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Aliases for PARD6G Gene

Aliases for PARD6G Gene

  • Par-6 Family Cell Polarity Regulator Gamma 2 3
  • PAR6D 3 4
  • Par-6 (Partitioning Defective 6, C.Elegans) Homolog Gamma 2
  • Par-6 Partitioning Defective 6 Homolog Gamma (C. Elegans) 2
  • Par-6 Partitioning Defective 6 Homolog Gamma 3
  • Partitioning Defective 6 Homolog Gamma 3
  • PAR-6 Gamma Protein 3
  • PAR-6 Gamma 4
  • PAR6gamma 3
  • PAR-6G 3
  • PAR6G 4

External Ids for PARD6G Gene

Previous GeneCards Identifiers for PARD6G Gene

  • GC18M077432
  • GC18M077971
  • GC18M077652
  • GC18M076016
  • GC18M076014
  • GC18M075999
  • GC18M077915
  • GC18M074536

Summaries for PARD6G Gene

GeneCards Summary for PARD6G Gene

PARD6G (Par-6 Family Cell Polarity Regulator Gamma) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Endocytosis. An important paralog of this gene is PARD6A.

UniProtKB/Swiss-Prot for PARD6G Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD6G Gene

Genomics for PARD6G Gene

Regulatory Elements for PARD6G Gene

Genomic Location for PARD6G Gene

Start:
80,157,232 bp from pter
End:
80,247,546 bp from pter
Size:
90,315 bases
Orientation:
Minus strand

Genomic View for PARD6G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARD6G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD6G Gene

Proteins for PARD6G Gene

  • Protein details for PARD6G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG4-PAR6G_HUMAN
    Recommended name:
    Partitioning defective 6 homolog gamma
    Protein Accession:
    Q9BYG4
    Secondary Accessions:
    • A8QM57

    Protein attributes for PARD6G Gene

    Size:
    376 amino acids
    Molecular mass:
    40883 Da
    Quaternary structure:
    • Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ.

    Alternative splice isoforms for PARD6G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARD6G Gene

Proteomics data for PARD6G Gene at MOPED

Post-translational modifications for PARD6G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARD6G Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PARD6G Gene

Domains for PARD6G Gene

Protein Domains for PARD6G Gene

Suggested Antigen Peptide Sequences for PARD6G Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYG4

UniProtKB/Swiss-Prot:

PAR6G_HUMAN :
  • Q9BYG4
Domain:
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Contains 1 PB1 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 pseudo-CRIB domain.
Family:
  • Belongs to the PAR6 family.
genes like me logo Genes that share domains with PARD6G: view

No data available for Gene Families for PARD6G Gene

Function for PARD6G Gene

Molecular function for PARD6G Gene

UniProtKB/Swiss-Prot Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).

Gene Ontology (GO) - Molecular Function for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11260256
genes like me logo Genes that share ontologies with PARD6G: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PARD6G Gene

Localization for PARD6G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD6G Gene

Cytoplasm. Cell membrane. Cell junction, tight junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARD6G Gene COMPARTMENTS Subcellular localization image for PARD6G gene
Compartment Confidence
cytosol 4
plasma membrane 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with PARD6G: view

Pathways for PARD6G Gene

genes like me logo Genes that share pathways with PARD6G: view

Gene Ontology (GO) - Biological Process for PARD6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0034329 cell junction assembly TAS --
GO:0045216 cell-cell junction organization TAS --
GO:0051301 cell division IEA --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with PARD6G: view

Compounds for PARD6G Gene

(1) HMDB Compounds for PARD6G Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with PARD6G: view

Transcripts for PARD6G Gene

mRNA/cDNA for PARD6G Gene

Unigene Clusters for PARD6G Gene

Par-6 partitioning defective 6 homolog gamma (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARD6G Gene

No ASD Table

Relevant External Links for PARD6G Gene

GeneLoc Exon Structure for
PARD6G
ECgene alternative splicing isoforms for
PARD6G

Expression for PARD6G Gene

mRNA expression in normal human tissues for PARD6G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARD6G Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (6.2) and Skin - Not Sun Exposed (Suprapubic) (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PARD6G Gene

SOURCE GeneReport for Unigene cluster for PARD6G Gene Hs.654920

mRNA Expression by UniProt/SwissProt for PARD6G Gene

Q9BYG4-PAR6G_HUMAN
Tissue specificity: Widely expressed, with a higher expression in fetal and adult kidney
genes like me logo Genes that share expressions with PARD6G: view

Orthologs for PARD6G Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD6G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARD6G 35
  • 99.65 (n)
  • 99.73 (a)
PARD6G 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARD6G 35
  • 82.57 (n)
  • 83.29 (a)
PARD6G 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARD6G 35
  • 80.7 (n)
  • 78.67 (a)
PARD6G 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pard6g 35
  • 77.9 (n)
  • 78.88 (a)
Pard6g 16
Pard6g 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARD6G 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pard6g 35
  • 79.41 (n)
  • 79.95 (a)
chicken
(Gallus gallus)
Aves PARD6G 35
  • 68.66 (n)
  • 72.16 (a)
PARD6G 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARD6G 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1701 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pard6g 35
  • 64.27 (n)
  • 69.33 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27686 35
pard6ga 36
  • 42 (a)
OneToMany
pard6gb 35
  • 66.49 (n)
  • 67.73 (a)
pard6gb 36
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010494 35
  • 60.92 (n)
  • 62.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta par-6 35
  • 60.22 (n)
  • 62.18 (a)
par-6 36
  • 47 (a)
OneToMany
par-6 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea par-6 35
  • 53.65 (n)
  • 58.96 (a)
par-6 36
  • 49 (a)
OneToMany
par-6 37
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7159 36
  • 40 (a)
OneToMany
Species with no ortholog for PARD6G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARD6G Gene

ENSEMBL:
Gene Tree for PARD6G (if available)
TreeFam:
Gene Tree for PARD6G (if available)

Paralogs for PARD6G Gene

Paralogs for PARD6G Gene

Selected SIMAP similar genes for PARD6G Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PARD6G: view

Variants for PARD6G Gene

Sequence variations from dbSNP and Humsavar for PARD6G Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs884779 -- 80,181,018(-) CAGCC(C/T)GCTGG intron-variant
rs1105580 -- 80,241,462(+) caatg(C/T)attta intron-variant
rs1122752 -- 80,240,492(-) AGCAT(C/T)GGAGG intron-variant
rs1122753 -- 80,240,457(-) ATTAG(G/T)GACAT intron-variant
rs1122754 -- 80,240,452(-) GGACA(C/T)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARD6G Gene

Variant ID Type Subtype PubMed ID
nsv428359 CNV Gain 18775914
nsv910009 CNV Loss 21882294
dgv3495n71 CNV Gain 21882294
nsv458317 CNV Gain 19166990
nsv910068 CNV Gain 21882294
nsv910069 CNV Loss 21882294
esv2661105 CNV Deletion 23128226
esv2676946 CNV Deletion 23128226
esv2663498 CNV Deletion 23128226
nsv507886 CNV Insertion 20534489
esv2678187 CNV Deletion 23128226

Relevant External Links for PARD6G Gene

HapMap Linkage Disequilibrium report
PARD6G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARD6G Gene

Disorders for PARD6G Gene

Relevant External Links for PARD6G

Genetic Association Database (GAD)
PARD6G
Human Genome Epidemiology (HuGE) Navigator
PARD6G
genes like me logo Genes that share disorders with PARD6G: view

No data available for UniProtKB/Swiss-Prot for PARD6G Gene

Publications for PARD6G Gene

  1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PMID: 11260256) Noda Y. … Sumimoto H. (Genes Cells 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PMID: 10934474) Joberty G. … Macara I.G. (Nat. Cell Biol. 2000) 3 4
  5. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. (PMID: 11257119) Suzuki A. … Ohno S. (J. Cell Biol. 2001) 3

Products for PARD6G Gene

Sources for PARD6G Gene

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