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Aliases for PAPLN Gene

Aliases for PAPLN Gene

  • Papilin, Proteoglycan Like Sulfated Glycoprotein 2 3 5
  • Papilin 3

External Ids for PAPLN Gene

Previous GeneCards Identifiers for PAPLN Gene

  • GC14P071694
  • GC14P071696
  • GC14P072774
  • GC14P073704
  • GC14P053869

Summaries for PAPLN Gene

GeneCards Summary for PAPLN Gene

PAPLN (Papilin, Proteoglycan Like Sulfated Glycoprotein) is a Protein Coding gene. GO annotations related to this gene include peptidase activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is ADAMTSL1.

Gene Wiki entry for PAPLN Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPLN Gene

Genomics for PAPLN Gene

Regulatory Elements for PAPLN Gene

Enhancers for PAPLN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F073178 1.2 VISTA Ensembl ENCODE 18.1 -55.3 -55329 3.5 MAZ HLF FOXA3 GTF2E2 CEBPB CEBPG EP300 RAD21 NR2F2 YY1 PAPLN LOC100420966 ELMSAN1 RBM25 PSEN1 RNU6-419P NUMB LOC101928123 ENSG00000259109
GH14F073240 1 Ensembl ENCODE 19.5 +6.3 6258 3.0 CDC5L ZNF121 ZNF316 ZFHX2 FOXK2 SCRT2 EED NFE2 ZSCAN29 EGR2 LOC101928123 PAPLN PSEN1 DCAF4
GH14F073296 1 ENCODE 10.9 +60.8 60803 1.7 HDGF ATF1 PKNOX1 ARID4B SIN3A YY1 SLC30A9 SP5 NFYC JUNB NUMB RNU6-419P LOC105370561 PAPLN PTGR2 ENSG00000223300 ENSG00000258944 GC14P073395
GH14F073287 1 ENCODE 10.7 +51.6 51582 0.7 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF48 GATA2 SP5 JUNB MIER2 RNU6-419P PAPLN NUMB ENSG00000258944 GC14P073395
GH14F073057 1.1 ENCODE 9.7 -177.2 -177219 3.0 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS LOC101928123 RBM25 ZFYVE1 ELMSAN1 PAPLN DCAF4 PSEN1 ACOT1 LOC105370560
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAPLN on UCSC Golden Path with GeneCards custom track

Genomic Location for PAPLN Gene

Chromosome:
14
Start:
73,235,843 bp from pter
End:
73,274,640 bp from pter
Size:
38,798 bases
Orientation:
Plus strand

Genomic View for PAPLN Gene

Genes around PAPLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAPLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAPLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPLN Gene

Proteins for PAPLN Gene

  • Protein details for PAPLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95428-PPN_HUMAN
    Recommended name:
    Papilin
    Protein Accession:
    O95428
    Secondary Accessions:
    • B4DES8
    • B4DGE6
    • Q659F2
    • Q6UXJ4
    • Q6ZNM1
    • Q6ZUJ0
    • Q7Z681
    • Q8IVU0

    Protein attributes for PAPLN Gene

    Size:
    1278 amino acids
    Molecular mass:
    137700 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC97963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC86235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG57189.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57189.1; Type=Erroneous termination; Positions=1216; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAG57757.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH56406.1; Type=Miscellaneous discrepancy; Note=Partially unspliced mRNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for PAPLN Gene

neXtProt entry for PAPLN Gene

Post-translational modifications for PAPLN Gene

  • Glycosylation at Ser 701, Thr 702, Thr 706, Thr 872, Ser 897, Ser 1221, and Thr 1225
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAPLN Gene

Domains & Families for PAPLN Gene

Gene Families for PAPLN Gene

Suggested Antigen Peptide Sequences for PAPLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95428

UniProtKB/Swiss-Prot:

PPN_HUMAN :
  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Belongs to the papilin family.
Domain:
  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 PLAC domain.
  • Contains 5 TSP type-1 domains.
Family:
  • Belongs to the papilin family.
genes like me logo Genes that share domains with PAPLN: view

Function for PAPLN Gene

Gene Ontology (GO) - Molecular Function for PAPLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PAPLN: view
genes like me logo Genes that share phenotypes with PAPLN: view

Animal Models for PAPLN Gene

MGI Knock Outs for PAPLN:

Animal Model Products

  • Taconic Biosciences Mouse Models for PAPLN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAPLN Gene

Localization for PAPLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAPLN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAPLN gene
Compartment Confidence
extracellular 4
plasma membrane 3
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PAPLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with PAPLN: view

Pathways & Interactions for PAPLN Gene

SuperPathways for PAPLN Gene

No Data Available

Interacting Proteins for PAPLN Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345395%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000368190%0d%0a9606.ENSP00000201031%0d%0a9606.ENSP00000424243%0d%0a9606.ENSP00000346964%0d%0a
Selected Interacting proteins: O95428-PPN_HUMAN ENSP00000345395 for PAPLN Gene via IID STRING

Gene Ontology (GO) - Biological Process for PAPLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PAPLN: view

No data available for Pathways by source and SIGNOR curated interactions for PAPLN Gene

Drugs & Compounds for PAPLN Gene

(1) Drugs for PAPLN Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 503
genes like me logo Genes that share compounds with PAPLN: view

Transcripts for PAPLN Gene

Unigene Clusters for PAPLN Gene

Papilin, proteoglycan-like sulfated glycoprotein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAPLN Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6: - - -
SP7:
SP8:

Relevant External Links for PAPLN Gene

GeneLoc Exon Structure for
PAPLN
ECgene alternative splicing isoforms for
PAPLN

Expression for PAPLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAPLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAPLN Gene

This gene is overexpressed in Nerve - Tibial (x4.7).

Protein differential expression in normal tissues from HIPED for PAPLN Gene

This gene is overexpressed in Skin (20.8), Serum (14.9), and Amniocyte (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAPLN Gene



NURSA nuclear receptor signaling pathways regulating expression of PAPLN Gene:

PAPLN

SOURCE GeneReport for Unigene cluster for PAPLN Gene:

Hs.509909
genes like me logo Genes that share expression patterns with PAPLN: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PAPLN Gene

Orthologs for PAPLN Gene

This gene was present in the common ancestor of animals.

Orthologs for PAPLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAPLN 34 35
  • 96.4 (n)
dog
(Canis familiaris)
Mammalia PAPLN 34
  • 81.92 (n)
-- 35
  • 76 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Papln 34 16 35
  • 79.02 (n)
rat
(Rattus norvegicus)
Mammalia Papln 34
  • 78.71 (n)
cow
(Bos Taurus)
Mammalia PAPLN 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAPLN 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PAPLN 34 35
  • 60.27 (n)
lizard
(Anolis carolinensis)
Reptilia PAPLN 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia papln 34
  • 56.28 (n)
zebrafish
(Danio rerio)
Actinopterygii papln 34
  • 54.68 (n)
paplna 35
  • 42 (a)
OneToMany
paplnb 35
  • 41 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001662 34
  • 49.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ppn 34 35
  • 47.42 (n)
worm
(Caenorhabditis elegans)
Secernentea mig-6 35
  • 16 (a)
OneToOne
Species where no ortholog for PAPLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAPLN Gene

ENSEMBL:
Gene Tree for PAPLN (if available)
TreeFam:
Gene Tree for PAPLN (if available)

Paralogs for PAPLN Gene

genes like me logo Genes that share paralogs with PAPLN: view

Variants for PAPLN Gene

Sequence variations from dbSNP and Humsavar for PAPLN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1003647 -- 73,246,003(-) CCGCC(C/G)GAGCC intron-variant, upstream-variant-2KB
rs1005013 -- 73,252,570(-) atcct(A/G)cactc intron-variant
rs1005014 -- 73,252,218(-) GAGGG(C/T)TGTGA intron-variant
rs1008245 -- 73,243,988(+) ggagg(A/C)aggag intron-variant, upstream-variant-2KB
rs10139009 -- 73,233,846(+) GAGAG(A/T)TCTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PAPLN Gene

Variant ID Type Subtype PubMed ID
dgv1932n100 CNV gain 25217958
dgv1933n100 CNV gain 25217958
dgv1934n100 CNV loss 25217958
esv33062 CNV gain 17666407
nsv1035460 CNV gain 25217958
nsv1038340 CNV gain+loss 25217958
nsv1041358 CNV gain 25217958
nsv1042100 CNV loss 25217958
nsv516851 CNV loss 19592680
nsv85407 CNV deletion 16902084
nsv85914 CNV deletion 16902084

Variation tolerance for PAPLN Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.80; 96.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAPLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAPLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPLN Gene

Disorders for PAPLN Gene

Relevant External Links for PAPLN

Genetic Association Database (GAD)
PAPLN
Human Genome Epidemiology (HuGE) Navigator
PAPLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAPLN

No disorders were found for PAPLN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAPLN Gene

Publications for PAPLN Gene

  1. Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. (PMID: 19724244) Laje G. … McMahon F.J. (Pharmacogenet. Genomics 2009) 3 22 46 64
  2. Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. (PMID: 11076767) Kramerova I.A. … Fessler J.H. (Development 2000) 2 3 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. (PMID: 19734141) Apte S.S. (J. Biol. Chem. 2009) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PAPLN Gene

Sources for PAPLN Gene

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