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Aliases for PAPD7 Gene

Aliases for PAPD7 Gene

  • PAP Associated Domain Containing 7 2 3 5
  • Topoisomerase-Related Function Protein 4-1 2 3 4
  • TRAMP-Like Complex Polyadenylate Polymerase 3 4
  • PAP-Associated Domain-Containing Protein 7 3 4
  • Polymerase (DNA-Directed) Sigma 2 3
  • Polymerase (DNA Directed) Sigma 2 3
  • Terminal Uridylyltransferase 5 3 4
  • DNA Polymerase Kappa 2 3
  • DNA Polymerase Sigma 3 4
  • TUTase 5 3 4
  • TRF4-1 3 4
  • LAK-1 3 4
  • POLS 3 4
  • TRF4 3 4
  • EC 2.7.7.19 4
  • TUTase5 2
  • TUTASE5 3
  • TRF41 3
  • LAK1 3
  • POLK 3

External Ids for PAPD7 Gene

Previous HGNC Symbols for PAPD7 Gene

  • POLS

Summaries for PAPD7 Gene

Entrez Gene Summary for PAPD7 Gene

  • The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for PAPD7 Gene

PAPD7 (PAP Associated Domain Containing 7) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Cell Cycle Control of Chromosomal Replication. GO annotations related to this gene include DNA-directed DNA polymerase activity and polynucleotide adenylyltransferase activity. An important paralog of this gene is PAPD5.

UniProtKB/Swiss-Prot for PAPD7 Gene

  • Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAPD7 Gene

Genomics for PAPD7 Gene

Regulatory Elements for PAPD7 Gene

Enhancers for PAPD7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAPD7 on UCSC Golden Path with GeneCards custom track

Promoters for PAPD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAPD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAPD7 Gene

Chromosome:
5
Start:
6,713,007 bp from pter
End:
6,757,048 bp from pter
Size:
44,042 bases
Orientation:
Plus strand

Genomic View for PAPD7 Gene

Genes around PAPD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAPD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAPD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAPD7 Gene

Proteins for PAPD7 Gene

  • Protein details for PAPD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XG87-PAPD7_HUMAN
    Recommended name:
    Non-canonical poly(A) RNA polymerase PAPD7
    Protein Accession:
    Q5XG87
    Secondary Accessions:
    • A8K1E2
    • M1JCE6
    • O43289
    • Q17RZ1
    • Q9Y6C1

    Protein attributes for PAPD7 Gene

    Size:
    772 amino acids
    Molecular mass:
    82360 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
    SequenceCaution:
    • Sequence=AAD45198.1; Type=Frameshift; Positions=474; Evidence={ECO:0000305};

    Alternative splice isoforms for PAPD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAPD7 Gene

Proteomics data for PAPD7 Gene at MOPED

Post-translational modifications for PAPD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAPD7 Gene

No data available for DME Specific Peptides for PAPD7 Gene

Domains & Families for PAPD7 Gene

Protein Domains for PAPD7 Gene

Suggested Antigen Peptide Sequences for PAPD7 Gene

Graphical View of Domain Structure for InterPro Entry

Q5XG87

UniProtKB/Swiss-Prot:

PAPD7_HUMAN :
  • Contains 1 PAP-associated domain.
  • Belongs to the DNA polymerase type-B-like family.
Domain:
  • Contains 1 PAP-associated domain.
Family:
  • Belongs to the DNA polymerase type-B-like family.
genes like me logo Genes that share domains with PAPD7: view

No data available for Gene Families for PAPD7 Gene

Function for PAPD7 Gene

Molecular function for PAPD7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.

Enzyme Numbers (IUBMB) for PAPD7 Gene

Gene Ontology (GO) - Molecular Function for PAPD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0004652 polynucleotide adenylyltransferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with PAPD7: view
genes like me logo Genes that share phenotypes with PAPD7: view

Animal Model Products

CRISPR Products

miRNA for PAPD7 Gene

miRTarBase miRNAs that target PAPD7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAPD7 Gene

Localization for PAPD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAPD7 Gene

Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAPD7 Gene COMPARTMENTS Subcellular localization image for PAPD7 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PAPD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PAPD7: view

Pathways & Interactions for PAPD7 Gene

genes like me logo Genes that share pathways with PAPD7: view

Pathways by source for PAPD7 Gene

1 KEGG pathway for PAPD7 Gene

Gene Ontology (GO) - Biological Process for PAPD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair NAS 10066793
GO:0042493 response to drug IDA 10066793
GO:0051301 cell division IEA --
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with PAPD7: view

No data available for SIGNOR curated interactions for PAPD7 Gene

Drugs & Compounds for PAPD7 Gene

(2) Drugs for PAPD7 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1898
Diphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PAPD7: view

Transcripts for PAPD7 Gene

Unigene Clusters for PAPD7 Gene

PAP associated domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAPD7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for PAPD7 Gene

GeneLoc Exon Structure for
PAPD7
ECgene alternative splicing isoforms for
PAPD7

Expression for PAPD7 Gene

mRNA expression in normal human tissues for PAPD7 Gene

Protein differential expression in normal tissues from HIPED for PAPD7 Gene

This gene is overexpressed in Serum (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAPD7 Gene



SOURCE GeneReport for Unigene cluster for PAPD7 Gene Hs.481542

genes like me logo Genes that share expression patterns with PAPD7: view

Protein tissue co-expression partners for PAPD7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PAPD7 Gene

Orthologs for PAPD7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAPD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAPD7 35
  • 85.03 (n)
  • 90.74 (a)
PAPD7 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAPD7 35
  • 88.5 (n)
  • 93.36 (a)
PAPD7 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Papd7 35
  • 86.72 (n)
  • 94.83 (a)
Papd7 16
Papd7 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Papd7 35
  • 86.69 (n)
  • 94.45 (a)
oppossum
(Monodelphis domestica)
Mammalia PAPD7 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAPD7 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAPD7 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAPD7 35
  • 78.04 (n)
  • 85.05 (a)
PAPD7 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAPD7 36
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii papd7 35
  • 65.82 (n)
  • 68.23 (a)
papd7 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Trf4-1 36
  • 23 (a)
ManyToMany
Trf4-2 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gld-4 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAP2 36
  • 20 (a)
ManyToMany
TRF5 36
  • 18 (a)
ManyToMany
TRF5 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9243 36
  • 29 (a)
OneToMany
Species with no ortholog for PAPD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PAPD7 Gene

ENSEMBL:
Gene Tree for PAPD7 (if available)
TreeFam:
Gene Tree for PAPD7 (if available)

Paralogs for PAPD7 Gene

Paralogs for PAPD7 Gene

(2) SIMAP similar genes for PAPD7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PAPD7: view

Variants for PAPD7 Gene

Sequence variations from dbSNP and Humsavar for PAPD7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs28381415 - 6,750,370(+) ATGCA(A/G)TGGGG reference, missense
rs28381418 - 6,751,114(+) TGGCC(A/G)GCTTA reference, missense
rs877238 -- 6,729,582(+) CCCTG(C/T)GGTAG intron-variant
rs877239 -- 6,729,599(+) GTTGT(G/T)CTGTG intron-variant
rs880993 -- 6,732,007(-) CTAAA(C/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAPD7 Gene

Variant ID Type Subtype PubMed ID
nsv461922 CNV Loss 19166990
nsv822993 CNV Loss 20364138
nsv822994 CNV Gain 20364138
nsv822995 CNV Gain 20364138
nsv822996 CNV Gain 20364138
esv23095 CNV Gain+Loss 19812545
nsv830196 CNV Gain 17160897

Variation tolerance for PAPD7 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAPD7 Gene

HapMap Linkage Disequilibrium report
PAPD7
Human Gene Mutation Database (HGMD)
PAPD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAPD7 Gene

Disorders for PAPD7 Gene

Relevant External Links for PAPD7

Genetic Association Database (GAD)
PAPD7
Human Genome Epidemiology (HuGE) Navigator
PAPD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAPD7

No disorders were found for PAPD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAPD7 Gene

Publications for PAPD7 Gene

  1. The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. (PMID: 10066793) Walowsky C. … Christman M.F. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Pol kappa: a DNA polymerase required for sister chromatid cohesion. (PMID: 10926539) Wang Z. … Christman M.F. (Science 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy. (PMID: 23776197) Leandro-GarcA-a L.J. … RodrA-guez-Antona C. (J. Med. Genet. 2013) 3
  5. Molecular cloning and characterization of a novel isoform of the non- canonical poly(A) polymerase PAPD7. (PMID: 23376078) Ogami K. … Hoshino S.I. (Biochem. Biophys. Res. Commun. 2013) 3

Products for PAPD7 Gene

Sources for PAPD7 Gene

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