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Aliases for PAPSS1 Gene

Aliases for PAPSS1 Gene

  • 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 2
  • 3-Phosphoadenosine 5-Phosphosulfate Synthase 1 2 3 5
  • Sulfate Adenylyltransferase 2 3
  • Adenylyl-Sulfate Kinase 2 3
  • Sulfurylase Kinase 1 3 4
  • PAPS Synthase 1 3 4
  • PAPSS 1 3 4
  • ATPSK1 3 4
  • PAPSS 3 4
  • SK 1 3 4
  • SK1 3 4
  • Bifunctional 3-Phosphoadenosine 5-Phosphosulfate Synthase 1 3
  • 3-Prime-Phosphoadenosine 5-Prime-Phosphosulfate Synthase 1 3
  • EC 2.7.1.25 61

External Ids for PAPSS1 Gene

Previous GeneCards Identifiers for PAPSS1 Gene

  • GC04M108945
  • GC04M108993
  • GC04M108892
  • GC04M108754
  • GC04M108534
  • GC04M104266

Summaries for PAPSS1 Gene

Entrez Gene Summary for PAPSS1 Gene

  • Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

GeneCards Summary for PAPSS1 Gene

PAPSS1 (3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1) is a Protein Coding gene. Diseases associated with PAPSS1 include Chronic Monocytic Leukemia. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include nucleotidyltransferase activity and sulfate adenylyltransferase (ATP) activity. An important paralog of this gene is PAPSS2.

UniProtKB/Swiss-Prot for PAPSS1 Gene

  • Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Gene Wiki entry for PAPSS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPSS1 Gene

Genomics for PAPSS1 Gene

Regulatory Elements for PAPSS1 Gene

Enhancers for PAPSS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F107692 1 Ensembl ENCODE 62.5 +26.9 26943 1.2 HDAC1 ATF1 JUN ZNF175 ZBTB40 FOXK2 ZNF584 ETV6 SMARCE1 L3MBTL2 PAPSS1 GC04P107697 LOC105377358
GH04F107718 1 ENCODE 36.5 +0.2 234 3.5 PKNOX1 ATF1 CREB3L1 DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 ELK1 PAPSS1 GC04P107697
GH04F107739 1 Ensembl ENCODE 34.6 -20.5 -20472 2.0 CTCF PKNOX1 CEBPG RAD21 SCRT2 ZNF600 SCRT1 NFIA HLF ZNF518A PAPSS1 GC04P107734 GC04P107803
GH04F107709 1.2 FANTOM5 Ensembl ENCODE 16.2 +10.2 10152 1.8 ZNF316 JUN MAFG NFE2 ETV6 BCL6 EMSY NFE2L2 PAPSS1 SGMS2 GC04P107697
GH04F107689 0.7 ENCODE 24.3 +30.0 29994 1.4 CTCF JUN BHLHE40 ZFP37 DPF2 GATA3 CTBP1 JUND FOSL2 FOS PAPSS1 GC04P107697 LOC105377358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAPSS1 on UCSC Golden Path with GeneCards custom track

Promoters for PAPSS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001246946 352 3401 PKNOX1 CREB3L1 DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 ELK1 KLF7

Genomic Location for PAPSS1 Gene

Chromosome:
4
Start:
107,590,276 bp from pter
End:
107,720,452 bp from pter
Size:
130,177 bases
Orientation:
Minus strand

Genomic View for PAPSS1 Gene

Genes around PAPSS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAPSS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAPSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPSS1 Gene

Proteins for PAPSS1 Gene

  • Protein details for PAPSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43252-PAPS1_HUMAN
    Recommended name:
    Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1
    Protein Accession:
    O43252
    Secondary Accessions:
    • O43841
    • O75332
    • Q96FB1
    • Q96TF4
    • Q9P1P9
    • Q9UE98

    Protein attributes for PAPSS1 Gene

    Size:
    624 amino acids
    Molecular mass:
    70833 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PAPSS1 Gene

neXtProt entry for PAPSS1 Gene

Selected DME Specific Peptides for PAPSS1 Gene

O43252:
  • TGLSGAGK
  • KGLYKKA

Post-translational modifications for PAPSS1 Gene

  • Ubiquitination at Lys 183 and Lys 619
  • Modification sites at PhosphoSitePlus

Other Protein References for PAPSS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PAPSS1 Gene

Graphical View of Domain Structure for InterPro Entry

O43252

UniProtKB/Swiss-Prot:

PAPS1_HUMAN :
  • In the N-terminal section; belongs to the APS kinase family.
Family:
  • In the N-terminal section; belongs to the APS kinase family.
  • In the C-terminal section; belongs to the sulfate adenylyltransferase family.
genes like me logo Genes that share domains with PAPSS1: view

No data available for Gene Families for PAPSS1 Gene

Function for PAPSS1 Gene

Molecular function for PAPSS1 Gene

GENATLAS Biochemistry:
3-phosphoadenosine 5 phosphosulfate synthase 1,member of sulfate activating enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + sulfate = diphosphate + adenylyl sulfate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + adenylyl sulfate = ADP + 3-phosphoadenylyl sulfate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by chlorate.
UniProtKB/Swiss-Prot Function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Enzyme Numbers (IUBMB) for PAPSS1 Gene

Gene Ontology (GO) - Molecular Function for PAPSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004020 adenylylsulfate kinase activity IBA,TAS --
GO:0004781 sulfate adenylyltransferase (ATP) activity ISS,TAS --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PAPSS1: view
genes like me logo Genes that share phenotypes with PAPSS1: view

Animal Model Products

miRNA for PAPSS1 Gene

miRTarBase miRNAs that target PAPSS1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAPSS1 Gene

Localization for PAPSS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAPSS1 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PAPSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PAPSS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PAPSS1 Gene

Pathways & Interactions for PAPSS1 Gene

genes like me logo Genes that share pathways with PAPSS1: view

UniProtKB/Swiss-Prot O43252-PAPS1_HUMAN

  • Pathway: Sulfur metabolism; sulfate assimilation.

Gene Ontology (GO) - Biological Process for PAPSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IEA --
GO:0001501 skeletal system development TAS 9771708
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA --
GO:0050428 3-phosphoadenosine 5-phosphosulfate biosynthetic process IBA,TAS --
genes like me logo Genes that share ontologies with PAPSS1: view

No data available for SIGNOR curated interactions for PAPSS1 Gene

Drugs & Compounds for PAPSS1 Gene

(6) Drugs for PAPSS1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Experimental Pharma Target 223
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Adenosine-5'-Diphosphate-2',3'-Vanadate Experimental Pharma Target 0
Adenosine-5'-Phosphosulfate Experimental Pharma Target 0

(10) Additional Compounds for PAPSS1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
3-Phosphoadenylylselenate
Adenosine phosphosulfate
  • Adenosine 5'-phosphosulfate
  • Adenosine 5'-phosphosulphate
  • Adenosine 5'-sulphatophosphate
  • Adenosine Phosphosulfate
  • Adenosine Phosphosulphate
485-84-7
Adenylylselenate
  • Adenosine-5'-phosphoselenate
  • Adenylylselenic acid
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PAPSS1: view

Transcripts for PAPSS1 Gene

Unigene Clusters for PAPSS1 Gene

3-phosphoadenosine 5-phosphosulfate synthase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAPSS1 Gene

No ASD Table

Relevant External Links for PAPSS1 Gene

GeneLoc Exon Structure for
PAPSS1
ECgene alternative splicing isoforms for
PAPSS1

Expression for PAPSS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAPSS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAPSS1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (10.2), Lavage (6.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAPSS1 Gene



Protein tissue co-expression partners for PAPSS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAPSS1 Gene:

PAPSS1

SOURCE GeneReport for Unigene cluster for PAPSS1 Gene:

Hs.368610

mRNA Expression by UniProt/SwissProt for PAPSS1 Gene:

O43252-PAPS1_HUMAN
Tissue specificity: Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.
genes like me logo Genes that share expression patterns with PAPSS1: view

Primer Products

No data available for mRNA differential expression in normal tissues for PAPSS1 Gene

Orthologs for PAPSS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PAPSS1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PAPSS1 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAPSS1 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAPSS1 34 35
  • 94.79 (n)
dog
(Canis familiaris)
Mammalia PAPSS1 34 35
  • 93.54 (n)
cow
(Bos Taurus)
Mammalia PAPSS1 34 35
  • 91.88 (n)
-- 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Papss1 34 16 35
  • 87.98 (n)
rat
(Rattus norvegicus)
Mammalia Papss1 34
  • 86.75 (n)
chicken
(Gallus gallus)
Aves PAPSS1 34 35
  • 81.89 (n)
lizard
(Anolis carolinensis)
Reptilia PAPSS1 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia papss1 34
  • 80.13 (n)
zebrafish
(Danio rerio)
Actinopterygii papss1 34 35
  • 75.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta Paps 36
  • 62 (a)
Papss 34 35
  • 61.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001256 34
  • 59.43 (n)
worm
(Caenorhabditis elegans)
Secernentea T14G10.1 36
  • 57 (a)
pps-1 35
  • 55 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13321g 34
  • 55.84 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET14 34 35 37
  • 54.86 (n)
soybean
(Glycine max)
eudicotyledons Gma.2313 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12846 34
barley
(Hordeum vulgare)
Liliopsida Hv.12870 34
wheat
(Triticum aestivum)
Liliopsida Ta.9352 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9328 35
  • 67 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09896 34
  • 57.19 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes met14 34
  • 56.4 (n)
Species where no ortholog for PAPSS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PAPSS1 Gene

ENSEMBL:
Gene Tree for PAPSS1 (if available)
TreeFam:
Gene Tree for PAPSS1 (if available)

Paralogs for PAPSS1 Gene

Paralogs for PAPSS1 Gene

(1) SIMAP similar genes for PAPSS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PAPSS1: view

Variants for PAPSS1 Gene

Sequence variations from dbSNP and Humsavar for PAPSS1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10002310 -- 107,684,653(+) ttctt(C/T)agaca intron-variant
rs10003562 -- 107,696,914(+) acatc(A/G)agagg intron-variant
rs10006012 -- 107,615,197(+) ACACA(C/G)AAAAG intron-variant
rs10022125 -- 107,620,274(+) AAAGC(A/G)GGTTA intron-variant
rs10024009 -- 107,683,977(+) ACACA(A/C)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAPSS1 Gene

Variant ID Type Subtype PubMed ID
nsv830030 CNV loss 17160897
nsv528356 CNV loss 19592680
nsv4456 CNV deletion 18451855
esv3601711 CNV gain 21293372
esv3601710 CNV gain 21293372
esv3601709 CNV gain 21293372
esv3433393 CNV insertion 20981092

Variation tolerance for PAPSS1 Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAPSS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAPSS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPSS1 Gene

Disorders for PAPSS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAPSS1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic monocytic leukemia
  • leukemia, myeloid
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PAPSS1

Genetic Association Database (GAD)
PAPSS1
Human Genome Epidemiology (HuGE) Navigator
PAPSS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAPSS1
genes like me logo Genes that share disorders with PAPSS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAPSS1 Gene

Publications for PAPSS1 Gene

  1. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization. (PMID: 10679223) Xu Z.-H. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
  2. Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase. (PMID: 9576487) Girard J.-P. … Amalric F. (FASEB J. 1998) 2 3 4 64
  3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  4. Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study. (PMID: 19337310) Shih W.L. … Liaw Y.F. (Eur. J. Hum. Genet. 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PAPSS1 Gene

Sources for PAPSS1 Gene

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