PAPPA2 Gene
protein-coding GIFtS: 57
GCID: GC01P176432
|
|
pappalysin 2(Previous name: placenta-specific 3 )
(Previous symbol: PLAC3)
| |
Aliases
for PAPPA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pappalysin 21 2 | | PAPP-E2 3 | | PAPP-A21 2 3 | | Pappalysin-21 | | PLAC31 2 3 | | Pregnancy-Associated Plasma Preproprotein-A22 | | PAPPE1 2 | | EC 3.4.24.-3 | | Placenta-Specific 31 2 | | Pregnancy-Associated Plasma Protein A23 | | Pregnancy-Associated Plasma Protein E12 3 | | |
Export aliases for PAPPA2 gene to outside databasesPrevious GC identifers: GC01P173163 GC01P174698 GC01P147658 |
Summaries
for PAPPA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PAPPA2:
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleavesinsulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor(IGF) bioavailability. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2010)
UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3
Gene Wiki entry for PAPPA2
|
Genomic Views
for PAPPA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PAPPA2 gene promoter:
STAT1 Tal-1 HTF Lmo2 Cdc5 GATA-1 E47 FOXJ2 (long isoform) Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PAPPA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAPPA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23-q25 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q23-q25PAPPA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P176432: view genomic region
(about GC identifiers)
Start:
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176,432,307 bp from pter |
End:
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176,814,735 bp from pter |
Size:
|
382,429 bases |
Orientation:
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plus strand |
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Proteins
for PAPPA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8 (See
protein sequence)Recommended Name: Pappalysin-2 precursor Size: 1791 amino acids; 198539 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Monomer
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=AAL17779.1; Type=Erroneous initiation; Sequence=AAL17780.1; Type=Erroneous initiation;Sequence=CAC11134.1; Type=Erroneous initiation;
Secondary accessions: A9Z1Y8 Q96PH7 Q96PH8 Q9H4C9Alternative splicing: 2 isoforms: Q9BXP8-1 Q9BXP8-2 Explore the universe of human proteins at neXtProt for PAPPA2: NX_Q9BXP8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXP8
PAPPA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_064714.2 NP_068755.2
ENSEMBL proteins: ENSP00000356634 ENSP00000356633 Reactome Protein details: Q9BXP8
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PAPPA2 for ontologies About GeneDecksing
PAPPA2 Antibody Products:
Assay Products for PAPPA2: |
Protein
Domains /
Families
for PAPPA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PAPPA2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9BXP8ProtoNet protein and cluster: Q9BXP8 2 Blocks protein families: IPB000436 Sushi domain/SCR domain/CCP module IPB002052 N-6 Adenine-specific DNA methylase
UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8Similarity: Belongs to the peptidase M43B familySimilarity: Contains 5 Sushi (CCP/SCR) domains |
Function
for PAPPA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3Catalytic activity: Cleavage of the 143-Ser- -Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5Enzyme Number (IUBMB): EC 3.4.24.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAPPA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAPPA2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for PAPPA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAPPA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPPA2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
PAPPA2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PAPPA2:
Animal Models:
Mouse knock-out Pappa2tm1Lex for PAPPA2
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pappa2):
PAPPA2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PAPPA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for PAPPA2
PAPPA2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAPPA2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for PAPPA2 (Q9BXP82, 3 ENSP000003566344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
PAPPA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PAPPA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PAPPA2
Search CenterWatch for drugs/clinical trials and news about PAPPA2 / PAPP2
|
Transcripts
for PAPPA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PAPPA2 gene (2 alternative transcripts): NM_020318.2 NM_021936.2 Unigene Cluster for PAPPA2: Pappalysin 2 Hs.187284 [show with all ESTs]Unigene Representative Sequence: BC1525525 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367662(uc001gkz.3 uc009www.3) ENST00000367661(uc001gky.1)
ENST00000493665 ENST00000486075 ENST00000479836
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAPPA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAPPA2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PAPPA2 (NM_021936) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAPPA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAPPA2 |
Additional cDNA sequence: AB209369.1 AF311940.1 AF342989.1 AF342990.1 AJ278348.1 AK096718.1 BC062665.1 BC104644.1 BC117193.1 BC117195.1 BC152552.1 BX649062.1 9 DOTS entries: DT.317112 DT.100783980 DT.86854281 DT.99979105 DT.91759944 DT.92420323 DT.95128620 DT.91741120 DT.95369620 24/233 AceView cDNA sequences (see all 233): AA151581 AA256967 BQ028475 N41334 AA046497 BC062665 BQ021951 AI189129 AI221072 AF342989 N40761 BX649062 BF987746 BI057213 NM_020318 CF527876 BF995327 BF990233 AA047826 AI129688 BU752090 AL554447 AA059406 BU633638
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PAPPA2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PAPPA2
|
Expression
for PAPPA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PAPPA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PAPPA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAPPA2
SOURCE GeneReport for Unigene cluster: Hs.187284
UniProtKB/Swiss-Prot: PAPP2_HUMAN, Q9BXP8Tissue specificity: Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney,fetal brain and pancreas
SABiosciences Custom PCR Arrays for PAPPA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAPPA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PAPPA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAPPA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAPPA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPPA2 |
Orthologs
for PAPPA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PAPPA2 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for PAPPA2 (if available)
TreeFam Gene Tree for PAPPA2 (if available) |
Paralogs
for PAPPA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PAPPA2 gene
- PAPPA2
1 SIMAP similar gene for PAPPA2 using alignment to 1 protein entry: PAPP2_HUMAN:PAPPA
PAPPA2 for paralogs About GeneDecksing
|
Genomic Variants
for PAPPA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PAPPA2 (176432307 - 176682307 bp, first 250kb of PAPPA2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for PAPPA2
6 CNVs: 34737 74784 97563 9901 84670 65290
5 Indels: 44471 11424 24006 60907 11009 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAPPA2 |
|
Disorders
/ Diseases
for PAPPA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PAPPA2 for disorders About GeneDecksing
4  diseases for PAPPA2: About MalaCardspre-eclampsia down syndrome hellp syndrome eclampsia
1 disease from the University of Copenhagen DISEASES database for PAPPA2:pre-eclampsia 2 Novoseek disease relationships for PAPPA2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| trisomy |
48.8 |
2 |
11018262 (1), 11597188 (1) |
| down syndrome |
40.8 |
2 |
11018262 (1), 11597188 (1) |
Human Genome Epidemiology (HuGE) Navigator: PAPPA2 (3 documents)
Export disorders for PAPPA2 gene to outside databases
|
Publications
for PAPPA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PAPPA2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with PAPPA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin- like growth factor-binding protein-5 proteinase. (PubMed id 11264294)1, 2, 3, 9 Overgaard M.T.... Oxvig C. (2001)
- Pregnancy-associated plasma protein-E (PAPP-E). (PubMed id 11018262)1, 2, 3, 9 Farr M....Tschesche H. (2000)
- The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant. (PubMed id 11597188)1, 2, 9 Page N.M.... Lowry P.J. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. (PubMed id 18818296)1, 9 Winn V.D....Fisher S.J. (2009)
- Seven placental transcripts characterize HELLP-syndrome. (PubMed id 18374411)1, 9 Buimer M....Ris-Stalpers C. (2008)
- Association of a single nucleotide polymorphism in pre gnancy-associated plasma protein-A2 with developmental dysplasia of the hip: a c ase-control study. (PubMed id 22037112)1 Jia J....Shi L. (2012)
- Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo). (PubMed id 21496272)1 Wagner P.K....Christians J.K. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A meta-analysis of four genome-wide association studi es of survival to age 90 years or older: the Cohorts for Heart and Aging Resear ch in Genomic Epidemiology Consortium. (PubMed id 20304771)1 Newman A.B....Murabito J.M. (2010)
|
External Searches for PAPPA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PAPPA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PAPPA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PAPPA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PAPPA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PAPPA2 gene:
Search GeneIP for patents involving PAPPA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PAPPA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PAPPA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAPPA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAPPA2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PAPPA2 | | OriGene 3'-UTR Clone for PAPPA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAPPA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAPPA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PAPPA2 | | OriGene Custom Protein Services for PAPPA2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PAPPA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAPPA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAPPA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAPPA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAPPA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAPPA2 |
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| | | | Search Tocris compounds for PAPPA2 |
| |  |  |  |  | | | | |
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 | | | PAPPA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPPA2 |
|  |  |  | | | | ThermoFisher Antibodies for PAPPA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAPPA2 |
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