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PAPOLG Gene

protein-coding   GIFtS: 55
GCID: GC02P060983

Poly(A) Polymerase Gamma

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly(A) Polymerase Gamma1 2     neo-PAP2
Neo-Poly(A) Polymerase2 3     Nuclear Poly(A) Polymerase Gamma2
Polynucleotide Adenylyltransferase Gamma2 3     SRP RNA 3' Adenylating Enzyme/Pap22
PAP-gamma2 3     Neo-PAP3
SRP RNA 3'-Adenylating Enzyme2 3     PAP23
EC 2.7.7.193 8     PAPG3

External Ids:    HGNC: 149821   Entrez Gene: 648952   Ensembl: ENSG000001154217   UniProtKB: Q9BWT33   

Export aliases for PAPOLG gene to outside databases

Previous GC identifers: GC02P061111 GC02P060941 GC02P060957 GC02P060895 GC02P060836 GC02P060725


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAPOLG Gene:
This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the
3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II
(PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional
domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and
polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome
2 in contrast to the PAPII gene, which is located on chromosome 14. (provided by RefSeq, Jul 2008)

GeneCards Summary for PAPOLG Gene:
PAPOLG (poly(A) polymerase gamma) is a protein-coding gene. Diseases associated with PAPOLG include crohn's disease, and hodgkin's lymphoma. GO annotations related to this gene include polynucleotide adenylyltransferase activity and RNA binding. An important paralog of this gene is PAPOLA.

UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3
Function: Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several
small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal
5S RNA

Gene Wiki entry for PAPOLG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAPOLG gene promoter:
         E2F-4   E2F-5   E2F-1   E2F   E2F-2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAPOLG promoter sequence
   Search Chromatin IP Primers for PAPOLG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAPOLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

PAPOLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAPOLG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P060983:  view genomic region     (about GC identifiers)

Start:
60,983,365 bp from pter      End:
61,029,221 bp from pter
Size:
45,857 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3 (See protein sequence)
Recommended Name: Poly(A) polymerase gamma  
Size: 736 amino acids; 82803 Da
Cofactor: Binds 2 magnesium ions. Also active with manganese (By similarity)
Sequence caution: Sequence=BAB14604.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for PAPOLG:
4LT6 (3D)    
Secondary accessions: B2RBH4 Q969N1 Q9H8L2 Q9HAD0

Explore the universe of human proteins at neXtProt for PAPOLG: NX_Q9BWT3

Explore proteomics data for PAPOLG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys109
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PAPOLG (Q9BWT3) (see all 10)
     WAMLVAR  CQLYPNA  KFFLVFS  SESKNLP 


    See PAPOLG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075045.2  
    ENSEMBL proteins: 
     ENSP00000238714   ENSP00000405599   ENSP00000414070   ENSP00000405570  

    PAPOLG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PAPOLG
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PAPOLG
    GenScript Custom Purified and Recombinant Proteins Services for PAPOLG
    Novus Biologicals PAPOLG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PAPOLG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PAPOLG
    Novus Biologicals PAPOLG Antibodies
    Abcam antibodies for PAPOLG
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for PAPOLG
    LSBio Antibodies in human, mouse, rat for PAPOLG

    PAPOLG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PAPOLG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR007012 PolA_pol_cen_dom
     IPR002934 Nucleotidyltransferase
     IPR007010 PolA_pol_RNA-bd_dom
     IPR014492 PolyA_polymerase
     IPR011068 NuclTrfase_I_C

    Graphical View of Domain Structure for InterPro Entry Q9BWT3

    ProtoNet protein and cluster: Q9BWT3

    2 Blocks protein domains:
    IPB002934 DNA polymerase
    IPB007012 Poly(A) polymerase


    UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3
    Similarity: Belongs to the poly(A) polymerase family


    PAPOLG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAPOG_HUMAN, Q9BWT3
    Function: Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several
    small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal
    5S RNA
    Catalytic activity: ATP + RNA(n) = diphosphate + RNA(n+1)

         Enzyme Number (IUBMB): EC 2.7.7.191 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004652polynucleotide adenylyltransferase activity IDA11463842
    GO:0005524ATP binding IEA--
    GO:0016779nucleotidyltransferase activity ----
    GO:0046872metal ion binding IDA--
         
    PAPOLG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PAPOLG:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAPOLG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAPOLG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAPOLG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAPOLG

    miRNA
    Products:
        
    miRTarBase miRNAs that target PAPOLG:
    hsa-mir-33a-5p (MIRT028237), hsa-mir-16-5p (MIRT031918)

    Block miRNA regulation of human, mouse, rat PAPOLG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAPOLG (see all 151):
    hsa-miR-411* hsa-miR-579 hsa-miR-3653 hsa-miR-200b hsa-miR-3612 hsa-miR-30b* hsa-miR-455-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPAPOLG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PAPOLG
    Predesigned siRNA for gene silencing in human, mouse, rat PAPOLG

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PAPOLG

    Clone
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    OriGene clones in human, mouse for PAPOLG (see all 8)
    OriGene ORF clones in mouse, rat for PAPOLG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PAPOLG (NM_022894)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAPOLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAPOLG

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PAPOLG
    Browse ESI BIO Cell Lines and PureStem Progenitors for PAPOLG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPOLG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAPOG_HUMAN, Q9BWT3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    PAPOLG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAPOLG About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for PAPOLG):
        mRNA surveillance pathway


    PAPOLG for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAPOLG
    Interactions:

        Search GeneGlobe Interaction Network for PAPOLG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAPOLG (Q9BWT33 ENSP000002387144) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBD1P614573, ENSP000002992994I2D: score=1 STRING: ENSP00000299299
    LZTR1Q8N6533, ENSP000002157394I2D: score=1 STRING: ENSP00000215739
    NFYAP235113, ENSP000003457024I2D: score=1 STRING: ENSP00000345702
    FIP1L1ENSP000003367524STRING: ENSP00000336752
    CPSF2ENSP000002988754STRING: ENSP00000298875
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IBA--
    GO:0031123RNA 3'-end processing ----
    GO:0043631RNA polyadenylation IDA11287430

    PAPOLG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAPOLG (PAPOG)

    3 HMDB Compounds for PAPOLG    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PAPOLG gene: 
    NM_022894.3  

    Unigene Cluster for PAPOLG:

    Poly(A) polymerase gamma
    Hs.387471  [show with all ESTs]
    Unigene Representative Sequence: NM_022894
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238714 ENST00000496283 ENST00000414060 ENST00000453839 ENST00000483370
    ENST00000412217(uc002sai.3 uc002saj.3 uc002sak.3 uc010fch.3)
    ENST00000470208
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PAPOLG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAPOLG (see all 151):
    hsa-miR-411* hsa-miR-579 hsa-miR-3653 hsa-miR-200b hsa-miR-3612 hsa-miR-30b* hsa-miR-455-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPAPOLG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PAPOLG
    Predesigned siRNA for gene silencing in human, mouse, rat PAPOLG
    Clone
    Products:
         
    OriGene clones in human, mouse for PAPOLG (see all 8)
    OriGene ORF clones in mouse, rat for PAPOLG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PAPOLG (NM_022894)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAPOLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAPOLG
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PAPOLG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAPOLG
      QuantiTect SYBR Green Assays in human, mouse, rat PAPOLG
      QuantiFast Probe-based Assays in human, mouse, rat PAPOLG

    Additional mRNA sequence: 

    AB209304.1 AF075029.1 AF312211.1 AJ308101.1 AK021867.1 AK023034.1 AK023544.1 AK024249.1 
    AK314663.1 AY029162.1 BC016738.1 BC028593.2 BC068493.1 BC110906.1 BC111701.1 BC113747.1 
    BX647824.1 

    9 DOTS entries:

    DT.440367  DT.108261  DT.97764195  DT.92426087  DT.91977037  DT.40120101  DT.100751014  DT.95369399 
    DT.95151734 

    Selected AceView cDNA sequences (see all 80):

    AI694611 AJ308101 BC028593 AI690023 AU129635 AK021867 BU732858 AI480041 
    AF312211 BM692821 CF541139 AU119633 AK023544 BG498675 AI279419 BQ229755 
    AA461432 AI926507 AW504644 AL708655 AI872488 NM_022894 BU674687 AK023034 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PAPOLG (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
    SP1:                                                                                                                    -                                   -   
    SP2:                                                                                                                                                            
    SP3:              -     -                                                                                                                                       
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 18b ^ 19 ^ 20a · 20b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PAPOLG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAPOLG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PAPOLG Expression
    About this image

    PAPOLG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAPOLG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387471

    UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3
    Tissue specificity: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several
    tumors

        Custom PCR Arrays for PAPOLG
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAPOLG
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    QuantiFast Probe-based Assays in human, mouse, rat PAPOLG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPOLG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PAPOLG gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Papolg1 , 5 poly(A) polymerase gamma1, 5 91.64(n)1
    94.55(a)1
      11 (14.37 cM)5
    2165781  NM_172555.21  NP_766143.21 
     238626465 
    chicken
    (Gallus gallus)
    Aves PAPOLG1 poly(A) polymerase gamma 73.48(n)
    73.66(a)
      100857196  XM_003640881.2  XP_003640929.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    63(a)
    56(a)
    1 ↔ many
    1 ↔ many
    1(259426924-259457906)
    1(259415946-259420058)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420228072   -- 78.79(n)    142022807 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637622 hypothetical protein MGC63762 76.21(n)   393593  BC056818.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hrg1 , 3 mRNA polyadenylation polynucleotide
    adenylyltransferase3
    hiiragi1
    55(a)3
    58.07(n)1
    61.51(a)1
      56E33
    496361  NM_001043097.21  NP_001036562.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T15H9.63 poly(A) polymerase 45(a)
    (best of 2)
      II(9607641-9609305)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PAP1(YKR002W)4
    PAP11
    Poly(A) polymerase, one of three factors required for more4
    PAP11
    54.64(n)1
    46.87(a)1
      11(443232-444938)4
    8538711, 4  NP_012927.31  NP_012927.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PAPS11 PAPS1 50.57(n)
    43.64(a)
      838378  NM_101661.4  NP_173240.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g03196001 Os06g0319600 52.94(n)
    46.85(a)
      4340886  NM_001064042.2  NP_001057507.2 


    ENSEMBL Gene Tree for PAPOLG (if available)
    TreeFam Gene Tree for PAPOLG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAPOLG gene
    PAPOLA2  PAPOLB2  
    3 SIMAP similar genes for PAPOLG using alignment to 8 protein entries:     PAPOG_HUMAN (see all proteins):
    PAPOLB    PAPOLA    TPAP

    PAPOLG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAPOLG (see all 986)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830316601,2
    --60981641(+) CTTGGC/TTGGGT 1 -- us2k10--------
    rs1876564291,2
    --60981652(+) GTGGTA/GGCTCA 1 -- us2k10--------
    rs778279161,2
    C--60981696(+) TGGGCA/GGATTA 1 -- us2k10--------
    rs621493751,2
    C,F--60981709(+) TGATGT/ACAGGA 1 -- us2k15Minor allele frequency- A:0.23NA WA EA 362
    rs67611321,2
    C--60981888(+) aacctC/Ttgcct 1 -- us2k13Minor allele frequency- T:0.24NA WA 240
    rs76089651,2
    C,F,A--60981897(+) ctctcG/Aggttc 1 -- us2k19Minor allele frequency- A:0.26NA WA CSA EA 369
    rs751695891,2
    C--60981971(-) ATACAA/GAAAAC 1 -- us2k13Minor allele frequency- G:0.17NA 6
    rs753212221,2
    C--60981984(+) TTAGTA/TGAGAC 1 -- us2k13Minor allele frequency- T:0.00NA 6
    rs772231431,2
    F--60982021(+) GCCTCG/AAACTC 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs65458311,2
    C,F,H--60982103(+) gccACG/ATCAGG 1 -- us2k1 tfbs327Minor allele frequency- A:0.44NS EA NA WA CSA 2769

    HapMap Linkage Disequilibrium report for PAPOLG (60983365 - 61029221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PAPOLG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834215CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PAPOLG
    DNA2.0 Custom Variant and Variant Library Synthesis for PAPOLG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for PAPOLG:    
    About MalaCards
    crohn's disease    hodgkin's lymphoma


    PAPOLG for disorders           About GeneDecksing

    Genetic Association Database (GAD): PAPOLG

    Export disorders for PAPOLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAPOLG gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PAPOLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases. (PubMed id 24076191)1, 2 Yang Q....DoubliAc S. (J. Mol. Biol. 2014)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors. (PubMed id 11463842)1, 2 Topalian S.L....Manley J.L. (Mol. Cell. Biol. 2001)
    5. Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme. (PubMed id 11287430)1, 2 Perumal K.... Reddy R. (J. Biol. Chem. 2001)
    6. A novel nuclear human poly(A) polymerase (PAP), PAP gamma. (PubMed id 11431479)1, 9 Kyriakopoulou C.B....Virtanen A. (J. Biol. Chem. 2001)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (PLoS Genet. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length. (PubMed id 21822216)1 Sagawa F....Wilusz J. (EMBO J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64895 HGNC: 14982 AceView: PAPOLG Ensembl:ENSG00000115421 euGenes: HUgn64895
    ECgene: PAPOLG Kegg: 64895 H-InvDB: PAPOLG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAPOLG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAPOLG gene:
    Search GeneIP for patents involving PAPOLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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