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PARD3 Gene

protein-coding   GIFtS: 64
GCID: GC10M034438

Par-3 Family Cell Polarity Regulator

(Previous names: par-3 (partitioning defective 3, C.elegans) homolog, par-3...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Par-3 Family Cell Polarity Regulator1 2     Baz2
PAR32 3 5     PAR3alpha2
Atypical PKC Isotype-Specific Interacting Protein1 2     PARD3A2
Par-3 Family Cell Polarity Regulator Alpha1 2     SE2-5L162
Atypical PKC Isotype-Specific-Interacting Protein2 3     SE2-5LT12
ASIP2 3     SE2-5T22
PAR3-alpha2 3     bazooka2
PARD-32 3     Par-3 Partitioning Defective 3 Homolog2
CTCL Tumor Antigen Se2-52 3     Partitioning Defective 3 Homolog2
Par-3 (Partitioning Defective 3, C.Elegans) Homolog1     PAR-33
Par-3 Partitioning Defective 3 Homolog (C. Elegans)1     PAR3A3

External Ids:    HGNC: 160511   Entrez Gene: 562882   Ensembl: ENSG000001484987   OMIM: 6067455   UniProtKB: Q8TEW03   

Export aliases for PARD3 gene to outside databases

Previous GC identifers: GC10M034147 GC10M034548 GC10M034402 GC10M034404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PARD3 Gene:
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members
and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple
alternatively spliced transcript variants have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for PARD3 Gene:
PARD3 (par-3 family cell polarity regulator) is a protein-coding gene. Diseases associated with PARD3 include neural tube defects, and cutaneous t cell lymphoma. GO annotations related to this gene include protein phosphatase binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot: PARD3_HUMAN, Q8TEW0
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a
central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By
similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing
tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C
proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal
neurons

Gene Wiki entry for PARD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PARD3 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   FOXL1   Roaz   E2F   E2F-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PARD3 promoter sequence
   Search Chromatin IP Primers for PARD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PARD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p11.22

PARD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PARD3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M034438:  view genomic region     (about GC identifiers)

Start:
34,398,488 bp from pter      End:
35,104,253 bp from pter
Size:
705,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PARD3_HUMAN, Q8TEW0 (See protein sequence)
Recommended Name: Partitioning defective 3 homolog  
Size: 1356 amino acids; 151423 Da
Subunit: Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Isoform 2, but not at least isoform 3
interacts with PRKCZ. Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus) (By
similarity). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Component of a complex
whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and
AURKB. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1.
Directly interacts with TIAM1 and TIAM2. Interacts with ECT2 and FBF1
Miscellaneous: Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas
Sequence caution: Sequence=AAG33676.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA91366.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB55330.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for PARD3:
2KOM (3D)    
Secondary accessions: F5H5T0 Q5T2U1 Q5VUA2 Q5VUA3 Q5VWV0 Q5VWV1 Q5VWV3 Q5VWV4 Q5VWV5 Q6IQ47
Q8TCZ9 Q8TEW1 Q8TEW2 Q8TEW3 Q96K28 Q96RM6 Q96RM7 Q9BY57 Q9BY58 Q9HC48 Q9NWL4 Q9NYE6
Alternative splicing: 11 isoforms:  Q8TEW0-1   Q8TEW0-2   Q8TEW0-3   Q8TEW0-4   Q8TEW0-5   Q8TEW0-6   Q8TEW0-7   Q8TEW0-8   
Q8TEW0-9   Q8TEW0-10   Q8TEW0-11   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PARD3: NX_Q8TEW0

Explore proteomics data for PARD3 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts
    during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6.
    EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA
    at Ser-962 is required for the normal establishment of neuronal polarity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PARD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001171714.1  NP_001171715.1  NP_001171716.1  NP_001171717.1  NP_001171718.1  NP_001171719.1  NP_001171720.1  NP_001171721.1  
    NP_001171722.1  NP_001171723.1  NP_062565.2  

    ENSEMBL proteins: 
     ENSP00000363921   ENSP00000363920   ENSP00000340591   ENSP00000363926   ENSP00000311986  
     ENSP00000363922   ENSP00000363908   ENSP00000363905   ENSP00000363900   ENSP00000443147  
     ENSP00000440857   ENSP00000341844   ENSP00000444429  
    Reactome Protein details: Q8TEW0

    PARD3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PARD3
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    Novus Biologicals PARD3 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PARD3

    PARD3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PARD3
    R&D Systems Antibodies for PARD3 (PARD3/Par3)
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    Abcam antibodies for PARD3
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    ThermoFisher Antibodies for PARD3
    LSBio Antibodies in human, mouse, rat for PARD3

    PARD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PARD3
    Cloud-Clone Corp. CLIAs for PARD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021922 DUF3534
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q8TEW0

    ProtoNet protein and cluster: Q8TEW0

    UniProtKB/Swiss-Prot: PARD3_HUMAN, Q8TEW0
    Domain: Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is
    essential for proper subapical membrane localization (By similarity)
    Domain: The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids (By
    similarity)
    Similarity: Belongs to the PAR3 family
    Similarity: Contains 3 PDZ (DHR) domains


    PARD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARD3_HUMAN, Q8TEW0
    Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a
    central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By
    similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing
    tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C
    proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal
    neurons

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI10934474
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS--
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding ISS--
    GO:0019903protein phosphatase binding IEA--
         
    PARD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PARD3:
     Increased S DNA content 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pard3):
     cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis 

    PARD3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pard3tm1.1Shoh for PARD3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PARD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PARD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PARD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PARD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PARD3:
    hsa-mir-93-3p (MIRT038900), hsa-mir-483-3p (MIRT006686), hsa-mir-766-3p (MIRT039030)

    Block miRNA regulation of human, mouse, rat PARD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PARD3 (see all 18):
    hsa-miR-137 hsa-let-7a-2* hsa-miR-624* hsa-miR-219-5p hsa-miR-508-3p hsa-miR-27b* hsa-miR-124 hsa-miR-641
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PARD3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 11): PARD3 (NM_001184793)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PARD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PARD3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PARD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PARD3_HUMAN, Q8TEW0: Endomembrane system. Cell junction. Cell junction, tight junction. Cell membrane. Cytoplasm,
    cell cortex (By similarity). Cytoplasm, cytoskeleton. Note=Localized along the cell-cell contact region.
    Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that
    overlays the meiotic spindle during metaphase I and metaphase II (By similarity). Presence of KRIT1, CDH5 and
    RAP1B is required for its localization to the cell junction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction ISS--

    PARD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PARD3 About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    3Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    4ERK Signaling
    Rho Family GTPases0.61
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PARD3
        Rac1 Pathway
    Epithelial Tight Junctions
    CDC42 Pathway
    Rho Family GTPases
    Epithelial Adherens Junctions

    1 BioSystems Pathway for PARD3
        TGF-beta Receptor Signaling Pathway

    2 Reactome Pathways for PARD3
        Tight junction interactions
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)


    Selected Kegg Pathways  (Kegg details for PARD3) (see all 7):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Neuroactive ligand-receptor interaction
    Endocytosis
    Hippo signaling pathway


    PARD3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARD3: 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PARD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PARD3 (Q8TEW01, 2, 3 ENSP000003639214) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F11RQ9Y6241, 2, 3EBI-81968,EBI-742600 MINT-4085346 MINT-4085691 I2D: score=4 
    PLCB3Q019702, 3, ENSP000002792304MINT-62362 MINT-62354 MINT-62363 MINT-62358 MINT-62361 I2D: score=3 STRING: ENSP00000279230
    TP53P046371, 2EBI-81968,EBI-366083 MINT-8415654 MINT-8415512 MINT-8415665
    PRKCIP417431, 3, ENSP000002957974EBI-81968,EBI-286199 I2D: score=7 STRING: ENSP00000295797
    SFNP319472, 3, ENSP000003409894MINT-3975121 I2D: score=3 STRING: ENSP00000340989
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0003383apical constriction IEA--
    GO:0006461protein complex assembly TAS10934474
    GO:0006612protein targeting to membrane ISS--
    GO:0007049cell cycle IEA--

    PARD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PARD3

    1 HMDB Compound for PARD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for PARD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 61 1 10934474 (1)
    serine 3.31 1 12953056 (1)



    PARD3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PARD3 gene (11 alternative transcripts): 
    NM_001184785.1  NM_001184786.1  NM_001184787.1  NM_001184788.1  NM_001184789.1  NM_001184790.1  NM_001184791.1  NM_001184792.1  
    NM_001184793.1  NM_001184794.1  NM_019619.3  

    Unigene Cluster for PARD3:

    Par-3 partitioning defective 3 homolog (C. elegans)
    Hs.131489  [show with all ESTs]
    Unigene Representative Sequence: NM_019619
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374789(uc010qej.2) ENST00000374788(uc010qek.2) ENST00000346874(uc010qel.2 uc001ixs.1 uc001ixu.2)
    ENST00000374794 ENST00000350537 ENST00000374790 ENST00000466092 ENST00000374776
    ENST00000374773 ENST00000374768 ENST00000545693(uc010qem.2 uc010qen.2 uc010qeo.2 uc010qeq.2)
    ENST00000545260(uc010qep.2) ENST00000340077(uc001ixr.2 uc001ixq.2 uc001ixp.2 uc001ixt.1)
    ENST00000544292(uc001ixo.2)
    miRNA
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    hsa-miR-137 hsa-let-7a-2* hsa-miR-624* hsa-miR-219-5p hsa-miR-508-3p hsa-miR-27b* hsa-miR-124 hsa-miR-641
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      QuantiFast Probe-based Assays in human, mouse, rat PARD3

    Additional mRNA sequence: 

    AB073671.1 AF177228.1 AF196185.1 AF196186.1 AF252293.1 AF332592.1 AF332593.1 AF467002.1 
    AF467003.1 AF467004.1 AF467005.1 AF467006.1 AK000761.1 AK024668.1 AK025892.1 AK027735.1 
    AK172827.1 BC011711.2 BC071566.1 

    22 DOTS entries:

    DT.100649152  DT.454019  DT.92439499  DT.100028403  DT.97847361  DT.95282374  DT.100743843  DT.100751779 
    DT.95282362  DT.100028401  DT.97770380  DT.97847364  DT.121302970  DT.121303027  DT.100751781  DT.102842662 
    DT.121303042  DT.95282364  DT.40109303  DT.87015991  DT.102842661  DT.99996790 

    Selected AceView cDNA sequences (see all 243):

    T10529 AK024668 AI497808 AF467004 BM674247 AB073671 AL041288 AI241357 
    CA487459 AI356239 AI990542 AI079538 BU553820 NM_019619 AW079553 BM824180 
    BC071566 AF467006 AA579931 AF467003 AF332592 BE707167 AX765712 BM981787 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PARD3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^
    SP1:                    -                             -     -                                                                             -                     
    SP2:                    -                             -     -                                                                                                   
    SP3:                    -                             -     -                                                     -                       -                     
    SP4:                    -                             -     -                                                                                                   
    SP5:                    -                             -     -                                                     -                       -                 -   

    ExUns: 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                          -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for PARD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PARD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGCGCAATA
    PARD3 Expression
    About this image


    PARD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Megakaryocytes Hematopoietic Bone Marrow
     
     Esophagus (Gastrointestinal Tract)
    PARD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PARD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131489

    UniProtKB/Swiss-Prot: PARD3_HUMAN, Q8TEW0
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PARD3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PARD3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pard31 , 5 par-3 (partitioning defective 3) homolog (C. elegans)5
    par-3 family cell polarity regulator1
    85.17(n)1
    91.37(a)1
      8 (74.66 cM)5
    937421  NM_033620.21  NP_296369.21 
     1270638935 
    chicken
    (Gallus gallus)
    Aves PARD31 par-3 partitioning defective 3 homolog (C. elegans) 82.06(n)
    89.46(a)
      420468  NM_001039280.2  NP_001034369.2 
    lizard
    (Anolis carolinensis)
    Reptilia PARD36
    par-3 family cell polarity regulator
    84(a)
    1 ↔ 1
    6(11025410-11524167)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168882 Xenopus laevis transcribed sequence with moderate similarity more 80.62(n)    48051074 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266122 Danio rerio ASIP mRNA, complete cds 76.56(n)    AF465629.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta baz6
    bazooka
    24(a)
    1 → many
    X(17054062-17089350)
    worm
    (Caenorhabditis elegans)
    Secernentea par-36
    Protein PAR-3, isoform b (par-3) mRNA, complete cd...
    18(a)
    1 → many
    III(5664234-5676732) WBGene00003918


    ENSEMBL Gene Tree for PARD3 (if available)
    TreeFam Gene Tree for PARD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PARD3 gene
    PARD3B2  IL162  PDZD22  INADL2  LNX22  MPDZ2  LNX12  
    4 SIMAP similar genes for PARD3 using alignment to 5 protein entries:     PARD3_HUMAN (see all proteins):
    ALS2CR19    DLG4    PARD3B    IL16

    PARD3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PARD3
    PGOHUM00000258468


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PARD3 (see all 14560)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939207761,2
    Cuntested134759022(-) ACCTGC/G/TGACAG 22 C W mis10--------
    rs758934211,2
    C,F--34397989(+) AGTCAT/CGGGAC 8 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs759823551,2
    C--34397990(+) GTCATA/GGGACT 8 -- int10--------
    rs344160491,2
    C,F--34398123(+) TGTCTC/TTCCCC 8 -- int14Minor allele frequency- T:0.04NA CSA WA 124
    rs1510888571,2
    C--34398157(+) AAATAC/TGCAAT 8 -- int10--------
    rs1425788771,2
    --34398331(+) CCCAGA/GGTTCT 8 -- int10--------
    rs732649751,2
    C--34398391(+) TTTCTC/TTAAAT 8 -- int13Minor allele frequency- T:0.24WA 122
    rs2018445141,2
    --34398395(+) TCTAA-/ATATAAA 8 -- int10--------
    rs2000643491,2
    C--34398396(+) CTAAA-/ATAAAA 8 -- int10--------
    rs794836531,2
    C,F--34398398(+) AAATAT/AAAAAA 8 -- int11Minor allele frequency- A:0.33NA 6

    HapMap Linkage Disequilibrium report for PARD3 (34398488 - 34648488 bp, first 250kb of PARD3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PARD3 (see all 46):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2162225CNV Deletion18987734
    esv993510CNV Deletion20482838
    esv2735295CNV Deletion23290073
    esv2658802CNV Deletion23128226
    esv2454597CNV Deletion19546169
    nsv436113CNV Deletion17901297
    esv2664780CNV Deletion23128226
    esv2664452CNV Deletion23128226
    esv2335600CNV Deletion18987734
    esv1409307CNV Deletion17803354

    Human Gene Mutation Database (HGMD): PARD3
    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PARD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606745    OMIM disorders: --

    18 diseases for PARD3:    
    About MalaCards
    neural tube defects    cutaneous t cell lymphoma    major depressive disorder    ulcerative colitis
    esophageal squamous cell carcinoma    crohn's disease    lymphoblastic leukemia    squamous cell carcinoma
    esophagitis    schizophrenia    hepatocellular carcinoma    alzheimer's disease
    leukemia    prostate cancer    prostatitis    endotheliitis
    breast cancer    neuronitis


    PARD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PARD3
    Human Genome Epidemiology (HuGE) Navigator: PARD3 (12 documents)

    Export disorders for PARD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PARD3 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with PARD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PubMed id 10934474)1, 2, 3, 9 Joberty G.... Macara I.G. (Nat. Cell Biol. 2000)
    2. Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. (PubMed id 12234671)1, 2, 9 Gao L.... Joberty G. (Gene 2002)
    3. PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. (PubMed id 12459187)1, 2, 9 Kohjima M.... Sumimoto H. (Biochem. Biophys. Res. Commun. 2002)
    4. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1, 4 Bhatti P....Sigurdson A.J. (Radiat. Res. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. (PubMed id 20096742)1, 4 Wolters V.M....Schreurs M.W. (Hum. Immunol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PubMed id 19684603)1, 4 Trevino L.R.... Relling M.V. (Nat. Genet. 2009)
    9. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (Physiol. Genomics 2009)
    10. Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora A and regulates its function in neuronal polarity. (PubMed id 19812038)1, 2 Khazaei M.R. and Puschel A.W. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56288 HGNC: 16051 AceView: PARD3 Ensembl:ENSG00000148498 euGenes: HUgn56288
    ECgene: PARD3 Kegg: 56288 H-InvDB: PARD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PARD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PARD3 gene:
    Search GeneIP for patents involving PARD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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