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PAPPA Gene

protein-coding GIFtS: 62

GC09P117955

pregnancy-associated plasma protein A, pappalysin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ASBABP2 ^¹, ²
DIPLA1 ^¹, ²
EC 3.4.24.79 ^³
IGFBP-4ase ^¹, ², ³
OTTHUMP00000022806 ^²
PAPA ^¹, ²
PAPP-A ^¹, ², ³
PAPPA1 ^¹, ²

Descriptions
IGF-dependent IGFBP-4 protease ^³
Insulin-like growth factor-dependent IGF-binding protein 4 protease ^³
Pregnancy-associated plasma protein A ^², ³
aspecific BCL2 ARE-binding protein 2 ^²
differentially placenta 1 expressed protein ^²
insulin-like growth factor-dependent IGF binding protein-4 protease ^²
pregnacy-associated plasma protein A ^²
pregnancy-associated plasma protein A, pappalysin 1 ^²

External Ids
HGNC: 8602¹
Entrez Gene: 5069²
UniProtKB: Q13219³
Ensembl: ENSG00000182752⁷

Search outside databases for aliases for PAPPA gene

Previous GC identifers: GC09P109744 GC09P110677 GC09P112369 GC09P114292 GC09P115995

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAPPA:

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding

proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound

healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical

marker for pregnancies with aneuploid fetuses. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAPP1_HUMAN, Q13219

Function: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of

bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage

of IGFBP-5 is slightly inhibited by the presence of IGF

Gene Wiki entry for PAPPA (Pregnancy-associated_plasma_protein_A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAPPA gene

Entrez Gene cytogenetic band: 9q33.2 Ensembl cytogenetic band: 9q33.1 HGNC cytogenetic band: 9q33.1

PAPPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P117955: (about GC identifiers)

Start:	117,955,892 bp from pter
End:	118,204,421 bp from pter
Size:	248,530 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PAPP1_HUMAN, Q13219 (See protein sequence)

Recommended Name: Pappalysin-1 precursor

Size: 1627 amino acids; 180973 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked

2:2 heterotetramer with the proform of PRG2

Subcellular location: Secreted

Developmental stage: Present in serum and placenta during pregnancy; levels increase throughout

pregnancy

Sequence caution: Sequence=AAC50543.1; Type=Frameshift; Positions=51, 67;

Secondary accessions: B1AMF9 Q08371 Q68G52 Q9UDK7

Post-translational modifications:

There appear to be no free sulfhydryl groups¹

REFSEQ proteins: NP_002572.2

ENSEMBL proteins:

ENSP00000330658

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for PAPPA (Pappalysin-1/PAPP-A)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PAPP A)
	Human Recombinant Proteins from Abnova (PAPPA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	10913121
GO:0016020	membrane	IEA	--

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Antibodies for PAPPA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PAPPA
	R&D Systems Antibodies for PAPPA (Pappalysin-1/PAPP-A)
	Antibodies from Abcam (PAPP A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAPPA)
	Novus Biologicals Antibodies for PAPPA

Assays for PAPPA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for PAPPA (Pappalysin-1/PAPP-A) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13219

ProtoNet protein and cluster: Q13219

1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module

UniProtKB/Swiss-Prot: PAPP1_HUMAN, Q13219

Similarity: Belongs to the peptidase M43B family

Similarity: Contains 5 Sushi (CCP/SCR) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAPPA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAPPA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002581

Applied Biosystems Silencer® siRNAs for PAPPA

Sigma-Aldrich siRNA and siRNA Panels for PAPPA

Sigma-Aldrich shRNA for PAPPA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002581
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002581
untagged cDNA clones in CMV expression vector (see all 2): NM_002581

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002581

UniProtKB/Swiss-Prot: PAPP1_HUMAN, Q13219

Function: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of

bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage

of IGFBP-5 is slightly inhibited by the presence of IGF

Catalytic activity: Cleavage of the 135-Met- -Lys-136 bond in insulin-like growth factor binding

protein (IGFBP)-4, and the 143-Ser- -Lys-144 bond in IGFBP-5

Enzyme regulation: Inhibited by complexation with the proform of PRG2

Induction: By 8-bromoadenosine-3',5'-phosphate

Enzyme Number (IUBMB): EC 3.4.24.79

Genatlas biochemistry entry for PAPPA:

pregnancy-associated plasma protein A

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pappa):

growth/size

skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008233	peptidase activity	IEA	--
GO:0008237	metallopeptidase activity	NAS	10913121
GO:0008270	zinc ion binding	NAS	10077652 10913121
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for PAPPA (Your Favorite Gene powered by Ingenuity)

Lysine Degradation

GeneDecks PAPPA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PAPPA

5/21 Interacting proteins for PAPPA (ENSP00000330658³ Q13219²) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD9	O15198²	MINT-62089
IGF1	ENSP00000302665³	STRING (score=.996)
IGFBP4	ENSP00000269593³	STRING (score=.994)
PRG2	ENSP00000312134³	STRING (score=.976)
IGFBP5	ENSP00000233813³	STRING (score=.97)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007565	female pregnancy	NAS	10077652 10913121
GO:0030154	cell differentiation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAPPA
10/20 Novoseek chemical compound relationships for PAPPA gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oestriol	71.64	18	7530437 (2), 10416969 (2), 8624312 (2), 10416963 (1) (see all 8)
aopp	50.92	6	14739577 (2), 15354943 (1), 17191033 (1)
pentosidine	25.84	3	15208163 (2), 14605280 (1)
glycosaminoglycan	24.19	9	17145752 (2), 15066178 (1), 7508748 (1), 17040968 (1)
progesterone	22.74	31	18402945 (4), 11750960 (4), 16055453 (4), 8473440 (3) (see all 11)
glucose	2.25	7	15208163 (2), 18362295 (2), 1693271 (1), 17229078 (1) (see all 5)
tyrosine	1.67	2	12571229 (1), 16258339 (1)
lipid	1.31	6	14661010 (2), 18362295 (2), 16706128 (1)
calcium	1.09	6	17243917 (2), 18000148 (1), 15262980 (1)
estradiol	0.00	6	15271447 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAPPA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAPPA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002581

Sigma-Aldrich siRNA and siRNA Panels for PAPPA

Sigma-Aldrich shRNA for PAPPA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002581

REFSEQ mRNAs for PAPPA gene:

NM_002581.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002581

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002581
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002581
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002581

Additional cDNA sequence:

AK094182.1 AY623011.1 AY623012.1 CR597268.1

24/61 DOTS entries (see all 61 ):

DT.91861595 DT.100822197 DT.91811577 DT.100822192 DT.97813532 DT.449795 DT.95260887 DT.40116919

DT.121144171 DT.119830 DT.86995514 DT.92012680 DT.40281278 DT.95260886 DT.101964341 DT.100824983

DT.121144072 DT.121144182 DT.95260898 DT.91974823 DT.75136774 DT.121144237 DT.91771685 DT.95176951

24/1048 AceView cDNA sequences (see all 1048 ):

BF992397 AU135944 BG012577 AU141023 AU140651 AA705356 AA595787 AU134784

AU140928 AA620683 AU141017 BF990581 AI057251 AU140334 AU140381 AI492481

AU140498 BU752032 BX640901 AU140460 AA368580 AI168453 AU140431 H40199

highest scoring ESTs for PAPPA:

AA156838 AA148534 AA004267 AA004406 AA029105 AA043911 AA046219 AA082581 AA085579 AA088178

Unigene Clusters for PAPPA:

Pregnancy-associated plasma protein A, pappalysin 1

Hs.643599 [show with all ESTs], Hs.713596 [show with all ESTs]

Unigene Representative Sequences: NM_002581, AY623011

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PAPPA (see all 9 )

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^
SP1:																							-						-																		-
SP2:													-		-		-		-		-		-						-
SP3:																													-
SP4:
SP5:

ExUns:	23	^	24	^	25	^	26
SP1:	-
SP2:
SP3:
SP4:	-
SP5:

About this scheme

ECgene alternative splicing isoforms for PAPPA

1 Ensembl transcript including schematic representation:

ENST00000328252

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAPPA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAPPA

¹ / ² / ³

21 probe-sets matching PAPPA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45332_r_at²^{, 3}	U95-B	2	1.00	0.50	0.63	1.21	AA156838	1.00	1.00	1.00	1
49040_at²^{, 3}	U95-C	1	0.94	1.00	0.54	0.81	AA148534	1.00	0.90	0.95	1
32549_at²^{, 3}	U95-A	1	0.81	1.00	0.42	0.13	U28727	0.80	1.00	0.91	1
232748_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU156721	0.60	1.00	0.82	1
224942_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BG434272	0.60	1.00	0.82	1
201981_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA148534	1.00	0.90	0.95	1
201982_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002581	0.60	1.00	0.82	1
228128_x_at²^{, 3}	U133-B	2	1.00	0.50	--	--	AI110886	0.60	1.00	0.82	1
224941_at²^{, 3}	U133-B	2	1.00	0.50	--	--	BF107618	0.40	1.00	0.76	1
224940_s_at²^{, 3}	U133-B	2	1.00	0.50	--	--	BF107618	0.40	1.00	0.76	1
232748_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558608_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558607_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224942_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201981_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1559400_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201982_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228128_x_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
224940_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
224941_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
1559928_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks PAPPA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATTTGTTTT

SOURCE GeneReport for Unigene clusters: Hs.643599 Hs.713596
Expression variation in blood from EXPOLDB for PAPPA
UniProtKB/Swiss-Prot: PAPP1_HUMAN, Q13219
Tissue specificity: High levels in placenta and pregnancy serum. In placenta, expressed in X cells
in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are
found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast,
prostate, bone marrow, colon, fibroblasts and osteoblasts

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAPPA gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAPPA¹	--	pregnancy-associated plasma protein A, pappalysin 1	89.7(n) 92.14(a)	481692 XM_538813.2 XP_538813.2
cow (Bos taurus)	PAPPA¹	--	pregnancy-associated plasma protein A, pappalysin 1	88.42(n) 89.75(a)	282647 XM_613511.3 XP_613511.3
rat (Rattus norvegicus)	Pappa¹	--	pregnancy-associated plasma protein A	88.73(n) 91.75(a)	313262 XM_233037.4 XP_233037.3
mouse (Mus musculus)	Pappa^{1, 5}	4 (32.20 cM)⁵	pregnancy-associated plasma protein A^{1, 5}	88.75(n)¹ 91.44(a)¹	18491¹ NM_021362.1¹ NP_067337.1¹ AF258461⁵ AF260433⁵ (see all 14)
chicken (Gallus gallus)	PAPPA¹	--	pregnancy-associated plasma protein A, pappalysin 1	78.1(n) 79.37(a)	417245 XM_415522.2 XP_415522.2

About this table Species with no ortholog for PAPPA

ENSEMBL Gene Tree for PAPPA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PAPPA gene

PAPPA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1304 NCBI SNPs in PAPPA are shown (see all 1304 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 523)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1054402^1,2	A,C,F,H	118203330(+)	`GATTAC/TGTCCT`	1	--	ut3¹ ese³		8	MN NA EU EA WA	744
	rs7020782^1,2	A,C,F,H	118146702(+)	`TGCTTA/CTCTCA`	1	S/Y	mis¹ ese³		9	EU EA WA NA	906
	rs3194846^1,2	A,C,F,H	118202366(+)	`TACAGA/CCTCAG`	1	--	ut3¹ ese³		5	MN EU EA WA	602
	rs3810940^1,2	A,C,F,H	118201074(+)	`GGTACA/GAGCTA`	1	--	ut3¹ ese³		10	EA NA EU WA	2240
	rs6478235^1,2	A,C,F,H	118199971(+)	`GGCTTC/TGATCC`	1	--	ut3¹ ese³		4	EU EA WA	420
--	rs10817885^1,2	A,C,F,H	118202888(+)	`TATAAT/CAGCCA`	1	--	ut3¹		7	NA EU EA WA	554
	rs2565^1,2	A,C,F,H	118200247(-)	`TGGGGG/TCTTCC`	1	--	ut3¹ ese³		7	MN EA EU WA	2254
	rs386088^1,2	A,C,F,H	117956014(+)	`AGGGGG/AAAAAT`	1	--	ut5¹ trp³		5	MN EU EA WA	596
	rs8653^1,2	A,C,F,H	118200569(-)	`CTATGA/CTAGAT`	1	--	ut3¹ ese³		17	MN NA EA EU WA	1658
	rs2296070^1,2	C,F,H	118198858(+)	`TTTACC/GCAGGA`	1	--	ut3¹ ese³		12	EA EU WA NA	2452

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HapMap Linkage Disequilibrium images for PAPPA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 176385

10/46 Novoseek disease relationships for PAPPA gene (see all 46 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome	93.05	253	16388509 (6), 7508624 (5), 18432600 (5), 9746387 (4) (see all 99)
trisomy	80.07	79	10416969 (6), 7528054 (5), 15906423 (4), 7526305 (3) (see all 28)
edwards syndrome	76.26	1	10360515 (1)
chromosomal aberrations	70.71	30	10820406 (3), 17278174 (2), 8863700 (2), 17154335 (2) (see all 22)
pregnancy complications	63.59	9	11028579 (3), 16086443 (2), 11038455 (1), 14663836 (1) (see all 5)
preeclampsia	62.41	67	18000943 (6), 12648442 (5), 16493628 (5), 19215554 (5) (see all 17)
stillbirth	56.28	12	16952214 (2), 14712947 (2), 15536112 (2), 16394054 (1) (see all 6)
spontaneous abortion	55.25	16	15305104 (3), 12224070 (3), 11028579 (2), 15533385 (1) (see all 9)
turners syndrome	53.83	4	10820406 (2), 19031473 (1), 16238533 (1)
preterm delivery	47.50	26	9516016 (4), 17962103 (3), 16219520 (3), 17992705 (3) (see all 11)

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(Possibly Related Articles in Doctor's Guide)
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Outcome Data Disputed in Abacavir/Lamivudine Comparison Trial: Presented at AIDS 2008

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/447 PubMed articles for PAPPA gene (see all 447 ):

Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. (PubMed id 7526035)^{1, 3, 4} Bonno M.... Gleich G.J. (1994)
Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. (PubMed id 11522292)^{1, 3, 4} Laursen L.S.... Oxvig C. (2001)
Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. (PubMed id 10913121)^{1, 3, 4} Overgaard M.T....Oxvig C. (2000)
Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites. (PubMed id 12421832)^{1, 3, 4} Overgaard M.T.... Oxvig C. (2003)
Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA. (PubMed id 7508748)^{1, 3, 4} Kristensen T.... Sottrup-Jensen L. (1994)
Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes. (PubMed id 7679961)^{1, 2, 3} Silahtaroglu A.N....Tommerup N. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene. (PubMed id 11822024)^{3, 4} Frosk P.... Wrogemann K. (2002)
The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. (PubMed id 10077652)^{3, 4} Lawrence J.B.... Conover C.A. (1999)
Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. (PubMed id 10491647)^{3, 4} Overgaard M.T.... Haaning J. (1999)

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Entrez Gene: 5069	HGNC: 8602	AceView: PAPPA	Ensembl:ENSG00000182752	euGenes: HUgn5069
ECgene: PAPPA	H-InvDB: PAPPA

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PAPPA	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PAPPA
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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Products for PAPPA:

TaqMan ® Gene Expression Assays

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PAPPA Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for PAPPA

Summaries
for PAPPA

Genomic Location
for PAPPA

Proteins
for PAPPA

Protein Domains/
Families
for PAPPA

Gene Function
for PAPPA

Pathways & Interactions
for PAPPA

Drugs & Compounds
for PAPPA

Transcripts
for PAPPA

Expression
for PAPPA

Orthologs
for PAPPA

Paralogs
for PAPPA

SNPs/Variants
for PAPPA

Disorders & Mutations
for PAPPA

Medical News
for PAPPA

Publications
for PAPPA

Search for PAPPA

Genome Databases showing PAPPA

Other Databases showing PAPPA

Specialized Databases showing PAPPA

Licensable Technologies
for PAPPA

Services
for PAPPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAPPA Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor PAPPA

Summariesfor PAPPA

Genomic Locationfor PAPPA

Proteinsfor PAPPA

Protein Domains/Familiesfor PAPPA

Gene Functionfor PAPPA

Pathways & Interactionsfor PAPPA

Drugs & Compoundsfor PAPPA

Transcriptsfor PAPPA

Expression for PAPPA

Orthologsfor PAPPA

Paralogsfor PAPPA

SNPs/Variantsfor PAPPA

Disorders & Mutationsfor PAPPA

Medical Newsfor PAPPA

Publicationsfor PAPPA

Search for PAPPA

Genome Databases showing PAPPA

Other Databases showing PAPPA

Specialized Databases showing PAPPA

Licensable Technologiesfor PAPPA

Servicesfor PAPPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAPPA

Summaries
for PAPPA

Genomic Location
for PAPPA

Proteins
for PAPPA

Protein Domains/
Families
for PAPPA

Gene Function
for PAPPA

Pathways & Interactions
for PAPPA

Drugs & Compounds
for PAPPA

Transcripts
for PAPPA

Expression
for PAPPA

Orthologs
for PAPPA

Paralogs
for PAPPA

SNPs/Variants
for PAPPA

Disorders & Mutations
for PAPPA

Medical News
for PAPPA

Publications
for PAPPA

Licensable Technologies
for PAPPA

Services
for PAPPA