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Aliases for PARK7 Gene

Aliases for PARK7 Gene

  • Parkinson Protein 7 2 3
  • Parkinson Disease (Autosomal Recessive, Early Onset) 7 2 3
  • Oncogene DJ1 3 4
  • DJ-1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 67p 3
  • Parkinson Disease Protein 7 4
  • Protein DJ-1 3
  • EC 3.1.2.- 4
  • EC 3.5.1.- 4
  • HEL-S-67p 3
  • DJ1 3

External Ids for PARK7 Gene

Previous GeneCards Identifiers for PARK7 Gene

  • GC01U990455
  • GC01P007830
  • GC01P007618
  • GC01P007731
  • GC01P007956
  • GC01P007944
  • GC01P007169
  • GC01P008014

Summaries for PARK7 Gene

Entrez Gene Summary for PARK7 Gene

  • The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARK7 Gene

PARK7 (Parkinson Protein 7) is a Protein Coding gene. Diseases associated with PARK7 include parkinson disease 7, autosomal recessive early-onset and park7-related parkinson disease. Among its related pathways are Alpha-synuclein signaling and Neuroscience. GO annotations related to this gene include protein homodimerization activity and receptor binding.

UniProtKB/Swiss-Prot for PARK7 Gene

  • Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957).

Gene Wiki entry for PARK7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARK7 Gene

Genomics for PARK7 Gene

Regulatory Elements for PARK7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PARK7 Gene

Chromosome:
1
Start:
7,954,291 bp from pter
End:
7,985,505 bp from pter
Size:
31,215 bases
Orientation:
Plus strand

Genomic View for PARK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARK7 Gene

Proteins for PARK7 Gene

  • Protein details for PARK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99497-PARK7_HUMAN
    Recommended name:
    Protein deglycase DJ-1
    Protein Accession:
    Q99497
    Secondary Accessions:
    • B2R4Z1
    • O14805
    • Q6DR95
    • Q7LFU2

    Protein attributes for PARK7 Gene

    Size:
    189 amino acids
    Molecular mass:
    19891 Da
    Cofactor:
    Note=Does not require glutathione as a cofactor, however, glycated glutathione constitutes a PARK7 substrate.;
    Quaternary structure:
    • Homodimer (PubMed:12851414, PubMed:12796482, PubMed:12855764). Binds EFCAB6/DJBP and PIAS2 (PubMed:11477070, PubMed:12851414, PubMed:12612053). Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (PubMed:12612053). Interacts (via N-terminus) with OTUD7B (PubMed:21097510). Interacts with BBS1, HIPK1, CLCF1 and MTERF (PubMed:16390825, PubMed:21097510). Forms a complex with PINK1 and PARK2 (PubMed:19229105).

    Three dimensional structures from OCA and Proteopedia for PARK7 Gene

neXtProt entry for PARK7 Gene

Proteomics data for PARK7 Gene at MOPED

Post-translational modifications for PARK7 Gene

  • Cys-106 is easily oxidized to sulfinic acid.
  • Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for cell-growth promoting activity and transforming activity.
  • Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress.
  • Ubiquitination at Lys 99 and Lys 148
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PARK7 (DJ-1)

No data available for DME Specific Peptides for PARK7 Gene

Domains & Families for PARK7 Gene

Gene Families for PARK7 Gene

Protein Domains for PARK7 Gene

Suggested Antigen Peptide Sequences for PARK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99497

UniProtKB/Swiss-Prot:

PARK7_HUMAN :
  • Belongs to the peptidase C56 family.
Family:
  • Belongs to the peptidase C56 family.
genes like me logo Genes that share domains with PARK7: view

Function for PARK7 Gene

Molecular function for PARK7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=173.4 uM for casein {ECO:0000269 PubMed:20304780}; KM=0.44 mM for glycated N-acetylarginine (at pH 7.0 and 22 degrees Celsius) {ECO:0000269 PubMed:25416785}; KM=0.35 mM for glycated N-acetyllysine (at pH 7.0 and 22 degrees Celsius) {ECO:0000269 PubMed:25416785}; KM=0.32 mM for glycated N-acetylcysteine (at pH 7.0 and 22 degrees Celsius) {ECO:0000269 PubMed:25416785}; Note=kcat is 0.27 sec(-1) for the deglycation of glycated N- acetylarginine. kcat is 0.28 sec(-1) for the deglycation of glycated N-acetyllysine. kcat is 0.42 sec(-1) for the deglycation of glycated N-acetylcysteine. {ECO:0000269 PubMed:25416785};
UniProtKB/Swiss-Prot Function:
Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957).
UniProtKB/Swiss-Prot Induction:
By hydrogen peroxide and UV irradiation.

Enzyme Numbers (IUBMB) for PARK7 Gene

Gene Ontology (GO) - Molecular Function for PARK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 NOT core promoter binding IC 15790595
GO:0003690 NOT double-stranded DNA binding IDA 22683601
GO:0003697 NOT single-stranded DNA binding IDA 22683601
GO:0003713 transcription coactivator activity TAS 16731528
GO:0003729 mRNA binding IDA 18626009
genes like me logo Genes that share ontologies with PARK7: view
genes like me logo Genes that share phenotypes with PARK7: view

Animal Models for PARK7 Gene

MGI Knock Outs for PARK7:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PARK7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PARK7 Gene

Localization for PARK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARK7 Gene

Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. {ECO:0000269 PubMed:14705119, ECO:0000269 PubMed:18711745}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARK7 Gene COMPARTMENTS Subcellular localization image for PARK7 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 3
endoplasmic reticulum 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PARK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 16731528
GO:0005634 nucleus IDA 11477070
GO:0005737 cytoplasm IDA 12446870
GO:0005739 mitochondrion IMP 21785459
GO:0005747 colocalizes_with mitochondrial respiratory chain complex I IDA 19822128
genes like me logo Genes that share ontologies with PARK7: view

Pathways & Interactions for PARK7 Gene

genes like me logo Genes that share pathways with PARK7: view

Pathways by source for PARK7 Gene

1 Sino Biological pathway for PARK7 Gene
1 Qiagen pathway for PARK7 Gene
2 Cell Signaling Technology pathways for PARK7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PARK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IGI 15983381
GO:0001963 synaptic transmission, dopaminergic --
GO:0006469 negative regulation of protein kinase activity IGI 15983381
GO:0006508 proteolysis IEA --
GO:0006517 protein deglycosylation IDA 25416785
genes like me logo Genes that share ontologies with PARK7: view

No data available for SIGNOR curated interactions for PARK7 Gene

Drugs & Compounds for PARK7 Gene

(9) Drugs for PARK7 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 2814
Levodopa Approved Pharma Agonist 339
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Double Oxidized Cysteine Experimental Pharma Target 0
E 64d Pharma Cysteine protease inhibitor, Cathepsin inhibitor; interferes with autolysosomal digestion 0

(9) Additional Compounds for PARK7 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-hydroxydopamine
  • 2,4,5-Trihydroxyphenethylamine
  • 5-(2-Aminoethyl)-1,2,4-benzenetriol
  • 6-Hydroxy-Dopamine
  • 6-Hydroxydopamine
  • Topamine
1199-18-4
Cycloheximide
H2O2
Oligonucleotide
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with PARK7: view

Transcripts for PARK7 Gene

Unigene Clusters for PARK7 Gene

Parkinson protein 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PARK7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARK7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8:

Relevant External Links for PARK7 Gene

GeneLoc Exon Structure for
PARK7
ECgene alternative splicing isoforms for
PARK7

Expression for PARK7 Gene

mRNA expression in normal human tissues for PARK7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARK7 Gene



SOURCE GeneReport for Unigene cluster for PARK7 Gene Hs.419640

mRNA Expression by UniProt/SwissProt for PARK7 Gene

Q99497-PARK7_HUMAN
Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa.
genes like me logo Genes that share expression patterns with PARK7: view

Protein tissue co-expression partners for PARK7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PARK7 Gene

Orthologs for PARK7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PARK7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARK7 35
  • 89.59 (n)
  • 96.3 (a)
PARK7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARK7 35
  • 89.77 (n)
  • 95.77 (a)
PARK7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Park7 35
  • 84.3 (n)
  • 91.53 (a)
Park7 16
Park7 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Park7 35
  • 84.3 (n)
  • 91.53 (a)
oppossum
(Monodelphis domestica)
Mammalia PARK7 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARK7 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARK7 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARK7 35
  • 79.37 (n)
  • 89.95 (a)
DJ-1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARK7 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia park7 35
  • 71.78 (n)
  • 77.25 (a)
Str.15245 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11413 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15530 35
park7 35
  • 71.6 (n)
  • 83.07 (a)
park7 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9560 35
fruit fly
(Drosophila melanogaster)
Insecta DJ-1alpha 35
  • 54.68 (n)
  • 56.74 (a)
DJ-1alpha 36
  • 47 (a)
OneToMany
dj-1beta 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea djr-1.1 35
  • 57.3 (n)
  • 54.05 (a)
djr-1.1 36
  • 52 (a)
OneToMany
djr-1.2 36
  • 44 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G53280 35
  • 50 (n)
  • 44.32 (a)
rice
(Oryza sativa)
Liliopsida Os06g0531200 35
  • 48.4 (n)
  • 41.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC22E12.03c 35
  • 47.11 (n)
  • 35.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for PARK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARK7 Gene

ENSEMBL:
Gene Tree for PARK7 (if available)
TreeFam:
Gene Tree for PARK7 (if available)

Paralogs for PARK7 Gene

Pseudogenes.org Pseudogenes for PARK7 Gene

genes like me logo Genes that share paralogs with PARK7: view

No data available for Paralogs for PARK7 Gene

Variants for PARK7 Gene

Sequence variations from dbSNP and Humsavar for PARK7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs161800 -- 7,982,342(+) AAAAA(A/T)TAAAG intron-variant
rs161801 -- 7,982,676(+) CTGTC(A/G)CTCTG intron-variant
rs161802 -- 7,982,766(+) ATTAT(G/T)ATAAA intron-variant
rs161807 -- 7,977,436(+) ATTTT(A/G)AAGAA intron-variant
rs161808 -- 7,975,654(-) CAGGA(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARK7 Gene

Variant ID Type Subtype PubMed ID
nsv871360 CNV Gain 21882294
nsv1521 CNV Insertion 18451855

Variation tolerance for PARK7 Gene

Residual Variation Intolerance Score: 59.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARK7 Gene

HapMap Linkage Disequilibrium report
PARK7
Human Gene Mutation Database (HGMD)
PARK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARK7 Gene

Disorders for PARK7 Gene

MalaCards: The human disease database

(15) MalaCards diseases for PARK7 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease 7, autosomal recessive early-onset
  • parkinson disease 7
park7-related parkinson disease
  • dj-1-related parkinson disease
amyotrophic lateral sclerosis-parkinsonism/dementia complex
  • amyotrophic lateral sclerosis-parkinsonism/dementia complex, susceptibility to
young-onset parkinson disease
  • early-onset parkinson disease
parkinson disease 10
- elite association
Search PARK7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PARK7_HUMAN
  • Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). {ECO:0000269 PubMed:12446870, ECO:0000269 PubMed:12953260, ECO:0000269 PubMed:15254937, ECO:0000269 PubMed:15365989}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PARK7

Genetic Association Database (GAD)
PARK7
Human Genome Epidemiology (HuGE) Navigator
PARK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARK7
genes like me logo Genes that share disorders with PARK7: view

No data available for Genatlas for PARK7 Gene

Publications for PARK7 Gene

  1. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. (PMID: 9070310) Nagakubo D. … Ariga H. (Biochem. Biophys. Res. Commun. 1997) 2 23 67
  2. BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity. (PMID: 20156966) Deeg S. … Kermer P. (J. Cell Biol. 2010) 23 67
  3. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. (PMID: 20186336) Krebiehl G. … Kruger R. (PLoS ONE 2010) 23 67
  4. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. (PMID: 19680261) Giaime E. … Alves da Costa C. (Cell Death Differ. 2010) 23 67
  5. DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. (PMID: 20133695) Aleyasin H. … Park D.S. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67

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