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Aliases for PAQR7 Gene

Aliases for PAQR7 Gene

  • Progestin And AdipoQ Receptor Family Member 7 2 3 4
  • Progestin And AdipoQ Receptor Family Member VII 2 3 4 5
  • MPR Alpha 3 4
  • Membrane Progestin Receptor Alpha 2
  • 2310021M12Rik 3
  • MPRA 3
  • PGLP 3
  • MRPA 4
  • MSR 3

External Ids for PAQR7 Gene

Previous GeneCards Identifiers for PAQR7 Gene

  • GC01M026060
  • GC01M026187
  • GC01M024443

Summaries for PAQR7 Gene

GeneCards Summary for PAQR7 Gene

PAQR7 (Progestin And AdipoQ Receptor Family Member 7) is a Protein Coding gene. GO annotations related to this gene include steroid hormone receptor activity and steroid binding. An important paralog of this gene is PAQR6.

UniProtKB/Swiss-Prot for PAQR7 Gene

  • Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR7 Gene

Genomics for PAQR7 Gene

Regulatory Elements for PAQR7 Gene

Promoters for PAQR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAQR7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAQR7 Gene

Chromosome:
1
Start:
25,861,210 bp from pter
End:
25,876,707 bp from pter
Size:
15,498 bases
Orientation:
Minus strand

Genomic View for PAQR7 Gene

Genes around PAQR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR7 Gene

Proteins for PAQR7 Gene

  • Protein details for PAQR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK9-MPRA_HUMAN
    Recommended name:
    Membrane progestin receptor alpha
    Protein Accession:
    Q86WK9
    Secondary Accessions:
    • A2A2D3
    • Q5XKF9
    • Q86VE4

    Protein attributes for PAQR7 Gene

    Size:
    346 amino acids
    Molecular mass:
    39719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAQR7 Gene

Proteomics data for PAQR7 Gene at MOPED

Post-translational modifications for PAQR7 Gene

  • Ubiquitination at Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for PAQR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAQR7 Gene

Domains & Families for PAQR7 Gene

Gene Families for PAQR7 Gene

Protein Domains for PAQR7 Gene

Suggested Antigen Peptide Sequences for PAQR7 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WK9

UniProtKB/Swiss-Prot:

MPRA_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR7: view

Function for PAQR7 Gene

Molecular function for PAQR7 Gene

UniProtKB/Swiss-Prot Function:
Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.

Gene Ontology (GO) - Molecular Function for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IBA --
genes like me logo Genes that share ontologies with PAQR7: view
genes like me logo Genes that share phenotypes with PAQR7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PAQR7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAQR7 Gene

Localization for PAQR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAQR7 Gene COMPARTMENTS Subcellular localization image for PAQR7 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PAQR7 Gene

Pathways & Interactions for PAQR7 Gene

SuperPathways for PAQR7 Gene

No Data Available

Interacting Proteins for PAQR7 Gene

Gene Ontology (GO) - Biological Process for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048545 response to steroid hormone IBA --
genes like me logo Genes that share ontologies with PAQR7: view

No data available for Pathways by source and SIGNOR curated interactions for PAQR7 Gene

Drugs & Compounds for PAQR7 Gene

No Compound Related Data Available

Transcripts for PAQR7 Gene

Unigene Clusters for PAQR7 Gene

Progestin and adipoQ receptor family member VII:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR7 Gene

No ASD Table

Relevant External Links for PAQR7 Gene

GeneLoc Exon Structure for
PAQR7
ECgene alternative splicing isoforms for
PAQR7

Expression for PAQR7 Gene

mRNA expression in normal human tissues for PAQR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR7 Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for PAQR7 Gene

This gene is overexpressed in Testis (35.7), Placenta (17.6), and Ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAQR7 Gene



SOURCE GeneReport for Unigene cluster for PAQR7 Gene Hs.523652

mRNA Expression by UniProt/SwissProt for PAQR7 Gene

Q86WK9-MPRA_HUMAN
Tissue specificity: Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder.
genes like me logo Genes that share expression patterns with PAQR7: view

Protein tissue co-expression partners for PAQR7 Gene

Primer Products

In Situ Assay Products

Orthologs for PAQR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR7 36
  • 100 (a)
OneToOne
PAQR7 35
  • 99.42 (n)
  • 99.71 (a)
cow
(Bos Taurus)
Mammalia PAQR7 36
  • 90 (a)
OneToOne
PAQR7 35
  • 89.73 (n)
  • 91.57 (a)
dog
(Canis familiaris)
Mammalia PAQR7 35
  • 88.95 (n)
  • 91.28 (a)
mouse
(Mus musculus)
Mammalia Paqr7 16
Paqr7 36
  • 83 (a)
OneToOne
Paqr7 35
  • 83.48 (n)
  • 83.09 (a)
oppossum
(Monodelphis domestica)
Mammalia PAQR7 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paqr7 35
  • 83.87 (n)
  • 84.84 (a)
chicken
(Gallus gallus)
Aves PAQR7 35
  • 68.44 (n)
  • 65.38 (a)
PAQR7 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAQR7 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii paqr7b 36
  • 54 (a)
OneToOne
mpra 35
paqr7b 35
  • 60.95 (n)
  • 55.81 (a)
worm
(Caenorhabditis elegans)
Secernentea K11C4.2 36
  • 25 (a)
OneToMany
Species with no ortholog for PAQR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PAQR7 Gene

ENSEMBL:
Gene Tree for PAQR7 (if available)
TreeFam:
Gene Tree for PAQR7 (if available)

Paralogs for PAQR7 Gene

Paralogs for PAQR7 Gene

(2) SIMAP similar genes for PAQR7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PAQR7: view

Variants for PAQR7 Gene

Sequence variations from dbSNP and Humsavar for PAQR7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6689014 - 25,863,026(+) CTGCC(C/T)GAAGA reference, missense
rs55948644 - 25,863,161(+) GGACA(C/T)GAAGA reference, missense
rs190043 -- 25,874,111(+) ctccc(A/G)acctc intron-variant
rs213623 -- 25,876,233(+) GGAAT(C/G)CCTTC intron-variant, upstream-variant-2KB
rs213624 -- 25,874,673(+) CCATC(A/G)AACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR7 Gene

Variant ID Type Subtype PubMed ID
nsv834491 CNV Loss 17160897
nsv460884 CNV Loss 19166990
nsv834502 CNV Gain 17160897
nsv871062 CNV Gain 21882294

Variation tolerance for PAQR7 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAQR7 Gene

HapMap Linkage Disequilibrium report
PAQR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR7 Gene

Disorders for PAQR7 Gene

Relevant External Links for PAQR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAQR7

No disorders were found for PAQR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR7 Gene

Publications for PAQR7 Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 3 4 67
  2. Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility. (PMID: 19071147) Thomas P. … Garry V.F. (Steroids 2009) 3 23
  3. Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. (PMID: 17082257) Thomas P. … Tubbs C. (Endocrinology 2007) 3 23
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. (PMID: 21761364) Charles N.J. … Lange C.A. (Horm Cancer 2010) 3

Products for PAQR7 Gene

Sources for PAQR7 Gene

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