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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PAPLN Gene

protein-coding GIFtS: 50
GCID: GC14P073704

papilin, proteoglycan-like sulfated glycoprotein

Explore 2 diseases affiliated with
PAPLN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Papilin, Proteoglycan-Like Sulfated Glycoprotein¹ ²
MGC50452¹
Papilin¹

External Ids:	HGNC: 19262¹	Entrez Gene: 89932²	Ensembl: ENSG00000100767⁷	UniProtKB: O95428³

Export aliases for PAPLN gene to outside databases

Previous GC identifers: GC14P071694 GC14P071696 GC14P072774 GC14P053869

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for PAPLN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PAPLN gene promoter:
GATA-3 STAT5A C/EBPalpha CHOP-10 AREB6 PPAR-gamma1 HOXA5 c-Myb ZID PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PAPLN promoter sequence

Search SABiosciences Chromatin IP Primers for PAPLN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAPLN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.2

PAPLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAPLN gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P073704: view genomic region (about GC identifiers)

Start:	73,704,205 bp from pter	End:	73,741,348 bp from pter
Size:	37,144 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPN_HUMAN, O95428 (See protein sequence)

Recommended Name: Papilin precursor

Size: 1278 amino acids; 137700 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=AAC97963.1; Type=Erroneous gene model prediction; Sequence=BAC86235.1; Type=Erroneous

initiation; Note=Translation N-terminally extended; Sequence=BAG57189.1; Type=Erroneous initiation; Note=Translation

N-terminally shortened; Sequence=BAG57189.1; Type=Erroneous termination; Positions=1216; Note=Translated as Glu;

Sequence=BAG57757.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH56406.1;

Type=Miscellaneous discrepancy; Note=Partially unspliced mRNA;

Secondary accessions: B4DES8 B4DGE6 Q659F2 Q6UXJ4 Q6ZNM1 Q6ZUJ0 Q7Z681 Q8IVU0

Alternative splicing: 6 isoforms: O95428-1 O95428-2 O95428-5 O95428-6 O95428-3 O95428-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PAPLN: NX_O95428

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95428

PAPLN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775733.3

ENSEMBL proteins:

ENSP00000345395 ENSP00000452455 ENSP00000216658 ENSP00000451803 ENSP00000451729

ENSP00000451053 ENSP00000453664 ENSP00000403403 ENSP00000370558

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PAPLN

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	--	--
GO:0005604	basement membrane	IEA	--

PAPLN for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PAPLN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PAPLN for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR003598 Ig_sub2

IPR000884 Thrombospondin_1_rpt

IPR010909 PLAC

IPR013098 Ig_I-set

IPR002223 Prot_inh_Kunz-m

Graphical View of Domain Structure for InterPro Entry O95428

ProtoNet protein and cluster: O95428

3 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB008085 Thrombospondin type 1 repeat signature

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: PPN_HUMAN, O95428

Similarity: Belongs to the papilin family

Similarity: Contains 1 BPTI/Kunitz inhibitor domain

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 PLAC domain

Similarity: Contains 5 TSP type-1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: PAPLN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAPLN
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PAPLN (see all 9):
		hsa-miR-548p hsa-miR-3194-5p hsa-miR-205 hsa-miR-324-3p hsa-miR-3158-3p hsa-miR-890 hsa-miR-155 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: PAPLN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAPLN (see all 6) OriGene shRNA RFP: PAPLN OriGene siRNA: PAPLN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAPLN

Gene Editing
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DNA2.0 Custom Protein Engineering Service for PAPLN

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAPLN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAPLN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PAPLN (NM_173462)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAPLN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PAPLN
		Search LifeMap BioReagents cell lines for PAPLN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPLN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

PAPLN for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PAPLN:

Decreased viability with pacli

Animal Models:
Mouse knock-out Papln^tm1Lex for PAPLN
1 MGI phenotypic allele

for Papln (no phenotypes)

PAPLN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PAPLN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/14 Interacting proteins for PAPLN (O95428³ ENSP00000345395⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKIRIN1	Q9H9L7³	I2D: score=5
BICC1	Q9H694³	I2D: score=5
CYB5D2	Q8WUJ1³	I2D: score=5
NUP54	Q7Z3B4³	I2D: score=5
PYGM	P11217³	I2D: score=5

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PAPLN
Search CenterWatch for drugs/clinical trials and news about PAPLN / PPN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PAPLN gene:

NM_173462.3

Unigene Cluster for PAPLN:

Papilin, proteoglycan-like sulfated glycoprotein

Hs.509909 [show with all ESTs]

Unigene Representative Sequence: NM_173462

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340738(uc001xnw.4 uc010ttw.2 uc010arm.3 uc010arn.3)

ENST00000555123 ENST00000216658 ENST00000554301 ENST00000555445 ENST00000555035

ENST00000557061 ENST00000554314 ENST00000555700 ENST00000559759 ENST00000554527

ENST00000427855(uc010arl.3 uc010ttx.2 uc010tty.2) ENST00000381166

miRNA Products:		OriGene 3'-UTR Clone: PAPLN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAPLN
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PAPLN (see all 9):
		hsa-miR-548p hsa-miR-3194-5p hsa-miR-205 hsa-miR-324-3p hsa-miR-3158-3p hsa-miR-890 hsa-miR-155 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: PAPLN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAPLN (see all 6) OriGene shRNA RFP: PAPLN OriGene siRNA: PAPLN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAPLN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAPLN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAPLN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PAPLN (NM_173462)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAPLN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAPLN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAPLN Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAPLN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAPLN

Additional cDNA sequence:

AK021713.1 AK125658.1 AK126555.1 AK127354.1 AK131073.1 AK293773.1 AK294560.1 AY358330.1

BC042057.1 BC136623.1 BC144315.1 BX537757.1

11 DOTS entries:

DT.100717869 DT.91901237 DT.100749627 DT.111315 DT.101974201 DT.100749628 DT.100683216 DT.40127819

DT.92014360 DT.92028546 DT.95142491

24/89 AceView cDNA sequences (see all 89):

AW236801 AA135886 AI918676 AL110280 BQ023790 CA390119 AI651904 CA397924

AI862632 AK125658 AI656780 AA385094 BF115161 BQ016936 AI199317 NM_173462

AA456549 BF594725 BU685194 AK127354 N49018 AI830537 AI628614 BF592901

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PAPLN (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16a	·	16b	·	16c	^	17
SP1:			-
SP2:
SP3:
SP4:																																													-
SP5:

ECgene alternative splicing isoforms for PAPLN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PAPLN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCACTTATG

About this image

PAPLN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PAPLN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAPLN

SOURCE GeneReport for Unigene cluster: Hs.509909

SABiosciences Custom PCR Arrays for PAPLN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAPLN Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAPLN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPLN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PAPLN gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PAPLN¹	papilin, proteoglycan-like sulfated glycoprotein	61.56(n) 56.05(a)		428873 XM_426430.3 XP_426430.3
lizard (Anolis carolinensis)	Reptilia	PAPLN⁶	--	52(a)	1 ↔ 1	1(39024493-39071630)
zebrafish (Danio rerio)	Actinopterygii	papln¹	papilin, proteoglycan-like sulfated glycoprotein	54.87(n) 48.38(a)		562930 XM_001919000.3 XP_001919035.3
fruit fly (Drosophila melanogaster)	Insecta	Ppn¹	Papilin	47.04(n) 37.24(a)		43872 NM_001170290.1 NP_001163761.1
worm (Caenorhabditis elegans)	Secernentea	mig-17⁶	ADAM family mig-17	4(a)	possible ortholog	V(11446634-11449228)

ENSEMBL Gene Tree for PAPLN (if available)
TreeFam Gene Tree for PAPLN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PAPLN gene

ADAMTSL4² ADAMTS13² ADAMTSL1² ENSG00000215616² THSD4² ADAMTSL2² ADAMTSL3² ADAMTSL5²

10 SIMAP similar genes for PAPLN using alignment to 6 protein entries: PPN_HUMAN (see all proteins):

COL28A1 ADAMTS16 ITIL ADAMTSL5 ADAMTS13 SPINT3

TFPI2 ADAMTSL1 IGDCC3 TFPI

PAPLN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140266051^1,2	C	other	73718386(+)	`ATGTTC/TGTGGG`	2	R C	mis¹		1		NA	4506
rs3025795^1,2	H	--	73702211(+)	`GTCCTC/TTTTGC`	1	--	us2k¹		4		NS EA	420
rs77667281^1,2		--	73702323(+)	`GCTTCC/TCCCAC`	1	--	us2k¹		2		CSA WA	120
rs148805054^1,2		--	73702446(+)	`TTTTCC/TTCTTT`	1	--	us2k¹		0	--	--	--	--
rs362411^1,2	C,F,H,	--	73702501(+)	`TCTTTG/ACTTAA`	1	--	us2k¹		6		MN NS EA WA	720
rs17126147^1,2	C,F,H,	--	73702613(+)	`ATGTTC/TTAATA`	1	--	us2k¹		8		NA NS EA WA	678
rs193120064^1,2		--	73702717(+)	`AGGGAA/GAAGTG`	1	--	us2k¹		0	--	--	--	--
rs142397203^1,2		--	73702787(+)	`ACCACC/GCCACC`	1	--	us2k¹		0	--	--	--	--
rs74061009^1,2	C,	--	73702798(+)	`CCCAAC/ACTCTC`	1	--	us2k¹		1		WA	2
rs78387414^1,2	F,	--	73702858(+)	`GATGAG/CTGAAT`	1	--	us2k¹		3		WA NA EA	358

HapMap Linkage Disequilibrium report for PAPLN (73704205 - 73741348 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PAPLN
2 CNVs: 49408 49409
1 Indel: 11088

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAPLN

DNA2.0 Custom Variant and Variant Library Synthesis for PAPLN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PAPLN for disorders About GeneDecksing

2 diseases for PAPLN: About MalaCards

weill-marchesani syndrome brachydactyly

1 disease from the University of Copenhagen DISEASES database for PAPLN:

Weill-Marchesani syndrome

Human Genome Epidemiology (HuGE) Navigator: PAPLN (2 documents)

Export disorders for PAPLN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PAPLN gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with PAPLN)

Utopia: connect your pdf to the dynamic
world of online information

Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. (PubMed id 11076767)^{1, 3, 9} Kramerova I.A....Fessler J.H. (2000)
A disintegrin-like and metalloprotease (reprolysin-ty pe) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechan isms. (PubMed id 19734141)^{1, 3} Apte S.S. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Genome-wide association study of suicidal ideation em erging during citalopram treatment of depressed outpatients. (PubMed id 19724244)^{1, 9} Laje G....McMahon F.J. (2009)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89932	HGNC: 19262	AceView: PAPLN	Ensembl:ENSG00000100767	euGenes: HUgn89932
ECgene: PAPLN	H-InvDB: PAPLN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PAPLN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PAPLN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PAPLN gene:
Search GeneIP for patents involving PAPLN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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PAPLN Gene

papilin, proteoglycan-like sulfated glycoprotein

Aliases
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Proteins
for PAPLN gene

Protein Domains /
Families
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Function
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Expression
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Orthologs
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Disorders / Diseases
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External Searches for PAPLN gene

Genome Databases showing PAPLN gene

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PAPLN Gene

papilin, proteoglycan-like sulfated glycoprotein

Aliasesfor PAPLN gene

Summariesfor PAPLN gene

Genomic Viewsfor PAPLN gene

Proteinsfor PAPLN gene

Protein Domains /Familiesfor PAPLN gene

Functionfor PAPLN gene

Pathways & Interactionsfor PAPLN gene

Drugs & Compoundsfor PAPLN gene

Transcriptsfor PAPLN gene

Expression for PAPLN gene

Orthologsfor PAPLN gene

Paralogsfor PAPLN gene

Genomic Variantsfor PAPLN gene

Disorders / Diseasesfor PAPLN gene

Publicationsfor PAPLN gene

External Searches for PAPLN gene

Genome Databases showing PAPLN gene

Other Databases showing PAPLN gene

Specialized Databases showing PAPLN gene

Intellectual Propertyfor PAPLN gene

Productsfor PAPLN gene

View Random Gene

Aliases
for PAPLN gene

Summaries
for PAPLN gene

Genomic Views
for PAPLN gene

Proteins
for PAPLN gene

Protein Domains /
Families
for PAPLN gene

Function
for PAPLN gene

Pathways & Interactions
for PAPLN gene

Drugs & Compounds
for PAPLN gene

Transcripts
for PAPLN gene

Expression
for PAPLN gene

Orthologs
for PAPLN gene

Paralogs
for PAPLN gene

Genomic Variants
for PAPLN gene

Disorders / Diseases
for PAPLN gene

Publications
for PAPLN gene

Intellectual Property
for PAPLN gene

Products
for PAPLN gene