Aliases for PARD6A Gene
External Ids for PARD6A Gene
Previous GeneCards Identifiers for PARD6A Gene
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARD6A Gene
PARD6A (Par-6 Family Cell Polarity Regulator Alpha) is a Protein Coding gene. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Insulin Pathway. GO annotations related to this gene include transcription factor binding and Rho GTPase binding. An important paralog of this gene is PARD6B.
UniProtKB/Swiss-Prot for PARD6A Gene
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).