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Aliases for PARD6A Gene

Aliases for PARD6A Gene

  • Par-6 Family Cell Polarity Regulator Alpha 2 3 5
  • Tax Interaction Protein 40 3 4
  • PAR-6 Alpha 3 4
  • PAR-6A 3 4
  • TIP-40 3 4
  • PAR6C 3 4
  • Par-6 (Partitioning Defective 6, C.Elegans) Homolog Alpha 2
  • Par-6 Partitioning Defective 6 Homolog Alpha (C. Elegans) 2
  • Par-6 Partitioning Defective 6 Homolog Alpha 3
  • Partitioning Defective-6 Homolog Alpha 3
  • Partitioning-Defective Protein 6 3
  • Tax-Interacting Protein 40 3
  • PAR6alpha 3
  • TAX40 3
  • PAR-6 4
  • PAR6A 4
  • PAR6 3

External Ids for PARD6A Gene

Previous GeneCards Identifiers for PARD6A Gene

  • GC16P058389
  • GC16P068072
  • GC16P067430
  • GC16P067471
  • GC16P066252
  • GC16P053567

Summaries for PARD6A Gene

Entrez Gene Summary for PARD6A Gene

  • This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARD6A Gene

PARD6A (Par-6 Family Cell Polarity Regulator Alpha) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include transcription factor binding and Rho GTPase binding. An important paralog of this gene is PARD6G.

UniProtKB/Swiss-Prot for PARD6A Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Gene Wiki entry for PARD6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD6A Gene

Genomics for PARD6A Gene

Regulatory Elements for PARD6A Gene

Promoters for PARD6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARD6A on UCSC Golden Path with GeneCards custom track

Genomic Location for PARD6A Gene

Chromosome:
16
Start:
67,660,946 bp from pter
End:
67,662,778 bp from pter
Size:
1,833 bases
Orientation:
Plus strand

Genomic View for PARD6A Gene

Genes around PARD6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARD6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARD6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD6A Gene

Proteins for PARD6A Gene

  • Protein details for PARD6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPB6-PAR6A_HUMAN
    Recommended name:
    Partitioning defective 6 homolog alpha
    Protein Accession:
    Q9NPB6
    Secondary Accessions:
    • O14911
    • Q9NPJ7

    Protein attributes for PARD6A Gene

    Size:
    346 amino acids
    Molecular mass:
    37388 Da
    Quaternary structure:
    • Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 (Thr-359 phosphorylated form) and PRKCI.

    Three dimensional structures from OCA and Proteopedia for PARD6A Gene

    Alternative splice isoforms for PARD6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARD6A Gene

Proteomics data for PARD6A Gene at MOPED

Post-translational modifications for PARD6A Gene

Other Protein References for PARD6A Gene

Antibody Products

No data available for DME Specific Peptides for PARD6A Gene

Domains & Families for PARD6A Gene

Gene Families for PARD6A Gene

Protein Domains for PARD6A Gene

Suggested Antigen Peptide Sequences for PARD6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPB6

UniProtKB/Swiss-Prot:

PAR6A_HUMAN :
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Belongs to the PAR6 family.
Domain:
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • The PB1 domain mediates interactions with MAP2K5.
  • The PDZ domain mediates the interaction with CRB3.
  • Contains 1 PB1 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 pseudo-CRIB domain.
Family:
  • Belongs to the PAR6 family.
genes like me logo Genes that share domains with PARD6A: view

Function for PARD6A Gene

Molecular function for PARD6A Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Gene Ontology (GO) - Molecular Function for PARD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017048 Rho GTPase binding IEA,ISS --
genes like me logo Genes that share ontologies with PARD6A: view
genes like me logo Genes that share phenotypes with PARD6A: view

Animal Model Products

miRNA for PARD6A Gene

miRTarBase miRNAs that target PARD6A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARD6A Gene

Localization for PARD6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD6A Gene

Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARD6A Gene COMPARTMENTS Subcellular localization image for PARD6A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PARD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IEA,ISS --
genes like me logo Genes that share ontologies with PARD6A: view

Pathways & Interactions for PARD6A Gene

genes like me logo Genes that share pathways with PARD6A: view

SIGNOR curated interactions for PARD6A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PARD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process TAS 9482110
GO:0060341 regulation of cellular localization IEA --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with PARD6A: view

Drugs & Compounds for PARD6A Gene

(2) Drugs for PARD6A Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for PARD6A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PARD6A: view

Transcripts for PARD6A Gene

Unigene Clusters for PARD6A Gene

Par-6 partitioning defective 6 homolog alpha (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARD6A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for PARD6A Gene

GeneLoc Exon Structure for
PARD6A
ECgene alternative splicing isoforms for
PARD6A

Expression for PARD6A Gene

mRNA expression in normal human tissues for PARD6A Gene

mRNA differential expression in normal tissues according to GTEx for PARD6A Gene

This gene is overexpressed in Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for PARD6A Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARD6A Gene



SOURCE GeneReport for Unigene cluster for PARD6A Gene Hs.112933

mRNA Expression by UniProt/SwissProt for PARD6A Gene

Q9NPB6-PAR6A_HUMAN
Tissue specificity: Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
genes like me logo Genes that share expression patterns with PARD6A: view

Protein tissue co-expression partners for PARD6A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PARD6A Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD6A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PARD6A 35
  • 91.86 (n)
  • 96.51 (a)
PARD6A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARD6A 35
  • 91.52 (n)
  • 95.66 (a)
PARD6A 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pard6a 35
  • 90.27 (n)
  • 93.06 (a)
Pard6a 16
Pard6a 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PARD6A 35
  • 99.81 (n)
  • 99.42 (a)
PARD6A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pard6a 35
  • 89.28 (n)
  • 92.46 (a)
oppossum
(Monodelphis domestica)
Mammalia PARD6A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARD6A 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARD6A 35
  • 68.45 (n)
  • 67.36 (a)
PARD6A 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARD6A 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pard6a 35
  • 65.99 (n)
  • 67.61 (a)
pard6a 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta par-6 37
  • 58 (a)
par-6 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea par-6 37
  • 52 (a)
par-6 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7159 36
  • 40 (a)
OneToMany
Species with no ortholog for PARD6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PARD6A Gene

ENSEMBL:
Gene Tree for PARD6A (if available)
TreeFam:
Gene Tree for PARD6A (if available)

Paralogs for PARD6A Gene

Paralogs for PARD6A Gene

(3) SIMAP similar genes for PARD6A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PARD6A: view

Variants for PARD6A Gene

Sequence variations from dbSNP and Humsavar for PARD6A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_050454 -

Structural Variations from Database of Genomic Variants (DGV) for PARD6A Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
dgv2890n71 CNV Loss 21882294
dgv2891n71 CNV Loss 21882294

Variation tolerance for PARD6A Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARD6A Gene

HapMap Linkage Disequilibrium report
PARD6A
Human Gene Mutation Database (HGMD)
PARD6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARD6A Gene

Disorders for PARD6A Gene

Relevant External Links for PARD6A

Genetic Association Database (GAD)
PARD6A
Human Genome Epidemiology (HuGE) Navigator
PARD6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARD6A

No disorders were found for PARD6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARD6A Gene

Publications for PARD6A Gene

  1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PMID: 11260256) Noda Y. … Sumimoto H. (Genes Cells 2001) 2 3 4 23 67
  2. Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. (PMID: 19617897) Justilien V. … Fields A.P. (Oncogene 2009) 3 23
  3. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. (PMID: 18562307) Hartleben B. … Huber T.B. (J. Biol. Chem. 2008) 3 23
  4. The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. (PMID: 18922891) Nolan M.E. … Muthuswamy S.K. (Cancer Res. 2008) 3 23
  5. Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota. (PMID: 16861740) Erdogan E. … Fields A.P. (J. Biol. Chem. 2006) 3 23

Products for PARD6A Gene

Sources for PARD6A Gene

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