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Aliases for PARD6B Gene

Aliases for PARD6B Gene

  • Par-6 Family Cell Polarity Regulator Beta 2 3 5
  • PAR-6 Beta 3 4
  • PAR6B 3 4
  • Par-6 (Partitioning Defective 6, C.Elegans) Homolog Beta 2
  • Par-6 Partitioning Defective 6 Homolog Beta (C. Elegans) 2
  • Par-6 Partitioning Defective 6 Homolog Beta 3
  • PAR-6B 4

External Ids for PARD6B Gene

Previous GeneCards Identifiers for PARD6B Gene

  • GC20P049076
  • GC20P049986
  • GC20P050033
  • GC20P048781
  • GC20P049348
  • GC20P046096

Summaries for PARD6B Gene

Entrez Gene Summary for PARD6B Gene

  • This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARD6B Gene

PARD6B (Par-6 Family Cell Polarity Regulator Beta) is a Protein Coding gene. Among its related pathways are Cell junction organization and Axon guidance. An important paralog of this gene is PARD6G.

UniProtKB/Swiss-Prot for PARD6B Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Gene Wiki entry for PARD6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD6B Gene

Genomics for PARD6B Gene

Regulatory Elements for PARD6B Gene

Enhancers for PARD6B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PARD6B on UCSC Golden Path with GeneCards custom track

Promoters for PARD6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARD6B on UCSC Golden Path with GeneCards custom track

Genomic Location for PARD6B Gene

Chromosome:
20
Start:
50,731,544 bp from pter
End:
50,756,795 bp from pter
Size:
25,252 bases
Orientation:
Plus strand

Genomic View for PARD6B Gene

Genes around PARD6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARD6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARD6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD6B Gene

Proteins for PARD6B Gene

  • Protein details for PARD6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG5-PAR6B_HUMAN
    Recommended name:
    Partitioning defective 6 homolog beta
    Protein Accession:
    Q9BYG5
    Secondary Accessions:
    • A2A2A7
    • Q9Y510

    Protein attributes for PARD6B Gene

    Size:
    372 amino acids
    Molecular mass:
    41182 Da
    Quaternary structure:
    • Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2.

    Alternative splice isoforms for PARD6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARD6B Gene

Proteomics data for PARD6B Gene at MOPED

Post-translational modifications for PARD6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARD6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PARD6B Gene

Domains & Families for PARD6B Gene

Gene Families for PARD6B Gene

Protein Domains for PARD6B Gene

Suggested Antigen Peptide Sequences for PARD6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYG5

UniProtKB/Swiss-Prot:

PAR6B_HUMAN :
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Belongs to the PAR6 family.
Domain:
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • The PDZ domain mediates interaction with MPP5.
  • Contains 1 PB1 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 pseudo-CRIB domain.
Family:
  • Belongs to the PAR6 family.
genes like me logo Genes that share domains with PARD6B: view

Function for PARD6B Gene

Molecular function for PARD6B Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Phenotypes for PARD6B Gene

GenomeRNAi human phenotypes for PARD6B:
genes like me logo Genes that share phenotypes with PARD6B: view

Animal Model Products

miRNA for PARD6B Gene

miRTarBase miRNAs that target PARD6B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARD6B Gene

Localization for PARD6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD6B Gene

Cytoplasm. Cell membrane. Cell junction, tight junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARD6B Gene COMPARTMENTS Subcellular localization image for PARD6B gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
nucleus 3
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PARD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005923 bicellular tight junction IDA 12545177
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PARD6B: view

Pathways & Interactions for PARD6B Gene

genes like me logo Genes that share pathways with PARD6B: view

Gene Ontology (GO) - Biological Process for PARD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IDA 12545177
GO:0007043 cell-cell junction assembly TAS 12545177
GO:0007409 axonogenesis TAS 14676191
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with PARD6B: view

No data available for SIGNOR curated interactions for PARD6B Gene

Drugs & Compounds for PARD6B Gene

(1) Drugs for PARD6B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PARD6B: view

Transcripts for PARD6B Gene

mRNA/cDNA for PARD6B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PARD6B Gene

Par-6 partitioning defective 6 homolog beta (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARD6B Gene

No ASD Table

Relevant External Links for PARD6B Gene

GeneLoc Exon Structure for
PARD6B
ECgene alternative splicing isoforms for
PARD6B

Expression for PARD6B Gene

mRNA expression in normal human tissues for PARD6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARD6B Gene

This gene is overexpressed in Kidney - Cortex (x5.8).

Protein differential expression in normal tissues from HIPED for PARD6B Gene

This gene is overexpressed in Cervix (32.2) and Placenta (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARD6B Gene



SOURCE GeneReport for Unigene cluster for PARD6B Gene Hs.589848

mRNA Expression by UniProt/SwissProt for PARD6B Gene

Q9BYG5-PAR6B_HUMAN
Tissue specificity: Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
genes like me logo Genes that share expression patterns with PARD6B: view

Primer Products

No data available for Protein tissue co-expression partners for PARD6B Gene

Orthologs for PARD6B Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD6B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARD6B 35
  • 81.63 (n)
  • 89.78 (a)
PARD6B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pard6b 35
  • 80.32 (n)
  • 91.64 (a)
Pard6b 16
Pard6b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARD6B 35
  • 99.91 (n)
  • 100 (a)
PARD6B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pard6b 35
  • 79.12 (n)
  • 91.4 (a)
dog
(Canis familiaris)
Mammalia PARD6B 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PARD6B 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARD6B 35
  • 77.57 (n)
  • 83.78 (a)
PARD6B 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARD6B 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pard6b 35
  • 69.44 (n)
  • 76.88 (a)
Str.16596 35
African clawed frog
(Xenopus laevis)
Amphibia Par-6 35
zebrafish
(Danio rerio)
Actinopterygii pard6b 35
  • 63.8 (n)
  • 69.83 (a)
pard6b 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta par-6 37
  • 56 (a)
par-6 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea par-6 37
  • 54 (a)
par-6 36
  • 48 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11816 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7159 36
  • 40 (a)
OneToMany
Species with no ortholog for PARD6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARD6B Gene

ENSEMBL:
Gene Tree for PARD6B (if available)
TreeFam:
Gene Tree for PARD6B (if available)

Paralogs for PARD6B Gene

Paralogs for PARD6B Gene

(3) SIMAP similar genes for PARD6B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PARD6B Gene

genes like me logo Genes that share paralogs with PARD6B: view

Variants for PARD6B Gene

Sequence variations from dbSNP and Humsavar for PARD6B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs231582 -- 50,730,747(-) GGCTT(C/G)ATTTT upstream-variant-2KB
rs231583 -- 50,730,344(-) GGACC(C/T)GGGAA upstream-variant-2KB
rs1054185 -- 50,752,469(+) TTCCA(A/G)TGCAT utr-variant-3-prime
rs1136848 -- 50,744,144(+) AGTCT(C/T)GCTCT intron-variant
rs1136849 -- 50,744,244(+) cgagt(A/G)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARD6B Gene

Variant ID Type Subtype PubMed ID
nsv834001 CNV Loss 17160897
nsv523874 CNV Gain 19592680

Variation tolerance for PARD6B Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PARD6B Gene

Disorders for PARD6B Gene

Relevant External Links for PARD6B

Genetic Association Database (GAD)
PARD6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARD6B

No disorders were found for PARD6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARD6B Gene

Publications for PARD6B Gene

  1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PMID: 11260256) Noda Y. … Sumimoto H. (Genes Cells 2001) 2 3 4 67
  2. Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4. (PMID: 25662318) Jin D. … Hall A. (Biochem. J. 2015) 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PARD6B Gene

Sources for PARD6B Gene

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