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Aliases for PAQR3 Gene

Aliases for PAQR3 Gene

  • Progestin And AdipoQ Receptor Family Member 3 2 3
  • Progestin And AdipoQ Receptor Family Member III 2 3 4 5
  • Raf Kinase Trapping To Golgi 3 4
  • RKTG 3 4

External Ids for PAQR3 Gene

Previous GeneCards Identifiers for PAQR3 Gene

  • GC04M080266
  • GC04M080297
  • GC04M080165
  • GC04M080027
  • GC04M079808
  • GC04M075584

Summaries for PAQR3 Gene

GeneCards Summary for PAQR3 Gene

PAQR3 (Progestin And AdipoQ Receptor Family Member 3) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include receptor activity. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot for PAQR3 Gene

  • Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR3 Gene

Genomics for PAQR3 Gene

Regulatory Elements for PAQR3 Gene

Enhancers for PAQR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAQR3 on UCSC Golden Path with GeneCards custom track

Promoters for PAQR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAQR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAQR3 Gene

78,887,127 bp from pter
78,939,438 bp from pter
52,312 bases
Minus strand

Genomic View for PAQR3 Gene

Genes around PAQR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR3 Gene

Proteins for PAQR3 Gene

  • Protein details for PAQR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Progestin and adipoQ receptor family member 3
    Protein Accession:
    Secondary Accessions:
    • A8K5B7
    • B3KP59
    • Q6PIQ1
    • Q86X05
    • Q8NCP9

    Protein attributes for PAQR3 Gene

    311 amino acids
    Molecular mass:
    36217 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG51571.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PAQR3 Gene


neXtProt entry for PAQR3 Gene

Proteomics data for PAQR3 Gene at MOPED

Post-translational modifications for PAQR3 Gene

  • Ubiquitination at Lys 7
  • Modification sites at PhosphoSitePlus

Other Protein References for PAQR3 Gene

No data available for DME Specific Peptides for PAQR3 Gene

Domains & Families for PAQR3 Gene

Gene Families for PAQR3 Gene

Protein Domains for PAQR3 Gene

Suggested Antigen Peptide Sequences for PAQR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ADIPOR family.
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR3: view

Function for PAQR3 Gene

Molecular function for PAQR3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
genes like me logo Genes that share phenotypes with PAQR3: view

Animal Models for PAQR3 Gene

MGI Knock Outs for PAQR3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAQR3 Gene

Localization for PAQR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PAQR3 Gene COMPARTMENTS Subcellular localization image for PAQR3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for PAQR3 Gene

Pathways & Interactions for PAQR3 Gene

SuperPathways for PAQR3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by GPCR
5 Negative regulation of MAPK pathway
genes like me logo Genes that share pathways with PAQR3: view

Pathways by source for PAQR3 Gene

Interacting Proteins for PAQR3 Gene

Gene Ontology (GO) - Biological Process for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0001933 negative regulation of protein phosphorylation IDA 17724343
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007265 Ras protein signal transduction TAS --
genes like me logo Genes that share ontologies with PAQR3: view

No data available for SIGNOR curated interactions for PAQR3 Gene

Drugs & Compounds for PAQR3 Gene

No Compound Related Data Available

Transcripts for PAQR3 Gene

Unigene Clusters for PAQR3 Gene

Progestin and adipoQ receptor family member III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - -

Relevant External Links for PAQR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAQR3 Gene

mRNA expression in normal human tissues for PAQR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR3 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for PAQR3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAQR3 Gene

SOURCE GeneReport for Unigene cluster for PAQR3 Gene Hs.657312

mRNA Expression by UniProt/SwissProt for PAQR3 Gene

Tissue specificity: Widely expressed in a range of tissues.
genes like me logo Genes that share expression patterns with PAQR3: view

Protein tissue co-expression partners for PAQR3 Gene

- Elite partner

Primer Products

Orthologs for PAQR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAQR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PAQR3 35
  • 93.68 (n)
  • 99.04 (a)
PAQR3 36
  • 99 (a)
(Canis familiaris)
Mammalia PAQR3 35
  • 94.79 (n)
  • 99.35 (a)
PAQR3 36
  • 99 (a)
(Mus musculus)
Mammalia Paqr3 35
  • 90.89 (n)
  • 97.75 (a)
Paqr3 16
Paqr3 36
  • 98 (a)
(Pan troglodytes)
Mammalia PAQR3 35
  • 99.68 (n)
  • 99.68 (a)
PAQR3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Paqr3 35
  • 87.78 (n)
  • 97.43 (a)
(Monodelphis domestica)
Mammalia PAQR3 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia PAQR3 36
  • 93 (a)
(Gallus gallus)
Aves PAQR3 35
  • 80.56 (n)
  • 87.62 (a)
PAQR3 36
  • 87 (a)
(Anolis carolinensis)
Reptilia PAQR3 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr3 35
  • 78.39 (n)
  • 90.23 (a)
Str.15454 35
(Danio rerio)
Actinopterygii paqr3a 35
  • 71.12 (n)
  • 76.55 (a)
zgc73098 35
paqr3a 36
  • 76 (a)
paqr3b 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000144 35
  • 48.02 (n)
  • 40.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7530 35
  • 48.57 (n)
  • 39.41 (a)
CG7530 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea paqr-3 35
  • 47.28 (n)
  • 34.81 (a)
paqr-3 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH1 36
  • 23 (a)
IZH2 36
  • 21 (a)
Species with no ortholog for PAQR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR3 Gene

Gene Tree for PAQR3 (if available)
Gene Tree for PAQR3 (if available)

Paralogs for PAQR3 Gene

Paralogs for PAQR3 Gene

(2) SIMAP similar genes for PAQR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PAQR3: view

Variants for PAQR3 Gene

Sequence variations from dbSNP and Humsavar for PAQR3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1275046 -- 78,917,354(+) CCTTG(C/G)TGGCT intron-variant
rs1275047 -- 78,917,608(+) AGCTG(A/C)TTCTT intron-variant, downstream-variant-500B
rs1299129 -- 78,917,522(+) AGGAC(C/T)GTATT intron-variant, downstream-variant-500B
rs1480718 -- 78,925,281(-) AATTT(C/T)TAGAT intron-variant
rs1564458 -- 78,919,802(-) TTAGC(C/T)ACCTA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PAQR3 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
nsv879504 CNV Loss 21882294
nsv829979 CNV Gain 17160897

Variation tolerance for PAQR3 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PAQR3 Gene

Disorders for PAQR3 Gene

Relevant External Links for PAQR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PAQR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR3 Gene

Publications for PAQR3 Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 2 3 4 67
  2. The tumor suppressor role of PAQR3 in osteosarcoma. (PMID: 25510670) Ma Z. … Liu J. (Tumour Biol. 2015) 3
  3. PAQR3 modulates H3K4 trimethylation by spatial modulation of the regulatory subunits of COMPASS-like complexes in mammalian cells. (PMID: 25706881) Liu C. … Chen Y. (Biochem. J. 2015) 3
  4. PAQR3 expression is downregulated in human breast cancers and correlated with HER2 expression. (PMID: 25900239) Li Z. … Chen Y. (Oncotarget 2015) 3
  5. DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells. (PMID: 26205499) Qiao S. … Chen Y. (Biochem. J. 2015) 3

Products for PAQR3 Gene

Sources for PAQR3 Gene