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PARK7 Gene

protein-coding   GIFtS: 71
GCID: GC01P008014

Parkinson Protein 7

(Previous names: Parkinson disease (autosomal recessive, early onset) 7)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Parkinson Protein 71 2     HEL-S-67p2
Parkinson Disease (Autosomal Recessive, Early Onset) 71 2     Epididymis Secretory Sperm Binding Protein Li 67p2
Oncogene DJ12 3     Protein DJ-12
DJ12 5     EC 3.4.-.-3
DJ-12     Parkinson Disease Protein 73

External Ids:    HGNC: 163691   Entrez Gene: 113152   Ensembl: ENSG000001162887   OMIM: 6025335   UniProtKB: Q994973   

Export aliases for PARK7 gene to outside databases

Previous GC identifers: GC01U990455 GC01P007830 GC01P007618 GC01P007731 GC01P007956 GC01P007944 GC01P007169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PARK7 Gene:
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of
androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for
oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this
gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the
same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PARK7 Gene:
PARK7 (parkinson protein 7) is a protein-coding gene. Diseases associated with PARK7 include park7-related parkinson disease, and parkinson disease 7, autosomal recessive early-onset. GO annotations related to this gene include peptidase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and
neuronal cells

Gene Wiki entry for PARK7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARK7 gene promoter:
         PPAR-gamma1   POU2F1   SREBP-1a   AML1a   POU2F1a   SREBP-1c   PPAR-gamma2   Pax-4a   SREBP-1b   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARK7 promoter sequence
   Search Chromatin IP Primers for PARK7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

PARK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P008014:  view genomic region     (about GC identifiers)

Start:
8,014,351 bp from pter      End:
8,045,565 bp from pter
Size:
31,215 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497 (See protein sequence)
Recommended Name: Protein DJ-1 precursor  
Size: 189 amino acids; 19891 Da
Subunit: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.
Interacts (via N-terminus) with OTUD7B. Interacts with BBS1, HIPK1, CLCF1 and MTERF
Selected PDB 3D structures from and Proteopedia for PARK7 (see all 27):
1J42 (3D)        1P5F (3D)        1PDV (3D)        1PDW (3D)        1PE0 (3D)        1Q2U (3D)    
Secondary accessions: B2R4Z1 O14805 Q6DR95 Q7LFU2

Explore the universe of human proteins at neXtProt for PARK7: NX_Q99497

Explore proteomics data for PARK7 at MOPED

Post-translational modifications: 

  • Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for
    cell-growth promoting activity and transforming activity1
  • Cys-106 is easily oxidized to sulfinic acid1
  • Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative
    stress1
  • Ubiquitination2 at Lys41, Lys99, Lys148
  • Modification sites at PhosphoSitePlus

  • See PARK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116849.1  NP_009193.2  

    ENSEMBL proteins: 
     ENSP00000465404   ENSP00000340278   ENSP00000418770   ENSP00000466242   ENSP00000366711  
     ENSP00000366708   ENSP00000466756  

    PARK7 Human Recombinant Protein Products:

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    Novus Biologicals PARK7 Proteins
    Novus Biologicals PARK7 Lysates
    Sino Biological Recombinant Protein for PARK7
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PARK7
    Cloud-Clone Corp. Proteins for PARK7

    PARK7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARK7
    R&D Systems Antibodies for PARK7 (Park7/DJ-1)
    Cell Signaling Technology (CST) Antibodies for PARK7  (DJ-1)
    OriGene Antibodies for PARK7
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    PARK7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PARK7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PARK7
    Cloud-Clone Corp. CLIAs for PARK7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    PARK: Parkinson disease

    2 InterPro protein domains:
     IPR006287 DJ1
     IPR002818 ThiJ/PfpI

    Graphical View of Domain Structure for InterPro Entry Q99497

    ProtoNet protein and cluster: Q99497

    1 Blocks protein domain: IPB002818 Family of unknown function ThiJ/PfpI

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Similarity: Belongs to the peptidase C56 family


    PARK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARK7_HUMAN, Q99497
    Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
    stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
    substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
    L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
    peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
    peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
    action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
    its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
    translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
    their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
    function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
    positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
    fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
    function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and
    neuronal cells
    Biophysicochemical properties: Kinetic parameters: KM=173.4 uM for casein;
    Induction: By hydrogen peroxide and UV irradiation

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA18626009
    GO:0004601peroxidase activity ISS--
    GO:0005515protein binding IPI11477070
    GO:0008233peptidase activity IDA--
    GO:0042803protein homodimerization activity IDA18711745
         
    PARK7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PARK7:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Park7):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  nervous system 

    PARK7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PARK7: Park7tm1Cai Park7tm1Tmd Park7tm1Xz Park7tm1Shn Park7tm1Dsp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARK7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARK7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARK7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARK7

    miRNA
    Products:
        
    miRTarBase miRNAs that target PARK7:
    hsa-mir-92b-3p (MIRT040717), hsa-mir-222-3p (MIRT046823), hsa-mir-92a-3p (MIRT049137), hsa-mir-26b-5p (MIRT029955)

    Block miRNA regulation of human, mouse, rat PARK7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PARK7
    SwitchGear 3'UTR luciferase reporter plasmidPARK7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PARK7

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PARK7 (NM_007262)
    Sino Biological Human cDNA Clone for PARK7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARK7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PARK7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PARK7_HUMAN, Q99497: Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Note=Under
    normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and
    mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress
    and exerts an increased cytoprotective effect against oxidative damage. Detected in tau inclusions in brains from
    neurodegenerative disease patients. Membrane raft localization in astrocytes and neuronal cells requires
    palmitoylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11477070
    GO:0005737cytoplasm IDA12446870
    GO:0005739mitochondrion IMP--
    GO:0005829cytosol IMP--
    GO:0005886plasma membrane IEA--

    PARK7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARK7 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    2Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    3TNF Signaling
    Death Receptor Signaling0.50
    4CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31
    5PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PARK7
        Parkinson's Disease Pathway

    2 Cell Signaling Technology (CST) Pathways for PARK7
        Neuroscience
    PI3K / Akt Signaling

    4 BioSystems Pathways for PARK7
        Parkinsons Disease Pathway
    Androgen receptor signaling pathway
    Synaptic Vesicle Pathway
    Alpha-synuclein signaling

    1 Sino Biological Pathway for PARK7
        Death Receptor Signaling


    1 Kegg Pathway  (Kegg details for PARK7):
        Parkinson's disease


    PARK7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PARK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARK7 (Q994971, 2, 3 ENSP000003402784) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206206Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000206279Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000227046Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000231617Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    MTA2O947761, 3, ENSP000002788234EBI-1164361,EBI-1783035 I2D: score=2 STRING: ENSP00000278823
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ----
    GO:0006508proteolysis ----
    GO:0006914autophagy IEA--
    GO:0006954inflammatory response IEA--
    GO:0007005mitochondrion organization ISS--

    PARK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PARK7

    1 DrugBank Compound for PARK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Double Oxidized Cysteine-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for PARK7 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    e 64d 76.3 9 15365989 (3), 17451229 (1), 20186336 (1), 15663963 (1)
    sulfinic acid 59.7 3 16403519 (2), 16181642 (1)
    rotenone 56 8 18377993 (3), 16439141 (2), 16854843 (2), 18930142 (1)
    6-hydroxydopamine 51.9 8 18377993 (3), 18974921 (1), 16860563 (1), 16227205 (1) (see all 5)
    dopamine 46.9 33 16978583 (4), 18974921 (4), 19703902 (3), 16227205 (2) (see all 9)
    cysteine 34.6 35 16316629 (3), 19124468 (2), 16935423 (2), 18570440 (2) (see all 13)
    h2o2 30.8 20 16935423 (2), 15081400 (2), 20046643 (2), 14652021 (1) (see all 10)
    levodopa 29.9 1 19703902 (1)
    oxygen 17.5 13 16403519 (1), 16115732 (1), 18430896 (1), 15219840 (1) (see all 12)
    pyrimidine 14.5 4 16731528 (2), 15790595 (1), 18689799 (1)



    PARK7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for PARK7 gene (2 alternative transcripts): 
    NM_001123377.1  NM_007262.4  

    Unigene Cluster for PARK7:

    Parkinson protein 7
    Hs.419640  [show with all ESTs]
    Unigene Representative Sequence: BF965121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493373 ENST00000460192 ENST00000338639(uc001aou.4 uc001aox.4 uc001aov.4)
    ENST00000493678 ENST00000377493 ENST00000465354 ENST00000377491 ENST00000377488
    ENST00000497113 ENST00000469225
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PARK7
      QuantiFast Probe-based Assays in human, mouse, rat PARK7

    Additional mRNA sequence: 

    AB073864.1 AF021819.1 AK130886.1 AK312000.1 BC008188.2 D61380.2 

    Selected DOTS entries (see all 30):

    DT.100864956  DT.448826  DT.91912005  DT.100864954  DT.100864946  DT.99944190  DT.91858715  DT.100723157 
    DT.121340910  DT.95171052  DT.100864949  DT.100864951  DT.100864952  DT.95171053  DT.91717622  DT.95171037 
    DT.100864945  DT.100864955  DT.121340885  DT.121340900  DT.121340908  DT.121340933  DT.121340949  DT.91778970 

    Selected AceView cDNA sequences (see all 818):

    AA251345 AI202676 BM760109 BM750124 BM756505 C05103 AL556933 CB996016 
    CR623919 AJ709120 BM741700 CR591123 CD050392 AI761742 BM759196 CD672896 
    BM704825 BM824731 BQ028408 BM760888 BM760169 AA602784 BU657605 AA039588 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PARK7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -     -     -     -                                         -     -                                 
    SP2:                          -     -     -                                         -     -                                 
    SP3:                                                                                -     -                                 
    SP4:                    -     -     -     -                 -     -                 -     -                                 
    SP5:                                      -                                         -     -                                 


    ECgene alternative splicing isoforms for PARK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAGGTTT
    PARK7 Expression
    About this image


    PARK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PARK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARK7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419640

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at
    slightly lower levels in placenta and brain. Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and
    spermatozoa

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PARK7
    OriGene qSTAR qPCR primer pairs in human, mouse for PARK7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARK7
    QuantiTect SYBR Green Assays in human, mouse, rat PARK7
    QuantiFast Probe-based Assays in human, mouse, rat PARK7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PARK7 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Park71 , 5 Parkinson disease (autosomal recessive, early onset) more1, 5 84.3(n)1
    91.53(a)1
      4 (81.52 cM)5
    573201  NM_020569.31  NP_065594.21 
     1508971335 
    chicken
    (Gallus gallus)
    Aves PARK71 Parkinson disease (autosomal recessive, early onset) more 79.37(n)
    89.95(a)
      395277  NM_204585.1  NP_989916.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARK76
    parkinson protein 7
    86(a)
    1 ↔ 1
    GL344178.1(17994-24787)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114132 Xenopus laevis SP22 mRNA, complete cds 77.13(n)    AF394958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.155302 Transcribed sequence with moderate similarity to protein more 74.28(n)    BM317196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DJ-1alpha1 DJ-1alpha 54.68(n)
    56.74(a)
      36543  NM_137072.1  NP_610916.1 
    worm
    (Caenorhabditis elegans)
    Secernentea djr-1.11 djr-1.1 57.3(n)
    54.05(a)
      173416  NM_061295.6  NP_493696.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G532801 AT1G53280 50(n)
    44.32(a)
      841762  NM_104206.3  NP_564626.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g05312001 Os06g0531200 48.4(n)
    41.81(a)
      4341205  NM_001064318.1  NP_001057783.2 


    ENSEMBL Gene Tree for PARK7 (if available)
    TreeFam Gene Tree for PARK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARK7 gene

    PARK7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PARK7
    PGOHUM00000239770 PGOHUM00000236716


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARK7 (see all 593)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743153521,2,,4
    C,FParkinson disease 7 (PARK7)4 pathogenic18062522(+) AAAAGA/CCGGCC 4 D A mis11Minor allele frequency- C:0.00NA 4552
    rs289381721,2,,4
    CParkinson disease 7 (PARK7)4 pathogenic18062573(+) TGCGCC/TTGCAA 4 P L mis10--------
    VAR_0204934
    Parkinson disease 7 (PARK7)4--see VAR_0204932 E D mis40--------
    VAR_0204924
    Parkinson disease 7 (PARK7)4--see VAR_0204922 M I mis40--------
    VAR_0204954
    Parkinson disease 7 (PARK7)4--see VAR_0204952 A T mis40--------
    rs743153511,2
    Cpathogenic18040457(+) GTCATA/GAGGCG 4 I M mis10--------
    rs743153531,2
    Cpathogenic18043019(+) AAAGAC/GGTTTG 4 D E mis10--------
    rs355406561,2
    C--8029645(+) CAAAC-/TTTTTTT 2 -- int10--------
    rs1859284181,2
    --8037254(+) CCACTA/GTGGAA 2 -- us2k10--------
    rs1906380831,2
    --8037549(+) CTCGAA/GAGACT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARK7 (8014351 - 8045565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PARK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1521CNV Insertion18451855
    nsv871360CNV Gain21882294

    Human Gene Mutation Database (HGMD): PARK7
    Locus Specific Mutation Databases (LSDB): PARK7

    1 Site Specific Mutation Identification with PCR Assay for PARK7:
    Cosmic IdAA Change
    98000118
    SeqTarget long-range PCR primers for resequencing PARK7
    DNA2.0 Custom Variant and Variant Library Synthesis for PARK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602533   
    OMIM disorders: 606324  
    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
  • Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor,
    postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40
    years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of
    amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for PARK7 (see all 74):    
    About MalaCards
    park7-related parkinson disease    parkinson disease 7, autosomal recessive early-onset    amyotrophic lateral sclerosis-parkinsonism/dementia complex 1    amyotrophic lateral sclerosis-parkinsonism/dementia complex
    parkinson disease 10    spinocerebellar ataxia type 17    tauopathy    parkinson disease 1
    parkinson's disease    inclusion body myositis    laryngeal carcinoma    corneal dystrophy
    laryngitis    multiple system atrophy    myositis    clear cell renal cell carcinoma
    brachydactyly    ependymoma    hepatitis b virus infection    pick's disease

    1 disease from the University of Copenhagen DISEASES database for PARK7:
    Parkinson's disease

    PARK7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PARK7 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 89.2 181 20157014 (6), 14662519 (5), 15219840 (4), 14707326 (3) (see all 99)
    autosomal recessive parkinsonism 87.5 12 14638971 (3), 19429112 (2), 17914725 (1), 19297401 (1) (see all 7)
    parkinsonism 85.4 87 19429112 (5), 15565491 (2), 19124468 (2), 15542239 (2) (see all 47)
    parkinsonism juvenile autosomal recessive 81 10 14652021 (1), 14745011 (1), 17268184 (1), 19243613 (1) (see all 8)
    parkinson disease, autosomal dominant 76.4 2 15717024 (1)
    neurodegenerative diseases 74.9 18 19686841 (2), 14705119 (2), 17719794 (2), 18930142 (1) (see all 12)
    neurodegeneration 65.1 11 14712351 (2), 19023331 (1), 16115732 (1), 16439141 (1) (see all 9)
    movement disorders 64 1 18704525 (1)
    tauopathies 57.9 8 14991385 (2), 15935068 (1), 17085780 (1), 14705119 (1)
    lewy body disease 38.6 1 14625045 (1)

    GeneTests: PARK7
    GeneReviews: PARK7
    Genetic Association Database (GAD): PARK7
    Human Genome Epidemiology (HuGE) Navigator: PARK7 (24 documents)

    Export disorders for PARK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PARK7 gene, integrated from 10 sources (see all 417) (see top 10):
    (articles sorted by number of sources associating them with PARK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. (PubMed id 14872018)1, 2, 4, 9 Hedrich K.... Klein C. (Neurology 2004)
    2. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. (PubMed id 9070310)1, 2, 3, 9 Nagakubo D.... Ariga H. (Biochem. Biophys. Res. Commun. 1997)
    3. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. (PubMed id 18711745)1, 2, 9 Junn E.... Mouradian M.M. (J. Neurosci. Res. 2009)
    4. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. (PubMed id 14662519)1, 2, 9 Bandopadhyay R.... Lees A.J. (Brain 2004)
    5. DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. (PubMed id 16390825)1, 2, 9 Sekito A....Ariga H. (Free Radic. Res. 2006)
    6. The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. (PubMed id 12855764)1, 2, 9 Wilson M.A.... Petsko G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo- oligomerization. (PubMed id 14713311)1, 2, 9 Moore D.J.... Dawson V.L. (J. Neurochem. 2003)
    8. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. (PubMed id 12914946)1, 2, 9 Huai Q.... Ke H. (FEBS Lett. 2003)
    9. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. (PubMed id 11223268)1, 2, 9 Taira T.... Ariga H. (Gene 2001)
    10. Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism. (PubMed id 19429112)1, 4, 9 Tomiyama H....Hattori N. (Neurosci. Lett. 2009)
    11. The role of pathogenic DJ-1 mutations in Parkinson's disease. (PubMed id 12953260)1, 2, 9 Abou-Sleiman P.M.... Wood N.W. (Ann. Neurol. 2003)
    12. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. (PubMed id 11477070)1, 2, 9 Takahashi K....Ariga H. (J. Biol. Chem. 2001)
    13. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. (PubMed id 20186336)1, 2, 9 Krebiehl G.... Kruger R. (PLoS ONE 2010)
    14. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. (PubMed id 18626009)1, 2, 9 van der Brug M.P.... Cookson M.R. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    15. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. (PubMed id 17015834)1, 2, 9 Clements C.M.... Ting J.P. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    16. Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity. (PubMed id 15308309)1, 4, 9 Tan E.K....Wong M.C. (Neurosci. Lett. 2004)
    17. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. (PubMed id 15181200)1, 2, 9 Canet-Aviles R.M.... Cookson M.R. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    18. Detection of Parkin (PARK2) and DJ1 (PARK7) mutations in early-onset Parkinson disease: Parkin mutation frequency depends on ethnic origin of patients. (PubMed id 15108293)1, 4, 9 Djarmati A....Kostic V. (Hum. Mutat. 2004)
    19. Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism. (PubMed id 15372597)1, 4, 9 Lockhart P.J....Farrer M.J. (Mov. Disord. 2004)
    20. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. (PubMed id 17846173)1, 2, 9 Olzmann J.A....Chin L.S. (J. Cell Biol. 2007)
    21. Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. (PubMed id 14607841)1, 2, 9 Goerner K.... Kahle P.J. (J. Biol. Chem. 2004)
    22. Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. (PubMed id 12761214)1, 2, 9 Tao X. and Tong L. (J. Biol. Chem. 2003)
    23. DJ-1 is a Parkinson's disease susceptibility gene in southern Italy. (PubMed id 19968671)1, 4, 9 De Marco E.V....Quattrone A. (Clin. Genet. 2010)
    24. Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease. (PubMed id 18973254)1, 4, 9 Macedo M.G....Heutink P. (Mov. Disord. 2009)
    25. PINK1, Parkin, and DJ-1 mutations in Italian patients with early- onset parkinsonism. (PubMed id 15970950)1, 4, 9 Klein C.... Pramstaller P.P. (Eur. J. Hum. Genet. 2005)
    26. Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). (PubMed id 15365989)1, 2, 9 Hering R....Riess O. (Hum. Mutat. 2004)
    27. [Association of the DJ-1 gene polymorphism with sporadic Parkinson's disease in Sichuan province of China]. (PubMed id 18841573)1, 4, 9 Chen W....Jiang Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    28. Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease. (PubMed id 18704525)1, 4, 9 Choi J.M....Kim Y.J. (Neurogenetics 2008)
    29. A deletion in DJ-1 and the risk of dementia--a population-based survey. (PubMed id 15542239)1, 4, 9 Arias VA!squez A....van Duijn C.M. (Neurosci. Lett. 2004)
    30. Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations. (PubMed id 15254937)1, 2, 9 Clark L.N....Marder K. (Mov. Disord. 2004)
    31. A limited role for DJ1 in Parkinson disease susceptibility. (PubMed id 15304593)1, 4, 9 Maraganore D.M....Farrer M.J. (Neurology 2004)
    32. DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia. (PubMed id 14705119)1, 2, 9 Rizzu P.... Heutink P. (Ann. Neurol. 2004)
    33. Mutations in the DJ-1 gene associated with autosomal recessive early- onset Parkinsonism. (PubMed id 12446870)1, 2, 9 Bonifati V.... Heutink P. (Science 2003)
    34. L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. (PubMed id 12851414)1, 2, 9 Miller D.W.... Cookson M.R. (J. Biol. Chem. 2003)
    35. Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population. (PubMed id 19405094)1, 4, 9 Nuytemans K....Theuns J. (Hum. Mutat. 2009)
    36. Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism. (PubMed id 18722801)1, 4, 9 Tarantino P....Quattrone A. (amp 2009)
    37. Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia. (PubMed id 18486522)1, 4, 9 Mellick G.D....Hattori N. (amp 2009)
    38. DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex. (PubMed id 16240358)1, 2, 9 Annesi G....Quattrone A. (Ann. Neurol. 2005)
    39. Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease. (PubMed id 14625045)1, 4, 9 Morris C.M....Singleton A.B. (Neurosci. Lett. 2003)
    40. Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD. (PubMed id 14557580)1, 4, 9 Eerola J....Singleton A.B. (Neurology 2003)
    41. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    42. DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. (PubMed id 21097510)1, 2 McNally R.S.... Ting J.P. (J. Biol. Chem. 2011)
    43. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    44. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    45. Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism. (PubMed id 20146068)1, 4 Guo J.F....Tang B.S. (J. Neurol. 2010)
    46. Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. (PubMed id 20304780)1, 2 Chen J.... Chin L.S. (Hum. Mol. Genet. 2010)
    47. Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? (PubMed id 19224617)1, 4 Sutherland G.T....Mellick G.D. (Mov. Disord. 2009)
    48. Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. (PubMed id 15976810)1, 2 Shinbo Y.... Ariga H. (Cell Death Differ. 2006)
    49. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    50. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    51. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    52. DJ-1 has a role in antioxidative stress to prevent cell death. (PubMed id 14749723)1, 2 Taira T....Ariga H. (EMBO Rep. 2004)
    53. The R98Q variation in DJ-1 represents a rare polymorphism. (PubMed id 14705128)1, 2 Hedrich K....Klein C. (Ann. Neurol. 2004)
    54. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha- synuclein aggregate formation. (PubMed id 15502874)1, 2 Shendelman S.... Abeliovich A. (PLoS Biol. 2004)
    55. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    56. The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. (PubMed id 12796482)1, 2 Honbou K....Inagaki F. (J. Biol. Chem. 2003)
    57. Immunocytochemical localization of DJ-1 in human male reproductive tissue. (PubMed id 14579415)1, 2 Yoshida K.... Iwamoto T. (Mol. Reprod. Dev. 2003)
    58. Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. (PubMed id 12939276)1, 2 Lee S.-J.... Cha S.-S. (J. Biol. Chem. 2003)
    59. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. (PubMed id 12612053)1, 2 Niki T.... Ariga H. (Mol. Cancer Res. 2003)
    60. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. (PubMed id 11462174)1, 3 van Duijn C.M....Heutink P. (Am. J. Hum. Genet. 2001)
    61. Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. (PubMed id 19885556)1, 9 Kim Y.C....Ariga H. (Int. J. Oncol. 2009)
    62. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. (PubMed id 15944198)1, 9 Zhang L....Dawson V.L. (Hum. Mol. Genet. 2005)
    63. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. (PubMed id 16227205)1, 9 Zhou W. and Freed C.R. (J. Biol. Chem. 2005)
    64. DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age. (PubMed id 18647263)1, 9 Mullett S.J....Hinkle D.A. (Neuropathology 2009)
    65. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. (PubMed id 15525661)1, 9 Moore D.J....Dawson V.L. (Hum. Mol. Genet. 2005)
    66. DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. (PubMed id 16731528)1, 9 Zhong N....Xu J. (J. Biol. Chem. 2006)
    67. Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. (PubMed id 17120294)1, 9 Olzmann J.A....Chin L.S. (J. Comp. Neurol. 2007)
    68. Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis. (PubMed id 17034344)1, 9 Lev N....Offen D. (amp 2006)
    69. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. (PubMed id 19703902)1, 9 Ishikawa S....Iguchi-Ariga S.M. (J. Biol. Chem. 2009)
    70. DJ-1 protects against dopamine toxicity. (PubMed id 18974921)1, 9 Lev N....Offen D. (J Neural Transm 2009)
    71. Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells. (PubMed id 18430896)1, 9 Zhang H.Y....Du Z.X. (Endocr. Relat. Cancer 2008)
    72. Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation. (PubMed id 18689799)1, 9 Zhong N. and Xu J. (Hum. Mol. Genet. 2008)
    73. DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. (PubMed id 19064576)1, 9 Yuen H.F....Chan K.W. (amp 2008)
    74. DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. (PubMed id 17487420)1, 9 Koide-Yoshida S....Ariga H. (Int. J. Mol. Med. 2007)
    75. DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents. (PubMed id 17599367)1, 9 Galter D....Olson L. (amp 2007)
    76. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. (PubMed id 16517609)1, 9 Choi J....Li L. (J. Biol. Chem. 2006)
    77. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. (PubMed id 16403519)1, 9 Zhou W....Fink A.L. (J. Mol. Biol. 2006)
    78. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. (PubMed id 15935068)1, 9 Meulener M.C....Giasson B.I. (J. Neurochem. 2005)
    79. Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress. (PubMed id 20127688)1, 9 Opsahl J.A....Fladmark K.E. (Proteomics 2010)
    80. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. (PubMed id 19680261)1, 9 Giaime E....Alves da Costa C. (Cell Death Differ. 2010)
    81. DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. (PubMed id 19686841)1, 9 Kahle P.J....Gasser T. (amp 2009)
    82. Proteomic analysis of oxidative stress-responsive proteins in human pneumocytes: insight into the regulation of DJ-1 expression. (PubMed id 18817430)1, 9 Duan X....Merali S. (J. Proteome Res. 2008)
    83. Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma. (PubMed id 17949781)1, 9 Davidson B....Reich R. (Hum. Pathol. 2008)
    84. Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease. (PubMed id 17451229)1, 9 Hulleman J.D....Rochet J.C. (Biochemistry 2007)
    85. Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. (PubMed id 14665635)1, 9 Olzmann J.A....Chin L.S. (J. Biol. Chem. 2004)
    86. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. (PubMed id 14652021)1, 9 Yokota T....Mizusawa H. (Biochem. Biophys. Res. Commun. 2003)
    87. Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene. (PubMed id 19825160)1, 9 Keyser R.J....Bardien S. (BMC Med. Genet. 2009)
    88. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. (PubMed id 18042550)1, 9 Fan J....Wang G. (J. Biol. Chem. 2008)
    89. DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70. (PubMed id 18382667)1, 9 Batelli S....Forloni G. (PLoS ONE 2008)
    90. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. (PubMed id 15790595)1, 9 Xu J....Yankner B.A. (Hum. Mol. Genet. 2005)
    91. DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. (PubMed id 19144925)1, 9 Vasseur S....Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    92. Differential DJ-1 gene expression in Parkinson's disease. (PubMed id 19716892)1, 9 Kumaran R....Bandopadhyay R. (Neurobiol. Dis. 2009)
    93. Expression and role of DJ-1 in leukemia. (PubMed id 18722352)1, 9 Liu H....Wang J. (Biochem. Biophys. Res. Commun. 2008)
    94. DJ-1: a newcomer in Parkinson's disease pathology. (PubMed id 18045143)1, 9 da Costa C.A. (Curr. Mol. Med. 2007)
    95. Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. (PubMed id 15219840)1, 9 Takahashi-Niki K....Ariga H. (Biochem. Biophys. Res. Commun. 2004)
    96. Prognostic significance of nuclear DJ-1 expression in astrocytoma. (PubMed id 20150646)1, 9 Miyajima Y....Fujii K. (Anticancer Res. 2010)
    97. DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. (PubMed id 20213747)1, 9 Mo J.S....Park H.S. (J. Cell. Biochem. 2010)
    98. BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity. (PubMed id 20156966)1, 9 Deeg S....Kermer P. (J. Cell Biol. 2010)
    99. Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. (PubMed id 19124468)1, 9 Blackinton J....Wilson M.A. (J. Biol. Chem. 2009)
    100. The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma. (PubMed id 19384955)1, 9 Sitaram R.T....Roos G. (Int. J. Cancer 2009)
    101. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. (PubMed id 19229105)1, 9 Xiong H....Zhang Z. (J. Clin. Invest. 2009)
    102. Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. (PubMed id 18706098)1, 9 Tian M....Han J.X. (BMC Cancer 2008)
    103. Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism. (PubMed id 18785233)1, 9 Guo J.F....Tang B.S. (Mov. Disord. 2008)
    104. DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. (PubMed id 17510388)1, 9 Tillman J.E....Kasper S. (Cancer Res. 2007)
    105. Association of PINK1 and DJ-1 confers digenic inheritance of early- onset Parkinson's disease. (PubMed id 16632486)1, 9 Tang B.... Zhang Z. (Hum. Mol. Genet. 2006)
    106. Role of DJ-1 in Parkinson's disease. (PubMed id 17085780)1, 9 Lev N....Offen D. (J. Mol. Neurosci. 2006)
    107. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. (PubMed id 15983381)1, 9 Junn E....Mouradian M.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    108. DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. (PubMed id 15703819)1, 9 Shinbo Y....Ariga H. (Int. J. Oncol. 2005)
    109. DJ-1, a novel regulator of the tumor suppressor PTEN. (PubMed id 15766664)1, 9 Kim R.H....Mak T.W. (Cancer Cell 2005)
    110. Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. (PubMed id 18922803)1, 9 Cha S.S....Kang S.O. (J. Biol. Chem. 2008)
    111. Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. (PubMed id 16316629)1, 9 Ito G....Iwatsubo T. (Biochem. Biophys. Res. Commun. 2006)
    112. Screening for DJ-1 mutations in early onset autosomal recessive parkinsonism. (PubMed id 14638971)1, 9 IbA!A+ez P....Brice A. (Neurology 2003)
    113. Genotype-phenotype correlates in Taiwanese patients with early-onset recessive Parkinsonism. (PubMed id 19006224)1, 9 Lee M.J....Wu R.M. (Mov. Disord. 2009)
    114. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. (PubMed id 19692353)1, 9 Venderova K....Park D.S. (Hum. Mol. Genet. 2009)
    115. Cysteine pKa depression by a protonated glutamic acid in human DJ-1. (PubMed id 18570440)1, 9 Witt A.C....Wilson M.A. (Biochemistry 2008)
    116. Structural effects of Parkinson's disease linked DJ-1 mutations. (PubMed id 18436956)1, 9 Malgieri G. and Eliezer D. (Protein Sci. 2008)
    117. On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study. (PubMed id 17504761)1, 9 Herrera F.E....Carloni P. (J. Biol. Chem. 2007)
    118. The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation. (PubMed id 20406884)1, 9 Xu X.M....ller S.G. (J. Cell. Sci. 2010)
    119. Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations. (PubMed id 19023331)1, 9 Zucchelli S....Gustincich S. (Cell Death Differ. 2009)
    120. Silencing DJ-1 reveals its contribution in paraquat-induced autophagy. (PubMed id 19425177)1, 9 GonzA!lez-Polo R....Fuentes J.M. (J. Neurochem. 2009)
    121. The E163K DJ-1 mutant shows specific antioxidant deficiency. (PubMed id 18822273)1, 9 Ramsey C.P. and Giasson B.I. (Brain Res. 2008)
    122. LRRK2 gene in Parkinson disease: mutation analysis and case control association study. (PubMed id 16157901)1, 9 Paisan-Ruiz C....Rogaeva E. (Neurology 2005)
    123. Genetics of Parkinson disease. (PubMed id 15717024)1, 9 Pankratz N. and Foroud T. (NeuroRx 2004)
    124. Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. (PubMed id 14712351)1, 9 Bonifati V....Heutink P. (J. Mol. Med. 2004)
    125. DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function. (PubMed id 14985393)1, 9 Lockhart P.J....Farrer M.J. (J. Med. Genet. 2004)
    126. DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism. (PubMed id 14598065)1, 9 Bonifati V....Heutink P. (Neurol. Sci. 2003)
    127. A clinical-genetic study of Parkinson's disease in a genetically isolated community. (PubMed id 14504966)4, 9 Dekker M.C....van Duijn C.M. (J. Neurol. 2003)
    128. Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7. (PubMed id 12548343)1, 9 Bonifati V....Heutink P. (Neurol. Sci. 2002)
    129. Incidence of mutations in the PARK2, PINK1, PARK7 genes in Polish early-onset Parkinson disease patients. (PubMed id 23986421)1 Koziorowski D....Friedman A. (Neurol. Neurochir. Pol. 2013)
    130. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    131. Expression of DJ-1 proteins in placentas from women with severe preeclampsia. (PubMed id 23347603)1 Kwon H.S....Park S.H. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2013)
    132. Expression of DJ-1 in endometrial cancer: close correlation with clinicopathological features and apoptosis. (PubMed id 23727824)1 Shu K....Mei T. (Int. J. Gynecol. Cancer 2013)
    133. DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. (PubMed id 23847046)2 Kim K.S.... Park S.M. (Hum. Mol. Genet. 2013)
    134. Altered expression of DJ-1 and PINK1 in sporadic ALS and in the SOD1(G93A) ALS mouse model. (PubMed id 24128678)1 Knippenberg S....Petri S. (J. Neuropathol. Exp. Neurol. 2013)
    135. Identification of the recognition sequence and target proteins for DJ-1 protease. (PubMed id 23831022)1 Mitsugi H....Ariga H. (FEBS Lett. 2013)
    136. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    137. Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. (PubMed id 23792957)1 BjAPrkblom B....ller S.G. (J. Biol. Chem. 2013)
    138. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. (PubMed id 23015639)1 Klawitter J....Seres T. (Cardiovasc. Res. 2013)
    139. DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. (PubMed id 23743200)1 Yasuda T....Iguchi-Ariga S.M. (Biochem. Biophys. Res. Commun. 2013)
    140. Peroxiredoxins and their expression in ependymomas. (PubMed id 23076395)1 Haapasalo T....Soini Y. (J. Clin. Pathol. 2013)
    141. DJ-1 regulates mast cell activation and IgE-mediated allergic responses. (PubMed id 23182168)1 Kim d.o. .K....Choi W.S. (J. Allergy Clin. Immunol. 2013)
    142. Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner. (PubMed id 23149933)1 Kato I....Ariga H. (Mol. Cell. Biol. 2013)
    143. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    144. DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE). (PubMed id 23844142)1 Shadrach K.G....Bonilha V.L. (PLoS ONE 2013)
    145. Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO. (PubMed id 23593018)1 Hwang S....Cho K.S. (PLoS Genet. 2013)
    146. The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering. (PubMed id 23418303)1 Ottolini D....Brini M. (Hum. Mol. Genet. 2013)
    147. ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1. (PubMed id 23447676)1 Duplan E....Alves da Costa C. (J. Cell. Sci. 2013)
    148. Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo. (PubMed id 23530187)1 Billia F....Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    149. DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients. (PubMed id 23592371)1 Kawate T....Kohno N. (Breast Cancer Res. Treat. 2013)
    150. DJ-1 upregulates tyrosine hydroxylase gene expression by activating its transcriptional factor Nurr1 via the ERK1/2 pathway. (PubMed id 22024154)1 Lu L....Yang H. (amp 2012)
    151. Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. (PubMed id 22428580)1 Wang X....Zhu X. (J. Neurochem. 2012)
    152. Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer. (PubMed id 21943684)1 Merikallio H....Soini Y. (Hum. Pathol. 2012)
    153. Genetic bases and phenotypes of autosomal recessive Parkinson disease in a Turkish population. (PubMed id 22233331)1 Lohmann E....Emre M. (Eur. J. Neurol. 2012)
    154. Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation. (PubMed id 22571429)1 Chen C.Y. (amp 2012)
    155. Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. (PubMed id 23151319)1 Zhu X.L....Wen W.P. (amp 2012)
    156. Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. (PubMed id 22666465)1 Yamaguchi S....Ariga H. (PLoS ONE 2012)
    157. Biochemical premotor biomarkers for Parkinson's disease. (PubMed id 22508282)1 Mollenhauer B. and Zhang J. (Mov. Disord. 2012)
    158. Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome. (PubMed id 22173095)1 Alvarez-Castelao B....CastaA+o J.G. (Biochim. Biophys. Acta 2012)
    159. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    160. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    161. DJ-1 may contribute to metastasis of non-small cell lung cancer. (PubMed id 21670963)1 Bai J....Fu S. (Mol. Biol. Rep. 2012)
    162. Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells. (PubMed id 22554508)1 Ishikawa S....Iguchi-Ariga S.M. (Biochem. Biophys. Res. Commun. 2012)
    163. Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. (PubMed id 22511790)1 Haque M.E....Park D.S. (J. Biol. Chem. 2012)
    164. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    165. Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6. (PubMed id 22532838)1 Vilotti S....Zucchelli S. (PLoS ONE 2012)
    166. The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. (PubMed id 22555455)1 Robert G....Auberger P. (Cell Death Differ. 2012)
    167. DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer. (PubMed id 22526154)1 Chen Y....Wu Y. (J. Cancer Res. Clin. Oncol. 2012)
    168. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. (PubMed id 22892098)1 Ren H....Wang G. (Mol Neurodegener 2012)
    169. Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1. (PubMed id 22515803)1 Lin J....Wilson M.A. (Biochemistry 2012)
    170. Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease. (PubMed id 22445250)1 Yonova-Doing E....Bonifati V. (amp 2012)
    171. DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. (PubMed id 22492997)1 Im J.Y....Mouradian M.M. (Hum. Mol. Genet. 2012)
    172. YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome. (PubMed id 22157000)1 Le H.T....Richarme G. (J. Biol. Chem. 2012)
    173. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats. (PubMed id 22664331)1 Sun S.Y....Pu X.P. (Brain Res. Bull. 2012)
    174. YajL, the prokaryotic homolog of the Parkinsonism-associated protein DJ-1, protects cells against protein sulfenylation. (PubMed id 22321799)1 Gautier V....Richarme G. (J. Mol. Biol. 2012)
    175. DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. (PubMed id 23250426)1 Kim J.M....Suh P.G. (Nat Commun 2012)
    176. Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas. (PubMed id 22968650)1 Shimwell N.J....Johnson P.J. (Br. J. Cancer 2012)
    177. Uncovering suitable reference proteins for expression studies in human adipose tissue with relevance to obesity. (PubMed id 22272336)1 PAcrez-PAcrez R....Peral B. (PLoS ONE 2012)
    178. DJ-1 variants in Indian Parkinson's disease patients. (PubMed id 22960331)1 Sadhukhan T....Ray J. (Dis. Markers 2012)
    179. Human DJ-1 and its homologs are novel glyoxalases. (PubMed id 22523093)1 Lee J.Y....Park C. (Hum. Mol. Genet. 2012)
    180. DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. (PubMed id 22223849)1 He X....Yuan Y. (Carcinogenesis 2012)
    181. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. (PubMed id 21785459)1 Fu K....Wang G. (Oncogene 2012)
    182. Comparative secretome analyses using a hollow fiber culture system with label-free quantitative proteomics indicates the influence of PARK7 on cell proliferation and migration/invasion in lung adenocarcinoma. (PubMed id 22985211)1 Chang Y.H....Liao P.C. (J. Proteome Res. 2012)
    183. High levels of DJ-1 protein in nipple fluid of patients with breast cancer. (PubMed id 22404125)1 Oda M....Matsubara O. (Cancer Sci. 2012)
    184. Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy. (PubMed id 22836768)1 Bitar M.S....Jurkunas U.V. (amp 2012)
    185. Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. (PubMed id 22956510)1 Kilarski L.L....Morris H.R. (Mov. Disord. 2012)
    186. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    187. DJ-1 associates with synaptic membranes. (PubMed id 21645620)1 Usami Y....Hattori N. (Neurobiol. Dis. 2011)
    188. Multiple coregulatory control of tyrosine hydroxylase gene transcription. (PubMed id 21368136)1 Reddy S.D....Kumar R. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    189. DJ-1 regulation of mitochondrial function and autophagy through oxidative stress. (PubMed id 21317550)1 McCoy M.K. and Cookson M.R. (Autophagy 2011)
    190. DJ-1-Mediated protective effect of protocatechuic aldehyde against oxidative stress in SH-SY5Y cells. (PubMed id 21160133)1 Gao J.W....Ariga H. (J. Pharmacol. Sci. 2011)
    191. DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal growth factor receptor amplification. (PubMed id 20497343)1 Hinkle D.A....Hamilton R.L. (Neuropathology 2011)
    192. Significance and relationship between DJ-1 gene and surviving gene expression in laryngeal carcinoma. (PubMed id 21556124)1 Shen Z....Ding H. (Eur J Histochem 2011)
    193. Identification of an artificial peptide motif that binds and stabilizes reduced human DJ-1. (PubMed id 21893204)1 Premkumar L....Riedl S.J. (J. Struct. Biol. 2011)
    194. Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. (PubMed id 22132160)1 Miyama A....Noguchi N. (PLoS ONE 2011)
    195. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    196. Down-regulation of DJ-1 protein in the ejaculated spermatozoa from Chinese asthenozoospermia patients. (PubMed id 21575935)1 An C.N....Pu X.P. (Fertil. Steril. 2011)
    197. The role of DJ-1 in the pathogenesis of endometriosis. (PubMed id 21445310)1 Rai P. and Shivaji S. (PLoS ONE 2011)
    198. DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. (PubMed id 21645326)1 Wang Z....Chen S. (Mol Neurodegener 2011)
    199. Growth inhibitory effects of DJ-1-small interfering RNA on laryngeal carcinoma Hep-2 cells. (PubMed id 20300974)1 Shen Z....Guo J. (Med. Oncol. 2011)
    200. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    201. PRKN, DJ-1, and PINK1 screening identifies novel splice site mutation in PRKN and two novel DJ-1 mutations. (PubMed id 21322020)1 Ghazavi F....Elahi E. (Mov. Disord. 2011)
    202. Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90. (PubMed id 21819105)1 Knobbe C.B....Schmitt-Ulms G. (J. Proteome Res. 2011)
    203. [Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients]. (PubMed id 22066264)1 Lisitskaia K.V....Shishkin S.S. (Biomed Khim 2011)
    204. High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy. (PubMed id 21426932)1 Das F....Choudhury G.G. (Cell. Signal. 2011)
    205. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. (PubMed id 20940149)1 Thomas K.J....Cookson M.R. (Hum. Mol. Genet. 2011)
    206. Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. (PubMed id 21852238)1 Ren H....Wang G. (J. Biol. Chem. 2011)
    207. Evaluating intra-genetic variants of DJ-1 among Parkinson's disease patients of eastern India. (PubMed id 21535932)1 Sanyal J....Raghavendra Rao V. (Neurol. Res. 2011)
    208. DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection. (PubMed id 21796667)1 Wang Z....Ding J. (Ann. Neurol. 2011)
    209. TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains. (PubMed id 20634198)1 Zucchelli S....Gustincich S. (Hum. Mol. Genet. 2010)
    210. Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease. (PubMed id 20736773)1 Zhang H.J....Cheung A.N. (Int. J. Gynecol. Pathol. 2010)
    211. Inhibition of mitochondrial fusion by I+-synuclein is rescued by PINK1, Parkin and DJ-1. (PubMed id 20842103)1 Kamp F....Haass C. (EMBO J. 2010)
    212. DJ-1 as a modulator of autophagy: an hypothesis. (PubMed id 20730377)1 GonzA!lez-Polo R.A....Fuentes J.M. (ScientificWorldJournal 2010)
    213. DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells. (PubMed id 20510502)1 Ren H....Wang G. (Cancer Lett. 2010)
    214. [DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis]. (PubMed id 21055329)1 Zhu X.L....Wang X.R. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010)
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    364. Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease. (PubMed id 17521740)9 Sun F....Kanthasamy A.G. (amp 2007)
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    366. A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis. (PubMed id 17914725)9 Valkovic P....Gasser T. (Mov. Disord. 2007)
    367. Are Parkinson disease patients protected from some but not all cancers? (PubMed id 17699801)9 Inzelberg R. and Jankovic J. (Neurology 2007)
    368. Genetics of Parkinson's disease and parkinsonism. (PubMed id 17563249)9 Douglas M.R....Nicholl D.J. (Expert Rev Neurother 2007)
    369. Mitochondria and neurodegeneration. (PubMed id 18074639)9 Beal M.F. (Novartis Found. Symp. 2007)
    370. The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease. (PubMed id 17352347)9 Cho J.W....Jeon B.S. (Can J Neurol Sci 2007)
    371. Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease. (PubMed id 17415511)9 Schweitzer K.J....Berg D. (J. Neurol. 2007)
    372. Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stability. (PubMed id 16652386)9 PitkAonen-Arsiola T....Kasper S. (Prostate 2006)
    373. Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor. (PubMed id 16356647)9 Jeong H....Seol W. (Neurosci. Lett. 2006)
    374. The genetics of Parkinson disease: Implications for neurological care. (PubMed id 16932540)9 Klein C. and Schlossmacher M.G. (Nat Clin Pract Neurol 2006)
    375. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. (PubMed id 16860563)9 Inden M....Ariga H. (Neurobiol. Dis. 2006)
    376. Understanding the molecular causes of Parkinson's disease. (PubMed id 17027339)9 Wood-Kaczmar A....Wood N.W. (Trends Mol Med 2006)
    377. Cloning, expression, and purification of the general stress protein YhbO from Escherichia coli. (PubMed id 16380269)9 Abdallah J....Richarme G. (Protein Expr. Purif. 2006)
    378. Recessive Parkinson's disease. (PubMed id 16615060)9 Kubo S....Mizuno Y. (Mov. Disord. 2006)
    379. Progress in familial Parkinson's disease. (PubMed id 17017529)9 Mizuno Y....Li Y. (J. Neural Transm. Suppl. 2006)
    380. Parkin: a multifaceted ubiquitin ligase. (PubMed id 17052189)9 Moore D.J. (Biochem. Soc. Trans. 2006)
    381. Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa. (PubMed id 16401616)9 Ibanez P.... Brice A. (Brain 2006)
    382. Parkinsonism genes: culprits and clues. (PubMed id 16836655)9 Abeliovich A. and Flint Beal M. (J. Neurochem. 2006)
    383. Parkin and defective ubiquitination in Parkinson's disease. (PubMed id 17017531)9 Dawson T.M. (J. Neural Transm. Suppl. 2006)
    384. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. (PubMed id 16472774)9 Goswami A....Jana N.R. (Biochem. Biophys. Res. Commun. 2006)
    385. Genetics of Parkinson's disease. (PubMed id 16026116)9 Morris H.R. (Ann. Med. 2005)
    386. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. (PubMed id 16139213)9 Meulener M....Bonini N.M. (Curr. Biol. 2005)
    387. Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells. (PubMed id 16115732)9 Nishinaga H....Ariga H. (Neurosci. Lett. 2005)
    388. Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease. (PubMed id 15790536)9 Jin J....Zhang J. (Brain Res. Mol. Brain Res. 2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11315 HGNC: 16369 AceView: PARK7 Ensembl:ENSG00000116288 euGenes: HUgn11315
    ECgene: PARK7 Kegg: 11315 H-InvDB: PARK7

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PARK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PARK7 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PARK7[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=P&genename=PARK7+%40+DJ-1

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