Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PARD6A Gene

Aliases for PARD6A Gene

  • Par-6 Family Cell Polarity Regulator Alpha 2 3 5
  • Tax Interaction Protein 40 3 4
  • PAR-6 Alpha 3 4
  • PAR-6A 3 4
  • TIP-40 3 4
  • PAR6C 3 4
  • Par-6 (Partitioning Defective 6, C.Elegans) Homolog Alpha 2
  • Par-6 Partitioning Defective 6 Homolog Alpha (C. Elegans) 2
  • Par-6 Partitioning Defective 6 Homolog Alpha 3
  • Partitioning Defective 6 Homolog Alpha 3
  • Partitioning-Defective Protein 6 3
  • Tax-Interacting Protein 40 3
  • PAR6alpha 3
  • TAX40 3
  • PAR-6 4
  • PAR6A 4
  • PAR6 3

External Ids for PARD6A Gene

Previous GeneCards Identifiers for PARD6A Gene

  • GC16P058389
  • GC16P068072
  • GC16P067430
  • GC16P067471
  • GC16P066252
  • GC16P053567

Summaries for PARD6A Gene

Entrez Gene Summary for PARD6A Gene

  • This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARD6A Gene

PARD6A (Par-6 Family Cell Polarity Regulator Alpha) is a Protein Coding gene. Among its related pathways are Development A2B receptor- action via G-protein alpha s and Tight junction. GO annotations related to this gene include transcription factor binding and Rho GTPase binding. An important paralog of this gene is PARD6G.

UniProtKB/Swiss-Prot for PARD6A Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).

Gene Wiki entry for PARD6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD6A Gene

Genomics for PARD6A Gene

Regulatory Elements for PARD6A Gene

Enhancers for PARD6A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F067545 1.5 FANTOM5 Ensembl ENCODE 11.5 -112.9 -112858 5.3 HDGF WRNIP1 ARID4B ZNF2 YY1 ZNF121 ZNF143 SP5 MIER2 REST HSD11B2 CARMIL2 E2F4 RANBP10 ATP6V0D1 FAM65A THAP11 ACD PARD6A ENSG00000262514
GH16F067685 0.7 Ensembl 11.4 +24.8 24755 0.2 HDGF ARNT YY1 ZNF143 SP3 MXD4 ZHX2 KAT8 MBD2 ETV4 PARD6A ACD GFOD2 ENSG00000237718 CARMIL2 RANBP10 TSNAXIP1 PIR36768
GH16F067684 0.4 ENCODE 11.4 +23.9 23947 0.1 ZNF335 GATA3 PRDM10 ZBTB26 NR2F2 PARD6A ACD GFOD2 ENSG00000237718 CARMIL2 RANBP10 TSNAXIP1 PIR36768
GH16F067550 1.1 Ensembl ENCODE 11.3 -106.8 -106813 6.3 ZFP64 ZNF493 ZNF121 KLF7 FOS ZNF202 ZNF263 REST ZNF518A ZNF623 ZDHHC1 ENSG00000260465 CENPT E2F4 ENKD1 ENSG00000263276 ACD ENSG00000270165 FBXL8 KIAA0895L
GH16F067570 0.6 ENCODE 11.2 -89.0 -89013 2.1 ZNF362 JUND JUN FOS PRDM1 ATP6V0D1 ENSG00000237718 CARMIL2 ACD PARD6A FAM65A C16orf86 ENKD1 ZDHHC1 HSD11B2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PARD6A on UCSC Golden Path with GeneCards custom track

Promoters for PARD6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000509023 -446 2201 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 SP3 SP5

Genomic Location for PARD6A Gene

Chromosome:
16
Start:
67,660,946 bp from pter
End:
67,662,778 bp from pter
Size:
1,833 bases
Orientation:
Plus strand

Genomic View for PARD6A Gene

Genes around PARD6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARD6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARD6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD6A Gene

Proteins for PARD6A Gene

  • Protein details for PARD6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPB6-PAR6A_HUMAN
    Recommended name:
    Partitioning defective 6 homolog alpha
    Protein Accession:
    Q9NPB6
    Secondary Accessions:
    • O14911
    • Q9NPJ7

    Protein attributes for PARD6A Gene

    Size:
    346 amino acids
    Molecular mass:
    37388 Da
    Quaternary structure:
    • Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 (Thr-359 phosphorylated form) and PRKCI. Interacts with DCTN1 and PCM1 (PubMed:20719959).

    Three dimensional structures from OCA and Proteopedia for PARD6A Gene

    Alternative splice isoforms for PARD6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARD6A Gene

Post-translational modifications for PARD6A Gene

Other Protein References for PARD6A Gene

No data available for DME Specific Peptides for PARD6A Gene

Domains & Families for PARD6A Gene

Gene Families for PARD6A Gene

Protein Domains for PARD6A Gene

Suggested Antigen Peptide Sequences for PARD6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPB6

UniProtKB/Swiss-Prot:

PAR6A_HUMAN :
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Belongs to the PAR6 family.
Domain:
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • The PB1 domain mediates interactions with MAP2K5.
  • The PDZ domain mediates the interaction with CRB3.
  • Contains 1 PB1 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 pseudo-CRIB domain.
Family:
  • Belongs to the PAR6 family.
genes like me logo Genes that share domains with PARD6A: view

Function for PARD6A Gene

Molecular function for PARD6A Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).

Gene Ontology (GO) - Molecular Function for PARD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding IPI 10934474
GO:0008134 transcription factor binding TAS 9482110
GO:0017048 Rho GTPase binding IEA,ISS --
GO:0030742 GTP-dependent protein binding IEA,ISS --
genes like me logo Genes that share ontologies with PARD6A: view
genes like me logo Genes that share phenotypes with PARD6A: view

Animal Models for PARD6A Gene

MGI Knock Outs for PARD6A:

Animal Model Products

miRNA for PARD6A Gene

miRTarBase miRNAs that target PARD6A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARD6A Gene

Localization for PARD6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD6A Gene

Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism. {ECO:0000269 PubMed:20719959}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARD6A Gene COMPARTMENTS Subcellular localization image for PARD6A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PARD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005634 nucleus IEA,ISS --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 20719959
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PARD6A: view

Pathways & Interactions for PARD6A Gene

genes like me logo Genes that share pathways with PARD6A: view

SIGNOR curated interactions for PARD6A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PARD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0016032 viral process TAS 9482110
GO:0045217 cell-cell junction maintenance IEA,ISS --
genes like me logo Genes that share ontologies with PARD6A: view

Drugs & Compounds for PARD6A Gene

(3) Drugs for PARD6A Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for PARD6A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PARD6A: view

Transcripts for PARD6A Gene

Unigene Clusters for PARD6A Gene

Par-6 partitioning defective 6 homolog alpha (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARD6A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for PARD6A Gene

GeneLoc Exon Structure for
PARD6A
ECgene alternative splicing isoforms for
PARD6A

Expression for PARD6A Gene

mRNA expression in normal human tissues for PARD6A Gene

mRNA differential expression in normal tissues according to GTEx for PARD6A Gene

This gene is overexpressed in Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for PARD6A Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARD6A Gene



Protein tissue co-expression partners for PARD6A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARD6A Gene:

PARD6A

SOURCE GeneReport for Unigene cluster for PARD6A Gene:

Hs.112933

mRNA Expression by UniProt/SwissProt for PARD6A Gene:

Q9NPB6-PAR6A_HUMAN
Tissue specificity: Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
genes like me logo Genes that share expression patterns with PARD6A: view

Primer Products

Orthologs for PARD6A Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARD6A 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia PARD6A 34 35
  • 91.86 (n)
dog
(Canis familiaris)
Mammalia PARD6A 34 35
  • 91.52 (n)
mouse
(Mus musculus)
Mammalia Pard6a 34 16 35
  • 90.27 (n)
rat
(Rattus norvegicus)
Mammalia Pard6a 34
  • 89.28 (n)
oppossum
(Monodelphis domestica)
Mammalia PARD6A 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARD6A 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARD6A 34 35
  • 68.45 (n)
lizard
(Anolis carolinensis)
Reptilia PARD6A 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pard6a 34 35
  • 65.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta par-6 36 35
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea par-6 36 35
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7159 35
  • 40 (a)
OneToMany
Species where no ortholog for PARD6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PARD6A Gene

ENSEMBL:
Gene Tree for PARD6A (if available)
TreeFam:
Gene Tree for PARD6A (if available)

Paralogs for PARD6A Gene

Paralogs for PARD6A Gene

(3) SIMAP similar genes for PARD6A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PARD6A: view

Variants for PARD6A Gene

Sequence variations from dbSNP and Humsavar for PARD6A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs797045144 Pathogenic 67,659,786(-) AGGAG(-/AAG)GAGTT nc-transcript-variant, upstream-variant-2KB, cds-indel
rs112282767 -- 67,662,707(+) CACAG(C/T)GGGGG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs112600026 -- 67,661,701(+) GGCAG(C/T)CTCTG intron-variant, upstream-variant-2KB, reference, missense
rs112770259 -- 67,660,909(+) ACGTC(A/G)CGCTC upstream-variant-2KB
rs115108685 -- 67,662,443(+) AGTGA(C/T)GATGA upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PARD6A Gene

Variant ID Type Subtype PubMed ID
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv952046 CNV deletion 24416366

Variation tolerance for PARD6A Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARD6A Gene

Human Gene Mutation Database (HGMD)
PARD6A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARD6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARD6A Gene

Disorders for PARD6A Gene

Relevant External Links for PARD6A

Genetic Association Database (GAD)
PARD6A
Human Genome Epidemiology (HuGE) Navigator
PARD6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARD6A

No disorders were found for PARD6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARD6A Gene

Publications for PARD6A Gene

  1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PMID: 11260256) Noda Y. … Sumimoto H. (Genes Cells 2001) 2 3 4 22 64
  2. Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. (PMID: 19617897) Justilien V. … Fields A.P. (Oncogene 2009) 3 4 22 64
  3. Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains. (PMID: 15590654) Hirano Y. … Inagaki F. (J. Biol. Chem. 2005) 3 4 22 64
  4. A novel functional polymorphism (-336A/G) in the promoter of the partitioning-defective protein-6alpha gene is associated with increased glucose tolerance and lower concentrations of serum non-esterified fatty acids. (PMID: 15744531) Weyrich P. … Stefan N. (Diabetologia 2005) 3 22 46 64
  5. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PMID: 10934474) Joberty G. … Macara I.G. (Nat. Cell Biol. 2000) 3 4 22 64

Products for PARD6A Gene

Sources for PARD6A Gene

Content
Loading form....