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Aliases for PARD3 Gene

Aliases for PARD3 Gene

  • Par-3 Family Cell Polarity Regulator 2 3 5
  • Atypical PKC Isotype-Specific Interacting Protein 2 3
  • Protein Phosphatase 1, Regulatory Subunit 118 2 3
  • Par-3 Family Cell Polarity Regulator Alpha 2 3
  • CTCL Tumor Antigen Se2-5 3 4
  • PAR3-Alpha 3 4
  • PARD-3 3 4
  • PAR3 3 4
  • ASIP 3 4
  • Par-3 (Partitioning Defective 3, C.Elegans) Homolog 2
  • Par-3 Partitioning Defective 3 Homolog (C. Elegans) 2
  • Atypical PKC Isotype-Specific-Interacting Protein 4
  • Par-3 Partitioning Defective 3 Homolog 3
  • Partitioning Defective 3 Homolog 3
  • PAR3alpha 3
  • PPP1R118 3
  • SE2-5L16 3
  • SE2-5LT1 3
  • SE2-5T2 3
  • Bazooka 3
  • PARD3A 3
  • PAR-3 4
  • PAR3A 4
  • Baz 3

External Ids for PARD3 Gene

Previous GeneCards Identifiers for PARD3 Gene

  • GC10M034147
  • GC10M034548
  • GC10M034402
  • GC10M034404
  • GC10M034438

Summaries for PARD3 Gene

Entrez Gene Summary for PARD3 Gene

  • This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PARD3 Gene

PARD3 (Par-3 Family Cell Polarity Regulator) is a Protein Coding gene. Diseases associated with PARD3 include Gamma Heavy Chain Disease and Heavy Chain Disease. Among its related pathways are Tight junction and Hippo signaling pathway. GO annotations related to this gene include protein phosphatase binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot for PARD3 Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

Gene Wiki entry for PARD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARD3 Gene

Genomics for PARD3 Gene

Regulatory Elements for PARD3 Gene

Enhancers for PARD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F034789 1 Ensembl ENCODE 25.5 +25.2 25169 1.7 INSM2 CEBPG FEZF1 EBF1 BCL11B FOSL1 FOS ZNF639 SCRT1 MTA2 PARD3 PARD3-AS1 GC10M034800 PIR42782
GH10F034757 1.1 Ensembl ENCODE 22.6 +55.6 55607 5.3 HDGF CBX3 PKNOX1 ATF1 BMI1 ZNF48 ZNF121 ZNF366 SCRT2 FOS PARD3 PARD3-AS1 PIR42782 RPS12P16
GH10F034739 1.1 Ensembl ENCODE 17.7 +75.3 75343 1.7 KLF17 FEZF1 ZNF2 GLIS2 ZNF366 SCRT2 EGR2 ZNF263 ZNF362 ZEB2 PARD3 PARD3-AS1 PIR42782 RPS12P16
GH10F034768 1 Ensembl ENCODE 19.2 +46.5 46526 1.2 TBP KLF1 MAX SIN3A ZIC2 RAD21 YY1 ZFHX2 PRDM10 ZNF600 PARD3 PARD3-AS1 PIR42782 GC10M034800
GH10F034753 1.1 Ensembl ENCODE 17.2 +61.2 61197 2.3 HDGF PKNOX1 YBX1 ZNF121 KLF7 FOS CEBPB ZEB2 TBX21 RAD51 PARD3-AS1 PARD3 PIR42782 RPS12P16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARD3 on UCSC Golden Path with GeneCards custom track

Promoters for PARD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000353445 225 3001 PKNOX1 SIN3A RAD21 RARA GLIS2 ZNF366 SP3 SP5 TGIF2 ZFP69B

Genomic Location for PARD3 Gene

Chromosome:
10
Start:
34,109,560 bp from pter
End:
34,815,325 bp from pter
Size:
705,766 bases
Orientation:
Minus strand

Genomic View for PARD3 Gene

Genes around PARD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD3 Gene

Proteins for PARD3 Gene

  • Protein details for PARD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEW0-PARD3_HUMAN
    Recommended name:
    Partitioning defective 3 homolog
    Protein Accession:
    Q8TEW0
    Secondary Accessions:
    • F5H5T0
    • Q5T2U1
    • Q5VUA2
    • Q5VUA3
    • Q5VWV0
    • Q5VWV1
    • Q5VWV3
    • Q5VWV4
    • Q5VWV5
    • Q6IQ47
    • Q8TCZ9
    • Q8TEW1
    • Q8TEW2
    • Q8TEW3
    • Q96K28
    • Q96RM6
    • Q96RM7
    • Q9BY57
    • Q9BY58
    • Q9HC48
    • Q9NWL4
    • Q9NYE6

    Protein attributes for PARD3 Gene

    Size:
    1356 amino acids
    Molecular mass:
    151423 Da
    Quaternary structure:
    • Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus) (By similarity). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and AURKB. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Directly interacts with TIAM1 and TIAM2. Interacts with ECT2, FBF1 and SIRT2.
    Miscellaneous:
    • Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.
    SequenceCaution:
    • Sequence=AAG33676.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55330.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARD3 Gene

    Alternative splice isoforms for PARD3 Gene

neXtProt entry for PARD3 Gene

Post-translational modifications for PARD3 Gene

  • Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination.
  • Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PARD3

No data available for DME Specific Peptides for PARD3 Gene

Domains & Families for PARD3 Gene

Protein Domains for PARD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEW0

UniProtKB/Swiss-Prot:

PARD3_HUMAN :
  • Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.
  • Belongs to the PAR3 family.
Domain:
  • Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.
  • The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.
  • Contains 3 PDZ (DHR) domains.
Family:
  • Belongs to the PAR3 family.
genes like me logo Genes that share domains with PARD3: view

Function for PARD3 Gene

Molecular function for PARD3 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

Gene Ontology (GO) - Molecular Function for PARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10934474
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS --
GO:0008289 lipid binding IEA --
GO:0019903 protein phosphatase binding IEA --
genes like me logo Genes that share ontologies with PARD3: view
genes like me logo Genes that share phenotypes with PARD3: view

Animal Models for PARD3 Gene

MGI Knock Outs for PARD3:

Animal Model Products

miRNA for PARD3 Gene

miRTarBase miRNAs that target PARD3

Clone Products

  • Addgene plasmids for PARD3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARD3 Gene

Localization for PARD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD3 Gene

Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell membrane. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheat (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARD3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for PARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction ISS --
genes like me logo Genes that share ontologies with PARD3: view

Pathways & Interactions for PARD3 Gene

genes like me logo Genes that share pathways with PARD3: view

SIGNOR curated interactions for PARD3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 10934474
GO:0006612 protein targeting to membrane ISS --
GO:0007049 cell cycle IEA --
GO:0007163 establishment or maintenance of cell polarity TAS 14676191
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PARD3: view

Drugs & Compounds for PARD3 Gene

(2) Drugs for PARD3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for PARD3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PARD3: view

Transcripts for PARD3 Gene

Unigene Clusters for PARD3 Gene

Par-3 partitioning defective 3 homolog (C. elegans):
Representative Sequences:

Clone Products

  • Addgene plasmids for PARD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - -
SP13: -
SP14:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PARD3 Gene

GeneLoc Exon Structure for
PARD3
ECgene alternative splicing isoforms for
PARD3

Expression for PARD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.2), Cervix (15.6), and Adrenal (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARD3 Gene



Protein tissue co-expression partners for PARD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARD3 Gene:

PARD3

SOURCE GeneReport for Unigene cluster for PARD3 Gene:

Hs.131489

mRNA Expression by UniProt/SwissProt for PARD3 Gene:

Q8TEW0-PARD3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PARD3: view

Primer Products

No data available for mRNA differential expression in normal tissues for PARD3 Gene

Orthologs for PARD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARD3 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia PARD3 34 35
  • 91.62 (n)
oppossum
(Monodelphis domestica)
Mammalia PARD3 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARD3 34 35
  • 89.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PARD3 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pard3 34 16 35
  • 85.17 (n)
rat
(Rattus norvegicus)
Mammalia Pard3 34
  • 85.04 (n)
chicken
(Gallus gallus)
Aves PARD3 34 35
  • 82.06 (n)
lizard
(Anolis carolinensis)
Reptilia PARD3 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pard3 34
  • 74.92 (n)
Str.17665 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16888 34
zebrafish
(Danio rerio)
Actinopterygii pard3 34 35
  • 65.22 (n)
CABZ01071446.1 35
  • 64 (a)
OneToMany
Dr.26612 34
fruit fly
(Drosophila melanogaster)
Insecta baz 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea par-3 35
  • 18 (a)
OneToMany
Species where no ortholog for PARD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARD3 Gene

ENSEMBL:
Gene Tree for PARD3 (if available)
TreeFam:
Gene Tree for PARD3 (if available)

Paralogs for PARD3 Gene

Paralogs for PARD3 Gene

(4) SIMAP similar genes for PARD3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PARD3 Gene

genes like me logo Genes that share paralogs with PARD3: view

Variants for PARD3 Gene

Sequence variations from dbSNP and Humsavar for PARD3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs193920776 Uncertain significance 34,470,094(-) ACCTG(C/G/T)GACAG reference, synonymous-codon, missense
rs193920777 Uncertain significance 34,470,095(-) AACCT(G/T)CGACA reference, missense
rs193921017 Uncertain significance 34,450,347(-) CCAAT(A/G)GTGGG intron-variant, reference, missense
rs10082362 -- 34,624,164(+) ACTGC(G/T)TTTCA intron-variant
rs10082378 -- 34,753,014(+) TGGAA(A/G)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARD3 Gene

Variant ID Type Subtype PubMed ID
nsv525336 CNV loss 19592680
nsv525060 CNV gain 19592680
nsv524046 CNV loss 19592680
nsv521667 CNV gain 19592680
nsv520991 CNV loss 19592680
nsv518288 CNV gain 19592680
nsv514552 CNV loss 21397061
nsv479222 CNV novel sequence insertion 20440878
nsv476733 CNV novel sequence insertion 20440878
nsv470931 CNV gain 18288195
nsv470930 CNV gain 18288195
nsv466867 CNV gain 19166990
nsv466862 CNV gain 19166990
nsv466860 CNV gain 19166990
nsv466859 CNV loss 19166990
nsv442177 CNV loss 18776908
nsv436113 CNV deletion 17901297
nsv24936 CNV deletion 16902084
nsv24473 CNV deletion 16902084
nsv1154123 CNV deletion 26484159
nsv1137440 CNV deletion 24896259
nsv1129146 CNV insertion 24896259
nsv1113270 CNV deletion 24896259
nsv1113269 CNV deletion 24896259
nsv1069470 CNV deletion 25765185
nsv1054913 CNV gain 25217958
nsv1053112 CNV gain 25217958
nsv1050107 CNV loss 25217958
nsv1049893 CNV gain 25217958
nsv1046777 CNV loss 25217958
nsv1044684 CNV loss 25217958
nsv1040758 CNV gain 25217958
nsv1036536 CNV loss 25217958
esv998100 CNV insertion 20482838
esv993510 CNV deletion 20482838
esv7487 CNV gain 19470904
esv3622880 CNV gain 21293372
esv3622879 CNV gain 21293372
esv3622878 CNV loss 21293372
esv3622877 CNV loss 21293372
esv3622876 CNV gain 21293372
esv3622873 CNV gain 21293372
esv3622872 CNV loss 21293372
esv3622871 CNV loss 21293372
esv3622866 CNV loss 21293372
esv3622865 CNV gain 21293372
esv3578765 CNV loss 25503493
esv3578759 CNV loss 25503493
esv3578756 CNV loss 25503493
esv3576338 CNV gain 25503493
esv3546145 CNV deletion 23714750
esv3410238 CNV insertion 20981092
esv3409433 CNV insertion 20981092
esv3408456 CNV insertion 20981092
esv3373332 CNV insertion 20981092
esv3359910 CNV insertion 20981092
esv3357786 CNV insertion 20981092
esv3324317 CNV insertion 20981092
esv3309361 CNV mobile element insertion 20981092
esv3308910 CNV mobile element insertion 20981092
esv3307810 CNV mobile element insertion 20981092
esv3305692 CNV mobile element insertion 20981092
esv2735295 CNV deletion 23290073
esv2664780 CNV deletion 23128226
esv2664452 CNV deletion 23128226
esv2658802 CNV deletion 23128226
esv2454597 CNV deletion 19546169
esv2335600 CNV deletion 18987734
esv22678 CNV loss 19812545
esv2162225 CNV deletion 18987734
esv1409307 CNV deletion 17803354
dgv77n27 CNV gain 19166990
dgv76n27 CNV gain 19166990
dgv704n100 CNV gain 25217958
dgv703n100 CNV gain 25217958
dgv702n100 CNV gain 25217958
dgv395n106 CNV deletion 24896259
dgv394n106 CNV deletion 24896259
dgv201e212 CNV loss 25503493
dgv108e214 CNV loss 21293372
dgv1032n54 CNV gain 21841781
nsv958261 CNV deletion 24416366
nsv951538 CNV deletion 24416366
nsv951537 CNV duplication 24416366
nsv947825 CNV duplication 23825009
nsv831830 CNV gain 17160897
nsv550397 CNV gain 21841781
nsv550396 CNV gain 21841781
nsv550394 CNV gain 21841781
nsv550392 CNV gain 21841781
nsv550391 CNV gain 21841781
nsv550390 CNV loss 21841781
nsv528333 CNV gain 19592680
nsv527577 CNV loss 19592680
nsv526446 CNV loss 19592680

Variation tolerance for PARD3 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARD3 Gene

Human Gene Mutation Database (HGMD)
PARD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARD3 Gene

Disorders for PARD3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PARD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gamma heavy chain disease
  • franklin's disease
heavy chain disease
  • hcd
enamel caries
  • dental caries limited to enamel
body dysmorphic disorder
  • body dysmorphia
- elite association - COSMIC cancer census association via MalaCards
Search PARD3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PARD3

Genetic Association Database (GAD)
PARD3
Human Genome Epidemiology (HuGE) Navigator
PARD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARD3
genes like me logo Genes that share disorders with PARD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARD3 Gene

Publications for PARD3 Gene

  1. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PMID: 10934474) Joberty G. … Macara I.G. (Nat. Cell Biol. 2000) 2 3 4 22 64
  2. Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. (PMID: 12234671) Gao L. … Joberty G. (Gene 2002) 3 4 22 64
  3. PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. (PMID: 12459187) Kohjima M. … Sumimoto H. (Biochem. Biophys. Res. Commun. 2002) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for PARD3 Gene

Sources for PARD3 Gene

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