Aliases for PARK7 Gene
Aliases for PARK7 Gene
- Parkinsonism Associated Deglycase 2 3 5
- Parkinson Disease (Autosomal Recessive, Early Onset) 7 2 3
- Parkinson Protein 7 2 3
- Maillard Deglycase 3 4
- Oncogene DJ1 3 4
- Protein DJ-1 3 4
- DJ-1 3 4
- Epididymis Secretory Sperm Binding Protein Li 67p 3
- Protein/Nucleic Acid Deglycase DJ-1 3
- Parkinsonism-Associated Deglycase 4
External Ids for PARK7 Gene
- HGNC: 16369
- Entrez Gene: 11315
- Ensembl: ENSG00000116288
- OMIM: 602533
- UniProtKB: Q99497
Previous GeneCards Identifiers for PARK7 Gene
- GC01U990455
- GC01P007830
- GC01P007618
- GC01P007731
- GC01P007956
- GC01P007944
- GC01P007169
- GC01P008014
Summaries for PARK7 Gene
-
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARK7 Gene
PARK7 (Parkinsonism Associated Deglycase) is a Protein Coding gene. Diseases associated with PARK7 include Parkinson Disease 7, Autosomal Recessive Early-Onset and Parkinson Disease 6, Autosomal Recessive Early-Onset. Among its related pathways are Alpha-synuclein signaling and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and receptor binding.
UniProtKB/Swiss-Prot for PARK7 Gene
-
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity (PubMed:22523093). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785, PubMed:26995087). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity).
Additional gene information for PARK7 Gene
- Monarch Initiative
- Search for PARK7 at DataMed
- Search for PARK7 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARK7 Gene
Genomics for PARK7 Gene
GeneHancer (GH) Regulatory Elements for PARK7 Gene
Promoters and enhancers for PARK7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PARK7 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PARK7 gene promoter:
Regulatory Element Products
Genomic Locations for PARK7 Gene
Genomic Locations for PARK7 Gene
- chr1:7,954,291-7,985,505
- (GRCh38/hg38)
- Size:
- 31,215 bases
- Orientation:
- Plus strand
- chr1:8,014,351-8,045,565
- (GRCh37/hg19)
Genomic View for PARK7 Gene
Genes around PARK7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.23 by Ensembl
- 1p36.23 by Entrez Gene
- 1p36.23 by HGNC
PARK7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PARK7 Gene
Proteins for PARK7 Gene
-
Protein details for PARK7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99497-PARK7_HUMAN
- Recommended name:
- Protein/nucleic acid deglycase DJ-1
- Protein Accession:
- Q99497
- B2R4Z1
- O14805
- Q6DR95
- Q7LFU2
Protein attributes for PARK7 Gene
- Size:
- 189 amino acids
- Molecular mass:
- 19891 Da
- Quaternary structure:
-
- Homodimer (PubMed:12851414, PubMed:12796482, PubMed:12855764). Binds EFCAB6/DJBP and PIAS2 (PubMed:11477070, PubMed:12851414, PubMed:12612053). Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (PubMed:12612053). Interacts (via N-terminus) with OTUD7B (PubMed:21097510). Interacts with BBS1, HIPK1, CLCF1 and MTERF (PubMed:16390825, PubMed:21097510). Forms a complex with PINK1 and PRKN (PubMed:19229105). Interacts (via C-terminus) with NCF1; the interaction is enhanced by LPS and modulates NCF1 phosphorylation and membrane translocation (By similarity).
Protein Expression for PARK7 Gene
Post-translational modifications for PARK7 Gene
- Cys-106 is easily oxidized to sulfinic acid.
- Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for cell-growth promoting activity and transforming activity.
- Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress.
- Ubiquitination at isoforms=99 and isoforms=148
Other Protein References for PARK7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PARK7 (Park7/DJ-1)
- Cell Signaling Technology (CST) Antibodies for PARK7 (DJ-1)
- Novus Biologicals Antibodies for PARK7
-
Abcam antibodies for PARK7
-
Cloud-Clone Corp. Antibodies for PARK7
- Invitrogen Antibodies for PARK7
- antibodies-online: Search results for 267 available PARK7 Antibodies ranked by validation data
- Compare Top PARK7 Antibodies
-
Recommended
- 87 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 203 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 70 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- GeneTex PARK7 antibody for PARK7
-
Santa Cruz Biotechnology (SCBT) Antibodies for PARK7
- Sino Biological Antibodies for PARK7
Protein Products
-
OriGene Purified Proteins for PARK7
- Search Origene for MassSpec and Protein Over-expression Lysates for PARK7
- Origene Custom Protein Services for PARK7
- Sino Biological Recombinant Proteins for PARK7
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PARK7
-
Cloud-Clone Corp. Proteins for PARK7
- Search GeneTex for Proteins for PARK7
-
Abcam proteins for PARK7
Assay Products
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for PARK7 (Park7/DJ-1)
-
Abcam assays for PARK7
No data available for DME Specific Peptides for PARK7 Gene
Domains & Families for PARK7 Gene
Gene Families for PARK7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for PARK7 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PARK7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99497- Family:
-
- Belongs to the peptidase C56 family.
Function for PARK7 Gene
Molecular function for PARK7 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=173.4 uM for casein {ECO:0000269 PubMed:20304780}; KM=0.44 mM for glycated N-acetylarginine (at pH 7.0 and 22 degrees Celsius) {ECO:0000269 PubMed:25416785}; KM=0.35 mM for glycated N-acetyllysine (at pH 7.0 and 22 degrees Celsius) {ECO:0000269 PubMed:25416785}; KM=0.32 mM for glycated N-acetylcysteine (at pH 7.0 and 22 degrees Celsius) {ECO:0000269 PubMed:25416785}; Note=kcat is 0.27 sec(-1) for the deglycation of glycated N- acetylarginine. kcat is 0.28 sec(-1) for the deglycation of glycated N-acetyllysine. kcat is 0.42 sec(-1) for the deglycation of glycated N-acetylcysteine. {ECO:0000269 PubMed:25416785};
- UniProtKB/Swiss-Prot CatalyticActivity:
- An N(omega)-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H(2)O = a [protein]-L-arginine + (R)-lactate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + (R)-lactate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- An S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H(2)O = a [protein]-L-cysteine + (R)-lactate.
- UniProtKB/Swiss-Prot Function:
- Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity (PubMed:22523093). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785, PubMed:26995087). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By hydrogen peroxide and UV irradiation (PubMed:14749723, PubMed:15976810). In pancreatic islets, expression increases under hyperglycemic conditions (PubMed:22611253). Expression is also induced by sulforaphane, an isothiocyanate obtained from cruciferous vegetables (PubMed:26995087).
Enzyme Numbers (IUBMB) for PARK7 Gene
Phenotypes From GWAS Catalog for PARK7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001047 | NOT core promoter binding | IC | 15790595 |
| GO:0003690 | NOT double-stranded DNA binding | IDA | 22683601 |
| GO:0003697 | NOT single-stranded DNA binding | IDA | 22683601 |
| GO:0003713 | transcription coactivator activity | TAS | 16731528 |
| GO:0003723 | RNA binding | IEA | -- |
Phenotypes for PARK7 Gene
- MGI mutant phenotypes for PARK7:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for PARK7:
Animal Models for PARK7 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PARK7
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PARK7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PARK7 gene
- Search ViGene Biosciences for PARK7
CRISPR Products
-
OriGene CRISPR knockouts for PARK7
- genomics-online: gRNA clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
- Applied Biological Materials CRISPR for PARK7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PARK7
- GenScript: Design CRISPR guide RNA sequences for PARK7
miRNA for PARK7 Gene
- miRTarBase miRNAs that target PARK7
-
- hsa-mir-26b-5p (MIRT029955)
- hsa-mir-92b-3p (MIRT040717)
- hsa-mir-222-3p (MIRT046823)
- hsa-mir-92a-3p (MIRT049137)
- hsa-mir-5680 (MIRT290040)
- hsa-mir-4438 (MIRT562976)
- hsa-mir-3674 (MIRT562977)
- hsa-mir-135b-3p (MIRT562978)
- hsa-mir-6806-5p (MIRT562979)
- hsa-mir-203a-3p (MIRT562980)
- hsa-mir-4478 (MIRT562981)
- hsa-mir-4419b (MIRT562982)
- hsa-mir-3929 (MIRT562983)
miRNA Products
- Search ViGene Biosciences for PARK7
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PARK7
- Browse OriGene Inhibitory RNA Products For PARK7
- genomics-online: shRNA clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for PARK7 gene
Clone Products
- Sino Biological Human cDNA Clone for PARK7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PARK7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PARK7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PARK7
- genomics-online: cdna clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
- orf clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
- Applied Biological Materials Clones for PARK7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PARK7
-
ViGene Biosciences adenoviral particle packaged cDNA for PARK7 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PARK7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PARK7 gene
No data available for Transcription Factor Targets and HOMER Transcription for PARK7 Gene
Localization for PARK7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PARK7 Gene
- Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. {ECO:0000269 PubMed:14705119, ECO:0000269 PubMed:18711745}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 3 |
| cytoskeleton | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA | 16731528 |
| GO:0005634 | nucleus | IDA | 11477070 |
| GO:0005737 | cytoplasm | IDA,IEA | 12446870 |
| GO:0005739 | mitochondrion | IMP | 21785459 |
| GO:0005747 | colocalizes_with mitochondrial respiratory chain complex I | IDA | 19822128 |
Pathways & Interactions for PARK7 Gene
Pathways by source for PARK7 Gene
2 Cell Signaling Technology pathways for PARK7 Gene
4 BioSystems pathways for PARK7 Gene
1 KEGG pathway for PARK7 Gene
1 Qiagen pathway for PARK7 Gene
Interacting Proteins for PARK7 Gene
Selected Interacting proteins:
ENSP00000340278
Q99497-PARK7_HUMAN
for PARK7 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001933 | negative regulation of protein phosphorylation | IGI | 15983381 |
| GO:0001963 | synaptic transmission, dopaminergic | IEA | -- |
| GO:0002866 | positive regulation of acute inflammatory response to antigenic stimulus | ISS | -- |
| GO:0006281 | DNA repair | IEA,IDA | 28596309 |
| GO:0006469 | negative regulation of protein kinase activity | IGI | 15983381 |
No data available for SIGNOR curated interactions for PARK7 Gene
Drugs & Compounds for PARK7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 202 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PARK7 Gene
mRNA/cDNA for PARK7 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (818) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PARK7
- genomics-online: gRNA clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
- Applied Biological Materials CRISPR for PARK7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PARK7
- GenScript: Design CRISPR guide RNA sequences for PARK7
miRNA Products
- Search ViGene Biosciences for PARK7
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PARK7
- Browse OriGene Inhibitory RNA Products For PARK7
- genomics-online: shRNA clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for PARK7 gene
Clone Products
- Sino Biological Human cDNA Clone for PARK7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PARK7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PARK7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PARK7
- genomics-online: cdna clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
- orf clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
- Applied Biological Materials Clones for PARK7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP8: |
Expression for PARK7 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARK7 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PARK7 Gene:
PARK7SOURCE GeneReport for Unigene cluster for PARK7 Gene:
Hs.419640mRNA Expression by UniProt/SwissProt for PARK7 Gene:
Q99497-PARK7_HUMAN
Tissue specificity:
Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Expressed by pancreatic islets at higher levels than surrounding exocrine tissues (PubMed:22611253).
Evidence on tissue expression from TISSUES for PARK7 Gene
- Nervous system(5)
- Lung(4.8)
- Liver(4.7)
- Kidney(4.6)
- Eye(3.6)
- Blood(3.4)
- Muscle(3.2)
- Heart(3)
- Pancreas(3)
- Adrenal gland(2.3)
- Thyroid gland(2.3)
- Lymph node(2.2)
- Intestine(2.1)
- Spleen(2.1)
- Stomach(2.1)
- Gall bladder(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PARK7 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeletal muscle
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- eyelid
- face
- head
- jaw
- mandible
- maxilla
- mouth
- nose
- skull
- tongue
Pelvis:
- urethra
- urinary bladder
Limb:
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for PARK7
-
OriGene qPCR primer pairs and template standards for PARK7
- genomics-online: primer clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
-
Recommended
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PARK7 Gene
Orthologs for PARK7 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PARK7 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PARK7 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PARK7 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PARK7 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Park7 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Park7 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PARK7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DJ-1 34 |
|
OneToOne | |
| PARK7 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | PARK7 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | park7 33 |
|
||
| Str.15245 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11413 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | park7 33 34 |
|
||
| Dr.15530 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9560 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | DJ-1alpha 33 34 |
|
||
| dj-1beta 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | djr-1.1 33 34 |
|
||
| djr-1.2 34 |
|
OneToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G53280 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0531200 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC22E12.03c 33 |
|
- Species where no ortholog for PARK7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PARK7 Gene
Pseudogenes.org Pseudogenes for PARK7 Gene
No data available for Paralogs for PARK7 Gene
Variants for PARK7 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1033278626 | uncertain-significance, Parkinson Disease, Recessive | 7,961,787(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs11121064 | likely-benign, Parkinson Disease, Recessive | 7,961,747(+) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs11548933 | likely-benign, Parkinson Disease, Recessive | 7,962,764(+) | C/G/T | 5_prime_UTR_variant | |
| rs11548937 | likely-benign, benign, Parkinson Disease, Recessive, Parkinson disease 7 | 7,969,386(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs137853051 | pathogenic, Parkinson disease, autosomal recessive early-onset, digenic, PINK1/DJ1 | 7,965,348(+) | G/T | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.70;
32.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PARK7 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARK7 Gene
Disorders for PARK7 Gene
(16) MalaCards diseases for PARK7 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| parkinson disease 7, autosomal recessive early-onset |
|
|
| parkinson disease 6, autosomal recessive early-onset |
|
|
| parkinson disease 2, autosomal recessive juvenile |
|
|
| early-onset parkinson disease |
|
|
| amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 |
|
|
Search PARK7 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PARK7_HUMAN- Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). {ECO:0000269 PubMed:12446870, ECO:0000269 PubMed:12851414, ECO:0000269 PubMed:12953260, ECO:0000269 PubMed:14607841, ECO:0000269 PubMed:14713311, ECO:0000269 PubMed:15254937, ECO:0000269 PubMed:15365989, ECO:0000269 PubMed:17846173, ECO:0000269 PubMed:19229105, ECO:0000269 PubMed:22523093, ECO:0000269 PubMed:23792957, ECO:0000269 PubMed:23847046}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PARK7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PARK7 Gene
Publications for PARK7 Gene
- DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. (PMID: 14872018) Hedrich K … Klein C (Neurology 2004) 3 4 22 44 58
- DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. (PMID: 9070310) Nagakubo D … Ariga H (Biochemical and biophysical research communications 1997) 2 3 4 22 58
- Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. (PMID: 28596309) Richarme G … Lamouri A (Science (New York, N.Y.) 2017) 2 3 4 58
- Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. (PMID: 25416785) Richarme G … Lamouri A (The Journal of biological chemistry 2015) 2 3 4 58
- Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. (PMID: 20186336) Krebiehl G … Krüger R (PloS one 2010) 3 4 22 58
Products for PARK7 Gene
- R&D Systems Antibodies for PARK7 (Park7/DJ-1)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for PARK7 (Park7/DJ-1)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for PARK7
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PARK7
- Search Origene for MassSpec and Protein Over-expression Lysates for PARK7
- Origene Custom Protein Services for PARK7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PARK7
- Browse OriGene Inhibitory RNA Products For PARK7
- OriGene qPCR primer pairs and template standards for PARK7
- OriGene qPCR primer pairs for PARK7
- OriGene CRISPR knockouts for PARK7
- OriGene ORF clones in human for PARK7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for PARK7 in any vector
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- GenScript: Design CRISPR guide RNA sequences for PARK7
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PARK7
- Cell Signaling Technology (CST) Antibodies for PARK7 (DJ-1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for PARK7
- Sino Biological Recombinant Proteins for PARK7
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PARK7
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PARK7
- Novus Biologicals lysates and proteins for PARK7
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for PARK7
- Abcam proteins for PARK7
- Abcam assays for PARK7
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PARK7
- Cloud-Clone Corp. Antibodies for PARK7
- Cloud-Clone Corp. Proteins for PARK7
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PARK7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for PARK7
- VectorBuilder custom plasmid, inducible vectors for PARK7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PARK7
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PARK7
- antibodies-online: Search results for 267 available PARK7 Antibodies ranked by validation data
- Compare Top PARK7 Antibodies
- Recommended
- 87 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 203 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 70 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Search results for 23 available PARK7 Elisa Kits ranked by validation data
- Compare Top PARK7 Elisa Kits
- antibodies-online: Search results for 30 available PARK7 Proteins ranked by validation data
- Compare Top PARK7 Proteins
- GeneTex PARK7 antibody for PARK7
- Search GeneTex for Proteins for PARK7
- ViGene Biosciences adenoviral particle packaged cDNA for PARK7 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PARK7 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PARK7 gene
- Search ViGene Biosciences for PARK7
- Santa Cruz Biotechnology (SCBT) Antibodies for PARK7
- Search Santa Cruz Biotechnology (SCBT) for PARK7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PARK7
- Horizon Cell Lines for PARK7
- genomics-online: cdna clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
- Recommended
- orf clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
- Recommended
- genomics-online: primer clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 152 available PARK7 gene related products
- Overview of 152 available PARK7 gene related products
- Recommended
Sources for PARK7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew