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Aliases for PAQR3 Gene

Aliases for PAQR3 Gene

  • Progestin And AdipoQ Receptor Family Member 3 2 3 5
  • Progestin And AdipoQ Receptor Family Member III 2 3 4
  • Raf Kinase Trapping To Golgi 3 4
  • RKTG 3 4

External Ids for PAQR3 Gene

Previous GeneCards Identifiers for PAQR3 Gene

  • GC04M080266
  • GC04M080297
  • GC04M080165
  • GC04M080027
  • GC04M079808
  • GC04M075584

Summaries for PAQR3 Gene

Entrez Gene Summary for PAQR3 Gene

  • This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for PAQR3 Gene

PAQR3 (Progestin And AdipoQ Receptor Family Member 3) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. GO annotations related to this gene include receptor activity. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot for PAQR3 Gene

  • Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR3 Gene

Genomics for PAQR3 Gene

Regulatory Elements for PAQR3 Gene

Enhancers for PAQR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G078862 1.5 Ensembl ENCODE dbSUPER 10.6 +75.3 75279 4.1 HNRNPUL1 FOXA2 ARNT ARID4B YY1 ZNF143 MXD4 REST MIER2 PPARG ENSG00000200998 PAQR3 BMP2K RN7SL127P GC04M078827
GH04G078774 1.4 ENCODE dbSUPER 7.4 +162.1 162075 6.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 PAQR3 BMP2K LOC105377299
GH04G078938 1 ENCODE 8.5 +0.1 105 2.1 ATF1 ARNT CREB3L1 ARID4B SIN3A GLI4 ZNF143 KLF7 KLF13 KDM4B PAQR3 LINC01088 GC04P078913
GH04G078937 0.7 FANTOM5 9.4 +1.4 1434 0.2 JUN ATF2 FOSL1 JUND ZNF366 ATF3 CREB1 ZBTB33 WT1 PAQR3 GC04P078913
GH04G078923 0.6 ENCODE 7.9 +15.7 15693 1.0 CTCF IRF2 HNF4G HNF4A IRF1 PRDM1 RAD21 PAQR3 GC04P078913
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAQR3 on UCSC Golden Path with GeneCards custom track

Promoters for PAQR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169768 138 1801 ATF1 ARNT CREB3L1 ARID4B SIN3A GLI4 ZNF143 KLF13 KDM4B SP5

Genomic Location for PAQR3 Gene

Chromosome:
4
Start:
78,887,127 bp from pter
End:
78,939,438 bp from pter
Size:
52,312 bases
Orientation:
Minus strand

Genomic View for PAQR3 Gene

Genes around PAQR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR3 Gene

Proteins for PAQR3 Gene

  • Protein details for PAQR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TCH7-PAQR3_HUMAN
    Recommended name:
    Progestin and adipoQ receptor family member 3
    Protein Accession:
    Q6TCH7
    Secondary Accessions:
    • A8K5B7
    • B3KP59
    • Q6PIQ1
    • Q86X05
    • Q8NCP9

    Protein attributes for PAQR3 Gene

    Size:
    311 amino acids
    Molecular mass:
    36217 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG51571.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PAQR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAQR3 Gene

Post-translational modifications for PAQR3 Gene

  • Ubiquitination at posLast=77
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAQR3 Gene

Domains & Families for PAQR3 Gene

Gene Families for PAQR3 Gene

Protein Domains for PAQR3 Gene

Suggested Antigen Peptide Sequences for PAQR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6TCH7

UniProtKB/Swiss-Prot:

PAQR3_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR3: view

Function for PAQR3 Gene

Molecular function for PAQR3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

Gene Ontology (GO) - Molecular Function for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with PAQR3: view
genes like me logo Genes that share phenotypes with PAQR3: view

Animal Models for PAQR3 Gene

MGI Knock Outs for PAQR3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAQR3 Gene

Localization for PAQR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 17724343
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR3: view

Pathways & Interactions for PAQR3 Gene

SuperPathways for PAQR3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with PAQR3: view

Pathways by source for PAQR3 Gene

Gene Ontology (GO) - Biological Process for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001933 negative regulation of protein phosphorylation IDA 17724343
GO:0010977 negative regulation of neuron projection development IDA 17724343
GO:0033137 negative regulation of peptidyl-serine phosphorylation IDA 17724343
GO:0034067 protein localization to Golgi apparatus IPI 17724343
genes like me logo Genes that share ontologies with PAQR3: view

No data available for SIGNOR curated interactions for PAQR3 Gene

Drugs & Compounds for PAQR3 Gene

No Compound Related Data Available

Transcripts for PAQR3 Gene

Unigene Clusters for PAQR3 Gene

Progestin and adipoQ receptor family member III:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - -
SP8:
SP9:

Relevant External Links for PAQR3 Gene

GeneLoc Exon Structure for
PAQR3
ECgene alternative splicing isoforms for
PAQR3

Expression for PAQR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAQR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR3 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for PAQR3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAQR3 Gene



Protein tissue co-expression partners for PAQR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PAQR3 Gene:

PAQR3

SOURCE GeneReport for Unigene cluster for PAQR3 Gene:

Hs.657312

mRNA Expression by UniProt/SwissProt for PAQR3 Gene:

Q6TCH7-PAQR3_HUMAN
Tissue specificity: Widely expressed in a range of tissues.

Evidence on tissue expression from TISSUES for PAQR3 Gene

  • Kidney(4.2)
  • Nervous system(4)
  • Lung(3.8)
  • Liver(2.9)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with PAQR3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAQR3 Gene

Orthologs for PAQR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAQR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR3 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia PAQR3 34 35
  • 94.79 (n)
cow
(Bos Taurus)
Mammalia PAQR3 34 35
  • 93.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PAQR3 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paqr3 34 16 35
  • 90.89 (n)
rat
(Rattus norvegicus)
Mammalia Paqr3 34
  • 87.78 (n)
oppossum
(Monodelphis domestica)
Mammalia PAQR3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAQR3 34 35
  • 80.56 (n)
lizard
(Anolis carolinensis)
Reptilia PAQR3 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr3 34
  • 78.39 (n)
Str.15454 34
zebrafish
(Danio rerio)
Actinopterygii paqr3b 35
  • 77 (a)
OneToMany
paqr3a 34 35
  • 71.12 (n)
zgc73098 34
fruit fly
(Drosophila melanogaster)
Insecta CG7530 34 35
  • 48.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000144 34
  • 48.02 (n)
worm
(Caenorhabditis elegans)
Secernentea paqr-3 34 35
  • 47.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH1 35
  • 23 (a)
ManyToMany
IZH2 35
  • 21 (a)
ManyToMany
Species where no ortholog for PAQR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR3 Gene

ENSEMBL:
Gene Tree for PAQR3 (if available)
TreeFam:
Gene Tree for PAQR3 (if available)

Paralogs for PAQR3 Gene

Paralogs for PAQR3 Gene

(2) SIMAP similar genes for PAQR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PAQR3: view

Variants for PAQR3 Gene

Sequence variations from dbSNP and Humsavar for PAQR3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs386352343 Uncertain significance 78,926,573(-) GATTC(C/G)TACTC nc-transcript-variant, reference, missense
rs138262352 Benign 78,912,028(+) CTAAA(C/G/T)AGTAG intron-variant, reference, missense, stop-gained
rs1000043750 -- 78,937,253(+) GTTAG(A/G/T)GGGAA intron-variant
rs1000146354 -- 78,919,053(+) CTATA(C/T)TAGCA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000179194 -- 78,902,216(+) TAGTT(C/T)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR3 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV deletion 23290073
nsv1006026 CNV loss 25217958
nsv829979 CNV gain 17160897

Variation tolerance for PAQR3 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAQR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAQR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR3 Gene

Disorders for PAQR3 Gene

Relevant External Links for PAQR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAQR3

No disorders were found for PAQR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR3 Gene

Publications for PAQR3 Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 2 3 4 64
  2. Characterization of the topology and functional domains of RKTG. (PMID: 18547165) Luo X. … Chen Y. (Biochem. J. 2008) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response. (PMID: 27212020) Zhang Y. … Chen Y. (Free Radic. Biol. Med. 2016) 3 64

Products for PAQR3 Gene

Sources for PAQR3 Gene

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