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PARD6G Gene

protein-coding   GIFtS: 54
GCID: GC18M077915

Par-6 Family Cell Polarity Regulator Gamma

(Previous names: par-6 (partitioning defective 6, C.elegans) homolog gamma,...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Par-6 Family Cell Polarity Regulator Gamma1 2     PAR-6 Gamma Protein2
PAR6D2 3     Par-6 Partitioning Defective 6 Homolog Gamma2
Par-6 (Partitioning Defective 6, C.Elegans) Homolog Gamma1     Partitioning Defective 6 Homolog Gamma2
Par-6 Partitioning Defective 6 Homolog Gamma (C. Elegans)1     PAR6G3
PAR-6G2     PAR-6 Gamma3
PAR6gamma2     

External Ids:    HGNC: 160761   Entrez Gene: 845522   Ensembl: ENSG000001781847   OMIM: 6089765   UniProtKB: Q9BYG43   

Export aliases for PARD6G gene to outside databases

Previous GC identifers: GC18M077432 GC18M077971 GC18M077652 GC18M076016 GC18M076014 GC18M075999 GC18M074536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PARD6G Gene:
PARD6G (par-6 family cell polarity regulator gamma) is a protein-coding gene. Diseases associated with PARD6G include malaria. An important paralog of this gene is PARD6B.

UniProtKB/Swiss-Prot: PAR6G_HUMAN, Q9BYG4
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role
in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to
atypical protein kinase C proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARD6G gene promoter:
         p53   Brachyury   AP-2gamma   POU3F2   Nkx5-1   E47   CREB   AP-2beta   Hand1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARD6G promoter sequence
   Search Chromatin IP Primers for PARD6G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARD6G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

PARD6G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARD6G gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M077915:  view genomic region     (about GC identifiers)

Start:
77,915,115 bp from pter      End:
78,005,429 bp from pter
Size:
90,315 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAR6G_HUMAN, Q9BYG4 (See protein sequence)
Recommended Name: Partitioning defective 6 homolog gamma  
Size: 376 amino acids; 40883 Da
Subunit: Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts
with the N-terminal part of PRKCI and PRKCZ
Secondary accessions: A8QM57
Alternative splicing: 2 isoforms:  Q9BYG4-1   Q9BYG4-2   

Explore the universe of human proteins at neXtProt for PARD6G: NX_Q9BYG4

Explore proteomics data for PARD6G at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PARD6G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115899.1  
    ENSEMBL proteins: 
     ENSP00000343144   ENSP00000468735   ENSP00000466076  
    Reactome Protein details: Q9BYG4

    PARD6G Human Recombinant Protein Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000270 OPR_PB1
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9BYG4

    ProtoNet protein and cluster: Q9BYG4

    2 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: PAR6G_HUMAN, Q9BYG4
    Domain: The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases
    (By similarity)
    Similarity: Belongs to the PAR6 family
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 pseudo-CRIB domain


    PARD6G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR6G_HUMAN, Q9BYG4
    Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role
    in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to
    atypical protein kinase C proteins (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11260256
         
    PARD6G for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARD6G
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARD6G
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARD6G

    miRNA
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    Block miRNA regulation of human, mouse, rat PARD6G using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARD6G (see all 20):
    hsa-miR-320a hsa-miR-148b* hsa-miR-3942-5p hsa-miR-410 hsa-miR-133a hsa-miR-761 hsa-miR-3163 hsa-miR-634
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PARD6G

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PARD6G (NM_032510)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARD6G

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARD6G


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAR6G_HUMAN, Q9BYG4: Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IEA--
    GO:0043234protein complex IEA--

    PARD6G for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARD6G About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    3Development A2A receptor signaling
    Development A2A receptor signaling0.43
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    5Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for PARD6G
        Development A2A receptor signaling
    G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes

    1 Reactome Pathway for PARD6G
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for PARD6G):
        Rap1 signaling pathway
    Endocytosis
    Hippo signaling pathway
    Tight junction


    PARD6G for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PARD6G
    Interactions:

        Search GeneGlobe Interaction Network for PARD6G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARD6G (Q9BYG41, 2, 3 ENSP000003431444) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCZQ055131, 2, 3, ENSP000003678304EBI-295417,EBI-295351 MINT-4085549 I2D: score=4 STRING: ENSP00000367830
    PARD3Q8TEW01, 3, ENSP000003639214EBI-295417,EBI-81968 I2D: score=4 STRING: ENSP00000363921
    MARK4Q96L341, 3, ENSP000003008434EBI-295417,EBI-302319 I2D: score=1 STRING: ENSP00000300843
    CDH5P331512, 3, ENSP000003441154MINT-4085562 I2D: score=1 STRING: ENSP00000344115
    CDC42P609531, 3, ENSP000003144584EBI-295417,EBI-81752 I2D: score=6 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0051301cell division IEA--
    GO:0070830tight junction assembly TAS--

    PARD6G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PARD6G (PAR6G)

    1 HMDB Compound for PARD6G    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PARD6G gene: 
    NM_032510.3  

    Unigene Cluster for PARD6G:

    Par-6 partitioning defective 6 homolog gamma (C. elegans)
    Hs.654920  [show with all ESTs]
    Unigene Representative Sequence: NM_032510
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353265(uc002lny.3 uc010xfp.2) ENST00000470488 ENST00000463384

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PARD6G (see all 20):
    hsa-miR-320a hsa-miR-148b* hsa-miR-3942-5p hsa-miR-410 hsa-miR-133a hsa-miR-761 hsa-miR-3163 hsa-miR-634
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PARD6G
      QuantiFast Probe-based Assays in human, mouse, rat PARD6G

    Additional mRNA sequence: 

    AB043635.2 AB044556.1 AB178535.1 AB178536.1 AK128802.1 BC060797.1 

    6 DOTS entries:

    DT.101981386  DT.95306194  DT.314905  DT.430579  DT.121103987  DT.91884658 

    Selected AceView cDNA sequences (see all 65):

    AI572539 BF223304 CD673647 F09758 AB044556 AI468587 BE674937 AI089398 
    AA262306 AW298290 BF197266 CD673646 AW028673 BU166212 AI492533 AI378759 
    T30545 AI174619 AB043635 BU679415 BF508997 AW872849 AA782677 AI056183 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARD6G expression in normal human tissues (normalized intensities)      PARD6G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGTTCAGTG
    PARD6G Expression
    About this image


    PARD6G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Rib
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Stomach (Gastrointestinal Tract)
    PARD6G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARD6G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654920

    UniProtKB/Swiss-Prot: PAR6G_HUMAN, Q9BYG4
    Tissue specificity: Widely expressed, with a higher expression in fetal and adult kidney

        Custom PCR Arrays for PARD6G
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARD6G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PARD6G gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pard6g1 , 5 par-6 partitioning defective 6 homolog gamma (C. elegans)5
    par-6 family cell polarity regulator gamma1
    77.9(n)1
    78.88(a)1
      18 (53.22 cM)5
    937371  NM_053117.31  NP_444347.31 
     800468955 
    chicken
    (Gallus gallus)
    Aves PARD6G1 par-6 partitioning defective 6 homolog gamma (C. elegans) 68.66(n)
    72.16(a)
      428511  XM_426065.4  XP_426065.4 
    lizard
    (Anolis carolinensis)
    Reptilia PARD6G6
    par-6 family cell polarity regulator gamma
    64(a)
    1 ↔ 1
    4(53266469-53343515)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.17012 Xenopus laevis transcribed sequence with moderate similarity more 73.99(n)    BX854029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.276862 Danio rerio par-6 partitioning defective 6-like protein more 76.61(n)    BC059186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta par-61 , 3 border cell migration3
    par-61
    53(a)3
    60.22(n)1
    62.18(a)1
      16C13
    327521  NM_133010.41  NP_573238.11 
    worm
    (Caenorhabditis elegans)
    Secernentea par-61 , 3 PDZ domain (Also known as DHR or GLGF).3
    par-61
    55(a)3
    53.65(n)1
    58.96(a)1
      I(12677659-12679516)3
    1731371  NM_001047222.41  NP_001040687.11 


    ENSEMBL Gene Tree for PARD6G (if available)
    TreeFam Gene Tree for PARD6G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARD6G gene
    PARD6B2  PARD6A2  
    3 SIMAP similar genes for PARD6G using alignment to 4 protein entries:     PAR6G_HUMAN (see all proteins):
    16-5-5    PARD6B    PARD6A

    PARD6G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARD6G (see all 892)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386769301,2
    --77845638(+) CTTTGG/TATTTG 1 -- us2k10--------
    rs106228391,2
    C--77923444(+) gagat-/TAAAG 
            
    taaag
    1 -- int10--------
    rs713380921,2
    C,F--77926795(+) TTCTTACAAA   
      TAAC
    /-
    ACAAA
    1 -- cds12Minor allele frequency- -:0.50NA CSA 4
    rs560883851,2
    C,F--77936870(+) GGACAC/TGCCAG 1 -- int12Minor allele frequency- T:0.04WA 120
    rs116612131,2
    C,F,A,H--77936877(+) CCAGAG/ACCCAG 1 -- int15Minor allele frequency- A:0.18NA WA 244
    rs116614121,2
    C,F,A,H--77936878(+) CAGAGC/ACCAGG 1 -- int15Minor allele frequency- A:0.17NA WA 244
    rs1160839871,2
    C,F--77936931(+) TTTTCC/AGAGGC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1124971661,2
    C,F--77936940(+) GCCACG/AAAGAG 1 -- int12Minor allele frequency- A:0.02CSA WA 120
    rs734924801,2
    C--77937060(+) GGTGTG/AGCCCA 1 -- int12Minor allele frequency- A:0.17WA 120
    rs346500221,2
    C--77937107(+) TTTTT-/T/T   
       T
    /TTT
    CAAAC
    2 -- int1 cds11NA 2

    HapMap Linkage Disequilibrium report for PARD6G (77915115 - 78005429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PARD6G (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676946CNV Deletion23128226
    esv2663498CNV Deletion23128226
    esv2661105CNV Deletion23128226
    esv2678187CNV Deletion23128226
    nsv507886CNV Insertion20534489
    nsv910069CNV Loss21882294
    nsv910009CNV Loss21882294
    dgv3495n71CNV Gain21882294
    nsv458317CNV Gain19166990
    nsv428359CNV Gain18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608976    OMIM disorders: --

    1 disease for PARD6G:    About MalaCards
    malaria


    PARD6G for disorders           About GeneDecksing

    Genetic Association Database (GAD): PARD6G
    Human Genome Epidemiology (HuGE) Navigator: PARD6G (1 document)

    Export disorders for PARD6G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PARD6G gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with PARD6G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PubMed id 11260256)1, 2, 3 Noda Y.... Sumimoto H. (Genes Cells 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PubMed id 10934474)1, 2 Joberty G.... Macara I.G. (Nat. Cell Biol. 2000)
    5. Par6I^ is at the mother centriole and controls centrosomal protein composition through a Par6I+-dependent pathway. (PubMed id 23264737)1 Dormoy V....SA1tterlin C. (J. Cell. Sci. 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)1 Brajenovic M.... Drewes G. (J. Biol. Chem. 2004)
    10. PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. (PubMed id 12459187)1 Kohjima M.... Sumimoto H. (Biochem. Biophys. Res. Commun. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84552 HGNC: 16076 AceView: PARD6G Ensembl:ENSG00000178184 euGenes: HUgn84552
    ECgene: PARD6G Kegg: 84552 H-InvDB: PARD6G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PARD6G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PARD6G gene:
    Search GeneIP for patents involving PARD6G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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