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Aliases for PAQR7 Gene

Aliases for PAQR7 Gene

  • Progestin And AdipoQ Receptor Family Member VII 2 3 4
  • Progestin And AdipoQ Receptor Family Member 7 3 4
  • Membrane Progestin Receptor Alpha 2 3
  • MPR Alpha 3 4
  • MPRA 3 6
  • PGLP 3 6
  • 2310021M12Rik 3
  • MRPA 4
  • MSR 3

External Ids for PAQR7 Gene

Previous GeneCards Identifiers for PAQR7 Gene

  • GC01M026060
  • GC01M026187
  • GC01M024443

Summaries for PAQR7 Gene

GeneCards Summary for PAQR7 Gene

PAQR7 (Progestin And AdipoQ Receptor Family Member VII) is a Protein Coding gene. GO annotations related to this gene include steroid binding. An important paralog of this gene is PAQR6.

UniProtKB/Swiss-Prot for PAQR7 Gene

  • Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR7 Gene

Genomics for PAQR7 Gene

Regulatory Elements for PAQR7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PAQR7 Gene

Start:
25,861,210 bp from pter
End:
25,875,970 bp from pter
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for PAQR7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAQR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR7 Gene

Proteins for PAQR7 Gene

  • Protein details for PAQR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK9-MPRA_HUMAN
    Recommended name:
    Membrane progestin receptor alpha
    Protein Accession:
    Q86WK9
    Secondary Accessions:
    • A2A2D3
    • Q5XKF9
    • Q86VE4

    Protein attributes for PAQR7 Gene

    Size:
    346 amino acids
    Molecular mass:
    39719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAQR7 Gene

Proteomics data for PAQR7 Gene at MOPED

Post-translational modifications for PAQR7 Gene

  • Ubiquitination at Lys197
  • Modification sites at PhosphoSitePlus

Other Protein References for PAQR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAQR7 Gene

Domains for PAQR7 Gene

Protein Domains for PAQR7 Gene

Suggested Antigen Peptide Sequences for PAQR7 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WK9

UniProtKB/Swiss-Prot:

MPRA_HUMAN :
  • Q86WK9
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR7: view

No data available for Gene Families for PAQR7 Gene

Function for PAQR7 Gene

Molecular function for PAQR7 Gene

UniProtKB/Swiss-Prot Function:
Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.

Gene Ontology (GO) - Molecular Function for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IBA --
GO:0005496 steroid binding IBA --
genes like me logo Genes that share ontologies with PAQR7: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAQR7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PAQR7 Gene

Localization for PAQR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAQR7 Gene COMPARTMENTS Subcellular localization image for PAQR7 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR7: view

Pathways for PAQR7 Gene

SuperPathways for PAQR7 Gene

No Data Available

Interacting Proteins for PAQR7 Gene

Gene Ontology (GO) - Biological Process for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0043401 steroid hormone mediated signaling pathway IBA --
GO:0048477 oogenesis IEA --
GO:0048545 response to steroid hormone IBA --
genes like me logo Genes that share ontologies with PAQR7: view

No data available for Pathways by source for PAQR7 Gene

Transcripts for PAQR7 Gene

Unigene Clusters for PAQR7 Gene

Progestin and adipoQ receptor family member VII:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAQR7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR7 Gene

No ASD Table

Relevant External Links for PAQR7 Gene

GeneLoc Exon Structure for
PAQR7
ECgene alternative splicing isoforms for
PAQR7

Expression for PAQR7 Gene

mRNA expression in normal human tissues for PAQR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR7 Gene

This gene is overexpressed in Testis (5.6).

Protein differential expression in normal tissues for PAQR7 Gene

This gene is overexpressed in Testis (35.7), Placenta (17.6), and Ovary (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAQR7 Gene

SOURCE GeneReport for Unigene cluster for PAQR7 Gene Hs.523652

mRNA Expression by UniProt/SwissProt for PAQR7 Gene

Q86WK9-MPRA_HUMAN
Tissue specificity: Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder.
genes like me logo Genes that share expressions with PAQR7: view

Expression partners for PAQR7 Gene

In Situ Assay Products

Orthologs for PAQR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAQR7 35
  • 89.73 (n)
  • 91.57 (a)
PAQR7 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAQR7 35
  • 88.95 (n)
  • 91.28 (a)
mouse
(Mus musculus)
Mammalia Paqr7 35
  • 83.48 (n)
  • 83.09 (a)
Paqr7 16
Paqr7 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAQR7 35
  • 99.42 (n)
  • 99.71 (a)
PAQR7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paqr7 35
  • 83.87 (n)
  • 84.84 (a)
oppossum
(Monodelphis domestica)
Mammalia PAQR7 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAQR7 35
  • 68.44 (n)
  • 65.38 (a)
PAQR7 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAQR7 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mpra 35
paqr7b 35
  • 60.95 (n)
  • 55.81 (a)
paqr7b 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K11C4.2 36
  • 25 (a)
OneToMany
Species with no ortholog for PAQR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PAQR7 Gene

ENSEMBL:
Gene Tree for PAQR7 (if available)
TreeFam:
Gene Tree for PAQR7 (if available)

Paralogs for PAQR7 Gene

Paralogs for PAQR7 Gene

Selected SIMAP similar genes for PAQR7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PAQR7: view

Variants for PAQR7 Gene

Sequence variations from dbSNP and Humsavar for PAQR7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs190043 -- 25,874,111(+) ctccc(A/G)acctc intron-variant
rs213622 -- 25,876,606(+) GAATT(A/T)AAAAA upstream-variant-2KB
rs213623 -- 25,876,233(+) GGAAT(C/G)CCTTC upstream-variant-2KB
rs213624 -- 25,874,673(+) CCATC(A/G)AACTG intron-variant
rs213636 -- 25,865,419(+) cctgt(A/G)atccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR7 Gene

Variant ID Type Subtype PubMed ID
nsv834491 CNV Loss 17160897
nsv460884 CNV Loss 19166990
nsv834502 CNV Gain 17160897
nsv871062 CNV Gain 21882294

Relevant External Links for PAQR7 Gene

HapMap Linkage Disequilibrium report
PAQR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR7 Gene

Disorders for PAQR7 Gene

No disorders were found for PAQR7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PAQR7 Gene

Publications for PAQR7 Gene

  1. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. (PMID: 12601167) Zhu Y. … Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  2. The further redefining of steroid-mediated signaling. (PMID: 12606724) Hammes S.R. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 3 4
  5. Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. (PMID: 17082257) Thomas P. … Tubbs C. (Endocrinology 2007) 3 23

Products for PAQR7 Gene

Sources for PAQR7 Gene

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