Aliases for PARD6B Gene
External Ids for PARD6B Gene
Previous GeneCards Identifiers for PARD6B Gene
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARD6B Gene
PARD6B (Par-6 Family Cell Polarity Regulator Beta) is a Protein Coding gene. Diseases associated with PARD6B include Microvillus Inclusion Disease. Among its related pathways are Development A2B receptor- action via G-protein alpha s and Tight junction. An important paralog of this gene is PARD6G.
UniProtKB/Swiss-Prot for PARD6B Gene
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.