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Aliases for PAQR5 Gene

Aliases for PAQR5 Gene

  • Progestin And AdipoQ Receptor Family Member V 2 3 4
  • MPRG 3 4 6
  • Progestin And AdipoQ Receptor Family Member 5 3 4
  • Membrane Progestin Receptor Gamma 2 3
  • MPR Gamma 3 4

External Ids for PAQR5 Gene

Summaries for PAQR5 Gene

GeneCards Summary for PAQR5 Gene

PAQR5 (Progestin And AdipoQ Receptor Family Member V) is a Protein Coding gene. GO annotations related to this gene include steroid binding. An important paralog of this gene is PAQR6.

UniProtKB/Swiss-Prot for PAQR5 Gene

  • Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR5 Gene

Genomics for PAQR5 Gene

Genomic Location for PAQR5 Gene

Start:
69,298,947 bp from pter
End:
69,407,780 bp from pter
Size:
108,834 bases
Orientation:
Plus strand

Genomic View for PAQR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAQR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR5 Gene

Regulatory Elements for PAQR5 Gene

Proteins for PAQR5 Gene

  • Protein details for PAQR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXK6-MPRG_HUMAN
    Recommended name:
    Membrane progestin receptor gamma
    Protein Accession:
    Q9NXK6
    Secondary Accessions:
    • Q8IXU2

    Protein attributes for PAQR5 Gene

    Size:
    330 amino acids
    Molecular mass:
    38014 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAQR5 Gene

Proteomics data for PAQR5 Gene at MOPED

Post-translational modifications for PAQR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAQR5 Gene

No data available for DME Specific Peptides for PAQR5 Gene

Domains for PAQR5 Gene

Protein Domains for PAQR5 Gene

UniProtKB/Swiss-Prot:

MPRG_HUMAN
Family:
  • Belongs to the ADIPOR family.:
    • Q9NXK6
genes like me logo Genes that share domains with PAQR5: view

No data available for Gene Families for PAQR5 Gene

Function for PAQR5 Gene

Molecular function for PAQR5 Gene

UniProtKB/Swiss-Prot Function: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.

Gene Ontology (GO) - Molecular Function for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PAQR5: view

Phenotypes for PAQR5 Gene

genes like me logo Genes that share phenotypes with PAQR5: view

miRNA for PAQR5 Gene

miRTarBase miRNAs that target PAQR5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PAQR5 Gene

Localization for PAQR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAQR5 Gene COMPARTMENTS Subcellular localization image for PAQR5 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR5: view

Pathways for PAQR5 Gene

SuperPathways for PAQR5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0048477 oogenesis IEA --
genes like me logo Genes that share ontologies with PAQR5: view

No data available for Pathways by source for PAQR5 Gene

Transcripts for PAQR5 Gene

Unigene Clusters for PAQR5 Gene

Progestin and adipoQ receptor family member V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for PAQR5 Gene

GeneLoc Exon Structure for
PAQR5
ECgene alternative splicing isoforms for
PAQR5

Expression for PAQR5 Gene

mRNA expression in normal human tissues for PAQR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR5 Gene

This gene is overexpressed in Kidney - Cortex (10.0), Adrenal Gland (6.5), and Colon - Transverse (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAQR5 Gene

SOURCE GeneReport for Unigene cluster for PAQR5 Gene Hs.591096

mRNA Expression by UniProt/SwissProt for PAQR5 Gene

Q9NXK6-MPRG_HUMAN
Tissue specificity: Expressed in the brain, lung, kidney, colon, adrenal and lung.
genes like me logo Genes that share expressions with PAQR5: view

Orthologs for PAQR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR5 36
  • 99.39 (n)
  • 99.09 (a)
PAQR5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAQR5 36
  • 86.16 (n)
  • 83.33 (a)
PAQR5 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAQR5 36
  • 89.6 (n)
  • 89.7 (a)
PAQR5 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paqr5 36
  • 88.38 (n)
  • 91.52 (a)
Paqr5 16
Paqr5 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAQR5 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAQR5 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paqr5 36
  • 88.28 (n)
  • 91.52 (a)
chicken
(Gallus gallus)
Aves PAQR5 36
  • 66.55 (n)
  • 57.69 (a)
PAQR5 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAQR5 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr5 36
  • 62.8 (n)
  • 57.93 (a)
zebrafish
(Danio rerio)
Actinopterygii paqr5a 37
  • 50 (a)
OneToMany
paqr5b 36
  • 63.37 (n)
  • 59.88 (a)
paqr5b 37
  • 56 (a)
OneToMany
zgc56016 36
worm
(Caenorhabditis elegans)
Secernentea K11C4.2 37
  • 22 (a)
OneToMany
Species with no ortholog for PAQR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR5 Gene

ENSEMBL:
Gene Tree for PAQR5 (if available)
TreeFam:
Gene Tree for PAQR5 (if available)

Paralogs for PAQR5 Gene

Paralogs for PAQR5 Gene

Selected SIMAP similar genes for PAQR5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PAQR5 Gene

genes like me logo Genes that share paralogs with PAQR5: view

Variants for PAQR5 Gene

Sequence variations from dbSNP and Humsavar for PAQR5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1655 -- 69,317,157(-) GAAAC(A/G)CCACT intron-variant
rs870334 -- 69,312,795(+) ATTGC(A/T)GTACT upstream-variant-2KB, intron-variant
rs870335 -- 69,312,804(+) CTGAA(G/T)CCTGA upstream-variant-2KB, intron-variant
rs870336 -- 69,312,710(+) AGAAA(A/T)AAAAA upstream-variant-2KB, intron-variant
rs874706 -- 69,369,039(+) gtttt(A/G)gcatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR5 Gene

Variant ID Type Subtype PubMed ID
esv2343800 CNV Deletion 18987734
esv2749825 CNV Deletion 23290073
esv2659982 CNV Deletion 23128226
nsv904329 CNV Loss 21882294
esv5119 CNV Deletion 18987735
esv2663165 CNV Deletion 23128226
esv2749826 CNV Deletion 23290073
nsv827379 CNV Loss 20364138
esv2675617 CNV Deletion 23128226
dgv753e1 CNV Complex 17122850
esv2092169 CNV Deletion 18987734
nsv512401 CNV Loss 21212237
nsv94997 CNV Loss 16902084
esv2749827 CNV Deletion 23290073
esv2749828 CNV Deletion 23290073
esv2749829 CNV Deletion 23290073
esv1010893 CNV Deletion 20482838
esv1243241 CNV Deletion 17803354
esv2749831 CNV Deletion 23290073
esv2749832 CNV Deletion 23290073

Relevant External Links for PAQR5 Gene

HapMap Linkage Disequilibrium report
PAQR5

Disorders for PAQR5 Gene

Relevant External Links for PAQR5

Genetic Association Database (GAD)
PAQR5
genes like me logo Genes that share disorders with PAQR5: view

No data available for UniProtKB/Swiss-Prot for PAQR5 Gene

Publications for PAQR5 Gene

  1. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3 49
  2. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. (PMID: 12574519) Zhu Y. … Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3
  3. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. (PMID: 12601167) Zhu Y. … Thomas P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 3 4
  5. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. (PMID: 18603275) Smith J.L. … Lyons T.J. (Steroids 2008) 3

Products for PAQR5 Gene

Sources for PAQR5 Gene

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