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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PARK7 Gene

protein-coding   GIFtS: 69
GCID: GC01P008014

Parkinson Protein 7

(Previous names: Parkinson disease (autosomal recessive, early onset) 7)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Parkinson Protein 71 2     DJ-12
Parkinson Disease (Autosomal Recessive, Early Onset) 71 2     Protein DJ-12
Oncogene DJ12 3     EC 3.4.-.-3
DJ12 5     Parkinson Disease Protein 73

External Ids:    HGNC: 163691   Entrez Gene: 113152   Ensembl: ENSG000001162887   OMIM: 6025335   UniProtKB: Q994973   

Export aliases for PARK7 gene to outside databases

Previous GC identifers: GC01U990455 GC01P007830 GC01P007618 GC01P007731 GC01P007956 GC01P007944 GC01P007169


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PARK7 Gene:
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of
androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for
oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this
gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the
same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PARK7 Gene: 
PARK7 (parkinson protein 7) is a protein-coding gene. Diseases associated with PARK7 include amyotrophic lateral sclerosis-parkinsonism/dementia complex 1, and park7-related parkinson disease, and among its related super-pathways are Electron Transport Chain and Synaptic vesicle cycle. GO annotations related to this gene include mRNA binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
function as a redox-sensitive chaperone

Gene Wiki entry for PARK7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PARK7 gene promoter:
         PPAR-gamma1   POU2F1   SREBP-1a   AML1a   POU2F1a   SREBP-1c   PPAR-gamma2   Pax-4a   SREBP-1b   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PARK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

PARK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P008014:  view genomic region     (about GC identifiers)

Start:
8,014,351 bp from pter      End:
8,045,565 bp from pter
Size:
31,215 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497 (See protein sequence)
Recommended Name: Protein DJ-1 precursor  
Size: 189 amino acids; 19891 Da
Subunit: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.
Interacts (via N-terminus) with OTUD7B. Interacts with BBS1, HIPK1, CLCF1 and MTERF
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Under normal conditions, located predominantly in
the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and
subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against
oxidative damage. Detected in tau inclusions in brains from neurodegenerative disease patients
6/26 PDB 3D structures from and Proteopedia for PARK7 (see all 26):
1J42 (3D)        1P5F (3D)        1PDV (3D)        1PDW (3D)        1PE0 (3D)        1Q2U (3D)    
Secondary accessions: B2R4Z1 O14805 Q6DR95 Q7LFU2

Explore the universe of human proteins at neXtProt for PARK7: NX_Q99497

Explore proteomics data for PARK7 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for
    cell-growth promoting activity and transforming activity
  • UniProtKB: Cys-106 is easily oxidized to sulfinic acid
  • UniProtKB: Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative
    stress
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99497

  • PARK7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PARK7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116849.1  NP_009193.2  

    ENSEMBL proteins: 
     ENSP00000465404   ENSP00000340278   ENSP00000418770   ENSP00000466242   ENSP00000366711  
     ENSP00000366708   ENSP00000466756  

    Human Recombinant Protein Products for PARK7: 
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    Novus Biologicals PARK7 Proteins
    Novus Biologicals PARK7 Lysates
    Sino Biological Recombinant Protein for PARK7
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PARK7
    Cloud-Clone Corp. Proteins for PARK7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11477070
    GO:0005737cytoplasm IDA12446870
    GO:0005739mitochondrion IDA18711745

    PARK7 for ontologies           About GeneDecksing



    PARK7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARK7
    R&D Systems Antibodies for PARK7 (Park7/DJ-1)
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    Abcam antibodies for PARK7
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    LSBio Antibodies in human, mouse, rat for PARK7 

    Assay Products for PARK7: 
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    GenScript Custom Assay Services for PARK7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PARK7 
    Cloud-Clone Corp. CLIAs for PARK7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PARK: Parkinson disease

    2 InterPro protein domains:
     IPR006287 DJ1
     IPR002818 ThiJ/PfpI

    Graphical View of Domain Structure for InterPro Entry Q99497

    ProtoNet protein and cluster: Q99497

    1 Blocks protein domain: IPB002818 Family of unknown function ThiJ/PfpI

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Similarity: Belongs to the peptidase C56 family


    PARK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARK7_HUMAN, Q99497
    Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
    stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
    substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
    L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
    peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
    peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
    action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
    its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
    translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
    their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
    function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
    positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
    fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
    function as a redox-sensitive chaperone
    Biophysicochemical properties: Kinetic parameters: KM=173.4 uM for casein;
    Induction: By hydrogen peroxide and UV irradiation

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA18626009
    GO:0004601peroxidase activity ISS--
    GO:0005515protein binding IPI11477070
    GO:0008233peptidase activity IDA--
    GO:0042803protein homodimerization activity IDA18711745
         
    PARK7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PARK7:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Park7):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  nervous system 

    PARK7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PARK7: Park7tm1Cai Park7tm1Tmd Park7tm1Xz Park7tm1Shn Park7tm1Dsp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PARK7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PARK7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARK7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARK7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARK7
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    SwitchGear 3'UTR luciferase reporter plasmidPARK7 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PARK7 (NM_007262)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARK7
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                         Customized lentivirus expression plasmids for stable overexpression of PARK7 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PARK7 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.61
    2Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    3TNF Signaling
    Death Receptor Signaling0.50
    4CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31
    5Parkinsons Disease Pathway
    Parkinsons Disease Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PARK7
        Parkinson's Disease Pathway

    2 Cell Signaling Technology (CST) Pathways for PARK7
        Neuroscience
    PI3K / Akt Signaling

    4 BioSystems Pathways for PARK7
        Parkinsons Disease Pathway
    Androgen receptor signaling pathway
    Synaptic Vesicle Pathway
    Alpha-synuclein signaling

    1 Sino Biological Pathway for PARK7 
        Death Receptor Signaling


    1         Kegg Pathway  (Kegg details for PARK7):
        Parkinson's disease


    PARK7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PARK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for PARK7 (Q994971, 2, 3 ENSP000003402784) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206206Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000206279Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000227046Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000231617Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    MTA2O947761, 3, ENSP000002788234EBI-1164361,EBI-1783035 I2D: score=2 STRING: ENSP00000278823
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ----
    GO:0006508proteolysis IEA--
    GO:0006914autophagy IEA--
    GO:0006950response to stress ----
    GO:0006954inflammatory response IEA--

    PARK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PARK7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PARK7

    1 DrugBank Compound for PARK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Double Oxidized Cysteine-- --target--17139284 17016423

    10/17 Novoseek inferred chemical compound relationships for PARK7 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    e 64d 76.3 9 15365989 (3), 17451229 (1), 20186336 (1), 15663963 (1)
    sulfinic acid 59.7 3 16403519 (2), 16181642 (1)
    rotenone 56 8 18377993 (3), 16439141 (2), 16854843 (2), 18930142 (1)
    6-hydroxydopamine 51.9 8 18377993 (3), 18974921 (1), 16860563 (1), 16227205 (1) (see all 5)
    dopamine 46.9 33 16978583 (4), 18974921 (4), 19703902 (3), 16227205 (2) (see all 9)
    cysteine 34.6 35 16316629 (3), 19124468 (2), 16935423 (2), 18570440 (2) (see all 13)
    h2o2 30.8 20 16935423 (2), 15081400 (2), 20046643 (2), 14652021 (1) (see all 10)
    levodopa 29.9 1 19703902 (1)
    oxygen 17.5 13 16403519 (1), 16115732 (1), 18430896 (1), 15219840 (1) (see all 12)
    pyrimidine 14.5 4 16731528 (2), 15790595 (1), 18689799 (1)

    Search CenterWatch for drugs/clinical trials and news about PARK7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PARK7 gene (2 alternative transcripts): 
    NM_001123377.1  NM_007262.4  

    Unigene Cluster for PARK7:

    Parkinson protein 7
    Hs.419640  [show with all ESTs]
    Unigene Representative Sequence: BF965121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493373 ENST00000460192 ENST00000338639(uc001aou.4 uc001aox.4 uc001aov.4)
    ENST00000493678 ENST00000377493 ENST00000465354 ENST00000377491 ENST00000377488
    ENST00000497113 ENST00000469225
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB073864.1 AF021819.1 AK130886.1 AK312000.1 BC008188.2 D61380.2 

    24/30 DOTS entries (see all 30):

    DT.100864956  DT.448826  DT.91912005  DT.100864954  DT.100864946  DT.99944190  DT.91858715  DT.100723157 
    DT.121340910  DT.95171052  DT.100864949  DT.100864951  DT.100864952  DT.95171053  DT.91717622  DT.95171037 
    DT.100864945  DT.100864955  DT.121340885  DT.121340900  DT.121340908  DT.121340933  DT.121340949  DT.91778970 

    818 AceView cDNA sequences (see top 24):

    AA908891 BE515210 BF094931 BU521162 BI826586 AL558174 BM014914 BQ953110 
    CR616157 AA664387 BX324483 AA312271 H95132 BM739800 BM985360 BI856917 
    BM825330 BG754603 W67123 AA039589 AI870594 AA602784 BM972739 CD672896 
    BQ052914 Z41594 BM756396 BM824731 BM760127 F20533 BM760169 BQ030064 
    CR623768 AA745919 BI712058 AI291271 BM738949 AA360496 AA782060 BM685534 
    BM504242 AI340293 BU194430 AI340289 BE794210 BM464399 BQ716403 BQ431243 
    AA621820 BP870566 BQ689827 AW327656 BM507294 BM565556 AA857890 BU731851 
    BI713009 BM832829 BU682926 BM466509 BM760078 CB108284 CB106548 CF128271 
    AA576779 BM740026 BM739440 BM771807 BU595800 BM771392 BU730460 BF002713 
    BM771887 BM760888 BM704825 BM784009 AI761742 AA315948 BM670136 BM759196 
    CD673038 AA535605 BM835995 BM759942 BM700123 CR618546 BQ420525 AA338326 
    BU657605 BQ028408 BF038857 BM970518 BM663446 BM771427 BQ448057 BU507463 
    BM760096 BU167723 AI174859 BQ436114 D61380 BM792160 BM760893 AV704886 
    CD047909 BE550383 BQ643180 BI085219 BG113506 BM712090 BU533141 AK091679 
    AX747125 T34178 AA315511 AA251345 AI202676 BM760109 BM750124 BM756505 
    C05103 AL556933 CB996016 CR623919 AJ709120 BM741700 CR591123 CD050392 
    AA039588 AA670002 BM910109 BM852110 BQ437995 F26009 BM707721 F31941 
    BM454284 BF037742 BM914964 BM709072 BU733245 BM853389 T30497 BM757918 
    BI830621 BM771936 AI042422 BM908816 CB146358 BU159556 AA773602 AI340291 
    BE253104 AW248378 AI564730 BX324481 BU589696 BM504459 CB108934 BM832175 
    BG530596 BM696948 BQ436065 BU660583 BM476270 BG503232 BE256566 CD520814 
    BM450448 BU659430 BE514925 BM745717 BC008188 AV714584 AW406425 BF758569 
    BG715880 BU600022 BG027271 BE409907 AI479785 BU596513 BM754733 AL556806 
    BM797575 BG610692 BM978273 BM760787 BE408488 BX400386 CB997439 BM453371 
    CB112661 AA969401 AI205219 AA927139 BG121158 BF979202 CF130154 BP345841 
    BG705972 D61243 BM764367 BE734171 BF680243 AA101116 BE873735 BG027551 
    BG771654 BE729401 AI750074 BE044936 BM770984 BG397729 CB990976 BM758413 
    BG617951 CB113686 AB073864 BX324480 CB114202 AA359577 BG542982 BI860650 
    CB107062 BM781506 CD247911 BU596224 BI669109 BV174154 AI023091 AI299226 
    BU186540 BM020637 BM833037 BI552690 BI858857 BM271944 BE612711 BU933538 
    BE786592 BG756205 CB994570 BQ212397 BU660943 AA969322 BI092098 BU603047 
    BM759978 CR619796 C05602 CA413329 BF968416 BE280484 BM721574 AA305373 
    BM043362 BG527698 BM740234 W16665 BM313054 BU656177 BU660800 BQ648712 
    CF128206 BM973909 C03009 AI147833 BF792275 BI770788 AI089754 BU849447 
    Z45982 BG336215 W42604 CA867705 CA309297 T35472 T35586 BF244130 
    BF794080 BM313333 BU688129 BU178542 BF663649 BP870464 BM739429 BM771443 
    BQ640074 BM547712 BM834633 AF021819 BM475943 AV734385 CF128522 BG183715 
    BF036842 R78197 BU189074 BM841559 BP342698 BE884370 BG190934 CB147694 
    BM747812 BI599015 BU945447 BM806720 AI660534 BM691038 BI259158 BM554785 
    AA770265 CB994113 BI862167 AA569602 AV701044 BF979943 BG773967 CD369322 
    BM473249 BM974673 F03427 BM264575 BG778103 BM785713 BM677199 BM997585 
    BU603303 BG216416 BG574615 BM750026 BE714792 F22363 T30771 AI051570 
    BU932550 BU527611 BU660931 BG564822 BP373347 D80701 CD367391 AW327341 
    BM752044 BE542498 BG473010 BF340167 BG505648 NM_007262 BM739007 T61971 
    BG401600 BM759779 CB110305 BQ212897 CB108094 BM767095 BG757388 BG424977 
    W68839 BE257972 BI457686 BG618364 BM739418 BU687752 BG616612 BQ421876 
    BQ887259 BU193062 BU630080 CB991918 BI858850 BE622126 BE386433 BF984854 
    BI549623 CB044395 BU148556 BM770994 CF126312 BM738685 CB986032 AJ572206 
    BE747390 BI752414 AA334247 BU508809 BF663568 BG036516 BG547400 BM825036 
    AI608749 BU941957 BG113413 BM754747 CB135857 BU655916 BM469775 BM761128 
    AA360248 CB305962 BE904866 CD384909 BG563173 BE882274 BM838051 BF670759 
    BM549447 BI468196 BX444623 BU942782 CD104643 AK130886 CD050202 BG616740 
    AA649975 N78638 BF033416 BG423342 F32879 BQ230427 BG770239 BG501575 
    CA868472 BG750611 AI342421 AI936972 BF979558 BX324482 AV745458 F36909 
    AJ346332 CF130579 BP369862 BM751890 AA188297 BU657225 AA339292 BG341878 
    AI302083 CB108324 BQ337743 AL523595 CA411878 BM841748 AA082613 CB997655 
    BU752245 AI741250 BQ928255 CA848524 CF597299 BU660390 AI673204 AA670451 
    BE729243 BG194659 AA430079 BG616245 BI492331 CB111342 BE740170 CB139182 
    BQ430301 BM476996 BU657451 D80458 BU658230 CA777472 BE562354 AI247773 
    D61064 BG200274 AA148486 AV736486 T30413 D80951 CB994921 BF959953 
    AA310134 AI767860 BI194256 AA219044 BM748951 AW651676 BG393962 CD707231 
    AI190063 AA055453 F07139 CD110216 CF527958 BI602006 AA329174 BG202862 
    BE567765 AV745502 N77240 BG179920 BE782528 BM743588 CB321705 AI052100 
    BF305543 AL597221 BF796819 BM691397 CD703195 AW673137 CD707706 H41623 
    AI031586 BM833215 BF184620 CB958261 BQ953241 BF678748 N81066 BF978875 
    BU659448 AI498521 BF681354 BG109435 AI243399 BG219128 C03334 BU656249 
    BQ953086 BF244004 BG496051 BG716033 BU165447 BG182169 D53132 BM840620 
    BP428853 BG480113 BF304756 AA574416 CD623973 BU683903 T30680 BI257537 
    BG500728 D79762 BI457646 BM990268 BG567095 BQ694844 AA055454 BF003013 
    AV685152 BU661538 CB956553 AV759648 BM840613 BU933082 AL597220 BG207529 
    AA716183 AA569496 BU664329 BI549393 CA437228 BG564854 W69749 CB130655 
    AA502953 BP430704 BG622377 T35410 BF697565 AI830287 AW955128 CB995456 
    BG941195 BG108953 N56354 BE958231 BF681557 AW021299 W46765 BG401990 
    D61761 AA587727 BM747356 CD703086 BG505547 CD698540 AV711323 BQ376649 
    AI349300 AA129779 BI085865 BE896092 CA453781 BM991452 AV745522 BF094973 
    CD696942 AV746418 AV691510 BM797379 CD689853 D79337 BG230501 AL558173 
    BE928219 CD706643 CB991322 T29930 AJ346410 BM739882 BE827551 AV722182 
    D53083 AW806383 BF126090 AV695518 AV745893 AI983345 CD701374 CK001102 
    CD691001 AA228859 F30887 BG256228 F32888 BQ934466 BG498240 D52382 
    BF700328 AV744394 AV763748 BF382373 AV716113 AV701247 AW607029 AV701087 
    AV745904 BU074761 AI034421 BI468195 AI034314 CD298828 BX351075 AI034225 
    AA733210 BF476745 CD641373 AW380211 BG484602 AW380197 AA216242 AA228370 
    BF216838 BE928232 BG200275 BU074477 BP349001 BF242793 F27456 W42607 
    T61908 BM465181 BG029568 CB107597 CD692502 AV753003 BU589551 BI860373 
    BE177604 AV757884 D81438 BF907442 CD106479 R51981 H42326 BF571111 
    BG213865 BX106037 T35662 BG422859 C17909 BE870483 AV753888 H24532 
    BE047815 D61300 BM045884 AV745614 AW793435 BE833667 BQ347810 D81267 
    BE440017 CD623974 C04479 AA251440 AA376344 D53402 BF758566 BE622939 
    BF675687 BF907444 AU099598 BF341610 AJ574003 AA481957 W31890 BF170373 
    BU566510 AV736392 W07496 T35587 BU595868 CD520724 BE961136 AW206383 
    CA777735 BF798908 BG757311 AW904199 AI149327 BF837367 AV753975 BQ377065 
    BG219621 AI189013 BG112406 BF086088 BQ230393 BG210698 BG202303 AA308838 
    BG471144 BM987677 AV701341 BU600587 BU944919 BU953513 CA842038 BM503757 
    BM787501 CD702892 BE568546 CD110428 BM476682 AA219196 D81357 CD522098 
    BF907424 AW806434 AW800369 CD521754 BQ435677 AV707572 CD247024 BM754224 
    BF841538 AA186809 AW170613 D58737 AV700974 AA019415 AV722608 BF675780 
    BF094970 AL582600 D81330 BI827423 BM509906 BM907005 BE258993 CB961441 
    AV692049 AA947522 W69856 BF965368 BF907427 D60929 BF693327 AI707820 
    BU179010 BF306402 BF336957 H38029 BF094947 AW810585 BQ428860 BF907437 
    BQ317990 BE767842 BE970959 BX394683 H42923 BF175519 AW806398 BF745980 
    BG185293 BF751458 AW967133 CA841746 BE899270 AA092956 AI206790 BG026601 
    BQ307988 CD251159 BE826121 BF907431 R11782 BU596849 BQ312553 AW674240 
    BU168051 BF335901 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PARK7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -     -     -     -                                         -     -                                 
    SP2:                          -     -     -                                         -     -                                 
    SP3:                                                                                -     -                                 
    SP4:                    -     -     -     -                 -     -                 -     -                                 
    SP5:                                      -                                         -     -                                 


    ECgene alternative splicing isoforms for PARK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARK7 expression in normal human tissues (normalized intensities)      PARK7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAGGTTT
    PARK7 Expression
    About this image


    PARK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain

    See PARK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PARK7

    SOURCE GeneReport for Unigene cluster: Hs.419640

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at
    slightly lower levels in placenta and brain. Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and
    spermatozoa

        SABiosciences Expression via Pathway-Focused PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PARK7
    OriGene qSTAR qPCR primer pairs in human, mouse for PARK7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PARK7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARK7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARK7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PARK7 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Park71 , 5 Parkinson disease (autosomal recessive, early onset) more1, 5 84.3(n)1
    91.53(a)1
      4 (81.52 cM)5
    573201  NM_020569.31  NP_065594.21 
     1508971335 
    chicken
    (Gallus gallus)
    Aves PARK71 Parkinson disease (autosomal recessive, early onset) more 79.37(n)
    89.95(a)
      395277  NM_204585.1  NP_989916.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARK76
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL344178.1(17994-24787)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114132 Xenopus laevis SP22 mRNA, complete cds 77.13(n)    AF394958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.155302 Transcribed sequence with moderate similarity to protein more 74.28(n)    BM317196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DJ-1alpha1 CG6646-PA 54.8(n)
    57.06(a)
      36543  NM_137072.1  NP_610916.1 
    worm
    (Caenorhabditis elegans)
    Secernentea djr-1.11 Protein DJR-1.1 57.3(n)
    54.05(a)
      173416  NM_061295.5  NP_493696.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02178001 hypothetical protein 47.99(n)
    39.56(a)
      4324581  NM_001048942.1  NP_001042407.2 


    ENSEMBL Gene Tree for PARK7 (if available)
    TreeFam Gene Tree for PARK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PARK7 gene

    PARK7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PARK7
    PGOHUM00000239770 PGOHUM00000236716


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/593 SNPs in PARK7 are shown (see all 593)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0204934
    Parkinson disease 7 (PARK7)4--see VAR_0204932 E D mis40--------
    VAR_0204924
    Parkinson disease 7 (PARK7)4--see VAR_0204922 M I mis40--------
    VAR_0204954
    Parkinson disease 7 (PARK7)4--see VAR_0204952 A T mis40--------
    rs743153521,2,4
    C,FParkinson disease 7 (PARK7)4 pathogenic18062522(+) AAAAGA/CCGGCC 4 D A mis11Minor allele frequency- C:0.00NA 4552
    rs289381721,2,4
    CParkinson disease 7 (PARK7)4 pathogenic18062573(+) TGCGCC/TTGCAA 4 P L mis10--------
    rs743153511,2
    Cpathogenic18040457(+) GTCATA/GAGGCG 4 I M mis10--------
    rs743153531,2
    Cpathogenic18043019(+) AAAGAC/GGTTTG 4 D E mis10--------
    VAR_0204974
    ----see VAR_0204972 G S mis40--------
    VAR_0204994
    ----see VAR_0204992 A S mis40--------
    VAR_0348014
    ----see VAR_0348012 E K mis40--------

    HapMap Linkage Disequilibrium report for PARK7 (8014351 - 8045565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PARK7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1521CNV Insertion18451855
    nsv871360CNV Gain21882294


    Human Gene Mutation Database (HGMD): PARK7

    Locus Specific Mutation Databases (LSDB): PARK7
    1 SABiosciences Cancer Mutation PCR Assay for PARK7:
    Cosmic IdAA Change
    98000118
    SeqTarget long-range PCR primers for resequencing PARK7
    DNA2.0 Custom Variant and Variant Library Synthesis for PARK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602533   
    OMIM disorders: 606324  
    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
  • Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor,
    postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40
    years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of
    amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/66 diseases for PARK7 (see all 66):    About MalaCards
    amyotrophic lateral sclerosis-parkinsonism/dementia complex 1    park7-related parkinson disease    parkinson disease 7, autosomal recessive early-onset    parkinson's disease
    spinocerebellar ataxia type 17    tauopathy    inclusion body myositis    clear cell renal cell carcinoma
    laryngeal carcinoma    myositis    multiple system atrophy    brachydactyly
    hepatitis b virus infection    corneal dystrophy    dementia    pick's disease
    tremor    laryngitis    was-related disorders    spinocerebellar ataxia

    1 disease from the University of Copenhagen DISEASES database for PARK7:
    Parkinson's disease

    PARK7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/20 Novoseek inferred disease relationships for PARK7 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 89.2 181 20157014 (6), 14662519 (5), 15219840 (4), 14707326 (3) (see all 99)
    autosomal recessive parkinsonism 87.5 12 14638971 (3), 19429112 (2), 17914725 (1), 19297401 (1) (see all 7)
    parkinsonism 85.4 87 19429112 (5), 15565491 (2), 19124468 (2), 15542239 (2) (see all 47)
    parkinsonism juvenile autosomal recessive 81 10 14652021 (1), 14745011 (1), 17268184 (1), 19243613 (1) (see all 8)
    parkinson disease, autosomal dominant 76.4 2 15717024 (1)
    neurodegenerative diseases 74.9 18 19686841 (2), 14705119 (2), 17719794 (2), 18930142 (1) (see all 12)
    neurodegeneration 65.1 11 14712351 (2), 19023331 (1), 16115732 (1), 16439141 (1) (see all 9)
    movement disorders 64 1 18704525 (1)
    tauopathies 57.9 8 14991385 (2), 15935068 (1), 17085780 (1), 14705119 (1)
    lewy body disease 38.6 1 14625045 (1)

    GeneTests: PARK7
    GeneReviews: PARK7
    Genetic Association Database (GAD): PARK7
    Human Genome Epidemiology (HuGE) Navigator: PARK7 (24 documents)

    Export disorders for PARK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARK7 gene, integrated from 9 sources (see all 404):
    (articles sorted by number of sources associating them with PARK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. (PubMed id 14872018)1, 2, 4, 9 Hedrich K.... Klein C. (2004)
    2. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. (PubMed id 9070310)1, 2, 3, 9 Nagakubo D.... Ariga H. (1997)
    3. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. (PubMed id 18711745)1, 2, 9 Junn E....Mouradian M.M. (2009)
    4. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. (PubMed id 14662519)1, 2, 9 Bandopadhyay R.... Lees A.J. (2004)
    5. DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. (PubMed id 16390825)1, 2, 9 Sekito A....Ariga H. (2006)
    6. The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. (PubMed id 12855764)1, 2, 9 Wilson M.A.... Petsko G.A. (2003)
    7. A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo- oligomerization. (PubMed id 14713311)1, 2, 9 Moore D.J.... Dawson V.L. (2003)
    8. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. (PubMed id 12914946)1, 2, 9 Huai Q.... Ke H. (2003)
    9. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. (PubMed id 11223268)1, 2, 9 Taira T.... Ariga H. (2001)
    10. Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism. (PubMed id 19429112)1, 4, 9 Tomiyama H....Hattori N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11315 HGNC: 16369 AceView: PARK7 Ensembl:ENSG00000116288 euGenes: HUgn11315
    ECgene: PARK7 Kegg: 11315 H-InvDB: PARK7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PARK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PARK7 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PARK7
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=P&genename=PARK7+%40+DJ-1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PARK7 gene:
    Search GeneIP for patents involving PARK7

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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