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Aliases for PAQR7 Gene

Aliases for PAQR7 Gene

  • Progestin And AdipoQ Receptor Family Member 7 2 3 4 5
  • Progestin And AdipoQ Receptor Family Member VII 2 3 4
  • Membrane Progestin Receptor Alpha 2 3
  • MPR Alpha 3 4
  • 2310021M12Rik 3
  • MPRA 3
  • PGLP 3
  • MRPA 4
  • MSR 3

External Ids for PAQR7 Gene

Previous GeneCards Identifiers for PAQR7 Gene

  • GC01M026060
  • GC01M026187
  • GC01M024443

Summaries for PAQR7 Gene

GeneCards Summary for PAQR7 Gene

PAQR7 (Progestin And AdipoQ Receptor Family Member 7) is a Protein Coding gene. GO annotations related to this gene include steroid hormone receptor activity and steroid binding. An important paralog of this gene is PAQR8.

UniProtKB/Swiss-Prot for PAQR7 Gene

  • Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR7 Gene

Genomics for PAQR7 Gene

Regulatory Elements for PAQR7 Gene

Enhancers for PAQR7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F025995 1.2 ENCODE 11.7 -121.2 -121247 4.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 HMGN2 SYF2 ENSG00000207302 RPL17P9 LOC101928324 ENSG00000261349 FAM110D ENSG00000231953 RPL39P7 PAFAH2
GH01F025831 0.8 ENCODE 12 +44.3 44346 2.0 BCOR ESRRA PKNOX1 ZMYM3 ZNF121 ZNF335 GLIS2 POLR2A NCOR1 GATA2 SELENON PAQR7 ENSG00000207302 EXTL1 SLC30A2 PIR56916 PIR62460
GH01F025888 1.3 Ensembl ENCODE 7.1 -15.9 -15927 8.0 HDGF PKNOX1 ARNT ARID4B SIN3A CBX5 ZNF143 FOS KLF13 DEK SELENON MTFR1L PAFAH2 SYF2 ENSG00000252190 ENSG00000252691 EXTL1 RNU6-110P SLC30A2 TRIM63
GH01F025848 0.5 Ensembl 12.8 +27.8 27807 0.2 ADNP PRDM10 NR2C2 TRIM28 SELENON PAQR7 ENSG00000207302 EXTL1 TRIM63 FAM110D AUNIP PIR62460
GH01F025885 0.6 ENCODE 7.2 -9.5 -9509 2.3 GATAD2A BCOR ZNF362 ZNF384 ZNF121 BCL6 PRDM10 SMAD4 WT1 MTFR1L ENSG00000252190 ENSG00000252691 RNU6-110P EXTL1 SLC30A2 SELENON TRIM63 PAQR7 SNRPFP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAQR7 on UCSC Golden Path with GeneCards custom track

Promoters for PAQR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164200 1107 1601 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B FEZF1 DMAP1 SLC30A9 ZNF766

Genomic Location for PAQR7 Gene

Chromosome:
1
Start:
25,861,210 bp from pter
End:
25,876,707 bp from pter
Size:
15,498 bases
Orientation:
Minus strand

Genomic View for PAQR7 Gene

Genes around PAQR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR7 Gene

Proteins for PAQR7 Gene

  • Protein details for PAQR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK9-MPRA_HUMAN
    Recommended name:
    Membrane progestin receptor alpha
    Protein Accession:
    Q86WK9
    Secondary Accessions:
    • A2A2D3
    • Q5XKF9
    • Q86VE4

    Protein attributes for PAQR7 Gene

    Size:
    346 amino acids
    Molecular mass:
    39719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAQR7 Gene

Post-translational modifications for PAQR7 Gene

  • Ubiquitination at Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for PAQR7 Gene

No data available for DME Specific Peptides for PAQR7 Gene

Domains & Families for PAQR7 Gene

Gene Families for PAQR7 Gene

Protein Domains for PAQR7 Gene

Suggested Antigen Peptide Sequences for PAQR7 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WK9

UniProtKB/Swiss-Prot:

MPRA_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR7: view

Function for PAQR7 Gene

Molecular function for PAQR7 Gene

UniProtKB/Swiss-Prot Function:
Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.

Gene Ontology (GO) - Molecular Function for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IBA --
GO:0005496 steroid binding IEA,IBA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PAQR7: view
genes like me logo Genes that share phenotypes with PAQR7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PAQR7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAQR7 Gene

Localization for PAQR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR7 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR7: view

Pathways & Interactions for PAQR7 Gene

SuperPathways for PAQR7 Gene

No Data Available

Interacting Proteins for PAQR7 Gene

Gene Ontology (GO) - Biological Process for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0043401 steroid hormone mediated signaling pathway IEA --
GO:0048477 oogenesis IEA --
GO:0048545 response to steroid hormone IBA --
genes like me logo Genes that share ontologies with PAQR7: view

No data available for Pathways by source and SIGNOR curated interactions for PAQR7 Gene

Transcripts for PAQR7 Gene

Unigene Clusters for PAQR7 Gene

Progestin and adipoQ receptor family member VII:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR7 Gene

No ASD Table

Relevant External Links for PAQR7 Gene

GeneLoc Exon Structure for
PAQR7
ECgene alternative splicing isoforms for
PAQR7

Expression for PAQR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAQR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR7 Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for PAQR7 Gene

This gene is overexpressed in Testis (35.7), Placenta (17.6), and Ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAQR7 Gene



Protein tissue co-expression partners for PAQR7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAQR7 Gene:

PAQR7

SOURCE GeneReport for Unigene cluster for PAQR7 Gene:

Hs.523652

mRNA Expression by UniProt/SwissProt for PAQR7 Gene:

Q86WK9-MPRA_HUMAN
Tissue specificity: Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder.
genes like me logo Genes that share expression patterns with PAQR7: view

Primer Products

Orthologs for PAQR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR7 34 35
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia PAQR7 34 35
  • 89.73 (n)
dog
(Canis familiaris)
Mammalia PAQR7 34
  • 88.95 (n)
rat
(Rattus norvegicus)
Mammalia Paqr7 34
  • 83.87 (n)
mouse
(Mus musculus)
Mammalia Paqr7 34 16 35
  • 83.48 (n)
oppossum
(Monodelphis domestica)
Mammalia PAQR7 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAQR7 34 35
  • 68.44 (n)
lizard
(Anolis carolinensis)
Reptilia PAQR7 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii paqr7b 34 35
  • 60.95 (n)
mpra 34
worm
(Caenorhabditis elegans)
Secernentea K11C4.2 35
  • 25 (a)
OneToMany
Species where no ortholog for PAQR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PAQR7 Gene

ENSEMBL:
Gene Tree for PAQR7 (if available)
TreeFam:
Gene Tree for PAQR7 (if available)

Paralogs for PAQR7 Gene

Paralogs for PAQR7 Gene

(2) SIMAP similar genes for PAQR7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PAQR7: view

Variants for PAQR7 Gene

Sequence variations from dbSNP and Humsavar for PAQR7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111241153 -- 25,865,198(+) TTTCC(C/G)TGGCC intron-variant
rs111451589 -- 25,865,987(+) GTCTC(-/A)AAAAA intron-variant
rs111572157 -- 25,876,927(+) GGAAG(G/T)TTAGT upstream-variant-2KB
rs111776424 -- 25,866,818(+) ACCTC(C/T)GCCTC intron-variant
rs111810672 -- 25,865,893(+) AGGCA(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR7 Gene

Variant ID Type Subtype PubMed ID
nsv460884 CNV loss 19166990
nsv545883 CNV loss 21841781
nsv834491 CNV loss 17160897
nsv834502 CNV gain 17160897

Variation tolerance for PAQR7 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAQR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAQR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR7 Gene

Disorders for PAQR7 Gene

Relevant External Links for PAQR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAQR7

No disorders were found for PAQR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR7 Gene

Publications for PAQR7 Gene

  1. Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility. (PMID: 19071147) Thomas P. … Garry V.F. (Steroids 2009) 3 22 64
  2. Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. (PMID: 17082257) Thomas P. … Tubbs C. (Endocrinology 2007) 3 22 64
  3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. (PMID: 12601167) Zhu Y. … Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64

Products for PAQR7 Gene

Sources for PAQR7 Gene

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