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Aliases for PAPOLG Gene

Aliases for PAPOLG Gene

  • Poly(A) Polymerase Gamma 2 3
  • Polynucleotide Adenylyltransferase Gamma 3 4
  • SRP RNA 3-Adenylating Enzyme 3 4
  • Neo-Poly(A) Polymerase 3 4
  • EC 4 63
  • PAP-Gamma 3 4
  • Neo-PAP 3 4
  • SRP RNA 3 Adenylating Enzyme/Pap2 3
  • Nuclear Poly(A) Polymerase Gamma 3
  • PAP2 4
  • PAPG 4

External Ids for PAPOLG Gene

Previous GeneCards Identifiers for PAPOLG Gene

  • GC02P061111
  • GC02P060941
  • GC02P060957
  • GC02P060895
  • GC02P060836
  • GC02P060983
  • GC02P060725

Summaries for PAPOLG Gene

Entrez Gene Summary for PAPOLG Gene

  • This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAPOLG Gene

PAPOLG (Poly(A) Polymerase Gamma) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway. GO annotations related to this gene include RNA binding and polynucleotide adenylyltransferase activity. An important paralog of this gene is PAPOLB.

UniProtKB/Swiss-Prot for PAPOLG Gene

  • Responsible for the post-transcriptional adenylation of the 3-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.

Gene Wiki entry for PAPOLG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPOLG Gene

Genomics for PAPOLG Gene

Regulatory Elements for PAPOLG Gene

Genomic Location for PAPOLG Gene

60,756,230 bp from pter
60,802,086 bp from pter
45,857 bases
Plus strand

Genomic View for PAPOLG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAPOLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPOLG Gene

Proteins for PAPOLG Gene

  • Protein details for PAPOLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly(A) polymerase gamma
    Protein Accession:
    Secondary Accessions:
    • B2RBH4
    • Q59G05
    • Q969N1
    • Q9H8L2
    • Q9HAD0

    Protein attributes for PAPOLG Gene

    736 amino acids
    Molecular mass:
    82803 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium ions. Also active with manganese.;
    Quaternary structure:
    No Data Available
    • Sequence=BAB14604.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAPOLG Gene

    Alternative splice isoforms for PAPOLG Gene


neXtProt entry for PAPOLG Gene

Proteomics data for PAPOLG Gene at MOPED

Post-translational modifications for PAPOLG Gene

  • Ubiquitination at Lys109
  • Modification sites at PhosphoSitePlus

Other Protein References for PAPOLG Gene

Domains for PAPOLG Gene

Suggested Antigen Peptide Sequences for PAPOLG Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BWT3
  • Belongs to the poly(A) polymerase family.
genes like me logo Genes that share domains with PAPOLG: view

No data available for Gene Families for PAPOLG Gene

Function for PAPOLG Gene

Molecular function for PAPOLG Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function: Responsible for the post-transcriptional adenylation of the 3-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.

Enzyme Numbers (IUBMB) for PAPOLG Gene

Gene Ontology (GO) - Molecular Function for PAPOLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004652 polynucleotide adenylyltransferase activity IDA 11463842
GO:0005524 ATP binding IEA --
GO:0016779 nucleotidyltransferase activity --
GO:0046872 metal ion binding IDA 24076191
genes like me logo Genes that share ontologies with PAPOLG: view

Phenotypes for PAPOLG Gene

GenomeRNAi human phenotypes for PAPOLG:
genes like me logo Genes that share phenotypes with PAPOLG: view

miRNA for PAPOLG Gene

miRTarBase miRNAs that target PAPOLG

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PAPOLG Gene

Localization for PAPOLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAPOLG Gene

Subcellular locations from

Jensen Localization Image for PAPOLG Gene COMPARTMENTS Subcellular localization image for PAPOLG gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for PAPOLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PAPOLG: view

Pathways for PAPOLG Gene

SuperPathways for PAPOLG Gene

Superpath Contained pathways
1 mRNA surveillance pathway
genes like me logo Genes that share pathways with PAPOLG: view

Pathways by source for PAPOLG Gene

1 KEGG pathway for PAPOLG Gene

Gene Ontology (GO) - Biological Process for PAPOLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IBA --
GO:0031123 RNA 3-end processing --
GO:0043631 RNA polyadenylation IDA 11287430
genes like me logo Genes that share ontologies with PAPOLG: view

Compounds for PAPOLG Gene

(3) HMDB Compounds for PAPOLG Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with PAPOLG: view

Transcripts for PAPOLG Gene

Unigene Clusters for PAPOLG Gene

Poly(A) polymerase gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAPOLG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - -
SP3: - -
SP4: -
SP6: - -

ExUns: 18b ^ 19 ^ 20a · 20b

Relevant External Links for PAPOLG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAPOLG Gene

mRNA expression in normal human tissues for PAPOLG Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAPOLG Gene

SOURCE GeneReport for Unigene cluster for PAPOLG Gene Hs.387471

mRNA Expression by UniProt/SwissProt for PAPOLG Gene

Tissue specificity: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors.
genes like me logo Genes that share expressions with PAPOLG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PAPOLG Gene

Orthologs for PAPOLG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PAPOLG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PAPOLG 35
  • 99.77 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia PAPOLG 35
  • 93.2 (n)
  • 95.37 (a)
  • 94 (a)
(Canis familiaris)
Mammalia PAPOLG 35
  • 93.86 (n)
  • 95.5 (a)
  • 90 (a)
(Mus musculus)
Mammalia Papolg 35
  • 91.64 (n)
  • 94.55 (a)
Papolg 16
Papolg 36
  • 94 (a)
(Monodelphis domestica)
Mammalia PAPOLG 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia PAPOLG 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Papolg 35
  • 89.96 (n)
  • 94.01 (a)
(Gallus gallus)
Aves PAPOLG 35
  • 73.48 (n)
  • 73.66 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
-- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia papolg 35
  • 72.47 (n)
  • 76.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6689 35
(Danio rerio)
Actinopterygii papolg 35
  • 70.17 (n)
  • 77.07 (a)
papolg 36
  • 73 (a)
zgc63762 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013207 35
  • 59.37 (n)
  • 63.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta hrg 35
  • 58.07 (n)
  • 61.51 (a)
hrg 36
  • 48 (a)
hrg 37
  • 55 (a)
(Caenorhabditis elegans)
Secernentea F43G6.5 36
  • 43 (a)
pap-1 36
  • 38 (a)
T15H9.6 36
  • 42 (a)
T15H9.6 37
  • 45 (a)
Y32F6A.3 37
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL002C 35
  • 49.29 (n)
  • 46.68 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAP1 35
  • 54.64 (n)
  • 46.87 (a)
PAP1 36
  • 38 (a)
PAP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13255g 35
  • 54.22 (n)
  • 45.39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PAPS1 35
  • 50.57 (n)
  • 43.64 (a)
(Oryza sativa)
Liliopsida Os06g0319600 35
  • 52.94 (n)
  • 46.85 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08983 35
  • 48.07 (n)
  • 43.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pla1 35
  • 53.69 (n)
  • 46.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2725 36
  • 64 (a)
Species with no ortholog for PAPOLG:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAPOLG Gene

Gene Tree for PAPOLG (if available)
Gene Tree for PAPOLG (if available)

Paralogs for PAPOLG Gene

Paralogs for PAPOLG Gene

Selected SIMAP similar genes for PAPOLG Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PAPOLG: view

Variants for PAPOLG Gene

Sequence variations from dbSNP and Humsavar for PAPOLG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1177165 -- 60,776,563(-) gtaat(C/T)ccagc intron-variant
rs1177166 -- 60,776,456(-) agtga(A/G)actcc intron-variant
rs1177167 -- 60,776,450(-) actcc(A/G)tctca intron-variant
rs1177168 -- 60,758,533(-) ggaga(A/T)tcgct intron-variant
rs1177169 -- 60,758,488(-) atcgc(A/G)ccacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAPOLG Gene

Variant ID Type Subtype PubMed ID
nsv834215 CNV Loss 17160897

Relevant External Links for PAPOLG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPOLG Gene

Disorders for PAPOLG Gene

Relevant External Links for PAPOLG

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PAPOLG: view

No data available for UniProtKB/Swiss-Prot for PAPOLG Gene

Publications for PAPOLG Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases. (PMID: 24076191) Yang Q. … DoubliAc S. (J. Mol. Biol. 2014) 3 4
  3. A novel nuclear human poly(A) polymerase (PAP), PAP gamma. (PMID: 11431479) Kyriakopoulou C.B. … Virtanen A. (J. Biol. Chem. 2001) 3 23
  4. Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme. (PMID: 11287430) Perumal K. … Reddy R. (J. Biol. Chem. 2001) 3 4
  5. Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors. (PMID: 11463842) Topalian S.L. … Manley J.L. (Mol. Cell. Biol. 2001) 3 4

Products for PAPOLG Gene

Sources for PAPOLG Gene

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