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Aliases for PARD3 Gene

Aliases for PARD3 Gene

  • Par-3 Family Cell Polarity Regulator 2 3
  • PAR3 3 4 6
  • Atypical PKC Isotype-Specific Interacting Protein 2 3
  • Atypical PKC Isotype-Specific-Interacting Protein 3 4
  • Par-3 Family Cell Polarity Regulator Alpha 2 3
  • CTCL Tumor Antigen Se2-5 3 4
  • PAR3-Alpha 3 4
  • PARD-3 3 4
  • ASIP 3 4
  • Par-3 (Partitioning Defective 3, C.Elegans) Homolog 2
  • Par-3 Partitioning Defective 3 Homolog (C. Elegans) 2
  • Protein Phosphatase 1, Regulatory Subunit 118 3
  • Par-3 Partitioning Defective 3 Homolog 3
  • Partitioning Defective 3 Homolog 3
  • Regulatory Subunit 118 2
  • Protein Phosphatase 1 2
  • PAR3alpha 3
  • PPP1R118 3
  • SE2-5L16 3
  • SE2-5LT1 3
  • SE2-5T2 3
  • Bazooka 3
  • PARD3A 3
  • PAR-3 4
  • PAR3A 4
  • Baz 3

External Ids for PARD3 Gene

Summaries for PARD3 Gene

Entrez Gene Summary for PARD3 Gene

  • This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PARD3 Gene

PARD3 (Par-3 Family Cell Polarity Regulator) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein phosphatase binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot for PARD3 Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

Gene Wiki entry for PARD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD3 Gene

Genomics for PARD3 Gene

Genomic Location for PARD3 Gene

Start:
34,109,560 bp from pter
End:
34,815,325 bp from pter
Size:
705,766 bases
Orientation:
Minus strand

Genomic View for PARD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD3 Gene

Regulatory Elements for PARD3 Gene

Proteins for PARD3 Gene

  • Protein details for PARD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEW0-PARD3_HUMAN
    Recommended name:
    Partitioning defective 3 homolog
    Protein Accession:
    Q8TEW0
    Secondary Accessions:
    • F5H5T0
    • Q5T2U1
    • Q5VUA2
    • Q5VUA3
    • Q5VWV0
    • Q5VWV1
    • Q5VWV3
    • Q5VWV4
    • Q5VWV5
    • Q6IQ47
    • Q8TCZ9
    • Q8TEW1
    • Q8TEW2
    • Q8TEW3
    • Q96K28
    • Q96RM6
    • Q96RM7
    • Q9BY57
    • Q9BY58
    • Q9HC48
    • Q9NWL4
    • Q9NYE6

    Protein attributes for PARD3 Gene

    Size:
    1356 amino acids
    Molecular mass:
    151423 Da
    Quaternary structure:
    • Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus) (By similarity). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and AURKB. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Directly interacts with TIAM1 and TIAM2. Interacts with ECT2, FBF1 and SIRT2.
    Miscellaneous:
    • Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas
    SequenceCaution:
    • Sequence=AAG33676.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55330.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARD3 Gene

    Alternative splice isoforms for PARD3 Gene

neXtProt entry for PARD3 Gene

Proteomics data for PARD3 Gene at MOPED

Post-translational modifications for PARD3 Gene

  • Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination.
  • Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PARD3 Gene

Domains for PARD3 Gene

Protein Domains for PARD3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PARD3_HUMAN
Domain:
  • Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.:
    • Q8TEW0
  • The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.:
    • Q8TEW0
  • Contains 3 PDZ (DHR) domains.:
    • Q8TEW0
Family:
  • Belongs to the PAR3 family.:
    • Q8TEW0
genes like me logo Genes that share domains with PARD3: view

No data available for Gene Families for PARD3 Gene

Function for PARD3 Gene

Molecular function for PARD3 Gene

UniProtKB/Swiss-Prot Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

Gene Ontology (GO) - Molecular Function for PARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding IPI 10934474
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS --
GO:0019903 protein phosphatase binding IEA --
genes like me logo Genes that share ontologies with PARD3: view
genes like me logo Genes that share phenotypes with PARD3: view

Animal Models for PARD3 Gene

MGI Knock Outs for PARD3:

miRNA for PARD3 Gene

miRTarBase miRNAs that target PARD3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PARD3 Gene

Localization for PARD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD3 Gene

Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell membrane. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheat (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARD3 Gene COMPARTMENTS Subcellular localization image for PARD3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction ISS --
genes like me logo Genes that share ontologies with PARD3: view

Pathways for PARD3 Gene

genes like me logo Genes that share pathways with PARD3: view

Gene Ontology (GO) - Biological Process for PARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0003383 apical constriction IEA --
GO:0006461 protein complex assembly TAS 10934474
GO:0006612 protein targeting to membrane ISS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PARD3: view

Compounds for PARD3 Gene

(1) HMDB Compounds for PARD3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for PARD3 Gene

Compound -log(P) Hits PubMed IDs
pkcs 61 1
serine 3.31 1
genes like me logo Genes that share compounds with PARD3: view

Transcripts for PARD3 Gene

Unigene Clusters for PARD3 Gene

Par-3 partitioning defective 3 homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - -
SP13: -
SP14:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PARD3 Gene

GeneLoc Exon Structure for
PARD3
ECgene alternative splicing isoforms for
PARD3

Expression for PARD3 Gene

mRNA expression in normal human tissues for PARD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARD3 Gene

SOURCE GeneReport for Unigene cluster for PARD3 Gene Hs.131489

mRNA Expression by UniProt/SwissProt for PARD3 Gene

Q8TEW0-PARD3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with PARD3: view

Orthologs for PARD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARD3 36
  • 99.43 (n)
  • 99.63 (a)
PARD3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARD3 36
  • 89.77 (n)
  • 93.32 (a)
PARD3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARD3 36
  • 91.62 (n)
  • 94.82 (a)
PARD3 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pard3 36
  • 85.17 (n)
  • 91.37 (a)
Pard3 16
Pard3 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARD3 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARD3 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pard3 36
  • 85.04 (n)
  • 90.95 (a)
chicken
(Gallus gallus)
Aves PARD3 36
  • 82.06 (n)
  • 89.46 (a)
PARD3 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARD3 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16888 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pard3 36
  • 74.92 (n)
  • 80.21 (a)
Str.17665 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01071446.1 37
  • 64 (a)
OneToMany
Dr.26612 36
pard3 36
  • 65.22 (n)
  • 69.84 (a)
pard3 37
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta baz 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea par-3 37
  • 18 (a)
OneToMany
Species with no ortholog for PARD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARD3 Gene

ENSEMBL:
Gene Tree for PARD3 (if available)
TreeFam:
Gene Tree for PARD3 (if available)

Paralogs for PARD3 Gene

Paralogs for PARD3 Gene

Selected SIMAP similar genes for PARD3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PARD3 Gene

genes like me logo Genes that share paralogs with PARD3: view

Variants for PARD3 Gene

Sequence variations from dbSNP and Humsavar for PARD3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs447215 -- 34,353,366(-) ttagc(A/T)cagaa intron-variant
rs484833 -- 34,539,636(+) AGTTT(C/T)GGTGA intron-variant
rs493392 -- 34,542,959(+) GCCAT(C/G)AGAAC intron-variant
rs496660 -- 34,532,920(+) gagta(C/T)attac intron-variant
rs505537 -- 34,536,741(+) CTTTA(C/T)AGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARD3 Gene

Variant ID Type Subtype PubMed ID
nsv831830 CNV Gain 17160897
nsv524046 CNV Loss 19592680
esv2658802 CNV Deletion 23128226
nsv466859 CNV Loss 19166990
nsv442177 CNV CNV 18776908
nsv514552 CNV Loss 21397061
esv998100 CNV Insertion 20482838
esv2335600 CNV Deletion 18987734
esv269969 CNV Insertion 20981092
esv272084 CNV Insertion 20981092
esv267838 CNV Insertion 20981092
esv273183 CNV Insertion 20981092
esv7487 CNV Gain 19470904
dgv632n71 CNV Gain 21882294
nsv470930 CNV Gain 18288195
nsv528333 CNV Gain 19592680
nsv895011 CNV Loss 21882294
nsv466860 CNV Gain 19166990
esv2454597 CNV Deletion 19546169
esv2162225 CNV Deletion 18987734
esv2735295 CNV Deletion 23290073
esv2664780 CNV Deletion 23128226
nsv24936 CNV Loss 16902084
esv993510 CNV Deletion 20482838
esv1409307 CNV Deletion 17803354
nsv527577 CNV Loss 19592680
nsv895013 CNV Gain 21882294
esv22678 CNV Loss 19812545
esv2664452 CNV Deletion 23128226
nsv518288 CNV Gain 19592680
nsv895014 CNV Gain 21882294
nsv520991 CNV Loss 19592680
nsv525336 CNV Loss 19592680
nsv895015 CNV Gain 21882294
esv273634 CNV Insertion 20981092
nsv526446 CNV Loss 19592680
nsv466862 CNV Gain 19166990
nsv470931 CNV Gain 18288195
nsv521667 CNV Gain 19592680
nsv436113 CNV Deletion 17901297
dgv76n27 CNV Gain 19166990
dgv77n27 CNV Gain 19166990
esv272036 CNV Insertion 20981092
nsv466867 CNV Gain 19166990
nsv525060 CNV Gain 19592680
nsv24473 CNV Loss 16902084

Relevant External Links for PARD3 Gene

HapMap Linkage Disequilibrium report
PARD3
Human Gene Mutation Database (HGMD)
PARD3

Disorders for PARD3 Gene

Relevant External Links for PARD3

Genetic Association Database (GAD)
PARD3
Human Genome Epidemiology (HuGE) Navigator
PARD3
genes like me logo Genes that share disorders with PARD3: view

No data available for UniProtKB/Swiss-Prot for PARD3 Gene

Publications for PARD3 Gene

  1. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PMID: 10934474) Joberty G. … Macara I.G. (Nat. Cell Biol. 2000) 2 3 4 23
  2. Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. (PMID: 12234671) Gao L. … Joberty G. (Gene 2002) 3 4 23
  3. PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. (PMID: 12459187) Kohjima M. … Sumimoto H. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  4. The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. (PMID: 12953056) Ebnet K. … Vestweber D. (J. Cell. Sci. 2003) 3 23
  5. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. (PMID: 15723051) Nishimura T. … Kaibuchi K. (Nat. Cell Biol. 2005) 3 23

Products for PARD3 Gene

  • Addgene plasmids for PARD3

Sources for PARD3 Gene

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