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PARD6B Gene

protein-coding   GIFtS: 60
GCID: GC20P049348

Par-6 Family Cell Polarity Regulator Beta

(Previous names: par-6 (partitioning defective 6, C.elegans) homolog beta,...)
  Search for PARD6B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Par-6 Family Cell Polarity Regulator Beta1 2     Par-6 Partitioning Defective 6 Homolog Beta (C. Elegans)1
PAR6B2 3     Par-6 Partitioning Defective 6 Homolog Beta2
PAR-6 Beta2 3     Partitioning Defective 6 Homolog Beta2
Par-6 (Partitioning Defective 6, C.Elegans) Homolog Beta1     PAR-6B3

External Ids:    HGNC: 162451   Entrez Gene: 846122   Ensembl: ENSG000001241717   OMIM: 6089755   UniProtKB: Q9BYG53   

Export aliases for PARD6B gene to outside databases

Previous GC identifers: GC20P049076 GC20P049986 GC20P050033 GC20P048781 GC20P046096


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PARD6B Gene:
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR
domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in
asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PARD6B Gene:
PARD6B (par-6 family cell polarity regulator beta) is a protein-coding gene. An important paralog of this gene is PARD6G.

UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably
involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3
with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small
GTPases to atypical protein kinase C proteins

Gene Wiki entry for PARD6B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARD6B gene promoter:
         Pax-5   CBF-C   Egr-4   Arnt   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARD6B promoter sequence
   Search Chromatin IP Primers for PARD6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARD6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

PARD6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARD6B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P049348:  view genomic region     (about GC identifiers)

Start:
49,348,081 bp from pter      End:
49,373,332 bp from pter
Size:
25,252 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5 (See protein sequence)
Recommended Name: Partitioning defective 6 homolog beta  
Size: 372 amino acids; 41182 Da
Subunit: Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound
ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a
complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with
ALS2CR19. Interacts with ECT2
Secondary accessions: A2A2A7 Q9Y510
Alternative splicing: 2 isoforms:  Q9BYG5-1   Q9BYG5-2   

Explore the universe of human proteins at neXtProt for PARD6B: NX_Q9BYG5

Explore proteomics data for PARD6B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PARD6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115910.1  
    ENSEMBL proteins: 
     ENSP00000360672   ENSP00000379354  
    Reactome Protein details: Q9BYG5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000270 OPR_PB1
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9BYG5

    ProtoNet protein and cluster: Q9BYG5

    2 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5
    Domain: The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases
    Domain: The PDZ domain mediates interaction with MPP5 (By similarity)
    Similarity: Belongs to the PAR6 family
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 pseudo-CRIB domain


    Find genes that share domains with PARD6B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR6B_HUMAN, Q9BYG5
    Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably
    involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3
    with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small
    GTPases to atypical protein kinase C proteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11260256
         
    Find genes that share ontologies with PARD6B           About GenesLikeMe


    Animal Models:
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    Block miRNA regulation of human, mouse, rat PARD6B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARD6B (see all 108):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-100* hsa-miR-376b hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-1245
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    eBioscience FlowRNA Probe Sets ( VA1-11980) for PARD6B 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAR6B_HUMAN, Q9BYG5: Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    mitochondrion2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IDA12545177

    Find genes that share ontologies with PARD6B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARD6B About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    3Development A2A receptor signaling
    Development A2A receptor signaling0.43
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with PARD6B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for PARD6B
        Development A2A receptor signaling
    G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes


    1 Reactome Pathway for PARD6B
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for PARD6B):
        Rap1 signaling pathway
    Endocytosis
    Hippo signaling pathway
    Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Array including PARD6B: 
              Tight Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PARD6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARD6B (Q9BYG51, 3 ENSP000003606724) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCZQ055131, 3, ENSP000003678304EBI-295391,EBI-295351 I2D: score=4 STRING: ENSP00000367830
    PARD3Q8TEW01, 3, ENSP000003639214EBI-295391,EBI-81968 I2D: score=3 STRING: ENSP00000363921
    CDC42P609531, 3, ENSP000003144584EBI-295391,EBI-81752 I2D: score=8 STRING: ENSP00000314458
    PRKCIP417431, 3, ENSP000002957974EBI-295391,EBI-286199 I2D: score=4 STRING: ENSP00000295797
    RAC1P630001, 3, ENSP000003484614EBI-295391,EBI-413628 I2D: score=8 STRING: ENSP00000348461
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    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly IDA12545177
    GO:0007043cell-cell junction assembly TAS12545177
    GO:0007049cell cycle IEA--
    GO:0007163establishment or maintenance of cell polarity TAS14676191
    GO:0007409axonogenesis TAS14676191

    Find genes that share ontologies with PARD6B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PARD6B (PAR6B)

    1 HMDB Compound for PARD6B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PARD6B gene: 
    NM_032521.2  

    Unigene Cluster for PARD6B:

    Par-6 partitioning defective 6 homolog beta (C. elegans)
    Hs.589848  [show with all ESTs]
    Unigene Representative Sequence: NM_032521
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371610(uc002xvo.3) ENST00000396039
    miRNA
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    hsa-miR-579 hsa-miR-140-5p hsa-miR-100* hsa-miR-376b hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-1245
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    Additional mRNA sequence: 

    AB044555.1 AB178534.1 BC060847.1 

    2 DOTS entries:

    DT.445226  DT.91924327 

    Selected AceView cDNA sequences (see all 47):

    AA136921 AI690127 CA435324 BI087682 AB044555 AI955040 BM955994 CB850649 
    CA313486 H86080 BX282328 BU680154 BI439179 BX091024 N69468 BM825947 
    AW151704 BG249649 AA054643 AA682861 AW369746 AI056752 BF434158 CB959958 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARD6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGATACTT
    PARD6B Expression
    About this image


    PARD6B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    PARD6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARD6B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.589848

    UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5
    Tissue specificity: Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and
    lung. Not expressed in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including PARD6B: 
              Tight Junctions in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARD6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PARD6B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pard6b1 , 5 par-6 (partitioning defective 6) homolog beta (C. elegans)5
    par-6 family cell polarity regulator beta1
    80.32(n)1
    91.64(a)1
      2 (88.24 cM)5
    582201  NM_021409.21  NP_067384.21 
     1680810045 
    chicken
    (Gallus gallus)
    Aves PARD6B1 par-6 partitioning defective 6 homolog beta (C. elegans) 77.57(n)
    83.78(a)
      419352  NM_001044641.2  NP_001038106.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARD6B6
    par-6 family cell polarity regulator beta
    84(a)
    1 ↔ 1
    GL343226.1(2170581-2196746)
    African clawed frog
    (Xenopus laevis)
    Amphibia Par-62 Par-6 protein 75.53(n)    AF152346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pard6b1 par-6 partitioning defective 6 homolog beta (C. elegans) 63.8(n)
    69.83(a)
      100124652  NM_001102675.1  NP_001096145.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta par-63 border cell migration 56(a)   16C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea par-63 PDZ domain (Also known as DHR or GLGF). 54(a)   I(12677659-12679516)   --


    ENSEMBL Gene Tree for PARD6B (if available)
    TreeFam Gene Tree for PARD6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARD6B gene
    PARD6G2  PARD6A2  
    3 SIMAP similar genes for PARD6B using alignment to 1 protein entry:     PAR6B_HUMAN:
    16-5-5    PARD6G    PARD6A

    Find genes that share paralogs with PARD6B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PARD6B
    PGOHUM00000241527


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARD6B (see all 584)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60960711,2
    C,F--49346177(+) caaagT/Cacttt 1 -- us2k1 tfbs36Minor allele frequency- C:0.17NA WA CSA 246
    rs1466225641,2
    --49346481(+) TTCTCA/GCCTTT 1 -- us2k10--------
    rs1875711941,2
    --49346564(+) TACCCA/GCTGGG 1 -- us2k10--------
    rs1933005891,2
    --49346745(+) GCCTCC/TGAGGT 1 -- us2k10--------
    rs1413616411,2
    --49346747(+) CTCCGA/GGGTGG 1 -- us2k10--------
    rs2315831,2
    C,F,O,A,H--49346881(-) GGACCT/CGGGAA 1 -- us2k125Minor allele frequency- C:0.27NS EA NA WA CSA 2485
    rs1837815951,2
    --49346906(+) GGGACA/CTGGGA 1 -- us2k10--------
    rs1439785341,2
    C--49346940(+) GTCTT-/CTCCCTCT 1 -- us2k10--------
    rs1450923251,2
    --49346969(+) GGGTCC/TGTGTG 1 -- us2k10--------
    rs114817711,2
    C--49347141(+) AAAAAA/-GCCCT 1 -- us2k1 trp32Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for PARD6B (49348081 - 49373332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PARD6B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834001CNV Loss17160897
    nsv523874CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608975    OMIM disorders: --


    Find genes that share disorders with PARD6B           About GenesLikeMe

    Genetic Association Database (GAD): PARD6B

    Export disorders for PARD6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PARD6B gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PARD6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PubMed id 11260256)1, 2, 3 Noda Y.... Sumimoto H. (Genes Cells 2001)
    2. Genome-wide association study on bipolar disorder in the Bulgarian population. (PubMed id 21771265)1, 4 Yosifova A....Nakamura Y. (Genes Brain Behav. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. (PubMed id 12725730)1, 2 Yamanaka T.... Ohno S. (Curr. Biol. 2003)
    5. Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. (PubMed id 12234671)1, 2 Gao L.... Joberty G. (Gene 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    8. Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. (PubMed id 23718855)1 Waaijers S....Boxem M. (J. Proteome Res. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84612 HGNC: 16245 AceView: PARD6B Ensembl:ENSG00000124171 euGenes: HUgn84612
    ECgene: PARD6B Kegg: 84612 H-InvDB: PARD6B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PARD6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PARD6B gene:
    Search GeneIP for patents involving PARD6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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