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Aliases for PARD6G Gene

Aliases for PARD6G Gene

  • Par-6 Family Cell Polarity Regulator Gamma 2 3 5
  • PAR6D 3 4
  • Par-6 (Partitioning Defective 6, C.Elegans) Homolog Gamma 2
  • Par-6 Partitioning Defective 6 Homolog Gamma (C. Elegans) 2
  • Par-6 Partitioning Defective 6 Homolog Gamma 3
  • PAR-6 Gamma Protein 3
  • PAR-6 Gamma 4
  • PAR6gamma 3
  • PAR-6G 3
  • PAR6G 4

External Ids for PARD6G Gene

Previous GeneCards Identifiers for PARD6G Gene

  • GC18M077432
  • GC18M077971
  • GC18M077652
  • GC18M076016
  • GC18M076014
  • GC18M075999
  • GC18M077915
  • GC18M074536

Summaries for PARD6G Gene

GeneCards Summary for PARD6G Gene

PARD6G (Par-6 Family Cell Polarity Regulator Gamma) is a Protein Coding gene. Among its related pathways are Axon guidance and Endocytosis. An important paralog of this gene is PARD6A.

UniProtKB/Swiss-Prot for PARD6G Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD6G Gene

Genomics for PARD6G Gene

Regulatory Elements for PARD6G Gene

Promoters for PARD6G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARD6G on UCSC Golden Path with GeneCards custom track

Genomic Location for PARD6G Gene

Chromosome:
18
Start:
80,157,232 bp from pter
End:
80,247,546 bp from pter
Size:
90,315 bases
Orientation:
Minus strand

Genomic View for PARD6G Gene

Genes around PARD6G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARD6G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARD6G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD6G Gene

Proteins for PARD6G Gene

  • Protein details for PARD6G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG4-PAR6G_HUMAN
    Recommended name:
    Partitioning defective 6 homolog gamma
    Protein Accession:
    Q9BYG4
    Secondary Accessions:
    • A8QM57

    Protein attributes for PARD6G Gene

    Size:
    376 amino acids
    Molecular mass:
    40883 Da
    Quaternary structure:
    • Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ.

    Alternative splice isoforms for PARD6G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARD6G Gene

Proteomics data for PARD6G Gene at MOPED

Post-translational modifications for PARD6G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARD6G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PARD6G Gene

Domains & Families for PARD6G Gene

Gene Families for PARD6G Gene

Protein Domains for PARD6G Gene

Suggested Antigen Peptide Sequences for PARD6G Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYG4

UniProtKB/Swiss-Prot:

PAR6G_HUMAN :
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Belongs to the PAR6 family.
Domain:
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Contains 1 PB1 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 pseudo-CRIB domain.
Family:
  • Belongs to the PAR6 family.
genes like me logo Genes that share domains with PARD6G: view

Function for PARD6G Gene

Molecular function for PARD6G Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).

Phenotypes for PARD6G Gene

genes like me logo Genes that share phenotypes with PARD6G: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARD6G Gene

Localization for PARD6G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD6G Gene

Cytoplasm. Cell membrane. Cell junction, tight junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARD6G Gene COMPARTMENTS Subcellular localization image for PARD6G gene
Compartment Confidence
cytosol 5
plasma membrane 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PARD6G: view

Pathways & Interactions for PARD6G Gene

genes like me logo Genes that share pathways with PARD6G: view

Gene Ontology (GO) - Biological Process for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with PARD6G: view

No data available for SIGNOR curated interactions for PARD6G Gene

Drugs & Compounds for PARD6G Gene

(1) Drugs for PARD6G Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PARD6G: view

Transcripts for PARD6G Gene

mRNA/cDNA for PARD6G Gene

Unigene Clusters for PARD6G Gene

Par-6 partitioning defective 6 homolog gamma (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARD6G Gene

No ASD Table

Relevant External Links for PARD6G Gene

GeneLoc Exon Structure for
PARD6G
ECgene alternative splicing isoforms for
PARD6G

Expression for PARD6G Gene

mRNA expression in normal human tissues for PARD6G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARD6G Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.2) and Skin - Not Sun Exposed (Suprapubic) (x5.7).

Protein differential expression in normal tissues from HIPED for PARD6G Gene

This gene is overexpressed in Adipocyte (39.4) and Heart (29.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARD6G Gene



SOURCE GeneReport for Unigene cluster for PARD6G Gene Hs.654920

mRNA Expression by UniProt/SwissProt for PARD6G Gene

Q9BYG4-PAR6G_HUMAN
Tissue specificity: Widely expressed, with a higher expression in fetal and adult kidney.
genes like me logo Genes that share expression patterns with PARD6G: view

Protein tissue co-expression partners for PARD6G Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PARD6G Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD6G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARD6G 35
  • 82.57 (n)
  • 83.29 (a)
PARD6G 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARD6G 35
  • 80.7 (n)
  • 78.67 (a)
PARD6G 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pard6g 35
  • 77.9 (n)
  • 78.88 (a)
Pard6g 16
Pard6g 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pard6g 35
  • 79.41 (n)
  • 79.95 (a)
chimpanzee
(Pan troglodytes)
Mammalia PARD6G 36
  • 100 (a)
OneToOne
PARD6G 35
  • 99.65 (n)
  • 99.73 (a)
oppossum
(Monodelphis domestica)
Mammalia PARD6G 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARD6G 35
  • 68.66 (n)
  • 72.16 (a)
PARD6G 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARD6G 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pard6g 35
  • 64.27 (n)
  • 69.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1701 35
zebrafish
(Danio rerio)
Actinopterygii Dr.27686 35
pard6gb 35
  • 66.49 (n)
  • 67.73 (a)
pard6ga 36
  • 42 (a)
OneToMany
pard6gb 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta par-6 37
  • 53 (a)
par-6 35
  • 60.22 (n)
  • 62.18 (a)
par-6 36
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010494 35
  • 60.92 (n)
  • 62.61 (a)
worm
(Caenorhabditis elegans)
Secernentea par-6 37
  • 55 (a)
par-6 35
  • 53.65 (n)
  • 58.96 (a)
par-6 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7159 36
  • 40 (a)
OneToMany
Species with no ortholog for PARD6G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARD6G Gene

ENSEMBL:
Gene Tree for PARD6G (if available)
TreeFam:
Gene Tree for PARD6G (if available)

Paralogs for PARD6G Gene

Paralogs for PARD6G Gene

(3) SIMAP similar genes for PARD6G Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARD6G: view

Variants for PARD6G Gene

Sequence variations from dbSNP and Humsavar for PARD6G Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1105580 -- 80,241,462(+) caatg(C/T)attta intron-variant
rs1533654 -- 80,224,345(-) ACTTT(C/T)ATACC intron-variant
rs1122752 -- 80,240,492(-) AGCAT(C/T)GGAGG intron-variant
rs1122753 -- 80,240,457(-) ATTAG(G/T)GACAT intron-variant
rs1122754 -- 80,240,452(-) GGACA(C/T)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARD6G Gene

Variant ID Type Subtype PubMed ID
nsv428359 CNV Gain 18775914
nsv910009 CNV Loss 21882294
dgv3495n71 CNV Gain 21882294
nsv458317 CNV Gain 19166990
nsv910068 CNV Gain 21882294
nsv910069 CNV Loss 21882294
esv2661105 CNV Deletion 23128226
esv2676946 CNV Deletion 23128226
esv2663498 CNV Deletion 23128226
nsv507886 CNV Insertion 20534489
esv2678187 CNV Deletion 23128226

Variation tolerance for PARD6G Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARD6G Gene

HapMap Linkage Disequilibrium report
PARD6G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARD6G Gene

Disorders for PARD6G Gene

Relevant External Links for PARD6G

Genetic Association Database (GAD)
PARD6G
Human Genome Epidemiology (HuGE) Navigator
PARD6G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARD6G

No disorders were found for PARD6G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARD6G Gene

Publications for PARD6G Gene

  1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PMID: 11260256) Noda Y. … Sumimoto H. (Genes Cells 2001) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Par6I^ is at the mother centriole and controls centrosomal protein composition through a Par6I+-dependent pathway. (PMID: 23264737) Dormoy V. … SA1tterlin C. (J. Cell. Sci. 2013) 3
  4. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  5. The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells. (PMID: 23439680) Hayase J. … Sumimoto H. (J. Cell Biol. 2013) 3

Products for PARD6G Gene

Sources for PARD6G Gene

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