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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PAQR7 Gene

protein-coding   GIFtS: 44
GCID: GC01M026187

progestin and adipoQ receptor family member VII

 Explore 4 diseases affiliated with
PAQR7 via our new
 Human Malady Compendium 
Biological research products
for PAQR7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Progestin And AdipoQ Receptor Family Member VII1 2 3     PGLP2 5
MPRA1 2 5     2310021M12Rik2
MSR1     Membrane Progestin Receptor Alpha2
Progestin And AdipoQ Receptor Family Member 72 3     MRPA3
MPR Alpha2 3     

External Ids:    HGNC: 231461   Entrez Gene: 1640912   Ensembl: ENSG000001827497   OMIM: 6077795   UniProtKB: Q86WK93   

Export aliases for PAQR7 gene to outside databases

Previous GC identifers: GC01M025872 GC01M026060 GC01M024443


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MPRA_HUMAN, Q86WK9
Function: Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PAQR7 gene promoter:
         Nkx3-1   Nkx3-1 v4   Sp1   NRSF form 1   MyoD   AP-4   Nkx3-1 v1   Egr-4   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAQR7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PAQR7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAQR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

PAQR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAQR7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M026187:  view genomic region     (about GC identifiers)

Start:
26,187,701 bp from pter      End:
26,197,744 bp from pter
Size:
10,044 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MPRA_HUMAN, Q86WK9 (See protein sequence)
Recommended Name: Membrane progestin receptor alpha  
Size: 346 amino acids; 39719 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A2A2D3 Q5XKF9 Q86VE4

Explore the universe of human proteins at neXtProt for PAQR7: NX_Q86WK9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86WK9

  • PAQR7 Protein expression data from MOPED and PaxDb:    About this image 
    PAQR7 Protein Expression
    REFSEQ proteins: NP_848509.1  
    ENSEMBL proteins: 
     ENSP00000363414  

    Human Recombinant Protein Products for PAQR7: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    PAQR7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PAQR7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004254 HlyIII-related

    Graphical View of Domain Structure for InterPro Entry Q86WK9

    ProtoNet protein and cluster: Q86WK9

    1 Blocks protein family: IPB004254 Hly-III related proteins

    UniProtKB/Swiss-Prot: MPRA_HUMAN, Q86WK9
    Similarity: Belongs to the ADIPOR family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPRA_HUMAN, Q86WK9
    Function: Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005496steroid binding IEA--
         
    PAQR7 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Paqr7 (no phenotypes)

    PAQR7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PAQR7 

    miRNA
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    hsa-miR-642a hsa-miR-137 hsa-miR-25 hsa-miR-200a hsa-miR-486-3p hsa-miR-3921 hsa-miR-3142 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidPAQR7 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAQR7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAQR7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PAQR7 (ENSP000003634144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--
    GO:0048477oogenesis IEA--

    PAQR7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PAQR7
    Search CenterWatch for drugs/clinical trials and news about PAQR7 / MPRA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PAQR7 gene: 
    NM_178422.5  

    Unigene Cluster for PAQR7:

    Progestin and adipoQ receptor family member VII
    Hs.523652  [show with all ESTs]
    Unigene Representative Sequence: BC034015
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374296(uc001bkx.3)

    miRNA
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    hsa-miR-642a hsa-miR-137 hsa-miR-25 hsa-miR-200a hsa-miR-486-3p hsa-miR-3921 hsa-miR-3142 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidPAQR7 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF313620.1 AY424285.1 BC034015.1 BC042298.2 BC127800.1 

    6 DOTS entries:

    DT.424801  DT.101980731  DT.102820785  DT.91722459  DT.100691952  DT.95339888 

    24/46 AceView cDNA sequences (see all 46):

    BM353680 BX359339 NM_178422 AY424285 BM352717 BC042298 AF313620 BM476343 
    BF326655 AA635590 BX355539 BF446877 BM803568 BX646155 BC034015 AA778580 
    BU950352 AA983543 BM722068 AW007804 BV198235 AI675437 BX114317 AA702295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PAQR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTCGGGCA
    PAQR7 Expression
    About this image

    PAQR7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PAQR7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PAQR7

    SOURCE GeneReport for Unigene cluster: Hs.523652

    UniProtKB/Swiss-Prot: MPRA_HUMAN, Q86WK9
    Tissue specificity: Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PAQR7 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PAQR71 progestin and adipoQ receptor family member VII 68.44(n)
    65.38(a)
      425505  NM_001163651.1  NP_001157123.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAQR76
    --
    58(a)
    1 ↔ 1
    GL343480.1(158868-159932)
    zebrafish
    (Danio rerio)
    Actinopterygii mpra2 membrane progestin receptor alpha 74.91(n)   368256  AY149121.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K11C4.21 Protein K11C4.2 41.92(n)
    28.14(a)
      187288  NM_072349.2  NP_504750.2 


    ENSEMBL Gene Tree for PAQR7 (if available)
    TreeFam Gene Tree for PAQR7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PAQR7 gene
    ADIPOR12  PAQR92  PAQR32  PAQR82  PAQR42  PAQR62  ADIPOR22  PAQR52  
    2 SIMAP similar genes for PAQR7 using alignment to 2 protein entries:     MPRA_HUMAN (see all proteins):
    PAQR8    PAQR5

    PAQR7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/217 NCBI SNPs in PAQR7 are shown (see all 217    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38063811,2
    C--26187898(-) CTGGGA/GCCCCT 1 -- ds5001 ese30--------
    rs120672751,2
    C,F,A,H--26187975(+) AGAGGT/CGGCTA 1 -- ut3123Minor allele frequency- C:0.16NS EA NA WA CSA 2356
    rs1865900801,2
    --26188028(+) CCCAGA/CCCCAA 1 -- ut310--------
    rs2136381,2
    C,F,A,H--26188238(+) CAGTGG/ACTCAT 1 -- ut31 ese317Minor allele frequency- A:0.45NS EA NA 1970
    rs1905786171,2
    --26188247(+) ATGCCA/GGTAAT 1 -- ut310--------
    rs1122143141,2
    C--26188318(+) CTGACG/CAACAT 1 -- ut311Minor allele frequency- C:0.50WA 2
    rs1391628851,2
    --26188338(+) CCGTCA/TCTACT 1 -- ut310--------
    rs1831573211,2
    --26188376(+) GTGGTA/GCATGC 1 -- ut310--------
    rs728794641,2
    C--26188610(+) CTGAAT/CGGATA 1 -- ut312Minor allele frequency- C:0.04WA 120
    rs2136371,2
    C,F,O,A,H--26188625(+) AATCCT/GTAACA 1 -- ut31 ese328Minor allele frequency- G:0.30MN NS EA NA WA CSA 2896

    HapMap Linkage Disequilibrium report for PAQR7 (26187701 - 26197744 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PAQR7: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PAQR7 for disorders           About GeneDecksing

    OMIM gene information: 607779    OMIM disorders: --

    4 diseases for PAQR7:    About MalaCards
    melioidosis    glanders    ovarian cancer    tuberculosis


    Export disorders for PAQR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PAQR7 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with PAQR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PubMed id 16044242)1, 2 Tang Y.T....Funk W.D. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The further redefining of steroid-mediated signaling. (PubMed id 12606724)1, 2 Hammes S.R. (2003)
    4. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. (PubMed id 12601167)1, 2 Zhu Y.... Thomas P. (2003)
    5. Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. (PubMed id 17082257)1, 9 Thomas P....Tubbs C. (2007)
    6. Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility. (PubMed id 19071147)1, 9 Thomas P....Garry V.F. (2009)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Expression of membrane progesterone receptors (mPR/PA QR) in ovarian cancer cells: implications for progesterone-induced signaling ev ents. (PubMed id 21761364)1 Charles N.J....Lange C.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 164091 HGNC: 23146 AceView: MPRA Ensembl:ENSG00000182749 euGenes: HUgn164091
    ECgene: PAQR7 H-InvDB: PAQR7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PAQR7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PAQR7 gene:
    Search GeneIP for patents involving PAQR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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    VWF
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    von Willebrand factor
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