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Aliases for PAQR3 Gene

Aliases for PAQR3 Gene

  • Progestin And AdipoQ Receptor Family Member 3 2 3
  • Progestin And AdipoQ Receptor Family Member III 2 3 4 5
  • Raf Kinase Trapping To Golgi 3 4
  • RKTG 3 4

External Ids for PAQR3 Gene

Previous GeneCards Identifiers for PAQR3 Gene

  • GC04M080266
  • GC04M080297
  • GC04M080165
  • GC04M080027
  • GC04M079808
  • GC04M075584

Summaries for PAQR3 Gene

GeneCards Summary for PAQR3 Gene

PAQR3 (Progestin And AdipoQ Receptor Family Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include receptor activity. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot for PAQR3 Gene

  • Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR3 Gene

Genomics for PAQR3 Gene

Regulatory Elements for PAQR3 Gene

Promoters for PAQR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAQR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAQR3 Gene

Chromosome:
4
Start:
78,887,127 bp from pter
End:
78,939,438 bp from pter
Size:
52,312 bases
Orientation:
Minus strand

Genomic View for PAQR3 Gene

Genes around PAQR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR3 Gene

Proteins for PAQR3 Gene

  • Protein details for PAQR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TCH7-PAQR3_HUMAN
    Recommended name:
    Progestin and adipoQ receptor family member 3
    Protein Accession:
    Q6TCH7
    Secondary Accessions:
    • A8K5B7
    • B3KP59
    • Q6PIQ1
    • Q86X05
    • Q8NCP9

    Protein attributes for PAQR3 Gene

    Size:
    311 amino acids
    Molecular mass:
    36217 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG51571.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PAQR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAQR3 Gene

Proteomics data for PAQR3 Gene at MOPED

Post-translational modifications for PAQR3 Gene

  • Ubiquitination at Lys 7
  • Modification sites at PhosphoSitePlus

Other Protein References for PAQR3 Gene

No data available for DME Specific Peptides for PAQR3 Gene

Domains & Families for PAQR3 Gene

Gene Families for PAQR3 Gene

Protein Domains for PAQR3 Gene

Suggested Antigen Peptide Sequences for PAQR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6TCH7

UniProtKB/Swiss-Prot:

PAQR3_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR3: view

Function for PAQR3 Gene

Molecular function for PAQR3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
genes like me logo Genes that share phenotypes with PAQR3: view

Animal Models for PAQR3 Gene

MGI Knock Outs for PAQR3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAQR3 Gene

Localization for PAQR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAQR3 Gene COMPARTMENTS Subcellular localization image for PAQR3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for PAQR3 Gene

Pathways & Interactions for PAQR3 Gene

SuperPathways for PAQR3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 Negative regulation of MAPK pathway
genes like me logo Genes that share pathways with PAQR3: view

Pathways by source for PAQR3 Gene

Interacting Proteins for PAQR3 Gene

Gene Ontology (GO) - Biological Process for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0001933 negative regulation of protein phosphorylation IDA 17724343
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007265 Ras protein signal transduction TAS --
genes like me logo Genes that share ontologies with PAQR3: view

No data available for SIGNOR curated interactions for PAQR3 Gene

Drugs & Compounds for PAQR3 Gene

No Compound Related Data Available

Transcripts for PAQR3 Gene

Unigene Clusters for PAQR3 Gene

Progestin and adipoQ receptor family member III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - -
SP8:
SP9:

Relevant External Links for PAQR3 Gene

GeneLoc Exon Structure for
PAQR3
ECgene alternative splicing isoforms for
PAQR3

Expression for PAQR3 Gene

mRNA expression in normal human tissues for PAQR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR3 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for PAQR3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAQR3 Gene



SOURCE GeneReport for Unigene cluster for PAQR3 Gene Hs.657312

mRNA Expression by UniProt/SwissProt for PAQR3 Gene

Q6TCH7-PAQR3_HUMAN
Tissue specificity: Widely expressed in a range of tissues.
genes like me logo Genes that share expression patterns with PAQR3: view

Protein tissue co-expression partners for PAQR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PAQR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAQR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR3 35
  • 99.68 (n)
  • 99.68 (a)
PAQR3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAQR3 36
  • 99 (a)
OneToOne
PAQR3 35
  • 93.68 (n)
  • 99.04 (a)
dog
(Canis familiaris)
Mammalia PAQR3 35
  • 94.79 (n)
  • 99.35 (a)
PAQR3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paqr3 16
Paqr3 36
  • 98 (a)
OneToOne
Paqr3 35
  • 90.89 (n)
  • 97.75 (a)
oppossum
(Monodelphis domestica)
Mammalia PAQR3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAQR3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paqr3 35
  • 87.78 (n)
  • 97.43 (a)
chicken
(Gallus gallus)
Aves PAQR3 36
  • 87 (a)
OneToOne
PAQR3 35
  • 80.56 (n)
  • 87.62 (a)
lizard
(Anolis carolinensis)
Reptilia PAQR3 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr3 35
  • 78.39 (n)
  • 90.23 (a)
Str.15454 35
zebrafish
(Danio rerio)
Actinopterygii paqr3a 36
  • 76 (a)
OneToMany
paqr3b 36
  • 77 (a)
OneToMany
paqr3a 35
  • 71.12 (n)
  • 76.55 (a)
zgc73098 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000144 35
  • 48.02 (n)
  • 40.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7530 36
  • 32 (a)
OneToOne
CG7530 35
  • 48.57 (n)
  • 39.41 (a)
worm
(Caenorhabditis elegans)
Secernentea paqr-3 35
  • 47.28 (n)
  • 34.81 (a)
paqr-3 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH1 36
  • 23 (a)
ManyToMany
IZH2 36
  • 21 (a)
ManyToMany
Species with no ortholog for PAQR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR3 Gene

ENSEMBL:
Gene Tree for PAQR3 (if available)
TreeFam:
Gene Tree for PAQR3 (if available)

Paralogs for PAQR3 Gene

Paralogs for PAQR3 Gene

(2) SIMAP similar genes for PAQR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PAQR3: view

Variants for PAQR3 Gene

Sequence variations from dbSNP and Humsavar for PAQR3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1275046 -- 78,917,354(+) CCTTG(C/G)TGGCT intron-variant
rs1275047 -- 78,917,608(+) AGCTG(A/C)TTCTT intron-variant, downstream-variant-500B
rs2127781 -- 78,921,795(-) TTCAT(A/G)TATAA intron-variant
rs1871706 -- 78,928,143(-) CTAAA(C/T)GTCAA intron-variant
rs3063972 -- 78,925,361(+) TTTTC(-/ATTTTC)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR3 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
nsv879504 CNV Loss 21882294
nsv829979 CNV Gain 17160897

Variation tolerance for PAQR3 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAQR3 Gene

HapMap Linkage Disequilibrium report
PAQR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR3 Gene

Disorders for PAQR3 Gene

Relevant External Links for PAQR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAQR3

No disorders were found for PAQR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR3 Gene

Publications for PAQR3 Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 2 3 4 67
  2. PAQR3 modulates H3K4 trimethylation by spatial modulation of the regulatory subunits of COMPASS-like complexes in mammalian cells. (PMID: 25706881) Liu C. … Chen Y. (Biochem. J. 2015) 3
  3. The tumor suppressor role of PAQR3 in osteosarcoma. (PMID: 25510670) Ma Z. … Liu J. (Tumour Biol. 2015) 3
  4. MicroRNA-137 upregulation increases bladder cancer cell proliferation and invasion by targeting PAQR3. (PMID: 25330156) Xiu Y. … Wu Q. (PLoS ONE 2014) 3
  5. Identification of PAQR3 as a new candidate tumor suppressor in hepatocellular carcinoma. (PMID: 25310770) Wu H.G. … Li P.D. (Oncol. Rep. 2014) 3

Products for PAQR3 Gene

Sources for PAQR3 Gene

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