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Aliases for PARD6G Gene

Aliases for PARD6G Gene

  • Par-6 Family Cell Polarity Regulator Gamma 2 3 5
  • PAR6D 3 4
  • Par-6 (Partitioning Defective 6, C.Elegans) Homolog Gamma 2
  • Par-6 Partitioning Defective 6 Homolog Gamma (C. Elegans) 2
  • Par-6 Partitioning Defective 6 Homolog Gamma 3
  • Partitioning Defective 6 Homolog Gamma 3
  • PAR-6 Gamma Protein 3
  • PAR-6 Gamma 4
  • PAR6gamma 3
  • PAR-6G 3
  • PAR6G 4

External Ids for PARD6G Gene

Previous GeneCards Identifiers for PARD6G Gene

  • GC18M077432
  • GC18M077971
  • GC18M077652
  • GC18M076016
  • GC18M076014
  • GC18M075999
  • GC18M077915
  • GC18M074536

Summaries for PARD6G Gene

GeneCards Summary for PARD6G Gene

PARD6G (Par-6 Family Cell Polarity Regulator Gamma) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Cell junction organization. An important paralog of this gene is PARD6B.

UniProtKB/Swiss-Prot for PARD6G Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).

Additional gene information for PARD6G Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD6G Gene

Genomics for PARD6G Gene

Regulatory Elements for PARD6G Gene

Enhancers for PARD6G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H079397 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +845.0 845026 9 HDGF PKNOX1 RB1 SIN3A BATF GLIS2 ATF7 ETV6 RUNX3 CREM NFATC1 ATP9B ADNP2 RBFA PARD6G CTDP1 ENSG00000267287 KCNG2 ENSG00000279637
GH18H080178 1 FANTOM5 ENCODE 5.4 +67.8 67834 2 ZFHX2 TARDBP IKZF1 ATF7 EBF1 DPF2 BATF IKZF2 SPI1 RBFADN ENSG00000267251 ENSG00000267127 PARD6G CTDP1 ENSG00000278000
GH18H080246 1 FANTOM5 ENCODE 4 +1.0 1016 0 MAZ SP3 KLF1 SP2 ZBTB8A ZFHX2 ZNF341 GLIS1 PRDM10 ZBTB26 RBFADN PARD6G PIR31834
GH18H080174 0.5 ENCODE 5.4 +71.6 71578 1 MLLT1 ZIC2 EZH2 FOXA1 RBFADN ENSG00000267251 PARD6G ENSG00000278000
GH18H080247 0.7 ENCODE 0.7 +0.3 319 0 CTCF MXI1 SAP130 ZBTB8A E2F1 GLIS2 POLR2A KLF9 HNF4A PRDM10 PARD6G PIR31834
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARD6G on UCSC Golden Path with GeneCards custom track

Promoters for PARD6G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105421 446 1801 CTCF MXI1 KLF1 RAD21 E2F1 ZFHX2 GLIS2 PRDM10 EZH2 SP3

Genomic Location for PARD6G Gene

Chromosome:
18
Start:
80,157,232 bp from pter
End:
80,247,546 bp from pter
Size:
90,315 bases
Orientation:
Minus strand

Genomic View for PARD6G Gene

Genes around PARD6G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARD6G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARD6G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD6G Gene

Proteins for PARD6G Gene

  • Protein details for PARD6G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG4-PAR6G_HUMAN
    Recommended name:
    Partitioning defective 6 homolog gamma
    Protein Accession:
    Q9BYG4
    Secondary Accessions:
    • A8QM57

    Protein attributes for PARD6G Gene

    Size:
    376 amino acids
    Molecular mass:
    40883 Da
    Quaternary structure:
    • Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ.

    Alternative splice isoforms for PARD6G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARD6G Gene

Post-translational modifications for PARD6G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARD6G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PARD6G Gene

Domains & Families for PARD6G Gene

Gene Families for PARD6G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PARD6G Gene

Suggested Antigen Peptide Sequences for PARD6G Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYG4

UniProtKB/Swiss-Prot:

PAR6G_HUMAN :
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Belongs to the PAR6 family.
Domain:
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
Family:
  • Belongs to the PAR6 family.
genes like me logo Genes that share domains with PARD6G: view

Function for PARD6G Gene

Molecular function for PARD6G Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).

Phenotypes From GWAS Catalog for PARD6G Gene

Gene Ontology (GO) - Molecular Function for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11260256
genes like me logo Genes that share ontologies with PARD6G: view

Phenotypes for PARD6G Gene

genes like me logo Genes that share phenotypes with PARD6G: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARD6G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARD6G Gene

Localization for PARD6G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD6G Gene

Cytoplasm. Cell membrane. Cell junction, tight junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARD6G gene
Compartment Confidence
cytosol 5
plasma membrane 4
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PARD6G: view

Pathways & Interactions for PARD6G Gene

genes like me logo Genes that share pathways with PARD6G: view

Gene Ontology (GO) - Biological Process for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0051301 cell division IEA --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with PARD6G: view

No data available for SIGNOR curated interactions for PARD6G Gene

Drugs & Compounds for PARD6G Gene

(1) Drugs for PARD6G Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PARD6G: view

Transcripts for PARD6G Gene

mRNA/cDNA for PARD6G Gene

Unigene Clusters for PARD6G Gene

Par-6 partitioning defective 6 homolog gamma (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PARD6G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PARD6G Gene

No ASD Table

Relevant External Links for PARD6G Gene

GeneLoc Exon Structure for
PARD6G
ECgene alternative splicing isoforms for
PARD6G

Expression for PARD6G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARD6G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARD6G Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.2) and Skin - Not Sun Exposed (Suprapubic) (x5.7).

Protein differential expression in normal tissues from HIPED for PARD6G Gene

This gene is overexpressed in Adipocyte (39.4) and Heart (29.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARD6G Gene



Protein tissue co-expression partners for PARD6G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARD6G Gene:

PARD6G

SOURCE GeneReport for Unigene cluster for PARD6G Gene:

Hs.654920

mRNA Expression by UniProt/SwissProt for PARD6G Gene:

Q9BYG4-PAR6G_HUMAN
Tissue specificity: Widely expressed, with a higher expression in fetal and adult kidney.

Evidence on tissue expression from TISSUES for PARD6G Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with PARD6G: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PARD6G Gene

Orthologs for PARD6G Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD6G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARD6G 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia PARD6G 33 34
  • 82.57 (n)
dog
(Canis familiaris)
Mammalia PARD6G 33 34
  • 80.7 (n)
rat
(Rattus norvegicus)
Mammalia Pard6g 33
  • 79.41 (n)
mouse
(Mus musculus)
Mammalia Pard6g 33 16 34
  • 77.9 (n)
oppossum
(Monodelphis domestica)
Mammalia PARD6G 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARD6G 33 34
  • 68.66 (n)
lizard
(Anolis carolinensis)
Reptilia PARD6G 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pard6g 33
  • 64.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1701 33
zebrafish
(Danio rerio)
Actinopterygii pard6gb 33 34
  • 66.49 (n)
pard6ga 34
  • 42 (a)
OneToMany
Dr.27686 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010494 33
  • 60.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta par-6 35 33 34
  • 60.22 (n)
worm
(Caenorhabditis elegans)
Secernentea par-6 35 33 34
  • 53.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7159 34
  • 40 (a)
OneToMany
Species where no ortholog for PARD6G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARD6G Gene

ENSEMBL:
Gene Tree for PARD6G (if available)
TreeFam:
Gene Tree for PARD6G (if available)

Paralogs for PARD6G Gene

Paralogs for PARD6G Gene

(3) SIMAP similar genes for PARD6G Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARD6G: view

Variants for PARD6G Gene

Sequence variations from dbSNP and Humsavar for PARD6G Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000002882 -- 80,203,786(+) GAAGT(A/G)TCTTC intron-variant
rs1000008403 -- 80,215,110(+) CTATA(C/T)CCGGC intron-variant
rs1000117690 -- 80,236,614(+) TCTCA(A/G/T)CCCAA intron-variant
rs1000173819 -- 80,220,509(+) CAGTA(C/T)TGTGT intron-variant
rs1000217718 -- 80,239,459(+) TTACC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARD6G Gene

Variant ID Type Subtype PubMed ID
dgv3413n100 CNV gain 25217958
dgv3414n100 CNV gain 25217958
dgv3415n100 CNV gain 25217958
dgv3416n100 CNV gain 25217958
dgv3417n100 CNV loss 25217958
dgv3418n100 CNV gain 25217958
dgv649e214 CNV loss 21293372
esv2661105 CNV deletion 23128226
esv2663498 CNV deletion 23128226
esv2676946 CNV deletion 23128226
esv2678187 CNV deletion 23128226
esv2763194 CNV gain 21179565
esv3410531 CNV duplication 20981092
esv3434904 CNV duplication 20981092
esv3443388 CNV duplication 20981092
esv3574208 CNV gain 25503493
esv3643330 CNV loss 21293372
esv3643331 CNV gain 21293372
esv3643332 CNV loss 21293372
esv3643333 CNV gain 21293372
esv3643335 CNV loss 21293372
esv3643336 CNV loss 21293372
esv3643337 CNV loss 21293372
nsv1062516 CNV gain 25217958
nsv1065653 CNV gain+loss 25217958
nsv1065902 CNV gain 25217958
nsv1145787 CNV deletion 26484159
nsv1151423 CNV deletion 26484159
nsv1160552 CNV duplication 26073780
nsv428359 CNV gain 18775914
nsv458317 CNV gain 19166990
nsv507886 OTHER sequence alteration 20534489
nsv577970 CNV gain 21841781
nsv577971 CNV loss 21841781
nsv953932 CNV deletion 24416366

Variation tolerance for PARD6G Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARD6G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARD6G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARD6G Gene

Disorders for PARD6G Gene

Relevant External Links for PARD6G

Genetic Association Database (GAD)
PARD6G
Human Genome Epidemiology (HuGE) Navigator
PARD6G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARD6G

No disorders were found for PARD6G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARD6G Gene

Publications for PARD6G Gene

  1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PMID: 11260256) Noda Y … Sumimoto H (Genes to cells : devoted to molecular & cellular mechanisms 2001) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PMID: 10934474) Joberty G … Macara IG (Nature cell biology 2000) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for PARD6G Gene

Sources for PARD6G Gene

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