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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PARD6B Gene

protein-coding   GIFtS: 60
GCID: GC20P049348

Par-6 Family Cell Polarity Regulator Beta

(Previous names: par-6 (partitioning defective 6, C.elegans) homolog beta,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Par-6 Family Cell Polarity Regulator Beta1 2     Par-6 Partitioning Defective 6 Homolog Beta (C. Elegans)1
PAR6B2 3     Par-6 Partitioning Defective 6 Homolog Beta2
PAR-6 Beta2 3     Partitioning Defective 6 Homolog Beta2
Par-6 (Partitioning Defective 6, C.Elegans) Homolog Beta1     PAR-6B3

External Ids:    HGNC: 162451   Entrez Gene: 846122   Ensembl: ENSG000001241717   OMIM: 6089755   UniProtKB: Q9BYG53   

Export aliases for PARD6B gene to outside databases

Previous GC identifers: GC20P049076 GC20P049986 GC20P050033 GC20P048781 GC20P046096


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PARD6B Gene:
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR
domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in
asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PARD6B Gene: 
PARD6B (par-6 family cell polarity regulator beta) is a protein-coding gene. Diseases associated with PARD6B include bipolar disorder, and breast cancer, and among its related super-pathways are Cell-cell junction organization and Cytoskeleton remodeling CDC42 in cellular processes. GO annotations related to this gene include protein binding. An important paralog of this gene is PARD6G.

UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably
involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3
with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small
GTPases to atypical protein kinase C proteins

Gene Wiki entry for PARD6B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PARD6B gene promoter:
         Pax-5   CBF-C   Egr-4   Arnt   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPARD6B promoter sequence
   Search SABiosciences Chromatin IP Primers for PARD6B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PARD6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

PARD6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARD6B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P049348:  view genomic region     (about GC identifiers)

Start:
49,348,081 bp from pter      End:
49,373,332 bp from pter
Size:
25,252 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5 (See protein sequence)
Recommended Name: Partitioning defective 6 homolog beta  
Size: 372 amino acids; 41182 Da
Subunit: Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound
ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a
complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with
ALS2CR19. Interacts with ECT2
Subcellular location: Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity)
Secondary accessions: Q9Y510

Explore the universe of human proteins at neXtProt for PARD6B: NX_Q9BYG5

Explore proteomics data for PARD6B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BYG5

  • PARD6B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PARD6B Protein Expression
    REFSEQ proteins: NP_115910.1  
    ENSEMBL proteins: 
     ENSP00000360672   ENSP00000379354  
    Reactome Protein details: Q9BYG5
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    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IDA12545177

    PARD6B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000270 OPR_PB1
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9BYG5

    ProtoNet protein and cluster: Q9BYG5

    2 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5
    Domain: The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases
    Domain: The PDZ domain mediates interaction with MPP5 (By similarity)
    Similarity: Belongs to the PAR6 family
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 pseudo-CRIB domain


    PARD6B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR6B_HUMAN, Q9BYG5
    Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably
    involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3
    with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small
    GTPases to atypical protein kinase C proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11260256
         
    PARD6B for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PARD6B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Cytoskeleton remodeling CDC42 in cellular processes
    G-protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    3Development A2B receptor- action via G-protein alpha s
    Development A2A receptor signaling0.43
    4Tight junction
    Tight junction
    5Hippo signaling pathway
    Hippo signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PARD6B
        G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes
    Development A2A receptor signaling


    3 GeneGo (Thomson Reuters) Pathways for PARD6B
        Development A2A receptor signaling
    G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes


    4        Reactome Pathways for PARD6B
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    3         Kegg Pathways  (Kegg details for PARD6B):
        Endocytosis
    Hippo signaling pathway
    Tight junction


    PARD6B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PARD6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/30 Interacting proteins for PARD6B (Q9BYG51, 3 ENSP000003606724) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCZQ055131, 3, ENSP000003678304EBI-295391,EBI-295351 I2D: score=4 STRING: ENSP00000367830
    PARD3Q8TEW01, 3, ENSP000003639214EBI-295391,EBI-81968 I2D: score=3 STRING: ENSP00000363921
    CDC42P609531, 3, ENSP000003144584EBI-295391,EBI-81752 I2D: score=8 STRING: ENSP00000314458
    PRKCIP417431, 3, ENSP000002957974EBI-295391,EBI-286199 I2D: score=4 STRING: ENSP00000295797
    RAC1P630001, 3, ENSP000003484614EBI-295391,EBI-413628 I2D: score=8 STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly IDA12545177
    GO:0007043cell-cell junction assembly TAS12545177
    GO:0007049cell cycle IEA--
    GO:0007163establishment or maintenance of cell polarity TAS14676191
    GO:0007409axonogenesis TAS14676191

    PARD6B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PARD6B (PAR6B)

    1 HMDB Compound for PARD6B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about PARD6B / PAR6B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PARD6B gene: 
    NM_032521.2  

    Unigene Cluster for PARD6B:

    Par-6 partitioning defective 6 homolog beta (C. elegans)
    Hs.589848  [show with all ESTs]
    Unigene Representative Sequence: NM_032521
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371610(uc002xvo.3) ENST00000396039
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    Additional mRNA sequence: 

    AB044555.1 AB178534.1 BC060847.1 

    2 DOTS entries:

    DT.445226  DT.91924327 

    24/47 AceView cDNA sequences (see all 47):

    AB044555 BI087682 H86080 CA435324 AI955040 AA136921 CB850649 CA313486 
    AI690127 BM955994 BX282328 AW151704 AA682861 BU680154 BM825947 AW369746 
    N69468 AA054643 BI439179 BX091024 AI056752 BG249649 AI950015 AA017338 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PARD6B expression in normal human tissues (normalized intensities)      PARD6B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGATACTT
    PARD6B Expression
    About this image


    PARD6B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Line H9 (WA09)
     
     Breast (Uncategorized)
             MAMMARY GLAND   

    See PARD6B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PARD6B

    SOURCE GeneReport for Unigene cluster: Hs.589848

    UniProtKB/Swiss-Prot: PAR6B_HUMAN, Q9BYG5
    Tissue specificity: Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and
    lung. Not expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including PARD6B: 
              Tight Junctions in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PARD6B gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pard6b1 , 5 par-6 (partitioning defective 6) homolog beta (C. elegans)1, 5 80.32(n)1
    91.64(a)1
      2 (88.24 cM)5
    582201  NM_021409.21  NP_067384.21 
     1680810045 
    chicken
    (Gallus gallus)
    Aves PARD6B1 par-6 partitioning defective 6 homolog beta (C. elegans) 77.57(n)
    83.78(a)
      419352  NM_001044641.1  NP_001038106.1 
    lizard
    (Anolis carolinensis)
    Reptilia PARD6B6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343226.1(2170581-2196746)
    African clawed frog
    (Xenopus laevis)
    Amphibia Par-62 Par-6 protein 75.53(n)    AF152346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pard6b1 par-6 partitioning defective 6 homolog beta (C. elegans) 63.8(n)
    69.83(a)
      100124652  NM_001102675.1  NP_001096145.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta par-63 border cell migration 56(a)   16C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea par-63 PDZ domain (Also known as DHR or GLGF). 54(a)   I(12677659-12679516)   --


    ENSEMBL Gene Tree for PARD6B (if available)
    TreeFam Gene Tree for PARD6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PARD6B gene
    PARD6G2  PARD6A2  
    3 SIMAP similar genes for PARD6B using alignment to 2 protein entries:     PAR6B_HUMAN (see all proteins):
    16-5-5    PARD6G    PARD6A

    PARD6B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PARD6B
    PGOHUM00000241527


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/584 SNPs in PARD6B are shown (see all 584)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60960711,2
    C,F--49346177(+) caaagT/Cacttt 1 -- us2k1 tfbs36Minor allele frequency- C:0.17NA WA CSA 246
    rs1466225641,2
    --49346481(+) TTCTCA/GCCTTT 1 -- us2k10--------
    rs1875711941,2
    --49346564(+) TACCCA/GCTGGG 1 -- us2k10--------
    rs1933005891,2
    --49346745(+) GCCTCC/TGAGGT 1 -- us2k10--------
    rs1413616411,2
    --49346747(+) CTCCGA/GGGTGG 1 -- us2k10--------
    rs2315831,2
    C,F,O,A,H--49346881(-) GGACCT/CGGGAA 1 -- us2k125Minor allele frequency- C:0.27NS EA NA WA CSA 2485
    rs1837815951,2
    --49346906(+) GGGACA/CTGGGA 1 -- us2k10--------
    rs1439785341,2
    C--49346940(+) GTCTT-/CTCCCTCT 1 -- us2k10--------
    rs1450923251,2
    --49346969(+) GGGTCC/TGTGTG 1 -- us2k10--------
    rs114817711,2
    C--49347141(+) AAAAAA/-GCCCT 1 -- us2k1 trp32Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for PARD6B (49348081 - 49373332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PARD6B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834001CNV Loss17160897
    nsv523874CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608975    OMIM disorders: --

    2 diseases for PARD6B:    About MalaCards
    bipolar disorder    breast cancer


    PARD6B for disorders           About GeneDecksing

    Genetic Association Database (GAD): PARD6B

    Export disorders for PARD6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PARD6B gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with PARD6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PubMed id 11260256)1, 2, 3 Noda Y.... Sumimoto H. (2001)
    2. Genome-wide association study on bipolar disorder in t he Bulgarian population. (PubMed id 21771265)1, 4 Yosifova A....Nakamura Y. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. (PubMed id 12725730)1, 2 Yamanaka T.... Ohno S. (2003)
    5. Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. (PubMed id 12234671)1, 2 Gao L.... Joberty G. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    8. Identification of human protein interaction domains us ing an ORFeome-based yeast two-hybrid fragment library. (PubMed id 23718855)1 Waaijers S....Boxem M. (2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Par6B and atypical PKC regulate mitotic spindle orien tation during epithelial morphogenesis. (PubMed id 21300793)1 Durgan J....Hall A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84612 HGNC: 16245 AceView: PARD6B Ensembl:ENSG00000124171 euGenes: HUgn84612
    ECgene: PARD6B Kegg: 84612 H-InvDB: PARD6B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PARD6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PARD6B gene:
    Search GeneIP for patents involving PARD6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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