Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PAPSS1 Gene

Aliases for PAPSS1 Gene

  • 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 2
  • 3-Phosphoadenosine 5-Phosphosulfate Synthase 1 2 3
  • Sulfurylase Kinase 1 3 4
  • PAPS Synthase 1 3 4
  • PAPSS 1 3 4
  • ATPSK1 3 4
  • PAPSS 3 4
  • SK 1 3 4
  • SK1 3 4
  • 3-Prime-Phosphoadenosine 5-Prime-Phosphosulfate Synthase 1 3
  • EC 2.7.1.25 63

External Ids for PAPSS1 Gene

Previous GeneCards Identifiers for PAPSS1 Gene

  • GC04M108945
  • GC04M108993
  • GC04M108892
  • GC04M108754
  • GC04M108534
  • GC04M104266

Summaries for PAPSS1 Gene

Entrez Gene Summary for PAPSS1 Gene

  • Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

GeneCards Summary for PAPSS1 Gene

PAPSS1 (3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1) is a Protein Coding gene. Diseases associated with PAPSS1 include chronic monocytic leukemia and atrophic glossitis. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include nucleotidyltransferase activity and sulfate adenylyltransferase (ATP) activity. An important paralog of this gene is PAPSS2.

UniProtKB/Swiss-Prot for PAPSS1 Gene

  • Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells

Gene Wiki entry for PAPSS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPSS1 Gene

Genomics for PAPSS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PAPSS1 Gene

Chromosome:
4
Start:
107,590,276 bp from pter
End:
107,720,452 bp from pter
Size:
130,177 bases
Orientation:
Minus strand

Genomic View for PAPSS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAPSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPSS1 Gene

No data available for Regulatory Elements for PAPSS1 Gene

Proteins for PAPSS1 Gene

  • Protein details for PAPSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43252-PAPS1_HUMAN
    Recommended name:
    Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1
    Protein Accession:
    O43252
    Secondary Accessions:
    • O43841
    • O75332
    • Q96FB1
    • Q96TF4
    • Q9P1P9
    • Q9UE98

    Protein attributes for PAPSS1 Gene

    Size:
    624 amino acids
    Molecular mass:
    70833 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PAPSS1 Gene

neXtProt entry for PAPSS1 Gene

Proteomics data for PAPSS1 Gene at MOPED

Selected DME Specific Peptides for PAPSS1 Gene

Post-translational modifications for PAPSS1 Gene

  • Ubiquitination at Lys 183 and Lys 619
  • Modification sites at PhosphoSitePlus

Other Protein References for PAPSS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PAPSS1 Gene

Graphical View of Domain Structure for InterPro Entry

O43252

UniProtKB/Swiss-Prot:

PAPS1_HUMAN :
  • In the N-terminal section; belongs to the APS kinase family.
Family:
  • In the N-terminal section; belongs to the APS kinase family.
  • In the C-terminal section; belongs to the sulfate adenylyltransferase family.
genes like me logo Genes that share domains with PAPSS1: view

No data available for Gene Families for PAPSS1 Gene

Function for PAPSS1 Gene

Molecular function for PAPSS1 Gene

GENATLAS Biochemistry:
3-phosphoadenosine 5 phosphosulfate synthase 1,member of sulfate activating enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + sulfate = diphosphate + adenylyl sulfate
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + adenylyl sulfate = ADP + 3-phosphoadenylyl sulfate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by chlorate
UniProtKB/Swiss-Prot Function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells

Enzyme Numbers (IUBMB) for PAPSS1 Gene

Gene Ontology (GO) - Molecular Function for PAPSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004020 adenylylsulfate kinase activity IBA --
GO:0004781 sulfate adenylyltransferase (ATP) activity ISS --
GO:0005524 ATP binding IEA --
GO:0016779 nucleotidyltransferase activity ISS --
genes like me logo Genes that share ontologies with PAPSS1: view
genes like me logo Genes that share phenotypes with PAPSS1: view

Animal Model Products

miRNA for PAPSS1 Gene

miRTarBase miRNAs that target PAPSS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAPSS1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PAPSS1 Gene

Localization for PAPSS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAPSS1 Gene COMPARTMENTS Subcellular localization image for PAPSS1 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
chloroplast 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PAPSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PAPSS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PAPSS1 Gene

Pathways & Interactions for PAPSS1 Gene

genes like me logo Genes that share pathways with PAPSS1: view

UniProtKB/Swiss-Prot O43252-PAPS1_HUMAN

  • Pathway: Sulfur metabolism; sulfate assimilation

Gene Ontology (GO) - Biological Process for PAPSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IEA --
GO:0001501 skeletal system development TAS 9771708
GO:0005975 carbohydrate metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PAPSS1: view

No data available for SIGNOR curated interactions for PAPSS1 Gene

Drugs & Compounds for PAPSS1 Gene

(6) Drugs for PAPSS1 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Glycerol Experimental Pharma Target 176
Adenosine-5'-Diphosphate-2',3'-Vanadate Experimental Pharma Target 0
Adenosine-5'-Phosphosulfate Experimental Pharma Target 0
Diphosphate Experimental Pharma 0

(10) Additional Compounds for PAPSS1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
3-Phosphoadenylylselenate
Adenosine phosphosulfate
  • Adenosine 5'-phosphosulfate
  • Adenosine 5'-phosphosulphate
  • Adenosine 5'-sulphatophosphate
  • Adenosine Phosphosulfate
  • Adenosine Phosphosulphate
485-84-7
Adenylylselenate
  • Adenosine-5'-phosphoselenate
  • Adenylylselenic acid
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PAPSS1: view

Transcripts for PAPSS1 Gene

Unigene Clusters for PAPSS1 Gene

3-phosphoadenosine 5-phosphosulfate synthase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAPSS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAPSS1 Gene

No ASD Table

Relevant External Links for PAPSS1 Gene

GeneLoc Exon Structure for
PAPSS1
ECgene alternative splicing isoforms for
PAPSS1

Expression for PAPSS1 Gene

mRNA expression in normal human tissues for PAPSS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAPSS1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (10.2), Lavage (6.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAPSS1 Gene



SOURCE GeneReport for Unigene cluster for PAPSS1 Gene Hs.368610

mRNA Expression by UniProt/SwissProt for PAPSS1 Gene

O43252-PAPS1_HUMAN
Tissue specificity: Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage
genes like me logo Genes that share expression patterns with PAPSS1: view

Protein tissue co-expression partners for PAPSS1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PAPSS1 Gene

Orthologs for PAPSS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PAPSS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAPSS1 35
  • 91.88 (n)
  • 98.4 (a)
-- 36
  • 77 (a)
OneToMany
PAPSS1 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PAPSS1 35
  • 93.54 (n)
  • 98.88 (a)
PAPSS1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Papss1 35
  • 87.98 (n)
  • 98.72 (a)
Papss1 16
Papss1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAPSS1 35
  • 94.79 (n)
  • 93.89 (a)
PAPSS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Papss1 35
  • 86.75 (n)
  • 97.42 (a)
oppossum
(Monodelphis domestica)
Mammalia PAPSS1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAPSS1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAPSS1 35
  • 81.89 (n)
  • 94.07 (a)
PAPSS1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAPSS1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia papss1 35
  • 80.13 (n)
  • 90.87 (a)
zebrafish
(Danio rerio)
Actinopterygii papss1 35
  • 75.05 (n)
  • 87.18 (a)
papss1 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Paps 37
  • 62 (a)
Papss 35
  • 61.29 (n)
  • 64.8 (a)
Papss 36
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001256 35
  • 59.43 (n)
  • 63.02 (a)
worm
(Caenorhabditis elegans)
Secernentea T14G10.1 37
  • 57 (a)
pps-1 36
  • 55 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13321g 35
  • 55.84 (n)
  • 54.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET14 35
  • 54.86 (n)
  • 58.86 (a)
MET14 36
  • 53 (a)
OneToMany
MET14 38
soybean
(Glycine max)
eudicotyledons Gma.2313 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12846 35
barley
(Hordeum vulgare)
Liliopsida Hv.12870 35
wheat
(Triticum aestivum)
Liliopsida Ta.9352 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09896 35
  • 57.19 (n)
  • 57.87 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes met14 35
  • 56.4 (n)
  • 53.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9328 36
  • 67 (a)
OneToMany
Species with no ortholog for PAPSS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PAPSS1 Gene

ENSEMBL:
Gene Tree for PAPSS1 (if available)
TreeFam:
Gene Tree for PAPSS1 (if available)

Paralogs for PAPSS1 Gene

Paralogs for PAPSS1 Gene

(1) SIMAP similar genes for PAPSS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PAPSS1: view

Variants for PAPSS1 Gene

Sequence variations from dbSNP and Humsavar for PAPSS1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_014064 -
VAR_014065 -

Structural Variations from Database of Genomic Variants (DGV) for PAPSS1 Gene

Variant ID Type Subtype PubMed ID
nsv830030 CNV Loss 17160897
nsv4456 CNV Loss 18451855
nsv528356 CNV Loss 19592680
nsv879712 CNV Loss 21882294

Variation tolerance for PAPSS1 Gene

Residual Variation Intolerance Score: 25.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAPSS1 Gene

HapMap Linkage Disequilibrium report
PAPSS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPSS1 Gene

Disorders for PAPSS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PAPSS1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic monocytic leukemia
  • leukemia, monocytic, chronic
atrophic glossitis
  • atrophy of tongue papillae
- elite association

Relevant External Links for PAPSS1

Genetic Association Database (GAD)
PAPSS1
Human Genome Epidemiology (HuGE) Navigator
PAPSS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAPSS1
genes like me logo Genes that share disorders with PAPSS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAPSS1 Gene

Publications for PAPSS1 Gene

  1. Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis. (PMID: 20089836) Cencetti F. … Bruni P. (Mol. Biol. Cell 2010) 23 67
  2. Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo. (PMID: 17436279) Stelzer C. … Dietz U.H. (Dev. Dyn. 2007) 23 67
  3. Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1. (PMID: 17276460) Sekulic N. … Lavie A. (J. Mol. Biol. 2007) 23 67
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26

Products for PAPSS1 Gene

Sources for PAPSS1 Gene

Back to Top

Content