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Aliases for PAPOLG Gene

Aliases for PAPOLG Gene

  • Poly(A) Polymerase Gamma 2 3 5
  • Polynucleotide Adenylyltransferase Gamma 3 4
  • SRP RNA 3-Adenylating Enzyme 3 4
  • Neo-Poly(A) Polymerase 3 4
  • EC 2.7.7.19 4 63
  • PAP-Gamma 3 4
  • Neo-PAP 3 4
  • SRP RNA 3 Adenylating Enzyme/Pap2 3
  • Nuclear Poly(A) Polymerase Gamma 3
  • PAP2 4
  • PAPG 4

External Ids for PAPOLG Gene

Previous GeneCards Identifiers for PAPOLG Gene

  • GC02P061111
  • GC02P060941
  • GC02P060957
  • GC02P060895
  • GC02P060836
  • GC02P060983
  • GC02P060725

Summaries for PAPOLG Gene

Entrez Gene Summary for PAPOLG Gene

  • This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAPOLG Gene

PAPOLG (Poly(A) Polymerase Gamma) is a Protein Coding gene. Diseases associated with PAPOLG include acute cystitis and bladder disease. Among its related pathways are mRNA surveillance pathway. GO annotations related to this gene include RNA binding and polynucleotide adenylyltransferase activity. An important paralog of this gene is PAPOLB.

UniProtKB/Swiss-Prot for PAPOLG Gene

  • Responsible for the post-transcriptional adenylation of the 3-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.

Gene Wiki entry for PAPOLG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPOLG Gene

Genomics for PAPOLG Gene

Regulatory Elements for PAPOLG Gene

Enhancers for PAPOLG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAPOLG on UCSC Golden Path with GeneCards custom track

Promoters for PAPOLG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAPOLG on UCSC Golden Path with GeneCards custom track

Genomic Location for PAPOLG Gene

Chromosome:
2
Start:
60,756,230 bp from pter
End:
60,802,086 bp from pter
Size:
45,857 bases
Orientation:
Plus strand

Genomic View for PAPOLG Gene

Genes around PAPOLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAPOLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAPOLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPOLG Gene

Proteins for PAPOLG Gene

  • Protein details for PAPOLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWT3-PAPOG_HUMAN
    Recommended name:
    Poly(A) polymerase gamma
    Protein Accession:
    Q9BWT3
    Secondary Accessions:
    • B2RBH4
    • Q59G05
    • Q969N1
    • Q9H8L2
    • Q9HAD0

    Protein attributes for PAPOLG Gene

    Size:
    736 amino acids
    Molecular mass:
    82803 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14604.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAPOLG Gene

    Alternative splice isoforms for PAPOLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAPOLG Gene

Proteomics data for PAPOLG Gene at MOPED

Post-translational modifications for PAPOLG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAPOLG Gene

Antibody Products

Domains & Families for PAPOLG Gene

Suggested Antigen Peptide Sequences for PAPOLG Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWT3

UniProtKB/Swiss-Prot:

PAPOG_HUMAN :
  • Belongs to the poly(A) polymerase family.
Family:
  • Belongs to the poly(A) polymerase family.
genes like me logo Genes that share domains with PAPOLG: view

No data available for Gene Families for PAPOLG Gene

Function for PAPOLG Gene

Molecular function for PAPOLG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
Responsible for the post-transcriptional adenylation of the 3-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.

Enzyme Numbers (IUBMB) for PAPOLG Gene

Gene Ontology (GO) - Molecular Function for PAPOLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004652 polynucleotide adenylyltransferase activity IEA,IDA 11463842
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with PAPOLG: view
genes like me logo Genes that share phenotypes with PAPOLG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PAPOLG

miRNA for PAPOLG Gene

miRTarBase miRNAs that target PAPOLG

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAPOLG Gene

Localization for PAPOLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAPOLG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAPOLG Gene COMPARTMENTS Subcellular localization image for PAPOLG gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PAPOLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PAPOLG: view

Pathways & Interactions for PAPOLG Gene

SuperPathways for PAPOLG Gene

Superpath Contained pathways
1 mRNA surveillance pathway
genes like me logo Genes that share pathways with PAPOLG: view

Pathways by source for PAPOLG Gene

1 KEGG pathway for PAPOLG Gene

Gene Ontology (GO) - Biological Process for PAPOLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031123 RNA 3-end processing IEA --
GO:0043631 RNA polyadenylation IEA,IDA 11287430
genes like me logo Genes that share ontologies with PAPOLG: view

No data available for SIGNOR curated interactions for PAPOLG Gene

Drugs & Compounds for PAPOLG Gene

(2) Drugs for PAPOLG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for PAPOLG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with PAPOLG: view

Transcripts for PAPOLG Gene

Unigene Clusters for PAPOLG Gene

Poly(A) polymerase gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAPOLG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - -
SP2:
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:

ExUns: 18b ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PAPOLG Gene

GeneLoc Exon Structure for
PAPOLG
ECgene alternative splicing isoforms for
PAPOLG

Expression for PAPOLG Gene

mRNA expression in normal human tissues for PAPOLG Gene

Protein differential expression in normal tissues from HIPED for PAPOLG Gene

This gene is overexpressed in Pancreatic juice (40.1), Adipocyte (10.8), and Testis (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAPOLG Gene



SOURCE GeneReport for Unigene cluster for PAPOLG Gene Hs.387471

mRNA Expression by UniProt/SwissProt for PAPOLG Gene

Q9BWT3-PAPOG_HUMAN
Tissue specificity: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors.
genes like me logo Genes that share expression patterns with PAPOLG: view

Protein tissue co-expression partners for PAPOLG Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PAPOLG Gene

Orthologs for PAPOLG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PAPOLG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAPOLG 35
  • 93.2 (n)
  • 95.37 (a)
PAPOLG 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAPOLG 35
  • 93.86 (n)
  • 95.5 (a)
PAPOLG 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Papolg 35
  • 91.64 (n)
  • 94.55 (a)
Papolg 16
Papolg 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAPOLG 35
  • 99.77 (n)
  • 100 (a)
PAPOLG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Papolg 35
  • 89.96 (n)
  • 94.01 (a)
oppossum
(Monodelphis domestica)
Mammalia PAPOLG 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAPOLG 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAPOLG 35
  • 73.48 (n)
  • 73.66 (a)
PAPOLG 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia papolg 35
  • 72.47 (n)
  • 76.87 (a)
zebrafish
(Danio rerio)
Actinopterygii papolg 35
  • 70.17 (n)
  • 77.07 (a)
zgc63762 35
papolg 36
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6689 35
fruit fly
(Drosophila melanogaster)
Insecta hrg 37
  • 55 (a)
hrg 35
  • 58.07 (n)
  • 61.51 (a)
hrg 36
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013207 35
  • 59.37 (n)
  • 63.45 (a)
worm
(Caenorhabditis elegans)
Secernentea T15H9.6 37
  • 45 (a)
Y32F6A.3 37
  • 43 (a)
F43G6.5 36
  • 43 (a)
ManyToMany
pap-1 36
  • 38 (a)
ManyToMany
T15H9.6 36
  • 42 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL002C 35
  • 49.29 (n)
  • 46.68 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13255g 35
  • 54.22 (n)
  • 45.39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAP1 35
  • 54.64 (n)
  • 46.87 (a)
PAP1 36
  • 38 (a)
OneToMany
PAP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PAPS1 35
  • 50.57 (n)
  • 43.64 (a)
rice
(Oryza sativa)
Liliopsida Os06g0319600 35
  • 52.94 (n)
  • 46.85 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08983 35
  • 48.07 (n)
  • 43.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pla1 35
  • 53.69 (n)
  • 46.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2725 36
  • 64 (a)
OneToMany
Species with no ortholog for PAPOLG:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAPOLG Gene

ENSEMBL:
Gene Tree for PAPOLG (if available)
TreeFam:
Gene Tree for PAPOLG (if available)

Paralogs for PAPOLG Gene

Paralogs for PAPOLG Gene

(3) SIMAP similar genes for PAPOLG Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PAPOLG: view

Variants for PAPOLG Gene

Sequence variations from dbSNP and Humsavar for PAPOLG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1821183 -- 60,776,368(-) AGAAT(C/G)ATGCT intron-variant
rs2017164 -- 60,801,592(+) GCGCC(A/C)GCCAC utr-variant-3-prime
rs3196891 -- 60,798,214(+) ACCAA(C/T)CATTA utr-variant-3-prime
rs2083154 -- 60,756,976(+) CCGCC(A/G)TCCCC intron-variant
rs2099613 -- 60,756,834(+) CTGCT(C/T)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAPOLG Gene

Variant ID Type Subtype PubMed ID
nsv834215 CNV Loss 17160897

Variation tolerance for PAPOLG Gene

Residual Variation Intolerance Score: 3.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAPOLG Gene

HapMap Linkage Disequilibrium report
PAPOLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPOLG Gene

Disorders for PAPOLG Gene

MalaCards: The human disease database

(3) MalaCards diseases for PAPOLG Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute cystitis
  • urinary tract infection
bladder disease
  • urinary bladder disease
chromosome 2p16.1-p15 deletion syndrome
  • 2p15-p16.1 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PAPOLG

Genetic Association Database (GAD)
PAPOLG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAPOLG
genes like me logo Genes that share disorders with PAPOLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAPOLG Gene

Publications for PAPOLG Gene

  1. Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases. (PMID: 24076191) Yang Q. … DoubliAc S. (J. Mol. Biol. 2014) 3 4 67
  2. A novel nuclear human poly(A) polymerase (PAP), PAP gamma. (PMID: 11431479) Kyriakopoulou C.B. … Virtanen A. (J. Biol. Chem. 2001) 3 23
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for PAPOLG Gene

Sources for PAPOLG Gene

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