Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PAQR5 Gene

Aliases for PAQR5 Gene

  • Progestin And AdipoQ Receptor Family Member 5 2 3 4 5
  • Progestin And AdipoQ Receptor Family Member V 2 3 4
  • Membrane Progestin Receptor Gamma 2 3
  • MPR Gamma 3 4
  • MPRG 3 4

External Ids for PAQR5 Gene

Previous GeneCards Identifiers for PAQR5 Gene

  • GC15P067379
  • GC15P069591
  • GC15P046424

Summaries for PAQR5 Gene

GeneCards Summary for PAQR5 Gene

PAQR5 (Progestin And AdipoQ Receptor Family Member 5) is a Protein Coding gene. GO annotations related to this gene include receptor activity and steroid binding. An important paralog of this gene is PAQR8.

UniProtKB/Swiss-Prot for PAQR5 Gene

  • Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR5 Gene

Genomics for PAQR5 Gene

Regulatory Elements for PAQR5 Gene

Enhancers for PAQR5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G069303 1.5 Ensembl ENCODE dbSUPER 16 +5.9 5925 3.5 PKNOX1 ZFP64 SIN3A FEZF1 BRCA1 ELK1 FOS SP5 SMARCB1 MAFF PAQR5 GC15M069327
GH15G069299 1.3 ENCODE dbSUPER 10.2 +1.1 1124 1.0 HNRNPUL1 PKNOX1 FOXA2 ATF1 MLX FEZF1 ZNF2 TCF12 FOS SP5 PAQR5 GC15M069327
GH15G069357 1 Ensembl ENCODE 10.9 +60.2 60215 2.4 CTCF KLF1 TAL1 ZNF384 RAD21 THRB ZNF316 SCRT2 NR2F6 NFE2 PAQR5 ENSG00000259645 GC15M069327
GH15G069125 1.6 Ensembl ENCODE dbSUPER 6.5 -171.7 -171662 4.5 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B YY1 SP5 ZHX2 REST PAQR5 GC15M069102 ENSG00000259222
GH15G069298 1.1 ENCODE dbSUPER 9.3 +0.0 45 1.0 FOXA2 ZSCAN4 ZNF76 SIN3A GLIS2 SCRT2 EGR2 SP3 SMARCC1 ZNF174 PAQR5 GC15M069327
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAQR5 on UCSC Golden Path with GeneCards custom track

Promoters for PAQR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078609 198 601 ZSCAN4 ZNF76 SIN3A GLIS2 EGR2 SP3 SMARCC1 ZNF174 USF2 ZNF398

Genomic Location for PAQR5 Gene

69,298,902 bp from pter
69,407,780 bp from pter
108,879 bases
Plus strand

Genomic View for PAQR5 Gene

Genes around PAQR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR5 Gene

Proteins for PAQR5 Gene

  • Protein details for PAQR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane progestin receptor gamma
    Protein Accession:
    Secondary Accessions:
    • Q8IXU2

    Protein attributes for PAQR5 Gene

    330 amino acids
    Molecular mass:
    38014 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAQR5 Gene

Post-translational modifications for PAQR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PAQR5 Gene

Domains & Families for PAQR5 Gene

Gene Families for PAQR5 Gene

Protein Domains for PAQR5 Gene

Suggested Antigen Peptide Sequences for PAQR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ADIPOR family.
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR5: view

Function for PAQR5 Gene

Molecular function for PAQR5 Gene

UniProtKB/Swiss-Prot Function:
Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.

Gene Ontology (GO) - Molecular Function for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IBA --
GO:0005496 steroid binding IEA,IBA --
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PAQR5: view
genes like me logo Genes that share phenotypes with PAQR5: view

Animal Model Products

CRISPR Products

miRNA for PAQR5 Gene

miRTarBase miRNAs that target PAQR5

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAQR5 Gene

Localization for PAQR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR5 gene
Compartment Confidence
plasma membrane 4
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR5: view

Pathways & Interactions for PAQR5 Gene

SuperPathways for PAQR5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0043401 steroid hormone mediated signaling pathway IEA --
GO:0048477 oogenesis IEA --
GO:0048545 response to steroid hormone IBA --
genes like me logo Genes that share ontologies with PAQR5: view

No data available for Pathways by source and SIGNOR curated interactions for PAQR5 Gene

Drugs & Compounds for PAQR5 Gene

No Compound Related Data Available

Transcripts for PAQR5 Gene

Unigene Clusters for PAQR5 Gene

Progestin and adipoQ receptor family member V:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -

Relevant External Links for PAQR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAQR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAQR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR5 Gene

This gene is overexpressed in Kidney - Cortex (x10.0), Adrenal Gland (x6.5), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for PAQR5 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAQR5 Gene

Protein tissue co-expression partners for PAQR5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAQR5 Gene:


SOURCE GeneReport for Unigene cluster for PAQR5 Gene:


mRNA Expression by UniProt/SwissProt for PAQR5 Gene:

Tissue specificity: Expressed in the brain, lung, kidney, colon, adrenal and lung.

Evidence on tissue expression from TISSUES for PAQR5 Gene

  • Kidney(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with PAQR5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAQR5 Gene

Orthologs for PAQR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PAQR5 34 35
  • 99.39 (n)
(Canis familiaris)
Mammalia PAQR5 34 35
  • 89.6 (n)
(Mus musculus)
Mammalia Paqr5 34 16 35
  • 88.38 (n)
(Rattus norvegicus)
Mammalia Paqr5 34
  • 88.28 (n)
(Bos Taurus)
Mammalia PAQR5 34 35
  • 86.16 (n)
(Monodelphis domestica)
Mammalia PAQR5 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia PAQR5 35
  • 60 (a)
(Gallus gallus)
Aves PAQR5 34 35
  • 66.55 (n)
(Anolis carolinensis)
Reptilia PAQR5 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr5 34
  • 62.8 (n)
(Danio rerio)
Actinopterygii paqr5b 34 35
  • 63.37 (n)
paqr5a 35
  • 50 (a)
zgc56016 34
(Caenorhabditis elegans)
Secernentea K11C4.2 35
  • 22 (a)
Species where no ortholog for PAQR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR5 Gene

Gene Tree for PAQR5 (if available)
Gene Tree for PAQR5 (if available)

Paralogs for PAQR5 Gene

Paralogs for PAQR5 Gene

(2) SIMAP similar genes for PAQR5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PAQR5: view

Variants for PAQR5 Gene

Sequence variations from dbSNP and Humsavar for PAQR5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000059095 -- 69,324,874(+) CTCTT(C/T)AAGAC intron-variant
rs1000065739 -- 69,311,457(+) GTGGC(A/G)TTTGT intron-variant
rs1000068032 -- 69,365,398(+) CCACC(A/G/T)TGCCC intron-variant
rs1000105790 -- 69,394,154(+) AAAAA(-/CCT)CCTGG intron-variant
rs1000165058 -- 69,333,870(+) TTCAT(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR5 Gene

Variant ID Type Subtype PubMed ID
dgv1438e59 CNV duplication 20981092
esv1010893 CNV deletion 20482838
esv1243241 CNV deletion 17803354
esv2092169 CNV deletion 18987734
esv2343800 CNV deletion 18987734
esv2659982 CNV deletion 23128226
esv2663165 CNV deletion 23128226
esv2675617 CNV deletion 23128226
esv2749825 CNV deletion 23290073
esv2749826 CNV deletion 23290073
esv2749827 CNV deletion 23290073
esv2749828 CNV deletion 23290073
esv2749829 CNV deletion 23290073
esv2749831 CNV deletion 23290073
esv2749832 CNV deletion 23290073
esv2760037 CNV loss 17122850
esv3552626 CNV deletion 23714750
esv3636823 CNV loss 21293372
esv3636824 CNV loss 21293372
esv5119 CNV loss 18987735
nsv1044617 CNV gain 25217958
nsv1151771 CNV deletion 26484159
nsv1151947 CNV deletion 26484159
nsv512401 CNV loss 21212237
nsv827379 CNV loss 20364138
nsv94997 CNV deletion 16902084
nsv951985 CNV deletion 24416366
nsv958022 CNV deletion 24416366

Variation tolerance for PAQR5 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAQR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR5 Gene

Disorders for PAQR5 Gene

Relevant External Links for PAQR5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PAQR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR5 Gene

Publications for PAQR5 Gene

  1. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3 46 64
  2. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 3 4 64
  3. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. (PMID: 12574519) Zhu Y. … Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 64
  4. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. (PMID: 12601167) Zhu Y. … Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PAQR5 Gene

Sources for PAQR5 Gene

Loading form....