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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PARK7 Gene

protein-coding   GIFtS: 67
GCID: GC01P007944

parkinson protein 7

(Previous names: Parkinson disease (autosomal recessive, early onset) 7...)
 Explore 65 diseases affiliated with
PARK7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PARK7    

Aliases
for PARK7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Parkinson Protein 71 2     Oncogene DJ12 3
DJ11 2 5     Protein DJ-12
DJ-11 2     EC 3.4.-.-3
Parkinson Disease (Autosomal Recessive, Early Onset) 71 2     Parkinson Disease Protein 73

External Ids:    HGNC: 163691   Entrez Gene: 113152   Ensembl: ENSG000001162887   OMIM: 6025335   UniProtKB: Q994973   

Export aliases for PARK7 gene to outside databases

Previous GC identifers: GC01U990455 GC01P007830 GC01P007618 GC01P007731 GC01P007956 GC01P007169


Summaries
for PARK7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PARK7:
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen
receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative
stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause
of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been
identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of
the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars
compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during
pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as
an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide,
displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes
NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its
deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies
of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for
correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte
inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents
aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity
and transforming activity. May function as a redox-sensitive chaperone

Gene Wiki entry for PARK7


Genomic Views
for PARK7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PARK7 gene promoter:
         PPAR-gamma1   POU2F1   SREBP-1a   AML1a   POU2F1a   SREBP-1c   PPAR-gamma2   Pax-4a   SREBP-1b   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PARK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PARK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

PARK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P007944:  view genomic region     (about GC identifiers)

Start:
 8,014,351 bp from pter      End:
 8,045,565 bp from pter
Size:
 31,215 bases      Orientation:
 plus strand

Proteins
for PARK7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497 (See protein sequence)
Recommended Name: Protein DJ-1 precursor  
Size: 189 amino acids; 19891 Da
Subunit: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.
Interacts (via N-terminus) with OTUD7B. Interacts with BBS1, HIPK1, CLCF1 and MTERF
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Under normal conditions, located predominantly in the
cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and
subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against
oxidative damage. Detected in tau inclusions in brains from neurodegenerative disease patients
6/26 PDB 3D structures from and Proteopedia for PARK7 (see all 26):
1J42 (3D)        1P5F (3D)        1PDV (3D)        1PDW (3D)        1PE0 (3D)        1Q2U (3D)    
Secondary accessions: B2R4Z1 O14805 Q6DR95 Q7LFU2

Explore the universe of human proteins at neXtProt for PARK7: NX_Q99497

Post-translational modifications:

  • Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for cell-growth
    • promoting activity and transforming activity1
  • Cys-106 is easily oxidized to sulfinic acid1
  • Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative
    • stress1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99497

    • PARK7 Protein expression data from MOPED and PaxDb:    About this image 
    PARK7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116849.1  NP_009193.2  

    ENSEMBL proteins: 
     ENSP00000465404   ENSP00000340278   ENSP00000418770   ENSP00000466242   ENSP00000366711  
     ENSP00000366708   ENSP00000466756  

    Human Recombinant Protein Products for PARK7: 
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    OriGene Purified Proteins (see all 2): PARK7
    OriGene Protein Over-expression Lysate (see all 2): PARK7
    OriGene Custom Protein Services for PARK7 
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    Novus Biologicals PARK7 Proteins
    Novus Biologicals PARK7 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PARK7
    Uscn Proteins for PARK7

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12446870
    GO:0005737cytoplasm IDA12446870
    GO:0005739mitochondrion IDA18711745
    GO:0005829cytosol ----
    GO:0030424axon ----

    PARK7 for ontologies           About GeneDecksing



    PARK7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARK7
    R&D Systems Antibodies for PARK7 (Park7/DJ-1)
    Cell Signaling Technology (CST) Antibodies for PARK7  (DJ-1)
    OriGene Antibodies (see all 5): PARK7
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    Novus Biologicals PARK7 Antibodies
    Abcam antibodies for PARK7 
    Uscn Antibodies for PARK7
    ThermoFisher Antibody for PARK7

    Assay Products for PARK7: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PARK7

    Protein Domains /
    Families
    for PARK7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PARK7 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006287 DJ1
     IPR002818 ThiJ/PfpI

    Graphical View of Domain Structure for InterPro Entry Q99497

    ProtoNet protein and cluster: Q99497

    1 Blocks protein family: IPB002818 Family of unknown function ThiJ/PfpI

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Similarity: Belongs to the peptidase C56 family


    Function
    for PARK7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARK7_HUMAN, Q99497
    Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of
    the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars
    compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during
    pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as
    an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide,
    displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes
    NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its
    deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies
    of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for
    correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte
    inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents
    aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity
    and transforming activity. May function as a redox-sensitive chaperone
    Biophysicochemical properties: Kinetic parameters: KM=173.4 uM for casein;
    Induction: By hydrogen peroxide and UV irradiation

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA18626009
    GO:0004601peroxidase activity ISS--
    GO:0005515protein binding IPI--
    GO:0008233peptidase activity IDA--
    GO:0042803protein homodimerization activity IDA18711745
         
    PARK7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PARK7:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Park7):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  nervous system 

    PARK7 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for PARK7: Park7tm1Cai Park7tm1Tmd Park7tm1Xz Park7tm1Shn Park7tm1Dsp
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PARK7 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PARK7
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    SwitchGear 3'UTR luciferase reporter plasmid: PARK7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PARK7 (see all 7)
    OriGene shRNA RFP: PARK7
    OriGene siRNA: PARK7
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    Sirion Biotech Custom design and validation of potent shRNA sequences against PARK7 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PARK7 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PARK7 (see all 4)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PARK7 (NM_007262)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for PARK7
    Sirion Biotech Customized stable knockdown cell line services for PARK7 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7


    Pathways & Interactions
    for PARK7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2PI3K / Akt Signaling
    		PI3K / Akt Signaling1.00
    3Parkinsons Disease Pathway
    		Parkinsons Disease Pathway1.00
    4Synaptic Vesicle Pathway
    		Synaptic Vesicle Pathway1.00
    5Alpha-synuclein signaling
    		Alpha-synuclein signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PARK7
        Parkinson's Disease Pathway

    2 Cell Signaling Technology (CST) Pathways for PARK7
        Neuroscience
    PI3K / Akt Signaling

    4 BioSystems Pathways for PARK7 
        Parkinsons Disease Pathway
    Synaptic Vesicle Pathway
    Androgen receptor signaling pathway
    Alpha-synuclein signaling


    1         Kegg Pathway  (Kegg details for PARK7):
        Parkinson's disease


    PARK7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PARK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/69 Interacting proteins for PARK7 (Q994971, 2, 3 ENSP000003402784) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTA2O947761, 3, ENSP000002788234EBI-1164361,EBI-1783035 I2D: score=2 STRING: ENSP00000278823
    OTUD7BQ6GQQ91, 3, ENSP000003581314EBI-1164361,EBI-527784 I2D: score=2 STRING: ENSP00000358131
    ARP102751, 3, ENSP000003638224EBI-1164361,EBI-608057 I2D: score=1 STRING: ENSP00000363822
    DAXXQ9UER71, 3, ENSP000003968764EBI-1164361,EBI-77321 I2D: score=2 STRING: ENSP00000396876 STRING: ENSP00000266000
    PPP2R1AP301533, ENSP000003248044I2D: score=3 STRING: ENSP00000324804
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ----
    GO:0006508proteolysis IEA--
    GO:0006914autophagy IEA--
    GO:0006950response to stress ----
    GO:0006954inflammatory response IEA--

    PARK7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PARK7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PARK7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PARK7

    1 DrugBank Compound for PARK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Double Oxidized Cysteine-- --target--17139284 17016423

    10/17 Novoseek chemical compound relationships for PARK7 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    e 64d 76.3 9 15365989 (3), 17451229 (1), 20186336 (1), 15663963 (1)
    sulfinic acid 59.7 3 16403519 (2), 16181642 (1)
    rotenone 56 8 18377993 (3), 16439141 (2), 16854843 (2), 18930142 (1)
    6-hydroxydopamine 51.9 8 18377993 (3), 18974921 (1), 16860563 (1), 16227205 (1) (see all 5)
    dopamine 46.9 33 16978583 (4), 18974921 (4), 19703902 (3), 16227205 (2) (see all 9)
    cysteine 34.6 35 16316629 (3), 19124468 (2), 16935423 (2), 18570440 (2) (see all 13)
    h2o2 30.8 20 16935423 (2), 15081400 (2), 20046643 (2), 14652021 (1) (see all 10)
    levodopa 29.9 1 19703902 (1)
    oxygen 17.5 13 16403519 (1), 16115732 (1), 18430896 (1), 15219840 (1) (see all 12)
    pyrimidine 14.5 4 16731528 (2), 15790595 (1), 18689799 (1)

    Search CenterWatch for drugs/clinical trials and news about PARK7 

    Transcripts
    for PARK7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PARK7 gene (2 alternative transcripts): 
    NM_001123377.1  NM_007262.4  

    Unigene Cluster for PARK7:

    Parkinson protein 7
    Hs.419640  [show with all ESTs]
    Unigene Representative Sequence: BF965121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493373 ENST00000460192 ENST00000338639(uc001aou.4 uc001aox.4 uc001aov.4)
    ENST00000493678 ENST00000377493 ENST00000465354 ENST00000377491 ENST00000377488
    ENST00000497113 ENST00000469225

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    Inhib. RNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against PARK7 
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB073864.1 AF021819.1 AK130886.1 AK312000.1 BC008188.2 D61380.2 

    24/30 DOTS entries (see all 30):

    DT.100864956  DT.448826  DT.91912005  DT.100864954  DT.100864946  DT.99944190  DT.91858715  DT.100723157 
    DT.121340910  DT.95171052  DT.100864949  DT.100864951  DT.100864952  DT.95171053  DT.91717622  DT.95171037 
    DT.100864945  DT.100864955  DT.121340885  DT.121340900  DT.121340908  DT.121340933  DT.121340949  DT.91778970 

    24/818 AceView cDNA sequences (see all 818):

    BM760096 BM760893 BU167723 D61380 BQ436114 AI174859 BM792160 AV704886 
    CD047909 BE550383 BM712090 AK091679 BG113506 BQ643180 BI085219 AX747125 
    BU533141 T34178 AA315511 BM771936 BI830621 BU159556 BM908816 AI042422 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PARK7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -     -     -     -                                         -     -                                 
    SP2:                          -     -     -                                         -     -                                 
    SP3:                                                                                -     -                                 
    SP4:                    -     -     -     -                 -     -                 -     -                                 
    SP5:                                      -                                         -     -                                 


    ECgene alternative splicing isoforms for PARK7

    Expression
    for PARK7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATAGGTTT
    PARK7 Expression
    About this image
    See PARK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PARK7

    SOURCE GeneReport for Unigene cluster: Hs.419640

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at
    slightly lower levels in placenta and brain. Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and
    spermatozoa

        SABiosciences Expression via Pathway-Focused PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PARK7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PARK7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PARK7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PARK7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7

    Orthologs
    for PARK7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for PARK7 gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Park71 , 5 Parkinson disease (autosomal recessive, early onset) more1, 5 84.3(n)1
    91.53(a)1    		   4 (81.52 cM)5
    573201  NM_020569.31  NP_065594.21 
     1508971335 
    chicken
    (Gallus gallus)    		 Aves PARK71 Parkinson disease (autosomal recessive, early onset) more 79.37(n)
    89.95(a)    		   395277  NM_204585.1  NP_989916.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PARK76
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL344178.1(17994-24625)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.114132 Xenopus laevis SP22 mRNA, complete cds 77.13(n)    AF394958.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.155302 Transcribed sequence with moderate similarity to protein more 74.28(n)    BM317196.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta DJ-1alpha1 CG6646-PA 54.8(n)
    57.06(a)    		   36543  NM_137072.1  NP_610916.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea djr-1.11 Protein DJR-1.1 57.3(n)
    54.05(a)    		   173416  NM_061295.5  NP_493696.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G149906
    AT1G532806
    (see all 3)    		 class I glutamine amidotransferase domain-containi...
    4-methyl-5(b-hydroxyethyl)-thiazole monophosphate ...
    (see all 3)    		 17(a)
    16(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 3(5047400-5049877)
    1(19864770-19867389)
    rice
    (Oryza sativa)    		 Liliopsida Os01g02178001 hypothetical protein 47.99(n)
    39.56(a)    		   4324581  NM_001048942.1  NP_001042407.2 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yajL6
    		 Oxidative-stress-resistance chaperone
    		 39(a)
    		 1 ↔ 1
    		 Chromosome(442275-442865)


    ENSEMBL Gene Tree for PARK7 (if available)
    TreeFam Gene Tree for PARK7 (if available) 

    Paralogs
    for PARK7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PARK7 gene

    PARK7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PARK7
    PGOHUM00000239770 PGOHUM00000236716


    Genomic Variants
    for PARK7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/470 NCBI SNPs in PARK7 are shown (see all 470)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs743153511,2
    		Cpathogenic8022923(+) GTCATA/GAGGCG 4 I M mis10--------
    rs743153521,2
    		C,Fpathogenic8044990(+) AAAAGA/CCGGCC 4 D A mis11Minor allele frequency- C:0.00NA 4552
    rs1859284181,2
    		--8019720(+) CCACTA/GTGGAA 2 -- us2k10--------
    rs1906380831,2
    		--8020015(+) CTCGAA/GAGACT 2 -- us2k10--------
    rs115772391,2
    		C,F,H--8020162(+) AGATAT/CTTGCA 2 -- us2k11Minor allele frequency- C:0.33NA 6
    rs1497936191,2
    		--8020510(+) TTGGTA/TGAAGT 2 -- us2k10--------
    rs1475170511,2
    		--8020526(+) GCAAGG/TTGTCA 2 -- us2k10--------
    rs1813171161,2
    		--8020636(+) CAGAAA/GAGTGC 2 -- us2k10--------
    rs1865107631,2
    		--8020707(+) TCTCAC/TTTTTT 2 -- us2k10--------
    rs1400791281,2
    		--8020833(+) AATAGA/GGATAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARK7 (8014351 - 8045565 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PARK7: --
    Human Gene Mutation Database (HGMD): PARK7

    Locus Specific Mutation Databases (LSDB): PARK7

    1 SABiosciences Cancer Mutation PCR Assay for PARK7:
    Cosmic IdAA Change
    98000118
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PARK7
    DNA2.0 Custom Variant and Variant Library Synthesis for PARK7

    Disorders / Diseases
    for PARK7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PARK7 for disorders           About GeneDecksing

    OMIM gene information: 602533   
    OMIM disorders: 606324  
    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
  • Defects in PARK7 are the cause of Parkinson disease type 7 (PARK7) [MIM:606324]. A neurodegenerative disorder
    • characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes.
    PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits
    reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease)

    20/65 diseases for PARK7 (see all 65):    About MalaCards
    parkinson's disease    parkinson disease 7, autosomal recessive early-onset    amyotrophic lateral sclerosis-parkinsonism/dementia complex 2    spinocerebellar ataxia type 17
    inclusion body myositis    supranuclear palsy    amyotrophic lateral sclerosis    clear cell renal cell carcinoma
    spinocerebellar ataxia    lateral sclerosis    parkinson disease 10    squamous cell carcinoma
    chronic obstructive pulmonary disease    laryngeal squamous cell carcinoma    short stature    multiple system atrophy
    tauopathy    esophageal squamous cell carcinoma    renal cell carcinoma    pancreatic ductal adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for PARK7:
    Parkinson's disease

    10/20 Novoseek disease relationships for PARK7 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 89.2 181 20157014 (6), 14662519 (5), 15219840 (4), 14707326 (3) (see all 99)
    autosomal recessive parkinsonism 87.5 12 14638971 (3), 19429112 (2), 17914725 (1), 19297401 (1) (see all 7)
    parkinsonism 85.4 87 19429112 (5), 15565491 (2), 19124468 (2), 15542239 (2) (see all 47)
    parkinsonism juvenile autosomal recessive 81 10 14652021 (1), 14745011 (1), 17268184 (1), 19243613 (1) (see all 8)
    parkinson disease, autosomal dominant 76.4 2 15717024 (1)
    neurodegenerative diseases 74.9 18 19686841 (2), 14705119 (2), 17719794 (2), 18930142 (1) (see all 12)
    neurodegeneration 65.1 11 14712351 (2), 19023331 (1), 16115732 (1), 16439141 (1) (see all 9)
    movement disorders 64 1 18704525 (1)
    tauopathies 57.9 8 14991385 (2), 15935068 (1), 17085780 (1), 14705119 (1)
    lewy body disease 38.6 1 14625045 (1)

    GeneTests: PARK7
    Parkinson Disease

    Genetic Association Database (GAD): PARK7
    Human Genome Epidemiology (HuGE) Navigator: PARK7 (24 documents)

    Export disorders for PARK7 gene to outside databases

    Publications
    for PARK7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARK7 gene, integrated from 9 sources (see all 388) (see top 10):
    (articles sorted by number of sources associating them with PARK7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. (PubMed id 14872018)1, 2, 4, 9 Hedrich K.... Klein C. (2004)
    2. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. (PubMed id 9070310)1, 2, 3, 9 Nagakubo D.... Ariga H. (1997)
    3. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. (PubMed id 18711745)1, 2, 9 Junn E....Mouradian M.M. (2009)
    4. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. (PubMed id 14662519)1, 2, 9 Bandopadhyay R.... Lees A.J. (2004)
    5. DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. (PubMed id 16390825)1, 2, 9 Sekito A....Ariga H. (2006)
    6. The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. (PubMed id 12855764)1, 2, 9 Wilson M.A.... Petsko G.A. (2003)
    7. A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo- oligomerization. (PubMed id 14713311)1, 2, 9 Moore D.J.... Dawson V.L. (2003)
    8. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. (PubMed id 12914946)1, 2, 9 Huai Q.... Ke H. (2003)
    9. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. (PubMed id 11223268)1, 2, 9 Taira T.... Ariga H. (2001)
    10. The role of pathogenic DJ-1 mutations in Parkinson's disease. (PubMed id 12953260)1, 2, 9 Abou-Sleiman P.M.... Wood N.W. (2003)
    11. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. (PubMed id 11477070)1, 2, 9 Takahashi K....Ariga H. (2001)
    12. Reduced basal autophagy and impaired mitochondrial dy namics due to loss of Parkinson's disease-associated protein DJ-1. (PubMed id 20186336)1, 2, 9 Krebiehl G....KrA1ger R. (2010)
    13. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. (PubMed id 18626009)1, 2, 9 van der Brug M.P....Cookson M.R. (2008)
    14. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. (PubMed id 17015834)1, 2, 9 Clements C.M....Ting J.P. (2006)
    15. Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity. (PubMed id 15308309)1, 4, 9 Tan E.K....Wong M.C. (2004)
    16. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. (PubMed id 15181200)1, 2, 9 Canet-Aviles R.M.... Cookson M.R. (2004)
    17. Detection of Parkin (PARK2) and DJ1 (PARK7) mutations in early-onset Parkinson disease: Parkin mutation frequency depends on ethnic origin of patients. (PubMed id 15108293)1, 4, 9 Djarmati A....Kostic V. (2004)
    18. Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism. (PubMed id 15372597)1, 4, 9 Lockhart P.J....Farrer M.J. (2004)
    19. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. (PubMed id 17846173)1, 2, 9 Olzmann J.A....Chin L.S. (2007)
    20. Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. (PubMed id 14607841)1, 2, 9 Goerner K.... Kahle P.J. (2004)
    21. Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. (PubMed id 12761214)1, 2, 9 Tao X. and Tong L. (2003)
    22. PINK1, Parkin, and DJ-1 mutations in Italian patients with early- onset parkinsonism. (PubMed id 15970950)1, 4, 9 Klein C.... Pramstaller P.P. (2005)
    23. Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). (PubMed id 15365989)1, 2, 9 Hering R....Riess O. (2004)
    24. A deletion in DJ-1 and the risk of dementia--a population-based survey. (PubMed id 15542239)1, 4, 9 Arias Vasquez A....van Duijn C.M. (2004)
    25. Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations. (PubMed id 15254937)1, 2, 9 Clark L.N....Marder K. (2004)
    26. A limited role for DJ1 in Parkinson disease susceptibility. (PubMed id 15304593)1, 4, 9 Maraganore D.M....Farrer M.J. (2004)
    27. DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia. (PubMed id 14705119)1, 2, 9 Rizzu P.... Heutink P. (2004)
    28. Mutations in the DJ-1 gene associated with autosomal recessive early- onset Parkinsonism. (PubMed id 12446870)1, 2, 9 Bonifati V.... Heutink P. (2003)
    29. L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. (PubMed id 12851414)1, 2, 9 Miller D.W.... Cookson M.R. (2003)
    30. DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex. (PubMed id 16240358)1, 2, 9 Annesi G....Quattrone A. (2005)
    31. Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD. (PubMed id 14557580)1, 4, 9 Eerola J....Singleton A.B. (2003)
    32. DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. (PubMed id 21097510)1, 2 McNally R.S.... Ting J.P. (2010)
    33. Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. (PubMed id 20304780)1, 2 Chen J.... Chin L.S. (2010)
    34. Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. (PubMed id 15976810)1, 2 Shinbo Y.... Ariga H. (2006)
    35. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    36. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    37. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    38. DJ-1 has a role in antioxidative stress to prevent cell death. (PubMed id 14749723)1, 2 Taira T....Ariga H. (2004)
    39. The R98Q variation in DJ-1 represents a rare polymorphism. (PubMed id 14705128)1, 2 Hedrich K....Klein C. (2004)
    40. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha- synuclein aggregate formation. (PubMed id 15502874)1, 2 Shendelman S.... Abeliovich A. (2004)
    41. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    42. The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. (PubMed id 12796482)1, 2 Honbou K....Inagaki F. (2003)
    43. Immunocytochemical localization of DJ-1 in human male reproductive tissue. (PubMed id 14579415)1, 2 Yoshida K.... Iwamoto T. (2003)
    44. Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. (PubMed id 12939276)1, 2 Lee S.-J.... Cha S.-S. (2003)
    45. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. (PubMed id 12612053)1, 2 Niki T.... Ariga H. (2003)
    46. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. (PubMed id 11462174)1, 3 van Duijn C.M....Heutink P. (2001)
    47. Oxidation of DJ-1-dependent cell transformation throu gh direct binding of DJ-1 to PTEN. (PubMed id 19885556)1, 9 Kim Y.C....Ariga H. (2009)
    48. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. (PubMed id 15944198)1, 9 Zhang L....Dawson V.L. (2005)
    49. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. (PubMed id 16227205)1, 9 Zhou W. and Freed C.R. (2005)
    50. DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age. (PubMed id 18647263)1, 9 Mullett S.J....Hinkle D.A. (2009)
    51. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. (PubMed id 15525661)1, 9 Moore D.J....Dawson V.L. (2005)
    52. DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. (PubMed id 16731528)1, 9 Zhong N....Xu J. (2006)
    53. Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. (PubMed id 17120294)1, 9 Olzmann J.A....Chin L.S. (2007)
    54. Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis. (PubMed id 17034344)1, 9 Lev N....Offen D. (2006)
    55. Oxidative status of DJ-1-dependent activation of dopa mine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-ph enylalanine (L-DOPA) decarboxylase with DJ-1. (PubMed id 19703902)1, 9 Ishikawa S....Iguchi-Ariga S.M. (2009)
    56. DJ-1 protects against dopamine toxicity. (PubMed id 18974921)1, 9 Lev N....Offen D. (2009)
    57. Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells. (PubMed id 18430896)1, 9 Zhang H.Y....Du Z.X. (2008)
    58. Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation. (PubMed id 18689799)1, 9 Zhong N. and Xu J. (2008)
    59. DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. (PubMed id 19064576)1, 9 Yuen H.F....Chan K.W. (2008)
    60. DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. (PubMed id 17487420)1, 9 Koide-Yoshida S....Ariga H. (2007)
    61. DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents. (PubMed id 17599367)1, 9 Galter D....Olson L. (2007)
    62. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. (PubMed id 16517609)1, 9 Choi J....Li L. (2006)
    63. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. (PubMed id 16403519)1, 9 Zhou W....Fink A.L. (2006)
    64. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. (PubMed id 15935068)1, 9 Meulener M.C....Giasson B.I. (2005)
    65. Increased interaction between DJ-1 and the Mi-2/ nucl eosome remodelling and deacetylase complex during cellular stress. (PubMed id 20127688)1, 9 Opsahl J.A....Fladmark K.E. (2010)
    66. Loss of function of DJ-1 triggered by Parkinson's dis ease-associated mutation is due to proteolytic resistance to caspase-6. (PubMed id 19680261)1, 9 Giaime E....Alves da Costa C. (2010)
    67. DJ-1 and prevention of oxidative stress in Parkinson' s disease and other age-related disorders. (PubMed id 19686841)1, 9 Kahle P.J....Gasser T. (2009)
    68. Proteomic analysis of oxidative stress-responsive proteins in human pneumocytes: insight into the regulation of DJ-1 expression. (PubMed id 18817430)1, 9 Duan X....Merali S. (2008)
    69. Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma. (PubMed id 17949781)1, 9 Davidson B....Reich R. (2008)
    70. Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease. (PubMed id 17451229)1, 9 Hulleman J.D....Rochet J.C. (2007)
    71. Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. (PubMed id 14665635)1, 9 Olzmann J.A....Chin L.S. (2004)
    72. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. (PubMed id 14652021)1, 9 Yokota T....Mizusawa H. (2003)
    73. Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene. (PubMed id 19825160)1, 9 Keyser R.J....Bardien S. (2009)
    74. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. (PubMed id 18042550)1, 9 Fan J....Wang G. (2008)
    75. DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70. (PubMed id 18382667)1, 9 Batelli S....Forloni G. (2008)
    76. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. (PubMed id 15790595)1, 9 Xu J....Yankner B.A. (2005)
    77. Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism. (PubMed id 19429112)1, 9 Tomiyama H....Hattori N. (2009)
    78. DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. (PubMed id 19144925)1, 9 Vasseur S....Mak T.W. (2009)
    79. Differential DJ-1 gene expression in Parkinson's dise ase. (PubMed id 19716892)1, 9 Kumaran R....Bandopadhyay R. (2009)
    80. Expression and role of DJ-1 in leukemia. (PubMed id 18722352)1, 9 Liu H....Wang J. (2008)
    81. DJ-1: a newcomer in Parkinson's disease pathology. (PubMed id 18045143)1, 9 da Costa C.A. (2007)
    82. Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. (PubMed id 15219840)1, 9 Takahashi-Niki K....Ariga H. (2004)
    83. Prognostic significance of nuclear DJ-1 expression in astrocytoma. (PubMed id 20150646)1, 9 Miyajima Y....Fujii K. (2010)
    84. DJ-1 modulates the p38 mitogen-activated protein kina se pathway through physical interaction with apoptosis signal-regulating kinase 1. (PubMed id 20213747)1, 9 Mo J.S....Park H.S. (2010)
    85. BAG1 restores formation of functional DJ-1 L166P dime rs and DJ-1 chaperone activity. (PubMed id 20156966)1, 9 Deeg S....Kermer P. (2010)
    86. Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. (PubMed id 19124468)1, 9 Blackinton J....Wilson M.A. (2009)
    87. The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma. (PubMed id 19384955)1, 9 Sitaram R.T....Roos G. (2009)
    88. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. (PubMed id 19229105)1, 9 Xiong H....Zhang Z. (2009)
    89. Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. (PubMed id 18706098)1, 9 Tian M....Han J.X. (2008)
    90. Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism. (PubMed id 18785233)1, 9 Guo J.F....Tang B.S. (2008)
    91. DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. (PubMed id 17510388)1, 9 Tillman J.E....Kasper S. (2007)
    92. Association of PINK1 and DJ-1 confers digenic inheritance of early- onset Parkinson's disease. (PubMed id 16632486)1, 9 Tang B.... Zhang Z. (2006)
    93. Role of DJ-1 in Parkinson's disease. (PubMed id 17085780)1, 9 Lev N....Offen D. (2006)
    94. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. (PubMed id 15983381)1, 9 Junn E....Mouradian M.M. (2005)
    95. DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. (PubMed id 15703819)1, 9 Shinbo Y....Ariga H. (2005)
    96. DJ-1, a novel regulator of the tumor suppressor PTEN. (PubMed id 15766664)1, 9 Kim R.H....Mak T.W. (2005)
    97. Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. (PubMed id 18922803)1, 9 Cha S.S....Kang S.O. (2008)
    98. DJ-1 is a Parkinson's disease susceptibility gene in southern Italy. (PubMed id 19968671)1, 9 De Marco E.V....Quattrone A. (2010)
    99. Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease. (PubMed id 18973254)1, 9 Macedo M.G....Heutink P. (2008)
    100. Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. (PubMed id 16316629)1, 9 Ito G....Iwatsubo T. (2006)
    101. Screening for DJ-1 mutations in early onset autosomal recessive parkinsonism. (PubMed id 14638971)1, 9 Ibanez P....Brice A. (2003)
    102. Leucine-Rich Repeat Kinase 2 interacts with Parkin, D J-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. (PubMed id 19692353)1, 9 Venderova K....Park D.S. (2009)
    103. [Association of the DJ-1 gene polymorphism with sporadic Parkinson's disease in Sichuan province of China] (PubMed id 18841573)1, 9 Chen W....Jiang Q. (2008)
    104. Genotype-phenotype correlates in Taiwanese patients with early-onset recessive parkinsonism. (PubMed id 19006224)1, 9 Lee M.J....Wu R.M. (2008)
    105. Cysteine pKa depression by a protonated glutamic acid in human DJ-1. (PubMed id 18570440)1, 9 Witt A.C....Wilson M.A. (2008)
    106. Structural effects of Parkinson's disease linked DJ-1 mutations. (PubMed id 18436956)1, 9 Malgieri G. and Eliezer D. (2008)
    107. Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease. (PubMed id 18704525)1, 9 Choi J.M....Kim Y.J. (2008)
    108. On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study. (PubMed id 17504761)1, 9 Herrera F.E....Carloni P. (2007)
    109. The Arabidopsis DJ-1a protein confers stress protecti on through cytosolic SOD activation. (PubMed id 20406884)1, 9 Xu X.M....ller S.G. (2010)
    110. Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations. (PubMed id 19023331)1, 9 Zucchelli S....Gustincich S. (2009)
    111. Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population. (PubMed id 19405094)1, 9 Nuytemans K....Theuns J. (2009)
    112. Silencing DJ-1 reveals its contribution in paraquat-induced autophagy. (PubMed id 19425177)1, 9 GonzA!lez-Polo R....Fuentes J.M. (2009)
    113. The E163K DJ-1 mutant shows specific antioxidant defi ciency. (PubMed id 18822273)1, 9 Ramsey C.P. and Giasson B.I. (2008)
    114. Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism. (PubMed id 18722801)1, 9 Tarantino P....Quattrone A. (2008)
    115. Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia. (PubMed id 18486522)1, 9 Mellick G.D....Hattori N. (2008)
    116. LRRK2 gene in Parkinson disease: mutation analysis and case control association study. (PubMed id 16157901)1, 9 Paisan-Ruiz C....Rogaeva E. (2005)
    117. Genetics of Parkinson disease. (PubMed id 15717024)1, 9 Pankratz N. and Foroud T. (2004)
    118. Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. (PubMed id 14712351)1, 9 Bonifati V....Heutink P. (2004)
    119. DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function. (PubMed id 14985393)1, 9 Lockhart P.J....Farrer M.J. (2004)
    120. Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease. (PubMed id 14625045)1, 9 Morris C.M....Singleton A.B. (2003)
    121. DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism. (PubMed id 14598065)1, 9 Bonifati V....Heutink P. (2003)
    122. A clinical-genetic study of Parkinson's disease in a genetically isolated community. (PubMed id 14504966)4, 9 Dekker M.C....van Duijn C.M. (2003)
    123. Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7. (PubMed id 12548343)1, 9 Bonifati V....Heutink P. (2002)
    124. Peroxiredoxins and their expression in ependymomas. (PubMed id 23076395)1 Haapasalo T....Soini Y. (2013)
    125. Oxidized DJ-1 inhibits p53 by sequestering p53 from pr omoters in a DNA-binding affinity-dependent manner. (PubMed id 23149933)1 Kato I....Ariga H. (2013)
    126. DJ-1 upregulates tyrosine hydroxylase gene expression by activating its transcriptional factor Nurr1 via the ERK1/2 pathway. (PubMed id 22024154)1 Lu L....Yang H. (2012)
    127. Parkinson's disease-associated DJ-1 mutations impair m itochondrial dynamics and cause mitochondrial dysfunction. (PubMed id 22428580)1 Wang X....Zhu X. (2012)
    128. Nuclear factor erythroid-derived 2-like 2 (Nrf2) and D J1 are prognostic factors in lung cancer. (PubMed id 21943684)1 Merikallio H....Soini Y. (2012)
    129. Genetic bases and phenotypes of autosomal recessive Pa rkinson disease in a Turkish population. (PubMed id 22233331)1 Lohmann E....Emre M. (2012)
    130. Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation. (PubMed id 22571429)1 Chen C.Y. (2012)
    131. Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. (PubMed id 22666465)1 Yamaguchi S....Ariga H. (2012)
    132. Biochemical premotor biomarkers for Parkinson's disease. (PubMed id 22508282)1 Mollenhauer B. and Zhang J. (2012)
    133. Reduced protein stability of human DJ-1/PARK7 L166P, l inked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome. (PubMed id 22173095)1 Alvarez-Castelao B....Castano J.G. (2012)
    134. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    135. DJ-1 may contribute to metastasis of non-small cell lu ng cancer. (PubMed id 21670963)1 Bai J....Fu S. (2012)
    136. Stimulation of vesicular monoamine transporter 2 activ ity by DJ-1 in SH-SY5Y cells. (PubMed id 22554508)1 Ishikawa S....Iguchi-Ariga S.M. (2012)
    137. Inactivation of Pink1 gene in vivo sensitizes dopamine -producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and ca n be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. (PubMed id 22511790)1 Haque M.E....Park D.S. (2012)
    138. Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggr egates via TRAF6. (PubMed id 22532838)1 Vilotti S....Zucchelli S. (2012)
    139. DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer. (PubMed id 22526154)1 Chen Y....Wu Y. (2012)
    140. Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1. (PubMed id 22515803)1 Lin J....Wilson M.A. (2012)
    141. Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Za mbian patients with Parkinson's disease. (PubMed id 22445250)1 Yonova-Doing E....Bonifati V. (2012)
    142. DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. (PubMed id 22492997)1 Im J.Y....Mouradian M.M. (2012)
    143. YajL, prokaryotic homolog of parkinsonism-associated p rotein DJ-1, functions as a covalent chaperone for thiol proteome. (PubMed id 22157000)1 Le H.T....Richarme G. (2012)
    144. DJ-1 protein protects dopaminergic neurons against 6-O HDA/MG-132-induced neurotoxicity in rats. (PubMed id 22664331)1 Sun S.Y....Pu X.P. (2012)
    145. YajL, the prokaryotic homolog of the Parkinsonism-asso ciated protein DJ-1, protects cells against protein sulfenylation. (PubMed id 22321799)1 Gautier V....Richarme G. (2012)
    146. Uncovering suitable reference proteins for expression studies in human adipose tissue with relevance to obesity. (PubMed id 22272336)1 Perez-Perez R....Peral B. (2012)
    147. DJ-1 variants in Indian Parkinson's disease patients. (PubMed id 22960331)1 Sadhukhan T....Ray J. (2012)
    148. Human DJ-1 and its homologs are novel glyoxalases. (PubMed id 22523093)1 Lee J.Y....Park C. (2012)
    149. DJ-1 promotes invasion and metastasis of pancreatic ca ncer cells by activating SRC/ERK/uPA. (PubMed id 22223849)1 He X....Yuan Y. (2012)
    150. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro- caspase-8 recruitment to FADD. (PubMed id 21785459)1 Fu K....Wang G. (2012)
    151. High levels of DJ-1 protein in nipple fluid of patient s with breast cancer. (PubMed id 22404125)1 Oda M....Matsubara O. (2012)
    152. Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy. (PubMed id 22836768)1 Bitar M.S....Jurkunas U.V. (2012)
    153. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    154. DJ-1 associates with synaptic membranes. (PubMed id 21645620)1 Usami Y....Hattori N. (2011)
    155. Multiple coregulatory control of tyrosine hydroxylase gene transcription. (PubMed id 21368136)1 Reddy S.D....Kumar R. (2011)
    156. DJ-1 regulation of mitochondrial function and autophag y through oxidative stress. (PubMed id 21317550)1 McCoy M.K. and Cookson M.R. (2011)
    157. DJ-1-Mediated protective effect of protocatechuic ald ehyde against oxidative stress in SH-SY5Y cells. (PubMed id 21160133)1 Gao J.W....Ariga H. (2011)
    158. DJ-1 expression in glioblastomas shows positive corre lation with p53 expression and negative correlation with epidermal growth facto r receptor amplification. (PubMed id 20497343)1 Hinkle D.A....Hamilton R.L. (2011)
    159. Significance and relationship between DJ-1 gene and s urviving gene expression in laryngeal carcinoma. (PubMed id 21556124)1 Shen Z....Ding H. (2011)
    160. Identification of an artificial peptide motif that bin ds and stabilizes reduced human DJ-1. (PubMed id 21893204)1 Premkumar L....Riedl S.J. (2011)
    161. Oxidation of DJ-1 induced by 6-hydroxydopamine decreas ing intracellular glutathione. (PubMed id 22132160)1 Miyama A....Noguchi N. (2011)
    162. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    163. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1 Anderson C.A....Rioux J.D. (2011)
    164. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    165. Down-regulation of DJ-1 protein in the ejaculated spe rmatozoa from Chinese asthenozoospermia patients. (PubMed id 21575935)1 An C.N....Pu X.P. (2011)
    166. The role of DJ-1 in the pathogenesis of endometriosis . (PubMed id 21445310)1 Rai P. and Shivaji S. (2011)
    167. DJ-1 can inhibit microtubule associated protein 1 B fo rmed aggregates. (PubMed id 21645326)1 Wang Z....Chen S. (2011)
    168. Growth inhibitory effects of DJ-1-small interfering R NA on laryngeal carcinoma Hep-2 cells. (PubMed id 20300974)1 Shen Z....Guo J. (2011)
    169. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    170. PRKN, DJ-1, and PINK1 screening identifies novel spli ce site mutation in PRKN and two novel DJ-1 mutations. (PubMed id 21322020)1 Ghazavi F....Elahi E. (2011)
    171. Choice of biological source material supersedes oxida tive stress in its influence on DJ-1 in vivo interactions with Hsp90. (PubMed id 21819105)1 Knobbe C.B....Schmitt-Ulms G. (2011)
    172. [Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients]. (PubMed id 22066264)1 Lisitskaia K.V....Shishkin S.S. (2011)
    173. High glucose upregulation of early-onset Parkinson's d isease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrop hy. (PubMed id 21426932)1 Das F....Choudhury G.G. (2011)
    174. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. (PubMed id 20940149)1 Thomas K.J....Cookson M.R. (2011)
    175. Oxidized DJ-1 interacts with the mitochondrial protei n BCL-XL. (PubMed id 21852238)1 Ren H....Wang G. (2011)
    176. Evaluating intra-genetic variants of DJ-1 among Parkin son's disease patients of eastern India. (PubMed id 21535932)1 Sanyal J....Raghavendra Rao V. (2011)
    177. DJ-1 modulates the expression of Cu/Zn-superoxide dis mutase-1 through the Erk1/2-Elk1 pathway in neuroprotection. (PubMed id 21796667)1 Wang Z....Ding J. (2011)
    178. TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's di sease brains. (PubMed id 20634198)1 Zucchelli S....Gustincich S. (2010)
    179. Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease. (PubMed id 20736773)1 Zhang H.J....Cheung A.N. (2010)
    180. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1 Dubois P.C....van Heel D.A. (2010)
    181. Inhibition of mitochondrial fusion by I+-synuclein is rescued by PINK1, Parkin and DJ-1. (PubMed id 20842103)1 Kamp F....Haass C. (2010)
    182. DJ-1 as a modulator of autophagy: an hypothesis. (PubMed id 20730377)1 GonzA!lez-Polo R.A....Fuentes J.M. (2010)
    183. DJ-1, a cancer and Parkinson's disease associated pro tein, regulates autophagy through JNK pathway in cancer cells. (PubMed id 20510502)1 Ren H....Wang G. (2010)
    184. [DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis]. (PubMed id 21055329)1 Zhu X.L....Wang X.R. (2010)
    185. DJ-1 loss by glutaredoxin but not glutathione depleti on triggers Daxx translocation and cell death. (PubMed id 20014998)1 Saeed U....Ravindranath V. (2010)
    186. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update . (PubMed id 20506312)1 Nuytemans K....Van Broeckhoven C. (2010)
    187. Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. (PubMed id 20395301)1 Foti R....Gustincich S. (2010)
    188. [DJ-1 gene rearrangement mutation in patients with au tosomal recessive early-onset parkinsonism using real-time PCR]. (PubMed id 20543466)1 Zhang H....Tang B. (2010)
    189. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    190. Loss of the Parkinson's disease-linked gene DJ-1 pert urbs mitochondrial dynamics. (PubMed id 20639397)1 Irrcher I....Park D.S. (2010)
    191. L10p and P158DEL DJ-1 mutations cause protein instabi lity, aggregation, and dimerization impairments. (PubMed id 20806408)1 Ramsey C.P. and Giasson B.I. (2010)
    192. Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism. (PubMed id 20146068)1 Guo J.F....Tang B.S. (2010)
    193. Significance and confounders of peripheral DJ-1 and a lpha-synuclein in Parkinson's disease. (PubMed id 20540987)1 Shi M....Zhang J. (2010)
    194. Identification of DJ-1/PARK-7 as a determinant of str oma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry an d phosphopeptide analysis. (PubMed id 20061558)1 Marcondes A.M....Deeg H.J. (2010)
    195. Human DJ-1-specific transcriptional activation of tyr osine hydroxylase gene. (PubMed id 20938049)1 Ishikawa S....Iguchi-Ariga S.M. (2010)
    196. Nrf2 and DJ1 are consistently upregulated in inflamma tory multiple sclerosis lesions. (PubMed id 20673799)1 van Horssen J....de Vries H.E. (2010)
    197. Increased DJ-1 and its prognostic significance in hep atocellular carcinoma. (PubMed id 21410067)1 Liu S....Yi J. (2010)
    198. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    199. Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis. (PubMed id 19014922)1 Lee L.C....Lin J.Y. (2009)
    200. [The expression of DJ-1 gene in human hepatocellular carcinoma and its relationship with tumor invasion and metastasis]. (PubMed id 19335984)1 Wu F....Huang Z.M. (2009)
    201. Oxidizable residues mediating protein stability and c ytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. (PubMed id 19293155)1 Waak J....Kahle P.J. (2009)
    202. Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress. (PubMed id 19371728)1 Gu L....Yang H. (2009)
    203. Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes o f early-stage Parkinson disease patients. (PubMed id 19733211)1 Saito Y....Niki E. (2009)
    204. Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? (PubMed id 19224617)1 Sutherland G.T....Mellick G.D. (2009)
    205. DJ-1 binds to mitochondrial complex I and maintains i ts activity. (PubMed id 19822128)1 Hayashi T....Iguchi-Ariga S.M. (2009)
    206. Structural impact of three Parkinsonism-associated missense mutations on human DJ-1. (PubMed id 18181649)1 Lakshminarasimhan M....Wilson M.A. (2008)
    207. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    208. Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease. (PubMed id 18707128)1 Anderson P.C. and Daggett V. (2008)
    209. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. (PubMed id 17882163)1 Yanagisawa D....Ariga H. (2008)
    210. Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients. (PubMed id 18632777)1 Hirotani M....Sasaki H. (2008)
    211. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. (PubMed id 18556627)1 Malhotra D....Biswal S. (2008)
    212. Mechanisms of DJ-1 neuroprotection in a cellular mode l of Parkinson's disease. (PubMed id 18331584)1 Liu F....Rochet J.C. (2008)
    213. DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains. (PubMed id 18586035)1 Tsuboi Y....Ariga H. (2008)
    214. Secretion of DJ-1 into the serum of patients with Parkinson's disease. (PubMed id 18162323)1 Maita C....Ariga H. (2008)
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    216. Role of NonO-histone interaction in TNFalpha-suppresse d prolyl-4-hydroxylase alpha1. (PubMed id 18439917)1 Zhang C....Wang X.L. (2008)
    217. Proteomic identification of down-regulation of oncoprotein DJ-1 and proteasome activator subunit 1 in hepatitis B virus-infected well-differentiated hepatocellular carcinoma. (PubMed id 17671684)1 Zhang D....Koay E.S. (2007)
    218. The tumor suppressor PP2A Abeta regulates the RalA GTPase. (PubMed id 17540176)1 Sablina A.A....Hahn W.C. (2007)
    219. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    220. Structural determinants of the C-terminal helix-kink- helix motif essential for protein stability and survival promoting activity of DJ-1. (PubMed id 17331951)1 GAPrner K....Kahle P.J. (2007)
    221. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. (PubMed id 16707095)1 Waragai M....Hashimoto M. (2006)
    222. Establishment of specific antibodies that recognize C106-oxidized DJ-1. (PubMed id 16781058)1 Ooe H....Ariga H. (2006)
    223. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
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    226. The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. (PubMed id 16570276)1 Pardo M....Zitzmann N. (2006)
    227. Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. (PubMed id 15894486)1 Bandopadhyay R....Lees A.J. (2005)
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    230. The human plasma proteome: a nonredundant list developed by combination of four separate sources. (PubMed id 14718574)1 Anderson N.L....Lobley A. (2004)
    231. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
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    239. Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. (PubMed id 15258905)9 Hod Y. (2004)
    240. Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein. (PubMed id 15955416)9 Bandopadhyay R....Lees A.J. (2005)
    241. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. (PubMed id 19243613)9 Baulac S....Xia W. (2009)
    242. Porcine DJ-1: cloning of PARK7 cDNA, sequence comparison, expression analysis and chromosomal localization. (PubMed id 17268184)9 Larsen K....Bendixen C. (2007)
    243. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. (PubMed id 20157014)9 Hong Z....Zhang J. (2010)
    244. Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection. (PubMed id 18377993)9 Lev N....Offen D. (2008)
    245. Specific cleavage of DJ-1 under an oxidative condition. (PubMed id 16935423)9 Ooe H....Ariga H. (2006)
    246. Localization of DJ-1 mRNA in the mouse brain. (PubMed id 15337248)9 Shang H....Kaelin-Lang A. (2004)
    247. DJ-1 protects the nigrostriatal axis from the neuroto xin MPTP by modulation of the AKT pathway. (PubMed id 20133695)9 Aleyasin H....Park D.S. (2010)
    248. Identification of novel proteins associated with both alpha-synuclein and DJ-1. (PubMed id 16854843)9 Jin J....Zhang J. (2007)
    249. In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized. (PubMed id 18601999)9 Terracciano C....Askanas V. (2008)
    250. Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. (PubMed id 16298734)9 Li H.M....Ariga H. (2005)
    251. DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. (PubMed id 20089532)9 Ramsey C.P....Giasson B.I. (2010)
    252. DJ-1 is critical for mitochondrial function and rescu es PINK1 loss of function. (PubMed id 20457924)9 Hao L.Y....Bonini N.M. (2010)
    253. Oxidative stress induction of DJ-1 protein in reactiv e astrocytes scavenges free radicals and reduces cell injury. (PubMed id 20046643)9 Yanagida T....Ariga H. (2009)
    254. Dissembled DJ-1 high molecular weight complex in cort ex mitochondria from Parkinson's disease patients. (PubMed id 19497122)9 Nural H....Shen Y. (2009)
    255. DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders. (PubMed id 17719794)9 Kumaran R....Bandopadhyay R. (2007)
    256. Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons. (PubMed id 16942755)9 Bai Q....Burton E.A. (2006)
    257. Identification of the epitope of a monoclonal antibod y to DJ-1. (PubMed id 15663963)9 Miller D.W....Cookson M.R. (2005)
    258. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. (PubMed id 14991385)9 Neumann M....Kahle P.J. (2004)
    259. DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity. (PubMed id 20202083)9 Yamashita S....Uchino M. (2010)
    260. DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death. (PubMed id 18309325)9 Mo J.S....Park H.S. (2008)
    261. DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone. (PubMed id 18930142)9 Mullett S.J. and Hinkle D.A. (2009)
    262. Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease. (PubMed id 19146923)9 Blackinton J....Cookson M.R. (2009)
    263. The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. (PubMed id 18003894)9 Aleyasin H....Park D.S. (2007)
    264. alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity. (PubMed id 16978583)9 Colapinto M....Fasano M. (2006)
    265. Mutations in DJ-1 are rare in familial Parkinson disease. (PubMed id 16997464)9 Pankratz N....Nichols W.C. (2006)
    266. Stimulation of transforming activity of DJ-1 by Abstrakt, a DJ-1-binding protein. (PubMed id 15703824)9 Sekito A....Ariga H. (2005)
    267. Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. (PubMed id 15799973)9 Chen L....Zhuang X. (2005)
    268. Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. (PubMed id 15081400)9 Kinumi T....Niki E. (2004)
    269. DJ-1 mutations in Parkinson's disease. (PubMed id 14707326)9 Healy D.G....Wood N.W. (2004)
    270. The atomic resolution crystal structure of the YajL ( ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parki nsonism-associated protein DJ-1. (PubMed id 16181642)9 Wilson M.A....Petsko G.A. (2005)
    271. [The expression of DJ-1 protein in proteomic analysis of late-onset Alzheimer disease] (PubMed id 19576113)9 Chen X.H....Liu B.Y. (2009)
    272. T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease. (PubMed id 17030667)9 Chishti M.A.... Rogaeva E. (2006)
    273. Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? (PubMed id 15576821)9 Giasson B.I. (2004)
    274. Parkin and PINK1 parkinsonism may represent nigral mi tochondrial cytopathies distinct from Lewy body Parkinson's disease. (PubMed id 19815446)9 Ahlskog J.E. (2009)
    275. Is olfactory impairment in Parkinson disease related to phenotypic or genotypic characteristics? (PubMed id 19047559)9 Verbaan D....van Hilten J.J. (2008)
    276. Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease. (PubMed id 17975812)9 Quattrone A....Condino F. (2008)
    277. Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway? (PubMed id 19021753)9 Fitzgerald J.C. and Plun-Favreau H. (2008)
    278. High-throughput homogeneous mass cleave assay technology for the diagnosis of autosomal recessive Parkinson's disease. (PubMed id 18403612)9 Schroeder C....Bonin M. (2008)
    279. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. (PubMed id 17499497)9 Dodson M.W. and Guo M. (2007)
    280. Multiplex ligation-dependent probe amplification assay for simultaneous detection of Parkinson's disease gene rearrangements. (PubMed id 17914726)9 Scarciolla O....Dallapiccola B. (2007)
    281. [Molecular genetics of PINK1] (PubMed id 17713119)9 Funayama M. and Hattori N. (2007)
    282. Etiology of Parkinson's disease. (PubMed id 16717248)9 Schapira A.H. (2006)
    283. Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. (PubMed id 16439141)9 Betarbet R....Greenamyre J.T. (2006)
    284. The biochemistry of Parkinson's disease. (PubMed id 15952880)9 Cookson M.R. (2005)
    285. Genetics of Parkinson's disease. (PubMed id 16175160)9 Bonifati V. (2005)
    286. Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study. (PubMed id 15966003)9 Karamohamed S....Myers R.H. (2005)
    287. PET neuroimaging and mutations in the DJ-1 gene. (PubMed id 15565491)9 Dekker M.C....Leenders K.L. (2004)
    288. Proteomics-based safety evaluation of multi-walled ca rbon nanotubes. (PubMed id 19874835)9 Haniu H....Endo M. (2010)
    289. Mitochondrial metabolism modulation: a new therapeuti c approach for Parkinson's disease. (PubMed id 20201821)9 ArduA-no D.M....Cardoso S.M. (2010)
    290. Clinical implications of gene discovery in Parkinson' s disease and parkinsonism. (PubMed id 20187245)9 Wider C....Wszolek Z.K. (2010)
    291. Tickled PINK1: mitochondrial homeostasis and autophag y in recessive Parkinsonism. (PubMed id 19595762)9 Chu C.T. (2010)
    292. Genetic basis of Parkinson disease. (PubMed id 20043722)9 Xiromerisiou G....Hadjigeorgiou G.M. (2010)
    293. Parkinson's disease: insights from pathways. (PubMed id 20421364)9 Cookson M.R. and Bandmann O. (2010)
    294. Comment on 'compound heterozygosity in DJ-1 gene non-coding portion related to Parkinsonism'. (PubMed id 20227322)9 Sironi F....Goldwurm S. (2010)
    295. Absence of nigral degeneration in aged parkin/DJ-1/PI NK1 triple knockout mice. (PubMed id 19694908)9 Kitada T....Shen J. (2009)
    296. A role for a novel protein, nucleolin, in Parkinson's disease. (PubMed id 19409963)9 Caudle W.M....Zhang J. (2009)
    297. Cell death pathways in Parkinson's disease: role of m itochondria. (PubMed id 19422283)9 Yao Z. and Wood N.W. (2009)
    298. Etiology and pathogenesis of Parkinson disease. (PubMed id 19555823)9 Schapira A.H. (2009)
    299. Early involvement of the cerebral cortex in Parkinson 's disease: convergence of multiple metabolic defects. (PubMed id 19482226)9 Ferrer I. (2009)
    300. Imaging the impact of genes on Parkinson's disease. (PubMed id 19409223)9 van der Vegt J.P....Siebner H.R. (2009)
    301. Impaired mitochondrial dynamics and function in the p athogenesis of Parkinson's disease. (PubMed id 19303005)9 BA1eler H. (2009)
    302. Molecular pathogenesis of Parkinson disease: insights from genetic studies. (PubMed id 19631006)9 Gasser T. (2009)
    303. Protein degradation in Parkinson disease revisited: it's complex. (PubMed id 19306499)9 Li H. and Guo M. (2009)
    304. Parkinson's disease: from monogenic forms to genetic susceptibility factors. (PubMed id 19297401)9 Lesage S. and Brice A. (2009)
    305. Molecular basis of Parkinson's disease. (PubMed id 19151598)9 Yang Y.X....Latchman D.S. (2009)
    306. Mitochondrial kinases in Parkinson's disease: converg ing insights from neurotoxin and genetic models. (PubMed id 19563915)9 Dagda R.K....Chu C.T. (2009)
    307. Mitochondrial dysfunction and biogenesis in the patho genesis of Parkinson's disease. (PubMed id 20035637)9 Lin T.K....Chuang J.H. (2009)
    308. From genes to proteins in mendelian Parkinson's disea se: an overview. (PubMed id 19943343)9 Pirkevi C....BaA9ak A.N. (2009)
    309. Complicated recessive dystonia parkinsonism syndromes. (PubMed id 19185014)9 Schneider S.A....Hardy J. (2009)
    310. The role of PTEN-induced kinase 1 in mitochondrial dy sfunction and dynamics. (PubMed id 19703660)9 Thomas K.J. and Cookson M.R. (2009)
    311. Whole-genome conditional two-locus analysis identifie s novel candidate genes for late-onset Parkinson's disease. (PubMed id 19156451)9 GonzA!lez-PAcrez A....Ruiz A. (2009)
    312. Is there a pathogenic role for mitochondria in Parkin son's disease? (PubMed id 20083000)9 Vives-Bauza C....Przedborski S. (2009)
    313. Neurodegeneration in Parkinson's disease: genetics en lightens physiopathology. (PubMed id 20411780)9 Corti O....Brice A. (2009)
    314. Transgenic rodent models of Parkinson's disease. (PubMed id 18642640)9 Harvey B.K....Hoffer B.J. (2008)
    315. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. (PubMed id 18978800)9 Henchcliffe C. and Beal M.F. (2008)
    316. Proteomic analysis of cervical cancer cells treated with adenovirus-mediated MDA-7. (PubMed id 18299662)9 Wei L....Song F. (2008)
    317. Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? (PubMed id 17680806)9 Bogaerts V....van Broeckhoven C. (2008)
    318. Structure of the stress response protein DR1199 from Deinococcus radiodurans: a member of the DJ-1 superfamily. (PubMed id 18850720)9 Fioravanti E....McSweeney S. (2008)
    319. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. (PubMed id 18093566)9 Schapira A.H. (2008)
    320. On the pathogenesis and neuroprotective treatment of Parkinson disease: what have we learned from the genetic forms of this disease? (PubMed id 18855661)9 Mena M.A....de Yebenes J.G. (2008)
    321. [Parkin and mitochondria] (PubMed id 18717196)9 Mitsui T....Kaji R. (2008)
    322. Programmed cell death and new discoveries in the genetics of parkinsonism. (PubMed id 17996022)9 Burke R.E. (2008)
    323. Overexpression of calcineurin B subunit (CnB) enhances the oncogenic potential of HEK293 cells. (PubMed id 18422742)9 Wang Y.L....Wei Q. (2008)
    324. Proteome analysis of human substantia nigra in Parkinson's disease. (PubMed id 18275612)9 Werner C.J....Wolf S. (2008)
    325. Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism. (PubMed id 19087301)9 Myhre R....Klungland H. (2008)
    326. Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. (PubMed id 18759352)9 Tomiyama H....Kuzuhara S. (2008)
    327. Update on the pathogenesis of Parkinson's disease. (PubMed id 18787877)9 Schulz J.B. (2008)
    328. Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker. (PubMed id 17303689)9 Melle C....von Eggeling F. (2007)
    329. Parkinson's disease. (PubMed id 17911161)9 Thomas B. and Beal M.F. (2007)
    330. Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease. (PubMed id 17010972)9 Liang C.L....German D.C. (2007)
    331. Genetics of parkinsonism. (PubMed id 18267242)9 Bonifati V. (2007)
    332. [Pathology of familial Parkinson's disease] (PubMed id 17713121)9 Wakabayashi K. and Takahashi H. (2007)
    333. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. (PubMed id 18220780)9 Nunomura A....Perry G. (2007)
    334. Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder. (PubMed id 17761553)9 Klein C. and Schlossmacher M.G. (2007)
    335. Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease. (PubMed id 17521740)9 Sun F....Kanthasamy A.G. (2007)
    336. Impact of recent genetic findings in Parkinson's disease. (PubMed id 17620882)9 Klein C. and Lohmann-Hedrich K. (2007)
    337. A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis. (PubMed id 17914725)9 Valkovic P....Gasser T. (2007)
    338. Are Parkinson disease patients protected from some but not all cancers? (PubMed id 17699801)9 Inzelberg R. and Jankovic J. (2007)
    339. Genetics of Parkinson's disease and parkinsonism. (PubMed id 17563249)9 Douglas M.R....Nicholl D.J. (2007)
    340. Mitochondria and neurodegeneration. (PubMed id 18074639)9 Beal M.F. (2007)
    341. The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease. (PubMed id 17352347)9 Cho J.W....Jeon B.S. (2007)
    342. Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease. (PubMed id 17415511)9 Schweitzer K.J....Berg D. (2007)
    343. Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stability. (PubMed id 16652386)9 Pitkanen-Arsiola T....Kasper S. (2006)
    344. Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor. (PubMed id 16356647)9 Jeong H....Seol W. (2006)
    345. The genetics of Parkinson disease: Implications for neurological care. (PubMed id 16932540)9 Klein C. and Schlossmacher M.G. (2006)
    346. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. (PubMed id 16860563)9 Inden M....Ariga H. (2006)
    347. Understanding the molecular causes of Parkinson's disease. (PubMed id 17027339)9 Wood-Kaczmar A....Wood N.W. (2006)
    348. Cloning, expression, and purification of the general stress protein YhbO from Escherichia coli. (PubMed id 16380269)9 Abdallah J....Richarme G. (2006)
    349. Recessive Parkinson's disease. (PubMed id 16615060)9 Kubo S....Mizuno Y. (2006)
    350. Progress in familial Parkinson's disease. (PubMed id 17017529)9 Mizuno Y....Li Y. (2006)
    351. Parkin: a multifaceted ubiquitin ligase. (PubMed id 17052189)9 Moore D.J. (2006)
    352. Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa. (PubMed id 16401616)9 Ibanez P....Brice A. (2006)
    353. Parkinsonism genes: culprits and clues. (PubMed id 16836655)9 Abeliovich A. and Flint Beal M. (2006)
    354. Parkin and defective ubiquitination in Parkinson's disease. (PubMed id 17017531)9 Dawson T.M. (2006)
    355. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. (PubMed id 16472774)9 Goswami A....Jana N.R. (2006)
    356. Genetics of Parkinson's disease. (PubMed id 16026116)9 Morris H.R. (2005)
    357. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. (PubMed id 16139213)9 Meulener M....Bonini N.M. (2005)
    358. Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells. (PubMed id 16115732)9 Nishinaga H....Ariga H. (2005)
    359. Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease. (PubMed id 15790536)9 Jin J....Zhang J. (2005)
    360. Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization. (PubMed id 15790532)9 Blackinton J....Cookson M.R. (2005)
    361. Genetic testing in Parkinson's disease. (PubMed id 15503301)9 McInerney-Leo A....Hardy J. (2005)
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