Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PAQR3 Gene

Aliases for PAQR3 Gene

  • Progestin And AdipoQ Receptor Family Member III 2 3 4
  • RKTG 3 4 6
  • Raf Kinase Trapping To Golgi 3 4
  • Progestin And AdipoQ Receptor Family Member 3 3

External Ids for PAQR3 Gene

Previous GeneCards Identifiers for PAQR3 Gene

  • GC04M080266
  • GC04M080297
  • GC04M080165
  • GC04M080027
  • GC04M079808
  • GC04M075584

Summaries for PAQR3 Gene

GeneCards Summary for PAQR3 Gene

PAQR3 (Progestin And AdipoQ Receptor Family Member III) is a Protein Coding gene. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot for PAQR3 Gene

  • Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR3 Gene

Genomics for PAQR3 Gene

Regulatory Elements for PAQR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PAQR3 Gene

Start:
78,887,127 bp from pter
End:
78,939,438 bp from pter
Size:
52,312 bases
Orientation:
Minus strand

Genomic View for PAQR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAQR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR3 Gene

Proteins for PAQR3 Gene

  • Protein details for PAQR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TCH7-PAQR3_HUMAN
    Recommended name:
    Progestin and adipoQ receptor family member 3
    Protein Accession:
    Q6TCH7
    Secondary Accessions:
    • A8K5B7
    • B3KP59
    • Q6PIQ1
    • Q86X05
    • Q8NCP9

    Protein attributes for PAQR3 Gene

    Size:
    311 amino acids
    Molecular mass:
    36217 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG51571.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PAQR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAQR3 Gene

Proteomics data for PAQR3 Gene at MOPED

Post-translational modifications for PAQR3 Gene

  • Ubiquitination at Lys7
  • Modification sites at PhosphoSitePlus

Other Protein References for PAQR3 Gene

No data available for DME Specific Peptides for PAQR3 Gene

Domains for PAQR3 Gene

Protein Domains for PAQR3 Gene

Suggested Antigen Peptide Sequences for PAQR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6TCH7

UniProtKB/Swiss-Prot:

PAQR3_HUMAN :
  • Q6TCH7
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR3: view

No data available for Gene Families for PAQR3 Gene

Function for PAQR3 Gene

Molecular function for PAQR3 Gene

UniProtKB/Swiss-Prot Function: Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

Gene Ontology (GO) - Molecular Function for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with PAQR3: view
genes like me logo Genes that share phenotypes with PAQR3: view

Animal Models for PAQR3 Gene

MGI Knock Outs for PAQR3:

Animal Model Products

CRISPR Products

miRNA for PAQR3 Gene

miRTarBase miRNAs that target PAQR3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAQR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PAQR3 Gene

Localization for PAQR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAQR3 Gene COMPARTMENTS Subcellular localization image for PAQR3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA 17724343
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR3: view

Pathways for PAQR3 Gene

SuperPathways for PAQR3 Gene

No Data Available

Interacting Proteins for PAQR3 Gene

Gene Ontology (GO) - Biological Process for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IDA 17724343
GO:0010977 negative regulation of neuron projection development IDA 17724343
GO:0033137 negative regulation of peptidyl-serine phosphorylation IDA 17724343
GO:0034067 protein localization to Golgi apparatus IPI 17724343
GO:0043407 negative regulation of MAP kinase activity IDA 17724343
genes like me logo Genes that share ontologies with PAQR3: view

No data available for Pathways by source for PAQR3 Gene

Transcripts for PAQR3 Gene

Unigene Clusters for PAQR3 Gene

Progestin and adipoQ receptor family member III:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAQR3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PAQR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - -
SP8:
SP9:

Relevant External Links for PAQR3 Gene

GeneLoc Exon Structure for
PAQR3
ECgene alternative splicing isoforms for
PAQR3

Expression for PAQR3 Gene

mRNA expression in normal human tissues for PAQR3 Gene

mRNA differential expression in normal tissues according to GTEx for PAQR3 Gene

This gene is overexpressed in Testis (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAQR3 Gene

SOURCE GeneReport for Unigene cluster for PAQR3 Gene Hs.657312

mRNA Expression by UniProt/SwissProt for PAQR3 Gene

Q6TCH7-PAQR3_HUMAN
Tissue specificity: Widely expressed in a range of tissues.
genes like me logo Genes that share expressions with PAQR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PAQR3 Gene

Orthologs for PAQR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAQR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR3 35
  • 99.68 (n)
  • 99.68 (a)
PAQR3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAQR3 35
  • 93.68 (n)
  • 99.04 (a)
PAQR3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAQR3 35
  • 94.79 (n)
  • 99.35 (a)
PAQR3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paqr3 35
  • 90.89 (n)
  • 97.75 (a)
Paqr3 16
Paqr3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAQR3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAQR3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paqr3 35
  • 87.78 (n)
  • 97.43 (a)
chicken
(Gallus gallus)
Aves PAQR3 35
  • 80.56 (n)
  • 87.62 (a)
PAQR3 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAQR3 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr3 35
  • 78.39 (n)
  • 90.23 (a)
Str.15454 35
zebrafish
(Danio rerio)
Actinopterygii paqr3a 35
  • 71.12 (n)
  • 76.55 (a)
paqr3a 36
  • 76 (a)
OneToMany
paqr3b 36
  • 77 (a)
OneToMany
zgc73098 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000144 35
  • 48.02 (n)
  • 40.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7530 35
  • 48.57 (n)
  • 39.41 (a)
CG7530 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea paqr-3 35
  • 47.28 (n)
  • 34.81 (a)
paqr-3 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH1 36
  • 23 (a)
ManyToMany
IZH2 36
  • 21 (a)
ManyToMany
Species with no ortholog for PAQR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR3 Gene

ENSEMBL:
Gene Tree for PAQR3 (if available)
TreeFam:
Gene Tree for PAQR3 (if available)

Paralogs for PAQR3 Gene

Paralogs for PAQR3 Gene

Selected SIMAP similar genes for PAQR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PAQR3: view

Variants for PAQR3 Gene

Sequence variations from dbSNP and Humsavar for PAQR3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1275046 -- 78,917,354(+) CCTTG(C/G)TGGCT intron-variant
rs1275047 -- 78,917,608(+) AGCTG(A/C)TTCTT downstream-variant-500B, intron-variant
rs1299129 -- 78,917,522(+) AGGAC(C/T)GTATT downstream-variant-500B, intron-variant
rs1480718 -- 78,925,281(-) AATTT(C/T)TAGAT intron-variant
rs1564458 -- 78,919,802(-) TTAGC(C/T)ACCTA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR3 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
nsv879504 CNV Loss 21882294
nsv829979 CNV Gain 17160897

Relevant External Links for PAQR3 Gene

HapMap Linkage Disequilibrium report
PAQR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR3 Gene

Disorders for PAQR3 Gene

No disorders were found for PAQR3 Gene.

No data available for UniProtKB/Swiss-Prot for PAQR3 Gene

Publications for PAQR3 Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 2 3 4
  2. Characterization of the topology and functional domains of RKTG. (PMID: 18547165) Luo X. … Chen Y. (Biochem. J. 2008) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PAQR3 Gene

Sources for PAQR3 Gene

Back to Top

Content