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PARK7 Gene

protein-coding   GIFtS: 71
GCID: GC01P008014

Parkinson Protein 7

(Previous names: Parkinson disease (autosomal recessive, early onset) 7)
  See PARK7-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Parkinson Protein 71 2     HEL-S-67p2
Parkinson Disease (Autosomal Recessive, Early Onset) 71 2     Epididymis Secretory Sperm Binding Protein Li 67p2
Oncogene DJ12 3     Protein DJ-12
DJ12 5     EC 3.4.-.-3
DJ-12     Parkinson Disease Protein 73

External Ids:    HGNC: 163691   Entrez Gene: 113152   Ensembl: ENSG000001162887   OMIM: 6025335   UniProtKB: Q994973   

Export aliases for PARK7 gene to outside databases

Previous GC identifiers: GC01U990455 GC01P007830 GC01P007618 GC01P007731 GC01P007956 GC01P007944 GC01P007169

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PARK7 Gene:
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of
androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for
oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this
gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the
same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PARK7 Gene:
PARK7 (parkinson protein 7) is a protein-coding gene. Diseases associated with PARK7 include park7-related parkinson disease, and parkinson disease 7, autosomal recessive early-onset. GO annotations related to this gene include peptidase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and
neuronal cells

Gene Wiki entry for PARK7 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARK7 gene promoter:
         PPAR-gamma1   POU2F1   SREBP-1a   AML1a   POU2F1a   SREBP-1c   PPAR-gamma2   Pax-4a   SREBP-1b   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARK7 promoter sequence
   Search Chromatin IP Primers for PARK7

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARK7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

PARK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P008014:  view genomic region     (about GC identifiers)

8,014,351 bp from pter      End:
8,045,565 bp from pter
31,215 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497 (See protein sequence)
Recommended Name: Protein DJ-1 precursor  
Size: 189 amino acids; 19891 Da
Subunit: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.
Interacts (via N-terminus) with OTUD7B. Interacts with BBS1, HIPK1, CLCF1 and MTERF
Selected PDB 3D structures from and Proteopedia for PARK7 (see all 27):
1J42 (3D)        1P5F (3D)        1PDV (3D)        1PDW (3D)        1PE0 (3D)        1Q2U (3D)    
Secondary accessions: B2R4Z1 O14805 Q6DR95 Q7LFU2

Explore the universe of human proteins at neXtProt for PARK7: NX_Q99497

Explore proteomics data for PARK7 at MOPED

Post-translational modifications: 

  • Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for
    cell-growth promoting activity and transforming activity1
  • Cys-106 is easily oxidized to sulfinic acid1
  • Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative
  • Ubiquitination2 at Lys41, Lys99, Lys148
  • Modification sites at PhosphoSitePlus

  • See PARK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116849.1  NP_009193.2  

    ENSEMBL proteins: 
     ENSP00000465404   ENSP00000340278   ENSP00000418770   ENSP00000466242   ENSP00000366711  
     ENSP00000366708   ENSP00000466756  

    PARK7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PARK7
    OriGene Protein Over-expression Lysate for PARK7
    OriGene MassSpec for PARK7
    OriGene Custom Protein Services for PARK7
    GenScript Custom Purified and Recombinant Proteins Services for PARK7
    Novus Biologicals PARK7 Proteins
    Novus Biologicals PARK7 Lysates
    Sino Biological Recombinant Protein for PARK7
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PARK7
    Cloud-Clone Corp. Proteins for PARK7

    Search eBioscience for Proteins for PARK7 

    antibodies-online proteins for PARK7 (26 products) 

    antibodies-online peptides for PARK7

    Search GeneTex for Proteins for PARK7 

    PARK7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARK7
    R&D Systems Antibodies for PARK7 (Park7/DJ-1)
    Cell Signaling Technology (CST) Antibodies for PARK7  (DJ-1)
    OriGene Antibodies for PARK7
    OriGene Custom Antibody Services for PARK7
    Novus Biologicals PARK7 Antibodies
    Abcam antibodies for PARK7
    Cloud-Clone Corp. Antibodies for PARK7
    ThermoFisher Antibody for PARK7
    antibodies-online antibodies for PARK7 (175 products) 

    GeneTex Antibodies for PARK7:  
                        PARK7 Antibodies

    PARK7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PARK7
    R&D Systems ELISAs for PARK7 (Park7/DJ-1)
    GenScript Custom Assay Services for PARK7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PARK7
    Cloud-Clone Corp. CLIAs for PARK7
    Search eBioscience for ELISAs for PARK7 
    antibodies-online kits for PARK7 (12 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    PARK: Parkinson disease

    2 InterPro protein domains:
     IPR006287 DJ1
     IPR002818 ThiJ/PfpI

    Graphical View of Domain Structure for InterPro Entry Q99497

    ProtoNet protein and cluster: Q99497

    1 Blocks protein domain: IPB002818 Family of unknown function ThiJ/PfpI

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Similarity: Belongs to the peptidase C56 family

    Find genes that share domains with PARK7           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARK7_HUMAN, Q99497
    Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
    stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
    substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
    L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
    peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
    peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
    action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
    its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
    translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
    their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
    function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
    positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
    fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
    function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and
    neuronal cells
    Biophysicochemical properties: Kinetic parameters: KM=173.4 uM for casein;
    Induction: By hydrogen peroxide and UV irradiation

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA18626009
    GO:0004601peroxidase activity ISS--
    GO:0005515protein binding IPI11477070
    GO:0008233peptidase activity IDA--
    GO:0042803protein homodimerization activity IDA18711745
    Find genes that share ontologies with PARK7           About GenesLikeMe

         1 GenomeRNAi human phenotype for PARK7:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Park7):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with PARK7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PARK7: Park7tm1Cai Park7tm1Tmd Park7tm1Xz Park7tm1Shn Park7tm1Dsp

       genOway: Develop your customized and physiologically relevant rodent model for PARK7

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for PARK7

    miRTarBase miRNAs that target PARK7:
    hsa-mir-92b-3p (MIRT040717), hsa-mir-222-3p (MIRT046823), hsa-mir-92a-3p (MIRT049137), hsa-mir-26b-5p (MIRT029955)

    Block miRNA regulation of human, mouse, rat PARK7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PARK7
    SwitchGear 3'UTR luciferase reporter plasmidPARK7 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for PARK7
    Predesigned siRNA for gene silencing in human, mouse, rat PARK7

    OriGene clones in human, mouse for PARK7 (see all 12)
    OriGene ORF clones in mouse, rat for PARK7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PARK7 (NM_007262)
    Sino Biological Human cDNA Clone for PARK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARK7
    Addgene plasmids for PARK7 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for PARK7
    Browse ESI BIO Cell Lines and PureStem Progenitors for PARK7 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    PARK7_HUMAN, Q99497: Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Note=Under
    normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and
    mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress
    and exerts an increased cytoprotective effect against oxidative damage. Detected in tau inclusions in brains from
    neurodegenerative disease patients. Membrane raft localization in astrocytes and neuronal cells requires
    Subcellular locations from COMPARTMENTS: 


    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11477070
    GO:0005737cytoplasm IDA12446870
    GO:0005739mitochondrion IMP--
    GO:0005829cytosol IMP--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with PARK7           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for PARK7 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    2Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    3TNF Signaling
    Death Receptor Signaling0.50
    4CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31
    5PI3K / Akt Signaling
    PI3K / Akt Signaling

    Find genes that share SuperPaths with PARK7           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PARK7
        Parkinson's Disease Pathway

    2 Cell Signaling Technology (CST) Pathways for PARK7
    PI3K / Akt Signaling

    4 BioSystems Pathways for PARK7
        Parkinsons Disease Pathway
    Androgen receptor signaling pathway
    Synaptic Vesicle Pathway
    Alpha-synuclein signaling

    1 Sino Biological Pathway for PARK7
        Death Receptor Signaling

    1 Kegg Pathway  (Kegg details for PARK7):
        Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat


        GeneGlobe Interaction Network for PARK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARK7 (Q994971, 2, 3 ENSP000003402784) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206206Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000206279Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000227046Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000231617Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    MTA2O947761, 3, ENSP000002788234EBI-1164361,EBI-1783035 I2D: score=2 STRING: ENSP00000278823
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ----
    GO:0006508proteolysis ----
    GO:0006914autophagy IEA--
    GO:0006954inflammatory response IEA--
    GO:0007005mitochondrion organization ISS--

    Find genes that share ontologies with PARK7           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PARK7

    1 DrugBank Compound for PARK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Double Oxidized Cysteine-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for PARK7 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    e 64d 76.3 9 15365989 (3), 17451229 (1), 20186336 (1), 15663963 (1)
    sulfinic acid 59.7 3 16403519 (2), 16181642 (1)
    rotenone 56 8 18377993 (3), 16439141 (2), 16854843 (2), 18930142 (1)
    6-hydroxydopamine 51.9 8 18377993 (3), 18974921 (1), 16860563 (1), 16227205 (1) (see all 5)
    dopamine 46.9 33 16978583 (4), 18974921 (4), 19703902 (3), 16227205 (2) (see all 9)
    cysteine 34.6 35 16316629 (3), 19124468 (2), 16935423 (2), 18570440 (2) (see all 13)
    h2o2 30.8 20 16935423 (2), 15081400 (2), 20046643 (2), 14652021 (1) (see all 10)
    levodopa 29.9 1 19703902 (1)
    oxygen 17.5 13 16403519 (1), 16115732 (1), 18430896 (1), 15219840 (1) (see all 12)
    pyrimidine 14.5 4 16731528 (2), 15790595 (1), 18689799 (1)

    Find genes that share compounds with PARK7           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for PARK7 gene (3 alternative transcripts): 
    NM_001123377.1  NM_007262.4  XM_005263424.1  

    Unigene Cluster for PARK7:

    Parkinson protein 7
    Hs.419640  [show with all ESTs]
    Unigene Representative Sequence: BF965121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493373 ENST00000460192 ENST00000338639(uc001aou.4 uc001aox.4 uc001aov.4)
    ENST00000493678 ENST00000377493 ENST00000465354 ENST00000377491 ENST00000377488
    ENST00000497113 ENST00000469225
    Block miRNA regulation of human, mouse, rat PARK7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PARK7
    SwitchGear 3'UTR luciferase reporter plasmidPARK7 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for PARK7
    Predesigned siRNA for gene silencing in human, mouse, rat PARK7
    OriGene clones in human, mouse for PARK7 (see all 12)
    OriGene ORF clones in mouse, rat for PARK7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PARK7 (NM_007262)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARK7
    Addgene plasmids for PARK7 
    OriGene qPCR primer pairs and template standards for PARK7
    OriGene qSTAR qPCR primer pairs in human, mouse for PARK7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARK7
      QuantiTect SYBR Green Assays in human, mouse, rat PARK7
      QuantiFast Probe-based Assays in human, mouse, rat PARK7

    Additional mRNA sequence: 

    AB073864.1 AF021819.1 AK130886.1 AK312000.1 BC008188.2 D61380.2 

    Selected DOTS entries (see all 30):

    DT.100864956  DT.448826  DT.91912005  DT.100864954  DT.100864946  DT.99944190  DT.91858715  DT.100723157 
    DT.121340910  DT.95171052  DT.100864949  DT.100864951  DT.100864952  DT.95171053  DT.91717622  DT.95171037 
    DT.100864945  DT.100864955  DT.121340885  DT.121340900  DT.121340908  DT.121340933  DT.121340949  DT.91778970 

    Selected AceView cDNA sequences (see all 818):

    AA251345 AI202676 BM760109 BM750124 BM756505 C05103 AL556933 CB996016 
    CR623919 AJ709120 BM741700 CR591123 CD050392 AI761742 BM759196 CD672896 
    BM704825 BM824731 BQ028408 BM760888 BM760169 AA602784 BU657605 AA039588 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PARK7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -     -     -     -                                         -     -                                 
    SP2:                          -     -     -                                         -     -                                 
    SP3:                                                                                -     -                                 
    SP4:                    -     -     -     -                 -     -                 -     -                                 
    SP5:                                      -                                         -     -                                 

    ECgene alternative splicing isoforms for PARK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    PARK7 Expression
    About this image

    PARK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     Ovary (Reproductive System)
     Pancreas (Endocrine System)
             Islets of Langerhans
    PARK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARK7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419640

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at
    slightly lower levels in placenta and brain. Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat

    OriGene qPCR primer pairs and template standards for PARK7
    OriGene qSTAR qPCR primer pairs in human, mouse for PARK7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARK7
    QuantiTect SYBR Green Assays in human, mouse, rat PARK7
    QuantiFast Probe-based Assays in human, mouse, rat PARK7
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PARK7 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Park71 , 5 Parkinson disease (autosomal recessive, early onset) more1, 5 84.3(n)1
      4 (81.52 cM)5
    573201  NM_020569.31  NP_065594.21 
    (Gallus gallus)
    Aves PARK71 Parkinson disease (autosomal recessive, early onset) more 79.37(n)
      395277  NM_204585.1  NP_989916.1 
    (Anolis carolinensis)
    Reptilia PARK76
    parkinson protein 7
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114132 Xenopus laevis SP22 mRNA, complete cds 77.13(n)    AF394958.1 
    (Danio rerio)
    Actinopterygii Dr.155302 Transcribed sequence with moderate similarity to protein more 74.28(n)    BM317196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DJ-1alpha1 DJ-1alpha 54.68(n)
      36543  NM_137072.1  NP_610916.1 
    (Caenorhabditis elegans)
    Secernentea djr-1.11 djr-1.1 57.3(n)
      173416  NM_061295.6  NP_493696.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G532801 AT1G53280 50(n)
      841762  NM_104206.3  NP_564626.1 
    (Oryza sativa)
    Liliopsida Os06g05312001 Os06g0531200 48.4(n)
      4341205  NM_001064318.1  NP_001057783.2 

    ENSEMBL Gene Tree for PARK7 (if available)
    TreeFam Gene Tree for PARK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for PARK7 gene

    Find genes that share paralogs with PARK7           About GenesLikeMe

    2 Pseudogenes for PARK7
    PGOHUM00000239770 PGOHUM00000236716

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for PARK7 (see all 593)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 1 posSequence#AA
    C,FParkinson disease 7 (PARK7)4 pathogenic18062522(+) AAAAGA/CCGGCC 4 D A mis11Minor allele frequency- C:0.00NA 4552
    CParkinson disease 7 (PARK7)4 pathogenic18062573(+) TGCGCC/TTGCAA 4 P L mis10--------
    Parkinson disease 7 (PARK7)4--see VAR_0204932 E D mis40--------
    Parkinson disease 7 (PARK7)4--see VAR_0204922 M I mis40--------
    Parkinson disease 7 (PARK7)4--see VAR_0204952 A T mis40--------
    Cpathogenic18040457(+) GTCATA/GAGGCG 4 I M mis10--------
    Cpathogenic18043019(+) AAAGAC/GGTTTG 4 D E mis10--------
    C--8029645(+) CAAAC-/TTTTTTT 2 -- int10--------
    --8037254(+) CCACTA/GTGGAA 2 -- us2k10--------
    --8037549(+) CTCGAA/GAGACT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARK7 (8014351 - 8045565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PARK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1521CNV Insertion18451855
    nsv871360CNV Gain21882294

    Human Gene Mutation Database (HGMD): PARK7
    Locus Specific Mutation Databases (LSDB): PARK7

    1 Site Specific Mutation Identification with PCR Assay for PARK7:
    Cosmic IdAA Change
    SeqTarget long-range PCR primers for resequencing PARK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 602533   
    OMIM disorders: 606324  
    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
  • Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor,
    postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40
    years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of
    amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 6 diseases for PARK7:    
    About MalaCards
    park7-related parkinson disease    parkinson disease 7, autosomal recessive early-onset    spinocerebellar ataxia type 17    parkinson's disease
    amyotrophic lateral sclerosis-parkinsonism/dementia complex    parkinson disease 1

    1 inferred disease relationship from the University of Copenhagen DISEASES database for PARK7:
    Parkinson's disease

    Find genes that share disorders with PARK7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PARK7 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 89.2 181 20157014 (6), 14662519 (5), 15219840 (4), 14707326 (3) (see all 99)
    autosomal recessive parkinsonism 87.5 12 14638971 (3), 19429112 (2), 17914725 (1), 19297401 (1) (see all 7)
    parkinsonism 85.4 87 19429112 (5), 15565491 (2), 19124468 (2), 15542239 (2) (see all 47)
    parkinsonism juvenile autosomal recessive 81 10 14652021 (1), 14745011 (1), 17268184 (1), 19243613 (1) (see all 8)
    parkinson disease, autosomal dominant 76.4 2 15717024 (1)
    neurodegenerative diseases 74.9 18 19686841 (2), 14705119 (2), 17719794 (2), 18930142 (1) (see all 12)
    neurodegeneration 65.1 11 14712351 (2), 19023331 (1), 16115732 (1), 16439141 (1) (see all 9)
    movement disorders 64 1 18704525 (1)
    tauopathies 57.9 8 14991385 (2), 15935068 (1), 17085780 (1), 14705119 (1)
    lewy body disease 38.6 1 14625045 (1)

    GeneTests: PARK7
    GeneReviews: PARK7
    Genetic Association Database (GAD): PARK7
    Human Genome Epidemiology (HuGE) Navigator: PARK7 (24 documents)

    Export disorders for PARK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARK7 gene, integrated from 10 sources (see all 417) (see top 10):
    (articles sorted by number of sources associating them with PARK7)

    1. DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. (PubMed id 14872018)1, 2, 4, 9 Hedrich K.... Klein C. (Neurology 2004)
    2. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. (PubMed id 9070310)1, 2, 3, 9 Nagakubo D.... Ariga H. (Biochem. Biophys. Res. Commun. 1997)
    3. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. (PubMed id 18711745)1, 2, 9 Junn E.... Mouradian M.M. (J. Neurosci. Res. 2009)
    4. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. (PubMed id 14662519)1, 2, 9 Bandopadhyay R.... Lees A.J. (Brain 2004)
    5. DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. (PubMed id 16390825)1, 2, 9 Sekito A....Ariga H. (Free Radic. Res. 2006)
    6. The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. (PubMed id 12855764)1, 2, 9 Wilson M.A.... Petsko G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo- oligomerization. (PubMed id 14713311)1, 2, 9 Moore D.J.... Dawson V.L. (J. Neurochem. 2003)
    8. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. (PubMed id 12914946)1, 2, 9 Huai Q.... Ke H. (FEBS Lett. 2003)
    9. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. (PubMed id 11223268)1, 2, 9 Taira T.... Ariga H. (Gene 2001)
    10. Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism. (PubMed id 19429112)1, 4, 9 Tomiyama H....Hattori N. (Neurosci. Lett. 2009)
    11. The role of pathogenic DJ-1 mutations in Parkinson's disease. (PubMed id 12953260)1, 2, 9 Abou-Sleiman P.M.... Wood N.W. (Ann. Neurol. 2003)
    12. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. (PubMed id 11477070)1, 2, 9 Takahashi K....Ariga H. (J. Biol. Chem. 2001)
    13. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. (PubMed id 20186336)1, 2, 9 Krebiehl G.... Kruger R. (PLoS ONE 2010)
    14. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. (PubMed id 18626009)1, 2, 9 van der Brug M.P.... Cookson M.R. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    15. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. (PubMed id 17015834)1, 2, 9 Clements C.M.... Ting J.P. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    16. Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity. (PubMed id 15308309)1, 4, 9 Tan E.K....Wong M.C. (Neurosci. Lett. 2004)
    17. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. (PubMed id 15181200)1, 2, 9 Canet-Aviles R.M.... Cookson M.R. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    18. Detection of Parkin (PARK2) and DJ1 (PARK7) mutations in early-onset Parkinson disease: Parkin mutation frequency depends on ethnic origin of patients. (PubMed id 15108293)1, 4, 9 Djarmati A....Kostic V. (Hum. Mutat. 2004)
    19. Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism. (PubMed id 15372597)1, 4, 9 Lockhart P.J....Farrer M.J. (Mov. Disord. 2004)
    20. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. (PubMed id 17846173)1, 2, 9 Olzmann J.A....Chin L.S. (J. Cell Biol. 2007)
    21. Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. (PubMed id 14607841)1, 2, 9 Goerner K.... Kahle P.J. (J. Biol. Chem. 2004)
    22. Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. (PubMed id 12761214)1, 2, 9 Tao X. and Tong L. (J. Biol. Chem. 2003)
    23. DJ-1 is a Parkinson's disease susceptibility gene in southern Italy. (PubMed id 19968671)1, 4, 9 De Marco E.V....Quattrone A. (Clin. Genet. 2010)
    24. Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease. (PubMed id 18973254)1, 4, 9 Macedo M.G....Heutink P. (Mov. Disord. 2009)
    25. PINK1, Parkin, and DJ-1 mutations in Italian patients with early- onset parkinsonism. (PubMed id 15970950)1, 4, 9 Klein C.... Pramstaller P.P. (Eur. J. Hum. Genet. 2005)
    26. Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). (PubMed id 15365989)1, 2, 9 Hering R....Riess O. (Hum. Mutat. 2004)
    27. [Association of the DJ-1 gene polymorphism with sporadic Parkinson's disease in Sichuan province of China]. (PubMed id 18841573)1, 4, 9 Chen W....Jiang Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    28. Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease. (PubMed id 18704525)1, 4, 9 Choi J.M....Kim Y.J. (Neurogenetics 2008)
    29. A deletion in DJ-1 and the risk of dementia--a population-based survey. (PubMed id 15542239)1, 4, 9 Arias VA!squez A....van Duijn C.M. (Neurosci. Lett. 2004)
    30. Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations. (PubMed id 15254937)1, 2, 9 Clark L.N....Marder K. (Mov. Disord. 2004)
    31. A limited role for DJ1 in Parkinson disease susceptibility. (PubMed id 15304593)1, 4, 9 Maraganore D.M....Farrer M.J. (Neurology 2004)
    32. DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia. (PubMed id 14705119)1, 2, 9 Rizzu P.... Heutink P. (Ann. Neurol. 2004)
    33. Mutations in the DJ-1 gene associated with autosomal recessive early- onset Parkinsonism. (PubMed id 12446870)1, 2, 9 Bonifati V.... Heutink P. (Science 2003)
    34. L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. (PubMed id 12851414)1, 2, 9 Miller D.W.... Cookson M.R. (J. Biol. Chem. 2003)
    35. Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population. (PubMed id 19405094)1, 4, 9 Nuytemans K....Theuns J. (Hum. Mutat. 2009)
    36. Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism. (PubMed id 18722801)1, 4, 9 Tarantino P....Quattrone A. (amp 2009)
    37. Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia. (PubMed id 18486522)1, 4, 9 Mellick G.D....Hattori N. (amp 2009)
    38. DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex. (PubMed id 16240358)1, 2, 9 Annesi G....Quattrone A. (Ann. Neurol. 2005)
    39. Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease. (PubMed id 14625045)1, 4, 9 Morris C.M....Singleton A.B. (Neurosci. Lett. 2003)
    40. Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD. (PubMed id 14557580)1, 4, 9 Eerola J....Singleton A.B. (Neurology 2003)
    41. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    42. DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. (PubMed id 21097510)1, 2 McNally R.S.... Ting J.P. (J. Biol. Chem. 2011)
    43. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    44. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    45. Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism. (PubMed id 20146068)1, 4 Guo J.F....Tang B.S. (J. Neurol. 2010)
    46. Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. (PubMed id 20304780)1, 2 Chen J.... Chin L.S. (Hum. Mol. Genet. 2010)
    47. Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? (PubMed id 19224617)1, 4 Sutherland G.T....Mellick G.D. (Mov. Disord. 2009)
    48. Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. (PubMed id 15976810)1, 2 Shinbo Y.... Ariga H. (Cell Death Differ. 2006)
    49. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    50. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    51. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    52. DJ-1 has a role in antioxidative stress to prevent cell death. (PubMed id 14749723)1, 2 Taira T....Ariga H. (EMBO Rep. 2004)
    53. The R98Q variation in DJ-1 represents a rare polymorphism. (PubMed id 14705128)1, 2 Hedrich K....Klein C. (Ann. Neurol. 2004)
    54. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha- synuclein aggregate formation. (PubMed id 15502874)1, 2 Shendelman S.... Abeliovich A. (PLoS Biol. 2004)
    55. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    56. The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. (PubMed id 12796482)1, 2 Honbou K....Inagaki F. (J. Biol. Chem. 2003)
    57. Immunocytochemical localization of DJ-1 in human male reproductive tissue. (PubMed id 14579415)1, 2 Yoshida K.... Iwamoto T. (Mol. Reprod. Dev. 2003)
    58. Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. (PubMed id 12939276)1, 2 Lee S.-J.... Cha S.-S. (J. Biol. Chem. 2003)
    59. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. (PubMed id 12612053)1, 2 Niki T.... Ariga H. (Mol. Cancer Res. 2003)
    60. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. (PubMed id 11462174)1, 3 van Duijn C.M....Heutink P. (Am. J. Hum. Genet. 2001)
    61. Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. (PubMed id 19885556)1, 9 Kim Y.C....Ariga H. (Int. J. Oncol. 2009)
    62. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. (PubMed id 15944198)1, 9 Zhang L....Dawson V.L. (Hum. Mol. Genet. 2005)
    63. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. (PubMed id 16227205)1, 9 Zhou W. and Freed C.R. (J. Biol. Chem. 2005)
    64. DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age. (PubMed id 18647263)1, 9 Mullett S.J....Hinkle D.A. (Neuropathology 2009)
    65. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. (PubMed id 15525661)1, 9 Moore D.J....Dawson V.L. (Hum. Mol. Genet. 2005)
    66. DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. (PubMed id 16731528)1, 9 Zhong N....Xu J. (J. Biol. Chem. 2006)
    67. Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. (PubMed id 17120294)1, 9 Olzmann J.A....Chin L.S. (J. Comp. Neurol. 2007)
    68. Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis. (PubMed id 17034344)1, 9 Lev N....Offen D. (amp 2006)
    69. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. (PubMed id 19703902)1, 9 Ishikawa S....Iguchi-Ariga S.M. (J. Biol. Chem. 2009)
    70. DJ-1 protects against dopamine toxicity. (PubMed id 18974921)1, 9 Lev N....Offen D. (J Neural Transm 2009)
    71. Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells. (PubMed id 18430896)1, 9 Zhang H.Y....Du Z.X. (Endocr. Relat. Cancer 2008)
    72. Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation. (PubMed id 18689799)1, 9 Zhong N. and Xu J. (Hum. Mol. Genet. 2008)
    73. DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. (PubMed id 19064576)1, 9 Yuen H.F....Chan K.W. (amp 2008)
    74. DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. (PubMed id 17487420)1, 9 Koide-Yoshida S....Ariga H. (Int. J. Mol. Med. 2007)
    75. DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents. (PubMed id 17599367)1, 9 Galter D....Olson L. (amp 2007)
    76. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. (PubMed id 16517609)1, 9 Choi J....Li L. (J. Biol. Chem. 2006)
    77. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. (PubMed id 16403519)1, 9 Zhou W....Fink A.L. (J. Mol. Biol. 2006)
    78. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. (PubMed id 15935068)1, 9 Meulener M.C....Giasson B.I. (J. Neurochem. 2005)
    79. Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress. (PubMed id 20127688)1, 9 Opsahl J.A....Fladmark K.E. (Proteomics 2010)
    80. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. (PubMed id 19680261)1, 9 Giaime E....Alves da Costa C. (Cell Death Differ. 2010)
    81. DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. (PubMed id 19686841)1, 9 Kahle P.J....Gasser T. (amp 2009)
    82. Proteomic analysis of oxidative stress-responsive proteins in human pneumocytes: insight into the regulation of DJ-1 expression. (PubMed id 18817430)1, 9 Duan X....Merali S. (J. Proteome Res. 2008)
    83. Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma. (PubMed id 17949781)1, 9 Davidson B....Reich R. (Hum. Pathol. 2008)
    84. Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease. (PubMed id 17451229)1, 9 Hulleman J.D....Rochet J.C. (Biochemistry 2007)
    85. Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. (PubMed id 14665635)1, 9 Olzmann J.A....Chin L.S. (J. Biol. Chem. 2004)
    86. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. (PubMed id 14652021)1, 9 Yokota T....Mizusawa H. (Biochem. Biophys. Res. Commun. 2003)
    87. Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene. (PubMed id 19825160)1, 9 Keyser R.J....Bardien S. (BMC Med. Genet. 2009)
    88. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. (PubMed id 18042550)1, 9 Fan J....Wang G. (J. Biol. Chem. 2008)
    89. DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70. (PubMed id 18382667)1, 9 Batelli S....Forloni G. (PLoS ONE 2008)
    90. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. (PubMed id 15790595)1, 9 Xu J....Yankner B.A. (Hum. Mol. Genet. 2005)
    91. DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. (PubMed id 19144925)1, 9 Vasseur S....Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    92. Differential DJ-1 gene expression in Parkinson's disease. (PubMed id 19716892)1, 9 Kumaran R....Bandopadhyay R. (Neurobiol. Dis. 2009)
    93. Expression and role of DJ-1 in leukemia. (PubMed id 18722352)1, 9 Liu H....Wang J. (Biochem. Biophys. Res. Commun. 2008)
    94. DJ-1: a newcomer in Parkinson's disease pathology. (PubMed id 18045143)1, 9 da Costa C.A. (Curr. Mol. Med. 2007)
    95. Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. (PubMed id 15219840)1, 9 Takahashi-Niki K....Ariga H. (Biochem. Biophys. Res. Commun. 2004)
    96. Prognostic significance of nuclear DJ-1 expression in astrocytoma. (PubMed id 20150646)1, 9 Miyajima Y....Fujii K. (Anticancer Res. 2010)
    97. DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. (PubMed id 20213747)1, 9 Mo J.S....Park H.S. (J. Cell. Biochem. 2010)
    98. BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity. (PubMed id 20156966)1, 9 Deeg S....Kermer P. (J. Cell Biol. 2010)
    99. Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. (PubMed id 19124468)1, 9 Blackinton J....Wilson M.A. (J. Biol. Chem. 2009)
    100. The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma. (PubMed id 19384955)1, 9 Sitaram R.T....Roos G. (Int. J. Cancer 2009)
    101. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. (PubMed id 19229105)1, 9 Xiong H....Zhang Z. (J. Clin. Invest. 2009)
    102. Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. (PubMed id 18706098)1, 9 Tian M....Han J.X. (BMC Cancer 2008)
    103. Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism. (PubMed id 18785233)1, 9 Guo J.F....Tang B.S. (Mov. Disord. 2008)
    104. DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. (PubMed id 17510388)1, 9 Tillman J.E....Kasper S. (Cancer Res. 2007)
    105. Association of PINK1 and DJ-1 confers digenic inheritance of early- onset Parkinson's disease. (PubMed id 16632486)1, 9 Tang B.... Zhang Z. (Hum. Mol. Genet. 2006)
    106. Role of DJ-1 in Parkinson's disease. (PubMed id 17085780)1, 9 Lev N....Offen D. (J. Mol. Neurosci. 2006)
    107. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. (PubMed id 15983381)1, 9 Junn E....Mouradian M.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    108. DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. (PubMed id 15703819)1, 9 Shinbo Y....Ariga H. (Int. J. Oncol. 2005)
    109. DJ-1, a novel regulator of the tumor suppressor PTEN. (PubMed id 15766664)1, 9 Kim R.H....Mak T.W. (Cancer Cell 2005)
    110. Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. (PubMed id 18922803)1, 9 Cha S.S....Kang S.O. (J. Biol. Chem. 2008)
    111. Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. (PubMed id 16316629)1, 9 Ito G....Iwatsubo T. (Biochem. Biophys. Res. Commun. 2006)
    112. Screening for DJ-1 mutations in early onset autosomal recessive parkinsonism. (PubMed id 14638971)1, 9 IbA!A+ez P....Brice A. (Neurology 2003)
    113. Genotype-phenotype correlates in Taiwanese patients with early-onset recessive Parkinsonism. (PubMed id 19006224)1, 9 Lee M.J....Wu R.M. (Mov. Disord. 2009)
    114. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. (PubMed id 19692353)1, 9 Venderova K....Park D.S. (Hum. Mol. Genet. 2009)
    115. Cysteine pKa depression by a protonated glutamic acid in human DJ-1. (PubMed id 18570440)1, 9 Witt A.C....Wilson M.A. (Biochemistry 2008)
    116. Structural effects of Parkinson's disease linked DJ-1 mutations. (PubMed id 18436956)1, 9 Malgieri G. and Eliezer D. (Protein Sci. 2008)
    117. On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study. (PubMed id 17504761)1, 9 Herrera F.E....Carloni P. (J. Biol. Chem. 2007)
    118. The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation. (PubMed id 20406884)1, 9 Xu X.M....ller S.G. (J. Cell. Sci. 2010)
    119. Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations. (PubMed id 19023331)1, 9 Zucchelli S....Gustincich S. (Cell Death Differ. 2009)
    120. Silencing DJ-1 reveals its contribution in paraquat-induced autophagy. (PubMed id 19425177)1, 9 GonzA!lez-Polo R....Fuentes J.M. (J. Neurochem. 2009)
    121. The E163K DJ-1 mutant shows specific antioxidant deficiency. (PubMed id 18822273)1, 9 Ramsey C.P. and Giasson B.I. (Brain Res. 2008)
    122. LRRK2 gene in Parkinson disease: mutation analysis and case control association study. (PubMed id 16157901)1, 9 Paisan-Ruiz C....Rogaeva E. (Neurology 2005)
    123. Genetics of Parkinson disease. (PubMed id 15717024)1, 9 Pankratz N. and Foroud T. (NeuroRx 2004)
    124. Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. (PubMed id 14712351)1, 9 Bonifati V....Heutink P. (J. Mol. Med. 2004)
    125. DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function. (PubMed id 14985393)1, 9 Lockhart P.J....Farrer M.J. (J. Med. Genet. 2004)
    126. DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism. (PubMed id 14598065)1, 9 Bonifati V....Heutink P. (Neurol. Sci. 2003)
    127. A clinical-genetic study of Parkinson's disease in a genetically isolated community. (PubMed id 14504966)4, 9 Dekker M.C....van Duijn C.M. (J. Neurol. 2003)
    128. Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7. (PubMed id 12548343)1, 9 Bonifati V....Heutink P. (Neurol. Sci. 2002)
    129. Incidence of mutations in the PARK2, PINK1, PARK7 genes in Polish early-onset Parkinson disease patients. (PubMed id 23986421)1 Koziorowski D....Friedman A. (Neurol. Neurochir. Pol. 2013)
    130. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    131. Expression of DJ-1 proteins in placentas from women with severe preeclampsia. (PubMed id 23347603)1 Kwon H.S....Park S.H. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2013)
    132. Expression of DJ-1 in endometrial cancer: close correlation with clinicopathological features and apoptosis. (PubMed id 23727824)1 Shu K....Mei T. (Int. J. Gynecol. Cancer 2013)
    133. DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. (PubMed id 23847046)2 Kim K.S.... Park S.M. (Hum. Mol. Genet. 2013)
    134. Altered expression of DJ-1 and PINK1 in sporadic ALS and in the SOD1(G93A) ALS mouse model. (PubMed id 24128678)1 Knippenberg S....Petri S. (J. Neuropathol. Exp. Neurol. 2013)
    135. Identification of the recognition sequence and target proteins for DJ-1 protease. (PubMed id 23831022)1 Mitsugi H....Ariga H. (FEBS Lett. 2013)
    136. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    137. Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. (PubMed id 23792957)1 BjAPrkblom B....ller S.G. (J. Biol. Chem. 2013)
    138. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. (PubMed id 23015639)1 Klawitter J....Seres T. (Cardiovasc. Res. 2013)
    139. DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. (PubMed id 23743200)1 Yasuda T....Iguchi-Ariga S.M. (Biochem. Biophys. Res. Commun. 2013)
    140. Peroxiredoxins and their expression in ependymomas. (PubMed id 23076395)1 Haapasalo T....Soini Y. (J. Clin. Pathol. 2013)
    141. DJ-1 regulates mast cell activation and IgE-mediated allergic responses. (PubMed id 23182168)1 Kim d.o. .K....Choi W.S. (J. Allergy Clin. Immunol. 2013)
    142. Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner. (PubMed id 23149933)1 Kato I....Ariga H. (Mol. Cell. Biol. 2013)
    143. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    144. DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE). (PubMed id 23844142)1 Shadrach K.G....Bonilha V.L. (PLoS ONE 2013)
    145. Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO. (PubMed id 23593018)1 Hwang S....Cho K.S. (PLoS Genet. 2013)
    146. The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering. (PubMed id 23418303)1 Ottolini D....Brini M. (Hum. Mol. Genet. 2013)
    147. ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1. (PubMed id 23447676)1 Duplan E....Alves da Costa C. (J. Cell. Sci. 2013)
    148. Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo. (PubMed id 23530187)1 Billia F....Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    149. DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients. (PubMed id 23592371)1 Kawate T....Kohno N. (Breast Cancer Res. Treat. 2013)
    150. DJ-1 upregulates tyrosine hydroxylase gene expression by activating its transcriptional factor Nurr1 via the ERK1/2 pathway. (PubMed id 22024154)1 Lu L....Yang H. (amp 2012)
    151. Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. (PubMed id 22428580)1 Wang X....Zhu X. (J. Neurochem. 2012)
    152. Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer. (PubMed id 21943684)1 Merikallio H....Soini Y. (Hum. Pathol. 2012)
    153. Genetic bases and phenotypes of autosomal recessive Parkinson disease in a Turkish population. (PubMed id 22233331)1 Lohmann E....Emre M. (Eur. J. Neurol. 2012)
    154. Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation. (PubMed id 22571429)1 Chen C.Y. (amp 2012)
    155. Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. (PubMed id 23151319)1 Zhu X.L....Wen W.P. (amp 2012)
    156. Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. (PubMed id 22666465)1 Yamaguchi S....Ariga H. (PLoS ONE 2012)
    157. Biochemical premotor biomarkers for Parkinson's disease. (PubMed id 22508282)1 Mollenhauer B. and Zhang J. (Mov. Disord. 2012)
    158. Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome. (PubMed id 22173095)1 Alvarez-Castelao B....CastaA+o J.G. (Biochim. Biophys. Acta 2012)
    159. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    160. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    161. DJ-1 may contribute to metastasis of non-small cell lung cancer. (PubMed id 21670963)1 Bai J....Fu S. (Mol. Biol. Rep. 2012)
    162. Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells. (PubMed id 22554508)1 Ishikawa S....Iguchi-Ariga S.M. (Biochem. Biophys. Res. Commun. 2012)
    163. Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. (PubMed id 22511790)1 Haque M.E....Park D.S. (J. Biol. Chem. 2012)
    164. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    165. Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6. (PubMed id 22532838)1 Vilotti S....Zucchelli S. (PLoS ONE 2012)
    166. The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. (PubMed id 22555455)1 Robert G....Auberger P. (Cell Death Differ. 2012)
    167. DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer. (PubMed id 22526154)1 Chen Y....Wu Y. (J. Cancer Res. Clin. Oncol. 2012)
    168. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. (PubMed id 22892098)1 Ren H....Wang G. (Mol Neurodegener 2012)
    169. Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1. (PubMed id 22515803)1 Lin J....Wilson M.A. (Biochemistry 2012)
    170. Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease. (PubMed id 22445250)1 Yonova-Doing E....Bonifati V. (amp 2012)
    171. DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. (PubMed id 22492997)1 Im J.Y....Mouradian M.M. (Hum. Mol. Genet. 2012)
    172. YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome. (PubMed id 22157000)1 Le H.T....Richarme G. (J. Biol. Chem. 2012)
    173. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats. (PubMed id 22664331)1 Sun S.Y....Pu X.P. (Brain Res. Bull. 2012)
    174. YajL, the prokaryotic homolog of the Parkinsonism-associated protein DJ-1, protects cells against protein sulfenylation. (PubMed id 22321799)1 Gautier V....Richarme G. (J. Mol. Biol. 2012)
    175. DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. (PubMed id 23250426)1 Kim J.M....Suh P.G. (Nat Commun 2012)
    176. Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas. (PubMed id 22968650)1 Shimwell N.J....Johnson P.J. (Br. J. Cancer 2012)
    177. Uncovering suitable reference proteins for expression studies in human adipose tissue with relevance to obesity. (PubMed id 22272336)1 PAcrez-PAcrez R....Peral B. (PLoS ONE 2012)
    178. DJ-1 variants in Indian Parkinson's disease patients. (PubMed id 22960331)1 Sadhukhan T....Ray J. (Dis. Markers 2012)
    179. Human DJ-1 and its homologs are novel glyoxalases. (PubMed id 22523093)1 Lee J.Y....Park C. (Hum. Mol. Genet. 2012)
    180. DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. (PubMed id 22223849)1 He X....Yuan Y. (Carcinogenesis 2012)
    181. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. (PubMed id 21785459)1 Fu K....Wang G. (Oncogene 2012)
    182. Comparative secretome analyses using a hollow fiber culture system with label-free quantitative proteomics indicates the influence of PARK7 on cell proliferation and migration/invasion in lung adenocarcinoma. (PubMed id 22985211)1 Chang Y.H....Liao P.C. (J. Proteome Res. 2012)
    183. High levels of DJ-1 protein in nipple fluid of patients with breast cancer. (PubMed id 22404125)1 Oda M....Matsubara O. (Cancer Sci. 2012)
    184. Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy. (PubMed id 22836768)1 Bitar M.S....Jurkunas U.V. (amp 2012)
    185. Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. (PubMed id 22956510)1 Kilarski L.L....Morris H.R. (Mov. Disord. 2012)
    186. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    187. DJ-1 associates with synaptic membranes. (PubMed id 21645620)1 Usami Y....Hattori N. (Neurobiol. Dis. 2011)
    188. Multiple coregulatory control of tyrosine hydroxylase gene transcription. (PubMed id 21368136)1 Reddy S.D....Kumar R. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    189. DJ-1 regulation of mitochondrial function and autophagy through oxidative stress. (PubMed id 21317550)1 McCoy M.K. and Cookson M.R. (Autophagy 2011)
    190. DJ-1-Mediated protective effect of protocatechuic aldehyde against oxidative stress in SH-SY5Y cells. (PubMed id 21160133)1 Gao J.W....Ariga H. (J. Pharmacol. Sci. 2011)
    191. DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal growth factor receptor amplification. (PubMed id 20497343)1 Hinkle D.A....Hamilton R.L. (Neuropathology 2011)
    192. Significance and relationship between DJ-1 gene and surviving gene expression in laryngeal carcinoma. (PubMed id 21556124)1 Shen Z....Ding H. (Eur J Histochem 2011)
    193. Identification of an artificial peptide motif that binds and stabilizes reduced human DJ-1. (PubMed id 21893204)1 Premkumar L....Riedl S.J. (J. Struct. Biol. 2011)
    194. Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. (PubMed id 22132160)1 Miyama A....Noguchi N. (PLoS ONE 2011)
    195. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    196. Down-regulation of DJ-1 protein in the ejaculated spermatozoa from Chinese asthenozoospermia patients. (PubMed id 21575935)1 An C.N....Pu X.P. (Fertil. Steril. 2011)
    197. The role of DJ-1 in the pathogenesis of endometriosis. (PubMed id 21445310)1 Rai P. and Shivaji S. (PLoS ONE 2011)
    198. DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. (PubMed id 21645326)1 Wang Z....Chen S. (Mol Neurodegener 2011)
    199. Growth inhibitory effects of DJ-1-small interfering RNA on laryngeal carcinoma Hep-2 cells. (PubMed id 20300974)1 Shen Z....Guo J. (Med. Oncol. 2011)
    200. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    201. PRKN, DJ-1, and PINK1 screening identifies novel splice site mutation in PRKN and two novel DJ-1 mutations. (PubMed id 21322020)1 Ghazavi F....Elahi E. (Mov. Disord. 2011)
    202. Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90. (PubMed id 21819105)1 Knobbe C.B....Schmitt-Ulms G. (J. Proteome Res. 2011)
    203. [Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients]. (PubMed id 22066264)1 Lisitskaia K.V....Shishkin S.S. (Biomed Khim 2011)
    204. High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy. (PubMed id 21426932)1 Das F....Choudhury G.G. (Cell. Signal. 2011)
    205. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. (PubMed id 20940149)1 Thomas K.J....Cookson M.R. (Hum. Mol. Genet. 2011)
    206. Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. (PubMed id 21852238)1 Ren H....Wang G. (J. Biol. Chem. 2011)
    207. Evaluating intra-genetic variants of DJ-1 among Parkinson's disease patients of eastern India. (PubMed id 21535932)1 Sanyal J....Raghavendra Rao V. (Neurol. Res. 2011)
    208. DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection. (PubMed id 21796667)1 Wang Z....Ding J. (Ann. Neurol. 2011)
    209. TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains. (PubMed id 20634198)1 Zucchelli S....Gustincich S. (Hum. Mol. Genet. 2010)
    210. Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease. (PubMed id 20736773)1 Zhang H.J....Cheung A.N. (Int. J. Gynecol. Pathol. 2010)
    211. Inhibition of mitochondrial fusion by I+-synuclein is rescued by PINK1, Parkin and DJ-1. (PubMed id 20842103)1 Kamp F....Haass C. (EMBO J. 2010)
    212. DJ-1 as a modulator of autophagy: an hypothesis. (PubMed id 20730377)1 GonzA!lez-Polo R.A....Fuentes J.M. (ScientificWorldJournal 2010)
    213. DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells. (PubMed id 20510502)1 Ren H....Wang G. (Cancer Lett. 2010)
    214. [DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis]. (PubMed id 21055329)1 Zhu X.L....Wang X.R. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010)
    215. DJ-1 loss by glutaredoxin but not glutathione depletion triggers Daxx translocation and cell death. (PubMed id 20014998)1 Saeed U....Ravindranath V. (amp 2010)
    216. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. (PubMed id 20506312)1 Nuytemans K....Van Broeckhoven C. (Hum. Mutat. 2010)
    217. Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. (PubMed id 20395301)1 Foti R....Gustincich S. (J. Biol. Chem. 2010)
    218. [DJ-1 gene rearrangement mutation in patients with autosomal recessive early-onset parkinsonism using real-time PCR]. (PubMed id 20543466)1 Zhang H....Tang B. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010)
    219. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. (PubMed id 20639397)1 Irrcher I....Park D.S. (Hum. Mol. Genet. 2010)
    220. L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments. (PubMed id 20806408)1 Ramsey C.P. and Giasson B.I. (J. Neurosci. Res. 2010)
    221. Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease. (PubMed id 20540987)1 Shi M....Zhang J. (Neurosci. Lett. 2010)
    222. Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis. (PubMed id 20061558)1 Marcondes A.M....Deeg H.J. (Blood 2010)
    223. Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene. (PubMed id 20938049)1 Ishikawa S....Iguchi-Ariga S.M. (J. Biol. Chem. 2010)
    224. Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions. (PubMed id 20673799)1 van Horssen Vries H.E. (amp 2010)
    225. Increased DJ-1 and its prognostic significance in hepatocellular carcinoma. (PubMed id 21410067)1 Liu S....Yi J. (Hepatogastroenterology 2010)
    226. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    227. Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis. (PubMed id 19014922)1 Lee L.C....Lin J.Y. ( international journal of clinical chemistry 2009)
    228. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    229. [The expression of DJ-1 gene in human hepatocellular carcinoma and its relationship with tumor invasion and metastasis]. (PubMed id 19335984)1 Wu F....Huang Z.M. (Zhonghua Gan Zang Bing Za Zhi 2009)
    230. Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. (PubMed id 19293155)1 Waak J....Kahle P.J. (J. Biol. Chem. 2009)
    231. Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress. (PubMed id 19371728)1 Gu L....Yang H. (Biochem. Biophys. Res. Commun. 2009)
    232. Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients. (PubMed id 19733211)1 Saito Y....Niki E. (Neurosci. Lett. 2009)
    233. DJ-1 binds to mitochondrial complex I and maintains its activity. (PubMed id 19822128)1 Hayashi T....Iguchi-Ariga S.M. (Biochem. Biophys. Res. Commun. 2009)
    234. Structural impact of three Parkinsonism-associated missense mutations on human DJ-1. (PubMed id 18181649)1 Lakshminarasimhan M....Wilson M.A. (Biochemistry 2008)
    235. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    236. Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease. (PubMed id 18707128)1 Anderson P.C. and Daggett V. (Biochemistry 2008)
    237. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. (PubMed id 17882163)1 Yanagisawa D....Ariga H. (J. Cereb. Blood Flow Metab. 2008)
    238. Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients. (PubMed id 18632777)1 Hirotani M....Sasaki H. (Mult. Scler. 2008)
    239. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. (PubMed id 18556627)1 Malhotra D....Biswal S. (Am. J. Respir. Crit. Care Med. 2008)
    240. Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease. (PubMed id 18331584)1 Liu F....Rochet J.C. (J. Neurochem. 2008)
    241. DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains. (PubMed id 18586035)1 Tsuboi Y....Ariga H. (FEBS Lett. 2008)
    242. Secretion of DJ-1 into the serum of patients with Parkinson's disease. (PubMed id 18162323)1 Maita C....Ariga H. (Neurosci. Lett. 2008)
    243. [Effect of RNA interference mediated gene silencing of DJ-1 on proliferation of laryngeal carcinoma cell line Hep-2]. (PubMed id 18717316)1 Zhu X.L....Su Z.Z. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    244. Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1. (PubMed id 18439917)1 Zhang C....Wang X.L. (Biochim. Biophys. Acta 2008)
    245. Novel interaction partners of Bardet-Biedl syndrome proteins. (PubMed id 18000879)1 Oeffner F....Grzeschik K.H. (Cell Motil. Cytoskeleton 2008)
    246. Proteomic identification of down-regulation of oncoprotein DJ-1 and proteasome activator subunit 1 in hepatitis B virus-infected well-differentiated hepatocellular carcinoma. (PubMed id 17671684)1 Zhang D....Koay E.S. (Int. J. Oncol. 2007)
    247. The tumor suppressor PP2A Abeta regulates the RalA GTPase. (PubMed id 17540176)1 Sablina A.A....Hahn W.C. (Cell 2007)
    248. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    249. Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. (PubMed id 17331951)1 GAPrner K....Kahle P.J. (J. Biol. Chem. 2007)
    250. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. (PubMed id 16707095)1 Waragai M....Hashimoto M. (Biochem. Biophys. Res. Commun. 2006)
    251. Establishment of specific antibodies that recognize C106-oxidized DJ-1. (PubMed id 16781058)1 Ooe H....Ariga H. (Neurosci. Lett. 2006)
    252. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    253. PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease. (PubMed id 17017532)1 Heutink P. (J. Neural Transm. Suppl. 2006)
    254. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    255. The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. (PubMed id 16570276)1 Pardo M....Zitzmann N. (Int. J. Cancer 2006)
    256. Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. (PubMed id 15894486)1 Bandopadhyay R....Lees A.J. (Neurobiol. Dis. 2005)
    257. [Mutation analysis of DJ1 gene in patients with autosomal recessive early-onset Parkinsonism]. (PubMed id 16331561)1 Guo J.F....Cao L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    258. Causes of Parkinson's disease: genetics of DJ-1. (PubMed id 15503154)1 Abou-Sleiman P.M....Wood N.W. (Cell Tissue Res. 2004)
    259. The human plasma proteome: a nonredundant list developed by combination of four separate sources. (PubMed id 14718574)1 Anderson N.L....Lobley A. (amp 2004)
    260. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    261. Mutant genes responsible for Parkinson's disease. (PubMed id 15018843)1 Le W. and Appel S.H. (Curr Opin Pharmacol 2004)
    262. hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. (PubMed id 14752510)1 Gotoh T....Mori M. (Cell Death Differ. 2004)
    263. Clinical features and neuroimaging of PARK7-linked parkinsonism. (PubMed id 12815653)1 Dekker M....van Duijn C. (Mov. Disord. 2003)
    264. Pathways to Parkinsonism. (PubMed id 12526767)1 Cookson M.R. (Neuron 2003)
    265. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    266. Parkinson Disease Overview (PubMed id 20301402)1 Pagon R.A....Stephens K. (1993)
    267. (PubMed id 15958754)4 
    268. Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. (PubMed id 15258905)9 Hod Y. (J. Cell. Biochem. 2004)
    269. Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein. (PubMed id 15955416)9 Bandopadhyay R....Lees A.J. (Neurosci. Lett. 2005)
    270. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. (PubMed id 19243613)9 Baulac S....Xia W. (Mol Neurodegener 2009)
    271. Porcine DJ-1: cloning of PARK7 cDNA, sequence comparison, expression analysis and chromosomal localization. (PubMed id 17268184)9 Larsen K....Bendixen C. (Cytogenet. Genome Res. 2007)
    272. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. (PubMed id 20157014)9 Hong Z....Zhang J. (Brain 2010)
    273. Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection. (PubMed id 18377993)9 Lev N....Offen D. (Neurotoxicology 2008)
    274. Specific cleavage of DJ-1 under an oxidative condition. (PubMed id 16935423)9 Ooe H....Ariga H. (Neurosci. Lett. 2006)
    275. Localization of DJ-1 mRNA in the mouse brain. (PubMed id 15337248)9 Shang H....Kaelin-Lang A. (Neurosci. Lett. 2004)
    276. DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. (PubMed id 20133695)9 Aleyasin H....Park D.S. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    277. Identification of novel proteins associated with both alpha-synuclein and DJ-1. (PubMed id 16854843)9 Jin J....Zhang J. (amp 2007)
    278. In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized. (PubMed id 18601999)9 Terracciano C....Askanas V. (amp 2008)
    279. Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. (PubMed id 16298734)9 Li H.M....Ariga H. (Free Radic. Res. 2005)
    280. DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. (PubMed id 20089532)9 Ramsey C.P....Giasson B.I. (Hum. Mol. Genet. 2010)
    281. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. (PubMed id 20457924)9 Hao L.Y....Bonini N.M. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    282. Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. (PubMed id 20046643)9 Yanagida T....Ariga H. (Oxid Med Cell Longev 2009)
    283. Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients. (PubMed id 19497122)9 Nural H....Shen Y. (Mol Neurodegener 2009)
    284. DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders. (PubMed id 17719794)9 Kumaran R....Bandopadhyay R. (Neurobiol. Dis. 2007)
    285. Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons. (PubMed id 16942755)9 Bai Q....Burton E.A. (Brain Res. 2006)
    286. Identification of the epitope of a monoclonal antibody to DJ-1. (PubMed id 15663963)9 Miller D.W....Cookson M.R. (Neurosci. Lett. 2005)
    287. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. (PubMed id 14991385)9 Neumann M....Kahle P.J. (Acta Neuropathol. 2004)
    288. DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity. (PubMed id 20202083)9 Yamashita S....Uchino M. (J. Neurochem. 2010)
    289. DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death. (PubMed id 18309325)9 Mo J.S....Park H.S. (Cell Death Differ. 2008)
    290. DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone. (PubMed id 18930142)9 Mullett S.J. and Hinkle D.A. (Neurobiol. Dis. 2009)
    291. Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease. (PubMed id 19146923)9 Blackinton J....Cookson M.R. (Neurosci. Lett. 2009)
    292. The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. (PubMed id 18003894)9 Aleyasin H....Park D.S. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    293. alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity. (PubMed id 16978583)9 Colapinto M....Fasano M. (Biochem. Biophys. Res. Commun. 2006)
    294. Mutations in DJ-1 are rare in familial Parkinson disease. (PubMed id 16997464)9 Pankratz N....Nichols W.C. (Neurosci. Lett. 2006)
    295. Stimulation of transforming activity of DJ-1 by Abstrakt, a DJ-1-binding protein. (PubMed id 15703824)9 Sekito A....Ariga H. (Int. J. Oncol. 2005)
    296. Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. (PubMed id 15799973)9 Chen L....Zhuang X. (J. Biol. Chem. 2005)
    297. Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. (PubMed id 15081400)9 Kinumi T....Niki E. (Biochem. Biophys. Res. Commun. 2004)
    298. DJ-1 mutations in Parkinson's disease. (PubMed id 14707326)9 Healy D.G....Wood N.W. (J. Neurol. Neurosurg. Psychiatr. 2004)
    299. The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1. (PubMed id 16181642)9 Wilson M.A....Petsko G.A. (J. Mol. Biol. 2005)
    300. [The expression of DJ-1 protein in proteomic analysis of late-onset Alzheimer disease]. (PubMed id 19576113)9 Chen X.H....Liu B.Y. (Zhonghua Nei Ke Za Zhi 2009)
    301. T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease. (PubMed id 17030667)9 Chishti M.A.... Rogaeva E. (Arch. Neurol. 2006)
    302. Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? (PubMed id 15576821)9 Giasson B.I. (Sci Aging Knowledge Environ 2004)
    303. Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease. (PubMed id 19815446)9 Ahlskog J.E. (amp 2009)
    304. Is olfactory impairment in Parkinson disease related to phenotypic or genotypic characteristics? (PubMed id 19047559)9 Verbaan D....van Hilten J.J. (Neurology 2008)
    305. Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease. (PubMed id 17975812)9 Quattrone A....Condino F. (Mov. Disord. 2008)
    306. Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway? (PubMed id 19021753)9 Fitzgerald J.C. and Plun-Favreau H. (FEBS J. 2008)
    307. High-throughput homogeneous mass cleave assay technology for the diagnosis of autosomal recessive Parkinson's disease. (PubMed id 18403612)9 Schroeder C....Bonin M. (J Mol Diagn 2008)
    308. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. (PubMed id 17499497)9 Dodson M.W. and Guo M. (Curr. Opin. Neurobiol. 2007)
    309. Multiplex ligation-dependent probe amplification assay for simultaneous detection of Parkinson's disease gene rearrangements. (PubMed id 17914726)9 Scarciolla O....Dallapiccola B. (Mov. Disord. 2007)
    310. [Molecular genetics of PINK1]. (PubMed id 17713119)9 Funayama M. and Hattori N. (Brain Nerve 2007)
    311. Etiology of Parkinson's disease. (PubMed id 16717248)9 Schapira A.H. (Neurology 2006)
    312. Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. (PubMed id 16439141)9 Betarbet R....Greenamyre J.T. (Neurobiol. Dis. 2006)
    313. The biochemistry of Parkinson's disease. (PubMed id 15952880)9 Cookson M.R. (Annu. Rev. Biochem. 2005)
    314. Genetics of Parkinson's disease. (PubMed id 16175160)9 Bonifati V. (Minerva Med. 2005)
    315. Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study. (PubMed id 15966003)9 Karamohamed S....Myers R.H. (Mov. Disord. 2005)
    316. PET neuroimaging and mutations in the DJ-1 gene. (PubMed id 15565491)9 Dekker M.C....Leenders K.L. (J Neural Transm 2004)
    317. Proteomics-based safety evaluation of multi-walled carbon nanotubes. (PubMed id 19874835)9 Haniu H....Endo M. (Toxicol. Appl. Pharmacol. 2010)
    318. Mitochondrial metabolism modulation: a new therapeutic approach for Parkinson's disease. (PubMed id 20201821)9 ArduA-no D.M....Cardoso S.M. (amp 2010)
    319. Clinical implications of gene discovery in Parkinson's disease and parkinsonism. (PubMed id 20187245)9 Wider C....Wszolek Z.K. (Mov. Disord. 2010)
    320. Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism. (PubMed id 19595762)9 Chu C.T. (Biochim. Biophys. Acta 2010)
    321. Genetic basis of Parkinson disease. (PubMed id 20043722)9 Xiromerisiou G....Hadjigeorgiou G.M. (Neurosurg Focus 2010)
    322. Parkinson's disease: insights from pathways. (PubMed id 20421364)9 Cookson M.R. and Bandmann O. (Hum. Mol. Genet. 2010)
    323. Comment on &quot;compound heterozygosity in DJ-1 gene non-coding portion related to Parkinsonism&quot;. (PubMed id 20227322)9 Sironi F....Goldwurm S. (amp 2010)
    324. Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. (PubMed id 19694908)9 Kitada T....Shen J. (J. Neurochem. 2009)
    325. A role for a novel protein, nucleolin, in Parkinson's disease. (PubMed id 19409963)9 Caudle W.M....Zhang J. (Neurosci. Lett. 2009)
    326. Cell death pathways in Parkinson's disease: role of mitochondria. (PubMed id 19422283)9 Yao Z. and Wood N.W. (amp 2009)
    327. Etiology and pathogenesis of Parkinson disease. (PubMed id 19555823)9 Schapira A.H. (Neurol Clin 2009)
    328. Early involvement of the cerebral cortex in Parkinson's disease: convergence of multiple metabolic defects. (PubMed id 19482226)9 Ferrer I. (Prog. Neurobiol. 2009)
    329. Imaging the impact of genes on Parkinson's disease. (PubMed id 19409223)9 van der Vegt J.P....Siebner H.R. (Neuroscience 2009)
    330. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. (PubMed id 19303005)9 BA1eler H. (Exp. Neurol. 2009)
    331. Molecular pathogenesis of Parkinson disease: insights from genetic studies. (PubMed id 19631006)9 Gasser T. (Expert Rev Mol Med 2009)
    332. Protein degradation in Parkinson disease revisited: it's complex. (PubMed id 19306499)9 Li H. and Guo M. (J. Clin. Invest. 2009)
    333. Parkinson's disease: from monogenic forms to genetic susceptibility factors. (PubMed id 19297401)9 Lesage S. and Brice A. (Hum. Mol. Genet. 2009)
    334. Molecular basis of Parkinson's disease. (PubMed id 19151598)9 Yang Y.X....Latchman D.S. (Neuroreport 2009)
    335. Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. (PubMed id 19563915)9 Dagda R.K....Chu C.T. (Mitochondrion 2009)
    336. Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinson's disease. (PubMed id 20035637)9 Lin T.K....Chuang J.H. (Chang Gung Med J 2009)
    337. From genes to proteins in mendelian Parkinson's disease: an overview. (PubMed id 19943343)9 Pirkevi C....BaA9ak A.N. (Anat Rec (Hoboken) 2009)
    338. Complicated recessive dystonia parkinsonism syndromes. (PubMed id 19185014)9 Schneider S.A....Hardy J. (Mov. Disord. 2009)
    339. The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics. (PubMed id 19703660)9 Thomas K.J. and Cookson M.R. (amp 2009)
    340. Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease. (PubMed id 19156451)9 GonzA!lez-PAcrez A....Ruiz A. (Neurogenetics 2009)
    341. Is there a pathogenic role for mitochondria in Parkinson's disease? (PubMed id 20083000)9 Vives-Bauza C....Przedborski S. (amp 2009)
    342. Neurodegeneration in Parkinson's disease: genetics enlightens physiopathology. (PubMed id 20411780)9 Corti O....Brice A. (J. Neural Transm. Suppl. 2009)
    343. Transgenic rodent models of Parkinson's disease. (PubMed id 18642640)9 Harvey B.K....Hoffer B.J. (Acta Neurochir. Suppl. 2008)
    344. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. (PubMed id 18978800)9 Henchcliffe C. and Beal M.F. (Nat Clin Pract Neurol 2008)
    345. Proteomic analysis of cervical cancer cells treated with adenovirus-mediated MDA-7. (PubMed id 18299662)9 Wei L....Song F. (amp 2008)
    346. Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? (PubMed id 17680806)9 Bogaerts V....van Broeckhoven C. (Genes Brain Behav. 2008)
    347. Structure of the stress response protein DR1199 from Deinococcus radiodurans: a member of the DJ-1 superfamily. (PubMed id 18850720)9 Fioravanti E....McSweeney S. (Biochemistry 2008)
    348. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. (PubMed id 18093566)9 Schapira A.H. (Lancet Neurol 2008)
    349. On the pathogenesis and neuroprotective treatment of Parkinson disease: what have we learned from the genetic forms of this disease? (PubMed id 18855661)9 Mena Yebenes J.G. (Curr. Med. Chem. 2008)
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    351. Programmed cell death and new discoveries in the genetics of parkinsonism. (PubMed id 17996022)9 Burke R.E. (J. Neurochem. 2008)
    352. Overexpression of calcineurin B subunit (CnB) enhances the oncogenic potential of HEK293 cells. (PubMed id 18422742)9 Wang Y.L....Wei Q. (Cancer Sci. 2008)
    353. Proteome analysis of human substantia nigra in Parkinson's disease. (PubMed id 18275612)9 Werner C.J....Wolf S. (Proteome Sci 2008)
    354. Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism. (PubMed id 19087301)9 Myhre R....Klungland H. (BMC Neurol 2008)
    355. Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. (PubMed id 18759352)9 Tomiyama H....Kuzuhara S. (Mov. Disord. 2008)
    356. Update on the pathogenesis of Parkinson's disease. (PubMed id 18787877)9 Schulz J.B. (J. Neurol. 2008)
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    Entrez Gene: 11315 HGNC: 16369 AceView: PARK7 Ensembl:ENSG00000116288 euGenes: HUgn11315
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway and/or Taconic Biosciences,
    CRISPR knockouts from OriGene)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of PARK7
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     Antibodies for PARK7 (Park7/DJ-1)   Browse Cell Culture Products  
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     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PARK7   OriGene RNAi products in human, mouse, rat for PARK7  
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     OriGene qSTAR qPCR primer pairs in human, mouse for PARK7   OriGene Purified Protein for PARK7  
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     OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling   OriGene Custom Antibody Services for PARK7  
     OriGene Custom Protein Services for PARK7  

     Block miRNA regulation of human, mouse, rat PARK7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PARK7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARK7 Predesigned siRNA for gene silencing in human, mouse, rat PARK7
     QuantiFast Probe-based Assays in human, mouse, rat PARK7 QuantiTect SYBR Green Assays in human, mouse, rat PARK7
     PCR Arrays including human, mouse, rat PARK7 Search Chromatin IP Primers for PARK7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARK7  GeneGlobe Interaction Network for PARK7
     Regulatory tfbs in PARK7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PARK7 GenScript cDNA clones with any tag delivered in your preferred vector for PARK7
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     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Antibodies & Assays for PARK7  (DJ-1)

     Search Tocris compounds for PARK7
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     Browse Sino Biological Cell Lysates
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for PARK7
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     Abcam protocols and scientific support
     Recombinant Protein for PARK7
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PARK7
      Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7
     SwitchGear 3'UTR luciferase reporter plasmids for PARK7
     SwitchGear Promoter luciferase reporter plasmids for PARK7
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARK7
     Browse compounds at ApexBio
     Addgene plasmids for PARK7
      Search eBioscience for proteins for PARK7
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PARK7
     antibodies-online antibodies for PARK7 (175 products)
     antibodies-online kits for PARK7 (12 products)
     antibodies-online peptides for PARK7
     antibodies-online proteins for PARK7 (26 products)
      GeneTex Antibodies for PARK7: PARK7 Antibodies
      Search GeneTex for Proteins for PARK7
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