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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PARK7 Gene

protein-coding GIFtS: 69
GCID: GC01P008014

Parkinson Protein 7

(Previous names: Parkinson disease (autosomal recessive, early onset) 7)

Microbiology & Infectious Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Parkinson Protein 7¹ ²		DJ-1²
Parkinson Disease (Autosomal Recessive, Early Onset) 7¹ ²		Protein DJ-1²
Oncogene DJ1² ³		EC 3.4.-.-³
DJ1² ⁵		Parkinson Disease Protein 7³

External Ids:	HGNC: 16369¹	Entrez Gene: 11315²	Ensembl: ENSG00000116288⁷	OMIM: 602533⁵	UniProtKB: Q99497³

Export aliases for PARK7 gene to outside databases

Previous GC identifers: GC01U990455 GC01P007830 GC01P007618 GC01P007731 GC01P007956 GC01P007944 GC01P007169

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PARK7 Gene:

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of

androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for

oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this

gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the

same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PARK7 Gene:

PARK7 (parkinson protein 7) is a protein-coding gene. Diseases associated with PARK7 include amyotrophic lateral sclerosis-parkinsonism/dementia complex 1, and park7-related parkinson disease, and among its related super-pathways are Electron Transport Chain and Synaptic vesicle cycle. GO annotations related to this gene include mRNA binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497

Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or

stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the

substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via

L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen

peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen

peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective

action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and

its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear

translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits

their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and

function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a

positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in

fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May

function as a redox-sensitive chaperone

Gene Wiki entry for PARK7 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_021937.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PARK7 gene promoter:
PPAR-gamma1 POU2F1 SREBP-1a AML1a POU2F1a SREBP-1c PPAR-gamma2 Pax-4a SREBP-1b c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PARK7 promoter sequence

Search SABiosciences Chromatin IP Primers for PARK7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARK7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.23

PARK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARK7 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P008014: view genomic region (about GC identifiers)

Start:	8,014,351 bp from pter	End:	8,045,565 bp from pter
Size:	31,215 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497 (See protein sequence)

Recommended Name: Protein DJ-1 precursor

Size: 189 amino acids; 19891 Da

Subunit: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.

Interacts (via N-terminus) with OTUD7B. Interacts with BBS1, HIPK1, CLCF1 and MTERF

Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Under normal conditions, located predominantly in

the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and

subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against

oxidative damage. Detected in tau inclusions in brains from neurodegenerative disease patients

6/26 PDB 3D structures from and Proteopedia for PARK7 (see all 26):

1J42 (3D)

1P5F (3D)

1PDV (3D)

1PDW (3D)

1PE0 (3D)

1Q2U (3D)

Secondary accessions: B2R4Z1 O14805 Q6DR95 Q7LFU2

Explore the universe of human proteins at neXtProt for PARK7: NX_Q99497

Explore proteomics data for PARK7 at MOPED

Post-translational modifications:

UniProtKB: Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for

cell-growth promoting activity and transforming activity

UniProtKB: Cys-106 is easily oxidized to sulfinic acid

UniProtKB: Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative

stress

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q99497

PARK7 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001116849.1 NP_009193.2

ENSEMBL proteins:

ENSP00000465404 ENSP00000340278 ENSP00000418770 ENSP00000466242 ENSP00000366711

ENSP00000366708 ENSP00000466756

Human Recombinant Protein Products for PARK7:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for PARK7 OriGene Protein Over-expression Lysate for PARK7 OriGene MassSpec for PARK7 OriGene Custom Protein Services for PARK7
	GenScript Custom Purified and Recombinant Proteins Services for PARK7
	Novus Biologicals PARK7 Proteins Novus Biologicals PARK7 Lysates
	Sino Biological Recombinant Protein for PARK7 Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for PARK7
	Cloud-Clone Corp. Proteins for PARK7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11477070
GO:0005737	cytoplasm	IDA	12446870
GO:0005739	mitochondrion	IDA	18711745

PARK7 for ontologies About GeneDecksing

PARK7 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PARK7
	R&D Systems Antibodies for PARK7 (Park7/DJ-1)
	Cell Signaling Technology (CST) Antibodies for PARK7 (DJ-1)
	OriGene Antibodies for PARK7 OriGene Custom Antibody Services for PARK7
	GenScript Superior Antibodies for PARK7
	Novus Biologicals PARK7 Antibodies
	Abcam antibodies for PARK7
	Cloud-Clone Corp. Antibodies for PARK7
	ThermoFisher Antibody for PARK7
	LSBio Antibodies in human, mouse, rat for PARK7

Assay Products for PARK7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PARK7
	R&D Systems ELISAs for PARK7 (Park7/DJ-1)
	GenScript Custom Assay Services for PARK7
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PARK7 Cloud-Clone Corp. CLIAs for PARK7

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

PARK: Parkinson disease

2 InterPro protein domains:

IPR006287 DJ1

IPR002818 ThiJ/PfpI

Graphical View of Domain Structure for InterPro Entry Q99497

ProtoNet protein and cluster: Q99497

1 Blocks protein domain: IPB002818 Family of unknown function ThiJ/PfpI

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497

Similarity: Belongs to the peptidase C56 family

PARK7 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PARK7_HUMAN, Q99497