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Aliases for PAQR5 Gene

Aliases for PAQR5 Gene

  • Progestin And AdipoQ Receptor Family Member 5 2 3 4
  • Progestin And AdipoQ Receptor Family Member V 2 3 4 5
  • MPR Gamma 3 4
  • MPRG 3 4
  • Membrane Progestin Receptor Gamma 2

External Ids for PAQR5 Gene

Previous GeneCards Identifiers for PAQR5 Gene

  • GC15P067379
  • GC15P069591
  • GC15P046424

Summaries for PAQR5 Gene

GeneCards Summary for PAQR5 Gene

PAQR5 (Progestin And AdipoQ Receptor Family Member 5) is a Protein Coding gene. GO annotations related to this gene include receptor activity and steroid binding. An important paralog of this gene is PAQR6.

UniProtKB/Swiss-Prot for PAQR5 Gene

  • Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR5 Gene

Genomics for PAQR5 Gene

Regulatory Elements for PAQR5 Gene

Enhancers for PAQR5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAQR5 on UCSC Golden Path with GeneCards custom track

Promoters for PAQR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAQR5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAQR5 Gene

Chromosome:
15
Start:
69,298,902 bp from pter
End:
69,407,780 bp from pter
Size:
108,879 bases
Orientation:
Plus strand

Genomic View for PAQR5 Gene

Genes around PAQR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR5 Gene

Proteins for PAQR5 Gene

  • Protein details for PAQR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXK6-MPRG_HUMAN
    Recommended name:
    Membrane progestin receptor gamma
    Protein Accession:
    Q9NXK6
    Secondary Accessions:
    • Q8IXU2

    Protein attributes for PAQR5 Gene

    Size:
    330 amino acids
    Molecular mass:
    38014 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAQR5 Gene

Proteomics data for PAQR5 Gene at MOPED

Post-translational modifications for PAQR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAQR5 Gene

No data available for DME Specific Peptides for PAQR5 Gene

Domains & Families for PAQR5 Gene

Gene Families for PAQR5 Gene

Protein Domains for PAQR5 Gene

Suggested Antigen Peptide Sequences for PAQR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXK6

UniProtKB/Swiss-Prot:

MPRG_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR5: view

Function for PAQR5 Gene

Molecular function for PAQR5 Gene

UniProtKB/Swiss-Prot Function:
Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.

Gene Ontology (GO) - Molecular Function for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IBA --
genes like me logo Genes that share ontologies with PAQR5: view
genes like me logo Genes that share phenotypes with PAQR5: view

Animal Model Products

miRNA for PAQR5 Gene

miRTarBase miRNAs that target PAQR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAQR5 Gene

Localization for PAQR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAQR5 Gene COMPARTMENTS Subcellular localization image for PAQR5 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PAQR5 Gene

Pathways & Interactions for PAQR5 Gene

SuperPathways for PAQR5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048545 response to steroid hormone IBA --
genes like me logo Genes that share ontologies with PAQR5: view

No data available for Pathways by source and SIGNOR curated interactions for PAQR5 Gene

Drugs & Compounds for PAQR5 Gene

No Compound Related Data Available

Transcripts for PAQR5 Gene

Unigene Clusters for PAQR5 Gene

Progestin and adipoQ receptor family member V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for PAQR5 Gene

GeneLoc Exon Structure for
PAQR5
ECgene alternative splicing isoforms for
PAQR5

Expression for PAQR5 Gene

mRNA expression in normal human tissues for PAQR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR5 Gene

This gene is overexpressed in Kidney - Cortex (x10.0), Adrenal Gland (x6.5), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for PAQR5 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAQR5 Gene



SOURCE GeneReport for Unigene cluster for PAQR5 Gene Hs.591096

mRNA Expression by UniProt/SwissProt for PAQR5 Gene

Q9NXK6-MPRG_HUMAN
Tissue specificity: Expressed in the brain, lung, kidney, colon, adrenal and lung.
genes like me logo Genes that share expression patterns with PAQR5: view

Protein tissue co-expression partners for PAQR5 Gene

Primer Products

Orthologs for PAQR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAQR5 35
  • 86.16 (n)
  • 83.33 (a)
PAQR5 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAQR5 35
  • 89.6 (n)
  • 89.7 (a)
PAQR5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paqr5 35
  • 88.38 (n)
  • 91.52 (a)
Paqr5 16
Paqr5 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAQR5 35
  • 99.39 (n)
  • 99.09 (a)
PAQR5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paqr5 35
  • 88.28 (n)
  • 91.52 (a)
oppossum
(Monodelphis domestica)
Mammalia PAQR5 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAQR5 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAQR5 35
  • 66.55 (n)
  • 57.69 (a)
PAQR5 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAQR5 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr5 35
  • 62.8 (n)
  • 57.93 (a)
zebrafish
(Danio rerio)
Actinopterygii paqr5b 35
  • 63.37 (n)
  • 59.88 (a)
zgc56016 35
paqr5a 36
  • 50 (a)
OneToMany
paqr5b 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K11C4.2 36
  • 22 (a)
OneToMany
Species with no ortholog for PAQR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR5 Gene

ENSEMBL:
Gene Tree for PAQR5 (if available)
TreeFam:
Gene Tree for PAQR5 (if available)

Paralogs for PAQR5 Gene

Paralogs for PAQR5 Gene

(2) SIMAP similar genes for PAQR5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PAQR5 Gene

genes like me logo Genes that share paralogs with PAQR5: view

Variants for PAQR5 Gene

Sequence variations from dbSNP and Humsavar for PAQR5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs17853893 - 69,379,902(+) AGGCA(C/T)CCTGT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1655 -- 69,317,157(-) GAAAC(A/G)CCACT intron-variant
rs5012327 -- 69,311,045(+) aaaaa(A/T)aaaaa intron-variant
rs5813535 -- 69,368,062(+) TCTGC(-/T/TT)TTTTT intron-variant
rs5813536 -- 69,368,186(+) TAGCT(-/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR5 Gene

Variant ID Type Subtype PubMed ID
esv2343800 CNV Deletion 18987734
esv2749825 CNV Deletion 23290073
esv2659982 CNV Deletion 23128226
nsv904329 CNV Loss 21882294
esv5119 CNV Deletion 18987735
esv2663165 CNV Deletion 23128226
esv2749826 CNV Deletion 23290073
nsv827379 CNV Loss 20364138
esv2675617 CNV Deletion 23128226
dgv753e1 CNV Complex 17122850
esv2092169 CNV Deletion 18987734
nsv512401 CNV Loss 21212237
nsv94997 CNV Loss 16902084
esv2749827 CNV Deletion 23290073
esv2749828 CNV Deletion 23290073
esv2749829 CNV Deletion 23290073
esv1010893 CNV Deletion 20482838
esv1243241 CNV Deletion 17803354
esv2749831 CNV Deletion 23290073
esv2749832 CNV Deletion 23290073

Variation tolerance for PAQR5 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PAQR5 Gene

Disorders for PAQR5 Gene

Relevant External Links for PAQR5

Genetic Association Database (GAD)
PAQR5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAQR5

No disorders were found for PAQR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR5 Gene

Publications for PAQR5 Gene

  1. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3 48 67
  2. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. (PMID: 12574519) Zhu Y. … Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. (PMID: 21761364) Charles N.J. … Lange C.A. (Horm Cancer 2010) 3

Products for PAQR5 Gene

Sources for PAQR5 Gene

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