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PAPPA2 Gene

protein-coding   GIFtS: 60
GCID: GC01P176432

Pappalysin 2

(Previous name: placenta-specific 3)
(Previous symbol: PLAC3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pappalysin 21 2     PAPPE2
PLAC31 2 3     pappalysin-22
Placenta-Specific 31 2     Pregnancy-Associated Plasma Preproprotein-A22
Pregnancy-Associated Plasma Protein E12 3     EC 3.4.24.-3
PAPP-A22 3     Pregnancy-Associated Plasma Protein A23
PAPP-E2 3     

External Ids:    HGNC: 146151   Entrez Gene: 606762   Ensembl: ENSG000001161837   UniProtKB: Q9BXP83   

Export aliases for PAPPA2 gene to outside databases

Previous GC identifers: GC01P173163 GC01P174698 GC01P147658


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAPPA2 Gene:
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves
insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor
(IGF) bioavailability. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul
2010)

GeneCards Summary for PAPPA2 Gene:
PAPPA2 (pappalysin 2) is a protein-coding gene. GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is PAPPA.

UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8
Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3

Gene Wiki entry for PAPPA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAPPA2 gene promoter:
         STAT1   Tal-1   HTF   Lmo2   Cdc5   GATA-1   E47   FOXJ2 (long isoform)   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAPPA2 promoter sequence
   Search Chromatin IP Primers for PAPPA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAPPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23-q25   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q23-q25

PAPPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAPPA2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P176432:  view genomic region     (about GC identifiers)

Start:
176,432,307 bp from pter      End:
176,814,735 bp from pter
Size:
382,429 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8 (See protein sequence)
Recommended Name: Pappalysin-2 precursor  
Size: 1791 amino acids; 198539 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Monomer
Sequence caution: Sequence=AAL17779.1; Type=Erroneous initiation; Sequence=AAL17780.1; Type=Erroneous initiation;
Sequence=CAC11134.1; Type=Erroneous initiation;
Secondary accessions: A9Z1Y8 Q96PH7 Q96PH8 Q9H4C9
Alternative splicing: 2 isoforms:  Q9BXP8-1   Q9BXP8-2   

Explore the universe of human proteins at neXtProt for PAPPA2: NX_Q9BXP8

Explore proteomics data for PAPPA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn311, Asn562, Asn574, Asn679, Asn813, Asn857, Asn941, Asn1243, Asn1308, Asn1326,
                                 Asn1344, Asn1408, Asn1456, Asn1476, Asn1694
  • Modification sites at PhosphoSitePlus

  • See PAPPA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_064714.2  NP_068755.2  

    ENSEMBL proteins: 
     ENSP00000356633   ENSP00000356634  
    Reactome Protein details: Q9BXP8

    PAPPA2 Human Recombinant Protein Products:

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    antibodies-online proteins for PAPPA2 (2 products) 

     
    antibodies-online peptides for PAPPA2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR011936 Myxo_disulph_rpt
     IPR003961 Fibronectin_type3
     IPR013320 ConA-like_subgrp
     IPR000436 Sushi_SCR_CCP
     IPR008754 Peptidase_M43

    Graphical View of Domain Structure for InterPro Entry Q9BXP8

    ProtoNet protein and cluster: Q9BXP8

    2 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB002052 N-6 Adenine-specific DNA methylase


    UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8
    Similarity: Belongs to the peptidase M43B family
    Similarity: Contains 5 Sushi (CCP/SCR) domains


    Find genes that share domains with PAPPA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAPP2_HUMAN, Q9BXP8
    Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3
    Catalytic activity: Cleavage of the 143-Ser- -Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity IDA11264294
    GO:0008270zinc ion binding NAS11264294
         
    Find genes that share ontologies with PAPPA2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PAPPA2:
     Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pappa2):
     cardiovascular system  craniofacial  growth/size/body  hematopoietic system  immune system 
     limbs/digits/tail  liver/biliary system  nervous system  reproductive system  skeleton 

    Find genes that share phenotypes with PAPPA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PAPPA2: Pappa2tm1.1Jkcs Pappa2tm1Lex

       genOway: Develop your customized and physiologically relevant rodent model for PAPPA2

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    1 qRT-PCR Assays for microRNA that regulate PAPPA2:
    hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidPAPPA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PAPPA2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAPP2_HUMAN, Q9BXP8: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular NAS11264294
    GO:0016020membrane IEA--

    Find genes that share ontologies with PAPPA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAPPA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


    Find genes that share SuperPaths with PAPPA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PAPPA2
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAPPA2
    Interactions:

        Search GeneGlobe Interaction Network for PAPPA2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for PAPPA2 (Q9BXP82, 3 ENSP000003566344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3, ENSP000002611684MINT-61886 I2D: score=3 STRING: ENSP00000261168
    ZNF512BQ96KM62, 3MINT-60821 MINT-60813 I2D: score=3 
    SMAD4Q134852, 3, ENSP000003415514MINT-61944 I2D: score=3 STRING: ENSP00000341551
    IGFBP5P245933, ENSP000002338134I2D: score=1 STRING: ENSP00000233813
    IGFBP3P179363, ENSP000003704734I2D: score=2 STRING: ENSP00000370473
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS11264294
    GO:0006508proteolysis IDA11264294
    GO:0030154cell differentiation IEA--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with PAPPA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAPPA2 (PAPP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PAPPA2 gene (2 alternative transcripts): 
    NM_020318.2  NM_021936.2  

    Unigene Cluster for PAPPA2:

    Pappalysin 2
    Hs.187284  [show with all ESTs]
    Unigene Representative Sequence: BC152552
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367661(uc001gky.1) ENST00000367662(uc001gkz.3 uc009www.3)
    ENST00000493665 ENST00000486075 ENST00000479836
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate PAPPA2:
    hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidPAPPA2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PAPPA2
      QuantiFast Probe-based Assays in human, mouse, rat PAPPA2

    Additional mRNA sequence: 

    AB209369.1 AF311940.1 AF342989.1 AF342990.1 AJ278348.1 AK096718.1 BC062665.1 BC104644.1 
    BC117193.1 BC117195.1 BC152552.1 BX649062.1 

    9 DOTS entries:

    DT.317112  DT.100783980  DT.86854281  DT.99979105  DT.91759944  DT.92420323  DT.95128620  DT.91741120 
    DT.95369620 

    Selected AceView cDNA sequences (see all 233):

    CR590333 BF589540 BE501917 BF196448 AA059406 AI151429 AI435078 AI127580 
    AA233323 BU633638 AI088411 AL554447 CR606104 BQ021951 BU752090 AA046497 
    BF990233 AA047826 CF527876 BX439558 CR621436 BQ028475 BM723192 AF311940 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PAPPA2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for PAPPA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAPPA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PAPPA2 Expression
    About this image


    PAPPA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Neural Tube (Nervous System)
             Mesencephalic Basal Plate
     
     Kidney (Urinary System)
     
     Placenta (Extraembryonic Tissues)
    PAPPA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAPPA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.187284

    UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8
    Tissue specificity: Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the
    kidney, fetal brain and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPPA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PAPPA2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pappa21 , 5 pappalysin 21, 5 82.39(n)1
    79.35(a)1
      1 (68.49 cM)5
    238501  NM_001085376.21  NP_001078845.11 
     1587117275 
    chicken
    (Gallus gallus)
    Aves PAPPA21 pappalysin 2 69.01(n)
    66.73(a)
      429071  XM_426627.4  XP_426627.4 
    lizard
    (Anolis carolinensis)
    Reptilia PAPPA26
    pappalysin 2
    65(a)
    1 ↔ 1
    4(72806606-72949287)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pappa21 pappalysin 2 59.99(n)
    55.55(a)
      100491868  XM_002931469.2  XP_002931515.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pappa21 pappalysin 2 57.46(n)
    51.76(a)
      567038  XM_690325.4  XP_695417.4 


    ENSEMBL Gene Tree for PAPPA2 (if available)
    TreeFam Gene Tree for PAPPA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAPPA2 gene
    PAPPA2  
    1 SIMAP similar gene for PAPPA2 using alignment to 1 protein entry:     PAPP2_HUMAN:
    PAPPA

    Find genes that share paralogs with PAPPA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAPPA2 (see all 6751)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388298091,2
    C--147732552(+) ATGGA-/GTGTGTG 2 -- int10--------
    rs576023441,2
    C--147732589(+) TGTGT-/GTGTGT
    /GTGTGTGT
    ATGTA
    4 -- int1 cds11NA 2
    rs353946391,2
    C--147760637(+) TGCAC-/AATGAG 2 -- int11Minor allele frequency- A:0.00NA 2
    rs341541041,2
    C--147815351(+) ATAAT-/AAAACA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs121199091,2
    C,A--147862088(+) GTGTGA/TGAGAG 2 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs557420861,2
    C--147862088(+) GTGTG-/GAG   
      AGA
    /TG
    AGAGA
    4 -- int1 cds10--------
    rs1399677431,2
    C--147903988(+) CATGT-/AGAGAG/
    AGAGAGAGAG
    AGAGA
    2 -- int1 cds10--------
    rs342214241,2
    C--147917875(+) TTTTTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs347652291,2
    C--147929848(+) ACACA-/AC/CA 
            
    AACTC
    1 -- int11CSA 2
    rs718791931,2
    C--147992093(+) TTCTT-/TTTC  
            
    TTCTT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for PAPPA2 (176432307 - 176682307 bp, first 250kb of PAPPA2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PAPPA2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719795CNV Deletion23290073
    esv1596288CNV Deletion17803354
    esv992315CNV Deletion20482838
    esv1170602CNV Deletion17803354
    esv2669646CNV Deletion23128226
    esv2467680CNV Deletion19546169
    esv2669673CNV Deletion23128226
    esv2094934CNV Deletion18987734
    esv1005770CNV Deletion20482838
    nsv3666CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PAPPA2
    DNA2.0 Custom Variant and Variant Library Synthesis for PAPPA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease from the University of Copenhagen DISEASES database for PAPPA2:
    pre-eclampsia

    Find genes that share disorders with PAPPA2           About GenesLikeMe

    2 Novoseek inferred disease relationships for PAPPA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trisomy 48.8 2 11018262 (1), 11597188 (1)
    down syndrome 40.8 2 11018262 (1), 11597188 (1)

    Genetic Association Database (GAD): PAPPA2
    Human Genome Epidemiology (HuGE) Navigator: PAPPA2 (3 documents)

    Export disorders for PAPPA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PAPPA2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with PAPPA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin- like growth factor-binding protein-5 proteinase. (PubMed id 11264294)1, 2, 3, 9 Overgaard M.T.... Oxvig C. (J. Biol. Chem. 2001)
    2. Pregnancy-associated plasma protein-E (PAPP-E). (PubMed id 11018262)1, 2, 3, 9 Farr M....Tschesche H. (Biochim. Biophys. Acta 2000)
    3. The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant. (PubMed id 11597188)1, 2, 9 Page N.M.... Lowry P.J. (Placenta 2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. (PubMed id 18818296)1, 9 Winn V.D....Fisher S.J. (Endocrinology 2009)
    8. Seven placental transcripts characterize HELLP-syndrome. (PubMed id 18374411)1, 9 Buimer M....Ris-Stalpers C. (Placenta 2008)
    9. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PubMed id 23509962)1 Greliche N....TrAcgouAt D.A. (BMC Med. Genet. 2013)
    10. Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-A2 with developmental dysplasia of the hip: a case-control study. (PubMed id 22037112)1 Jia J....Shi L. (Osteoarthr. Cartil. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 60676 HGNC: 14615 AceView: PAPPA2 Ensembl:ENSG00000116183 euGenes: HUgn60676
    ECgene: PAPPA2 H-InvDB: PAPPA2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PAPPA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PAPPA2 gene:
    Search GeneIP for patents involving PAPPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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