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PARK7 Gene

protein-coding   GIFtS: 71
GCID: GC01P008014

Parkinson Protein 7

(Previous names: Parkinson disease (autosomal recessive, early onset) 7)
  See PARK7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Parkinson Protein 71 2     HEL-S-67p2
Parkinson Disease (Autosomal Recessive, Early Onset) 71 2     Epididymis Secretory Sperm Binding Protein Li 67p2
Oncogene DJ12 3     Protein DJ-12
DJ12 5     EC 3.4.-.-3
DJ-12     Parkinson Disease Protein 73

External Ids:    HGNC: 163691   Entrez Gene: 113152   Ensembl: ENSG000001162887   OMIM: 6025335   UniProtKB: Q994973   

Export aliases for PARK7 gene to outside databases

Previous GC identifers: GC01U990455 GC01P007830 GC01P007618 GC01P007731 GC01P007956 GC01P007944 GC01P007169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PARK7 Gene:
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of
androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for
oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this
gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the
same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PARK7 Gene:
PARK7 (parkinson protein 7) is a protein-coding gene. Diseases associated with PARK7 include park7-related parkinson disease, and parkinson disease 7, autosomal recessive early-onset. GO annotations related to this gene include peptidase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and
neuronal cells

Gene Wiki entry for PARK7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARK7 gene promoter:
         PPAR-gamma1   POU2F1   SREBP-1a   AML1a   POU2F1a   SREBP-1c   PPAR-gamma2   Pax-4a   SREBP-1b   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARK7 promoter sequence
   Search Chromatin IP Primers for PARK7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

PARK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P008014:  view genomic region     (about GC identifiers)

Start:
8,014,351 bp from pter      End:
8,045,565 bp from pter
Size:
31,215 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497 (See protein sequence)
Recommended Name: Protein DJ-1 precursor  
Size: 189 amino acids; 19891 Da
Subunit: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.
Interacts (via N-terminus) with OTUD7B. Interacts with BBS1, HIPK1, CLCF1 and MTERF
Selected PDB 3D structures from and Proteopedia for PARK7 (see all 27):
1J42 (3D)        1P5F (3D)        1PDV (3D)        1PDW (3D)        1PE0 (3D)        1Q2U (3D)    
Secondary accessions: B2R4Z1 O14805 Q6DR95 Q7LFU2

Explore the universe of human proteins at neXtProt for PARK7: NX_Q99497

Explore proteomics data for PARK7 at MOPED

Post-translational modifications: 

  • Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for
    cell-growth promoting activity and transforming activity1
  • Cys-106 is easily oxidized to sulfinic acid1
  • Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative
    stress1
  • Ubiquitination2 at Lys41, Lys99, Lys148
  • Modification sites at PhosphoSitePlus

  • See PARK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116849.1  NP_009193.2  

    ENSEMBL proteins: 
     ENSP00000465404   ENSP00000340278   ENSP00000418770   ENSP00000466242   ENSP00000366711  
     ENSP00000366708   ENSP00000466756  

    PARK7 Human Recombinant Protein Products:

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    Novus Biologicals PARK7 Proteins
    Novus Biologicals PARK7 Lysates
    Sino Biological Recombinant Protein for PARK7
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PARK7
    Cloud-Clone Corp. Proteins for PARK7

     
    Search eBioscience for Proteins for PARK7 

     
    antibodies-online proteins for PARK7 (26 products) 

     
    antibodies-online peptides for PARK7

    PARK7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARK7
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    antibodies-online antibodies for PARK7 (175 products) 

    PARK7 Assay Products:

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    GenScript Custom Assay Services for PARK7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PARK7
    Cloud-Clone Corp. CLIAs for PARK7
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    antibodies-online kits for PARK7 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARK: Parkinson disease

    2 InterPro protein domains:
     IPR006287 DJ1
     IPR002818 ThiJ/PfpI

    Graphical View of Domain Structure for InterPro Entry Q99497

    ProtoNet protein and cluster: Q99497

    1 Blocks protein domain: IPB002818 Family of unknown function ThiJ/PfpI

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Similarity: Belongs to the peptidase C56 family


    Find genes that share domains with PARK7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARK7_HUMAN, Q99497
    Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or
    stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the
    substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via
    L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen
    peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen
    peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective
    action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and
    its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear
    translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits
    their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and
    function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a
    positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in
    fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May
    function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and
    neuronal cells
    Biophysicochemical properties: Kinetic parameters: KM=173.4 uM for casein;
    Induction: By hydrogen peroxide and UV irradiation

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA18626009
    GO:0004601peroxidase activity ISS--
    GO:0005515protein binding IPI11477070
    GO:0008233peptidase activity IDA--
    GO:0042803protein homodimerization activity IDA18711745
         
    Find genes that share ontologies with PARK7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PARK7:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Park7):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with PARK7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PARK7: Park7tm1Cai Park7tm1Tmd Park7tm1Xz Park7tm1Shn Park7tm1Dsp

       genOway: Develop your customized and physiologically relevant rodent model for PARK7

    miRNA
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    miRTarBase miRNAs that target PARK7:
    hsa-mir-92b-3p (MIRT040717), hsa-mir-222-3p (MIRT046823), hsa-mir-92a-3p (MIRT049137), hsa-mir-26b-5p (MIRT029955)

    Block miRNA regulation of human, mouse, rat PARK7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PARK7
    SwitchGear 3'UTR luciferase reporter plasmidPARK7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PARK7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PARK7

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PARK7 (NM_007262)
    Sino Biological Human cDNA Clone for PARK7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARK7
    Addgene plasmids for PARK7 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PARK7_HUMAN, Q99497: Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Note=Under
    normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and
    mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress
    and exerts an increased cytoprotective effect against oxidative damage. Detected in tau inclusions in brains from
    neurodegenerative disease patients. Membrane raft localization in astrocytes and neuronal cells requires
    palmitoylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11477070
    GO:0005737cytoplasm IDA12446870
    GO:0005739mitochondrion IMP--
    GO:0005829cytosol IMP--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with PARK7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARK7 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    2Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    3TNF Signaling
    Death Receptor Signaling0.50
    4CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31
    5PI3K / Akt Signaling
    PI3K / Akt Signaling


    Find genes that share SuperPaths with PARK7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PARK7
        Parkinson's Disease Pathway

    2 Cell Signaling Technology (CST) Pathways for PARK7
        Neuroscience
    PI3K / Akt Signaling

    4 BioSystems Pathways for PARK7
        Parkinsons Disease Pathway
    Androgen receptor signaling pathway
    Synaptic Vesicle Pathway
    Alpha-synuclein signaling

    1 Sino Biological Pathway for PARK7
        Death Receptor Signaling


    1 Kegg Pathway  (Kegg details for PARK7):
        Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PARK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARK7 (Q994971, 2, 3 ENSP000003402784) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206206Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000206279Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000227046Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    ENSG00000231617Q9UER71, 3EBI-1164361,EBI-77321 I2D: score=2 
    MTA2O947761, 3, ENSP000002788234EBI-1164361,EBI-1783035 I2D: score=2 STRING: ENSP00000278823
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ----
    GO:0006508proteolysis ----
    GO:0006914autophagy IEA--
    GO:0006954inflammatory response IEA--
    GO:0007005mitochondrion organization ISS--

    Find genes that share ontologies with PARK7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PARK7

    1 DrugBank Compound for PARK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Double Oxidized Cysteine-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for PARK7 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    e 64d 76.3 9 15365989 (3), 17451229 (1), 20186336 (1), 15663963 (1)
    sulfinic acid 59.7 3 16403519 (2), 16181642 (1)
    rotenone 56 8 18377993 (3), 16439141 (2), 16854843 (2), 18930142 (1)
    6-hydroxydopamine 51.9 8 18377993 (3), 18974921 (1), 16860563 (1), 16227205 (1) (see all 5)
    dopamine 46.9 33 16978583 (4), 18974921 (4), 19703902 (3), 16227205 (2) (see all 9)
    cysteine 34.6 35 16316629 (3), 19124468 (2), 16935423 (2), 18570440 (2) (see all 13)
    h2o2 30.8 20 16935423 (2), 15081400 (2), 20046643 (2), 14652021 (1) (see all 10)
    levodopa 29.9 1 19703902 (1)
    oxygen 17.5 13 16403519 (1), 16115732 (1), 18430896 (1), 15219840 (1) (see all 12)
    pyrimidine 14.5 4 16731528 (2), 15790595 (1), 18689799 (1)



    Find genes that share compounds with PARK7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PARK7 gene (2 alternative transcripts): 
    NM_001123377.1  NM_007262.4  

    Unigene Cluster for PARK7:

    Parkinson protein 7
    Hs.419640  [show with all ESTs]
    Unigene Representative Sequence: BF965121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493373 ENST00000460192 ENST00000338639(uc001aou.4 uc001aox.4 uc001aov.4)
    ENST00000493678 ENST00000377493 ENST00000465354 ENST00000377491 ENST00000377488
    ENST00000497113 ENST00000469225
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat PARK7

    Additional mRNA sequence: 

    AB073864.1 AF021819.1 AK130886.1 AK312000.1 BC008188.2 D61380.2 

    Selected DOTS entries (see all 30):

    DT.100864956  DT.448826  DT.91912005  DT.100864954  DT.100864946  DT.99944190  DT.91858715  DT.100723157 
    DT.121340910  DT.95171052  DT.100864949  DT.100864951  DT.100864952  DT.95171053  DT.91717622  DT.95171037 
    DT.100864945  DT.100864955  DT.121340885  DT.121340900  DT.121340908  DT.121340933  DT.121340949  DT.91778970 

    818 AceView cDNA sequences (see top 24):

    AA251345 AI202676 BM760109 BM750124 BM756505 C05103 AL556933 CB996016 
    CR623919 AJ709120 BM741700 CR591123 CD050392 AI761742 BM759196 CD672896 
    BM704825 BM824731 BQ028408 BM760888 BM760169 AA602784 BU657605 AA039588 
    AA670002 BM910109 BM852110 BQ437995 F26009 BM707721 F31941 BM454284 
    BX324483 AA312271 H95132 BM739800 BM771807 BM739440 BM670136 CR618546 
    BU730460 AA535605 BM835995 BQ052914 Z41594 BF038857 CD673038 F20533 
    AA315948 BF037742 BM914964 BM709072 BU733245 BM853389 T30497 BM757918 
    AI340291 BQ643180 BI085219 BG113506 BM712090 BU533141 AK091679 AX747125 
    T34178 AA315511 BI830621 BM771936 BM756396 BM771887 AI340289 BE794210 
    BM760096 BU167723 AI174859 BQ436114 D61380 BM792160 BM760893 AV704886 
    CD047909 BE550383 BM970518 BM663446 AI042422 BM908816 CB146358 BU159556 
    AA773602 BI712058 AI291271 BM738949 AA360496 AA782060 BM685534 BM504242 
    AI340293 BU194430 BM771427 BU731851 AA857890 BM565556 BM507294 AW327656 
    BQ689827 BP870566 AA621820 BQ431243 BQ716403 BM464399 BM985360 BI856917 
    BM825330 BG754603 W67123 AA039589 AI870594 BF002713 BM771392 BU595800 
    BM740026 AA576779 CF128271 CB106548 CB108284 BM760078 BM466509 BU682926 
    BM832829 BI713009 BM972739 AA908891 BE515210 BF094931 BU521162 BI826586 
    BM784009 BQ448057 BU507463 BM700123 AL558174 BM014914 BQ953110 CR616157 
    AA664387 BQ030064 CR623768 AA745919 BQ420525 AA338326 BM760127 BM759942 
    BG397729 CB990976 BM758413 BM738685 CB986032 AJ572206 BE747390 BI752414 
    AA334247 BU508809 BF663568 BG036516 BG547400 BM825036 AI608749 BU941957 
    BG113413 BM754747 CB135857 BU655916 BI552690 BM759779 AW327341 BM974673 
    BG542982 BG574615 BE786592 BE612711 BM554785 AI660534 CD247911 BG778103 
    BM833037 BI669109 BM469775 BM761128 AA360248 CB305962 BE904866 CD384909 
    BG563173 BE882274 BM838051 BF670759 BM549447 BI468196 BX444623 BU942782 
    CD104643 AK130886 CD050202 BG616740 AA649975 N78638 BM750026 CF130154 
    BP345841 BG705972 D61243 BM764367 BE734171 R78197 AW248378 AB073864 
    BQ928255 AI564730 AA082613 BQ212397 BG756205 BM747812 BM752044 AI023091 
    BM691038 BI860650 BM739007 BU945447 BG773967 T30771 CB994570 BM271944 
    F22363 BM677199 CD367391 BI862167 BI599015 AA770265 BM806720 BU603303 
    BP373347 BG216416 BX324480 CB107062 BV174154 CB114202 BM264575 NM_007262 
    BE542498 BM997585 BM785713 D80701 BF033416 BG423342 F32879 BQ230427 
    BG770239 BG501575 CA868472 BG750611 AI342421 AI936972 BF979558 BX324482 
    AV745458 F36909 AJ346332 CF130579 BP369862 BM751890 AA188297 BU657225 
    AA339292 BG341878 AI302083 CB108324 BQ212897 CB111342 BE740170 CB139182 
    BQ430301 BI858850 BE622126 BE386433 BF984854 BI549623 CB044395 BU148556 
    BM770994 CF126312 CA848524 CF597299 BU660390 AI673204 AA670451 BE729243 
    BG194659 AA430079 BG616245 CB113686 AI741250 BG617951 CB997655 BU752245 
    Z45982 BG336215 BM767095 BG757388 BG424977 W68839 BE257972 BI457686 
    BG618364 BM739418 BU687752 BG616612 BQ421876 BQ887259 BU193062 BU630080 
    CB991918 AI299226 BU527611 BF979943 BM020637 BI492331 BM721574 AA305373 
    BM043362 BG527698 BM740234 W16665 BM313054 BU656177 BU660800 BQ648712 
    CF128206 BM973909 C03009 AI147833 BF792275 BI770788 AI089754 BU849447 
    BG564822 BM781506 BU178542 BU688129 BM313333 BF794080 BF244130 T35586 
    T35472 CA309297 CA867705 W42604 BF680243 AA101116 BE873735 BG027551 
    BG771654 BE729401 AI750074 BE044936 BM770984 BG190934 BE884370 BP342698 
    BM841559 BU189074 BF036842 BG183715 CF128522 AV734385 BM475943 AF021819 
    BM834633 BM547712 BQ640074 BM771443 BM739429 BP870464 BF663649 BU596224 
    AA359577 CB108094 BQ337743 AL523595 CA411878 BM841748 BX324481 BU589696 
    BM504459 CB108934 BM832175 BG530596 BM696948 BQ436065 BU660583 BM476270 
    BG503232 BE256566 CD520814 BM450448 BU659430 BE514925 BM745717 BC008188 
    AV714584 AW406425 BF758569 BG715880 BU600022 BG027271 BE409907 AI479785 
    BU596513 BI858857 BG401600 BF340167 CB147694 BE253104 BM754733 AL556806 
    BM797575 BG610692 BM978273 BM760787 BE408488 BX400386 CB997439 BM453371 
    CB112661 AA969401 AI205219 AA927139 BG121158 BF979202 BU660943 AA969322 
    BI092098 BU603047 BM759978 CR619796 C05602 CA413329 BF968416 BE280484 
    AA569602 BG473010 AI051570 BU660931 BE714792 BM473249 BG505648 CB110305 
    BU932550 BU933538 T61971 BI259158 CB994113 BU186540 F03427 AV701044 
    CD369322 CA437228 BG564854 W69749 CB130655 AA502953 BP430704 BG622377 
    T35410 BF697565 AI830287 AW955128 BG716033 T30680 BU656249 CB995456 
    BG941195 BG108953 N56354 BE958231 BG496051 AA148486 AV736486 T30413 
    D80951 CB994921 BF959953 BI257537 BF244004 AV685152 AA219044 BF304756 
    BG480113 BG182169 AA055453 BQ953086 C03334 AA055454 CD623973 BU165447 
    BG567095 BQ694844 AW651676 CD707231 BM840620 BF681557 AW021299 W46765 
    BG401990 D61761 AA587727 BM747356 CD703086 BG505547 CD698540 AV711323 
    BQ376649 CA453781 BM991452 AA716183 AA569496 BU664329 BI549393 AA129779 
    BI085865 BE896092 AI190063 BU683903 BI457646 AI349300 BM833215 BU661538 
    CB956553 AV759648 BM840613 BU933082 AL597220 BG207529 AA574416 BG179920 
    BE782528 BM743588 CB321705 AI052100 BF305543 AL597221 BF796819 BM691397 
    CD703195 AW673137 CD707706 H41623 AI031586 BP428853 BF003013 BF978875 
    N81066 BF678748 BQ953241 CB958261 BF184620 AA310134 AI767860 BI194256 
    BG219128 AI243399 BG109435 BF681354 AI498521 BU659448 BM476996 BU657451 
    D80458 BU658230 CA777472 BM990268 BG500728 BE562354 AI247773 D61064 
    BG200274 CD110216 CF527958 BI602006 AA329174 BG202862 BE567765 AV745502 
    N77240 BM748951 F07139 D79762 D53132 BG393962 BG230501 BX351075 
    AI034225 AA733210 BF476745 CD641373 AV744394 BQ934466 AW380211 BG484602 
    AW380197 AA216242 AA228370 BF216838 F32888 BM797379 CD689853 D79337 
    BG498240 CK001102 F30887 AA228859 D52382 BE928232 BG200275 BU074477 
    BP349001 BF242793 F27456 W42607 T61908 BM465181 AV753003 AV745904 
    BU074761 AI034421 BI468195 AI034314 CD298828 BG029568 AV763748 BF382373 
    AV716113 AV701247 AW607029 AV701087 CD701374 CB107597 CD692502 T29930 
    AJ346410 BM739882 BE827551 AV722182 D53083 BG256228 BF126090 AW806383 
    AI983345 AV745893 AV695518 CD706643 AV745522 BF094973 CD696942 AL558173 
    AV746418 AV691510 CB991322 CD691001 BE928219 BF700328 W31890 BF170373 
    BU566510 AV736392 W07496 T35587 R51981 H42326 BM045884 CD623974 
    AV745614 AA251440 BE833667 C04479 BE440017 BQ347810 BF341610 AJ574003 
    AA481957 BE961136 AW206383 CA777735 BF798908 AA376344 D53402 CD520724 
    BF758566 BE622939 BF675687 BF907444 AU099598 BG422859 BG757311 BE870483 
    AV753888 H24532 T35662 BE047815 BF571111 BG213865 BX106037 D61300 
    BU595868 BU589551 BI860373 BE177604 AV757884 D81267 D81438 BF907442 
    CD106479 C17909 AW793435 AV701341 BM787501 CD702892 BE568546 BG112406 
    BM987677 BG202303 AA219196 D81357 CD110428 BM476682 BU944919 CA842038 
    BM503757 BF086088 BQ230393 BU600587 AW904199 AI149327 BF837367 AA308838 
    AV753975 BQ377065 BG219621 AI189013 BG210698 BG471144 BU953513 CB961441 
    AV692049 BF094970 AA947522 W69856 BF965368 BF907427 D60929 BF693327 
    AI707820 BU179010 AW806434 AW800369 CD522098 AV722608 BQ435677 BF306402 
    BE258993 BF336957 H38029 D58737 AL582600 D81330 BI827423 BM509906 
    BM907005 AV707572 CD247024 BM754224 BF841538 CD521754 AW170613 AA186809 
    AA019415 BF907424 BF675780 AV700974 BF907437 H42923 BF745980 AW806398 
    BF175519 BE767842 BX394683 BE970959 BF094947 AW810585 BQ428860 BQ317990 
    R11782 BU596849 CD251159 BQ312553 AW674240 AW967133 BE826121 BU168051 
    BF335901 BF907431 CA841746 BQ307988 BF751458 BG026601 AI206790 AA092956 
    BE899270 BG185293 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PARK7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -     -     -     -                                         -     -                                 
    SP2:                          -     -     -                                         -     -                                 
    SP3:                                                                                -     -                                 
    SP4:                    -     -     -     -                 -     -                 -     -                                 
    SP5:                                      -                                         -     -                                 


    ECgene alternative splicing isoforms for PARK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PARK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAGGTTT
    PARK7 Expression
    About this image


    PARK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PARK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARK7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419640

    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
    Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at
    slightly lower levels in placenta and brain. Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and
    spermatozoa

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARK7: 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PARK7
    OriGene qSTAR qPCR primer pairs in human, mouse for PARK7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PARK7
    QuantiTect SYBR Green Assays in human, mouse, rat PARK7
    QuantiFast Probe-based Assays in human, mouse, rat PARK7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PARK7 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Park71 , 5 Parkinson disease (autosomal recessive, early onset) more1, 5 84.3(n)1
    91.53(a)1
      4 (81.52 cM)5
    573201  NM_020569.31  NP_065594.21 
     1508971335 
    chicken
    (Gallus gallus)
    Aves PARK71 Parkinson disease (autosomal recessive, early onset) more 79.37(n)
    89.95(a)
      395277  NM_204585.1  NP_989916.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARK76
    parkinson protein 7
    86(a)
    1 ↔ 1
    GL344178.1(17994-24787)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114132 Xenopus laevis SP22 mRNA, complete cds 77.13(n)    AF394958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.155302 Transcribed sequence with moderate similarity to protein more 74.28(n)    BM317196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DJ-1alpha1 DJ-1alpha 54.68(n)
    56.74(a)
      36543  NM_137072.1  NP_610916.1 
    worm
    (Caenorhabditis elegans)
    Secernentea djr-1.11 djr-1.1 57.3(n)
    54.05(a)
      173416  NM_061295.6  NP_493696.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G532801 AT1G53280 50(n)
    44.32(a)
      841762  NM_104206.3  NP_564626.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g05312001 Os06g0531200 48.4(n)
    41.81(a)
      4341205  NM_001064318.1  NP_001057783.2 


    ENSEMBL Gene Tree for PARK7 (if available)
    TreeFam Gene Tree for PARK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARK7 gene

    Find genes that share paralogs with PARK7           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PARK7
    PGOHUM00000239770 PGOHUM00000236716


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PARK7 (see all 593)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743153521,2,,4
    C,FParkinson disease 7 (PARK7)4 pathogenic18062522(+) AAAAGA/CCGGCC 4 D A mis11Minor allele frequency- C:0.00NA 4552
    rs289381721,2,,4
    CParkinson disease 7 (PARK7)4 pathogenic18062573(+) TGCGCC/TTGCAA 4 P L mis10--------
    VAR_0204934
    Parkinson disease 7 (PARK7)4--see VAR_0204932 E D mis40--------
    VAR_0204924
    Parkinson disease 7 (PARK7)4--see VAR_0204922 M I mis40--------
    VAR_0204954
    Parkinson disease 7 (PARK7)4--see VAR_0204952 A T mis40--------
    rs743153511,2
    Cpathogenic18040457(+) GTCATA/GAGGCG 4 I M mis10--------
    rs743153531,2
    Cpathogenic18043019(+) AAAGAC/GGTTTG 4 D E mis10--------
    rs355406561,2
    C--8029645(+) CAAAC-/TTTTTTT 2 -- int10--------
    rs1859284181,2
    --8037254(+) CCACTA/GTGGAA 2 -- us2k10--------
    rs1906380831,2
    --8037549(+) CTCGAA/GAGACT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PARK7 (8014351 - 8045565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PARK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1521CNV Insertion18451855
    nsv871360CNV Gain21882294

    Human Gene Mutation Database (HGMD): PARK7
    Locus Specific Mutation Databases (LSDB): PARK7

    1 Site Specific Mutation Identification with PCR Assay for PARK7:
    Cosmic IdAA Change
    98000118
    SeqTarget long-range PCR primers for resequencing PARK7
    DNA2.0 Custom Variant and Variant Library Synthesis for PARK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602533   
    OMIM disorders: 606324  
    UniProtKB/Swiss-Prot: PARK7_HUMAN, Q99497
  • Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor,
    postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40
    years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of
    amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 7 diseases for PARK7:    
    About MalaCards
    park7-related parkinson disease    parkinson disease 7, autosomal recessive early-onset    amyotrophic lateral sclerosis-parkinsonism/dementia complex    spinocerebellar ataxia type 17
    parkinson's disease    parkinson disease 1    amyotrophic lateral sclerosis

    1 disease from the University of Copenhagen DISEASES database for PARK7:
    Parkinson's disease

    Find genes that share disorders with PARK7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PARK7 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 89.2 181 20157014 (6), 14662519 (5), 15219840 (4), 14707326 (3) (see all 99)
    autosomal recessive parkinsonism 87.5 12 14638971 (3), 19429112 (2), 17914725 (1), 19297401 (1) (see all 7)
    parkinsonism 85.4 87 19429112 (5), 15565491 (2), 19124468 (2), 15542239 (2) (see all 47)
    parkinsonism juvenile autosomal recessive 81 10 14652021 (1), 14745011 (1), 17268184 (1), 19243613 (1) (see all 8)
    parkinson disease, autosomal dominant 76.4 2 15717024 (1)
    neurodegenerative diseases 74.9 18 19686841 (2), 14705119 (2), 17719794 (2), 18930142 (1) (see all 12)
    neurodegeneration 65.1 11 14712351 (2), 19023331 (1), 16115732 (1), 16439141 (1) (see all 9)
    movement disorders 64 1 18704525 (1)
    tauopathies 57.9 8 14991385 (2), 15935068 (1), 17085780 (1), 14705119 (1)
    lewy body disease 38.6 1 14625045 (1)

    GeneTests: PARK7
    GeneReviews: PARK7
    Genetic Association Database (GAD): PARK7
    Human Genome Epidemiology (HuGE) Navigator: PARK7 (24 documents)

    Export disorders for PARK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PARK7 gene, integrated from 10 sources (see all 417):
    (articles sorted by number of sources associating them with PARK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. (PubMed id 14872018)1, 2, 4, 9 Hedrich K.... Klein C. (Neurology 2004)
    2. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. (PubMed id 9070310)1, 2, 3, 9 Nagakubo D.... Ariga H. (Biochem. Biophys. Res. Commun. 1997)
    3. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. (PubMed id 18711745)1, 2, 9 Junn E.... Mouradian M.M. (J. Neurosci. Res. 2009)
    4. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. (PubMed id 14662519)1, 2, 9 Bandopadhyay R.... Lees A.J. (Brain 2004)
    5. DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. (PubMed id 16390825)1, 2, 9 Sekito A....Ariga H. (Free Radic. Res. 2006)
    6. The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. (PubMed id 12855764)1, 2, 9 Wilson M.A.... Petsko G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo- oligomerization. (PubMed id 14713311)1, 2, 9 Moore D.J.... Dawson V.L. (J. Neurochem. 2003)
    8. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. (PubMed id 12914946)1, 2, 9 Huai Q.... Ke H. (FEBS Lett. 2003)
    9. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. (PubMed id 11223268)1, 2, 9 Taira T.... Ariga H. (Gene 2001)
    10. Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism. (PubMed id 19429112)1, 4, 9 Tomiyama H....Hattori N. (Neurosci. Lett. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11315 HGNC: 16369 AceView: PARK7 Ensembl:ENSG00000116288 euGenes: HUgn11315
    ECgene: PARK7 Kegg: 11315 H-InvDB: PARK7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PARK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PARK7 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PARK7[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=P&genename=PARK7+%40+DJ-1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PARK7 gene:
    Search GeneIP for patents involving PARK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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