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Aliases for PAPPA2 Gene

Aliases for PAPPA2 Gene

  • Pappalysin 2 2 3 5
  • Pregnancy-Associated Plasma Protein E1 3 4
  • Placenta-Specific 3 2 3
  • PAPP-A2 3 4
  • PAPP-E 3 4
  • PLAC3 3 4
  • Pregnancy-Associated Plasma Preproprotein-A2 3
  • Pregnancy-Associated Plasma Protein A2 4
  • EC 3.4.24.- 4
  • PAPPE 3

External Ids for PAPPA2 Gene

Previous HGNC Symbols for PAPPA2 Gene

  • PLAC3

Previous GeneCards Identifiers for PAPPA2 Gene

  • GC01P173163
  • GC01P174698
  • GC01P147658

Summaries for PAPPA2 Gene

Entrez Gene Summary for PAPPA2 Gene

  • This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for PAPPA2 Gene

PAPPA2 (Pappalysin 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is PAPPA.

UniProtKB/Swiss-Prot for PAPPA2 Gene

  • Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Gene Wiki entry for PAPPA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPPA2 Gene

Genomics for PAPPA2 Gene

Regulatory Elements for PAPPA2 Gene

Enhancers for PAPPA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAPPA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAPPA2 Gene

176,463,171 bp from pter
176,845,605 bp from pter
382,435 bases
Plus strand

Genomic View for PAPPA2 Gene

Genes around PAPPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAPPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAPPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPPA2 Gene

Proteins for PAPPA2 Gene

  • Protein details for PAPPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A9Z1Y8
    • Q96PH7
    • Q96PH8
    • Q9H4C9

    Protein attributes for PAPPA2 Gene

    1791 amino acids
    Molecular mass:
    198539 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.
    • Sequence=AAL17779.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL17780.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC11134.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PAPPA2 Gene


neXtProt entry for PAPPA2 Gene

Proteomics data for PAPPA2 Gene at MOPED

Post-translational modifications for PAPPA2 Gene

  • Glycosylation at Asn 311, Asn 562, Asn 574, Asn 679, Asn 813, Asn 857, Asn 941, Asn 1243, Asn 1308, Asn 1326, Asn 1344, Asn 1408, Asn 1456, Asn 1476, and Asn 1694
  • Modification sites at PhosphoSitePlus

Other Protein References for PAPPA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PAPPA2 (Pappalysin-2/PAPP-A2)

No data available for DME Specific Peptides for PAPPA2 Gene

Domains & Families for PAPPA2 Gene

Gene Families for PAPPA2 Gene

Suggested Antigen Peptide Sequences for PAPPA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 Sushi (CCP/SCR) domains.
  • Belongs to the peptidase M43B family.
  • Contains 5 Sushi (CCP/SCR) domains.
  • Belongs to the peptidase M43B family.
genes like me logo Genes that share domains with PAPPA2: view

Function for PAPPA2 Gene

Molecular function for PAPPA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of the 143-Ser- -Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.
UniProtKB/Swiss-Prot Function:
Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Enzyme Numbers (IUBMB) for PAPPA2 Gene

Gene Ontology (GO) - Molecular Function for PAPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
genes like me logo Genes that share ontologies with PAPPA2: view
genes like me logo Genes that share phenotypes with PAPPA2: view

Animal Models for PAPPA2 Gene

MGI Knock Outs for PAPPA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PAPPA2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAPPA2 Gene

Localization for PAPPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAPPA2 Gene


Subcellular locations from

Jensen Localization Image for PAPPA2 Gene COMPARTMENTS Subcellular localization image for PAPPA2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PAPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PAPPA2: view

Pathways & Interactions for PAPPA2 Gene

genes like me logo Genes that share pathways with PAPPA2: view

Gene Ontology (GO) - Biological Process for PAPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060349 bone morphogenesis IEA --
genes like me logo Genes that share ontologies with PAPPA2: view

No data available for SIGNOR curated interactions for PAPPA2 Gene

Drugs & Compounds for PAPPA2 Gene

No Compound Related Data Available

Transcripts for PAPPA2 Gene

Unigene Clusters for PAPPA2 Gene

Pappalysin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAPPA2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12

Relevant External Links for PAPPA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAPPA2 Gene

mRNA expression in normal human tissues for PAPPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAPPA2 Gene

This gene is overexpressed in Cervix - Ectocervix (x4.6) and Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for PAPPA2 Gene

This gene is overexpressed in Vitreous humor (60.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAPPA2 Gene

SOURCE GeneReport for Unigene cluster for PAPPA2 Gene Hs.187284

mRNA Expression by UniProt/SwissProt for PAPPA2 Gene

Tissue specificity: Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.
genes like me logo Genes that share expression patterns with PAPPA2: view

Protein tissue co-expression partners for PAPPA2 Gene

Primer Products

Orthologs for PAPPA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAPPA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PAPPA2 35
  • 85.09 (n)
  • 80.65 (a)
  • 80 (a)
(Canis familiaris)
Mammalia PAPPA2 35
  • 85.73 (n)
  • 82.27 (a)
  • 85 (a)
(Mus musculus)
Mammalia Pappa2 35
  • 82.39 (n)
  • 79.35 (a)
Pappa2 16
Pappa2 36
  • 79 (a)
(Pan troglodytes)
Mammalia PAPPA2 35
  • 99.59 (n)
  • 99.44 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC680415 35
  • 82.34 (n)
  • 79.69 (a)
(Monodelphis domestica)
Mammalia PAPPA2 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia PAPPA2 36
  • 52 (a)
(Gallus gallus)
Aves PAPPA2 35
  • 69.01 (n)
  • 66.73 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia PAPPA2 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pappa2 35
  • 59.99 (n)
  • 55.55 (a)
(Danio rerio)
Actinopterygii pappa2 35
  • 57.46 (n)
  • 51.76 (a)
pappa2 36
  • 49 (a)
Species with no ortholog for PAPPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAPPA2 Gene

Gene Tree for PAPPA2 (if available)
Gene Tree for PAPPA2 (if available)

Paralogs for PAPPA2 Gene

Paralogs for PAPPA2 Gene

(1) SIMAP similar genes for PAPPA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PAPPA2: view

Variants for PAPPA2 Gene

Sequence variations from dbSNP and Humsavar for PAPPA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs36112782 - 176,556,834(+) TGCCA(C/G)TACTA nc-transcript-variant, reference, missense
rs34602579 - 176,791,432(+) ACCCC(A/C/G/T)CTCAG nc-transcript-variant, reference, missense
rs11141 -- 176,555,874(+) CGAGG(A/C)GTGTG nc-transcript-variant, utr-variant-5-prime
rs12610 -- 176,844,479(+) GGAAA(A/T)GGAAA utr-variant-3-prime
rs12707 -- 176,845,328(+) GAATG(A/G)GCAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PAPPA2 Gene

Variant ID Type Subtype PubMed ID
nsv831970 CNV Gain 17160897
nsv511719 CNV Loss 21212237
esv2467680 CNV Deletion 19546169
esv2094934 CNV Deletion 18987734
esv2719795 CNV Deletion 23290073
esv1170602 CNV Deletion 17803354
esv6740 CNV Loss 19470904
nsv159940 CNV Loss 16902084
esv275585 CNV Loss 21479260
esv2669646 CNV Deletion 23128226
nsv831982 CNV Gain 17160897
esv992315 CNV Deletion 20482838
esv1005770 CNV Deletion 20482838
esv1596288 CNV Deletion 17803354
nsv3666 CNV Loss 18451855
esv28963 CNV Loss 19812545
esv2669673 CNV Deletion 23128226
nsv498694 CNV Loss 21111241
nsv818589 CNV Loss 17921354
nsv466094 CNV Loss 19166990
esv33914 CNV Gain 17666407
nsv466105 CNV Loss 19166990
esv275131 CNV Gain+Loss 21479260
nsv508049 CNV Loss 20534489

Variation tolerance for PAPPA2 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PAPPA2 Gene

Disorders for PAPPA2 Gene

Relevant External Links for PAPPA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PAPPA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAPPA2 Gene

Publications for PAPPA2 Gene

  1. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin- like growth factor-binding protein-5 proteinase. (PMID: 11264294) Overgaard M.T. … Oxvig C. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Pregnancy-associated plasma protein-E (PAPP-E). (PMID: 11018262) Farr M. … Tschesche H. (Biochim. Biophys. Acta 2000) 2 3 23
  3. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. (PMID: 18818296) Winn V.D. … Fisher S.J. (Endocrinology 2009) 3 23
  4. Seven placental transcripts characterize HELLP-syndrome. (PMID: 18374411) Buimer M. … Ris-Stalpers C. (Placenta 2008) 3 23
  5. The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant. (PMID: 11597188) Page N.M. … Lowry P.J. (Placenta 2001) 3 23

Products for PAPPA2 Gene

Sources for PAPPA2 Gene