) CCTTCC/TGTAAA 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1853499171,2
    --226548065(+) TGAAAC/TGTAAA 1 -- ds50010--------
    rs763138761,2
    C,F--226548148(+) GAGCAG/AGATGA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1112640551,2
    C--226548184(+) AGCCG-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1909979071,2
    --226548274(+) GGCACA/GTTCTG 1 -- ds50010--------
    rs32191501,2
    C,F--226548313(-) CTTTGG/CGGGGA 1 -- ds50012Minor allele frequency- C:0.04NS WA 292
    rs562328401,2
    C--226548359(+) TCTGTA/GGTCAG 1 -- ds50010--------
    rs32191491,2
    C,F,H--226548417(-) TACTCG/TATTAA 1 -- ut31 ese310Minor allele frequency- T:0.02NS MN EA 978
    rs1835544841,2
    --226548447(+) AAGTAC/TATTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PARP1 (226548392 - 226595801 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PARP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832770CNV Loss17160897
    nsv527874CNV Loss19592680
    nsv832781CNV Gain17160897

    Human Gene Mutation Database (HGMD): PARP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PARP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PARP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173870    OMIM disorders: --

    Selected diseases for PARP1 (see all 190):    
    About MalaCards
    diphtheria    tetraploidy    skin squamous cell carcinoma    bladder transitional cell papilloma
    amelanotic melanoma    brain injury    alexia    congenital anomalies of kidney and urinary tract
    cardia cancer    fanconi's anemia    diabetic polyneuropathy    cervical adenocarcinoma
    oral cavity cancer    werner syndrome    ewing's family of tumors    menieres disease
    meniere's disease    cockayne syndrome    varicocele    acoustic neuroma

    16 diseases from the University of Copenhagen DISEASES database for PARP1:
    Diphtheria     Cholera     Breast cancer     Leukemia
    Cerebrovascular accident     Toxic encephalopathy     Pertussis     Diabetes mellitus
    Prostate cancer     Lymphoma     Lung cancer     Ovarian cancer
    Malignant glioma     Retinoblastoma     Diabetic neuropathy     Colorectal cancer

    PARP1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PARP1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 71 197 1837923 (3), 19934756 (3), 18221025 (3), 19362586 (3) (see all 99)
    leukemia 68.1 26 16323285 (3), 15142883 (2), 11807010 (2), 9013854 (1) (see all 21)
    tumors 63.9 238 19823047 (5), 15142883 (4), 11935214 (3), 19383921 (3) (see all 99)
    necrosis 62.2 147 10373561 (4), 10868778 (3), 19529948 (3), 11907276 (3) (see all 99)
    promyelocytic leukemia 60.2 6 15246875 (1), 2121532 (1), 15375593 (1), 11456129 (1) (see all 6)
    colon cancer 59.8 16 10100720 (4), 16809434 (2), 11494135 (1), 16157217 (1) (see all 8)
    breast cancer 56.4 77 16906222 (6), 17560163 (4), 16810332 (3), 20164690 (3) (see all 51)
    myeloid leukemia 53.6 4 19407318 (1), 15756438 (1), 12382020 (1), 17156654 (1)
    prostate cancer 52.6 11 15252149 (1), 15868402 (1), 17295209 (1), 18377872 (1) (see all 11)
    ovarian cancer 50.4 13 18837894 (2), 1904797 (1), 12520732 (1), 20124459 (1) (see all 12)

    Genetic Association Database (GAD): PARP1
    Human Genome Epidemiology (HuGE) Navigator: PARP1 (82 documents)

    Export disorders for PARP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PARP1 gene, integrated from 10 sources (see all 2592):
    (articles sorted by number of sources associating them with PARP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines. (PubMed id 20113831)1, 4, 9 Ogino H....Masutani M. (Cancer Genet. Cytogenet. 2010)
    2. Influence of PARP-1 polymorphisms in patients after traumatic brain injury. (PubMed id 19925161)1, 4, 9 Sarnaik A.A....Clark R.S. (J. Neurotrauma 2010)
    3. Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. (PubMed id 17560163)1, 4, 9 Cao W.H....Tong W.M. (Mutat. Res. 2007)
    4. PARP-1 transcriptional activity is regulated by sumoylation upon heat shock. (PubMed id 19779455)1, 2, 9 Martin N.... Dejean A. (EMBO J. 2009)
    5. Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease. (PubMed id 17362997)1, 4, 9 Infante J....Combarros O. (J. Neurol. Sci. 2007)
    6. Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. (PubMed id 20353610)1, 4, 9 Prasad P....Thelma B.K. (BMC Med. Genet. 2010)
    7. PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males. (PubMed id 20196871)1, 4, 9 Jin X.M....Choi C. (BMC Med. Genet. 2010)
    8. The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients. (PubMed id 19030862)1, 4, 9 Onaran I....KanigA1r-Sultuybek G. (Rheumatol. Int. 2009)
    9. Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population. (PubMed id 19147860)1, 4, 9 Li W.Q....You W.C. (Carcinogenesis 2009)
    10. The Ala allele at Val762Ala polymorphism in poly(ADP-ribose) polymerase-1 (PARP-1) gene is associated with a decreased risk of asthma in a Turkish population. (PubMed id 19484672)1, 4, 9 Tezcan G....Kanigur-Sultuybek G. (J Asthma 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 142 HGNC: 270 AceView: PARP1 Ensembl:ENSG00000143799 euGenes: HUgn142
    ECgene: PARP1 Kegg: 142 H-InvDB: PARP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PARP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PARP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adprt/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PARP1 gene:
    Search GeneIP for patents involving PARP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Block miRNA regulation of human, mouse, rat PARP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PARP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARP1 Predesigned siRNA for gene silencing in human, mouse, rat PARP1
     QuantiFast Probe-based Assays in human, mouse, rat PARP1 QuantiTect SYBR Green Assays in human, mouse, rat PARP1
     PCR Arrays including human, mouse, rat PARP1 Search Chromatin IP Primers for PARP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARP1  GeneGlobe Interaction Network for PARP1
     Regulatory tfbs in PARP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PARP1 GenScript cDNA clones with any tag delivered in your preferred vector for PARP1
     GenScript Custom Assay Services for PARP1 GenScript Custom overexpressing Cell Line Services for PARP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PARP1 

     Tocris compounds for PARP1
     Proteins for PARP1
     Cell Lysates for PARP1
     cDNA Clones for PARP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for PARP1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PARP1 antibodies
     PARP1 proteins
     Antibodies for PARP1
     See all of Abcam's Antibodies, Kits and Proteins for PARP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PARP1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PARP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARP1
     SwitchGear 3'UTR luciferase reporter plasmids for PARP1
     SwitchGear Promoter luciferase reporter plasmids for PARP1
     ThermoFisher Antibody for PARP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARP1
     LSBio Antibodies in human, mouse, rat for PARP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for PARP1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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