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GIFtS

PAQR3 Gene

protein-coding   GIFtS: 46
GCID: GC04M079808

progestin and adipoQ receptor family member III
 Explore 1 disease affiliated with
PAQR3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PAQR3    

Aliases
for PAQR3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Progestin And AdipoQ Receptor Family Member III1 2 3
RKTG2 3
Raf Kinase Trapping To Golgi2 3
Progestin And AdipoQ Receptor Family Member 32

External Ids:    HGNC: 301301   Entrez Gene: 1525592   Ensembl: ENSG000001632917   OMIM: 6145775   UniProtKB: Q6TCH73   

Export aliases for PAQR3 gene to outside databases

Previous GC identifers: GC04M080266 GC04M080297 GC04M080165 GC04M080027 GC04M075584


Summaries
for PAQR3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PAQR3_HUMAN, Q6TCH7
Function: Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi




Genomic Views
for PAQR3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PAQR3 gene promoter:
         COUP-TF1   ER-alpha   RP58   Tal-1   COUP   HNF-4alpha2   HNF-3beta   E47   HNF-4alpha1   COUP-TF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PAQR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAQR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

PAQR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAQR3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M079808:  view genomic region     (about GC identifiers)

Start:
 79,808,281 bp from pter      End:
 79,860,592 bp from pter
Size:
 52,312 bases      Orientation:
 minus strand

Proteins
for PAQR3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PAQR3_HUMAN, Q6TCH7 (See protein sequence)
Recommended Name: Progestin and adipoQ receptor family member 3  
Size: 311 amino acids; 36217 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAG51571.1; Type=Erroneous initiation;
Secondary accessions: A8K5B7 B3KP59 Q6PIQ1 Q86X05 Q8NCP9
Alternative splicing: 4 isoforms:  Q6TCH7-1   Q6TCH7-2   Q6TCH7-3   Q6TCH7-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for PAQR3: NX_Q6TCH7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6TCH7

    • PAQR3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001035292.1  
    ENSEMBL proteins: 
     ENSP00000426875   ENSP00000344203   ENSP00000425080   ENSP00000421981   ENSP00000378959  
     ENSP00000422357   ENSP00000420848   ENSP00000370019   ENSP00000295462  

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    Novus Biologicals PAQR3 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PAQR3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral to membrane IEA--


    PAQR3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PAQR3

    Protein Domains /
    Families
    for PAQR3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PAQR3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004254 HlyIII-related

    Graphical View of Domain Structure for InterPro Entry Q6TCH7

    ProtoNet protein and cluster: Q6TCH7

    1 Blocks protein family: IPB004254 Hly-III related proteins

    UniProtKB/Swiss-Prot: PAQR3_HUMAN, Q6TCH7
    Similarity: Belongs to the ADIPOR family


    Function
    for PAQR3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PAQR3_HUMAN, Q6TCH7
    Function: Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi

    miRNA
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    hsa-miR-142-5p hsa-miR-607 hsa-miR-562 hsa-miR-199a-3p hsa-miR-15a hsa-miR-29a hsa-miR-374a hsa-miR-10b*
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    Inhib. RNA
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    OriGene shRNA RFP: PAQR3
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for PAQR3

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    PAQR3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PAQR3:
     Decreased cilium length  Decreased cilium length after  

    Animal Models:
         Mouse knock-out Paqr3tm1Ychn for PAQR3
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Paqr3):
     cellular  homeostasis/metabolism  integument  tumorigenesis 

    PAQR3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PAQR3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PAQR3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PAQR3 (ENSP000003700194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAF1ENSP000002518494STRING: ENSP00000251849
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Drugs & Compounds
    for PAQR3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PAQR3
    Search CenterWatch for drugs/clinical trials and news about PAQR3 

    Transcripts
    for PAQR3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PAQR3 gene (2 alternative transcripts): 
    NM_177453.2  NM_001040202.1  

    Unigene Cluster for PAQR3:

    Progestin and adipoQ receptor family member III
    Hs.657312  [show with all ESTs]
    Unigene Representative Sequence: NM_001040202
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512760 ENST00000342820(uc003hlm.3 uc003hln.3) ENST00000511594
    ENST00000512733(uc003hlp.1 uc003hlq.1) ENST00000515541 ENST00000503343
    ENST00000395594 ENST00000515853 ENST00000505715 ENST00000512299 ENST00000505735
    ENST00000508599 ENST00000380645 ENST00000295462

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PAQR3
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAQR3
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PAQR3 (see all 43):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-562 hsa-miR-199a-3p hsa-miR-15a hsa-miR-29a hsa-miR-374a hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAQR3 (see all 7)
    OriGene shRNA RFP: PAQR3
    Browse OriGene siRNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK055774.1 AK126273.1 AK291232.1 AL080110.1 AY424281.1 BX648346.1 

    12 DOTS entries:

    DT.101982068  DT.101955948  DT.121256326  DT.86836949  DT.212016  DT.40127776  DT.121256234  DT.95280119 
    DT.99997657  DT.310672  DT.40121851  DT.75183646 

    24/99 AceView cDNA sequences (see all 99):

    AL080110 AW178412 BX105202 AI123291 CR604581 AA431680 CD108809 AY424281 
    CR606971 AW954260 AK055774 AI522291 AI024933 BM984085 BC047510 NM_177453 
    AI968693 AV728911 CB960485 BQ435613 BM546935 AL522824 BC031256 BX500759 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PAQR3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                      -     -                                   -                       -     -     -                 -                     
    SP2:                                -     -     -                                   -     -     -           -     -     -                 -           -         
    SP3:                                      -     -                                   -     -                                                                     
    SP4:                                      -     -                                   -     -     -                                                               
    SP5:                                -     -     -                                   -     -     -                                                               


    ECgene alternative splicing isoforms for PAQR3

    Expression
    for PAQR3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PAQR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAAATATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PAQR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PAQR3

    SOURCE GeneReport for Unigene cluster: Hs.657312

    UniProtKB/Swiss-Prot: PAQR3_HUMAN, Q6TCH7
    Tissue specificity: Widely expressed in a range of tissues

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    In Situ
    Assay Products:     
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    Orthologs
    for PAQR3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PAQR3 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Paqr31 , 5 progestin and adipoQ receptor family member III1, 5 90.89(n)1
    97.75(a)1    		   5 (47.29 cM)5
    2314741  NM_198422.21  NP_940814.11 
     970823295 
    chicken
    (Gallus gallus)    		 Aves PAQR31 progestin and adipoQ receptor family member III 80.56(n)
    87.62(a)    		   770386  XM_001233720.2  XP_001233721.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PAQR36
    		 --
    		 92(a)
    		 1 ↔ 1
    		 5(145400541-145409170)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.154542 Transcribed sequence with weak similarity to protein more 77.84(n)    BX714333.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc730982 hypothetical protein MGC73098 75.04(n)   393683  BC059466.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG75306
    		 --
    		 28(a)
    		 1 ↔ 1
    		 3R(10550482-10557231)
    worm
    (Caenorhabditis elegans)    		 Secernentea paqr-36
    		 --
    		 29(a)
    		 1 ↔ 1
    		 IV(14379925-14383654)
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_AAL153C1 AAL153Cp 39.72(n)
    28.51(a)    		   4618444  NM_207742.1  NP_982389.1 


    ENSEMBL Gene Tree for PAQR3 (if available)
    TreeFam Gene Tree for PAQR3 (if available) 

    Paralogs
    for PAQR3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PAQR3 gene
    ADIPOR12  PAQR92  PAQR82  PAQR72  PAQR42  PAQR62  ADIPOR22  PAQR52  
    2 SIMAP similar genes for PAQR3 using alignment to 3 protein entries:     PAQR3_HUMAN (see all proteins):
    ADIPOR2    ADIPOR1

    PAQR3 for paralogs           About GeneDecksing



    Genomic Variants
    for PAQR3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAQR3
    DNA2.0 Custom Variant and Variant Library Synthesis for PAQR3

    Disorders / Diseases
    for PAQR3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PAQR3 for disorders           About GeneDecksing

    OMIM gene information: 614577    OMIM disorders: --

    1 disease for PAQR3:    About MalaCards
    melanoma


    Export disorders for PAQR3 gene to outside databases

    Publications
    for PAQR3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PAQR3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with PAQR3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PubMed id 16044242)1, 2, 3 Tang Y.T....Funk W.D. (2005)
    2. Characterization of the topology and functional domains of RKTG. (PubMed id 18547165)1, 2 Luo X.... Chen Y. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers. (PubMed id 22828136)1 Wang X....Chen Y. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Regulation of G-protein signaling by RKTG via sequest ration of the G betagamma subunit to the Golgi apparatus. (PubMed id 19884349)1 Jiang Y....Chen Y. (2010)
    8. Adiponectin identified as an agonist for PAQR3/RKTG u sing a yeast-based assay system. (PubMed id 19519172)1 Garitaonandia I....Lyons T.J. (2009)
    9. RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells. (PubMed id 18515281)1 Fan F....Chen Y. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for PAQR3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PAQR3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 152559 HGNC: 30130 AceView: PAQR3 Ensembl:ENSG00000163291 euGenes: HUgn152559
    ECgene: PAQR3 H-InvDB: PAQR3

    Other Databases showing PAQR3 gene

    (According to HUGE)
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    Specialized Databases showing PAQR3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PAQR3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PAQR3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PAQR3 gene:
    Search GeneIP for patents involving PAQR3

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