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PAQR8 Gene

protein-coding   GIFtS: 46
GCID: GC06P052226

Progestin And AdipoQ Receptor Family Member VIII

(Previous name: chromosome 6 open reading frame 33)
(Previous symbol: C6orf33)
  See PAQR8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Progestin And AdipoQ Receptor Family Member VIII1 2 3     Progestin And AdipoQ Receptor Family Member 82 3
C6orf331 2 3 5     MPR Beta2 3
LMPB12 3 5     Chromosome 6 Open Reading Frame 331
MPRB2 3 5     Lysosomal Membrane Protein In Brain-12
Lysosomal Membrane Protein In Brain 12 3     Membrane Progestin Receptor Beta2

External Ids:    HGNC: 157081   Entrez Gene: 853152   Ensembl: ENSG000001709157   OMIM: 6077805   UniProtKB: Q8TEZ73   

Export aliases for PAQR8 gene to outside databases

Previous GC identifers: GC06P052335 GC06P052058


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PAQR8 Gene:
PAQR8 (progestin and adipoQ receptor family member VIII) is a protein-coding gene. Diseases associated with PAQR8 include epilepsy with generalized tonic-clonic seizures. GO annotations related to this gene include steroid binding. An important paralog of this gene is PAQR7.

UniProtKB/Swiss-Prot: MPRB_HUMAN, Q8TEZ7
Function: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity)

Gene Wiki entry for PAQR8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAQR8 gene promoter:
         GR   ISGF-3   GR-beta   NRSF form 1   NRSF form 2   S8   Nkx6-1   IRF-7A   GR-alpha   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAQR8 promoter sequence
   Search Chromatin IP Primers for PAQR8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAQR8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12

PAQR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAQR8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P052226:  view genomic region     (about GC identifiers)

Start:
52,226,219 bp from pter      End:
52,272,575 bp from pter
Size:
46,357 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MPRB_HUMAN, Q8TEZ7 (See protein sequence)
Recommended Name: Membrane progestin receptor beta  
Size: 354 amino acids; 40464 Da
Sequence caution: Sequence=AAR08374.1; Type=Erroneous initiation; Sequence=CAC05478.1; Type=Erroneous initiation;
Secondary accessions: B2RCF6 Q86WL0 Q8N6D3 Q9HD02

Explore the universe of human proteins at neXtProt for PAQR8: NX_Q8TEZ7

Explore proteomics data for PAQR8 at MOPED


See PAQR8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_588608.1  
ENSEMBL proteins: 
 ENSP00000427161   ENSP00000406197   ENSP00000353953  

PAQR8 Human Recombinant Protein Products:

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Novus Biologicals PAQR8 Protein
Novus Biologicals PAQR8 Lysate
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Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for PAQR8 

PAQR8 Antibody Products:

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Novus Biologicals PAQR8 Antibody
Abcam antibodies for PAQR8
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibody for PAQR8
LSBio Antibodies in human, mouse, rat for PAQR8

PAQR8 Assay Products:

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Browse Enzo Life Sciences for kits & assays
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Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for PAQR8 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004254 HlyIII-related

Graphical View of Domain Structure for InterPro Entry Q8TEZ7

ProtoNet protein and cluster: Q8TEZ7

1 Blocks protein domain: IPB004254 Hly-III related proteins

UniProtKB/Swiss-Prot: MPRB_HUMAN, Q8TEZ7
Similarity: Belongs to the ADIPOR family


Find genes that share domains with PAQR8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MPRB_HUMAN, Q8TEZ7
Function: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003707steroid hormone receptor activity IBA--
GO:0005496steroid binding IBA--
     
Find genes that share ontologies with PAQR8           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for PAQR8:
 Decreased influenza A/WSN/33 r  Increased S DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAQR8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAQR8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAQR8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAQR8

miRNA
Products:
    
miRTarBase miRNAs that target PAQR8:
hsa-mir-326 (MIRT043654), hsa-mir-375 (MIRT019802), hsa-mir-335-5p (MIRT017929)

Block miRNA regulation of human, mouse, rat PAQR8 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate PAQR8 (see all 38):
hsa-miR-100* hsa-miR-4328 hsa-miR-765 hsa-miR-4305 hsa-miR-485-3p hsa-miR-138-2* hsa-miR-500a hsa-miR-877*
SwitchGear 3'UTR luciferase reporter plasmidPAQR8 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for PAQR8
Predesigned siRNA for gene silencing in human, mouse, rat PAQR8

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for PAQR8

Clone
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OriGene clones in human, mouse for PAQR8 (see all 7)
OriGene ORF clones in mouse, rat for PAQR8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PAQR8 (NM_133367)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAQR8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAQR8

Cell Line
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GenScript Custom overexpressing Cell Line Services for PAQR8
Browse ESI BIO Cell Lines and PureStem Progenitors for PAQR8 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAQR8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MPRB_HUMAN, Q8TEZ7: Cell membrane; Multi-pass membrane protein. Note=Colocalizes with a lysosomal protein
CTSD/cathepsin D
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IBA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with PAQR8           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAQR8
Interactions:

    Search GeneGlobe Interaction Network for PAQR8

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007275multicellular organismal development IEA--
GO:0030154cell differentiation IEA--
GO:0043401steroid hormone mediated signaling pathway IBA--
GO:0048477oogenesis IEA--
GO:0048545response to steroid hormone IBA--

Find genes that share ontologies with PAQR8           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PAQR8 (MPRB)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PAQR8 gene: 
NM_133367.4  

Unigene Cluster for PAQR8:

Progestin and adipoQ receptor family member VIII
Hs.239388  [show with all ESTs]
Unigene Representative Sequence: NM_133367
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000512121 ENST00000442253(uc003pao.4) ENST00000360726
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat PAQR8 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate PAQR8 (see all 38):
hsa-miR-100* hsa-miR-4328 hsa-miR-765 hsa-miR-4305 hsa-miR-485-3p hsa-miR-138-2* hsa-miR-500a hsa-miR-877*
SwitchGear 3'UTR luciferase reporter plasmidPAQR8 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for PAQR8
Predesigned siRNA for gene silencing in human, mouse, rat PAQR8
Clone
Products:
     
OriGene clones in human, mouse for PAQR8 (see all 7)
OriGene ORF clones in mouse, rat for PAQR8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PAQR8 (NM_133367)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAQR8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAQR8
Primer
Products:
    
OriGene qPCR primer pairs and template standards for PAQR8
OriGene qSTAR qPCR primer pairs in human, mouse for PAQR8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAQR8
  QuantiTect SYBR Green Assays in human, mouse, rat PAQR8
  QuantiFast Probe-based Assays in human, mouse, rat PAQR8

Additional mRNA sequence: 

AF313619.1 AF347029.1 AJ420470.1 AK057083.1 AK093603.1 AK128085.1 AK315088.1 AY424286.1 
BC030664.2 

5 DOTS entries:

DT.116140  DT.95097355  DT.100776455  DT.101980435  DT.97791371 

Selected AceView cDNA sequences (see all 143):

AW006774 T78976 BM704467 CA395770 BM729038 BM798375 BQ183737 AK128085 
BU736633 CD370786 BM681978 BQ016404 N39362 BF439998 AI950886 BM679731 
AI418869 AA662311 BF594216 CD558648 AA508695 AA948307 BE858249 BQ325629 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for PAQR8    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4
SP1:                        
SP2:        -     -         


ECgene alternative splicing isoforms for PAQR8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PAQR8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PAQR8 Expression
About this image

PAQR8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PAQR8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.239388

UniProtKB/Swiss-Prot: MPRB_HUMAN, Q8TEZ7
Tissue specificity: Expressed in brain and spinal cord. Also expressed in kidney and testis

    Custom PCR Arrays for PAQR8
Primer
Products:
OriGene qPCR primer pairs and template standards for PAQR8
OriGene qSTAR qPCR primer pairs in human, mouse for PAQR8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAQR8
QuantiTect SYBR Green Assays in human, mouse, rat PAQR8
QuantiFast Probe-based Assays in human, mouse, rat PAQR8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAQR8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PAQR8 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Paqr81 , 5 progestin and adipoQ receptor family member VIII1, 5 86.63(n)1
94.07(a)1
  1 (6.50 cM)5
742291  NM_028829.31  NP_083105.31 
 208906225 
chicken
(Gallus gallus)
Aves PAQR81 progestin and adipoQ receptor family member VIII 76.58(n)
82.15(a)
  422042  NM_001008462.1  NP_001008462.1 
African clawed frog
(Xenopus laevis)
Amphibia mpr-A-prov2 putative membrane progesterone receptor 74.17(n)    AY149119.1 
zebrafish
(Danio rerio)
Actinopterygii mprb2 membrane progestin receptor beta 73.52(n)   368254  AY149120.1 
worm
(Caenorhabditis elegans)
Secernentea K11C4.21 K11C4.2 40.05(n)
29.25(a)
  187288  NM_072349.2  NP_504750.2 


ENSEMBL Gene Tree for PAQR8 (if available)
TreeFam Gene Tree for PAQR8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PAQR8 gene
PAQR72  PAQR92  PAQR62  PAQR52  
1 SIMAP similar gene for PAQR8 using alignment to 3 protein entries:     MPRB_HUMAN (see all proteins):
PAQR7

Find genes that share paralogs with PAQR8           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PAQR8 (see all 926)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs47152981,2
C,H--52225036(+) ACTTGC/GAAACA 1 -- us2k1 tfbs39Minor allele frequency- G:0.01NA WA CSA 135
rs1148285051,2
F--52225096(+) ATGCAC/TGTTCA 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs1836579721,2
--52225274(+) GCTCCC/TGGCTG 1 -- us2k10--------
rs734439731,2
C--52225332(+) GCTAAC/ACTGTA 1 -- us2k12Minor allele frequency- A:0.07WA 120
rs1512074641,2
--52225382(+) ACTCCC/TTCTCA 1 -- us2k10--------
rs1409795251,2
--52225437(+) TTTGAC/TGATAA 1 -- us2k10--------
rs21472061,2
C,F,H--52225514(-) CTTTGC/TTCCCT 1 -- us2k119Minor allele frequency- T:0.37MN EA NS NA CSA WA 3584
rs789004201,2
C,F--52225533(+) GACCTC/TCTGTG 1 -- us2k11Minor allele frequency- T:0.17NA 120
rs1154471391,2
C--52225561(+) CACCTA/GTAAGT 1 -- us2k10--------
rs1149643141,2
C,F--52225799(+) ATTTTT/CGTATT 1 -- us2k11Minor allele frequency- C:0.15NA 120

HapMap Linkage Disequilibrium report for PAQR8 (52226219 - 52272575 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for PAQR8:    About this table    
Variant IDTypeSubtypePubMed ID
nsv527443CNV Loss19592680
esv21698CNV Gain19812545

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PAQR8
DNA2.0 Custom Variant and Variant Library Synthesis for PAQR8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607780    OMIM disorders: --

1 disease for PAQR8:    
About MalaCards
epilepsy with generalized tonic-clonic seizures

1 disease from the University of Copenhagen DISEASES database for PAQR8:
Epilepsy with generalized tonic-clonic seizures

Find genes that share disorders with PAQR8           About GenesLikeMe


Export disorders for PAQR8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PAQR8 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with PAQR8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein. (PubMed id 11676489)1, 2, 3, 9 Suzuki T.... Yamakawa K. (Biochem. Biophys. Res. Commun. 2001)
  2. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PubMed id 16044242)1, 2 Tang Y.T....Funk W.D. (J. Mol. Evol. 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The further redefining of steroid-mediated signaling. (PubMed id 12606724)1, 2 Hammes S.R. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  6. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. (PubMed id 12601167)1, 2 Zhu Y.... Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  8. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. (PubMed id 12574519)1, 3 Zhu Y....Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  10. Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. (PubMed id 21761364)1 Charles N.J....Lange C.A. (amp 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85315 HGNC: 15708 AceView: C6orf33 Ensembl:ENSG00000170915 euGenes: HUgn85315
ECgene: PAQR8 H-InvDB: PAQR8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PAQR8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PAQR8 gene:
Search GeneIP for patents involving PAQR8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PAQR8  
 OriGene qPCR primer pairs and template standards for PAQR8   OriGene Protein Over-expression Lysate for PAQR8  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for PAQR8  
 OriGene qSTAR qPCR primer pairs in human, mouse for PAQR8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for PAQR8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for PAQR8   OriGene Custom Protein Services for PAQR8  

 
 
 Block miRNA regulation of human, mouse, rat PAQR8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PAQR8
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAQR8 Predesigned siRNA for gene silencing in human, mouse, rat PAQR8
 QuantiFast Probe-based Assays in human, mouse, rat PAQR8 QuantiTect SYBR Green Assays in human, mouse, rat PAQR8
 Custom PCR Arrays for PAQR8 Search Chromatin IP Primers for PAQR8
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAQR8  Search GeneGlobe Interaction Network for PAQR8
 Regulatory tfbs in PAQR8 promoter
 GenScript Custom Purified and Recombinant Proteins Services for PAQR8 GenScript cDNA clones with any tag delivered in your preferred vector for PAQR8
 GenScript Custom Assay Services for PAQR8 GenScript Custom overexpressing Cell Line Services for PAQR8
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for PAQR8 (MPRB)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
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 4000+ Proteins
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 Protein Production Services
 Transfection Reagents
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 PAQR8 antibodies
 PAQR8 proteins
 PAQR8 lysates
 Antibodies for PAQR8
 See all of Abcam's Antibodies, Kits and Proteins for PAQR8
 Custom Antibody / Protein Production Service
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 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for PAQR8
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAQR8
 SwitchGear 3'UTR luciferase reporter plasmids for PAQR8
 SwitchGear Promoter luciferase reporter plasmids for PAQR8
 ThermoFisher Antibody for PAQR8
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAQR8
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAQR8
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAQR8
 LSBio Antibodies in human, mouse, rat for PAQR8
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for PAQR8
  Search eBioscience for proteins for PAQR8
  Search eBioscience for elisas for PAQR8
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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