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Aliases for PAPLN Gene

Aliases for PAPLN Gene

  • Papilin, Proteoglycan-Like Sulfated Glycoprotein 2 3 5

External Ids for PAPLN Gene

Previous GeneCards Identifiers for PAPLN Gene

  • GC14P071694
  • GC14P071696
  • GC14P072774
  • GC14P073704
  • GC14P053869

Summaries for PAPLN Gene

GeneCards Summary for PAPLN Gene

PAPLN (Papilin, Proteoglycan-Like Sulfated Glycoprotein) is a Protein Coding gene. GO annotations related to this gene include peptidase activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is ADAMTSL1.

Gene Wiki entry for PAPLN Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPLN Gene

Genomics for PAPLN Gene

Regulatory Elements for PAPLN Gene

Genomic Location for PAPLN Gene

Chromosome:
14
Start:
73,235,843 bp from pter
End:
73,274,640 bp from pter
Size:
38,798 bases
Orientation:
Plus strand

Genomic View for PAPLN Gene

Genes around PAPLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAPLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAPLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPLN Gene

Proteins for PAPLN Gene

  • Protein details for PAPLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95428-PPN_HUMAN
    Recommended name:
    Papilin
    Protein Accession:
    O95428
    Secondary Accessions:
    • B4DES8
    • B4DGE6
    • Q659F2
    • Q6UXJ4
    • Q6ZNM1
    • Q6ZUJ0
    • Q7Z681
    • Q8IVU0

    Protein attributes for PAPLN Gene

    Size:
    1278 amino acids
    Molecular mass:
    137700 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC97963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC86235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG57189.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57189.1; Type=Erroneous termination; Positions=1216; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAG57757.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH56406.1; Type=Miscellaneous discrepancy; Note=Partially unspliced mRNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for PAPLN Gene

neXtProt entry for PAPLN Gene

Proteomics data for PAPLN Gene at MOPED

Post-translational modifications for PAPLN Gene

  • Glycosylation at Ser 701, Thr 702, Thr 706, Thr 872, Ser 897, Ser 1221, and Thr 1225
  • Modification sites at PhosphoSitePlus

Other Protein References for PAPLN Gene

No data available for DME Specific Peptides for PAPLN Gene

Domains & Families for PAPLN Gene

Gene Families for PAPLN Gene

Suggested Antigen Peptide Sequences for PAPLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95428

UniProtKB/Swiss-Prot:

PPN_HUMAN :
  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Belongs to the papilin family.
Domain:
  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 PLAC domain.
  • Contains 5 TSP type-1 domains.
Family:
  • Belongs to the papilin family.
genes like me logo Genes that share domains with PAPLN: view

Function for PAPLN Gene

Gene Ontology (GO) - Molecular Function for PAPLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with PAPLN: view
genes like me logo Genes that share phenotypes with PAPLN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PAPLN

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAPLN Gene

Localization for PAPLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAPLN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAPLN Gene COMPARTMENTS Subcellular localization image for PAPLN gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PAPLN Gene

Pathways & Interactions for PAPLN Gene

SuperPathways for PAPLN Gene

No Data Available

Interacting Proteins for PAPLN Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345395%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000368190%0d%0a9606.ENSP00000201031%0d%0a9606.ENSP00000346964%0d%0a9606.ENSP00000363827%0d%0a
Selected Interacting proteins: O95428-PPN_HUMAN ENSP00000345395 for PAPLN Gene via I2D STRING

Gene Ontology (GO) - Biological Process for PAPLN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAPLN Gene

Drugs & Compounds for PAPLN Gene

(1) Drugs for PAPLN Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 494
genes like me logo Genes that share compounds with PAPLN: view

Transcripts for PAPLN Gene

Unigene Clusters for PAPLN Gene

Papilin, proteoglycan-like sulfated glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAPLN Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6: - - -
SP7:
SP8:

Relevant External Links for PAPLN Gene

GeneLoc Exon Structure for
PAPLN
ECgene alternative splicing isoforms for
PAPLN

Expression for PAPLN Gene

mRNA expression in normal human tissues for PAPLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAPLN Gene

This gene is overexpressed in Nerve - Tibial (x4.7).

Protein differential expression in normal tissues from HIPED for PAPLN Gene

This gene is overexpressed in Skin (20.8), Serum (14.9), and Amniocyte (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAPLN Gene



SOURCE GeneReport for Unigene cluster for PAPLN Gene Hs.509909

genes like me logo Genes that share expression patterns with PAPLN: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PAPLN Gene

Orthologs for PAPLN Gene

This gene was present in the common ancestor of animals.

Orthologs for PAPLN Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PAPLN 35
  • 81.92 (n)
  • 77.92 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Papln 35
  • 79.02 (n)
  • 75.24 (a)
Papln 16
Papln 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAPLN 35
  • 96.4 (n)
  • 95.61 (a)
PAPLN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Papln 35
  • 78.71 (n)
  • 74.61 (a)
cow
(Bos Taurus)
Mammalia PAPLN 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAPLN 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PAPLN 35
  • 60.27 (n)
  • 53.77 (a)
PAPLN 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAPLN 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia papln 35
  • 56.28 (n)
  • 51.76 (a)
zebrafish
(Danio rerio)
Actinopterygii papln 35
  • 54.68 (n)
  • 48.34 (a)
paplna 36
  • 42 (a)
OneToMany
paplnb 36
  • 41 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001662 35
  • 49.76 (n)
  • 38.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ppn 35
  • 47.42 (n)
  • 37.7 (a)
Ppn 36
  • 13 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mig-6 36
  • 16 (a)
OneToOne
Species with no ortholog for PAPLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAPLN Gene

ENSEMBL:
Gene Tree for PAPLN (if available)
TreeFam:
Gene Tree for PAPLN (if available)

Paralogs for PAPLN Gene

genes like me logo Genes that share paralogs with PAPLN: view

Variants for PAPLN Gene

Sequence variations from dbSNP and Humsavar for PAPLN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_039815 -
rs741842 - 73,251,012(+) TTGAC(A/G)CTAAT nc-transcript-variant, reference, missense
rs17126331 - 73,252,747(+) CCTGC(A/C)ATCTT nc-transcript-variant, reference, missense
rs17126352 - 73,254,537(+) TTGGC(A/G)TCCGG nc-transcript-variant, reference, missense
rs17126354 - 73,254,592(+) TACCG(C/T)AGCGT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PAPLN Gene

Variant ID Type Subtype PubMed ID
nsv902081 CNV Gain 21882294
dgv1957n71 CNV Loss 21882294
nsv902085 CNV Gain 21882294
nsv516851 CNV Loss 19592680
nsv85914 CNV Loss 16902084
nsv85407 CNV Loss 16902084
esv33062 CNV Gain 17666407

Variation tolerance for PAPLN Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.80; 96.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAPLN Gene

HapMap Linkage Disequilibrium report
PAPLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPLN Gene

Disorders for PAPLN Gene

Relevant External Links for PAPLN

Genetic Association Database (GAD)
PAPLN
Human Genome Epidemiology (HuGE) Navigator
PAPLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAPLN

No disorders were found for PAPLN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAPLN Gene

Publications for PAPLN Gene

  1. Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. (PMID: 11076767) Kramerova I.A. … Fessler J.H. (Development 2000) 2 3 23 67
  2. Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. (PMID: 19724244) Laje G. … McMahon F.J. (Pharmacogenet. Genomics 2009) 3 23
  3. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. (PMID: 19734141) Apte S.S. (J. Biol. Chem. 2009) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV. (PMID: 19297413) Kawano T. … Culotti J.G. (Development 2009) 23

Products for PAPLN Gene

Sources for PAPLN Gene

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